{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:08:02Z","timestamp":1779084482471,"version":"3.51.4"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bull Exp Biol Med"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10517-026-06659-0","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:09:52Z","timestamp":1777075792000},"page":"469-471","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differentiation of Late Latent Syphilis and False-Positive Serological Reactions: A Combination of ELISA and Discriminant Analysis"],"prefix":"10.1007","volume":"180","author":[{"given":"N. V.","family":"Arbuzova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. V.","family":"Shpilevaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. L.","family":"Katunin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. E.","family":"Kuznetsov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Yu.","family":"Nosov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Kubanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,25]]},"reference":[{"key":"6659_CR1","doi-asserted-by":"publisher","unstructured":"Kubanov AA, Bogdanova EV. Dermatovenereology in the Russian Federation: Results of 2023. Vestnik Dermatologii i Venerologii. 2024;100(4):9-24. (In Russ.) https:\/\/doi.org\/10.25208\/vdv16795","DOI":"10.25208\/vdv16795"},{"key":"6659_CR2","unstructured":"Clinical Guidelines. Syphilis, 2024. (In Russ.) URL: https:\/\/cr.minzdrav.gov.ru\/view-cr\/197_2"},{"key":"6659_CR3","unstructured":"Dmitriev GA. Laboratory Diagnostics of Syphilis. Syphilis: Phenomenon, Evolution, and Updates. Dmitriev GA, Vasilenko TI, Dol OV, eds. Moscow, 2010. P. 127-207. (In Russ.)"},{"key":"6659_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.574806","volume":"10","author":"Y Luo","year":"2021","unstructured":"Luo Y, Xie Y, Xiao Y. Laboratory diagnostic tools for syphilis: Current status and future prospects. Front Cell Infect Microbiol. 2021;10:574806. https:\/\/doi.org\/10.3389\/fcimb.2020.574806","journal-title":"Front Cell Infect Microbiol."},{"issue":"6","key":"6659_CR5","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1093\/cid\/ciy558","volume":"68","author":"IU Park","year":"2019","unstructured":"Park IU, Fakile YF, Chow JM, et al. Performance of treponemal tests for the diagnosis of syphilis. Clin Infect Dis. 2019;68(6):913-8. https:\/\/doi.org\/10.1093\/cid\/ciy558","journal-title":"Clin Infect Dis."},{"key":"6659_CR6","doi-asserted-by":"publisher","unstructured":"Katunin GL, Rubtsov AB. Using standard serology blood tests to diagnose latent syphilis. Vestnik Dermatologii i Venerologii. 2016;92(3):69-74. (In Russ.) https:\/\/doi.org\/10.25208\/0042-4609-2016-92-3-69-74","DOI":"10.25208\/0042-4609-2016-92-3-69-74"},{"key":"6659_CR7","doi-asserted-by":"publisher","unstructured":"Frigo NV, Zhukova OV, Ptashinskiy RI, et al. Issues of serological diagnosis of syphilis. Interpretation of the results of serological tests. Russian Journal of Clinical Dermatology and Venereology. 2016;15(1):60-8. (In Russ.) https:\/\/doi.org\/10.17116\/klinderma201615160-68","DOI":"10.17116\/klinderma201615160-68"},{"issue":"2","key":"6659_CR8","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.intimp.2014.03.011","volume":"20","author":"F Liu","year":"2014","unstructured":"Liu F, Liu LL, Guo XJ, et al. Characterization of the classical biological false-positive reaction in the serological test for syphilis in the modern era. Int Immunopharmacol. 2014;20(2):331-6. https:\/\/doi.org\/10.1016\/j.intimp.2014.03.011","journal-title":"Int Immunopharmacol."},{"key":"6659_CR9","first-page":"16","volume":"4","author":"NV Frigo","year":"2005","unstructured":"Frigo NV, Kitayeva NV, Rotanov SV. Current aspects of differential diagnosis of false-positive serological reactions to syphilis. Russian Journal of Skin and Venereal Diseases. 