{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T17:12:13Z","timestamp":1784049133643,"version":"3.55.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Digestive Medical Coordinated Development Center of Beijing Municipal Administration of Hospitals","award":["no. XXX0101, XXZ0501, XXT03"],"award-info":[{"award-number":["no. XXX0101, XXZ0501, XXT03"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 81800451"],"award-info":[{"award-number":["No. 81800451"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s10495-026-02379-y","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T17:51:15Z","timestamp":1781805075000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["USP9X regulates copper-induced CASP9\/CASP3\/GSDME-dependent pyroptosis by deubiquitinating JAK1"],"prefix":"10.1007","volume":"31","author":[{"given":"Huaduan","family":"Zi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengcheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"issue":"8","key":"2379_CR1","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1080\/15548627.2023.2200554","volume":"19","author":"Q Xue","year":"2023","unstructured":"Xue Q, Kang R, Klionsky DJ, Tang D, Liu J, Chen X (2023) Copper metabolism in cell death and autophagy. Autophagy 19(8):2175. https:\/\/doi.org\/10.1080\/15548627.2023.2200554","journal-title":"Autophagy"},{"issue":"6586","key":"2379_CR2","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1126\/science.abf0529","volume":"375","author":"P Tsvetkov","year":"2022","unstructured":"Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, Eaton JK, Frenkel E, Kocak M, Corsello SM, Lutsenko S, Kanarek N, Santagata S, Golub TR (2022) Copper induces cell death by targeting lipoylated TCA cycle proteins. Science 375(6586):1254. https:\/\/doi.org\/10.1126\/science.abf0529","journal-title":"Science"},{"key":"2379_CR3","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1146\/annurev-immunol-042617-053010","volume":"36","author":"S Nagata","year":"2018","unstructured":"Nagata S (2018) Apoptosis and clearance of apoptotic cells. Annu Rev Immunol 36:489. https:\/\/doi.org\/10.1146\/annurev-immunol-042617-053010","journal-title":"Annu Rev Immunol"},{"issue":"5","key":"2379_CR4","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","volume":"18","author":"X Chen","year":"2021","unstructured":"Chen X, Kang R, Kroemer G, Tang D (2021) Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol 18(5):280. https:\/\/doi.org\/10.1038\/s41571-020-00462-0","journal-title":"Nat Rev Clin Oncol"},{"key":"2379_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102122","volume":"46","author":"X Ren","year":"2021","unstructured":"Ren X, Li Y, Zhou Y, Hu W, Yang C, Jing Q, Zhou C, Wang X, Hu J, Wang L, Yang J, Wang H, Xu H, Li H, Tong X, Wang Y, Du J (2021) Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram\/copper-induced ferroptosis. Redox Biol 46:102122. https:\/\/doi.org\/10.1016\/j.redox.2021.102122","journal-title":"Redox Biol"},{"issue":"12","key":"2379_CR6","doi-asserted-by":"publisher","first-page":"3527","DOI":"10.1002\/1878-0261.13079","volume":"15","author":"W Gao","year":"2021","unstructured":"Gao W, Huang Z, Duan J, Nice EC, Lin J, Huang C (2021) Elesclomol induces copper-dependent ferroptosis in colorectal cancer cells via degradation of ATP7A. Mol Oncol 15(12):3527. https:\/\/doi.org\/10.1002\/1878-0261.13079","journal-title":"Mol Oncol"},{"issue":"7661","key":"2379_CR7","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature22393","volume":"547","author":"Y Wang","year":"2017","unstructured":"Wang Y, Gao W, Shi X, Ding J, Liu W, He H, Wang K, Shao F (2017) Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature 547(7661):99. https:\/\/doi.org\/10.1038\/nature22393","journal-title":"Nature"},{"issue":"1","key":"2379_CR8","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jhep.2020.07.041","volume":"74","author":"S Gaul","year":"2021","unstructured":"Gaul S, Leszczynska A, Alegre F, Kaufmann B, Johnson CD, Adams LA, Wree A, Damm G, Seehofer D, Calvente CJ, Povero D, Kisseleva T, Eguchi A, McGeough MD, Hoffman HM, Pelegrin P, Laufs U, Feldstein AE (2021) Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis. J Hepatol 74(1):156. https:\/\/doi.org\/10.1016\/j.jhep.2020.07.041","journal-title":"J Hepatol"},{"key":"2379_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25084537","author":"K Sayaf","year":"2024","unstructured":"Sayaf K, Battistella S, Russo FP (2024) NLRP3 inflammasome in acute and chronic liver diseases. