{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T07:28:56Z","timestamp":1786778936993,"version":"build-2736575974"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bull Exp Biol Med"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s10517-026-06704-y","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:17:59Z","timestamp":1785169079000},"page":"713-718","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dose-Dependent Angiogenic Effects of Intravenous Nicotinamide Riboside in Mice with a Lewis Lung Carcinoma Model"],"prefix":"10.1007","volume":"180","author":[{"given":"E. Y.","family":"Podyacheva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Y.","family":"Semenova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. A.","family":"Makhnin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. A.","family":"Simushova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. E.","family":"Artyukhina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. V.","family":"Snezhkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. D.","family":"Belogortseva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. A.","family":"Zinserling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya. G.","family":"Toropova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"6704_CR1","doi-asserted-by":"publisher","first-page":"1291530","DOI":"10.3389\/fimmu.2023.1291530","volume":"14","author":"C Qian","year":"2023","unstructured":"Qian C, Liu C, Liu W, et al. Targeting vascular normalization: A promising strategy to improve immunevascular crosstalk in cancer immunotherapy. Front Immunol. 2023;14:1291530. https:\/\/doi.org\/10.3389\/fimmu.2023.1291530","journal-title":"Front Immunol."},{"issue":"3","key":"6704_CR2","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/s41416-021-01330-z","volume":"125","author":"AL Magnussen","year":"2021","unstructured":"Magnussen AL, Mills IG. Vascular normalisation as the stepping stone into tumour microenvironment transformation. Br J Cancer. 2021;125(3):324-36. https:\/\/doi.org\/10.1038\/s41416-021-01330-z","journal-title":"Br J Cancer."},{"key":"6704_CR3","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1146\/annurev-physiol-020518-114700","volume":"81","author":"JD Martin","year":"2019","unstructured":"Martin JD, Seano G, Jain RK. Normalizing function of tumor vessels: progress, opportunities, and challenges. Annu Rev Physiol. 2019;81:505-34. https:\/\/doi.org\/10.1146\/annurev-physiol-020518-114700","journal-title":"Annu Rev Physiol."},{"issue":"10","key":"6704_CR4","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1111\/bph.15096","volume":"178","author":"A Buqu\u00e9","year":"2021","unstructured":"Buqu\u00e9 A, Bloy N, Kroemer G, et al. Possible mechanisms of cancer prevention by nicotinamide. Br J Pharmacol. 2021;178(10):2034-40. https:\/\/doi.org\/10.1111\/bph.15096","journal-title":"Br J Pharmacol."},{"issue":"1","key":"6704_CR5","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3390\/nu16010100","volume":"16","author":"G Tosti","year":"2023","unstructured":"Tosti G, Pepe F, Gnagnarella P, et al. The role of nicotinamide as chemo-preventive agent in NMSCs: A systematic review and meta-analysis. Nutrients. 2023;16(1):100. https:\/\/doi.org\/10.3390\/nu16010100","journal-title":"Nutrients."},{"issue":"3","key":"6704_CR6","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3390\/biom10030477","volume":"10","author":"IP Nikas","year":"2020","unstructured":"Nikas IP, Paschou SA, Ryu HS. The role of nicotinamide in cancer chemoprevention and therapy. Biomolecules. 2020;10(3):477. https:\/\/doi.org\/10.3390\/biom10030477","journal-title":"Biomolecules."},{"issue":"9","key":"6704_CR7","doi-asserted-by":"publisher","first-page":"7925","DOI":"10.3390\/ijms24097925","volume":"24","author":"E Podyacheva","year":"2023","unstructured":"Podyacheva E, Toropova Y. The role of NAD+, SIRTs interactions in stimulating and counteracting carcinogenesis. Int J Mol Sci. 2023;24(9):7925. https:\/\/doi.org\/10.3390\/ijms24097925","journal-title":"Int J Mol Sci."},{"issue":"6","key":"6704_CR8","doi-asserted-by":"publisher","first-page":"339","DOI":"10.14740\/cr1416","volume":"13","author":"E Podyacheva","year":"2022","unstructured":"Podyacheva E, Shmakova T, Kushnareva E, et al. Modeling doxorubicin-induced cardiomyopathy with fibrotic myocardial damage in Wistar rats. Cardiol Res. 2022;13(6):339-56. https:\/\/doi.org\/10.14740\/cr1416","journal-title":"Cardiol Res."},{"key":"6704_CR9","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1134\/S0022093025020036","volume":"61","author":"EY Podyacheva","year":"2025","unstructured":"Podyacheva EY, Semenova NY, Mukhametdinova DV, et al. Biocompatibility of different nicotinamide riboside doses administered intravenously to rats. J Evol Biochem Phys. 2025;61:396-410. https:\/\/doi.org\/10.1134\/S0022093025020036","journal-title":"J Evol Biochem Phys."},{"key":"6704_CR10","doi-asserted-by":"publisher","unstructured":"Nefedova NA, Kharlova OA, Danilova NV, et al. Markers of angiogenesis in tumor growth. Archive of Pathology. 2016;78(2):55-63. (In Russ.). https:\/\/doi.org\/10.17116\/patol201678255-62","DOI":"10.17116\/patol201678255-62"},{"issue":"6","key":"6704_CR11","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1111\/jphp.12539","volume":"68","author":"AM Meredith","year":"2016","unstructured":"Meredith AM, Dass CR. Increasing role of the cancer chemotherapeutic doxorubicin in cellular metabolism. J Pharm Pharmacol. 2016;68(6):729-41. https:\/\/doi.org\/10.1111\/jphp.12539","journal-title":"J Pharm Pharmacol."},{"key":"6704_CR12","doi-asserted-by":"publisher","first-page":"15798","DOI":"10.1038\/srep15798","volume":"5","author":"HJ Shin","year":"2015","unstructured":"Shin HJ, Kwon HK, Lee JH, et al. Doxorubicin-induced necrosis is mediated by poly-(ADP-ribose) polymerase 1 (PARP1) but is independent of p53. Sci Rep. 2015;5:15798. https:\/\/doi.org\/10.1038\/srep15798","journal-title":"Sci Rep."},{"issue":"10","key":"6704_CR13","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s11306-019-1604-4","volume":"15","author":"SB Song","year":"2019","unstructured":"Song SB, Park JS, Chung GJ, et al. Diverse therapeutic efficacies and more diverse mechanisms of nicotinamide. Metabolomics. 2019;15(10):137. https:\/\/doi.org\/10.1007\/s11306-019-1604-4","journal-title":"Metabolomics."},{"issue":"11","key":"6704_CR14","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.trecan.2024.08.003","volume":"10","author":"AL Harris","year":"2024","unstructured":"Harris AL, Kerr DJ, Pezzella F, et al. Accessing the vasculature in cancer: revising an old hallmark. Trends Cancer. 2024;10(11):1038-51. https:\/\/doi.org\/10.1016\/j.trecan.2024.08.003","journal-title":"Trends Cancer."},{"key":"6704_CR15","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1126\/science.1104819","volume":"307","author":"RK Jain","year":"2005","unstructured":"Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science. 2005;307:58-62. https:\/\/doi.org\/10.1126\/science.1104819","journal-title":"Science."},{"issue":"4","key":"6704_CR16","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s10456-017-9562-9","volume":"20","author":"C Viallard","year":"2017","unstructured":"Viallard C, Larriv\u00e9e B. Tumor angiogenesis and vascular normalization: alternative therapeutic targets. Angiogenesis. 2017;20(4):409-26. https:\/\/doi.org\/10.1007\/s10456-017-9562-9","journal-title":"Angiogenesis."},{"issue":"10","key":"6704_CR17","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.3390\/ijms18102111","volume":"18","author":"L Wang","year":"2017","unstructured":"Wang L, Liang C, Li F, et al. PARP1 in carcinomas and PARP1 inhibitors as antineoplastic drugs. Int J Mol Sci. 2017;18(10):2111. https:\/\/doi.org\/10.3390\/ijms18102111","journal-title":"Int J Mol Sci."},{"issue":"5","key":"6704_CR18","doi-asserted-by":"publisher","first-page":"687","DOI":"10.2174\/1871520619666190114160457","volume":"19","author":"Y Wei","year":"2019","unstructured":"Wei Y, Guo Y, Zhou J, et al. Nicotinamide overcomes doxorubicin resistance of breast cancer cells through deregulating SIRT1\/Akt pathway. Anticancer Agents Med Chem. 2019;19(5):687-96. https:\/\/doi.org\/10.2174\/1871520619666190114160457","journal-title":"Anticancer Agents Med Chem."},{"issue":"17","key":"6704_CR19","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1056\/NEJMoa1506197","volume":"373","author":"AC Chen","year":"2015","unstructured":"Chen AC, Martin AJ, Choy B, et al. A phase 3 randomized trial of nicotinamide for skin-cancer chemoprevention. N Engl J Med. 2015;373(17):1618-26. https:\/\/doi.org\/10.1056\/NEJMoa1506197","journal-title":"N Engl J Med."},{"issue":"5","key":"6704_CR20","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1038\/jid.2011.459","volume":"132","author":"D Surjana","year":"2012","unstructured":"Surjana D, Halliday GM, Martin AJ, et al. Oral nicotinamide reduces actinic keratoses in phase II double-blinded randomized controlled trials. J Invest Dermatol. 2012;132(5):1497-500. https:\/\/doi.org\/10.1038\/jid.2011.459","journal-title":"J Invest Dermatol."}],"container-title":["Bulletin of Experimental Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-026-06704-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10517-026-06704-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-026-06704-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T07:15:56Z","timestamp":1786778156000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10517-026-06704-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["6704"],"URL":"https:\/\/doi.org\/10.1007\/s10517-026-06704-y","relation":{},"ISSN":["0007-4888","1573-8221"],"issn-type":[{"value":"0007-4888","type":"print"},{"value":"1573-8221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"30 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}