{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:02:46Z","timestamp":1790928166608,"version":"4.1.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bull Exp Biol Med"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s10517-023-05713-5","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T09:52:13Z","timestamp":1675245133000},"page":"385-390","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Morphofunctional Changes in the Thymus in Prepubertal Male Wistar Rats in LPS-Induced Systemic Inflammatory Response in Relation to Hypoxia Tolerance"],"prefix":"10.1007","volume":"174","author":[{"given":"D. Sh.","family":"Dzhalilova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Kosyreva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. S.","family":"Tsvetkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. A.","family":"Zolotova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. V.","family":"Sentyabreva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. V.","family":"Makarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"issue":"3","key":"5713_CR1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.micinf.2016.11.003","volume":"19","author":"G Devraj","year":"2017","unstructured":"Devraj G, Beerlage C, Br\u00fcne B, Kempf VA. Hypoxia and HIF-1 activation in bacterial infections. Microbes Infect. 2017;19(3):144-156. https:\/\/doi.org\/10.1016\/j.micinf.2016.11.003","journal-title":"Microbes Infect."},{"issue":"2","key":"5713_CR2","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3390\/biomedicines6020056","volume":"6","author":"E Krzywinska","year":"2018","unstructured":"Krzywinska E, Stockmann C. Hypoxia, metabolism and immune cell function. Biomedicines. 2018;6(2):56. https:\/\/doi.org\/10.3390\/biomedicines6020056","journal-title":"Biomedicines."},{"key":"5713_CR3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.2147\/JIR.S194581","volume":"12","author":"DS Dzhalilova","year":"2019","unstructured":"Dzhalilova DS, Kosyreva AM, Diatroptov ME, Ponomarenko EA, Tsvetkov IS, Zolotova NA, Mkhitarov VA, Khochanskiy DN, Makarova OV. Dependence of the severity of the systemic inflammatory response on resistance to hypoxia in male Wistar rats. J. Inflamm. Res. 2019;12:73-86. https:\/\/doi.org\/10.2147\/JIR.S194581","journal-title":"J. Inflamm. Res."},{"issue":"6","key":"5713_CR4","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1134\/S0362119714060061","volume":"40","author":"SG Krivoshchekov","year":"2014","unstructured":"Krivoshchekov SG, Balioz NV, Nekipelova NV, Kapilevich LV. Age, gender, and individually-typological features of reaction to sharp hypoxic influence. Hum. Physiol. 2014;40(6):613-622.","journal-title":"Hum. Physiol."},{"issue":"1","key":"5713_CR5","doi-asserted-by":"publisher","first-page":"15884","DOI":"10.1038\/s41598-020-72537-y","volume":"10","author":"AM Kosyreva","year":"2020","unstructured":"Kosyreva AM, Dzhalilova DS, Makarova OV, Tsvetkov IS, Zolotova NA, Diatroptova MA, Ponomarenko EA, Mkhitarov VA, Khochanskiy DN, Mikhailova LP. Sex differences of inflammatory and immune response in pups of Wistar rats with SIRS. Sci. Rep. 2020;10(1):15884. https:\/\/doi.org\/10.1038\/s41598-020-72537-y","journal-title":"Sci. Rep."},{"key":"5713_CR6","unstructured":"Kosyreva AM, Makarova OV, Osmolovskaya E Yu. Age and sex-related differences in thymic morphological and functional changes in Wistar rats with systemic inflammatory response syndrome. Klin. Eksper. Morfol. 2016;(1):18-26. Russian."},{"key":"5713_CR7","doi-asserted-by":"publisher","unstructured":"Dzhalilova D, Kosyreva A, Vishnyakova P, Zolotova N, Tsvetkov I, Mkhitarov V, Mikhailova L, Kakturskiy L, Makarova O. Age-related differences in hypoxia-associated genes and cytokine profile in male Wistar rats. Heliyon. 