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms25084537","journal-title":"Int J Mol Sci"},{"issue":"7","key":"2379_CR10","doi-asserted-by":"publisher","first-page":"2721","DOI":"10.1172\/jci85226","volume":"126","author":"J Lichtmannegger","year":"2016","unstructured":"Lichtmannegger J, Leitzinger C, Wimmer R, Schmitt S, Schulz S, Kabiri Y, Eberhagen C, Rieder T, Janik D, Neff F, Straub BK, Schirmacher P, DiSpirito AA, Bandow N, Baral BS, Flatley A, Kremmer E, Denk G, Reiter FP, Hohenester S, Eckardt-Schupp F, Dencher NA, Adamski J, Sauer V, Niemietz C, Schmidt HHJ, Merle U, Gotthardt DN, Kroemer G, Weiss KH, Zischka H (2016) Methanobactin reverses acute liver failure in a rat model of Wilson disease. J Clin Investig 126(7):2721. https:\/\/doi.org\/10.1172\/jci85226","journal-title":"J Clin Investig"},{"issue":"10","key":"2379_CR11","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1136\/jnnp-2021-326123","volume":"92","author":"S Shribman","year":"2021","unstructured":"Shribman S, Poujois A, Bandmann O, Czlonkowska A, Warner TT (2021) Wilson\u2019s disease: update on pathogenesis, biomarkers and treatments. J Neurol Neurosurg Psychiatry 92(10):1053. https:\/\/doi.org\/10.1136\/jnnp-2021-326123","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"2379_CR12","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.cellsig.2006.09.003","volume":"19","author":"HS Kim","year":"2007","unstructured":"Kim HS, Lee MS (2007) STAT1 as a key modulator of cell death. Cell Signal 19(3):454. https:\/\/doi.org\/10.1016\/j.cellsig.2006.09.003","journal-title":"Cell Signal"},{"issue":"2","key":"2379_CR13","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.jhep.2012.01.029","volume":"57","author":"B Gao","year":"2012","unstructured":"Gao B, Wang H, Lafdil F, Feng D (2012) STAT proteins - key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver. J Hepatol 57(2):430. https:\/\/doi.org\/10.1016\/j.jhep.2012.01.029","journal-title":"J Hepatol"},{"issue":"10","key":"2379_CR14","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1172\/jci15841","volume":"110","author":"F Hong","year":"2002","unstructured":"Hong F, Jaruga B, Kim WH, Radaeva S, El-Assal ON, Tian Z, Nguyen VA, Gao B (2002) Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS. J Clin Invest 110(10):1503. https:\/\/doi.org\/10.1172\/jci15841","journal-title":"J Clin Invest"},{"issue":"1","key":"2379_CR15","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12967-022-03366-y","volume":"20","author":"Z Song","year":"2022","unstructured":"Song Z, Liu X, Zhang W, Luo Y, Xiao H, Liu Y, Dai G, Hong J, Li A (2022) Ruxolitinib suppresses liver fibrosis progression and accelerates fibrosis reversal via selectively targeting Janus kinase 1\/2. J Transl Med 20(1):157. https:\/\/doi.org\/10.1186\/s12967-022-03366-y","journal-title":"J Transl Med"},{"issue":"1","key":"2379_CR16","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/nri3581","volume":"14","author":"LB Ivashkiv","year":"2014","unstructured":"Ivashkiv LB, Donlin LT (2014) Regulation of type I interferon responses. Nat Rev Immunol 14(1):36. https:\/\/doi.org\/10.1038\/nri3581","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"2379_CR17","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.cell.2020.11.025","volume":"184","author":"R Karki","year":"2021","unstructured":"Karki R, Sharma BR, Tuladhar S, Williams EP, Zalduondo L, Samir P, Zheng M, Sundaram B, Banoth B, Malireddi RKS, Schreiner P, Neale G, Vogel P, Webby R, Jonsson CB, Kanneganti TD (2021) Synergism of TNF-alpha and IFN-gamma triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes. Cell 184(1):149. https:\/\/doi.org\/10.1016\/j.cell.2020.11.025","journal-title":"Cell"},{"issue":"2","key":"2379_CR18","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1002\/hep.26047","volume":"57","author":"V Medici","year":"2013","unstructured":"Medici V, Shibata NM, Kharbanda KK, LaSalle JM, Woods R, Liu S, Engelberg JA, Devaraj S, T\u00f6r\u00f6k NJ, Jiang JX, Havel PJ, L\u00f6nnerdal B, Kim K, Halsted CH (2013) Wilson\u2019s disease: changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease. Hepatology 57(2):555. https:\/\/doi.org\/10.1002\/hep.26047","journal-title":"Hepatology"},{"issue":"8","key":"2379_CR19","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/nrm2731","volume":"10","author":"D Komander","year":"2009","unstructured":"Komander D, Clague MJ, Urb\u00e9 S (2009) Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol 10(8):550. https:\/\/doi.org\/10.1038\/nrm2731","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"2379_CR20","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1007\/s10787-021-00890-z","volume":"29","author":"N Parihar","year":"2021","unstructured":"Parihar N, Bhatt LK (2021) Deubiquitylating enzymes: potential target in autoimmune diseases. Inflammopharmacology 29(6):1683. https:\/\/doi.org\/10.1007\/s10787-021-00890-z","journal-title":"Inflammopharmacology"},{"issue":"7","key":"2379_CR21","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1158\/0008-5472.Can-22-1812","volume":"83","author":"Y Ren","year":"2023","unstructured":"Ren Y, Feng M, Hao X, Liu X, Li J, Li P, Gao J, Qi Q, Du L, Wang C, Wang Q, Wang Y (2023) USP48 stabilizes gasdermin E to promote pyroptosis in cancer. Cancer Res 83(7):1074. https:\/\/doi.org\/10.1158\/0008-5472.Can-22-1812","journal-title":"Cancer Res"},{"issue":"9\u201310","key":"2379_CR22","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1007\/s10495-022-01755-8","volume":"27","author":"Y Chen","year":"2022","unstructured":"Chen Y, Ren W, Wang Q, He Y, Ma D, Cai Z (2022) The regulation of necroptosis by ubiquitylation. Apoptosis 27(9\u201310):668. https:\/\/doi.org\/10.1007\/s10495-022-01755-8","journal-title":"Apoptosis"},{"issue":"11","key":"2379_CR23","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206792","volume":"10","author":"Y Pan","year":"2023","unstructured":"Pan Y, Shu G, Fu L, Huang K, Zhou X, Gui C, Liu H, Jin X, Chen M, Li P, Cen J, Feng Z, Lu J, Chen Z, Li J, Xu Q, Wang Y, Liang H, Wang Z, Deng Q, Chen W, Luo J, Yang J, Zhang J, Wei J (2023) EHBP1L1 Drives immune evasion in renal cell carcinoma through binding and stabilizing JAK1. Adv Sci 10(11):e2206792. https:\/\/doi.org\/10.1002\/advs.202206792","journal-title":"Adv Sci"},{"issue":"6","key":"2379_CR24","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1016\/j.ymthe.2021.02.018","volume":"29","author":"M Li","year":"2021","unstructured":"Li M, Xu Y, Liang J, Lin H, Qi X, Li F, Han P, Gao Y, Yang X (2021) USP22 deficiency in melanoma mediates resistance to T cells through IFNgamma-JAK1-STAT1 signal axis. Mol Ther 29(6):2108. https:\/\/doi.org\/10.1016\/j.ymthe.2021.02.018","journal-title":"Mol Ther"},{"issue":"5","key":"2379_CR25","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1016\/j.jhep.2022.01.009","volume":"76","author":"M Yang","year":"2022","unstructured":"Yang M, Wu X, Hu J, Wang Y, Wang Y, Zhang L, Huang W, Wang X, Li N, Liao L, Chen M, Xiao N, Dai Y, Liang H, Huang W, Yuan L, Pan H, Li L, Chen L, Liu L, Liang L, Guan J (2022) COMMD10 inhibits HIF1alpha\/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma. J Hepatol 76(5):1138. https:\/\/doi.org\/10.1016\/j.jhep.2022.01.009","journal-title":"J Hepatol"},{"key":"2379_CR26","doi-asserted-by":"publisher","DOI":"10.1093\/mtomcs\/mfad010","author":"B Zhang","year":"2023","unstructured":"Zhang B, Burke R (2023) Copper homeostasis and the ubiquitin proteasome system. Metallomics. https:\/\/doi.org\/10.1093\/mtomcs\/mfad010","journal-title":"Metallomics"},{"issue":"8","key":"2379_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202206212","volume":"10","author":"L