{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:47:36Z","timestamp":1791802056426,"version":"4.3.4"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the National Natural Science Foundation of China","award":["82570479"],"award-info":[{"award-number":["82570479"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Science and Technology Projects of Xizang Autonomous Region","award":["XZ202501ZY0044"],"award-info":[{"award-number":["XZ202501ZY0044"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Apoptosis"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s10495-026-02455-3","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:09:55Z","timestamp":1791050995000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anastasis: an unwelcome guest in cancer therapy"],"prefix":"10.1007","volume":"31","author":[{"given":"Yizhi","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7623-7109","authenticated-orcid":false,"given":"Yuyan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,3]]},"reference":[{"key":"2455_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s004419900160","volume":"301","author":"G Makin","year":"2000","unstructured":"Makin G, Hickman J (2000) Apoptosis and cancer chemotherapy. Cell Tissue Res 301:143\u2013152. https:\/\/doi.org\/10.1007\/s004419900160","journal-title":"Cell Tissue Res"},{"key":"2455_CR2","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","volume":"35","author":"S Elmore","year":"2007","unstructured":"Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35:495\u2013516. https:\/\/doi.org\/10.1080\/01926230701320337","journal-title":"Toxicol Pathol"},{"key":"2455_CR3","doi-asserted-by":"publisher","unstructured":"Tang HM, Tang HL (2018) Anastasis: recovery from the brink of cell death. Royal Soc open Sci 5. https:\/\/doi.org\/10.1098\/rsos.180442","DOI":"10.1098\/rsos.180442"},{"key":"2455_CR4","doi-asserted-by":"publisher","first-page":"3355","DOI":"10.1083\/jcb.201706134","volume":"216","author":"G Sun","year":"2017","unstructured":"Sun G, Guzman E, Balasanyan V, Conner CM, Wong K, Zhou HR, Kosik KS, Montell DJ (2017) A molecular signature for anastasis, recovery from the brink of apoptotic cell death. J Cell Biol 216:3355\u20133368. https:\/\/doi.org\/10.1083\/jcb.201706134","journal-title":"J Cell Biol"},{"key":"2455_CR5","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1091\/mbc.e11-11-0926","volume":"23","author":"HL Tang","year":"2012","unstructured":"Tang HL, Tang HM, Mak KH, Hu S, Wang SS, Wong KM, Wong CST, Wu HY, Law HT, Liu K (2012) Cell survival, DNA damage, and oncogenic transformation after a transient and reversible apoptotic response. Mol Biol Cell 23:2240\u20132252. https:\/\/doi.org\/10.1091\/mbc.e11-11-0926","journal-title":"Mol Biol Cell"},{"key":"2455_CR6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12964-022-00880-w","volume":"20","author":"RN Mohammed","year":"2022","unstructured":"Mohammed RN, Khosravi M, Rahman HS, Adili A, Kamali N, Soloshenkov PP, Thangavelu L, Saeedi H, Shomali N, Tamjidifar R (2022) Anastasis: cell recovery mechanisms and potential role in cancer. Cell Communication Signal 20:81. https:\/\/doi.org\/10.1186\/s12964-022-00880-w","journal-title":"Cell Commun Signal"},{"key":"2455_CR7","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/s41419-023-05916-8","volume":"14","author":"R Wang","year":"2023","unstructured":"Wang R, Wang Y, Liu X, Liu M, Sun L, Pan X, Hu H, Jiang B, Zou Y, Liu Q (2023) Anastasis enhances metastasis and chemoresistance of colorectal cancer cells through upregulating cIAP2\/NF\u03baB