{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:18:40Z","timestamp":1791908320086,"version":"4.3.4"},"reference-count":121,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s10495-026-02416-w","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T09:22:09Z","timestamp":1786353729000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic cell death: ferroptosis, cuproptosis, and disulfidptosis as a unified framework for targeting metabolic vulnerabilities in disease"],"prefix":"10.1007","volume":"31","author":[{"given":"YaQi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SongYu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GuangDong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChengXin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"2416_CR1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41568-025-00879-8","volume":"26","author":"C Mao","year":"2026","unstructured":"Mao C, Jiang D, Koong AC, Gan B (2026) Exploiting metabolic cell death for cancer therapy. Nat Rev Cancer 26:27\u201345","journal-title":"Nat Rev Cancer"},{"key":"2416_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05930-w","volume":"14","author":"Z Chen","year":"2023","unstructured":"Chen Z, Wang W, Abdul Razak SR, Han T, Ahmad NH, Li X (2023) Ferroptosis as a potential target for cancer therapy. Cell Death Dis 14:460","journal-title":"Cell Death Dis"},{"key":"2416_CR3","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1126\/science.abf0529","volume":"375","author":"P Tsvetkov","year":"2022","unstructured":"Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M et al (2022) Copper induces cell death by targeting lipoylated TCA cycle proteins. Science 375:1254\u20131261","journal-title":"Science"},{"key":"2416_CR4","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41422-022-00653-7","volume":"32","author":"D Tang","year":"2022","unstructured":"Tang D, Chen X, Kroemer G (2022) Cuproptosis: a copper-triggered modality of mitochondrial cell death. Cell Res 32:417\u2013418","journal-title":"Cell Res"},{"key":"2416_CR5","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s41556-023-01091-2","volume":"25","author":"X Liu","year":"2023","unstructured":"Liu X, Nie L, Zhang Y, Yan Y, Wang C, Colic M et al (2023) Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nat Cell Biol 25:404\u2013414","journal-title":"Nat Cell Biol"},{"key":"2416_CR6","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1056\/NEJMoa1513257","volume":"374","author":"AW Roberts","year":"2016","unstructured":"Roberts AW, Davids MS, Pagel JM, Kahl BS, Puvvada SD, Gerecitano JF et al (2016) Targeting BCL2 with Venetoclax in relapsed chronic lymphocytic leukemia. N Engl J Med 374:311\u2013322","journal-title":"N Engl J Med"},{"key":"2416_CR7","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/s41571-020-0341-y","volume":"17","author":"BA Carneiro","year":"2020","unstructured":"Carneiro BA, El-Deiry WS (2020) Targeting apoptosis in cancer therapy. Nat Rev Clin Oncol 17:395\u2013417","journal-title":"Nat Rev Clin Oncol"},{"key":"2416_CR8","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","volume":"25","author":"L Galluzzi","year":"2018","unstructured":"Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P et al (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ 25:486\u2013541","journal-title":"Cell Death Differ"},{"key":"2416_CR9","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41435-026-00388-0","volume":"27","author":"M Bhardwaj","year":"2026","unstructured":"Bhardwaj M, Upmanyu K, Upadhyay S (2026) PANoptosis as a drug discovery framework: integrating cell death architecture with clinical translation. Genes Immun 27:141\u2013156","journal-title":"Genes Immun"},{"key":"2416_CR10","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/imr.12534","volume":"277","author":"SM Man","year":"2017","unstructured":"Man SM, Karki R, Kanneganti TD (2017) Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunol Rev 277:61\u201375","journal-title":"Immunol Rev"},{"key":"2416_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cytogfr.2025.09.003","volume":"86","author":"K Upmanyu","year":"2025","unstructured":"Upmanyu K, Upadhyay S (2025) Wiring and rewiring PANoptosis: molecular vulnerabilities for targeting inflammatory cell death in human disease. Cytokine Growth Factor Rev 86:1\u201316","journal-title":"Cytokine Growth Factor Rev"},{"key":"2416_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0299577","volume":"19","author":"SM Choudhury","year":"2024","unstructured":"Choudhury SM, Sarkar R, Karki R, Kanneganti TD (2024) A comparative study of apoptosis, pyroptosis, necroptosis, and PANoptosis components in mouse and human cells. PLoS ONE 19:e0299577","journal-title":"PLoS ONE"},{"key":"2416_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41540-026-00682-7","author":"S Gupta","year":"2026","unstructured":"Gupta S (2026) The p21 resilience network: a conceptual framework linking senescence to ferroptosis and cuproptosis resistance. NPJ Syst Biol Appl. https:\/\/doi.org\/10.1038\/s41540-026-00682-7","journal-title":"NPJ Syst Biol Appl"},{"key":"2416_CR14","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1038\/s41418-023-01153-w","volume":"30","author":"I Vitale","year":"2023","unstructured":"Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D et al (2023) Apoptotic cell death in disease\u2014current understanding of the NCCD 2023. Cell Death Differ 30:1097\u20131154","journal-title":"Cell Death Differ"},{"key":"2416_CR15","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1093\/procel\/pwae003","volume":"15","author":"C