2021;7(9):e08085. https:\/\/doi.org\/10.1016\/j.heliyon.2021.e08085","DOI":"10.1016\/j.heliyon.2021.e08085"},{"key":"5713_CR8","unstructured":"Pisarev VB, Bogomolova NV, Novochadov VV. Bacterial Endotoxication: Pathologist\u2019s View-Point. Volgograd, 2008."},{"issue":"6","key":"5713_CR9","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s00005-015-0348-8","volume":"63","author":"B Adamik","year":"2015","unstructured":"Adamik B, Zielinski S, Smiechowicz J, K\u00fcbler A. Endotoxin elimination in patients with septic shock: an observation study. Arch. Immunol. Ther. Exp. (Warsz). 2015;63(6):475-483. https:\/\/doi.org\/10.1007\/s00005-015-0348-8","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)"},{"issue":"1","key":"5713_CR10","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","volume":"5","author":"H Yu","year":"2020","unstructured":"Yu H, Lin L, Zhang Z, Zhang H, Hu H. Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct. Target. Ther. 2020;5(1):209. https:\/\/doi.org\/10.1038\/s41392-020-00312-6","journal-title":"Signal Transduct. Target. Ther."},{"issue":"3","key":"5713_CR11","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1182\/blood-2003-07-2427","volume":"103","author":"CC Blouin","year":"2004","unstructured":"Blouin CC, Pag\u00e9 EL, Soucy GM, Richard DE. Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1alpha. Blood. 2004;103(3):1124-1130. https:\/\/doi.org\/10.1182\/blood-2003-07-2427","journal-title":"Blood."},{"issue":"8","key":"5713_CR12","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1172\/JCI21086","volume":"114","author":"J Karhausen","year":"2004","unstructured":"Karhausen J, Furuta GT, Tomaszewski JE, Johnson RS, Colgan SP, Haase VH. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J. Clin. Invest. 2004;114(8):1098-1106. https:\/\/doi.org\/10.1172\/JCI21086","journal-title":"J. Clin. Invest."},{"issue":"12","key":"5713_CR13","doi-asserted-by":"publisher","first-page":"7516","DOI":"10.4049\/jimmunol.178.12.7516","volume":"178","author":"C Peyssonnaux","year":"2007","unstructured":"Peyssonnaux C, Cejudo-Martin P, Doedens A, Zinkernagel AS, Johnson RS, Nizet V. Cutting edge: essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. J. Immunol. 2007;178(12):7516-7519. https:\/\/doi.org\/10.4049\/jimmunol.178.12.7516","journal-title":"J. Immunol."},{"issue":"14","key":"5713_CR14","doi-asserted-by":"publisher","first-page":"2100543","DOI":"10.1002\/advs.202100543","volume":"8","author":"H Sharma","year":"2021","unstructured":"Sharma H, Moroni L. Recent advancements in regenerative approaches for thymus rejuvenation. Adv. Sci. (Weinh). 2021;8(14):2100543. https:\/\/doi.org\/10.1002\/advs.202100543","journal-title":"Adv. Sci. (Weinh)"},{"key":"5713_CR15","doi-asserted-by":"publisher","first-page":"547","DOI":"10.3389\/fimmu.2018.00547","volume":"9","author":"B Min","year":"2018","unstructured":"Min B. Spontaneous T cell proliferation: a physiologic process to create and maintain homeostatic balance and diversity of the immune system. Front. Immunol. 2018;9:547. https:\/\/doi.org\/10.3389\/fimmu.2018.00547","journal-title":"Front. Immunol."}],"container-title":["Bulletin of Experimental Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-023-05713-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10517-023-05713-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-023-05713-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T15:11:34Z","timestamp":1680793894000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10517-023-05713-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["5713"],"URL":"https:\/\/doi.org\/10.1007\/s10517-023-05713-5","relation":{},"ISSN":["0007-4888","1573-8221"],"issn-type":[{"value":"0007-4888","type":"print"},{"value":"1573-8221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"31 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}