{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:03:23Z","timestamp":1781816603444,"version":"3.54.5"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bull Exp Biol Med"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1007\/s10517-025-06484-x","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T06:59:25Z","timestamp":1758783565000},"page":"331-335","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["\u201cHomeostatic\u201d Cytokines Enhance the Expression of PD-1, Tim-3, and Their Ligands on Myeloid Cells"],"prefix":"10.1007","volume":"179","author":[{"given":"O. Yu.","family":"Leplina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Tikhonova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. V.","family":"Batorov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. V.","family":"Tyrinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. R.","family":"Chernykh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"issue":"10","key":"6484_CR1","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1084\/jem.20100643","volume":"207","author":"K Sakuishi","year":"2010","unstructured":"Sakuishi K, Apetoh L, Sullivan JM, et al. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore antitumor immunity. J Exp Med. 2010;207(10):2187-94. https:\/\/doi.org\/10.1084\/jem.20100643","journal-title":"J Exp Med."},{"key":"6484_CR2","doi-asserted-by":"publisher","unstructured":"Qian Y, Yang T, Liang H, et al. Myeloid checkpoints for cancer immunotherapy. Chin J Cancer Res. 2022;34(5):460-82. https:\/\/doi.org\/10.21147\/j.issn.1000-9604.2022.05.07","DOI":"10.21147\/j.issn.1000-9604.2022.05.07"},{"key":"6484_CR3","doi-asserted-by":"publisher","unstructured":"Rudd CE. A new perspective in cancer immunotherapy: PD-1 on myeloid cells takes center stage in orchestrating immune checkpoint blockade. Sci Immunol. 2020;5(43):eaaz8128. https:\/\/doi.org\/10.1126\/sciimmunol.aaz8128","DOI":"10.1126\/sciimmunol.aaz8128"},{"key":"6484_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.837645","volume":"13","author":"VC Brom","year":"2022","unstructured":"Brom VC, Burger C, Wirtz DC, et al. The role of immune checkpoint molecules on macrophages in cancer, infection, and autoimmune pathologies. Front Immunol. 2022;13:837645. https:\/\/doi.org\/10.3389\/fimmu.2022.837645","journal-title":"Front Immunol."},{"key":"6484_CR5","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nature22396","volume":"545","author":"SR Gordon","year":"2017","unstructured":"Gordon SR, Maute RL, Dulken BW, et al. PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity. Nature. 2017;545:495-9. https:\/\/doi.org\/10.1038\/nature22396","journal-title":"Nature."},{"issue":"1","key":"6484_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41423-019-0306-1","volume":"17","author":"K Nakamura","year":"2020","unstructured":"Nakamura K, Smyth MJ. Myeloid immunosuppression and immune checkpoints in the tumor microenvironment. Cell Mol Immunol. 2020:17(1):1-12. https:\/\/doi.org\/10.1038\/s41423-019-0306-1","journal-title":"Cell Mol Immunol."},{"key":"6484_CR7","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.3389\/fonc.2020.01399","volume":"10","author":"M Kiss","year":"2020","unstructured":"Kiss M, Caro AA, Raes G, et al. Systemic reprogramming of monocytes in cancer. Front Oncol. 2020;10:1399. https:\/\/doi.org\/10.3389\/fonc.2020.01399","journal-title":"Front Oncol."},{"issue":"4","key":"6484_CR8","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1158\/2326-6066.CIR-13-0133","volume":"2","author":"AW MacFarlane 4th","year":"2014","unstructured":"MacFarlane AW 4th, Jillab M, Plimack ER, et al. PD-1 expression on peripheral blood cells increases with stage in renal cell carcinoma patients and is rapidly reduced after surgical tumor resection. Cancer Immunol Res. 2014;2(4):320-31. https:\/\/doi.org\/10.1158\/2326-6066.CIR-13-0133","journal-title":"Cancer Immunol Res."},{"key":"6484_CR9","doi-asserted-by":"publisher","unstructured":"Lehman N, Kowalska W, Zarobkiewicz M, et al. Pro- vs. anti-inflammatory features of monocyte subsets in glioma patients. Int J Mol Sci. 2023;24(3):1879. https:\/\/doi.org\/10.3390\/ijms24031879","DOI":"10.3390\/ijms24031879"},{"issue":"12","key":"6484_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111384","volume":"40","author":"BP Keenan","year":"2022","unstructured":"Keenan BP, McCarthy EE, Ilano A, et al. Circulating monocytes associated with anti-PD-1 resistance in human biliary cancer induce T cell paralysis. Cell Rep. 2022;40(12):111384. https:\/\/doi.org\/10.1016\/j.celrep.2022.111384","journal-title":"Cell Rep."