{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:26:58Z","timestamp":1792783618410,"version":"4.5.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Neurosciences research center of Tabriz University of Medical Sciences","award":["grant number:63881"],"award-info":[{"award-number":["grant number:63881"]}],"id":[{"id":"https:\/\/ror.org\/04krpx645","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Neurosciences research center of Tabriz University of Medical Sciences","award":["grant number:63881"],"award-info":[{"award-number":["grant number:63881"]}],"id":[{"id":"https:\/\/ror.org\/04krpx645","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Neurosciences research center of Tabriz University of Medical Sciences","award":["grant number:63881"],"award-info":[{"award-number":["grant number:63881"]}],"id":[{"id":"https:\/\/ror.org\/04krpx645","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Neurosciences research center of Tabriz University of Medical Sciences","award":["grant number:63881"],"award-info":[{"award-number":["grant number:63881"]}],"id":[{"id":"https:\/\/ror.org\/04krpx645","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Neurosciences research center of Tabriz University of Medical Sciences","award":["grant number:63881"],"award-info":[{"award-number":["grant number:63881"]}],"id":[{"id":"https:\/\/ror.org\/04krpx645","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biogerontology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s10522-022-10014-x","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T04:04:06Z","timestamp":1673323446000},"page":"257-273","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["RETRACTED ARTICLE: Mitotherapy restores hippocampal mitochondrial function and cognitive impairment in aged male rats subjected to chronic mild stress"],"prefix":"10.1007","volume":"24","author":[{"given":"Gonja","family":"Javani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Babri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Farajdokht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshad","family":"Ghaffari-Nasab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisou","family":"Mohaddes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"10014_CR1","doi-asserted-by":"publisher","first-page":"3109","DOI":"10.7150\/THNO.53474","volume":"11","author":"JF Alexander","year":"2021","unstructured":"Alexander JF, Seua AV, Arroyo LD et al (2021) Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits. Theranostics 11:3109\u20133130. https:\/\/doi.org\/10.7150\/THNO.53474","journal-title":"Theranostics"},{"key":"10014_CR2","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00109-013-1046-9","volume":"91","author":"M Amaral","year":"2013","unstructured":"Amaral M, Outeiro TF, Scrutton NS, Giorgini F (2013) The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease. J Mol Med 91:705\u2013713. https:\/\/doi.org\/10.1007\/s00109-013-1046-9","journal-title":"J Mol Med"},{"key":"10014_CR3","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","volume":"13","author":"M Antunes","year":"2012","unstructured":"Antunes M, Biala G (2012) The novel object recognition memory: Neurobiology, test procedure, and its modifications. Cogn Process 13:93\u2013110. https:\/\/doi.org\/10.1007\/s10339-011-0430-z","journal-title":"Cogn Process"},{"key":"10014_CR4","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.3389\/fcell.2021.683459","volume":"9","author":"S Azam","year":"2021","unstructured":"Azam S, Haque ME, Balakrishnan R et al (2021) The ageing brain: molecular and cellular basis of neurodegeneration. Front Cell Dev Biol 9:2120. https:\/\/doi.org\/10.3389\/fcell.2021.683459","journal-title":"Front Cell Dev Biol"},{"key":"10014_CR5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.brainres.2019.03.020","volume":"1715","author":"A Banagozar Mohammadi","year":"2019","unstructured":"Banagozar Mohammadi A, Torbati M, Farajdokht F et al (2019) Sericin alleviates restraint stress induced depressive- and anxiety-like behaviors via modulation of oxidative stress, neuroinflammation and apoptosis in the prefrontal cortex and hippocampus. Brain Res 1715:47\u201356. https:\/\/doi.org\/10.1016\/j.brainres.2019.03.020","journal-title":"Brain