2005;(4):16-20. (In Russ.)","journal-title":"Russian Journal of Skin and Venereal Diseases."},{"key":"6659_CR10","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.cca.2018.10.017","volume":"488","author":"W Liu","year":"2019","unstructured":"Liu W, Deng M, Zhang X, et al. Performance of novel infection phase-dependent antigens in syphilis serodiagnosis and treatment efficacy determination. Clin Chim Acta. 2019;488:13-9. https:\/\/doi.org\/10.1016\/j.cca.2018.10.017","journal-title":"Clin Chim Acta."},{"issue":"3","key":"6659_CR11","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02799-24","volume":"13","author":"J Yao","year":"2025","unstructured":"Yao J, Xie B, Ding X, et al. Tp40: a new potential prognostic and diagnostic marker for syphilis. Microbiol Spectr. 2025;13(3):e0279924. https:\/\/doi.org\/10.1128\/spectrum.02799-24","journal-title":"Microbiol Spectr."},{"issue":"3","key":"6659_CR12","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s12088-022-01017-w","volume":"62","author":"JHF de S\u00e1 Queiroz","year":"2022","unstructured":"de S\u00e1 Queiroz JHF, Dos Santos Barbosa M, Miranda LGO, et al. Tp0684, Tp0750, and Tp0792 recombinant proteins as antigens for the serodiagnosis of syphilis. Indian J Microbiol. 2022;62(3):419-27. https:\/\/doi.org\/10.1007\/s12088-022-01017-w","journal-title":"Indian J Microbiol."},{"key":"6659_CR13","doi-asserted-by":"publisher","unstructured":"Potekaev NN, Negasheva ES, Zhukova OV, et al. The use of multidimensional discriminant analysis in the diagnosis of neurosyphilis. Russian Journal of Clinical Dermatology and Venereology. 2019;18(1):18-26. (In Russ.) https:\/\/doi.org\/10.17116\/klinderma20191801118","DOI":"10.17116\/klinderma20191801118"},{"key":"6659_CR14","doi-asserted-by":"publisher","unstructured":"Shpilevaya MV, Katunin GL, Kubanov AA. Developing and researching a discriminant analysis model as a tool for difference of syphilis latent stage from false positive results using 12 antigens Treponema pallidum immunochip. Vestnik Dermatologii i Venerologii. 2021;97(3):39-46. (In Russ.) https:\/\/doi.org\/10.25208\/vdv1229","DOI":"10.25208\/vdv1229"},{"key":"6659_CR15","doi-asserted-by":"publisher","unstructured":"Runina AV, Shpilevaya MV, Katunin GL, et al. Differential serodiagnostics of latent stages of syphilis based on measuring IgG and IgM levels towards extended panel of recombinant antigens of T. pallidum. Bull Exp Biol Med. 2020;169(4):470-3. https:\/\/doi.org\/10.1007\/s10517-020-04911-9","DOI":"10.1007\/s10517-020-04911-9"},{"issue":"8","key":"6659_CR16","doi-asserted-by":"publisher","first-page":"5944","DOI":"10.1074\/jbc.M610215200","volume":"282","author":"RK Deka","year":"2007","unstructured":"Deka RK, Brautigam CA, Tomson FL, et al. Crystal structure of the Tp34 (TP0971) lipoprotein of Treponema pallidum: implications of its metal-bound state and affinity for human lactoferrin. J Biol Chem. 2007;282(8):5944-58. https:\/\/doi.org\/10.1074\/jbc.M610215200","journal-title":"J Biol Chem."}],"container-title":["Bulletin of Experimental Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-026-06659-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10517-026-06659-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-026-06659-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T05:45:12Z","timestamp":1779083112000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10517-026-06659-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["6659"],"URL":"https:\/\/doi.org\/10.1007\/s10517-026-06659-0","relation":{},"ISSN":["0007-4888","1573-8221"],"issn-type":[{"value":"0007-4888","type":"print"},{"value":"1573-8221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"31 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}