},{"issue":"5","key":"6484_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e26362","volume":"10","author":"T Tyrinova","year":"2024","unstructured":"Tyrinova T, Batorov E, Aristova T, et al. Decreased circulating myeloid-derived suppressor cell count at the engraftment is one of the risk factors for multiple myeloma relapse after autologous hematopoietic stem cell transplantation. Heliyon. 2024;10(5):e26362. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e26362","journal-title":"Heliyon."},{"issue":"3","key":"6484_CR12","first-page":"10","volume":"9","author":"MS Hakim","year":"2020","unstructured":"Hakim MS, Jariah ROA, Spaan M, et al. Interleukin 15 upregulates the expression of PD-1 and TIM-3 on CD4+ and CD8+ T cells. Am J Clin Exp Immunol. 2020;9(3):10-21.","journal-title":"Am J Clin Exp Immunol."},{"key":"6484_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.747324","volume":"12","author":"D Chen","year":"2021","unstructured":"Chen D, Tang TX, Deng H, et al. Interleukin-7 biology and its effects on immune cells: mediator of generation, differentiation, survival, and homeostasis. Front Immunol. 2021;12:747324. https:\/\/doi.org\/10.3389\/fimmu.2021.747324","journal-title":"Front Immunol."},{"issue":"3","key":"6484_CR14","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.clim.2010.01.003","volume":"135","author":"KM Harris","year":"2010","unstructured":"Harris KM, Fasano A, Mann DL. Monocytes differentiated with IL-15 support Th17 and Th1 responses to wheat gliadin: implications for celiac disease. Clin Immunol. 2010;135(3):430-9. https:\/\/doi.org\/10.1016\/j.clim.2010.01.003","journal-title":"Clin Immunol."},{"issue":"1","key":"6484_CR15","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/JLB.5MIR0420-055R","volume":"108","author":"K Bendickova","year":"2020","unstructured":"Bendickova K, Fric J. Roles of IL-2 in bridging adaptive and innate immunity, and as a tool for cellular immunotherapy. J Leukoc Biol. 2020;108(1):427-37. https:\/\/doi.org\/10.1002\/JLB.5MIR0420-055R","journal-title":"J Leukoc Biol."},{"key":"6484_CR16","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3389\/fimmu.2015.00310","volume":"6","author":"SA Fuertes Marraco","year":"2015","unstructured":"Fuertes Marraco SA, Neubert NJ, Verdeil G, et al. Inhibitory receptors beyond T cell exhaustion. Front Immunol. 2015;6:310. https:\/\/doi.org\/10.3389\/fimmu.2015.00310","journal-title":"Front Immunol."},{"key":"6484_CR17","doi-asserted-by":"publisher","first-page":"1632902","DOI":"10.1155\/2018\/1632902","volume":"2018","author":"Q Xia","year":"2018","unstructured":"Xia Q, Wei L, Zhang Y, et al. Immune checkpoint receptors Tim-3 and PD-1 regulate monocyte and T lymphocyte function in septic patients. Mediators Inflamm. 2018;2018:1632902. https:\/\/doi.org\/10.1155\/2018\/1632902","journal-title":"Mediators Inflamm."},{"issue":"8","key":"6484_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072488","volume":"8","author":"CJ Ma","year":"2013","unstructured":"Ma CJ, Li GY, Cheng YQ, et al. Cisassociation of galectin-9 with Tim-3 differentially regulates IL-12\/IL-23 expressions in monocytes via TLR signaling. PLoS One. 2013;8(8):e72488. https:\/\/doi.org\/10.1371\/journal.pone.0072488","journal-title":"PLoS One."},{"issue":"6","key":"6484_CR19","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1016\/j.gendis.2022.05.020","volume":"10","author":"Y Lv","year":"2022","unstructured":"Lv Y, Ma X, Ma Y, et al. A new emerging target in cancer immunotherapy: Galectin-9 (LGALS9). Genes Dis. 2022;10(6):2366-82. https:\/\/doi.org\/10.1016\/j.gendis.2022.05.020","journal-title":"Genes Dis."},{"issue":"3","key":"6484_CR20","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1172\/JCI12173","volume":"108","author":"AN Theofilopoulos","year":"2001","unstructured":"Theofilopoulos AN, Dummer W, Kono DH. T cell homeostasis and systemic autoimmunity. J Clin Invest. 2001;108(3):335-40. https:\/\/doi.org\/10.1172\/JCI12173","journal-title":"J Clin Invest."}],"container-title":["Bulletin of Experimental Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-025-06484-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10517-025-06484-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-025-06484-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T15:16:09Z","timestamp":1759763769000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10517-025-06484-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["6484"],"URL":"https:\/\/doi.org\/10.1007\/s10517-025-06484-x","relation":{},"ISSN":["0007-4888","1573-8221"],"issn-type":[{"value":"0007-4888","type":"print"},{"value":"1573-8221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"25 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}