{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:32:22Z","timestamp":1786980742079,"version":"build-2736575974"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2010,5,9]],"date-time":"2010-05-09T00:00:00Z","timestamp":1273363200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biogerontology"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1007\/s10522-010-9281-8","type":"journal-article","created":{"date-parts":[[2010,5,7]],"date-time":"2010-05-07T18:31:41Z","timestamp":1273257101000},"page":"627-633","source":"Crossref","is-referenced-by-count":45,"title":["Peripheral inflammatory biomarkers of Alzheimer\u2019s disease: the role of platelets"],"prefix":"10.1007","volume":"11","author":[{"given":"Tiziana","family":"Casoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Di Stefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Balietti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moreno","family":"Solazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Giorgetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Fattoretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,5,9]]},"reference":[{"key":"9281_CR1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","volume":"21","author":"H Akiyama","year":"2000","unstructured":"Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O\u2019Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T (2000) Inflammation and Alzheimer\u2019s disease. Neurobiol Aging 21:383\u2013421","journal-title":"Neurobiol Aging"},{"key":"9281_CR2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.imlet.2008.02.002","volume":"117","author":"P Bermejo","year":"2008","unstructured":"Bermejo P, Mart\u00edn-Arag\u00f3n S, Bened\u00ed J, Sus\u00edn C, Felici E, Gil P, Ribera JM, Villar AM (2008) Differences of peripheral inflammatory markers between mild cognitive impairment and Alzheimer\u2019s disease. Immunol Lett 117:198\u2013202","journal-title":"Immunol Lett"},{"key":"9281_CR3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jneuroim.2007.10.020","volume":"193","author":"K Bonotis","year":"2008","unstructured":"Bonotis K, Krikki E, Holeva V, Aggouridaki C, Costa V, Baloyannis S (2008) Systemic immune aberrations in Alzheimer\u2019s disease patients. J Neuroimmunol 193:183\u2013187","journal-title":"J Neuroimmunol"},{"key":"9281_CR4","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1007\/s00415-005-0867-z","volume":"252","author":"B Borroni","year":"2005","unstructured":"Borroni B, Perani D, Broli M, Colciaghi F, Garibotto V, Paghera B, Agosti C, Giubbini R, Di Luca M, Padovani A (2005) Pre-clinical diagnosis of Alzheimer disease combining platelet amyloid precursor protein ratio and rCBF spect analysis. J Neurol 252:1359\u20131362","journal-title":"J Neurol"},{"key":"9281_CR5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.exger.2009.08.004","volume":"45","author":"B Borroni","year":"2010","unstructured":"Borroni B, Agosti C, Marcello E, Di Luca M, Padovani A (2010) Blood cell markers in Alzheimer disease: amyloid precursor protein form ratio in platelets. Exp Gerontol 45:53\u201356","journal-title":"Exp Gerontol"},{"key":"9281_CR6","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.mad.2007.11.004","volume":"129","author":"T Casoli","year":"2008","unstructured":"Casoli T, Di Stefano G, Giorgetti B, Balietti M, Recchioni R, Moroni F, Marcheselli F, Bernardini G, Fattoretti P, Bertoni-Freddari C (2008) Platelet as a physiological model to investigate apoptotic mechanisms in Alzheimer beta-amyloid peptide production. Mech Ageing Dev 129:154\u2013162","journal-title":"Mech Ageing Dev"},{"key":"9281_CR7","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/bbrc.1995.2103","volume":"213","author":"M Chen","year":"1995","unstructured":"Chen M, Inestrosa NC, Ross GS, Fernandez HL (1995) Platelets are the primary source of amyloid beta-peptide in human blood. Biochem Biophys Res Commun 213:96\u2013103","journal-title":"Biochem Biophys Res Commun"},{"key":"9281_CR8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s11064-005-2676-2","volume":"30","author":"A Cupello","year":"2005","unstructured":"Cupello A, Favale E, Audenino D, Scarrone S, Gastaldi S, Albano C (2005) Decrease of serotonin transporters in blood platelets after epileptic seizures. Neurochem Res 30:425\u2013428","journal-title":"Neurochem Res"},{"key":"9281_CR9","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/S0047-6374(01)00313-X","volume":"122","author":"A Luigi De","year":"2001","unstructured":"De Luigi A, Fragiacomo C, Lucca U, Quadri P, Tettamanti M, Grazia De Simoni M (2001) Inflammatory markers in Alzheimer\u2019s disease and multi-infarct dementia. Mech Ageing Dev 122:1985\u20131995","journal-title":"Mech Ageing Dev"},{"key":"9281_CR10","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1084\/jem.20041497","volume":"201","author":"I Del Conde","year":"2005","unstructured":"Del Conde I, Cr\u00faz MA, Zhang H, L\u00f3pez JA, Afshar-Kharghan V (2005) Platelet activation leads to activation and propagation of the complement system. J Exp Med 