Lu","year":"2023","unstructured":"Lu L, Zi H, Zhou J, Huang J, Deng Z, Tang Z, Li L, Shi X, Lo PC, Lovell JF, Deng D, Wan C, Jin H (2023) Engineered microparticles for treatment of murine brain metastasis by reprograming tumor microenvironment and inhibiting MAPK pathway. Adv Sci 10(8):e2206212. https:\/\/doi.org\/10.1002\/advs.202206212","journal-title":"Adv Sci"},{"issue":"2","key":"2379_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2024.101418","volume":"19","author":"D Zhou","year":"2025","unstructured":"Zhou D, Zi H, Yang X, Li X, Li Y, Xu A, Zhang B, Zhang W, Ou X, Jia J, Huang J, You H (2025) Dysfunction of ATP7B splicing variant caused by enhanced interaction with COMMD1 in Wilson disease. Cell Mol Gastroenterol Hepatol 19(2):101418. https:\/\/doi.org\/10.1016\/j.jcmgh.2024.101418","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"30","key":"2379_CR29","doi-asserted-by":"publisher","first-page":"9394","DOI":"10.1073\/pnas.1511711112","volume":"112","author":"CK Wan","year":"2015","unstructured":"Wan CK, Andraski AB, Spolski R, Li P, Kazemian M, Oh J, Samsel L, Swanson PA 2nd, McGavern DB, Sampaio EP, Freeman AF, Milner JD, Holland SM, Leonard WJ (2015) Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells. Proc Natl Acad Sci U S A 112(30):9394. https:\/\/doi.org\/10.1073\/pnas.1511711112","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"24","key":"2379_CR30","doi-asserted-by":"publisher","first-page":"4231","DOI":"10.1021\/acschemneuro.0c00517","volume":"11","author":"C Gao","year":"2020","unstructured":"Gao C, Yan Y, Chen G, Wang T, Luo C, Zhang M, Chen X, Tao L (2020) Autophagy activation represses pyroptosis through the IL-13 and JAK1\/STAT1 pathways in a mouse model of moderate traumatic brain injury. ACS Chem Neurosci 11(24):4231. https:\/\/doi.org\/10.1021\/acschemneuro.0c00517","journal-title":"ACS Chem Neurosci"},{"issue":"6511","key":"2379_CR31","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1126\/science.abb9818","volume":"369","author":"F Humphries","year":"2020","unstructured":"Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA (2020) Succination inactivates gasdermin D and blocks pyroptosis. Science 369(6511):1633. https:\/\/doi.org\/10.1126\/science.abb9818","journal-title":"Science"},{"issue":"5","key":"2379_CR32","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1023\/a:1009616228304","volume":"5","author":"HU Simon","year":"2000","unstructured":"Simon HU, Haj-Yehia A, Levi-Schaffer F (2000) Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5(5):415. https:\/\/doi.org\/10.1023\/a:1009616228304","journal-title":"Apoptosis"},{"issue":"4-5","key":"2379_CR33","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.mam.2005.07.015","volume":"26","author":"JY Uriu-Adams","year":"2005","unstructured":"Uriu-Adams JY, Keen CL (2005) Copper, oxidative stress, and human health. Mol Aspects Med 26(4\u20135):268. https:\/\/doi.org\/10.1016\/j.mam.2005.07.015","journal-title":"Mol Aspects Med"},{"issue":"2","key":"2379_CR34","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/s41419-021-03458-5","volume":"12","author":"X Shen","year":"2021","unstructured":"Shen X, Wang H, Weng C, Jiang H, Chen J (2021) Caspase 3\/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity. Cell Death Dis 12(2):186. https:\/\/doi.org\/10.1038\/s41419-021-03458-5","journal-title":"Cell Death Dis"},{"issue":"24","key":"2379_CR35","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202101840","volume":"8","author":"Y Xiao","year":"2021","unstructured":"Xiao Y, Zhang T, Ma X, Yang QC, Yang LL, Yang SC, Liang M, Xu Z, Sun ZJ (2021) Microenvironment-responsive prodrug-induced pyroptosis boosts cancer immunotherapy. Adv Sci 8(24):e2101840. https:\/\/doi.org\/10.1002\/advs.202101840","journal-title":"Adv Sci"},{"issue":"12","key":"2379_CR36","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1038\/s41422-018-0090-y","volume":"28","author":"B Zhou","year":"2018","unstructured":"Zhou