{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T17:12:18Z","timestamp":1784049138928,"version":"3.55.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["Project Code ECS_00000017 MUR Directoral Decree n.1055, 23 June 2022, CUP B83C22003930001"],"award-info":[{"award-number":["Project Code ECS_00000017 MUR Directoral Decree n.1055, 23 June 2022, CUP B83C22003930001"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["Project Code ECS_00000017 MUR Directoral Decree n.1055, 23 June 2022, CUP B83C22003930001"],"award-info":[{"award-number":["Project Code ECS_00000017 MUR Directoral Decree n.1055, 23 June 2022, CUP B83C22003930001"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009888","name":"Regione Toscana","doi-asserted-by":"publisher","award":["PRECISE-CLL"],"award-info":[{"award-number":["PRECISE-CLL"]}],"id":[{"id":"10.13039\/501100009888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009888","name":"Regione Toscana","doi-asserted-by":"publisher","award":["PRECISE-CLL"],"award-info":[{"award-number":["PRECISE-CLL"]}],"id":[{"id":"10.13039\/501100009888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["Grant Agreement ERC 951329"],"award-info":[{"award-number":["Grant Agreement ERC 951329"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["IG 2017 - ID. 20148"],"award-info":[{"award-number":["IG 2017 - ID. 20148"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s10495-026-02393-0","type":"journal-article","created":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:16:47Z","timestamp":1783149407000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Taginostat, a new quinolone-based HDAC6 inhibitor, promotes apoptosis of chronic lymphocytic leukemia cells in vitro and in vivo by activating STAT4"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4572-4737","authenticated-orcid":false,"given":"Vanessa","family":"Tatangelo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1619-3295","authenticated-orcid":false,"given":"Gabriele","family":"Carullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9510-9284","authenticated-orcid":false,"given":"Ludovica","family":"Lopresti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1710-7977","authenticated-orcid":false,"given":"Cristina","family":"Ulivieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9375-6242","authenticated-orcid":false,"given":"Simone","family":"Brogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8471-0880","authenticated-orcid":false,"given":"Stefania","family":"Butini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4260-5657","authenticated-orcid":false,"given":"Matteo","family":"Gatta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3653-8972","authenticated-orcid":false,"given":"Nagaja","family":"Capitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1836-960X","authenticated-orcid":false,"given":"Federica","family":"Rungo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0219-6315","authenticated-orcid":false,"given":"Maria Carmela","family":"Cavallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0769-6891","authenticated-orcid":false,"given":"Alessandro","family":"Gozzetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3538-3913","authenticated-orcid":false,"given":"Monica","family":"Bocchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4578-728X","authenticated-orcid":false,"given":"Monica","family":"Tozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5623-1288","authenticated-orcid":false,"given":"Sara","family":"Ciofini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8313-2417","authenticated-orcid":false,"given":"Sandra","family":"Gemma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4414-6744","authenticated-orcid":false,"given":"Cosima