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Written informed consent was obtained from all participants or their legal guardians prior to sample collection. All human data were anonymized before analysis. All animal experiments were approved by the Ethics Committee of the Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Soochow University (Approval No. 2023-CL022) and were conducted in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and ARRIVE guidelines. All procedures involving animals were performed in compliance with relevant institutional and national regulations.","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"211"}}