signaling. Cell Death Dis 14:388. https:\/\/doi.org\/10.1038\/s41419-023-05916-8","journal-title":"Cell Death Dis"},{"key":"2455_CR8","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.neo.2018.01.005","volume":"20","author":"Y Xu","year":"2018","unstructured":"Xu Y, So C, Lam H-M, Fung M-C, Tsang S-Y (2018) Apoptosis reversal promotes cancer stem cell-like cell formation. Neoplasia 20:295\u2013303. https:\/\/doi.org\/10.1016\/j.neo.2018.01.005","journal-title":"Neoplasia"},{"key":"2455_CR9","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1038\/s41418-022-01081-1","volume":"30","author":"L Sun","year":"2023","unstructured":"Sun L, Yao C, Li X, Wang Y, Wang R, Wang M, Liu Q, Montell DJ, Shao C, Gong Y (2023) Anastasis confers ovarian cancer cells increased malignancy through elevated p38 MAPK activation. Cell Death Differ 30:809\u2013824. https:\/\/doi.org\/10.1038\/s41418-022-01081-1","journal-title":"Cell Death Differ"},{"key":"2455_CR10","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/s41389-023-00479-x","volume":"12","author":"Y Wang","year":"2023","unstructured":"Wang Y, Wang R, Liu X, Liu M, Sun L, Pan X, Hu H, Jiang B, Zou Y, Liu Q (2023) Chemotherapy-induced executioner caspase activation increases breast cancer malignancy through epigenetic de-repression of CDH12. Oncogenesis 12:34. https:\/\/doi.org\/10.1038\/s41389-023-00479-x","journal-title":"Oncogenesis"},{"key":"2455_CR11","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s13402-019-00451-1","volume":"42","author":"M Seervi","year":"2019","unstructured":"Seervi M, Sumi S, Chandrasekharan A, Sharma AK, SanthoshKumar T (2019) Molecular profiling of anastatic cancer cells: potential role of the nuclear export pathway. Cell Oncol 42:645\u2013661. https:\/\/doi.org\/10.1007\/s13402-019-00451-1","journal-title":"Cell Oncol"},{"key":"2455_CR12","doi-asserted-by":"publisher","unstructured":"Tang HM, Talbot CC Jr, Fung MC, Tang HL (2017) Molecular signature of anastasis for reversal of apoptosis. https:\/\/doi.org\/10.12688\/f1000research.10568.2. F1000Research 6:43","DOI":"10.12688\/f1000research.10568.2"},{"key":"2455_CR13","doi-asserted-by":"publisher","unstructured":"Tang HM, Tang HL (2025) Unravelling the pathological roles of anastasis in cancer recurrence. Open Biology 15. https:\/\/doi.org\/10.1098\/rsob.240270","DOI":"10.1098\/rsob.240270"},{"key":"2455_CR14","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s12915-017-0441-z","volume":"15","author":"G Sun","year":"2017","unstructured":"Sun G, Montell DJ (2017) Q&A: Cellular near death experiences\u2014what is anastasis? BMC Biol 15:92. https:\/\/doi.org\/10.1186\/s12915-017-0441-z","journal-title":"BMC Biol"},{"key":"2455_CR15","doi-asserted-by":"publisher","unstructured":"Tang HM, Fung MC, Tang HL (2018) Detecting anastasis in vivo by CaspaseTracker biosensor. J visualized experiments JoVE 54107. https:\/\/doi.org\/10.3791\/54107","DOI":"10.3791\/54107"},{"key":"2455_CR16","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.molcel.2015.01.018","volume":"57","author":"G Ichim","year":"2015","unstructured":"Ichim G, Lopez J, Ahmed SU, Muthalagu N, Giampazolias E, Delgado ME, Haller M, Riley JS, Mason SM, Athineos D (2015) Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death. Mol Cell 57:860\u2013872. https:\/\/doi.org\/10.1016\/j.molcel.2015.01.018","journal-title":"Mol Cell"},{"key":"2455_CR17","doi-asserted-by":"publisher","first-page":"6144","DOI":"10.3390\/ijms22116144","volume":"22","author":"CJ Hawkins","year":"2021","unstructured":"Hawkins CJ, Miles MA (2021) Mutagenic consequences of sublethal cell death signaling. Int J Mol Sci 22:6144. https:\/\/doi.org\/10.3390\/ijms22116144","journal-title":"Int J Mol Sci"},{"key":"2455_CR18","doi-asserted-by":"publisher","unstructured":"Berthenet K, Ferrer CC, Fanfone D, Popgeorgiev N, Neves D, Bertolino P, Gibert B, Hernandez-Vargas H, Ichim G (2020) Failed apoptosis enhances melanoma cancer cell aggressiveness. Cell Rep 31. https:\/\/doi.org\/10.1016\/j.celrep.2020.107731","DOI":"10.1016\/j.celrep.2020.107731"},{"key":"2455_CR19","doi-asserted-by":"publisher","first-page":"e2216531120","DOI":"10.1073\/pnas.2216531120","volume":"120","author":"M Nano","year":"2023","unstructured":"Nano M, Mondo JA, Harwood J, Balasanyan V, Montell DJ (2023) Cell survival following direct executioner-caspase activation. Proc Natl Acad Sci 120:e2216531120. https:\/\/doi.org\/10.1073\/pnas.2216531120","journal-title":"Proc Natl Acad Sci"},{"key":"2455_CR20","doi-asserted-by":"crossref","unstructured":"James D, Parone PA, Terradillos O et al (2007) Mechanisms of mitochondrial outer membrane permeabilization. In: Mitochondrial biology: new perspectives: Novartis Foundation Symposium 287. John Wiley & Sons, Ltd, Chichester, UK, pp 170\u2013182","DOI":"10.1002\/9780470725207.ch12"},{"key":"2455_CR21","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/s0092-8674(00)00008-8","volume":"102","author":"C Du","year":"2000","unstructured":"Du C, Fang M, Li Y, Li L, Wang X (2000) Smac, a mitochondrial protein that promotes cytochrome c\u2013dependent caspase activation by eliminating IAP inhibition. Cell 102:33\u201342. https:\/\/doi.org\/10.1016\/s0092-8674(00)00008-8","journal-title":"Cell"},{"key":"2455_CR22","doi-asserted-by":"publisher","first-page":"6669","DOI":"10.1038\/sj.onc.1206794","volume":"22","author":"S Gurbuxani","year":"2003","unstructured":"Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G (2003) Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene 22:6669\u20136678. https:\/\/doi.org\/10.1038\/sj.onc.1206794","journal-title":"Oncogene"},{"key":"2455_CR23","doi-asserted-by":"publisher","first-page":"3671","DOI":"10.3390\/cancers13153671","volume":"13","author":"V Zaitceva","year":"2021","unstructured":"Zaitceva V, Kopeina GS, Zhivotovsky B (2021) Anastasis: return journey from cell death. Cancers 13:3671. https:\/\/doi.org\/10.3390\/cancers13153671","journal-title":"Cancers"},{"key":"2455_CR24","doi-asserted-by":"publisher","first-page":"105894","DOI":"10.1016\/j.tiv.2024.105894","volume":"100","author":"GG Eskiler","year":"2024","unstructured":"Eskiler GG, Ozkan AD, Elmas MA, Ozturk M, Arbak S (2024) The recovery from taxane mediated apoptosis in PC-3 castration-resistant metastatic prostate cancer cells. Toxicol In Vitro 100:105894. https:\/\/doi.org\/10.1016\/j.tiv.2024.105894","journal-title":"Toxicol In Vitro"},{"key":"2455_CR25","doi-asserted-by":"publisher","first-page":"14","DOI":"10.30621\/jbachs.854986","volume":"5","author":"M Inceboz","year":"2021","unstructured":"Inceboz M, Bagca BG, Caner A, G\u00fcnd\u00fcz C (2021) Anastasis in glioblastoma, brain cancer stem, and brain stem cells. J Basic Clin Health Sci 5:14\u201321. https:\/\/doi.org\/10.30621\/jbachs.854986","journal-title":"J Basic Clin Health Sci"},{"key":"2455_CR26","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/s41419-020-2654-2","volume":"11","author":"V Pandya","year":"2020","unstructured":"Pandya V, Githaka JM, Patel N, Veldhoen R, Hugh J, Damaraju S, McMullen T, Mackey J, Goping IS (2020) BIK drives an aggressive breast cancer phenotype