Res"},{"key":"10014_CR6","doi-asserted-by":"publisher","first-page":"610","DOI":"10.2174\/1570159x14666160229114755","volume":"14","author":"Y Bansal","year":"2016","unstructured":"Bansal Y, Kuhad A (2016) Mitochondrial dysfunction in depression. Curr Neuropharmacol 14:610\u2013618. https:\/\/doi.org\/10.2174\/1570159x14666160229114755","journal-title":"Curr Neuropharmacol"},{"key":"10014_CR7","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jneumeth.2015.09.033","volume":"265","author":"Z Bayram-Weston","year":"2016","unstructured":"Bayram-Weston Z, Olsen E, Harrison DJ et al (2016) Optimising Golgi-Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington\u2019s disease. J Neurosci Methods 265:81\u201388. https:\/\/doi.org\/10.1016\/j.jneumeth.2015.09.033","journal-title":"J Neurosci Methods"},{"key":"10014_CR8","doi-asserted-by":"publisher","first-page":"6737","DOI":"10.3390\/ijms22136737","volume":"22","author":"T Behl","year":"2021","unstructured":"Behl T, Kaur I, Sehgal A et al (2021) The footprint of kynurenine pathway in neurodegeneration: janus-faced role in parkinson\u2019s disorder and therapeutic implications. Int J Mol Sci 22:6737. https:\/\/doi.org\/10.3390\/ijms22136737","journal-title":"Int J Mol Sci"},{"key":"10014_CR9","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.neubiorev.2017.04.030","volume":"79","author":"LEB Bettio","year":"2017","unstructured":"Bettio LEB, Rajendran L, Gil-Mohapel J (2017) The effects of aging in the hippocampus and cognitive decline. Neurosci Biobehav Rev 79:66\u201386.\u00a0https:\/\/doi.org\/10.1016\/j.neubiorev.2017.04.030","journal-title":"Neurosci Biobehav Rev"},{"key":"10014_CR10","doi-asserted-by":"publisher","DOI":"10.1177\/15353702211056866","author":"NV Bobkova","year":"2021","unstructured":"Bobkova NV, Zhdanova DY, Belosludtseva NV et al (2021) Intranasal administration of mitochondria improves spatial memory in olfactory bulbectomized mice. Exp Biol Med. https:\/\/doi.org\/10.1177\/15353702211056866","journal-title":"Exp Biol Med"},{"key":"10014_CR11","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1046\/j.1471-4159.1997.69041629.x","volume":"69","author":"YM Bordelon","year":"1997","unstructured":"Bordelon YM, Chesselet MF, Nelson D et al (1997) Energetic dysfunction in quinolinic acid-lesioned rat striatum. J Neurochem 69:1629\u20131639. https:\/\/doi.org\/10.1046\/j.1471-4159.1997.69041629.x","journal-title":"J Neurochem"},{"key":"10014_CR12","doi-asserted-by":"publisher","first-page":"3499","DOI":"10.1590\/1413-812320152111.17452015","volume":"21","author":"JCC Cabral","year":"2016","unstructured":"Cabral JCC, Veleda GW, Mazzoleni M et al (2016) Estresse e Reserva Cognitiva como determinantes independentes para o desempenho neuropsicol\u00f3gico de idosos saud\u00e1veis. Cienc e Saude Coletiva 21:3499\u20133508. https:\/\/doi.org\/10.1590\/1413-812320152111.17452015","journal-title":"Cienc e Saude Coletiva"},{"key":"10014_CR13","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7610414","author":"A Caicedo","year":"2017","unstructured":"Caicedo A, Aponte PM, Cabrera F et al (2017) Artificial mitochondria transfer: current challenges, advances, and future applications. Stem Cells Int. https:\/\/doi.org\/10.1155\/2017\/7610414","journal-title":"Stem Cells Int"},{"key":"10014_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.749737","author":"M Carrier","year":"2021","unstructured":"Carrier M, \u0160imon\u010di\u010dov\u00e1 E, St-Pierre MK et al (2021) Psychological stress as a risk factor for accelerated cellular aging and cognitive decline: the involvement of microglia-neuron crosstalk. Front Mol Neurosci. https:\/\/doi.org\/10.3389\/fnmol.2021.749737","journal-title":"Front Mol Neurosci"},{"key":"10014_CR15","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.neuroscience.2012.05.002","volume":"219","author":"R Chavez-Valdez","year":"2012","unstructured":"Chavez-Valdez R, Martin LJ, Flock DL, Northington FJ (2012) Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia-ischemia. Neuroscience 219:192\u2013203. https:\/\/doi.org\/10.1016\/j.neuroscience.2012.05.002","journal-title":"Neuroscience"},{"key":"10014_CR16","doi-asserted-by":"publisher","unstructured":"Chistiakov