T","family":"Baldari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5295-9529","authenticated-orcid":false,"given":"Giuseppe","family":"Campiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1542-6955","authenticated-orcid":false,"given":"Laura","family":"Patrussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"key":"2393_CR1","doi-asserted-by":"publisher","first-page":"16096","DOI":"10.1038\/nrdp.2016.96","volume":"3","author":"TJ Kipps","year":"2017","unstructured":"Kipps TJ, Stevenson FK, Wu CJ et al (2017) Chronic lymphocytic leukaemia. Nat Rev Dis Prim 3:16096. https:\/\/doi.org\/10.1038\/nrdp.2016.96","journal-title":"Nat Rev Dis Prim"},{"key":"2393_CR2","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.3390\/cancers12041006","volume":"12","author":"L Patrussi","year":"2020","unstructured":"Patrussi L, Capitani N, Baldari CT (2020) P66Shc: A Pleiotropic Regulator of B Cell Trafficking and a Gatekeeper in Chronic Lymphocytic Leukemia. Cancers (Basel) 12:1006. https:\/\/doi.org\/10.3390\/cancers12041006","journal-title":"Cancers (Basel)"},{"key":"2393_CR3","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.3324\/haematol.2018.209981","volume":"104","author":"L Patrussi","year":"2019","unstructured":"Patrussi L, Capitani N, Ulivieri C et al (2019) p66Shc deficiency in the E\u00b5-TCL1 mouse model of chronic lymphocytic leukemia enhances leukemogenesis by altering the chemokine receptor landscape. Haematologica 104:2040\u20132052. https:\/\/doi.org\/10.3324\/haematol.2018.209981","journal-title":"Haematologica"},{"key":"2393_CR4","doi-asserted-by":"publisher","unstructured":"Tatangelo V, Boncompagni G, Capitani N et al (2022) p66Shc Deficiency in Chronic Lymphocytic Leukemia Promotes Chemokine Receptor Expression Through the ROS-Dependent Inhibition of NF-\u03baB. https:\/\/doi.org\/10.3389\/fonc.2022.877495. Front Oncol 12:","DOI":"10.3389\/fonc.2022.877495"},{"key":"2393_CR5","doi-asserted-by":"publisher","first-page":"57086","DOI":"10.18632\/oncotarget.10977","volume":"7","author":"F Cattaneo","year":"2016","unstructured":"Cattaneo F, Patrussi L, Capitani N et al (2016) Expression of the p66Shc protein adaptor is regulated by the activator of transcription STAT4 in normal and chronic lymphocytic leukemia B cells. Oncotarget 7:57086\u201357098. https:\/\/doi.org\/10.18632\/oncotarget.10977","journal-title":"Oncotarget"},{"key":"2393_CR6","doi-asserted-by":"crossref","unstructured":"Cirella A, Luri-Rey C, Di Trani CA et al (2022) Novel strategies exploiting interleukin-12 in cancer immunotherapy. Pharmacol Ther 239","DOI":"10.1016\/j.pharmthera.2022.108189"},{"key":"2393_CR7","doi-asserted-by":"publisher","first-page":"114920","DOI":"10.1016\/j.ejmech.2022.114920","volume":"245","author":"FF Yang","year":"2023","unstructured":"Yang FF, Hu T, Liu JQ et al (2023) Histone deacetylases (HDACs) as the promising immunotherapeutic targets for hematologic cancer treatment. Eur J Med Chem 245:114920. https:\/\/doi.org\/10.1016\/j.ejmech.2022.114920","journal-title":"Eur J Med Chem"},{"key":"2393_CR8","doi-asserted-by":"publisher","unstructured":"Lian B, Chen X, Shen K (2023) Inhibition of histone deacetylases attenuates tumor progression and improves immunotherapy in breast cancer. Front Immunol 14. https:\/\/doi.org\/10.3389\/FIMMU.2023.1164514","DOI":"10.3389\/FIMMU.2023.1164514"},{"key":"2393_CR9","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1093\/emboj\/cdg115","volume":"22","author":"Y Zhang","year":"2003","unstructured":"Zhang Y, Li N, Caron C et al (2003) HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J 22:1168\u20131179. https:\/\/doi.org\/10.1093\/emboj\/cdg115","journal-title":"EMBO J"},{"key":"2393_CR10","doi-asserted-by":"crossref","unstructured":"Chang P, Li H, Hu H et al (2021) The Role of HDAC6 in Autophagy and NLRP3 Inflammasome. Front Immunol 