Mao","year":"2024","unstructured":"Mao C, Wang M, Zhuang L, Gan B (2024) Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond. Protein Cell 15:642\u2013660","journal-title":"Protein Cell"},{"key":"2416_CR16","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060\u20131072","journal-title":"Cell"},{"key":"2416_CR17","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41571-026-01128-z","volume":"23","author":"R Kang","year":"2026","unstructured":"Kang R, Liu J, Wang J, Kroemer G, Tang D (2026) Translating ferroptosis into oncology: challenges, opportunities and future directions. Nat Rev Clin Oncol 23:401\u2013424","journal-title":"Nat Rev Clin Oncol"},{"key":"2416_CR18","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","volume":"156","author":"S Yang Wan","year":"2014","unstructured":"Yang Wan S, SriRamaratnam R, Welsch Matthew E, Shimada K, Skouta R, Viswanathan Vasanthi S et al (2014) Regulation of Ferroptotic Cancer Cell Death by GPX4. Cell 156:317\u2013331","journal-title":"Cell"},{"key":"2416_CR19","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nchembio.2239","volume":"13","author":"S Doll","year":"2017","unstructured":"Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I et al (2017) ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol 13:91\u201398","journal-title":"Nat Chem Biol"},{"key":"2416_CR20","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","volume":"575","author":"K Bersuker","year":"2019","unstructured":"Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH et al (2019) The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575:688\u2013692","journal-title":"Nature"},{"key":"2416_CR21","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/s41568-022-00459-0","volume":"22","author":"G Lei","year":"2022","unstructured":"Lei G, Zhuang L, Gan B (2022) Targeting ferroptosis as a vulnerability in cancer. Nat Rev Cancer 22:381\u2013396","journal-title":"Nat Rev Cancer"},{"key":"2416_CR22","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","volume":"185","author":"BR Stockwell","year":"2022","unstructured":"Stockwell BR (2022) Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications. Cell 185:2401\u20132421","journal-title":"Cell"},{"key":"2416_CR23","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.cell.2011.10.033","volume":"147","author":"Y Fuchs","year":"2011","unstructured":"Fuchs Y, Steller H (2011) Programmed cell death in animal development and disease. Cell 147:742\u2013758","journal-title":"Cell"},{"key":"2416_CR24","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature13148","volume":"509","author":"JD Mancias","year":"2014","unstructured":"Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC (2014) Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature 509:105\u2013109","journal-title":"Nature"},{"key":"2416_CR25","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","volume":"6","author":"VAN Kraft","year":"2020","unstructured":"Kraft VAN, Bezjian CT, Pfeiffer S, Ringelstetter L, M\u00fcller C, Zandkarimi F et al (2020) GTP cyclohydrolase 1\/tetrahydrobiopterin counteract ferroptosis through lipid remodeling. ACS Cent Sci 6:41\u201353","journal-title":"ACS Cent Sci"},{"key":"2416_CR26","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/nchembio.2079","volume":"12","author":"K Shimada","year":"2016","unstructured":"Shimada K, Skouta R, Kaplan A, Yang WS, Hayano M, Dixon SJ et al (2016) Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol 12:497\u2013503","journal-title":"Nat Chem Biol"},{"key":"2416_CR27","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.tcb.2020.02.009","volume":"30","author":"BR Stockwell","year":"2020","unstructured":"Stockwell BR, Jiang X, Gu W (2020) Emerging mechanisms and disease relevance of ferroptosis. Trends Cell Biol 30:478\u2013490","journal-title":"Trends Cell Biol"},{"key":"2416_CR28","doi-asserted-by":"publisher","first-page":"869794","DOI":"10.3389\/fphar.2022.869794","volume":"13","author":"H Jiang","year":"2022","unstructured":"Jiang H, Zhang X, Yang W, Li M, Wang G, Luo Q (2022) Ferrostatin-1 ameliorates liver dysfunction via reducing iron in thioacetamide-induced acute liver injury in mice. Front Pharmacol 13:869794","journal-title":"Front Pharmacol"},{"key":"2416_CR29","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1073\/pnas.1821022116","volume":"116","author":"X Fang","year":"2019","unstructured":"Fang X, Wang H, Han D, Xie E, Yang X, Wei J et al (2019) Ferroptosis as a target for protection against cardiomyopathy. Proc Natl Acad Sci USA 116:2672\u20132680","journal-title":"Proc Natl Acad Sci USA"},{"key":"2416_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2026.03.016","author":"H Peng","year":"2026","unstructured":"Peng H, Tang C, Zhao M, Qin Z, Gong J, Xu X (2026) Brg1 interacts with liver X receptor and H3K18la to regulate ferroptosis via the CYP4A14\/20-HETE axis in liver transplantation. Am J Transplant. https:\/\/doi.org\/10.1016\/j.ajt.2026.03.016","journal-title":"Am J Transplant"},{"key":"2416_CR31","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.cmet.2024.10.006","volume":"37","author":"X Zha","year":"2025","unstructured":"Zha X, Liu X, Wei M, Huang H, Cao J, Liu S et al (2025) Microbiota-derived lysophosphatidylcholine alleviates Alzheimer\u2019s disease pathology via suppressing ferroptosis. Cell Metab 37:169\u201386.e9","journal-title":"Cell Metab"},{"key":"2416_CR32","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.nbd.2016.05.011","volume":"94","author":"B Do Van","year":"2016","unstructured":"Do Van B, Gouel F, Jonneaux