DA, Sobenin IA, Revin VV et al (2014) Mitochondrial aging and age-related dysfunction of mitochondria. Biomed Res Int 238463. https:\/\/doi.org\/10.1155\/2014\/238463","DOI":"10.1155\/2014\/238463"},{"issue":"Suppl 1","key":"10014_CR17","doi-asserted-by":"publisher","first-page":"i111","DOI":"10.1093\/geronb\/gbr019","volume":"66","author":"HC Comijs","year":"2011","unstructured":"Comijs HC, van den Kommer TN, Minnaar RWM et al (2011) Accumulated and differential effects of life events on cognitive decline in older persons: depending on depression, baseline cognition, or ApoE epsilon4 status? J Gerontol B Psychol Sci Soc Sci 66(Suppl 1):i111\u2013i120. https:\/\/doi.org\/10.1093\/geronb\/gbr019","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"10014_CR18","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/nrn.2017.170","volume":"19","author":"MJ Devine","year":"2018","unstructured":"Devine MJ, Kittler JT (2018) Mitochondria at the neuronal presynapse in health and disease. Nat Rev Neurosci 19:63\u201380. https:\/\/doi.org\/10.1038\/nrn.2017.170","journal-title":"Nat Rev Neurosci"},{"key":"10014_CR19","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.neuroscience.2012.09.077","volume":"251","author":"DL Dickstein","year":"2013","unstructured":"Dickstein DL, Weaver CM, Luebke JI, Hof PR (2013) Dendritic spine changes associated with normal aging. Neuroscience 251:21\u201332. https:\/\/doi.org\/10.1016\/j.neuroscience.2012.09.077","journal-title":"Neuroscience"},{"key":"10014_CR20","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1093\/cercor\/bhg081","volume":"13","author":"I Driscoll","year":"2003","unstructured":"Driscoll I, Hamilton DA, Petropoulos H et al (2003) The aging hippocampus: cognitive, biochemical and structural findings. Cereb Cortex 13:1344\u20131351. https:\/\/doi.org\/10.1093\/cercor\/bhg081","journal-title":"Cereb Cortex"},{"key":"10014_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134304","author":"S Fallahi","year":"2019","unstructured":"Fallahi S, Babri S, Farajdokht F et al (2019) Neuroprotective effect of ghrelin in methamphetamine-treated male rats. Neurosci Lett. https:\/\/doi.org\/10.1016\/j.neulet.2019.134304","journal-title":"Neurosci Lett"},{"key":"10014_CR22","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.neuron.2019.04.013","volume":"102","author":"A Fernandez","year":"2019","unstructured":"Fernandez A, Meechan DW, Karpinski BA et al (2019) Mitochondrial dysfunction leads to cortical under-connectivity and cognitive impairment. Neuron 102:1127\u20131142e3. https:\/\/doi.org\/10.1016\/j.neuron.2019.04.013","journal-title":"Neuron"},{"key":"10014_CR23","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1113\/EP089415","volume":"106","author":"A Ghaffari-Nasab","year":"2021","unstructured":"Ghaffari-Nasab A, Badalzadeh R, Mohaddes G, Alipour MR (2021) Young plasma administration mitigates depression-like behaviours in chronic mild stress-exposed aged rats by attenuating apoptosis in prefrontal cortex. Exp Physiol 106:1621\u20131630. https:\/\/doi.org\/10.1113\/EP089415","journal-title":"Exp Physiol"},{"key":"10014_CR24","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1007\/s11064-021-03440-9","volume":"47","author":"A Ghaffari-Nasab","year":"2022","unstructured":"Ghaffari-Nasab A, Badalzadeh R, Mohaddes G et al (2022) Young plasma induces antidepressant-like Effects in aged rats subjected to chronic mild stress by suppressing Indoleamine 2,3-Dioxygenase enzyme and kynurenine pathway in the Prefrontal Cortex. Neurochem Res 47:358\u2013371. https:\/\/doi.org\/10.1007\/s11064-021-03440-9","journal-title":"Neurochem Res"},{"key":"10014_CR25","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.neulet.2010.11.006","volume":"488","author":"Y Gong","year":"2011","unstructured":"Gong Y, Chai Y, Ding JH et al (2011) Chronic mild stress damages mitochondrial ultrastructure and function in mouse brain. Neurosci Lett 488:76\u201380. https:\/\/doi.org\/10.1016\/j.neulet.2010.11.006","journal-title":"Neurosci Lett"},{"key":"10014_CR26","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.bbi.2015.06.022","volume":"50","author":"JM Heisler","year":"2015","unstructured":"Heisler JM, O\u2019Connor JC (2015) Indoleamine 