through sublethal apoptosis and predicts poor prognosis of ER-positive breast cancer. Cell Death Dis 11:448. https:\/\/doi.org\/10.1038\/s41419-020-2654-2","journal-title":"Cell Death Dis"},{"key":"2455_CR27","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1002\/mco2.100","volume":"2","author":"M Liu","year":"2021","unstructured":"Liu M, Yang J, Xu B, Zhang X (2021) Tumor metastasis: mechanistic insights and therapeutic interventions. MedComm 2:587\u2013617. https:\/\/doi.org\/10.1002\/mco2.100","journal-title":"MedComm"},{"key":"2455_CR28","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s41392-023-01460-1","volume":"8","author":"Z-L Liu","year":"2023","unstructured":"Liu Z-L, Chen H-H, Zheng L-L, Sun L-P, Shi L (2023) Angiogenic signaling pathways and anti-angiogenic therapy for cancer. Signal Transduct Target therapy 8:198. https:\/\/doi.org\/10.1038\/s41392-023-01460-1","journal-title":"Signal Transduct Target therapy"},{"key":"2455_CR29","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.3390\/cancers12051172","volume":"12","author":"H Saman","year":"2020","unstructured":"Saman H, Raza SS, Uddin S, Rasul K (2020) Inducing angiogenesis, a key step in cancer vascularization, and treatment approaches. Cancers 12:1172. https:\/\/doi.org\/10.3390\/cancers12051172","journal-title":"Cancers"},{"key":"2455_CR30","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3233\/CH-121647","volume":"54","author":"B Li","year":"2013","unstructured":"Li B, Xiu R (2013) Angiogenesis: from molecular mechanisms to translational implications. Clin Hemorheol Microcirc 54:345\u2013355. https:\/\/doi.org\/10.3233\/CH-121647","journal-title":"Clin Hemorheol Microcirc"},{"key":"2455_CR31","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.canlet.2016.10.042","volume":"385","author":"X Feng","year":"2017","unstructured":"Feng X, Yu Y, He S, Cheng J, Gong Y, Zhang Z, Yang X, Xu B, Liu X, Li C-Y (2017) Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism. Cancer Lett 385:12\u201320. https:\/\/doi.org\/10.1016\/j.canlet.2016.10.042","journal-title":"Cancer Lett"},{"key":"2455_CR32","doi-asserted-by":"publisher","first-page":"5958","DOI":"10.1158\/0008-5472.CAN-19-0840","volume":"79","author":"A Bernard","year":"2019","unstructured":"Bernard A, Chevrier S, Beltjens F, Dosset M, Viltard E, Lagrange A, Derang\u00e8re V, Oudot A, Ghiringhelli F, Collin B (2019) Cleaved caspase-3 transcriptionally regulates angiogenesis-promoting chemotherapy resistance. Cancer Res 79:5958\u20135970. https:\/\/doi.org\/10.1158\/0008-5472.CAN-19-0840","journal-title":"Cancer Res"},{"key":"2455_CR33","doi-asserted-by":"publisher","unstructured":"Nano M, Montell DJ (eds) (2024) Apoptotic signaling: beyond cell death. Seminars Cell Dev Biol 156: 22\u201334. https:\/\/doi.org\/10.1016\/j.semcdb.2023.11.002","DOI":"10.1016\/j.semcdb.2023.11.002"},{"key":"2455_CR34","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/s41419-024-06939-5","volume":"15","author":"X An","year":"2024","unstructured":"An X, Yu W, Liu J, Tang D, Yang L, Chen X (2024) Oxidative cell death in cancer: mechanisms and therapeutic opportunities. Cell Death Dis 15:556. https:\/\/doi.org\/10.1038\/s41419-024-06939-5","journal-title":"Cell Death Dis"},{"key":"2455_CR35","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1038\/sj.cdd.4401963","volume":"13","author":"J Chipuk","year":"2006","unstructured":"Chipuk J, Bouchier-Hayes L, Green D (2006) Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death Differ 13:1396\u20131402. https:\/\/doi.org\/10.1038\/sj.cdd.4401963","journal-title":"Cell