{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:10:36Z","timestamp":1791288636617,"version":"4.3.0"},"reference-count":176,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2022\/006612"],"award-info":[{"award-number":["CRG\/2022\/006612"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Manipal Academy of Higher Education - Kasturba Medical College, Mangalore"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biogerontology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The gut microbiota (GM) produces various molecules that regulate the physiological functionality of the brain through the gut-brain axis (GBA). Studies suggest that alteration in GBA may lead to the onset and progression of various neurological dysfunctions. Moreover, aging is one of the prominent causes that contribute to the alteration of GBA. With age, GM undergoes a shift in population size and species of microflora leading to changes in their secreted metabolites. These changes also hamper communications among the HPA (hypothalamic\u2013pituitary\u2013adrenal), ENS (enteric nervous system), and ANS (autonomic nervous system). A therapeutic intervention that has recently gained attention in improving health and maintaining communication between the gut and the brain is calorie restriction (CR), which also plays a critical role in autophagy and neurogenesis processes. However, its strict regime and lifelong commitment pose challenges. The need is to produce similar beneficial effects of CR without having its rigorous compliance. This led to an exploration of calorie restriction mimetics (CRMs) which could mimic CR\u2019s functions without limiting diet, providing long-term health benefits. CRMs ensure the efficient functioning of the GBA through gut bacteria and their metabolites i.e., short-chain fatty acids, bile acids, and neurotransmitters. This is particularly beneficial for elderly individuals, as the GM deteriorates with age and the body\u2019s ability to digest the toxic accumulates declines. In this review, we have explored the beneficial effect of CRMs in extending lifespan by enhancing the beneficial bacteria and their effects on metabolite production, physiological conditions, and neurological dysfunctions including neurodegenerative disorders.<\/jats:p>","DOI":"10.1007\/s10522-024-10128-4","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T18:45:29Z","timestamp":1724438729000},"page":"899-922","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders"],"prefix":"10.1007","volume":"25","author":[{"given":"Ishika","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepashree J.","family":"Gowda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitha","family":"Kamath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3186-9898","authenticated-orcid":false,"given":"Abhishek Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"10128_CR1","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1111\/fcp.12689","volume":"35","author":"F Aghaie","year":"2021","unstructured":"Aghaie F, Moradifar F, Hosseini A (2021) Rapamycin attenuates depression and anxiety-like behaviors through modulation of the NLRP3 pathway in pentylenetetrazole-kindled male Wistar rats. Fundam Clin Pharmacol 35:1045\u20131054. https:\/\/doi.org\/10.1111\/fcp.12689","journal-title":"Fundam Clin Pharmacol"},{"key":"10128_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.612078","author":"S Ahmad","year":"2021","unstructured":"Ahmad S, Khan A, Ali W et al (2021) Fisetin rescues the mice brains against D-galactose-induced oxidative stress, neuroinflammation and memory impairment. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2021.612078","journal-title":"Front Pharmacol"},{"key":"10128_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.neures.2023.01.010","volume":"192","author":"F Ahmad","year":"2023","unstructured":"Ahmad F, Javed M, Athar M, Shahzadi S (2023) Determination of affected brain regions at various stages of Alzheimer\u2019s disease. Neurosci Res 192:77\u201382. https:\/\/doi.org\/10.1016\/j.neures.2023.01.010","journal-title":"Neurosci Res"},{"key":"10128_CR4","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.1093\/gerona\/glaa056","volume":"75","author":"S Ahmadi","year":"2020","unstructured":"Ahmadi S, Razazan A, Nagpal R et al (2020) Metformin reduces aging-related leaky gut and improves cognitive function by beneficially modulating gut microbiome\/goblet cell\/mucin axis. J Gerontol A Biol Sci Med Sci 