{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:42:05Z","timestamp":1769276525663,"version":"3.49.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bull Exp Biol Med"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s10517-026-06561-9","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:25:59Z","timestamp":1767986759000},"page":"742-746","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of the C12L, A35R, A40R, and A41L Genes of MVA Vector on the Immunogenicity of Recombinant MVA Expressing the SARS-CoV-2 Spike Protein"],"prefix":"10.1007","volume":"179","author":[{"given":"O. V.","family":"Orlova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. V.","family":"Glazkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. R.","family":"Mintaev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. M.","family":"Tsyganova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. F.","family":"Brazgun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"Shipulin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. V.","family":"Bogoslovskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"6561_CR1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/bs.aivir.2016.07.001","volume":"97","author":"A Volz","year":"2017","unstructured":"Volz A, Sutter G. Modified Vaccinia Virus Ankara: history, value in basic research, and current perspectives for vaccine development. Adv Virus Res. 2017;97:187-243. https:\/\/doi.org\/10.1016\/bs.aivir.2016.07.001","journal-title":"Adv Virus Res."},{"issue":"9","key":"6561_CR2","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.3390\/vaccines10091516","volume":"10","author":"OV Orlova","year":"2022","unstructured":"Orlova OV, Glazkova DV, Bogoslovskaya EV, et al. Development of modified vaccinia virus Ankara-based vaccines: advantages and applications. Vaccines (Basel). 2022;10(9):1516. https:\/\/doi.org\/10.3390\/vaccines10091516","journal-title":"Vaccines (Basel)."},{"issue":"Pt 1","key":"6561_CR3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1099\/vir.0.81417-0","volume":"87","author":"RH Clark","year":"2006","unstructured":"Clark RH, Kenyon JC, Bartlett NW, et al. Deletion of gene A41L enhances vaccinia virus immunogeni city and vaccine efficacy. J Gen Virol. 2006;87(Pt 1):29-38. https:\/\/doi.org\/10.1099\/vir.0.81417-0","journal-title":"J Gen Virol."},{"issue":"1","key":"6561_CR4","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1128\/JVI.01802-09","volume":"84","author":"KE Rehm","year":"2010","unstructured":"Rehm KE, Jones GJ, Tripp AA, et al. The poxvirus A35 protein is an immunoregulator. J Virol. 2010;84(1):418-25. https:\/\/doi.org\/10.1128\/JVI.01802-09","journal-title":"J Virol."},{"issue":"1","key":"6561_CR5","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/vaccines8010070","volume":"8","author":"P P\u00e9rez","year":"2020","unstructured":"P\u00e9rez P, Mar\u00edn MQ, L\u00e1zaro-Fr\u00edas A, et al. Deletion of vaccinia virus A40R gene improves the immunogenicity of the HIV-1 vaccine candidate MVA-B. Vaccines (Basel). 2020;8(1):70. https:\/\/doi.org\/10.3390\/vaccines8010070","journal-title":"Vaccines (Basel)."},{"issue":"2","key":"6561_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032220","volume":"7","author":"J Falivene","year":"2012","unstructured":"Falivene J, Del M\u00e9dico Zajac MP, Pascutti MF, et al. Improving the MVA vaccine potential by deleting the viral gene coding for the IL-18 binding protein. PLoS One. 2012;7(2):e32220. https:\/\/doi.org\/10.1371\/journal.pone.0032220","journal-title":"PLoS One."},{"issue":"2","key":"6561_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001638","volume":"3","author":"MG Cottingham","year":"2008","unstructured":"Cottingham MG, Andersen RF, Spencer AJ, et al. Recombination-mediated genetic engineering of a bacterial artificial chromosome clone of modified vaccinia virus Ankara (MVA). PLoS One. 2008;3(2):e1638. https:\/\/doi.org\/10.1371\/journal.pone.0001638","journal-title":"PLoS One."},{"issue":"6","key":"6561_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128626","volume":"10","author":"NK Alharbi","year":"2015","unstructured":"Alharbi NK, Spencer AJ, Hill AV, et al. Deletion of fifteen open reading frames from modified vaccinia virus Ankara fails to improve immunogeni city. PLoS One. 2015;10(6):e0128626. https:\/\/doi.org\/10.1371\/journal.pone.0128626","journal-title":"PLoS One."},{"key":"6561_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2020.114056","volume":"289","author":"OV Orlova","year":"2021","unstructured":"Orlova OV, Glazkova DV, Tsyganova GM, et al. Application of real-time PCR to significantly reduce the time to obtain recombinant MVA virus. J Virol Methods. 2021;289:114056. https:\/\/doi.org\/10.1016\/j.jviromet.2020.114056","journal-title":"J Virol Methods."},{"issue":"4","key":"6561_CR10","doi-asserted-by":"publisher","first-page":"831","DOI":"10.3390\/vaccines11040831","volume":"11","author":"RR Mintaev","year":"2023","unstructured":"Mintaev RR, Glazkova DV, Orlova OV, et al. Development of MVA-d34 tetravalent dengue vaccine: design and immunogenicity. Vaccines (Basel). 2023;11(4):831. https:\/\/doi.org\/10.3390\/vaccines11040831","journal-title":"Vaccines (Basel)."}],"container-title":["Bulletin of Experimental Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-026-06561-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10517-026-06561-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-026-06561-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T03:43:44Z","timestamp":1769226224000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10517-026-06561-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["6561"],"URL":"https:\/\/doi.org\/10.1007\/s10517-026-06561-9","relation":{},"ISSN":["0007-4888","1573-8221"],"issn-type":[{"value":"0007-4888","type":"print"},{"value":"1573-8221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"4 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}