{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:42:50Z","timestamp":1790826170123,"version":"4.1.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bull Exp Biol Med"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s10517-025-06421-y","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T04:11:53Z","timestamp":1752811913000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Infarct-Limiting Efficacy of KATP Channel Activators and Nitric Oxide Donors under Conditions of Their Chronic Administration and Diet-Induced Metabolic Syndrome Conditions in Rats"],"prefix":"10.1007","volume":"179","author":[{"given":"N. V.","family":"Naryzhnaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. V.","family":"Mukhomedzyanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kilin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. S.","family":"Voronkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. K.","family":"Kurbatov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. N.","family":"Maslov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"issue":"6","key":"6421_CR1","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1111\/fcp.12924","volume":"37","author":"LN Maslov","year":"2023","unstructured":"Maslov LN, Popov SV, Naryzhnaya NV, et al. KATP channels are regulators of programmed cell death and targets for the creation of novel drugs against ischemia\/reperfusion cardiac injury. Fundam Clin Pharmacol. 2023;37(6):1020-49. https:\/\/doi.org\/10.1111\/fcp.12924","journal-title":"Fundam Clin Pharmacol."},{"issue":"12","key":"6421_CR2","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.3390\/cells12121622","volume":"12","author":"VV Ryabov","year":"2023","unstructured":"Ryabov VV, Vyshlov EV, Maslov LN, et al. The signaling mechanism of remote postconditioning of the heart: prospects of the use of remote postconditioning for the treatment of acute myocardial infarction. Cells. 2023;12(12):1622. https:\/\/doi.org\/10.3390\/cells12121622","journal-title":"Cells."},{"issue":"3","key":"6421_CR3","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s10517-023-05696-3","volume":"174","author":"NV Naryzhnaya","year":"2023","unstructured":"Naryzhnaya NV, Sementsov AS, Maslov LN, et al. The role of NO synthase in the infarct-limiting effect of urgent and chronic adaptation to normobaric hypoxia. Bull Exp Biol Med. 2023;174(3):304-7. https:\/\/doi.org\/10.1007\/s10517-023-05696-3","journal-title":"Bull Exp Biol Med."},{"key":"6421_CR4","doi-asserted-by":"publisher","unstructured":"Aggarwal S, Virdi JK, Singh N, et al. Exploring the role and inter-relationship among nitric oxide, opioids, and KATP channels in the signaling pathway underlying remote ischemic preconditioning induced cardioprotection in rats. Iran J Basic Med Sci. 2019;22(7):820-6. https:\/\/doi.org\/10.22038\/ijbms.2019.34609.8211","DOI":"10.22038\/ijbms.2019.34609.8211"},{"key":"6421_CR5","unstructured":"Pisarenko OI, Serebryakova LI, Tskitishvili OV, et al. The study of vasodilative and antiischemic function of nicorandil in regional ischemia and reperfusion of rat heart in vivo. Cardiology (Moskva). 2008;48(5):36-40. Russian."},{"issue":"3","key":"6421_CR6","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s10517-023-05698-1","volume":"174","author":"SV Logvinov","year":"2023","unstructured":"Logvinov SV, Mukhomedzyanov AV, Kurbatov BK, et al. Participation of leptin and corticosterone in the decrease in infarct-limiting efficiency of remote postconditioning and in the development of arterial hypertension in metabolic syndrome in rats. Bull Exp Biol Med. 2023;174(3):312-7. https:\/\/doi.org\/10.1007\/s10517-023-05698-1","journal-title":"Bull Exp Biol Med."},{"issue":"6","key":"6421_CR7","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s10517-023-05779-1","volume":"174","author":"NV Naryzhnaya","year":"2023","unstructured":"Naryzhnaya NV, Derkachev IA, Kurbatov BK, et al. Decrease in infarct-limiting effect of chronic normobaric hypoxia in rats with induced metabolic syndrome is associated with disturbances of carbohydrate and lipid metabolism. Bull Exp Biol Med. 2023;174(6):723-7. https:\/\/doi.org\/10.1007\/s10517-023-05779-1","journal-title":"Bull Exp Biol Med."