75:e9\u2013e21. https:\/\/doi.org\/10.1093\/gerona\/glaa056","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10128_CR5","doi-asserted-by":"publisher","first-page":"G328","DOI":"10.1152\/ajpgi.00203.2013","volume":"306","author":"M Al-Qudah","year":"2014","unstructured":"Al-Qudah M, Anderson CD, Mahavadi S et al (2014) Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C. Am J Physiol Gastrointest Liver Physiol 306:G328-337. https:\/\/doi.org\/10.1152\/ajpgi.00203.2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10128_CR6","doi-asserted-by":"publisher","first-page":"57591","DOI":"10.1007\/s11356-022-19876-7","volume":"29","author":"AS Alshehri","year":"2022","unstructured":"Alshehri AS, El-Kott AF, El-Kenawy AE et al (2022) The ameliorative effect of kaempferol against CdCl2- mediated renal damage entails activation of Nrf2 and inhibition of NF-kB. Environ Sci Pollut Res Int 29:57591\u201357602. https:\/\/doi.org\/10.1007\/s11356-022-19876-7","journal-title":"Environ Sci Pollut Res Int"},{"key":"10128_CR7","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/acel.12527","volume":"16","author":"I Amigo","year":"2017","unstructured":"Amigo I, Menezes-Filho SL, Lu\u00e9vano-Mart\u00ednez LA et al (2017) Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity. Aging Cell 16:73\u201381. https:\/\/doi.org\/10.1111\/acel.12527","journal-title":"Aging Cell"},{"key":"10128_CR8","doi-asserted-by":"publisher","first-page":"5981","DOI":"10.1111\/febs.12335","volume":"280","author":"PMA Antony","year":"2013","unstructured":"Antony PMA, Diederich NJ, Kr\u00fcger R, Balling R (2013) The hallmarks of Parkinson\u2019s disease. FEBS J 280:5981\u20135993. https:\/\/doi.org\/10.1111\/febs.12335","journal-title":"FEBS J"},{"key":"10128_CR9","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.bcp.2017.06.116","volume":"141","author":"DM Apple","year":"2017","unstructured":"Apple DM, Solano-Fonseca R, Kokovay E (2017) Neurogenesis in the aging brain. Biochem Pharmacol 141:77\u201385. https:\/\/doi.org\/10.1016\/j.bcp.2017.06.116","journal-title":"Biochem Pharmacol"},{"key":"10128_CR10","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1089\/rej.2022.0032","volume":"26","author":"JK Arya","year":"2023","unstructured":"Arya JK, Kumar R, Singh A et al (2023) Acarbose, an \u03b1-glucosidase inhibitor, maintains altered redox homeostasis during aging by targeting glucose metabolism in rat erythrocytes. Rejuvenation Res 26:21\u201331. https:\/\/doi.org\/10.1089\/rej.2022.0032","journal-title":"Rejuvenation Res"},{"key":"10128_CR11","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10522-023-10055-w","volume":"24","author":"MC Atayik","year":"2023","unstructured":"Atayik MC, \u00c7akatay U (2023) Redox signaling and modulation in ageing. Biogerontology 24:603\u2013608. https:\/\/doi.org\/10.1007\/s10522-023-10055-w","journal-title":"Biogerontology"},{"key":"10128_CR12","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1139\/apnm-2017-0648","volume":"43","author":"S Athari Nik Azm","year":"2018","unstructured":"Athari Nik Azm S, Djazayeri A, Safa M et al (2018) Lactobacilli and bifidobacteria ameliorate memory and learning deficits and oxidative stress in \u03b2-amyloid (1\u201342) injected rats. Appl Physiol Nutr Metab 43:718\u2013726. https:\/\/doi.org\/10.1139\/apnm-2017-0648","journal-title":"Appl Physiol Nutr Metab"},{"key":"10128_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.114201","volume":"438","author":"F Baghaei Naeini","year":"2023","unstructured":"Baghaei Naeini F, Hassanpour S, Asghari A (2023) Resveratrol exerts anxiolytic-like effects through anti-inflammatory and antioxidant activities in rats exposed to chronic social isolation. Behav Brain Res 438:114201. https:\/\/doi.org\/10.1016\/j.bbr.2022.114201","journal-title":"Behav Brain Res"},{"key":"10128_CR14","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1007\/s00125-017-4318-z","volume":"60","author":"CJ Bailey","year":"2017","unstructured":"Bailey CJ (2017) Metformin: historical overview. Diabetologia 60:1566\u20131576. https:\/\/doi.org\/10.1007\/s00125-017-4318-z","journal-title":"Diabetologia"},{"key":"10128_CR15","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1111\/j.1572-0241.2005.00230.x","volume":"100","author":"G Barbara","year":"2005","unstructured":"Barbara G, Stanghellini V, Brandi G et al (2005) Interactions between commensal bacteria and gut sensorimotor function in health and disease. Am J Gastroenterol 100:2560\u20132568. https:\/\/doi.org\/10.1111\/j.1572-0241.2005.00230.x","journal-title":"Am J