A, Timmerman K, Gel\u00e9 P, P\u00e9trault M et al (2016) Ferroptosis, a newly characterized form of cell death in Parkinson\u2019s disease that is regulated by PKC. Neurobiol Dis 94:169\u2013178","journal-title":"Neurobiol Dis"},{"key":"2416_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2025.100916","volume":"49","author":"C-C Liu","year":"2026","unstructured":"Liu C-C, Lin J-H, Hsu T-W, Wang C-Y, Hsu H-S (2026) Inhibition of the 4-hydroxynonenal-regulated JNK\/c-Jun pathway improves bleomycin-induced lung fibrosis. Biomed J 49:100916","journal-title":"Biomed J"},{"key":"2416_CR34","doi-asserted-by":"publisher","first-page":"16836","DOI":"10.1073\/pnas.1415518111","volume":"111","author":"A Linkermann","year":"2014","unstructured":"Linkermann A, Skouta R, Himmerkus N, Mulay SR, Dewitz C, De Zen F et al (2014) Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci USA 111:16836\u201316841","journal-title":"Proc Natl Acad Sci USA"},{"key":"2416_CR35","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.cmet.2022.01.007","volume":"34","author":"NN Pavlova","year":"2022","unstructured":"Pavlova NN, Zhu J, Thompson CB (2022) The hallmarks of cancer metabolism: still emerging. Cell Metab 34:355\u2013377","journal-title":"Cell Metab"},{"key":"2416_CR36","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13045-019-0720-y","volume":"12","author":"Y Mou","year":"2019","unstructured":"Mou Y, Wang J, Wu J, He D, Zhang C, Duan C et al (2019) Ferroptosis, a new form of cell death: opportunities and challenges in cancer. J Hematol Oncol 12:34","journal-title":"J Hematol Oncol"},{"key":"2416_CR37","doi-asserted-by":"publisher","first-page":"517","DOI":"10.18632\/oncoscience.160","volume":"2","author":"N Eling","year":"2015","unstructured":"Eling N, Reuter L, Hazin J, Hamacher-Brady A, Brady NR (2015) Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells. Oncoscience 2:517\u2013532","journal-title":"Oncoscience"},{"key":"2416_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14121411","author":"I Artusi","year":"2025","unstructured":"Artusi I, Rubin M, Cravin G, Cozza G (2025) Ferroptosis in human diseases: fundamental roles and emerging therapeutic perspectives. Antioxidants (Basel). https:\/\/doi.org\/10.3390\/antiox14121411","journal-title":"Antioxidants (Basel)"},{"key":"2416_CR39","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1038\/nnano.2016.168","volume":"11","author":"S Zanganeh","year":"2016","unstructured":"Zanganeh S, Hutter G, Spitler R, Lenkov O, Mahmoudi M, Shaw A et al (2016) Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues. Nat Nanotechnol 11:986\u2013994","journal-title":"Nat Nanotechnol"},{"key":"2416_CR40","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.7150\/thno.124189","volume":"16","author":"L Subedi","year":"2026","unstructured":"Subedi L, Im IH, Bamjan AD, Jeon J, Phuyal S, Jeong YH et al (2026) Ligand-directed oral lipidic nanoplatform enables sustained ferroptosis and immune reprogramming via multivalent transporter-mediated metronomic delivery. Theranostics 16:2952\u20132983","journal-title":"Theranostics"},{"key":"2416_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123096","volume":"317","author":"M Li","year":"2025","unstructured":"Li M, Li Y, Yao X, Liu Y, Cai K, Yang H et al (2025) Optically controllable nanoregulators enable tumor-specific pro-ferroptosis lipometabolic reprogramming for in-situ adjuvant-free vaccination. Biomaterials 317:123096","journal-title":"Biomaterials"},{"key":"2416_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1528986","volume":"16","author":"Z Zeng","year":"2025","unstructured":"Zeng Z, Deng J, Wang G, Luo Z, Xiao W, Xie W et al (2025) Ferroptosis-related protein biomarkers for diagnosis, differential diagnosis, and short-term mortality in patients with sepsis in the intensive care unit. Front Immunol 16:1528986","journal-title":"Front Immunol"},{"key":"2416_CR43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2006203","volume":"16","author":"H Feng","year":"2018","unstructured":"Feng H, Stockwell BR (2018) Unsolved mysteries: how does lipid peroxidation cause ferroptosis? PLoS Biol 16:e2006203","journal-title":"PLoS Biol"},{"key":"2416_CR44","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202201406","volume":"7","author":"Q Meng","year":"2023","unstructured":"Meng Q, Ding B, Ma P, Lin J (2023) Interrelation between programmed cell death and immunogenic cell death: take antitumor nanodrug as an example. Small Methods 7:2201406","journal-title":"Small Methods"},{"key":"2416_CR45","doi-asserted-by":"publisher","first-page":"4274","DOI":"10.1038\/s41467-025-59531-6","volume":"16","author":"A Garcia-Gimenez","year":"2025","unstructured":"Garcia-Gimenez A, Ditcham JE, Azazi DMA, Giotopoulos G, Asby R, Meduri E et al (2025) CREBBP inactivation sensitizes B cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition. Nat Commun 16:4274","journal-title":"Nat Commun"},{"key":"2416_CR46","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41420-024-01800-2","volume":"10","author":"X Yu","year":"2024","unstructured":"Yu X, Wang Y, Tan J, Li Y, Yang P, Liu X et al (2024) Inhibition of NRF2 enhances the acute myeloid leukemia cell death induced by venetoclax via the ferroptosis pathway. Cell Death Discov 10:35","journal-title":"Cell Death Discov"},{"key":"2416_CR47","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.freeradbiomed.2025.03.031","volume":"233","author":"J Shi","year":"2025","unstructured":"Shi J, Cheng Y, Wang L, Xing W, Li Y, Sun X et al (2025) SR-B1 deficiency suppresses progression in acute myeloid