Death Differ"},{"key":"2455_CR36","doi-asserted-by":"publisher","unstructured":"Hashemi SR, Hosseinpour-Soleimani F, Abedi M, Tajbakhsh A, Nemati MM, Salmasi Z, Savardashtaki A, Irajie C (2025) Nanomedicine solutions for inhibiting anastasis and inducing apoptosis to mitigate relapse in treatment-resistant cancers. Eur J Pharmacol 178121. https:\/\/doi.org\/10.1016\/j.ejphar.2025.178121","DOI":"10.1016\/j.ejphar.2025.178121"},{"key":"2455_CR37","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s10555-020-09866-x","volume":"39","author":"S Chakraborty","year":"2020","unstructured":"Chakraborty S, Mir KB, Seligson ND, Nayak D, Kumar R, Goswami A (2020) Integration of EMT and cellular survival instincts in reprogramming of programmed cell death to anastasis. Cancer Metastasis Rev 39:553\u2013566. https:\/\/doi.org\/10.1007\/s10555-020-09866-x","journal-title":"Cancer Metastasis Rev"},{"key":"2455_CR38","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/s41580-020-0237-9","volume":"21","author":"J Yang","year":"2020","unstructured":"Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G (2020) Guidelines and definitions for research on epithelial\u2013mesenchymal transition. Nat Rev Mol Cell Biol 21:341\u2013352. https:\/\/doi.org\/10.1038\/s41580-020-0237-9","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2455_CR39","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/s43018-026-01154-x","volume":"7","author":"R Jimenez-Casta\u00f1o","year":"2026","unstructured":"Jimenez-Casta\u00f1o R, Nieto MA (2026) Epithelial-to-mesenchymal transition as a central driver of tumor cell plasticity. Nat Cancer 7:567\u2013582. https:\/\/doi.org\/10.1038\/s43018-026-01154-x","journal-title":"Nat Cancer"},{"key":"2455_CR40","doi-asserted-by":"publisher","first-page":"9077","DOI":"10.1007\/s13277-015-4555-z","volume":"37","author":"J Ma","year":"2016","unstructured":"Ma J, Zhao J, Lu J, Wang P, Feng H, Zong Y, Ou B, Zheng M, Lu A (2016) Cadherin-12 enhances proliferation in colorectal cancer cells and increases progression by promoting EMT. Tumor Biology 37:9077\u20139088. https:\/\/doi.org\/10.1007\/s13277-015-4555-z","journal-title":"Tumor Biology"},{"key":"2455_CR41","doi-asserted-by":"publisher","first-page":"16077","DOI":"10.1038\/srep16077","volume":"5","author":"AS Azmi","year":"2015","unstructured":"Azmi AS, Muqbil I, Wu J, Aboukameel A, Senapedis W, Baloglu E, Bollig-Fischer A, Dyson G, Kauffman M, Landesman Y (2015) Targeting the nuclear export protein XPO1\/CRM1 reverses epithelial to mesenchymal transition. Sci Rep 5:16077. https:\/\/doi.org\/10.1038\/srep16077","journal-title":"Sci Rep"},{"key":"2455_CR42","doi-asserted-by":"crossref","unstructured":"McDonald PC, Nagel JM, Dedhar S (2021) Anastasis, recovery from the brink of death as a mechanism of drug resistance. Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance. Elsevier, pp 251\u2013260","DOI":"10.1016\/B978-0-12-821310-0.00004-8"},{"key":"2455_CR43","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0092-8674(02)00625-6","volume":"108","author":"RW Johnstone","year":"2002","unstructured":"Johnstone RW, Ruefli AA, Lowe SW (2002) Apoptosis: a link between cancer genetics and chemotherapy. Cell 108:153\u2013164. https:\/\/doi.org\/10.1016\/S0092-8674(02)00625-6","journal-title":"Cell"},{"key":"2455_CR44","doi-asserted-by":"publisher","first-page":"4912","DOI":"10.1158\/0008-5472.CAN-04-0673","volume":"64","author":"KI Amiri","year":"2004","unstructured":"Amiri KI, Horton LW, LaFleur BJ, Sosman JA, Richmond A (2004) Augmenting chemosensitivity of malignant melanoma tumors via proteasome inhibition: implication for bortezomib (VELCADE, PS-341) as a therapeutic agent for malignant melanoma. Cancer Res 64:4912\u20134918. https:\/\/doi.org\/10.1158\/0008-5472.CAN-04-0673","journal-title":"Cancer Res"},{"key":"2455_CR45","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/carcin\/bgv006","volume":"36","author":"S Toden","year":"2015","unstructured":"Toden S, Okugawa Y, Jascur T, Wodarz D, Komarova NL, Buhrmann C, Shakibaei M, Boland CR, Goel A (2015) Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelial-to-mesenchymal transition in chemoresistant colorectal cancer. Carcinogenesis 36:355\u2013367. https:\/\/doi.org\/10.1093\/carcin\/bgv006","journal-title":"Carcinogenesis"},{"key":"2455_CR46","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1158\/1078-0432.CCR-05-1220","volume":"12","author":"J Yang","year":"2006","unstructured":"Yang J, Amiri KI, Burke JR, Schmid JA, Richmond A (2006) BMS-345541 targets inhibitor of \u03baB kinase and induces apoptosis in melanoma: involvement of nuclear factor \u03baB and mitochondria pathways. Clin Cancer Res 12:950\u2013960. https:\/\/doi.org\/10.1158\/1078-0432.CCR-05-1220","journal-title":"Clin Cancer Res"},{"key":"2455_CR47","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1007\/s10585-012-9473-5","volume":"29","author":"M Zollo","year":"2012","unstructured":"Zollo M, Di Dato V, Spano D, De Martino D, Liguori L, Marino N, Vastolo V, Navas L, Garrone B, Mangano G (2012) Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models. Clin Exp Metastasis 29:585\u2013601. https:\/\/doi.org\/10.1007\/s10585-012-9473-5","journal-title":"Clin Exp Metastasis"},{"key":"2455_CR48","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3389\/fonc.2013.00120","volume":"3","author":"P Godwin","year":"2013","unstructured":"Godwin P, Baird A-M, Heavey S, Barr M, O\u2019byrne K, Gately K (2013) Targeting nuclear factor-kappa B to overcome resistance to chemotherapy. Front Oncol 3:120. https:\/\/doi.org\/10.3389\/fonc.2013.00120","journal-title":"Front Oncol"},{"key":"2455_CR49","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s12885-015-1186-0","volume":"15","author":"M Broecker-Preuss","year":"2015","unstructured":"Broecker-Preuss M, M\u00fcller S, Britten M, Worm K, Schmid KW, Mann K, Fuhrer D (2015) Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or BRAF mutational status. BMC Cancer 15:184. https:\/\/doi.org\/10.1186\/s12885-015-1186-0","journal-title":"BMC Cancer"},{"key":"2455_CR50","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0928-0987(01)00139-7","volume":"14","author":"M Baran\u010d\u0131\u0301k","year":"2001","unstructured":"Baran\u010d\u0131\u0301k M, Boh\u00e1\u010dov\u00e1 V, Kva\u010dkajov\u00e1 J, Hudecov\u00e1 S, Kri\u017eanov\u00e1 Og, Breier A (2001) SB203580, a specific inhibitor of p38-MAPK pathway, is a new reversal agent of P-glycoprotein-mediated multidrug resistance. Eur J Pharm Sci 14:29\u201336. https:\/\/doi.org\/10.1016\/S0928-0987(01)00139-7","journal-title":"Eur J Pharm Sci"},{"key":"2455_CR51","doi-asserted-by":"publisher","first-page":"11466","DOI":"10.1021\/acsomega.1c00521","volume":"6","author":"L Zhao","year":"2021","unstructured":"Zhao L, Wang Y, Xu Y, Sun Q, Liu H, Chen Q, Liu B (2021) BIRB796, an inhibitor of p38 mitogen-activated protein kinase, inhibits proliferation and invasion in glioblastoma cells. ACS Omega 6:11466\u201311473. https:\/\/doi.org\/10.1021\/acsomega.1c00521","journal-title":"ACS