{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:32:14Z","timestamp":1793302334009,"version":"4.5.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bull Exp Biol Med"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s10517-026-06749-z","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:49:20Z","timestamp":1790783360000},"page":"200-205","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurotrophic and Neuroprotective Effects of Magnesium Chelidonate and Chelidonic Acid in Cell Culture Experiments"],"prefix":"10.1007","volume":"181","author":[{"given":"S. V.","family":"Kozin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Kravtsov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. V.","family":"Moiseev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. D.","family":"Rubailo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. V.","family":"Bobrovnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. R.","family":"Vasilevskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. I.","family":"Trofimenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. M.","family":"Lyasota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"6749_CR1","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.2147\/NDT.S230688","volume":"15","author":"Y Shen","year":"2019","unstructured":"Shen Y, Dai L, Tian H, et al. Treatment of Magnesium-L-threonate elevates the magnesium level in the cerebrospinal fluid and attenuates motor deficits and dopamine neuron loss in a mouse model of Parkinson\u2019s disease. Neuropsychiatr Dis Treat. 2019;15:3143-53. https:\/\/doi.org\/10.2147\/NDT.S230688","journal-title":"Neuropsychiatr Dis Treat."},{"issue":"13","key":"6749_CR2","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.3390\/nu17132216","volume":"17","author":"P Varga","year":"2025","unstructured":"Varga P, Lehoczki A, Fekete M, et al. The role of magnesium in depression, migraine, Alzheimer\u2019s disease, and cognitive health: A comprehensive review. Nutrients. 2025;17(13):2216. https:\/\/doi.org\/10.3390\/nu17132216","journal-title":"Nutrients."},{"key":"6749_CR3","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.intimp.2016.08.009","volume":"40","author":"DK Singh","year":"2016","unstructured":"Singh DK, Gulati K, Ray A. Effects of chelidonic acid, a secondary plant metabolite, on mast cell degranulation and adaptive immunity in rats. Int Immunopharmacol. 2016;40:229-34. https:\/\/doi.org\/10.1016\/j.intimp.2016.08.009","journal-title":"Int Immunopharmacol."},{"issue":"6","key":"6749_CR4","doi-asserted-by":"publisher","first-page":"432","DOI":"10.55730\/1300-0152.2717","volume":"48","author":"FN Sinan","year":"2024","unstructured":"Sinan FN, Serdaro\u011flu Ka\u015fik\u00e7i E, \u00c7evreli B. Chelidonic acid abrogates oxidative stress and memory dysfunction in experimental aging rats. Turk J Biol. 2024;48(6):432-41. https:\/\/doi.org\/10.55730\/1300-0152.2717","journal-title":"Turk J Biol."},{"issue":"2","key":"6749_CR5","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1134\/S0036023624603076","volume":"70","author":"SV Kozin","year":"2025","unstructured":"Kozin SV, Kravtsov AA, Kindop VK, et al. Synthesis and physicochemical properties of magnesium salts of 4H-pyrancarboxylic acids. Russ J Inorg Chem. 2025;70(2):169- 78. https:\/\/doi.org\/10.1134\/S0036023624603076","journal-title":"Russ J Inorg Chem."},{"issue":"8","key":"6749_CR6","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1134\/s0006297910080134","volume":"75","author":"EV Stelmashook","year":"2010","unstructured":"Stelmashook EV, Novikova SV, Isaev NK. Glutamine effect on cultured granule neuron death induced by glucose deprivation and chemical hypoxia. Biochemistry (Mosc). 2010;75(8):1039-44. https:\/\/doi.org\/10.1134\/s0006297910080134","journal-title":"Biochemistry (Mosc)."