{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:12:50Z","timestamp":1774419170001,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bull Exp Biol Med"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10517-026-06601-4","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:52:13Z","timestamp":1773201133000},"page":"186-191","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["DOX-Induced Myopathy and Diastolic Stiffness of the Left Ventricular Myocardium of Rat Heart under Conditions of Dobutamine Load"],"prefix":"10.1007","volume":"180","author":[{"given":"A. A.","family":"Abramov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. V.","family":"Prosvirnin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. L.","family":"Lakomkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"issue":"4","key":"6601_CR1","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3322\/caac.21235","volume":"64","author":"CE DeSantis","year":"2014","unstructured":"DeSantis CE, Lin CC, Mariotto AB, et al. Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 2014;64(4):252-71. https:\/\/doi.org\/10.3322\/caac.21235","journal-title":"CA Cancer J Clin."},{"issue":"25","key":"6601_CR2","doi-asserted-by":"publisher","first-page":"3122","DOI":"10.1161\/01.CIR.0000133187.74800.B9","volume":"109","author":"ET Yeh","year":"2004","unstructured":"Yeh ET, Tong AT, Lenihan DJ, et al. Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management. Circulation. 2004;109(25):3122-31. https:\/\/doi.org\/10.1161\/01.CIR.0000133187.74800.B9","journal-title":"Circulation."},{"key":"6601_CR3","unstructured":"Lakomkin VL, Abramov AA, Gramovich VV, et al. The time course of formation of systolic dysfunction of the heart in DOX cardiomyopathy. Cardiology (Moskva). 2017;57(1):59-64. Russian."},{"issue":"6","key":"6601_CR4","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/cpf.12781","volume":"42","author":"P Sj\u00f6berg","year":"2022","unstructured":"Sj\u00f6berg P, Arheden H, Heiberg E, et al. Haemodynamic left-ventricular changes during dobutamine stress in patients with atrial septal defect assessed with magnetic resonance imaging-based pressure-volume loops. Clin Physiol Funct Imaging. 2022;42(6):422-9. https:\/\/doi.org\/10.1111\/cpf.12781","journal-title":"Clin Physiol Funct Imaging."},{"issue":"4","key":"6601_CR5","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s12350-009-9076-y","volume":"16","author":"BA Bart","year":"2009","unstructured":"Bart BA, Cen YY, Hendel RC, et al. Comparison of dobutamine stress echocardiography, dobutamine SPECT, and adenosine SPECT myocardial perfusion imaging in patients with end-stage renal disease. J Nucl Cardiol. 2009;16(4):507-15. https:\/\/doi.org\/10.1007\/s12350-009-9076-y","journal-title":"J Nucl Cardiol."},{"issue":"10","key":"6601_CR6","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1111\/echo.14836","volume":"37","author":"SP Sengupta","year":"2020","unstructured":"Sengupta SP, Mungulmare K, Okwose NC, et al. Comparison of cardiac output estimates by echocardiography and bioreactance at rest and peak dobutamine stress test in heart failure patients with preserved ejection fraction. Echocardiography. 2020;37(10):1603-9. https:\/\/doi.org\/10.1111\/echo.14836","journal-title":"Echocardiography."},{"issue":"1","key":"6601_CR7","doi-asserted-by":"publisher","first-page":"6813","DOI":"10.1038\/s41598-022-10903-8","volume":"12","author":"M Leitman","year":"2022","unstructured":"Leitman M, Balboul Y, Burgsdorf O, et al. Myocardial work index during normal dobutamine stress echocardiography. Sci Rep. 2022;12(1):6813. https:\/\/doi.org\/10.1038\/s41598-022-10903-8","journal-title":"Sci Rep."},{"issue":"3","key":"6601_CR8","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1093\/eurheartj\/ehn492","volume":"30","author":"R Sicari","year":"2009","unstructured":"Sicari R, Nihoyannopoulos P, Evangelista A, et al. Stress Echocardiography Expert Consensus Statement \u2013 Executive Summary: European Association of Echocardiography (EAE) (a registered branch of the ESC). Eur Heart J. 2009;30(3):278-89. https:\/\/doi.org\/10.1093\/eurheartj\/ehn492","journal-title":"Eur Heart J."},{"key":"6601_CR9","doi-asserted-by":"publisher","unstructured":"Alekhin MN, Stepanova AI. Echocardiography in the assessment of postsystolic shortening of the left ventricle myocardium of the heart. Cardiology (Moskva). 