Omega"},{"key":"2455_CR52","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.ccr.2006.08.027","volume":"10","author":"MF Van Delft","year":"2006","unstructured":"Van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE, Willis SN, Scott CL, Day CL, Cory S (2006) The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak\/Bax if Mcl-1 is neutralized. Cancer Cell 10:389\u2013399. https:\/\/doi.org\/10.1016\/j.ccr.2006.08.027","journal-title":"Cancer Cell"},{"key":"2455_CR53","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1007\/s10495-008-0300-z","volume":"14","author":"A Frenzel","year":"2009","unstructured":"Frenzel A, Grespi F, Chmelewskij W, Villunger A (2009) Bcl2 family proteins in carcinogenesis and the treatment of cancer. Apoptosis 14:584\u2013596. https:\/\/doi.org\/10.1007\/s10495-008-0300-z","journal-title":"Apoptosis"},{"key":"2455_CR54","doi-asserted-by":"publisher","first-page":"7640","DOI":"10.1158\/0008-5472.CAN-10-3947","volume":"71","author":"RM Greer","year":"2011","unstructured":"Greer RM, Peyton M, Larsen JE, Girard L, Xie Y, Gazdar AF, Harran P, Wang L, Brekken RA, Wang X (2011) SMAC Mimetic (JP1201) sensitizes non\u2013small cell lung cancers to multiple chemotherapy agents in an IAP-dependent but TNF-\u03b1\u2013independent manner. Cancer Res 71:7640\u20137648. https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-3947","journal-title":"Cancer Res"},{"key":"2455_CR55","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/nrc2889","volume":"10","author":"M Gyrd-Hansen","year":"2010","unstructured":"Gyrd-Hansen M, Meier P (2010) IAPs: from caspase inhibitors to modulators of NF-\u03baB, inflammation and cancer. Nat Rev Cancer 10:561\u2013574. https:\/\/doi.org\/10.1038\/nrc2889","journal-title":"Nat Rev Cancer"},{"key":"2455_CR56","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.pharmthera.2014.05.007","volume":"144","author":"L Bai","year":"2014","unstructured":"Bai L, Smith DC, Wang S (2014) Small-molecule SMAC mimetics as new cancer therapeutics. Pharmacol Ther 144:82\u201395. https:\/\/doi.org\/10.1016\/j.pharmthera.2014.05.007","journal-title":"Pharmacol Ther"},{"key":"2455_CR57","doi-asserted-by":"publisher","first-page":"9112","DOI":"10.1073\/pnas.96.16.9112","volume":"96","author":"N Kudo","year":"1999","unstructured":"Kudo N, Matsumori N, Taoka H, Fujiwara D, Schreiner EP, Wolff B, Yoshida M, Horinouchi S (1999) Leptomycin B inactivates CRM1\/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci 96:9112\u20139117. https:\/\/doi.org\/10.1073\/pnas.96.16.9112","journal-title":"Proc Natl Acad Sci"},{"key":"2455_CR58","doi-asserted-by":"publisher","first-page":"4301","DOI":"10.1158\/1078-0432.CCR-16-263","volume":"23","author":"JS Nair","year":"2017","unstructured":"Nair JS, Musi E, Schwartz GK (2017) Selinexor (KPT-330) induces tumor suppression through nuclear sequestration of I\u03baB and downregulation of survivin. Clin Cancer Res 23:4301\u20134311. https:\/\/doi.org\/10.1158\/1078-0432.CCR-16-263","journal-title":"Clin Cancer Res"},{"key":"2455_CR59","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1182\/blood.V112.11.602.602","volume":"112","author":"EC Lopes","year":"2008","unstructured":"Lopes EC, Cerchietti L, Yang SN, Melnick A, Chiosis G (2008) Antitumor efficacy of the purine-scaffold Hsp90 inhibitor PU-H71 in diffuse large-B cell lymphoma. Blood 112:602. https:\/\/doi.org\/10.1182\/blood.V112.11.602.602","journal-title":"Blood"},{"key":"2455_CR60","doi-asserted-by":"publisher","first-page":"8368","DOI":"10.1073\/pnas.0903392106","volume":"106","author":"E