201:871\u2013879","journal-title":"J Exp Med"},{"key":"9281_CR11","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1046\/j.1365-2362.2002.00994.x","volume":"32","author":"M Fiala","year":"2002","unstructured":"Fiala M, Liu QN, Sayre J, Pop V, Brahmandam V, Graves MC, Vinters HV (2002) Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer\u2019s disease brain and damage the blood-brain barrier. Eur J Clin Invest 32:360\u2013371","journal-title":"Eur J Clin Invest"},{"key":"9281_CR12","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/ana.10531","volume":"53","author":"D Galimberti","year":"2003","unstructured":"Galimberti D, Schoonenboom N, Scarpini E, Scheltens P, Dutch-Italian Alzheimer research Group (2003) Chemokines in serum and cerebrospinal fluid of Alzheimer\u2019s disease patients. Ann Neurol 53:547\u2013548","journal-title":"Ann Neurol"},{"key":"9281_CR13","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00702-004-0142-y","volume":"111","author":"WF Gattaz","year":"2004","unstructured":"Gattaz WF, Forlenza OV, Talib LL, Barbosa NR, Bottino CM (2004) Platelet phospholipase A(2) activity in Alzheimer\u2019s disease and mild cognitive impairment. J Neural Transm 111:591\u2013601","journal-title":"J Neural Transm"},{"key":"9281_CR14","doi-asserted-by":"crossref","first-page":"C1772","DOI":"10.1152\/ajpcell.2000.279.6.C1772","volume":"279","author":"R Giri","year":"2000","unstructured":"Giri R, Shen Y, Stins M, Du Yan S, Schmidt AM, Stern D, Kim KS, Zlokovic B, Kalra VK (2000) Beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1. Am J Physiol Cell Physiol 279:C1772\u2013C1781","journal-title":"Am J Physiol Cell Physiol"},{"key":"9281_CR15","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1182\/blood-2002-09-2797","volume":"101","author":"DV Gnatenko","year":"2003","unstructured":"Gnatenko DV, Dunn JJ, McCorkle SR, Weissmann D, Perrotta PL, Bahou WF (2003) Transcript profiling of human platelets using microarray and serial analysis of gene expression. Blood 101:2285\u20132293","journal-title":"Blood"},{"key":"9281_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1440-1681.2000.03200.x","volume":"27","author":"G Halliday","year":"2000","unstructured":"Halliday G, Robinson SR, Shepherd C, Kril J (2000) Alzheimer\u2019s disease and inflammation: a review of cellular and therapeutic mechanisms. Clin Exp Pharmacol Physiol 27:1\u20138","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"9281_CR17","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.exger.2005.04.007","volume":"40","author":"C Iarlori","year":"2005","unstructured":"Iarlori C, Gambi D, Gambi F, Lucci I, Feliciani C, Salvatore M, Reale M (2005) Expression and production of two selected beta-chemokines in peripheral blood mononuclear cells from patients with Alzheimer\u2019s disease. Exp Gerontol 40:605\u2013611","journal-title":"Exp Gerontol"},{"key":"9281_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s004290050075","volume":"196","author":"MH Klinger","year":"1997","unstructured":"Klinger MH (1997) Platelets and inflammation. Anat Embryol (Berl) 196:1\u201311","journal-title":"Anat Embryol (Berl)"},{"key":"9281_CR19","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00702-007-0669-9","volume":"114","author":"E Krzystanek","year":"2007","unstructured":"Krzystanek E, Krzystanek M, Opala G, Trzeciak HI, Siuda J, Ma\u0142ecki A (2007) Platelet phospholipase A2 activity in patients with Alzheimer\u2019s disease, vascular dementia and ischemic stroke. J Neural Transm 114:1033\u20131039","journal-title":"J Neural Transm"},{"key":"9281_CR20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.imlet.2008.09.004","volume":"121","author":"KS Lee","year":"2008","unstructured":"Lee KS, Chung JH, Lee KH, Shin MJ, Oh BH, Hong CH (2008) Bioplex analysis of plasma cytokines in Alzheimer\u2019s disease and mild cognitive impairment. Immunol Lett 121:105\u2013109","journal-title":"Immunol Lett"},{"key":"9281_CR21","first-page":"461","volume":"78","author":"QX Li","year":"1998","unstructured":"Li QX, Whyte S, Tanner JE, Evin G, Beyreuther K, Masters CL (1998) Secretion of Alzheimer\u2019s disease Abeta amyloid peptide by activated human platelets. Lab Invest 78:461\u2013469","journal-title":"Lab Invest"},{"key":"9281_CR22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0165-5728(99)00226-X","volume":"103","author":"F Licastro","year":"2000","unstructured":"Licastro F, Pedrini S, Caputo L, Annoni G, Davis LJ, Ferri C, Casadei V, Grimaldi LM (2000) Increased plasma levels of interleukin-1, interleukin-6 and alpha-1-antichymotrypsin in patients with Alzheimer\u2019s disease: peripheral inflammation or signals from the brain? J Neuroimmunol 103:97\u2013102","journal-title":"J Neuroimmunol"},{"key":"9281_CR23","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1212\/WNL.47.2.425","volume":"47","author":"PL McGeer","year":"1996","unstructured":"McGeer PL, Schulzer M, McGeer EG (1996) Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer\u2019s disease: a review of 17 epidemiologic studies. Neurology 