{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T07:28:58Z","timestamp":1786778938053,"version":"build-2736575974"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bull Exp Biol Med"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s10517-026-06702-0","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:14:51Z","timestamp":1785168891000},"page":"703-706","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Melatonin in Original Rectal Suppositories on the Neurological Status and Mucosa-Associated and Luminal Microbiota of the Distal Colon in Wistar Rats with Experimental Acute Cerebral Ischemia"],"prefix":"10.1007","volume":"180","author":[{"given":"Yu. S.","family":"Shishkova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. V.","family":"Osikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Boyko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. V.","family":"Shelomentsev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Zotova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Fedosov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"issue":"1","key":"6702_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1177\/17474930211065917","volume":"17","author":"VL Feigin","year":"2022","unstructured":"Feigin VL, Brainin M, Norrving B, et al. World stroke organization (WSO): Global stroke fact sheet 2022. Int J Stroke. 2022;17(1):18-29. https:\/\/doi.org\/10.1177\/17474930211065917","journal-title":"Int J Stroke."},{"key":"6702_CR2","doi-asserted-by":"publisher","unstructured":"Ignatyeva VI, Voznyuk IA, Shamalov NA, et al. Social and economic burden of stroke in Russian Federation. S. S. Korsakov Journal of Neurology and Psychiatry. 2023;123(8-2):5-15. (In Russ.). https:\/\/doi.org\/10.17116\/jnevro20231230825","DOI":"10.17116\/jnevro20231230825"},{"issue":"8","key":"6702_CR3","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1161\/CIRCRESAHA.122.319983","volume":"130","author":"P Honarpisheh","year":"2022","unstructured":"Honarpisheh P, Bryan RM, McCullough LD. Aging microbiota-gut-brain axis in stroke risk and outcome. Circ Res. 2022;130(8):1112-44. https:\/\/doi.org\/10.1161\/CIRCRESAHA.122.319983","journal-title":"Circ Res."},{"issue":"8","key":"6702_CR4","doi-asserted-by":"publisher","first-page":"559","DOI":"10.3390\/metabo11080559","volume":"11","author":"S Akagawa","year":"2021","unstructured":"Akagawa S, Akagawa Y, Nakai Y, et al. Fiber-rich barley increases butyric acid-producing bacteria in the human gut microbiota. Metabolites. 2021;11(8):559. https:\/\/doi.org\/10.3390\/metabo11080559","journal-title":"Metabolites."},{"issue":"4","key":"6702_CR5","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/s41430-021-00986-3","volume":"76","author":"X Chen","year":"2022","unstructured":"Chen X, Hu Y, Yuan X, et al. Effect of early enteral nutrition combined with probiotics in patients with stroke: A meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2022;76(4):592-603. https:\/\/doi.org\/10.1038\/s41430-021-00986-3","journal-title":"Eur J Clin Nutr."},{"issue":"1","key":"6702_CR6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13073-016-0294-z","volume":"8","author":"A Langdon","year":"2016","unstructured":"Langdon A, Crook N, Dantas G. The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation. Genome Med. 2016;8(1):39. https:\/\/doi.org\/10.1186\/s13073-016-0294-z","journal-title":"Genome Med."},{"key":"6702_CR7","doi-asserted-by":"publisher","first-page":"1060581","DOI":"10.3389\/fmed.2022.1060581","volume":"9","author":"S Hamamah","year":"2022","unstructured":"Hamamah S, Gheorghita R, Lobiuc A, et al. Fecal microbiota transplantation in non-communicable diseases: Recent advances and protocols. Front Med (Lausanne). 2022;9:1060581. https:\/\/doi.org\/10.3389\/fmed.2022.1060581","journal-title":"Front Med (Lausanne)."},{"key":"6702_CR8","doi-asserted-by":"publisher","first-page":"1489834","DOI":"10.3389\/fphar.2024.1489834","volume":"15","author":"M Gao","year":"2024","unstructured":"Gao M, Li J, Han X, et al. Effect of melatonin on gut microbiome and metabolomics in diabetic cognitive impairment. Front Pharmacol. 2024;15:1489834. https:\/\/doi.org\/10.3389\/fphar.2024.1489834","journal-title":"Front Pharmacol."