2020; 60(12):110-6. Russian. https:\/\/doi.org\/10.18087\/cardio.2020.12.n1087","DOI":"10.18087\/cardio.2020.12.n1087"},{"issue":"2","key":"6601_CR10","doi-asserted-by":"publisher","first-page":"786","DOI":"10.2134\/agronj2012.0506","volume":"107","author":"SV Archontoulis","year":"2015","unstructured":"Archontoulis, SV, Miguez FE. Nonlinear regression models and applications in agricultural research. Agronomy J. 2015;107(2):786-98. https:\/\/doi.org\/10.2134\/agronj2012.0506","journal-title":"Agronomy J."},{"key":"6601_CR11","doi-asserted-by":"publisher","unstructured":"nlme: Linear and Nonlinear Mixed Effects Models. Version 3.1-168. https:\/\/doi.org\/10.32614\/CRAN.package.nlme","DOI":"10.32614\/CRAN.package.nlme"},{"key":"6601_CR12","doi-asserted-by":"publisher","unstructured":"Bates D, M\u00e4chler M, Bolker B, et al. Fitting Linear Mixed-Effects Models Using lme4. J Stat Software. 2015;67(1):1-48. https:\/\/doi.org\/10.18637\/jss.v067.i01","DOI":"10.18637\/jss.v067.i01"},{"key":"6601_CR13","unstructured":"Lenth R. (2025). emmeans: Estimated Marginal Means, aka Least-Squares Means. R package version 1.11.2-00002, https:\/\/rvlenth.github.io\/emmeans\/"},{"key":"6601_CR14","unstructured":"Pustejovsky JE. (2025). clubSandwich: Cluster-Robust (Sandwich) Variance Estimators with Small-Sample Corrections. R package version 0.6.1, http:\/\/jepusto.github.io\/clubSandwich\/"},{"key":"6601_CR15","unstructured":"Boron WF, Boulpaep EL. Medical Physiology, 3rd ed. Elsevier, 2016."},{"issue":"11","key":"6601_CR16","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1161\/01.res.0000021115.24712.99","volume":"90","author":"R Yamasaki","year":"2002","unstructured":"Yamasaki R, Wu Y, McNabb M, et al. Protein kinase A phosphorylates titin\u2019s cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes. Circ Res. 2002;90(11):1181-8. https:\/\/doi.org\/10.1161\/01.res.0000021115.24712.99","journal-title":"Circ Res."},{"key":"6601_CR17","doi-asserted-by":"publisher","unstructured":"Lakomkin VL, Abramov AA, Studneva IM, et al. Early changes of energy metabolism, isoformic content and level of titin phosphorylation at diastolic dysfunction. Cardiology (Moskva). 2020;60(2):4-9. Russian. https:\/\/doi.org\/10.18087\/cardio.2020.3.n531","DOI":"10.18087\/cardio.2020.3.n531"},{"issue":"9","key":"6601_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012733","volume":"5","author":"AV Pointon","year":"2010","unstructured":"Pointon AV, Walker TM, Phillips KM, et al. DOX in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase-3 activation. PLoS One. 2010;5(9):e12733. https:\/\/doi.org\/10.1371\/journal.pone.0012733","journal-title":"PLoS One."},{"issue":"2","key":"6601_CR19","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1124\/mol.119.115725","volume":"96","author":"N Wenningmann","year":"2019","unstructured":"Wenningmann N, Knapp M, Ande A, et al. Insights into DOX-induced cardiotoxicity: molecular mechanisms, preventive strategies, and early monitoring. Mol Pharmacol. 2019;96(2):219-32. https:\/\/doi.org\/10.1124\/mol.119.115725","journal-title":"Mol Pharmacol."},{"issue":"1","key":"6601_CR20","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s10565-006-0140-y","volume":"23","author":"JM Berthiaume","year":"2007","unstructured":"Berthiaume JM, Wallace KB. Adriamycin-induced oxidative mitochondrial cardiotoxicity. Cell Biol Toxicol. 2007;23(1):15-25. https:\/\/doi.org\/10.1007\/s10565-006-0140-y","journal-title":"Cell Biol Toxicol."}],"container-title":["Bulletin of Experimental Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-026-06601-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10517-026-06601-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-026-06601-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:21:02Z","timestamp":1774416062000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10517-026-06601-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["6601"],"URL":"https:\/\/doi.org\/10.1007\/s10517-026-06601-4","relation":{},"ISSN":["0007-4888","1573-8221"],"issn-type":[{"value":"0007-4888","type":"print"},{"value":"1573-8221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"10 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}