{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T05:39:59Z","timestamp":1792474799695,"version":"4.5.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bull Exp Biol Med"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s10517-026-06728-4","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:20:49Z","timestamp":1790083249000},"page":"69-72","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Liver Structure after Administration of Autophagy-Modifying Drugs in Mice with Experimental Skin Melanoma"],"prefix":"10.1007","volume":"181","author":[{"given":"E. A.","family":"Telpukhovskaia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Karpov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. P.","family":"Bgatova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. V.","family":"Klimontov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iu. S.","family":"Taskaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"issue":"2","key":"6728_CR1","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/s11864-023-01053-8","volume":"24","author":"C Pangilinan","year":"2023","unstructured":"Pangilinan C, Xu X, Herlyn M, et al. Autophagy paradox: strategizing treatment modality in melanoma. Curr Treat Options Oncol. 2023;24(2):130-45. https:\/\/doi.org\/10.1007\/s11864-023-01053-8","journal-title":"Curr Treat Options Oncol."},{"issue":"4","key":"6728_CR2","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.coph.2011.03.009","volume":"11","author":"EL Eskelinen","year":"2011","unstructured":"Eskelinen EL. The dual role of autophagy in cancer. Curr Opin Pharmacol. 2011;11(4):294-300. https:\/\/doi.org\/10.1016\/j.coph.2011.03.009","journal-title":"Curr Opin Pharmacol."},{"issue":"4","key":"6728_CR3","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1007\/s10637-021-01089-3","volume":"39","author":"OO Ryabaya","year":"2021","unstructured":"Ryabaya OO, Abramov IS, Khochenkov DA, et al. Rapamycin synergizes the cytotoxic effects of MEK inhibitor binimetinib and overcomes acquired resistance to therapy in melanoma cell lines in vitro. Invest New Drugs. 2021;39(4):987-1000. https:\/\/doi.org\/10.1007\/s10637-021-01089-3","journal-title":"Invest New Drugs."},{"issue":"4","key":"6728_CR4","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3892\/ol.2024.14273","volume":"27","author":"P Wang","year":"2024","unstructured":"Wang P, Zhang H, Guo K, et al. Rapamycin inhibits B16 melanoma cell viability in vitro and in vivo by inducing autophagy and inhibiting the mTOR\/p70-S6k pathway. Oncol Lett. 2024;27(4):140. https:\/\/doi.org\/10.3892\/ol.2024.14273","journal-title":"Oncol Lett."},{"key":"6728_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S1431927622000745","volume":"20","author":"I Taskaeva","year":"2022","unstructured":"Taskaeva I, Gogaeva I, Shatruk A, et al. Lithium enhances autophagy and cell death in skin melanoma: an ultrastructural and immunohistochemical study. Microsc Microanal. 2022;20:1-9. https:\/\/doi.org\/10.1017\/S1431927622000745","journal-title":"Microsc Microanal."},{"issue":"17","key":"6728_CR6","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1101\/gad.287524.116","volume":"30","author":"R Amaravadi","year":"2016","unstructured":"Amaravadi R, Kimmelman AC, White E. Recent insights into the function of autophagy in cancer. Genes Dev. 2016;30(17):1913-30. https:\/\/doi.org\/10.1101\/gad.287524.116","journal-title":"Genes Dev."},{"issue":"2","key":"6728_CR7","doi-asserted-by":"publisher","first-page":"408","DOI":"10.3390\/microorganisms11020408","volume":"11","author":"Z Yu","year":"2023","unstructured":"Yu Z, Zhao Y, Ding K, et al. Chloroquine inhibition of auto-phagy enhanced the anticancer effects of listeria monocytogenes in melanoma. Microorganisms. 2023;11(2):408. https:\/\/doi.org\/10.3390\/microorganisms11020408","journal-title":"Microorganisms."