2,3-dioxygenase-dependent neurotoxic kynurenine metabolism mediates inflammation-induced deficit in recognition memory. Brain Behav Immun 50:115\u2013124. https:\/\/doi.org\/10.1016\/j.bbi.2015.06.022","journal-title":"Brain Behav Immun"},{"key":"10014_CR27","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.bbr.2015.07.011","volume":"292","author":"V Hidalgo","year":"2015","unstructured":"Hidalgo V, Pulopulos MM, Puig-Perez S et al (2015) Acute stress affects free recall and recognition of pictures differently depending on age and sex. Behav Brain Res 292:393\u2013402. https:\/\/doi.org\/10.1016\/j.bbr.2015.07.011","journal-title":"Behav Brain Res"},{"key":"10014_CR28","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neuroscience.2019.09.037","volume":"423","author":"L Hosseini","year":"2019","unstructured":"Hosseini L, Farokhi-Sisakht F, Badalzadeh R et al (2019) Nicotinamide mononucleotide and melatonin alleviate aging-induced cognitive impairment via modulation of mitochondrial function and apoptosis in the Prefrontal Cortex and Hippocampus. Neuroscience 423:29\u201337. https:\/\/doi.org\/10.1016\/j.neuroscience.2019.09.037","journal-title":"Neuroscience"},{"key":"10014_CR29","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.psychres.2005.11.011","volume":"145","author":"J Jaeger","year":"2006","unstructured":"Jaeger J, Berns S, Uzelac S, Davis-Conway S (2006) Neurocognitive deficits and disability in major depressive disorder. Psychiatry Res 145:39\u201348. https:\/\/doi.org\/10.1016\/j.psychres.2005.11.011","journal-title":"Psychiatry Res"},{"key":"10014_CR30","doi-asserted-by":"publisher","first-page":"111632","DOI":"10.1016\/j.mad.2022.111632","volume":"202","author":"G Javani","year":"2022","unstructured":"Javani G, Babri S, Farajdokht F et al (2022) Mitochondrial transplantation improves anxiety- and depression-like behaviors in aged stress-exposed rats. Mech Ageing Dev 202:111632. https:\/\/doi.org\/10.1016\/j.mad.2022.111632","journal-title":"Mech Ageing Dev"},{"key":"10014_CR31","doi-asserted-by":"publisher","first-page":"4118","DOI":"10.1093\/emboj\/18.15.4118","volume":"18","author":"G Kaim","year":"1999","unstructured":"Kaim G, Dimroth P (1999) ATP synthesis by F-type ATP synthase is obligatorily dependent on the transmembrane voltage. EMBO J 18:4118\u20134127. https:\/\/doi.org\/10.1093\/emboj\/18.15.4118","journal-title":"EMBO J"},{"key":"10014_CR32","doi-asserted-by":"publisher","first-page":"019","DOI":"10.17352\/2455-5460.000004","volume":"1","author":"Y Kambe","year":"2015","unstructured":"Kambe Y (2015) Potential involvement of mitochondrial dysfunction in major depressive disorder: recent evidence. Arch Depress Anxiety 1:019\u2013028. https:\/\/doi.org\/10.17352\/2455-5460.000004","journal-title":"Arch Depress Anxiety"},{"key":"10014_CR33","doi-asserted-by":"publisher","first-page":"3327","DOI":"10.1093\/hmg\/ddx217","volume":"26","author":"M Khacho","year":"2017","unstructured":"Khacho M, Clark A, Svoboda DS et al (2017) Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis. Hum Mol Genet 26:3327\u20133341. https:\/\/doi.org\/10.1093\/hmg\/ddx217","journal-title":"Hum Mol Genet"},{"key":"10014_CR34","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1101\/lm.037291.114","volume":"22","author":"EJ Kim","year":"2015","unstructured":"Kim EJ, Pellman B, Kim JJ (2015) Stress effects on the hippocampus: a critical review. Learn Mem 22:411\u2013416. https:\/\/doi.org\/10.1101\/lm.037291.114","journal-title":"Learn Mem"},{"key":"10014_CR35","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/j.biopsych.2010.01.025","volume":"67","author":"AJG Knoops","year":"2010","unstructured":"Knoops AJG, Gerritsen L, van der Graaf Y et al (2010) Basal hypothalamic pituitary adrenal Axis activity and hippocampal volumes: the SMART-Medea Study. Biol Psychiatry 67:1191\u20131198. https:\/\/doi.org\/10.1016\/j.biopsych.2010.01.025","journal-title":"Biol Psychiatry"},{"key":"10014_CR36","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1080\/10253890.2021.1959546","volume":"24","author":"D La Torre","year":"2021","unstructured":"La Torre D, Dalile B, de Loor H et al (2021) Changes in kynurenine pathway metabolites after acute psychosocial stress