{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T02:58:15Z","timestamp":1781233095197,"version":"3.54.1"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bull Exp Biol Med"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s10517-026-06688-9","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:41:59Z","timestamp":1780414919000},"page":"622-626","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Modified Nucleotides on the Immunogenicity of the H1N1 Influenza mRNA Vaccine"],"prefix":"10.1007","volume":"180","author":[{"given":"S. I.","family":"Krasnikova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. V.","family":"Sharabrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. N.","family":"Kisakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. B.","family":"Borgoyakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. V.","family":"Starostina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. V.","family":"Tigeeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. P.","family":"Makarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. A.","family":"Yakovlev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. I.","family":"Ivanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. P.","family":"Rudometov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Ilyichev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. I.","family":"Karpenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"issue":"2","key":"6688_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110680","volume":"39","author":"HK Lee","year":"2022","unstructured":"Lee HK, Knabl L, Moliva JI, et al. mRNA vaccination in octogenarians 15 and 20 months after recovery from COVID-19 elicits robust immune and antibody responses that include Omicron. Cell Rep. 2022;39(2):110680. https:\/\/doi.org\/10.1016\/j.celrep.2022.110680","journal-title":"Cell Rep."},{"key":"6688_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.789427","volume":"9","author":"P Morais","year":"2021","unstructured":"Morais P, Adachi H, Yu YT. The critical contribution of pseudouridine to mRNA COVID-19 vaccines. Front Cell Dev Biol. 2021;9:789427. https:\/\/doi.org\/10.3389\/fcell.2021.789427","journal-title":"Front Cell Dev Biol."},{"key":"6688_CR3","doi-asserted-by":"publisher","unstructured":"Slobodin B, Han R, Calderone V, et al. Transcription impacts the efficiency of mRNA translation via co-transcriptional N6-adenosine methylation. Cell. 2017;169(2):326-37. e12. https:\/\/doi.org\/10.1016\/j.cell.2017.03.031","DOI":"10.1016\/j.cell.2017.03.031"},{"issue":"11","key":"6688_CR4","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1038\/mt.2008.200","volume":"16","author":"K Karik\u00f3","year":"2008","unstructured":"Karik\u00f3 K, Muramatsu H, Welsh FA, et al. Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. Mol Ther. 2008;16(11):1833-40. https:\/\/doi.org\/10.1038\/mt.2008.200","journal-title":"Mol Ther."},{"key":"6688_CR5","doi-asserted-by":"publisher","first-page":"1286820","DOI":"10.3389\/fimmu.2023.1286820","volume":"14","author":"S Shen","year":"2023","unstructured":"Shen S, Zhang LS. The regulation of antiviral innate immunity through non-m6A RNA modifications. Front Immunol. 2023;14:1286820. https:\/\/doi.org\/10.3389\/fimmu.2023.1286820","journal-title":"Front Immunol."},{"issue":"1","key":"6688_CR6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13578-025-01368-z","volume":"15","author":"T Shi","year":"2025","unstructured":"Shi T, Zhang H, Chen Y. The m6A revolution: transforming tumor immunity and enhancing immunotherapy outcomes. Cell Biosci. 2025;15(1):27. https:\/\/doi.org\/10.1186\/s13578-025-01368-z","journal-title":"Cell Biosci."},{"issue":"1","key":"6688_CR7","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s40364-022-00362-8","volume":"10","author":"H Song","year":"2022","unstructured":"Song H, Zhang J, Liu B, et al. Biological roles of RNA m5C modification and its implications in cancer immunotherapy. Biomark Res. 2022;10(1):15. https:\/\/doi.org\/10.1186\/s40364-022-00362-8","journal-title":"Biomark Res."},{"issue":"2","key":"6688_CR8","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.immuni.2005.06.008","volume":"23","author":"K Karik\u00f3","year":"2005","unstructured":"Karik\u00f3 K, Buckstein M, Ni H, et al. Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity. 2005;23(2):165-75. https:\/\/doi.org\/10.1016\/j.immuni.2005.06.008","journal-title":"Immunity."},{"key":"6688_CR9","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.jconrel.2021.11.022","volume":"341","author":"JR Melamed","year":"2022","unstructured":"Melamed JR, Hajj KA, Chaudhary N, et al. Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery. J Control Release. 2022;341:206-14. https:\/\/doi.org\/10.1016\/j.jconrel.2021.11.022","journal-title":"J Control Release."},{"issue":"3","key":"6688_CR10","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1021\/acs.bioconjchem.6b00090","volume":"27","author":"B Li","year":"2016","unstructured":"Li B, Luo X, Dong Y. Effects of chemically modified messenger RNA on protein expression. Bioconjug Chem. 2016;27(3):849-53. https:\/\/doi.org\/10.1021\/acs.bioconjchem.6b00090","journal-title":"Bioconjug Chem."},{"issue":"10","key":"6688_CR11","doi-asserted-by":"publisher","first-page":"6023","DOI":"10.1093\/nar\/gkx135","volume":"45","author":"YV Svitkin","year":"2017","unstructured":"Svitkin YV, Cheng YM, Chakraborty T, et al. N1-methyl-pseudouridine in mRNA enhances translation through eIF2\u03b1-dependent and independent mechanisms by increasing ribosome density. Nucleic Acids Res. 2017;45(10):6023-36. https:\/\/doi.org\/10.1093\/nar\/gkx135","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"6688_CR12","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1134\/S0026893325700062","volume":"59","author":"SV Sharabrin","year":"2025","unstructured":"Sharabrin SV, Ilyichev AA, Kisakov DN, et al. Needle-Free Jet-Delivered mRNA-Vaccine Encoding Influenza A(H1N1)pdm09 Hemagglutinin Protects Mice from Lethal Virus Infection. Moll Biol. 2025;59(3):376-8. https:\/\/doi.org\/10.1134\/S0026893325700062","journal-title":"Moll Biol."},{"issue":"5","key":"6688_CR13","doi-asserted-by":"publisher","first-page":"452","DOI":"10.3390\/vaccines9050452","volume":"9","author":"EV Starostina","year":"2021","unstructured":"Starostina EV, Sharabrin SV, Antropov DN, et al. Construction and immunogenicity of modified mRNA vaccine variants encoding influenza virus antigens. Vaccines (Basel). 2021;9(5):452. https:\/\/doi.org\/10.3390\/vaccines9050452","journal-title":"Vaccines (Basel)."}],"container-title":["Bulletin of Experimental Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-026-06688-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10517-026-06688-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-026-06688-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T02:50:07Z","timestamp":1781232607000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10517-026-06688-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["6688"],"URL":"https:\/\/doi.org\/10.1007\/s10517-026-06688-9","relation":{},"ISSN":["0007-4888","1573-8221"],"issn-type":[{"value":"0007-4888","type":"print"},{"value":"1573-8221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"22 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}