},{"issue":"3","key":"6421_CR8","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.neulet.2005.06.036","volume":"387","author":"E Farkas","year":"2005","unstructured":"Farkas E, Timmer NM, Domoki F, et al. Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion. Neurosci Lett. 2005.387(3):168-72. https:\/\/doi.org\/10.1016\/j.neulet.2005.06.036","journal-title":"Neurosci Lett."},{"issue":"8","key":"6421_CR9","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1002\/tox.22111","volume":"31","author":"S Singh","year":"2016","unstructured":"Singh S, Prakash A, Kaur S, et al. The role of multifunctional drug therapy as an antidote to combat experimental subacute neurotoxicity induced by organophos-phate pesticides. Environ Toxicol. 2016;31(8):1017-26. https:\/\/doi.org\/10.1002\/tox.22111","journal-title":"Environ Toxicol."},{"issue":"1","key":"6421_CR10","doi-asserted-by":"publisher","first-page":"H150","DOI":"10.1152\/ajpheart.00114.2018","volume":"315","author":"M Hauerslev","year":"2018","unstructured":"Hauerslev M, M\u00f8rk SR, Pryds K, et al. Influence of long-term treatment with glyceryl trinitrate on remote ischemic conditioning. Am J Physiol Heart Circ Physiol. 2018;315(1):H150-8. https:\/\/doi.org\/10.1152\/ajpheart.00114.2018","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"6421_CR11","doi-asserted-by":"publisher","unstructured":"Logvinov SV, Mustafina LR, Kurbatov BK, et al. Influence of a high-carbohydrate high-fat diet on age-related changes in the myocardium in rats. Siberian Journal of Clinical and Experimental Medicine. 2023;38(1):90-8. Russian. https:\/\/doi.org\/10.29001\/2073-8552-2023-38-1-90-98","DOI":"10.29001\/2073-8552-2023-38-1-90-98"},{"key":"6421_CR12","doi-asserted-by":"publisher","unstructured":"Rose\u2019Meyer RB, Harrison GJ, Fenning A, et al. Chronic dietary L-arginine downregulates adenosine receptor and nitric oxide synthase expression in rat heart. Basic Clin Pharmacol Toxicol. 2008;102(5):459-565. https:\/\/doi.org\/10.1111\/j.1742-7843.2008.00209.x","DOI":"10.1111\/j.1742-7843.2008.00209.x"},{"issue":"2","key":"6421_CR13","doi-asserted-by":"publisher","first-page":"146","DOI":"10.4093\/dmj.2020.0282","volume":"45","author":"JJ Park","year":"2021","unstructured":"Park JJ. Epidemiology, pathophysiology, diagnosis and treatment of heart failure in diabetes. Diabetes Metab J. 2021;45(2):146-57. https:\/\/doi.org\/10.4093\/dmj.2020.0282","journal-title":"Diabetes Metab J."},{"key":"6421_CR14","doi-asserted-by":"publisher","unstructured":"Kraus RM, Houmard JA, Kraus WE, et al. Obesity, insulin resistance, and skeletal muscle nitric oxide synthase. J Appl Physiol (1985). 2012;113(5):758-65. https:\/\/doi.org\/10.1152\/japplphysiol.01018.2011","DOI":"10.1152\/japplphysiol.01018.2011"},{"issue":"2","key":"6421_CR15","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3390\/oxygen2020006","volume":"2","author":"G Martemucci","year":"2022","unstructured":"Martemucci G, Costagliola C, Mariano M, et al. Free radical properties, source and targets, antioxidant consumption and health. Oxygen. 2022;2(2):48-78. https:\/\/doi.org\/10.3390\/oxygen2020006","journal-title":"Oxygen."},{"key":"6421_CR16","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.bbrep.2018.08.005","volume":"16","author":"Q Du","year":"2018","unstructured":"Du Q, Jovanovi\u0107 S, Sukhodub A, Ngoi YS, et al. Insulin down-regulates cardioprotective SUR2A in the heart-derived H9c2 cells: a possible explanation for some adverse effects of insulin therapy. Biochem Biophys Rep. 2018;16:12-8. https:\/\/doi.org\/10.1016\/j.bbrep.2018.08.005","journal-title":"Biochem Biophys Rep."}],"container-title":["Bulletin of Experimental Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-025-06421-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10517-025-06421-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-025-06421-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T05:06:27Z","timestamp":1753419987000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10517-025-06421-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["6421"],"URL":"https:\/\/doi.org\/10.1007\/s10517-025-06421-y","relation":{},"ISSN":["0007-4888","1573-8221"],"issn-type":[{"value":"0007-4888","type":"print"},{"value":"1573-8221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"21 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}