leukemia via ferroptosis and reverses resistance to venetoclax. Free Radic Biol Med 233:24\u201338","journal-title":"Free Radic Biol Med"},{"key":"2416_CR48","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.1038\/s41418-025-01514-7","volume":"32","author":"Y Qiu","year":"2025","unstructured":"Qiu Y, H\u00fcther JA, Wank B, Rath A, Tykwe R, Aldrovandi M et al (2025) Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics. Cell Death Differ 32:1970\u20131985","journal-title":"Cell Death Differ"},{"key":"2416_CR49","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.tcb.2023.07.009","volume":"34","author":"X Liu","year":"2024","unstructured":"Liu X, Zhuang L, Gan B (2024) Disulfidptosis: disulfide stress\u2013induced cell death. Trends Cell Biol 34:327\u2013337","journal-title":"Trends Cell Biol"},{"key":"2416_CR50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27010451","volume":"27","author":"Y Wu","year":"2026","unstructured":"Wu Y, Zhang W, Jiang S, Liu S, Su J, Sun L (2026) LRPPRC-driven oxidative phosphorylation is associated with elesclomol-induced cuproptosis in ovarian cancer. Int J Mol Sci 27:451","journal-title":"Int J Mol Sci"},{"key":"2416_CR51","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01229-y","volume":"7","author":"L Chen","year":"2022","unstructured":"Chen L, Min J, Wang F (2022) Copper homeostasis and cuproptosis in health and disease. Signal Transduct Target Ther 7:378","journal-title":"Signal Transduct Target Ther"},{"key":"2416_CR52","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1016\/j.molcel.2022.05.001","volume":"82","author":"PA Cobine","year":"2022","unstructured":"Cobine PA, Brady DC (2022) Cuproptosis: cellular and molecular mechanisms underlying copper-induced cell death. Mol Cell 82:1786\u20131787","journal-title":"Mol Cell"},{"key":"2416_CR53","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02968-6","volume":"22","author":"Y Wang","year":"2024","unstructured":"Wang Y, Zhou Q, Luo W, Yang X, Zhang J, Lou Y et al (2024) A collagenase-decorated Cu-based nanotheranostics: remodeling extracellular matrix for optimizing cuproptosis and MRI in pancreatic ductal adenocarcinoma. J Nanobiotechnol 22:689","journal-title":"J Nanobiotechnol"},{"key":"2416_CR54","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.freeradbiomed.2025.01.042","volume":"229","author":"X Ning","year":"2025","unstructured":"Ning X, Chen X, Li R, Li Y, Lin Z, Yin Y (2025) Identification of a novel cuproptosis inducer that induces ER stress and oxidative stress to trigger immunogenic cell death in tumors. Free Radic Biol Med 229:276\u2013288","journal-title":"Free Radic Biol Med"},{"key":"2416_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2025.106906","volume":"187","author":"X Yang","year":"2025","unstructured":"Yang X, Bao Q, Xiao S, Pan M, Hu D, Zhou J et al (2025) Anti-colorectal cancer bioactive metabolites from endophytic fungi of Pyrola spp. targeting p-ATM\/P53 pathway driven by in vitro experiments and network pharmacology. Fitoterapia 187:106906","journal-title":"Fitoterapia"},{"key":"2416_CR56","doi-asserted-by":"publisher","DOI":"10.1007\/s13659-025-00569-w","volume":"16","author":"Y Kuang","year":"2026","unstructured":"Kuang Y, Lu B-H, Wu J-Y, Wu S-Y, Fu H-Y, Nan Q-Y et al (2026) The ethyl acetate extract from Trichoderma viride fermentation acts by downregulating the leukocyte transendothelial migration signaling pathway to induce ferroptosis in triple-negative breast cancer cells. Nat Prod Bioprospect 16:15","journal-title":"Nat Prod Bioprospect"},{"key":"2416_CR57","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.freeradbiomed.2025.06.017","volume":"237","author":"G Chen","year":"2025","unstructured":"Chen G, Wei M, Zhao C-Y, Zhang A-Y, Su J-B, Ni Z-R et al (2025) Phillygenin ameliorates myocardial ischemia-reperfusion injury by inhibiting cuproptosis via the autophagy-lysosome degradation of CTR1. Free Radic Biol Med 237:542\u2013557","journal-title":"Free Radic Biol Med"},{"key":"2416_CR58","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202415325","volume":"12","author":"H Tian","year":"2025","unstructured":"Tian H, Sun S, Qiu X, Wang J, Gao Y, Chen J et al (2025) Diallyl trisulfide from garlic regulates RAB18 phase separation to inhibit lipophagy and induce cuproptosis in hepatic stellate cells for antifibrotic effects. Adv Sci 12:2415325","journal-title":"Adv Sci"},{"key":"2416_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157091","volume":"146","author":"Z Li","year":"2025","unstructured":"Li Z, Huang Z, Liao X, Li H (2025) Columbianadin targets TRIM7 to maintain P2X7 palmitoylation, inhibiting cuproptosis in synovial M2 macrophages. Phytomedicine 146:157091","journal-title":"Phytomedicine"},{"key":"2416_CR60","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c10336","author":"W Li","year":"2024","unstructured":"Li W, Wang H, Liu Y, Li B, Wang F, Ye P et al (2024) \u201cTrinity\u201d comprehensively regulates the tumor microenvironment of lipid-coated CaCO3@CuO2 nanoparticles induces \u201ccuproptosis\u201d in HCC. ACS Appl Mater Interfaces. https:\/\/doi.org\/10.1021\/acsami.4c10336","journal-title":"ACS Appl Mater Interfaces"},{"key":"2416_CR61","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202504228","volume":"37","author":"J Huang","year":"2025","unstructured":"Huang J, Hu F, Zhang H, Cao Z, Xiao H, Yang Z et al (2025) Ultrasound-triggered nanoparticles induce cuproptosis for enhancing immunogenic sonodynamic therapy. Adv Mater 37:2504228","journal-title":"Adv Mater"},{"key":"2416_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101745","volume":"32","author":"X