},{"issue":"1","key":"6728_CR8","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1158\/0008-5472.CAN-12-2464","volume":"73","author":"T Kimura","year":"2013","unstructured":"Kimura T, Takabatake Y, Takahashi A, et al. Chloroquine in cancer therapy: a double-edged sword of autophagy. Cancer Res. 2013;73(1):3-7. https:\/\/doi.org\/10.1158\/0008-5472.CAN-12-2464","journal-title":"Cancer Res."},{"issue":"18","key":"6728_CR9","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.3390\/cancers16183217","volume":"16","author":"N Abu Rached","year":"2024","unstructured":"Abu Rached N, Reis MMDS, Stockfleth E, et al. Analysis of calculated liver scores for long-term outcome in 423 cutaneous melanoma patients. Cancers (Basel). 2024;16(18):3217. https:\/\/doi.org\/10.3390\/cancers16183217","journal-title":"Cancers (Basel)."},{"key":"6728_CR10","doi-asserted-by":"publisher","unstructured":"Brodsky VYa, Kudryavtsev BN, Bezborodkina NN. Cell polyploidy. Cardiac muscle. Liver. Ontogenesis and regeneration. \u017durnal Ob'ej Biologii. 2024;85(1):47-61. (In Russ.). https:\/\/doi.org\/10.31857\/S0044459624010047","DOI":"10.31857\/S0044459624010047"},{"issue":"1","key":"6728_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/path.2697","volume":"221","author":"D Glick","year":"2010","unstructured":"Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. J Pathol. 2010;221(1):3-12. https:\/\/doi.org\/10.1002\/path.2697","journal-title":"J Pathol."},{"issue":"6","key":"6728_CR12","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1002\/ijc.20972","volume":"115","author":"E Erdal","year":"2005","unstructured":"Erdal E, Ozturk N, Cagatay T, et al. Lithium-mediated downregulation of PKB\/Akt and cyclin E with growth inhibition in hepatocellular carcinoma cells. Int J Cancer. 2005;115(6):903-10. https:\/\/doi.org\/10.1002\/ijc.20972","journal-title":"Int J Cancer."},{"issue":"9\u201310","key":"6728_CR13","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.lfs.2012.07.027","volume":"91","author":"MM Tsui","year":"2012","unstructured":"Tsui MM, Tai WC, Wong WY, et al. Selective G2\/M arrest in a p53(Val135)-transformed cell line induced by lithium is mediated through an intricate network of MAPK and \u03b2-catenin signaling pathways. Life Sci. 2012;91(9-10):312-21. https:\/\/doi.org\/10.1016\/j.lfs.2012.07.027","journal-title":"Life Sci."},{"issue":"7","key":"6728_CR14","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1083\/jcb.200504035","volume":"170","author":"S Sarkar","year":"2005","unstructured":"Sarkar S, Floto RA, Berger Z, et al. Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol. 2005;170(7):1101-11. https:\/\/doi.org\/10.1083\/jcb.200504035","journal-title":"J Cell Biol."},{"key":"6728_CR15","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/978-1-59745-157-4_4","volume":"445","author":"I Tanida","year":"2008","unstructured":"Tanida I, Ueno T, Kominami E. LC3 and autophagy. Methods Mol Biol. 2008;445:77-88. https:\/\/doi.org\/10.1007\/978-1-59745-157-4_4","journal-title":"Methods Mol Biol."},{"issue":"1","key":"6728_CR16","first-page":"101","volume":"1","author":"AT Nguyen-Lefebvre","year":"2015","unstructured":"Nguyen-Lefebvre AT, Horuzsko A. Kupffer cell metabolism and function. J Enzymol Metab. 2015;1(1):101.","journal-title":"J Enzymol Metab."}],"container-title":["Bulletin of Experimental Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-026-06728-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10517-026-06728-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-026-06728-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T05:14:16Z","timestamp":1792473256000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10517-026-06728-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["6728"],"URL":"https:\/\/doi.org\/10.1007\/s10517-026-06728-4","relation":{},"ISSN":["0007-4888","1573-8221"],"issn-type":[{"value":"0007-4888","type":"print"},{"value":"1573-8221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"11 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}