},{"issue":"3","key":"6702_CR9","doi-asserted-by":"publisher","first-page":"325","DOI":"10.5217\/ir.2019.00093","volume":"18","author":"YS Park","year":"2020","unstructured":"Park YS, Kim SH, Park JW, et al. Melatonin in the colon modulates intestinal microbiota in response to stress and sleep deprivation. Intest Res. 2020;18(3):325-36. https:\/\/doi.org\/10.5217\/ir.2019.00093","journal-title":"Intest Res."},{"key":"6702_CR10","unstructured":"Osikov MV, Shishkova YuS, Shelomentsev AV. Modern ideas about the interaction between melatonin, local immunity and intestinal microbiota: role in central nervous system pathology. \u00db\u017eno-Ural'skij Medicinskij \u017durnal. 2024;(1):69-78. (In Russ.)."},{"key":"6702_CR11","unstructured":"Osikov MV, Ushakova VA, Grekova IV, et al. Patent RU No. 2819721. Melatonin agent for treating inflammatory bowel diseases in the form of rectal suppositories. Bull. No. 15. Published May 23, 2024."},{"issue":"4","key":"6702_CR12","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1161\/01.str.17.4.738","volume":"17","author":"ST Chen","year":"1986","unstructured":"Chen ST, Hsu CY, Hogan EL, et al. A model of focal ischemic stroke in the rat: reproducible extensive cortical infarction. Stroke. 1986;17(4):738-43. https:\/\/doi.org\/10.1161\/01.str.17.4.738","journal-title":"Stroke."},{"key":"6702_CR13","first-page":"56","volume":"5","author":"DV Kadomtsev","year":"2015","unstructured":"Kadomtsev DV, Pasechnikova EA, Golubev VG. Zoletil-xylazine anesthesia experiments in rats. International Journal of Applied and Fundamental Research. 2015;(5):56-7. (In Russ.).","journal-title":"International Journal of Applied and Fundamental Research."},{"key":"6702_CR14","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1093\/acprof:oso\/9780195162851.003.0012","volume-title":"The behavior of the laboratory rat: a handbook with tests","author":"MT Schallert","year":"2004","unstructured":"Schallert MT, Whishaw IQ, O\u2019Brien JT. Simple and complex sensorimotor functions. In: Whishaw IQ, Kolb B, editors. The behavior of the laboratory rat: a handbook with tests. Oxford: Oxford University Press; 2004. P. 129-40."},{"issue":"1","key":"6702_CR15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/2040-7378-2-13","volume":"2","author":"KL Schaar","year":"2010","unstructured":"Schaar KL, Brenneman MM, Savitz SI. Functional assessments in the rodent stroke model. Exp Transl Stroke Med. 2010;2(1):13. https:\/\/doi.org\/10.1186\/2040-7378-2-13","journal-title":"Exp Transl Stroke Med."},{"issue":"4","key":"6702_CR16","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s10517-025-06503-x","volume":"179","author":"MV Osikov","year":"2025","unstructured":"Osikov MV, Boyko MS, Shelomentsev AV, et al. Neuroprotective effect of melatonin in original rectal suppositories in experimental acute cerebral ischemia in rats. Bull Exp Biol Med. 2025;179(4):425-9. https:\/\/doi.org\/10.1007\/s10517-025-06503-x","journal-title":"Bull Exp Biol Med."},{"key":"6702_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.683879","volume":"12","author":"F He","year":"2021","unstructured":"He F, Wu X, Zhang Q, et al. Bacteriostatic potential of melatonin: therapeutic standing and mechanistic insights. Front Immunol. 2021;12:683879. https:\/\/doi.org\/10.3389\/fimmu.2021.683879","journal-title":"Front Immunol."},{"key":"6702_CR18","doi-asserted-by":"publisher","unstructured":"Kim AD, Goldberg OA, Lepekhova SA, et al. Peculiarities of topographic anatomy and crypt compartment of distal colon in Wistar rats. Acta Biomedica Scientifica. 2016;1(2):48-54 (In Russ.). https:\/\/doi.org\/10.12737\/20615","DOI":"10.12737\/20615"}],"container-title":["Bulletin of Experimental Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-026-06702-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10517-026-06702-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-026-06702-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T07:16:05Z","timestamp":1786778165000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10517-026-06702-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["6702"],"URL":"https:\/\/doi.org\/10.1007\/s10517-026-06702-0","relation":{},"ISSN":["0007-4888","1573-8221"],"issn-type":[{"value":"0007-4888","type":"print"},{"value":"1573-8221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"7 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}