Yi","year":"2025","unstructured":"Yi X, Xie H, Huang K, Luo J, Li W, Zeng Q et al (2025) Tumor-targeting nanomaterials based on metal-organic frameworks mediate tumor immunotherapy by promoting cuproptosis and pyroptosis in hepatocellular carcinoma cells. Mater Today Bio 32:101745","journal-title":"Mater Today Bio"},{"key":"2416_CR63","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.actbio.2025.07.013","volume":"202","author":"W Chen","year":"2025","unstructured":"Chen W, Lin C, Gao Z, Huang Y, Wang X, Zhang Q et al (2025) A tumor microenvironment-responsive nanocomposite for enhanced copper retention and hypoxia reversal to promote cuproptosis in tumor treatment. Acta Biomater 202:463\u2013475","journal-title":"Acta Biomater"},{"key":"2416_CR64","doi-asserted-by":"publisher","first-page":"1633711","DOI":"10.3389\/fimmu.2025.1633711","volume":"16","author":"H Chen","year":"2025","unstructured":"Chen H, Li D, Zhang H, Zhang M, Lin Y, He H et al (2025) Mechanisms of copper metabolism and cuproptosis: implications for liver diseases. Front Immunol 16:1633711","journal-title":"Front Immunol"},{"key":"2416_CR65","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1688554","volume":"17","author":"F Tao","year":"2025","unstructured":"Tao F, Lin M, Meng X, Huang L, Zhuo B, Jiang S et al (2025) Copper homeostasis and cuproptosis: implications for neurodegenerative diseases. Front Aging Neurosci 17:1688554","journal-title":"Front Aging Neurosci"},{"key":"2416_CR66","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1038\/s41418-024-01341-2","volume":"31","author":"Y-T Liu","year":"2024","unstructured":"Liu Y-T, Chen L, Li S-J, Wang W-Y, Wang Y-Y, Yang Q-C et al (2024) Dysregulated Wnt\/\u03b2-catenin signaling confers resistance to cuproptosis in cancer cells. Cell Death Differ 31:1452\u20131466","journal-title":"Cell Death Differ"},{"key":"2416_CR67","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.tem.2025.06.007","volume":"37","author":"Y Li","year":"2026","unstructured":"Li Y, Wang X (2026) A metabolic perspective on cuproptosis. Trends Endocrinol Metab 37:277\u2013287","journal-title":"Trends Endocrinol Metab"},{"key":"2416_CR68","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/s41556-020-0496-x","volume":"22","author":"X Liu","year":"2020","unstructured":"Liu X, Olszewski K, Zhang Y, Lim EW, Shi J, Zhang X et al (2020) Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nat Cell Biol 22:476\u2013486","journal-title":"Nat Cell Biol"},{"key":"2416_CR69","doi-asserted-by":"publisher","first-page":"14233","DOI":"10.1021\/acsnano.5c00730","volume":"19","author":"M Zhang","year":"2025","unstructured":"Zhang M, Zheng H, Zhu X, Liu S, Jin H, Chen Y et al (2025) Synchronously evoking disulfidptosis and ferroptosis via systematical glucose deprivation targeting SLC7A11\/GSH\/GPX4 antioxidant axis. ACS Nano 19:14233\u201314248","journal-title":"ACS Nano"},{"key":"2416_CR70","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01871-9","volume":"22","author":"T Li","year":"2024","unstructured":"Li T, Song Y, Wei L, Song X, Duan R (2024) Disulfidptosis: a novel cell death modality induced by actin cytoskeleton collapse and a promising target for cancer therapeutics. Cell Commun Signal 22:491","journal-title":"Cell Commun Signal"},{"key":"2416_CR71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.acr.2024.04.001","volume":"162","author":"ESJ Arn\u00e9r","year":"2024","unstructured":"Arn\u00e9r ESJ, Schmidt EE (2024) Unresolved questions regarding cellular cysteine sources and their possible relationships to ferroptosis. Adv Cancer Res 162:1\u201344","journal-title":"Adv Cancer Res"},{"key":"2416_CR72","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102649","volume":"24","author":"P Koppula","year":"2021","unstructured":"Koppula P, Olszewski K, Zhang Y, Kondiparthi L, Liu X, Lei G et al (2021) KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition. iScience 24:102649","journal-title":"iScience"},{"key":"2416_CR73","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-024-00535-0","volume":"13","author":"J Wang","year":"2024","unstructured":"Wang J, Wang M, Wu S, Zhu Y, Fan K, Chen Y et al (2024) Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels. Oncogenesis 13:31","journal-title":"Oncogenesis"},{"key":"2416_CR74","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1038\/s41556-025-01673-2","volume":"27","author":"J Wan","year":"2025","unstructured":"Wan J, Shi J-H, Shi M, Huang H, Zhang Z, Li W et al (2025) Lactate dehydrogenase B facilitates disulfidptosis and exhaustion of tumour-infiltrating CD8+ T cells. Nat Cell Biol 27:972\u2013982","journal-title":"Nat Cell Biol"},{"key":"2416_CR75","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2025.137611","volume":"693","author":"QM Zhou","year":"2025","unstructured":"Zhou QM, Lu YF, Yang XY, Zhang JG, Wang YN, Luo WP et al (2025) Redox-driven hybrid nanoenzyme dynamically activating ferroptosis and disulfidptosis for hepatocellular carcinoma theranostics. J Colloid Interface Sci 693:137611","journal-title":"J Colloid Interface Sci"},{"key":"2416_CR76","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123592","volume":"325","author":"Z Wu","year":"2026","unstructured":"Wu Z, Gao M, Li Q, Lan H, Zheng Y, Zheng S et al (2026) Copper metal-organic framework-based multifaceted strategy for boosting cancer therapy via synergistic cuproptosis and disulfidptosis. Biomaterials 325:123592","journal-title":"Biomaterials"},{"key":"2416_CR77","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.bioactmat.2025.09.003","volume":"54","author":"M