B, Zhang JY, Liu XS, Chen HZ, Ai YL, Cheng K, Sun RY, Zhou D, Han J, Wu Q (2018) Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis. Cell Res 28(12):1171. https:\/\/doi.org\/10.1038\/s41422-018-0090-y","journal-title":"Cell Res"},{"issue":"4","key":"2379_CR37","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.jmb.2007.03.072","volume":"369","author":"HJ Lee","year":"2007","unstructured":"Lee HJ, Oh YK, Rhee M, Lim JY, Hwang JY, Park YS, Kwon Y, Choi KH, Jo I, Park SI, Gao B, Kim WH (2007) The role of STAT1\/IRF-1 on synergistic ROS production and loss of mitochondrial transmembrane potential during hepatic cell death induced by LPS\/d-GalN. J Mol Biol 369(4):967. https:\/\/doi.org\/10.1016\/j.jmb.2007.03.072","journal-title":"J Mol Biol"},{"issue":"4","key":"2379_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101007","volume":"4","author":"N Perurena","year":"2023","unstructured":"Perurena N, Lock R, Davis RA, Raghavan S, Pilla NF, Ng R, Loi P, Guild CJ, Miller AL, Sicinska E, Cleary JM, Rubinson DA, Wolpin BM, Gray NS, Santagata S, Hahn WC, Morton JP, Sansom OJ, Aguirre AJ, Cichowski K (2023) USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities. Cell Rep Med 4(4):101007. https:\/\/doi.org\/10.1016\/j.xcrm.2023.101007","journal-title":"Cell Rep Med"},{"issue":"7","key":"2379_CR39","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1038\/s41418-021-00740-z","volume":"28","author":"X Jie","year":"2021","unstructured":"Jie X, Fong WP, Zhou R, Zhao Y, Zhao Y, Meng R, Zhang S, Dong X, Zhang T, Yang K, Wu G, Xu S (2021) USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-\u03b22 transcription. Cell Death Differ 28(7):2095. https:\/\/doi.org\/10.1038\/s41418-021-00740-z","journal-title":"Cell Death Differ"},{"issue":"6","key":"2379_CR40","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1002\/hep.20701","volume":"41","author":"D. E. Kleiner, E. M. Brunt, M. Van Natta, C. Behling, M. J. Contos, O. W. Cummings, L. D. Ferrell, Y. C. Liu, M. S. Torbenson, A. Unalp-Arida, M. Yeh, A. J. McCullough, A. J. Sanyal, N. Nonalcoholic Steatohepatitis Clinical Research","year":"2005","unstructured":"D. E. Kleiner, E. M. Brunt, M. Van Natta, C. Behling, M. J. Contos, O. W. Cummings, L. D. Ferrell, Y. C. Liu, M. S. Torbenson, A. Unalp-Arida, M. Yeh, A. J. McCullough, A. J. Sanyal, N. Nonalcoholic Steatohepatitis Clinical Research (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41(6):1313. https:\/\/doi.org\/10.1002\/hep.20701","journal-title":"Hepatology"},{"issue":"1","key":"2379_CR41","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1136\/jcp-2023-209190","volume":"78","author":"PM Lavrut","year":"2024","unstructured":"Lavrut PM, Guillaud O, Dumortier J, Mintz E, Brun V, Heissat S, Couchonnal Bedoya E, Lachaux A, Bost M, Hervieu V (2024) Histological features of liver disease development in the Atp7b(\u2212\/\u2212) mouse: a model of Wilson\u2019s disease. J Clin Pathol 78(1):51. https:\/\/doi.org\/10.1136\/jcp-2023-209190","journal-title":"J Clin Pathol"},{"issue":"7","key":"2379_CR42","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.1016\/j.ymthe.2023.02.023","volume":"31","author":"S Wang","year":"2023","unstructured":"Wang S, Wu ZZ, Zhu SW, Wan SC, Zhang MJ, Zhang BX, Yang QC, Xiao Y, Li H, Mao L, Wang ZY, Gutkind JS, Sun ZJ (2023) CTLA-4 blockade induces tumor pyroptosis via CD8(+) T cells in head and neck squamous cell carcinoma. Mol Ther 31(7):2154. https:\/\/doi.org\/10.1016\/j.ymthe.2023.02.023","journal-title":"Mol Ther"},{"key":"2379_CR43","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ecoenv.2019.02.069","volume":"174","author":"J Liao","year":"2019","unstructured":"Liao J, Yang F, Tang Z, Yu W, Han Q, Hu L, Li Y, Guo J, Pan J, Ma F, Ma X, Lin Y (2019) Inhibition of Caspase-1-dependent pyroptosis attenuates copper-induced apoptosis in chicken hepatocytes. Ecotoxicol Environ Saf 174:110. https:\/\/doi.org\/10.1016\/j.ecoenv.2019.02.069","journal-title":"Ecotoxicol Environ Saf"},{"issue":"4","key":"2379_CR44","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1021\/acs.jafc.1c07927","volume":"70","author":"J Liao","year":"2022","unstructured":"Liao J, Hu Z, Li Q, Li H, Chen W, Huo H, Han Q, Zhang H, Guo J, Hu L, Pan J, Li Y, Tang Z (2022) Endoplasmic reticulum stress contributes to copper-induced pyroptosis via regulating the IRE1alpha-XBP1 pathway in pig Jejunal epithelial cells. J Agric Food Chem 70(4):1293. https:\/\/doi.org\/10.1021\/acs.jafc.1c07927","journal-title":"J Agric Food Chem"},{"issue":"16","key":"2379_CR45","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305715","volume":"11","author":"SX Ouyang","year":"2024","unstructured":"Ouyang SX, Zhu JH, Cao Q, Liu J, Zhang Z, Zhang Y, Wu JW, Sun SJ, Fu JT, Chen YT, Tong J, Liu Y, Zhang JB, Shen FM, Li DJ, Wang P (2024) Gasdermin-E-dependent non-canonical pyroptosis promotes drug-induced liver failure by promoting cps1 deisgylation and degradation. Adv Sci 11(16):e2305715. https:\/\/doi.org\/10.1002\/advs.202305715","journal-title":"Adv Sci"},{"issue":"11","key":"2379_CR46","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/s41419-023-06221-0","volume":"14","author":"K Kadono","year":"2023","unstructured":"Kadono K, Kojima H, Yao S, Kageyama S, Nakamura K, Hirao H, Ito T, Dery KJ, Farmer DG, Kaldas FM, Li X, Kupiec-Weglinski JW (2023) SIRT1 regulates hepatocyte programmed cell death via GSDME\u2014IL18 axis in human and mouse liver transplantation. Cell Death Dis 14(11):762. https:\/\/doi.org\/10.1038\/s41419-023-06221-0","journal-title":"Cell Death Dis"},{"issue":"2","key":"2379_CR47","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1182\/blood-2007-03-082941","volume":"111","author":"Y Lee","year":"2008","unstructured":"Lee Y, Hyung SW, Jung HJ, Kim HJ, Staerk J, Constantinescu SN, Chang EJ, Lee ZH, Lee SW, Kim HH (2008) The ubiquitin-mediated degradation of Jak1 modulates osteoclastogenesis by limiting interferon-beta-induced inhibitory signaling. Blood 111(2):885. https:\/\/doi.org\/10.1182\/blood-2007-03-082941","journal-title":"Blood"},{"issue":"8","key":"2379_CR48","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1016\/j.cell.2026.03.024","volume":"189","author":"M Conrad","year":"2026","unstructured":"Conrad M, Strasser A, Jost PJ, Yuan J, Shao F, Vandenabeele P, Wahida A (2026) Cell death in cancer. Cell 189(8):2322. https:\/\/doi.org\/10.1016\/j.cell.2026.03.024","journal-title":"Cell"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-026-02379-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-026-02379-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-026-02379-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T17:02:04Z","timestamp":1784048524000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-026-02379-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["2379"],"URL":"https:\/\/doi.org\/10.1007\/s10495-026-02379-y","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,18]]},"assertion":[{"value":"13 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Animal Care and Use Committee (IACUC) of Beijing Friendship Hospital, Capital Medical University (Approval No. 24\u20132016). All animal procedures were performed in accordance with the Guide for the Care and Use of Laboratory Animals (National Institutes of Health, 8th edition) and relevant Chinese legislation on animal experimentation. Clinical trial number: not applicable.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experiments were repeated at least twice to validate the findings. Statistical analyses were performed using two-tailed unpaired Student\u2019s t-tests or one-way ANOVA, as appropriate. Mice were randomly assigned to treatment groups, and group allocation was blinded whenever possible until statistical analysis. No animals or potential outliers were excluded from the study. The data and analytical results generated in this study are available from the corresponding author upon reasonable request.","order":3,"name":"Ethics","label":"Data statement","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"177"}}