Gastroenterol"},{"key":"10128_CR16","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13024-016-0082-7","volume":"11","author":"E Barini","year":"2016","unstructured":"Barini E, Antico O, Zhao Y et al (2016) Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy. Mol Neurodegener 11:16. https:\/\/doi.org\/10.1186\/s13024-016-0082-7","journal-title":"Mol Neurodegener"},{"key":"10128_CR17","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1007\/s10495-020-01625-1","volume":"25","author":"MD Baroni","year":"2020","unstructured":"Baroni MD, Colombo S, Libens O et al (2020) In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase. Apoptosis 25:686\u2013696. https:\/\/doi.org\/10.1007\/s10495-020-01625-1","journal-title":"Apoptosis"},{"key":"10128_CR18","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature05354","volume":"444","author":"JA Baur","year":"2006","unstructured":"Baur JA, Pearson KJ, Price NL et al (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444:337\u2013342. https:\/\/doi.org\/10.1038\/nature05354","journal-title":"Nature"},{"key":"10128_CR19","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.neulet.2007.01.010","volume":"415","author":"BS Beltz","year":"2007","unstructured":"Beltz BS, Tlusty MF, Benton JL, Sandeman DC (2007) Omega-3 fatty acids upregulate adult neurogenesis. Neurosci Lett 415:154\u2013158. https:\/\/doi.org\/10.1016\/j.neulet.2007.01.010","journal-title":"Neurosci Lett"},{"key":"10128_CR20","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/joim.12611","volume":"282","author":"B Bonaz","year":"2017","unstructured":"Bonaz B, Sinniger V, Pellissier S (2017) Vagus nerve stimulation: a new promising therapeutic tool in inflammatory bowel disease. J Intern Med 282:46\u201363. https:\/\/doi.org\/10.1111\/joim.12611","journal-title":"J Intern Med"},{"key":"10128_CR21","doi-asserted-by":"publisher","DOI":"10.1007\/s10123-024-00518-6","author":"A Borrego-Ruiz","year":"2024","unstructured":"Borrego-Ruiz A, Borrego JJ (2024) Human gut microbiome, diet, and mental disorders. Int Microbiol. https:\/\/doi.org\/10.1007\/s10123-024-00518-6","journal-title":"Int Microbiol"},{"key":"10128_CR22","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/s41398-020-00908-0","volume":"10","author":"A Borsini","year":"2020","unstructured":"Borsini A, Stangl D, Jeffries AR et al (2020) The role of omega-3 fatty acids in preventing glucocorticoid-induced reduction in human hippocampal neurogenesis and increase in apoptosis. Transl Psychiatry 10:219. https:\/\/doi.org\/10.1038\/s41398-020-00908-0","journal-title":"Transl Psychiatry"},{"key":"10128_CR23","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.cell.2013.02.035","volume":"153","author":"F Cabreiro","year":"2013","unstructured":"Cabreiro F, Au C, Leung K-Y et al (2013) Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell 153:228\u2013239. https:\/\/doi.org\/10.1016\/j.cell.2013.02.035","journal-title":"Cell"},{"key":"10128_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108238","volume":"237","author":"J Cai","year":"2022","unstructured":"Cai J, Rimal B, Jiang C et al (2022) Bile acid metabolism and signaling, the microbiota, and metabolic disease. Pharmacol Ther 237:108238. https:\/\/doi.org\/10.1016\/j.pharmthera.2022.108238","journal-title":"Pharmacol Ther"},{"key":"10128_CR25","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.cmet.2010.02.006","volume":"11","author":"C Cant\u00f3","year":"2010","unstructured":"Cant\u00f3 C, Jiang LQ, Deshmukh AS et al (2010) Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab 11:213\u2013219. https:\/\/doi.org\/10.1016\/j.cmet.2010.02.006","journal-title":"Cell Metab"},{"key":"10128_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-018-0126-x","volume":"50","author":"C Chelakkot","year":"2018","unstructured":"Chelakkot C, Ghim J, Ryu SH (2018) Mechanisms regulating intestinal barrier integrity and its pathological implications. Exp Mol Med 50:1\u20139. https:\/\/doi.org\/10.1038\/s12276-018-0126-x","journal-title":"Exp Mol Med"},{"key":"10128_CR27","doi-asserted-by":"publisher","first-page":"e02210","DOI":"10.1128\/mBio.02210-15","volume":"7","author":"M Chen","year":"2016","unstructured":"Chen M, Yi L, Zhang Y et al (2016) Resveratrol attenuates trimethylamine-N-oxide (TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut microbiota. Mbio 7:e02210-02215. https:\/\/doi.org\/10.1128\/mBio.02210-15","journal-title":"Mbio"},{"key":"10128_CR28","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.3390\/nu13062099","volume":"13","author":"Y Chen","year":"2021","unstructured":"Chen