Zhang","year":"2025","unstructured":"Zhang M, Zheng H, Jin H, Zhu X, Liu S, Chen Y et al (2025) Regulating SLC7A11\/GSH\/GPX4 axis by glucose dyshomeostasis to simultaneously promote disulfidptosis, cuproptosis and ferroptosis. Bioactive Mater 54:744\u2013758","journal-title":"Bioactive Mater"},{"key":"2416_CR78","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2025.115094","volume":"257","author":"Z Ye","year":"2026","unstructured":"Ye Z, Yao Y, Xu Y, Ye J, Yao Q, Kou L et al (2026) Nanomedicine strategies for disulfidptosis activation in SLC7A11-high tumors. Colloids Surf B Biointerfaces 257:115094","journal-title":"Colloids Surf B Biointerfaces"},{"key":"2416_CR79","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.170749","volume":"526","author":"J Ruan","year":"2025","unstructured":"Ruan J, Li C, Wang Y, Wang C, Yang X, Xu C et al (2025) NADPH oxidase-mimicking nanozyme for disulfidptosis-induction strategy to amplify cuproptosis in cancer therapy. Chem Eng J 526:170749","journal-title":"Chem Eng J"},{"key":"2416_CR80","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60015-w","volume":"16","author":"W Yu","year":"2025","unstructured":"Yu W, Jin D, Zhang Y, Wang S, Yu J, Liu M et al (2025) Provoking tumor disulfidptosis by single-atom nanozyme via regulating cellular energy supply and reducing power. Nat Commun 16:4877","journal-title":"Nat Commun"},{"key":"2416_CR81","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-026-03032-y","author":"H Huang","year":"2026","unstructured":"Huang H, He Y, Chen J, Liao Y, Mo S, Qin W et al (2026) RRx-001 inhibits G6PD to deplete NADPH and trigger disulfidptosis coupled with DAMP-mediated immunogenic cell death in hepatocellular carcinoma. Cell Death Discov. https:\/\/doi.org\/10.1038\/s41420-026-03032-y","journal-title":"Cell Death Discov"},{"key":"2416_CR82","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-026-02783-6","author":"H Wang","year":"2026","unstructured":"Wang H, Qi Y, Zhou Y, Xia W, Dong Y, Ren L et al (2026) Disulfidptosis induced by intermittent fasting and metformin enhances the efficacy of anti-PD-1 therapy in renal cancer. Cell Commun Signal. https:\/\/doi.org\/10.1186\/s12964-026-02783-6","journal-title":"Cell Commun Signal"},{"key":"2416_CR83","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1038\/s41418-024-01440-0","volume":"32","author":"M Tang","year":"2025","unstructured":"Tang M, Dirks K, Kim SY, Qiu Z, Gao Y, Sun D et al (2025) Inhibition of thioredoxin reductase 1 sensitizes glucose-starved glioblastoma cells to disulfidptosis. Cell Death Differ 32:598\u2013612","journal-title":"Cell Death Differ"},{"key":"2416_CR84","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e34516","volume":"10","author":"L Yang","year":"2024","unstructured":"Yang L, Yuan L, Liu G (2024) Comprehensive evaluation of disulfidptosis in intestinal immunity and biologic therapy response in Ulcerative Colitis. Heliyon 10:e34516","journal-title":"Heliyon"},{"key":"2416_CR85","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines14010228","volume":"14","author":"Y Wan","year":"2026","unstructured":"Wan Y, Jing M, Zhang L, Song Q, Ye X, Zhou Z et al (2026) The mechanism and regulation of disulfidptosis and its role in disease. Biomedicines 14:228","journal-title":"Biomedicines"},{"key":"2416_CR86","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-025-02447-x","volume":"23","author":"H Qiu","year":"2025","unstructured":"Qiu H, Liu J, Shao N, Zhao J, Chen C, Jiang Y et al (2025) SLC7A11 as a bridge between ferroptosis and disulfidptosis: a promising target for tumor treatment. Cell Commun Signal 23:460","journal-title":"Cell Commun Signal"},{"key":"2416_CR87","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.tcb.2023.07.009","volume":"34","author":"X Liu","year":"2024","unstructured":"Liu X, Zhuang L, Gan B (2024) Disulfidptosis: disulfide stress-induced cell death. Trends Cell Biol 34:327\u2013337","journal-title":"Trends Cell Biol"},{"key":"2416_CR88","doi-asserted-by":"publisher","DOI":"10.3390\/biom15050659","author":"D Lu","year":"2025","unstructured":"Lu D, Xia B, Feng T, Qi G, Ma Z (2025) The role of cancer organoids in ferroptosis, pyroptosis, and necroptosis: functions and clinical implications. Biomolecules. https:\/\/doi.org\/10.3390\/biom15050659","journal-title":"Biomolecules"},{"key":"2416_CR89","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-025-02529-x","volume":"25","author":"X-X Huang","year":"2025","unstructured":"Huang X-X, Xie C-K, Mo Y-C, Li W, Wu Y-D, Li Z-Y et al (2025) Targeting SERPINB3\u2013MAPK axis-mediated cuproptosis resistance enhances the response to antitumor immunotherapy. Mol Cancer 25:47","journal-title":"Mol Cancer"},{"key":"2416_CR90","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.cmet.2024.10.006","volume":"37","author":"X Zha","year":"2025","unstructured":"Zha X, Liu X, Wei M, Huang H, Cao J, Liu S et al (2025) Microbiota-derived lysophosphatidylcholine alleviates Alzheimer\u2019s disease pathology via suppressing ferroptosis. Cell Metab 37:169\u201386.e9","journal-title":"Cell Metab"},{"key":"2416_CR91","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.nbd.2016.05.011","volume":"94","author":"B Do Van","year":"2016","unstructured":"Do Van B, Gouel F, Jonneaux A, Timmerman K, Gel\u00e9 P, P\u00e9trault M et al (2016) Ferroptosis, a newly characterized form of cell death in Parkinson\u2019s disease that is regulated by PKC. Neurobiol Dis 94:169\u2013178","journal-title":"Neurobiol