Caldas-Lopes","year":"2009","unstructured":"Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, Moulick K, Taldone T, Gozman A, Guo Y (2009) Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc Natl Acad Sci 106:8368\u20138373. https:\/\/doi.org\/10.1073\/pnas.0903392106","journal-title":"Proc Natl Acad Sci"},{"key":"2455_CR61","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1038\/nm.2059","volume":"15","author":"LC Cerchietti","year":"2009","unstructured":"Cerchietti LC, Lopes EC, Yang SN, Hatzi K, Bunting KL, Tsikitas LA, Mallik A, Robles AI, Walling J, Varticovski L (2009) A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6\u2013dependent B cell lymphomas. Nat Med 15:1369\u20131376. https:\/\/doi.org\/10.1038\/nm.2059","journal-title":"Nat Med"},{"key":"2455_CR62","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.molonc.2013.12.005","volume":"8","author":"SR Ambati","year":"2014","unstructured":"Ambati SR, Lopes EC, Kosugi K, Mony U, Zehir A, Shah SK, Taldone T, Moreira AL, Meyers PA, Chiosis G (2014) Pre-clinical efficacy of PU\u2010H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma. Mol Oncol 8:323\u2013336. https:\/\/doi.org\/10.1016\/j.molonc.2013.12.005","journal-title":"Mol Oncol"},{"key":"2455_CR63","doi-asserted-by":"publisher","first-page":"9015","DOI":"10.1038\/srep09015","volume":"5","author":"HL Tang","year":"2015","unstructured":"Tang HL, Tang HM, Fung MC, Hardwick JM (2015) In vivo caspasetracker biosensor system for detecting anastasis and non-apoptotic caspase activity. Sci Rep 5:9015. https:\/\/doi.org\/10.1038\/srep09015","journal-title":"Sci Rep"},{"key":"2455_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10495-024-01990-1","volume":"30","author":"MH Vasileva","year":"2025","unstructured":"Vasileva MH, Bennemann A, Zachmann K, Sch\u00f6n MP, Frank J, Ulaganathan VK (2025) CD24 flags anastasis in melanoma cells. Apoptosis 30:1\u201315. https:\/\/doi.org\/10.1007\/s10495-024-01990-1","journal-title":"Apoptosis"},{"key":"2455_CR65","doi-asserted-by":"publisher","unstructured":"Tang HL, Tang HM, Hardwick JM, Fung MC (2015) Strategies for tracking anastasis, a cell survival phenomenon that reverses apoptosis. J Visual Exp JoVE 51964. https:\/\/doi.org\/10.3791\/51964","DOI":"10.3791\/51964"}],"container-title":["Apoptosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-026-02455-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10495-026-02455-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10495-026-02455-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:12:04Z","timestamp":1791799924000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10495-026-02455-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":65,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["2455"],"URL":"https:\/\/doi.org\/10.1007\/s10495-026-02455-3","relation":{},"ISSN":["1360-8185","1573-675X"],"issn-type":[{"value":"1360-8185","type":"print"},{"value":"1573-675X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"4 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors agreed to publish this article.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No applicable.","order":3,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"During the preparation of this work, the authors used GPT-5.5 solely for improving the clarity and grammatical accuracy of the language. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.","order":4,"name":"Ethics","label":"Declaration of Generative AI and AI-assisted technologies in the writing process","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"242"}}