12","DOI":"10.3389\/fimmu.2021.763831"},{"key":"2393_CR11","doi-asserted-by":"publisher","first-page":"3012","DOI":"10.1182\/bloodadvances.2018020065","volume":"2","author":"K Maharaj","year":"2018","unstructured":"Maharaj K, Powers JJ, Achille A et al (2018) Silencing of HDAC6 as a therapeutic target in chronic lymphocytic leukemia. Blood Adv 2:3012\u20133024. https:\/\/doi.org\/10.1182\/bloodadvances.2018020065","journal-title":"Blood Adv"},{"key":"2393_CR12","doi-asserted-by":"publisher","first-page":"590072","DOI":"10.3389\/fimmu.2020.590072","volume":"11","author":"K Maharaj","year":"2020","unstructured":"Maharaj K, Powers JJ, Mediavilla-Varela M et al (2020) HDAC6 Inhibition Alleviates CLL-Induced T-Cell Dysfunction and Enhances Immune Checkpoint Blockade Efficacy in the E\u00b5-TCL1 Model. Front Immunol 11:590072. https:\/\/doi.org\/10.3389\/fimmu.2020.590072","journal-title":"Front Immunol"},{"key":"2393_CR13","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1002\/mc.22983","volume":"58","author":"DH Lee","year":"2019","unstructured":"Lee DH, Kim GW, Kwon SH (2019) The HDAC6-selective inhibitor is effective against non-Hodgkin lymphoma and synergizes with ibrutinib in follicular lymphoma. Mol Carcinog 58:944\u2013956. https:\/\/doi.org\/10.1002\/mc.22983","journal-title":"Mol Carcinog"},{"key":"2393_CR14","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1038\/s41418-022-01017-9","volume":"29","author":"YS Zhang","year":"2022","unstructured":"Zhang YS, Xin DE, Wang Z et al (2022) Acetylation licenses Th1 cell polarization to constrain Listeria monocytogenes infection. Cell Death Differ 29:2303\u20132315. https:\/\/doi.org\/10.1038\/s41418-022-01017-9","journal-title":"Cell Death Differ"},{"key":"2393_CR15","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1182\/blood-2017-09-806398","volume":"131","author":"M Hallek","year":"2018","unstructured":"Hallek M, Cheson BD, Catovsky D et al (2018) iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL. Blood 131:2745\u20132760. https:\/\/doi.org\/10.1182\/blood-2017-09-806398","journal-title":"Blood"},{"key":"2393_CR16","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.clml.2015.06.001","volume":"15","author":"A Visentin","year":"2015","unstructured":"Visentin A, Facco M, Frezzato F et al (2015) Integrated CLL Scoring System, a New and Simple Index to Predict Time to Treatment and Overall Survival in Patients with Chronic Lymphocytic Leukemia. Clin Lymphoma. Myeloma Leuk 15:612\u2013620e5. https:\/\/doi.org\/10.1016\/j.clml.2015.06.001","journal-title":"Myeloma Leuk"},{"key":"2393_CR17","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1053\/j.seminhematol.2024.05.002","volume":"61","author":"A Floerchinger","year":"2024","unstructured":"Floerchinger A, Seiffert M (2024) Lessons learned from the E\u00b5-TCL1 mouse model of CLL. Semin Hematol 61:194\u2013200. https:\/\/doi.org\/10.1053\/j.seminhematol.2024.05.002","journal-title":"Semin Hematol"},{"key":"2393_CR18","doi-asserted-by":"publisher","first-page":"109803","DOI":"10.1016\/j.cbi.2022.109803","volume":"353","author":"C Chen","year":"2022","unstructured":"Chen C, Liu A, Lu Q et al (2022) HDAC6 inhibitor ACY-1215 improves neuropathic pain and its comorbidities in rats of peripheral nerve injury by regulating neuroinflammation. Chem Biol Interact 353:109803. https:\/\/doi.org\/10.1016\/j.cbi.2022.109803","journal-title":"Chem Biol Interact"},{"key":"2393_CR19","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.clim.2015.11.007","volume":"162","author":"NL Regna","year":"2016","unstructured":"Regna NL, Vieson MD, Luo XM et al (2016) Specific HDAC6 inhibition by ACY-738 reduces SLE pathogenesis in NZB\/W mice. Clin Immunol 162:58\u201373. https:\/\/doi.org\/10.1016\/j.clim.2015.11.007","journal-title":"Clin