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We examined the effects of teenage exposure to parental smoking on substance use and externalizing outcomes in an adoption study. In total, 1232 offspring from 617 families were longitudinally assessed at mean ages of 15, 18, 22, and 32 years, with 37% of offspring living with at least one smoking parent at the intake assessment. We tested the effect of this exposure on offspring tobacco and cannabis use; nicotine, alcohol, and drug dependence; and ADHD, oppositional defiant disorder, conduct disorder, and adult antisocial behavior at all available follow-up assessments. Effect sizes in adoptive offspring were generally small for all outcomes, indicating minimal environmental effects from exposure to parental smoking. In contrast, the effects of exposure were stronger across all outcomes for biological (nonadopted) offspring, though not uniformly significantly statistically stronger. The environmental risk of parental smoking appears specific to offspring tobacco use while the genetic risk is more general across externalizing outcomes, consistent with Keyes et al. (2008)\u2019s original findings from the initial intake assessment of this cohort.<\/jats:p>","DOI":"10.1007\/s10519-026-10278-w","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:39:24Z","timestamp":1784104764000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Growing Up with Parents Who Smoke: Genetic and Environmental Effects on Offspring Substance Use and Externalizing Psychopathology From a 20-Year Minnesota Study of Adoptive Families"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2581-5439","authenticated-orcid":false,"given":"Kathryn P.","family":"O\u2019Donnell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Huizenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Herman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Willoughby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Krueger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylia","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn I.","family":"Roisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Luciana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Iacono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Malone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3861-7930","authenticated-orcid":false,"given":"Scott","family":"Vrieze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"issue":"14","key":"10278_CR1","first-page":"381","volume":"64","author":"RA Arrazola","year":"2015","unstructured":"Arrazola RA, Singh T, Corey CG, Husten CG, Neff LJ, Apelberg BJ, Bunnell RE, Choiniere CJ, King BA, Cox S, McAfee T, Caraballo RS, Centers for Disease Control and Prevention (CDC) (2015) Tobacco use among middle and high school students - United States, 2011\u20132014. 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