in healthy males: a single-arm pilot study. Stress 24:920\u2013930. https:\/\/doi.org\/10.1080\/10253890.2021.1959546","journal-title":"Stress"},{"key":"10014_CR37","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1097\/WNR.0b013e328332bb09","volume":"20","author":"T Lee","year":"2009","unstructured":"Lee T, Jarome T, Li SJ et al (2009) Chronic stress selectively reduces hippocampal volume in rats: a longitudinal magnetic resonance imaging study. NeuroReport 20:1554\u20131558. https:\/\/doi.org\/10.1097\/WNR.0b013e328332bb09","journal-title":"NeuroReport"},{"key":"10014_CR38","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1042\/CS20200530","volume":"134","author":"H Ma","year":"2020","unstructured":"Ma H, Jiang T, Tang W et al (2020) Transplantation of platelet-derived mitochondria alleviates cognitive impairment and mitochondrial dysfunction in db\/db mice. Clin Sci 134:2161\u20132175. https:\/\/doi.org\/10.1042\/CS20200530","journal-title":"Clin Sci"},{"key":"10014_CR39","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1100\/tsw.2010.48","volume":"10","author":"N Maggio","year":"2010","unstructured":"Maggio N, Segal M (2010) Corticosteroid regulation of synaptic plasticity in the hippocampus. ScientificWorldJournal 10:462\u2013469. https:\/\/doi.org\/10.1100\/tsw.2010.48","journal-title":"ScientificWorldJournal"},{"key":"10014_CR40","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1038\/nn.4086","volume":"18","author":"BS McEwen","year":"2015","unstructured":"McEwen BS, Bowles NP, Gray JD et al (2015) Mechanisms of stress in the brain. Nat Neurosci 18:1353\u20131363. https:\/\/doi.org\/10.1038\/nn.4086","journal-title":"Nat Neurosci"},{"key":"10014_CR41","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1080\/15622975.2018.1468031","volume":"20","author":"A Messaoud","year":"2019","unstructured":"Messaoud A, Mensi R, Douki W et al (2019) Reduced peripheral availability of tryptophan and increased activation of the kynurenine pathway and cortisol correlate with major depression and suicide. World J Biol Psychiatry 20:703\u2013711. https:\/\/doi.org\/10.1080\/15622975.2018.1468031","journal-title":"World J Biol Psychiatry"},{"key":"10014_CR42","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.3390\/cells10071603","volume":"10","author":"A Mor","year":"2021","unstructured":"Mor A, Tankiewicz-Kwedlo A, Krupa A, Pawlak D (2021) Role of kynurenine pathway in oxidative stress during neurodegenerative disorders. Cells 10:1603. https:\/\/doi.org\/10.3390\/cells10071603","journal-title":"Cells"},{"key":"10014_CR43","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.3390\/cells10071827","volume":"10","author":"G Nascimento-Dos-santos","year":"2021","unstructured":"Nascimento-Dos-santos G, De-Souza-ferreira E, Linden R et al (2021) Mitotherapy: unraveling a promising treatment for disorders of the central nervous system and other systemic conditions. Cells 10:1827. https:\/\/doi.org\/10.3390\/cells10071827","journal-title":"Cells"},{"key":"10014_CR44","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/j.1474-9728.2003.00079.x","volume":"3","author":"DG Nicholls","year":"2004","unstructured":"Nicholls DG (2004) Mitochondrial membrane potential and aging. Aging Cell 3:35\u201340. https:\/\/doi.org\/10.1111\/j.1474-9728.2003.00079.x","journal-title":"Aging Cell"},{"key":"10014_CR45","doi-asserted-by":"publisher","first-page":"587","DOI":"10.3233\/JAD-190853","volume":"72","author":"K Nitzan","year":"2019","unstructured":"Nitzan K, Benhamron S, Valitsky M et al (2019) Mitochondrial transfer ameliorates cognitive deficits, neuronal loss, and gliosis in Alzheimer\u2019s Disease mice. J Alzheimers Dis 72:587\u2013604. https:\/\/doi.org\/10.3233\/JAD-190853","journal-title":"J Alzheimers Dis"},{"key":"10014_CR46","doi-asserted-by":"publisher","first-page":"101558","DOI":"10.1016\/j.redox.2020.101558","volume":"34","author":"MA Olesen","year":"2020","unstructured":"Olesen MA, Torres AK, Jara C et al (2020) Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss. Redox Biol 34:101558. https:\/\/doi.org\/10.1016\/j.redox.2020.101558","journal-title":"Redox Biol"},{"key":"10014_CR47","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094793","author":"A Park","year":"2021","unstructured":"Park A, Oh M, Lee SJ et al (2021) Mitochondrial transplantation as a novel therapeutic strategy for mitochondrial diseases. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms22094793","journal-title":"Int J Mol Sci"},{"key":"10014_CR48","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.tins.2014.11.001","volume":"38","author":"JA Prenderville","year":"2015","unstructured":"Prenderville JA, Kennedy PJ, Dinan TG, Cryan JF (2015) Adding fuel to the fire: the impact of stress on the ageing brain. Trends Neurosci 38:13\u201325. https:\/\/doi.org\/10.1016\/j.tins.2014.11.001","journal-title":"Trends Neurosci"},{"key":"10014_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fncel.2019.00074","volume":"13","author":"F Salehpour","year":"2019","unstructured":"Salehpour F, Farajdokht F, Mahmoudi J et al (2019) Photobiomodulation and coenzyme Q10 treatments attenuate cognitive impairment associated with model of transient global brain ischemia in artificially aged mice. Front Cell Neurosci 13:1\u201317. https:\/\/doi.org\/10.3389\/fncel.2019.00074","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"10014_CR50","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3390\/molecules23010191","volume":"23","author":"K Sas","year":"2018","unstructured":"Sas K, Szab\u00f3 E, V\u00e9csei L (2018) Mitochondria, oxidative stress and the kynurenine system, with a focus on ageing and neuroprotection. Molecules 23(1):191","journal-title":"Molecules"},{"key":"10014_CR51","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/789710","author":"A Schloesser","year":"2015","unstructured":"Schloesser A, Esatbeyoglu T, Piegholdt S et al (2015) Dietary tocotrienol\/\u03b3-cyclodextrin complex increases mitochondrial membrane potential and ATP concentrations in the brains of aged mice. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2015\/789710","journal-title":"Oxid Med Cell Longev"},{"key":"10014_CR52","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1001\/archgenpsychiatry.2010.48","volume":"67","author":"A Soetanto","year":"2010","unstructured":"Soetanto A, Wilson RS, Talbot K et al (2010) Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans. Arch Gen Psychiatry 67:448\u2013457. https:\/\/doi.org\/10.1001\/archgenpsychiatry.2010.48","journal-title":"Arch Gen Psychiatry"},{"key":"10014_CR53","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.pbb.2006.01.004","volume":"83","author":"L Song","year":"2006","unstructured":"Song L, Che W, Min-wei W et al (2006) Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress. Pharmacol Biochem Behav 83:186\u2013193. https:\/\/doi.org\/10.1016\/j.pbb.2006.01.004","journal-title":"Pharmacol Biochem Behav"},{"key":"10014_CR54","doi-asserted-by":"publisher","first-page":"117864692097265","DOI":"10.1177\/1178646920972657","volume":"13","author":"FJH Sorgdrager","year":"2020","unstructured":"Sorgdrager FJH, van Der Ley CP, van Faassen M et al (2020) The effect of tryptophan 2,3-dioxygenase inhibition on kynurenine metabolism and cognitive function in the APP23 mouse model of Alzheimer\u2019s Disease. Int J Tryptophan Res 13:1178646920972657. https:\/\/doi.org\/10.1177\/1178646920972657","journal-title":"Int J Tryptophan Res"},{"key":"10014_CR55","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/S0306-4522(00)00465-6","volume":"101","author":"N Sousa","year":"2000","unstructured":"Sousa N, Lukoyanov NV, Madeira MD et al (2000) Erratum: reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement (Neurosicience 97:2 (253\u2013266) PII: S0306452200000506). Neuroscience 101:483. https:\/\/doi.org\/10.1016\/S0306-4522(00)00465-6","journal-title":"Neuroscience"},{"key":"10014_CR56","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1111\/bph.12230","volume":"169","author":"TW Stone","year":"2013","unstructured":"Stone TW, Darlington LG (2013) The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders. Br J Pharmacol 169:1211\u20131227. https:\/\/doi.org\/10.1111\/bph.12230","journal-title":"Br J Pharmacol"},{"key":"10014_CR57","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1159\/000046886","volume":"10","author":"MM Sugrue","year":"2001","unstructured":"Sugrue MM, Tatton WG (2001) Mitochondrial