Immunol"},{"key":"2393_CR20","doi-asserted-by":"publisher","first-page":"116537","DOI":"10.1016\/j.biopha.2024.116537","volume":"174","author":"S Rossi","year":"2024","unstructured":"Rossi S, Tatangelo V, Dichiara M et al (2024) A novel potent class I HDAC inhibitor reverses the STAT4\/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients. Biomed Pharmacother 174:116537. https:\/\/doi.org\/10.1016\/j.biopha.2024.116537","journal-title":"Biomed Pharmacother"},{"key":"2393_CR21","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1080\/19466315.2018.1437071","volume":"10","author":"Q Liu","year":"2018","unstructured":"Liu Q, Yin X, Languino LR, Altieri DC (2018) Evaluation of Drug Combination Effect Using a Bliss Independence Dose\u2013Response Surface Model. Stat Biopharm Res 10:112\u2013122. https:\/\/doi.org\/10.1080\/19466315.2018.1437071","journal-title":"Stat Biopharm Res"},{"key":"2393_CR22","doi-asserted-by":"publisher","unstructured":"Boncompagni G, Varone A, Tatangelo V et al (2022) Glycerophosphoinositol Promotes Apoptosis of Chronic Lymphocytic Leukemia Cells by Enhancing Bax Expression and Activation. Front Oncol 12. https:\/\/doi.org\/10.3389\/fonc.2022.835290","DOI":"10.3389\/fonc.2022.835290"},{"key":"2393_CR23","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/s41419-024-06528-6","volume":"15","author":"G Boncompagni","year":"2024","unstructured":"Boncompagni G, Tatangelo V, Lopresti L et al (2024) Leukemic cell-secreted interleukin-9 suppresses cytotoxic T cell-mediated killing in chronic lymphocytic leukemia. Cell Death Dis 15:144. https:\/\/doi.org\/10.1038\/s41419-024-06528-6","journal-title":"Cell Death Dis"},{"key":"2393_CR24","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1038\/s41388-017-0066-2","volume":"37","author":"L Patrussi","year":"2018","unstructured":"Patrussi L, Capitani N, Cattaneo F et al (2018) p66Shc deficiency enhances CXCR4 and CCR7 recycling in CLL B cells by facilitating their dephosphorylation-dependent release from \u03b2-arrestin at early endosomes. Oncogene 37:1534\u20131550. https:\/\/doi.org\/10.1038\/s41388-017-0066-2","journal-title":"Oncogene"},{"key":"2393_CR25","doi-asserted-by":"publisher","first-page":"9960","DOI":"10.1021\/acs.jmedchem.1c00184","volume":"64","author":"G Campiani","year":"2021","unstructured":"Campiani G, Cavella C, Osko JD et al (2021) Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors. J Med Chem 64:9960\u20139988. https:\/\/doi.org\/10.1021\/acs.jmedchem.1c00184","journal-title":"J Med Chem"},{"key":"2393_CR26","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1021\/acsmedchemlett.0c00395","volume":"11","author":"AP Saraswati","year":"2020","unstructured":"Saraswati AP, Relitti N, Brindisi M et al (2020) Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation. ACS Med Chem Lett 11:2268\u20132276. https:\/\/doi.org\/10.1021\/acsmedchemlett.0c00395","journal-title":"ACS Med Chem Lett"},{"key":"2393_CR27","doi-asserted-by":"publisher","unstructured":"Federico S, Khan T, Fontana A et al (2022) Azetidin-2-one-based small molecules as dual hHDAC6\/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability. Eur J Med Chem 238. https:\/\/doi.org\/10.1016\/j.ejmech.2022.114409","DOI":"10.1016\/j.ejmech.2022.114409"},{"key":"2393_CR28","doi-asserted-by":"publisher","first-page":"112998","DOI":"10.1016\/j.ejmech.2020.112998","volume":"212","author":"N Relitti","year":"2021","unstructured":"Relitti N, Saraswati AP, Chemi G et al (2021) Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation. Eur J Med Chem 212:112998. https:\/\/doi.org\/10.1016\/j.ejmech.2020.112998","journal-title":"Eur J Med Chem"},{"key":"2393_CR29","doi-asserted-by":"publisher","first-page":"14946","DOI":"10.1021\/acs.jmedchem.4c00477","volume":"67","author":"G Carullo","year":"2024","unstructured":"Carullo G, Orsini N, Piano I et