47:425\u2013432","journal-title":"Neurology"},{"key":"9281_CR24","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1160\/TH09-05-0289","volume":"102","author":"IC Munnix","year":"2009","unstructured":"Munnix IC, Cosemans JM, Auger JM, Heemskerk JW (2009) Platelet response heterogeneity in thrombus formation. Thromb Haemost 102:1149\u20131156","journal-title":"Thromb Haemost"},{"key":"9281_CR25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0006-8993(03)02361-8","volume":"971","author":"RG Nagele","year":"2003","unstructured":"Nagele RG, D\u2019Andrea MR, Lee H, Venkataraman V, Wang HY (2003) Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains. Brain Res 971:197\u2013209","journal-title":"Brain Res"},{"key":"9281_CR26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.nbd.2006.11.011","volume":"26","author":"HM Nielsen","year":"2007","unstructured":"Nielsen HM, Londos E, Minthon L, Janciauskiene SM (2007) Soluble adhesion molecules and angiotensin-converting enzyme in dementia. Neurobiol Dis 26:27\u201335","journal-title":"Neurobiol Dis"},{"key":"9281_CR27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.brainresrev.2009.05.007","volume":"61","author":"T Nuutinen","year":"2009","unstructured":"Nuutinen T, Suuronen T, Kauppinen A, Salminen A (2009) Clusterin: a forgotten player in Alzheimer\u2019s disease. Brain Res Rev 61:89\u2013104","journal-title":"Brain Res Rev"},{"key":"9281_CR28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/WAD.0b013e31811ec11f","volume":"21","author":"CI Prodan","year":"2007","unstructured":"Prodan CI, Ross ED, Vincent AS, Dale GL (2007) Coated-platelets are higher in amnestic versus nonamnestic patients with mild cognitive impairment. Alzheimer Dis Assoc Disord 21:259\u2013261","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"9281_CR29","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/WAD.0b013e318199dd1a","volume":"23","author":"CI Prodan","year":"2009","unstructured":"Prodan CI, Ross ED, Vincent AS, Dale GL (2009) Differences in coated-platelet production between frontotemporal dementia and Alzheimer disease. Alzheimer Dis Assoc Disord 23:234\u2013237","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"9281_CR30","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.molbrainres.2005.08.013","volume":"141","author":"S Rainesalo","year":"2005","unstructured":"Rainesalo S, Keranen T, Saransaari P, Honkaniemi J (2005) GABA and glutamate transporters are expressed in human platelets. Brain Res Mol Brain Res 141:161\u2013165","journal-title":"Brain Res Mol Brain Res"},{"key":"9281_CR31","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1001\/archneur.55.4.530","volume":"55","author":"S Sevush","year":"1998","unstructured":"Sevush S, Jy W, Horstman LL, Mao WW, Kolodny L, Ahn YS (1998) Platelet activation in Alzheimer disease. Arch Neurol 55:530\u2013536","journal-title":"Arch Neurol"},{"key":"9281_CR32","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1007\/s11064-008-9588-x","volume":"33","author":"C Sihlbom","year":"2008","unstructured":"Sihlbom C, Davidsson P, Sj\u00f6gren M, Wahlund LO, Nilsson CL (2008) Structural and quantitative comparison of cerebrospinal fluid glycoproteins in Alzheimer\u2019s disease patients and healthy individuals. Neurochem Res 33:1332\u20131340","journal-title":"Neurochem Res"},{"key":"9281_CR33","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1046\/j.1471-4159.2001.00121.x","volume":"76","author":"DK Song","year":"2001","unstructured":"Song DK, Im YB, Jung JS, Cho J, Suh HW, Kim YH (2001) Central beta-amyloid peptide-induced peripheral interleukin-6 responses in mice. J Neurochem 76:1326\u20131335","journal-title":"J Neurochem"},{"key":"9281_CR34","first-page":"107","volume":"807","author":"Z Suo","year":"1998","unstructured":"Suo Z, Tan J, Placzek A, Crawford F, Fang C, Mullan M (1998) Alzheimer\u2019s beta-amyloid peptides induce inflammatory cascade in human vascular cells: the roles of cytokines and CD40. Brain Res 807:107\u2013110","journal-title":"Brain Res"},{"key":"9281_CR35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.blre.2006.06.001","volume":"21","author":"A Zarbock","year":"2007","unstructured":"Zarbock A, Polanowska-Grabowska RK, Ley K (2007) Platelet-neutrophil-interactions: linking hemostasis and inflammation. Blood Rev 21:99\u2013111","journal-title":"Blood Rev"}],"container-title":["Biogerontology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-010-9281-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10522-010-9281-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-010-9281-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T15:46:03Z","timestamp":1559144763000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10522-010-9281-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,9]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["9281"],"URL":"https:\/\/doi.org\/10.1007\/s10522-010-9281-8","relation":{},"ISSN":["1389-5729","1573-6768"],"issn-type":[{"value":"1389-5729","type":"print"},{"value":"1573-6768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,9]]}}}