},{"key":"6749_CR7","doi-asserted-by":"crossref","unstructured":"Andreeva NA, Stel\u2019mashuk EV, Isaev NK, et al. Neuroprotective properties of nootropic dipeptide GVS-111 in in vitro oxygen-glucose deprivation, glutamate toxicity and oxidative stress. Bull Exp Biol Med. 2000;130(10):969-72.","DOI":"10.1023\/A:1002828707337"},{"issue":"5","key":"6749_CR8","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s10517-021-05281-6","volume":"171","author":"SV Kozin","year":"2021","unstructured":"Kozin SV, Kravtsov AA, Kravchenko SV, et al. Cytoprotective and antioxidant effects of meconic acid in model systems. Bull Exp Biol Med. 2021;171(5):619-22. https:\/\/doi.org\/10.1007\/s10517-021-05281-6","journal-title":"Bull Exp Biol Med."},{"issue":"9","key":"6749_CR9","doi-asserted-by":"publisher","first-page":"8046","DOI":"10.3390\/ijms24098046","volume":"24","author":"S Kozin","year":"2023","unstructured":"Kozin S, Kravtsov A, Ivashchenko L, et al. Study of the magnesium comenate structure, its neuroprotective and stress-protective activity. Int J Mol Sci. 2023;24(9):8046. https:\/\/doi.org\/10.3390\/ijms24098046","journal-title":"Int J Mol Sci."},{"issue":"6","key":"6749_CR10","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1002\/jnr.22295","volume":"88","author":"T Brustovetsky","year":"2010","unstructured":"Brustovetsky T, Bolshakov A, Brustovetsky N. Calpain activation and Na+\/Ca2+ exchanger degradation occur downstream of calcium deregulation in hippocampal neurons exposed to excitotoxic glutamate. J Neurosci Res. 2010;88(6):1317-28. https:\/\/doi.org\/10.1002\/jnr.22295","journal-title":"J Neurosci Res."},{"issue":"1","key":"6749_CR11","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1684\/mrh.2019.0454","volume":"32","author":"V Romeo","year":"2019","unstructured":"Romeo V, Cazzaniga A, Maier JAM. Magnesium and the blood-brain barrier in vitro: effects on permeability and magnesium transport. Magnes Res. 2019;32(1):16-24. https:\/\/doi.org\/10.1684\/mrh.2019.0454","journal-title":"Magnes Res."},{"issue":"1","key":"6749_CR12","doi-asserted-by":"publisher","first-page":"223","DOI":"10.3390\/ijms24010223","volume":"24","author":"JAM Maier","year":"2022","unstructured":"Maier JAM, Locatelli L, Fedele G, et al. Magnesium and the brain: A focus on neuroinflammation and neurodegeneration. Int J Mol Sci. 2022;24(1):223. https:\/\/doi.org\/10.3390\/ijms24010223","journal-title":"Int J Mol Sci."},{"issue":"4","key":"6749_CR13","first-page":"483","volume":"60","author":"E Poleszak","year":"2008","unstructured":"Poleszak E. Benzodiazepine\/GABA(A) receptors are involved in magnesium-induced anxiolytic-like behavior in mice. Pharmacol Rep. 2008;60(4):483-9.","journal-title":"Pharmacol Rep."},{"issue":"4","key":"6749_CR14","doi-asserted-by":"publisher","first-page":"4435","DOI":"10.1007\/s00210-024-03550-5","volume":"398","author":"SI Khairnar","year":"2025","unstructured":"Khairnar SI, Kulkarni YA, Singh K. Neuroprotective effect of chelidonic acid through oxidative stress reduction in paclitaxel-induced peripheral neuropathy in rats. Naunyn Schmiedebergs Arch Pharmacol. 2025;398(4):4435-47. https:\/\/doi.org\/10.1007\/s00210-024-03550-5","journal-title":"Naunyn Schmiedebergs Arch Pharmacol."},{"issue":"14","key":"6749_CR15","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1177\/1535370216642044","volume":"241","author":"HJ Jeong","year":"2016","unstructured":"Jeong HJ, Yang SY, Kim HY, et al. Chelidonic acid evokes antidepressant-like effect through the up-regulation of BDNF in forced swimming test. Exp Biol Med (Maywood). 2016;241(14):1559-67. https:\/\/doi.org\/10.1177\/1535370216642044","journal-title":"Exp Biol Med (Maywood)."}],"container-title":["Bulletin of Experimental Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-026-06749-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10517-026-06749-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10517-026-06749-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:03:36Z","timestamp":1793300616000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10517-026-06749-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["6749"],"URL":"https:\/\/doi.org\/10.1007\/s10517-026-06749-z","relation":{},"ISSN":["0007-4888","1573-8221"],"issn-type":[{"value":"0007-4888","type":"print"},{"value":"1573-8221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"25 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}