al (2024) Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy. J Med Chem 67:14946\u201314973. https:\/\/doi.org\/10.1021\/acs.jmedchem.4c00477","journal-title":"J Med Chem"},{"key":"2393_CR30","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1021\/acsptsci.4c00456","volume":"8","author":"A Fontana","year":"2024","unstructured":"Fontana A, Bergantini L, Carullo G et al (2024) Spirotetrahydroisoquinoline-Based Histone Deacetylase Inhibitors as New Antifibrotic Agents: Biological Evaluation in Human Fibroblasts from Bronchoalveolar Lavages of Idiopathic Pulmonary Fibrosis Patients. ACS Pharmacol Transl Sci 8:380\u2013393. https:\/\/doi.org\/10.1021\/acsptsci.4c00456","journal-title":"ACS Pharmacol Transl Sci"},{"key":"2393_CR31","doi-asserted-by":"publisher","first-page":"100276","DOI":"10.1016\/j.ejmcr.2025.100276","volume":"14","author":"I Cursaro","year":"2025","unstructured":"Cursaro I, Ciccone V, Tudino V et al (2025) Reversing TGF-\u03b21-induced fibrotic phenotype in human lung fibroblasts using a PROTAC tool derived from an indoline-based HDAC6 inhibitor. Eur J Med Chem Rep 14:100276. https:\/\/doi.org\/10.1016\/j.ejmcr.2025.100276","journal-title":"Eur J Med Chem Rep"},{"key":"2393_CR32","first-page":"401","volume":"1863","author":"E ten Hacken","year":"2016","unstructured":"ten Hacken E, Burger JA (2016) Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: Implications for disease pathogenesis and treatment. Biochim. Biophys. Acta - Mol Cell Res 1863:401\u2013413","journal-title":"Acta - Mol Cell Res"},{"key":"2393_CR33","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.phrs.2017.11.004","volume":"129","author":"M Lernoux","year":"2018","unstructured":"Lernoux M, Schnekenburger M, Dicato M, Diederich M (2018) Anti-cancer effects of naturally derived compounds targeting histone deacetylase 6-related pathways. Pharmacol Res 129:337\u2013356","journal-title":"Pharmacol Res"},{"key":"2393_CR34","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.4161\/epi.6.10.17200","volume":"6","author":"A P\u00e9rez-Perarnau","year":"2011","unstructured":"P\u00e9rez-Perarnau A, Coll-Mulet L, Rubio-Pati\u00f1o C et al (2011) Analysis of apoptosis regulatory genes altered by histone deacetylase inhibitors in chronic lymphocytic leukemia cells. Epigenetics 6:1228\u20131235. https:\/\/doi.org\/10.4161\/epi.6.10.17200","journal-title":"Epigenetics"},{"key":"2393_CR35","doi-asserted-by":"publisher","first-page":"105965","DOI":"10.1016\/j.phrs.2021.105965","volume":"174","author":"F Vanni","year":"2021","unstructured":"Vanni F, Lopresti L, Zurli V et al (2021) A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in E\u00b5-TCL1 mice through the JNK\/STAT4\/p66Shc axis. Pharmacol Res 174:105965. https:\/\/doi.org\/10.1016\/j.phrs.2021.105965","journal-title":"Pharmacol Res"},{"key":"2393_CR36","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/med.21379","volume":"36","author":"Z Liu","year":"2016","unstructured":"Liu Z, Ding Y, Ye N et al (2016) Direct Activation of Bax Protein for Cancer Therapy. Med Res Rev 36:313\u2013341. https:\/\/doi.org\/10.1002\/med.21379","journal-title":"Med Res Rev"},{"key":"2393_CR37","doi-asserted-by":"crossref","unstructured":"Majeed NS, Salam AA, Farhan SR et al (2025) Multifaceted Roles of Bcl-2 Family Proteins: Regulatory Roles in Apoptosis, Physiological Functions, and Therapeutic Potential. Curr Med Sci 1\u201317","DOI":"10.1007\/s11596-025-00124-1"},{"key":"2393_CR38","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.tibs.2025.09.001","volume":"50","author":"L Hohorst","year":"2025","unstructured":"Hohorst L, Ros U, Garcia-Saez AJ (2025) Mitochondrial dynamics and pore formation in regulated cell death pathways. Trends Biochem Sci 50:1001\u20131014","journal-title":"Trends Biochem