membrane potential in aging cells. Neurosignals 10:176\u2013188. https:\/\/doi.org\/10.1159\/000046886","journal-title":"Neurosignals"},{"key":"10014_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-60607-0","volume":"10","author":"R Sussams","year":"2020","unstructured":"Sussams R, Schlotz W, Clough Z et al (2020) Psychological stress, cognitive decline and the development of dementia in amnestic mild cognitive impairment. Sci Rep 10:1\u201311. https:\/\/doi.org\/10.1038\/s41598-020-60607-0","journal-title":"Sci Rep"},{"key":"10014_CR59","doi-asserted-by":"publisher","first-page":"166","DOI":"10.2174\/1570159x14666160414111821","volume":"15","author":"V Todorova","year":"2016","unstructured":"Todorova V, Blokland A (2016) Mitochondria and synaptic plasticity in the mature and aging nervous system. Curr Neuropharmacol 15:166\u2013173. https:\/\/doi.org\/10.2174\/1570159x14666160414111821","journal-title":"Curr Neuropharmacol"},{"key":"10014_CR60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10522-022-09978-7","volume":"16","author":"E Tomtheelnganbee","year":"2022","unstructured":"Tomtheelnganbee E, Sah P, Sharma R (2022) Mitochondrial function and nutrient sensing pathways in ageing: enhancing longevity through dietary interventions. Biogerontology 16:1\u201324. https:\/\/doi.org\/10.1007\/s10522-022-09978-7","journal-title":"Biogerontology"},{"key":"10014_CR64","doi-asserted-by":"publisher","unstructured":"Wang Y, Ni J, Gao C et al (2019) Mitochondrial transplantation attenuates lipopolysaccharide-induced depression-like behaviors. Prog Neuropsychopharmacol Biol Psychiatry 93:240\u2013249. https:\/\/doi.org\/10.1016\/j.pnpbp.2019.04.010","DOI":"10.1016\/j.pnpbp.2019.04.010"},{"key":"10014_CR61","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.freeradbiomed.2016.04.200","volume":"100","author":"F Yin","year":"2016","unstructured":"Yin F, Sancheti H, Patil I, Cadenas E (2016) Energy metabolism and inflammation in brain aging and Alzheimer\u2019s disease. Free Radic Biol Med 100:108\u2013122. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2016.04.200","journal-title":"Free Radic Biol Med"},{"key":"10014_CR62","doi-asserted-by":"publisher","first-page":"849","DOI":"10.7150\/ijbs.40886","volume":"16","author":"Z Zhao","year":"2020","unstructured":"Zhao Z, Yu Z, Hou Y et al (2020) Improvement of cognitive and motor performance with mitotherapy in aged mice. Int J Biol Sci 16:849\u2013858. https:\/\/doi.org\/10.7150\/ijbs.40886","journal-title":"Int J Biol Sci"},{"key":"10014_CR63","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.trsl.2021.03.017","volume":"235","author":"J Zhao","year":"2021","unstructured":"Zhao J, Qu D, Xi Z et al (2021) Mitochondria transplantation protects traumatic brain injury via promoting neuronal survival and astrocytic BDNF. Transl Res 235:102\u2013114. https:\/\/doi.org\/10.1016\/j.trsl.2021.03.017","journal-title":"Transl Res"}],"updated-by":[{"DOI":"10.1007\/s10522-026-10398-0","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000}}],"container-title":["Biogerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-022-10014-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10522-022-10014-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-022-10014-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:37:48Z","timestamp":1769834268000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10522-022-10014-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,10]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10014"],"URL":"https:\/\/doi.org\/10.1007\/s10522-022-10014-x","relation":{},"ISSN":["1389-5729","1573-6768"],"issn-type":[{"value":"1389-5729","type":"print"},{"value":"1573-6768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,10]]},"assertion":[{"value":"30 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article has been retracted. Please see the Retraction Notice for more detail:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s10522-026-10398-0","URL":"https:\/\/doi.org\/10.1007\/s10522-026-10398-0","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no\ncompeting interests to declare that are relevant to the content of this\narticle.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}