Dis"},{"key":"2416_CR92","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.clnu.2025.03.023","volume":"48","author":"Y Fu","year":"2025","unstructured":"Fu Y, Hou L, Han K, Zhao C, Hu H, Yin S (2025) The physiological role of copper: dietary sources, metabolic regulation, and safety concerns. Clin Nutr 48:161\u2013179","journal-title":"Clin Nutr"},{"key":"2416_CR93","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1097\/CM9.0000000000002909","volume":"137","author":"M Zeng","year":"2024","unstructured":"Zeng M, Wu B, Wei W, Jiang Z, Li P, Quan Y et al (2024) Disulfiram: a novel repurposed drug for cancer therapy. Chin Med J (Engl) 137:1389\u20131398","journal-title":"Chin Med J (Engl)"},{"key":"2416_CR94","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-026-01686-w","author":"D Tang","year":"2026","unstructured":"Tang D, Melino G, Kroemer G (2026) Beyond the canon: emerging modalities of regulated cell death. Cell Death Differ. https:\/\/doi.org\/10.1038\/s41418-026-01686-w","journal-title":"Cell Death Differ"},{"key":"2416_CR95","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/s41590-017-0013-y","volume":"19","author":"C Holze","year":"2018","unstructured":"Holze C, Michaudel C, Mackowiak C, Haas DA, Benda C, Hubel P et al (2018) Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway. Nat Immunol 19:130\u2013140","journal-title":"Nat Immunol"},{"key":"2416_CR96","doi-asserted-by":"publisher","first-page":"6434","DOI":"10.1038\/onc.2008.310","volume":"27","author":"P Boya","year":"2008","unstructured":"Boya P, Kroemer G (2008) Lysosomal membrane permeabilization in cell death. Oncogene 27:6434\u20136451","journal-title":"Oncogene"},{"key":"2416_CR97","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1111\/tra.12613","volume":"19","author":"F Wang","year":"2018","unstructured":"Wang F, G\u00f3mez-Sintes R, Boya P (2018) Lysosomal membrane permeabilization and cell death. Traffic 19:918\u2013931","journal-title":"Traffic"},{"key":"2416_CR98","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202515904","volume":"38","author":"Y Xie","year":"2026","unstructured":"Xie Y, Wang J, Han Y, Zhu G, Li L, Sun Q et al (2026) Antagonistic iron competition induced by iron chelators heightens cuproptosis in both tumors and intratumoral bacteria. Adv Mater 38:e15904","journal-title":"Adv Mater"},{"key":"2416_CR99","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/s41580-025-00843-2","volume":"26","author":"E Mishima","year":"2025","unstructured":"Mishima E, Nakamura T, Doll S, Proneth B, Fedorova M, Pratt DA et al (2025) Recommendations for robust and reproducible research on ferroptosis. Nat Rev Mol Cell Biol 26:615\u2013630","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2416_CR100","doi-asserted-by":"publisher","first-page":"13183","DOI":"10.2147\/IJN.S558103","volume":"20","author":"Y Luo","year":"2025","unstructured":"Luo Y, Lin X, Su C, Zheng Z, Li Y, Guo W et al (2025) Nanomaterial-driven regulated cell death: mechanistic insights and novel strategies for tumor therapy. Int J Nanomed 20:13183\u201313208","journal-title":"Int J Nanomed"},{"key":"2416_CR101","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-14811-8","volume":"25","author":"P Nikeghbal","year":"2025","unstructured":"Nikeghbal P, Zamanian D, Burke D, Steinkamp MP (2025) Organoid models established from primary tumors and patient-derived xenograft tumors reflect platinum sensitivity of ovarian cancer patients. BMC Cancer 25:1459","journal-title":"BMC Cancer"},{"key":"2416_CR102","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.115788","volume":"168","author":"X Chen","year":"2026","unstructured":"Chen X, Huang L, Liu R, Nan D, Li Y, Chen W et al (2026) Cuproptosis as a regulator in human diseases: from basic mechanisms to clinical relevance. Int Immunopharmacol 168:115788","journal-title":"Int Immunopharmacol"},{"key":"2416_CR103","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.149257","volume":"335","author":"A Sharma","year":"2026","unstructured":"Sharma A, Srivastava Y, Prasad S, Ghosh S, Kumar RS, Bharti AC et al (2026) SLC7A11 as a molecular nexus of prognosis, resistance, and therapeutic roadmap in cancer: a systematic review and meta-analysis. Int J Biol Macromol 335:149257","journal-title":"Int J Biol Macromol"},{"key":"2416_CR104","unstructured":"Rubedo Life Sciences (2025) Rubedo Life Sciences Announces U.S. FDA Clearance of IND for Selective GPX4 Modulating Lead Drug Candidate RLS-1496 for Actinic Keratosis, Expands Clinical Advisory Board. Business Wire, 17 September 2025"},{"key":"2416_CR105","doi-asserted-by":"publisher","first-page":"6160","DOI":"10.1016\/j.ymthe.2025.09.004","volume":"33","author":"Q Yu","year":"2025","unstructured":"Yu Q, Jiang K, Ma S, Zheng Q, Tondi S, Reina C et al (2025) Elesclomol-copper combination synergistically targets mitochondrial metabolism in cancer stem cells to overcome chemoresistance in PDAC. Mol Ther 33:6160\u20136177","journal-title":"Mol Ther"},{"key":"2416_CR106","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202503530","volume":"15","author":"K Deng","year":"2026","unstructured":"Deng K, Gao W, Wen Y, Huang J, Li X, Yang X et al (2026) A functional nanocomposite tri-activates cuproptosis, ferroptosis, and mitophagy death pathway to oppose malignancies. Adv Healthc Mater 15:e03530","journal-title":"Adv Healthc Mater"},{"key":"2416_CR107","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-025-01722-1","volume":"18","author":"X Cheng","year":"2025","unstructured":"Cheng X, Peng T, Chu T, Yang Y, Liu J, Gao Q et al (2025) Application of single-cell and spatial omics in deciphering cellular