Sci"},{"key":"2393_CR39","doi-asserted-by":"publisher","first-page":"3726","DOI":"10.1182\/blood-2009-08-239244","volume":"115","author":"N Capitani","year":"2010","unstructured":"Capitani N, Lucherini OM, Sozzi E et al (2010) Impaired expression of p66Shc, a novel regulator of B-cell survival, in chronic lymphocytic leukemia. Blood 115:3726\u20133736. https:\/\/doi.org\/10.1182\/blood-2009-08-239244","journal-title":"Blood"},{"key":"2393_CR40","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1080\/08830185.2024.2395274","volume":"43","author":"M Tolomeo","year":"2024","unstructured":"Tolomeo M, Cascio A (2024) STAT4 and STAT6, their role in cellular and humoral immunity and in diverse human diseases. Int Rev Immunol 43:394\u2013418","journal-title":"Int Rev Immunol"},{"key":"2393_CR41","doi-asserted-by":"publisher","first-page":"117218","DOI":"10.1016\/j.biopha.2024.117218","volume":"178","author":"Z Huang","year":"2024","unstructured":"Huang Z, Li L, Cheng B, Li D (2024) Small molecules targeting HDAC6 for cancer treatment: Current progress and novel strategies. Biomed Pharmacother 178:117218","journal-title":"Biomed Pharmacother"},{"key":"2393_CR42","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3390\/pharmaceutics16010054","volume":"16","author":"A Vuleti\u0107","year":"2024","unstructured":"Vuleti\u0107 A, Mirja\u010di\u0107 Martinovi\u0107 K, Spasi\u0107 J (2024) Role of Histone Deacetylase 6 and Histone Deacetylase 6 Inhibition in Colorectal Cancer. Pharmaceutics 16:54","journal-title":"Pharmaceutics"},{"key":"2393_CR43","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.4161\/epi.22674","volume":"7","author":"M Van Damme","year":"2012","unstructured":"Van Damme M, Crompot E, Meuleman N et al (2012) HDAC isoenzyme expression is deregulated in chronic lymphocytic leukemia B-cells and has a complex prognostic significance. Epigenetics 7:1403\u20131412. https:\/\/doi.org\/10.4161\/epi.22674","journal-title":"Epigenetics"},{"key":"2393_CR44","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1182\/blood.2020005785","volume":"137","author":"L Patrussi","year":"2021","unstructured":"Patrussi L, Manganaro N, Capitani N et al (2021) Enhanced IL-9 secretion by p66Shc-deficient CLL cells modulates the chemokine landscape of the stromal microenvironment. Blood 137:2182\u20132195. https:\/\/doi.org\/10.1182\/blood.2020005785","journal-title":"Blood"},{"key":"2393_CR45","doi-asserted-by":"publisher","unstructured":"Severin F, Visentin, et al (2019) In Chronic Lymphocytic Leukemia the JAK2\/STAT3 Pathway Is Constitutively Activated and Its Inhibition Leads to CLL Cell Death Unaffected by the Protective Bone Marrow Microenvironment. Cancers (Basel) 111939. https:\/\/doi.org\/10.3390\/cancers11121939","DOI":"10.3390\/cancers11121939"},{"key":"2393_CR46","doi-asserted-by":"crossref","unstructured":"Shah PV, Gladstone DE (2025) Covalent and Non-Covalent BTK Inhibition in Chronic Lymphocytic Leukemia Treatment. Curr Treat Options Oncol. 1\u201310","DOI":"10.1007\/s11864-025-01339-z"},{"key":"2393_CR47","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/S0140-6736(24)00595-6","volume":"404","author":"N Jain","year":"2024","unstructured":"Jain N, Wierda WG, O\u2019Brien S (2024) Chronic lymphocytic leukaemia. Lancet 404:694\u2013706","journal-title":"Lancet"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-026-02393-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-026-02393-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-026-02393-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T17:03:14Z","timestamp":1784048594000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-026-02393-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["2393"],"URL":"https:\/\/doi.org\/10.1007\/s10495-026-02393-0","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"186"}}