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The purpose of this study was to assess the combined effects of progressive resistance training (PRT) and protein supplementation beyond habitual intakes on upper leg lean tissue mass (LTM), muscle quality and functional capability in healthy 50\u201370\u00a0years women. In a single-blinded, randomized, controlled design, 57 healthy older women (age 61.1\u00a0\u00b1\u00a05.1\u00a0years, 1.61\u00a0\u00b1\u00a00.65\u00a0m, 65.3\u00a0\u00b1\u00a015.3\u00a0kg) consumed 0.33\u00a0g\/kg body mass of a milk-based protein matrix (PRO) for 12\u00a0weeks. Of the 57 women, 29 also engaged in a PRT intervention (PRO\u00a0+\u00a0PRT). In comparison to the PRO group (n\u00a0=\u00a028), those in the PRO\u00a0+\u00a0PRT group had an increase in upper leg LTM [0.04 (95% CI \u22120.07 to 0.01) kg vs. 0.13 (95% CI 0.08\u20130.18) kg,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.027], as measured by Dual-energy X-ray absorptiometry; an increase in knee extensor (KE) torque [\u22121.6 (95% CI \u22127.3 to 4.4\u00a0N\u00a0m) vs. 10.2 (95% CI 4.3\u201315.8\u00a0N\u00a0m),\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.007], as measured from a maximal voluntary isometric contraction (Con-Trex MJ; CMV AG); and an increase in extended gait speed [-0.01 (95% CI \u22120.52\u20130.04) m\u00a0s\n                    <jats:sup>\u22121<\/jats:sup>\n                    vs. 0.10 (95% CI 0.05\u20130.22) m\u00a0s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.001] as measured from a maximal 900\u2009m effort. There was no difference between groups in the time taken to complete 5 chair rises or the number of chair rises performed in 30\u00a0s (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&gt;\u00a00.05). PRT in healthy older women ingesting a dietary protein supplement is an effective strategy to improve upper leg LTM, KE torque and extended gait speed in healthy older women.\n                  <\/jats:p>","DOI":"10.1007\/s10522-016-9671-7","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T01:24:24Z","timestamp":1481160264000},"page":"881-891","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Twelve weeks\u2019 progressive resistance training combined with protein supplementation beyond habitual intakes increases upper leg lean tissue mass, muscle strength and extended gait speed in healthy older women"],"prefix":"10.1007","volume":"18","clinical-trial-number":[{"clinical-trial-number":"nct02529124","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9720-6253","authenticated-orcid":false,"given":"Peter","family":"Francis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Mc Cormack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clodagh","family":"Toomey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Norton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmet","family":"Kerin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Jakeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,8]]},"reference":[{"key":"9671_CR1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1123\/ijsnem.16.4.362","volume":"16","author":"RD Andrews","year":"2006","unstructured":"Andrews RD, MacLean DA, Riechman SE (2006) Protein intake for skeletal muscle hypertrophy with resistance training in seniors. 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