hallmarks of cancer drug response and resistance. J Hematol Oncol 18:70","journal-title":"J Hematol Oncol"},{"key":"2416_CR108","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1186\/s12967-025-07596-8","volume":"24","author":"DA Malik","year":"2026","unstructured":"Malik DA, Schmieder EAS, Genova G, Gaskins J, Martin Ii RCG (2026) Organoids in translation: a bench-to-bedside framework for pancreatic cancer precision medicine. J Transl Med 24:136","journal-title":"J Transl Med"},{"key":"2416_CR109","doi-asserted-by":"publisher","first-page":"4485","DOI":"10.7150\/ijbs.114373","volume":"21","author":"S Liu","year":"2025","unstructured":"Liu S, Zhang R, Liu Y, Lin X, Chen J (2025) Cancer patient-derived organoids: novel models for the study of natural products. Int J Biol Sci 21:4485\u20134503","journal-title":"Int J Biol Sci"},{"key":"2416_CR110","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.20686","volume":"14","author":"HP Lu","year":"2026","unstructured":"Lu HP, Nong K, Pang L, Tang Y, Li Q, Chen Z et al (2026) Epigenetic activation of SLC7A11 defines a ferroptosis-immune axis and enables robust DNA methylation-based diagnosis of lung squamous cell carcinoma. PeerJ 14:e20686","journal-title":"PeerJ"},{"key":"2416_CR111","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s43556-025-00347-7","volume":"6","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, Gu Y, Zhan M, Yang L, Wang H (2025) Targeting ferroptosis and cuproptosis in gastrointestinal cancers: molecular mechanisms, metabolic vulnerabilities, and therapeutic interventions. Mol Biomed 6:101","journal-title":"Mol Biomed"},{"key":"2416_CR112","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.cell.2019.04.024","volume":"177","author":"DR Green","year":"2019","unstructured":"Green DR (2019) The coming decade of cell death research: five riddles. Cell 177:1094\u20131107","journal-title":"Cell"},{"key":"2416_CR113","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/cdd.2008.150","volume":"16","author":"G Kroemer","year":"2009","unstructured":"Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH et al (2009) Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ 16:3\u201311","journal-title":"Cell Death Differ"},{"key":"2416_CR114","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","volume":"12","author":"D Hanahan","year":"2022","unstructured":"Hanahan D (2022) Hallmarks of cancer: new dimensions. Cancer Discov 12:31\u201346","journal-title":"Cancer Discov"},{"key":"2416_CR115","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1685331","volume":"16","author":"X Li","year":"2025","unstructured":"Li X, Gao Y, Xing Z, Liu Z, Zhang X (2025) Iron, copper and disulfide dysregulation: molecular crossroads of metabolic cell death in melanoma progression. Front Pharmacol 16:1685331","journal-title":"Front Pharmacol"},{"key":"2416_CR116","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-01977-1","volume":"23","author":"S Yang","year":"2024","unstructured":"Yang S, Hu C, Chen X, Tang Y, Li J, Yang H et al (2024) Crosstalk between metabolism and cell death in tumorigenesis. Mol Cancer 23:71","journal-title":"Mol Cancer"},{"key":"2416_CR117","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202500010","volume":"358","author":"L Zhang","year":"2025","unstructured":"Zhang L, Li Y, Qian Y, Xie R, Peng W, Zhou W (2025) Advances in the development of ferroptosis-inducing agents for cancer treatment. Arch Pharm 358:e202500010","journal-title":"Arch Pharm"},{"key":"2416_CR118","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/s41698-025-00994-7","volume":"9","author":"C Liu","year":"2025","unstructured":"Liu C, Wang S, Zhao J, Qiu H, Du H (2025) Modulating ovarian cancer progression through FDX1-driven autophagy. NPJ Precis Oncol 9:230","journal-title":"NPJ Precis Oncol"},{"key":"2416_CR119","doi-asserted-by":"publisher","first-page":"917","DOI":"10.14336\/AD.2024.0083","volume":"16","author":"Q Gu","year":"2024","unstructured":"Gu Q, An Y, Xu M, Huang X, Chen X, Li X et al (2024) Disulfidptosis, a novel cell death pathway: molecular landscape and therapeutic implications. Aging Dis 16:917\u2013945","journal-title":"Aging Dis"},{"key":"2416_CR120","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117710","volume":"293","author":"X Yang","year":"2025","unstructured":"Yang X, Wang L, Lin P, Ning Y, Lin Y, Xie Y et al (2025) Discovery of artesunate (ARS) PROTACs as GPX4 protein degraders for the treatment of bladder cancer. Eur J Med Chem 293:117710","journal-title":"Eur J Med Chem"},{"key":"2416_CR121","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202401646","volume":"13","author":"N Wang","year":"2024","unstructured":"Wang N, Liu Y, Peng D, Zhang Q, Zhang Z, Xu L et al (2024) Copper-based composites nanoparticles improve triple-negative breast cancer treatment with induction of apoptosis-cuproptosis and immune activation. Adv Healthc Mater 13:e2401646","journal-title":"Adv Healthc Mater"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-026-02416-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-026-02416-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-026-02416-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:02:54Z","timestamp":1787162574000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-026-02416-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":121,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["2416"],"URL":"https:\/\/doi.org\/10.1007\/s10495-026-02416-w","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"12 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"205"}}