Y, Xu J, Chen Y (2021a) Regulation of neurotransmitters by the gut microbiota and effects on cognition in neurological disorders. Nutrients 13:2099. https:\/\/doi.org\/10.3390\/nu13062099","journal-title":"Nutrients"},{"key":"10128_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.625913","author":"Y Chen","year":"2021","unstructured":"Chen Y, Zhou J, Wang L (2021b) Role and mechanism of gut microbiota in human disease. Front Cell Infect Microbiol. https:\/\/doi.org\/10.3389\/fcimb.2021.625913","journal-title":"Front Cell Infect Microbiol"},{"key":"10128_CR30","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.yexcr.2016.08.013","volume":"347","author":"M-C Chiang","year":"2016","unstructured":"Chiang M-C, Cheng Y-C, Chen S-J et al (2016) Metformin activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against Amyloid-beta-induced mitochondrial dysfunction. Exp Cell Res 347:322\u2013331. https:\/\/doi.org\/10.1016\/j.yexcr.2016.08.013","journal-title":"Exp Cell Res"},{"key":"10128_CR31","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jnutbio.2013.09.013","volume":"25","author":"S Chuengsamarn","year":"2014","unstructured":"Chuengsamarn S, Rattanamongkolgul S, Phonrat B et al (2014) Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial. J Nutr Biochem 25:144\u2013150. https:\/\/doi.org\/10.1016\/j.jnutbio.2013.09.013","journal-title":"J Nutr Biochem"},{"key":"10128_CR32","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/mp.2012.77","volume":"18","author":"G Clarke","year":"2013","unstructured":"Clarke G, Grenham S, Scully P et al (2013) The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry 18:666\u2013673. https:\/\/doi.org\/10.1038\/mp.2012.77","journal-title":"Mol Psychiatry"},{"key":"10128_CR33","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.neuron.2009.09.002","volume":"64","author":"BE Deverman","year":"2009","unstructured":"Deverman BE, Patterson PH (2009) Cytokines and CNS development. Neuron 64:61\u201378. https:\/\/doi.org\/10.1016\/j.neuron.2009.09.002","journal-title":"Neuron"},{"key":"10128_CR34","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1210\/en.2014-1354","volume":"156","author":"KV Doan","year":"2015","unstructured":"Doan KV, Ko CM, Kinyua AW et al (2015) Gallic acid regulates body weight and glucose homeostasis through AMPK activation. Endocrinology 156:157\u2013168. https:\/\/doi.org\/10.1210\/en.2014-1354","journal-title":"Endocrinology"},{"key":"10128_CR35","doi-asserted-by":"publisher","first-page":"6781872","DOI":"10.1155\/2017\/6781872","volume":"2017","author":"JL Espinoza","year":"2017","unstructured":"Espinoza JL, Trung LQ, Inaoka PT et al (2017) The repeated administration of resveratrol has measurable effects on circulating T-cell subsets in humans. Oxid Med Cell Longev 2017:6781872. https:\/\/doi.org\/10.1155\/2017\/6781872","journal-title":"Oxid Med Cell Longev"},{"key":"10128_CR36","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1093\/nutrit\/nuaa114","volume":"79","author":"JJA Ferguson","year":"2021","unstructured":"Ferguson JJA, Abbott KA, Garg ML (2021) Anti-inflammatory effects of oral supplementation with curcumin: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev 79:1043\u20131066. https:\/\/doi.org\/10.1093\/nutrit\/nuaa114","journal-title":"Nutr Rev"},{"key":"10128_CR37","doi-asserted-by":"publisher","first-page":"eabo2984","DOI":"10.1126\/scitranslmed.abo2984","volume":"15","author":"AL Ferreiro","year":"2023","unstructured":"Ferreiro AL, Choi J, Ryou J et al (2023) Gut microbiome composition may be an indicator of preclinical Alzheimer\u2019s disease. Sci Transl Med 15:eabo2984. https:\/\/doi.org\/10.1126\/scitranslmed.abo2984","journal-title":"Sci Transl Med"},{"key":"10128_CR38","doi-asserted-by":"publisher","first-page":"1115721","DOI":"10.3389\/fphar.2023.1115721","volume":"14","author":"AI Foudah","year":"2023","unstructured":"Foudah AI, Devi S, Alam A et al (2023) Anticholinergic effect of resveratrol with vitamin E on scopolamine-induced Alzheimer\u2019s disease in rats: Mechanistic approach to prevent inflammation. Front Pharmacol 14:1115721. https:\/\/doi.org\/10.3389\/fphar.2023.1115721","journal-title":"Front Pharmacol"},{"key":"10128_CR39","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.3390\/nu15092211","volume":"15","author":"W Fusco","year":"2023","unstructured":"Fusco W, Lorenzo MB, Cintoni M et al (2023) Short-chain fatty-acid-producing bacteria: key components of the human gut microbiota. Nutrients 15:2211. https:\/\/doi.org\/10.3390\/nu15092211","journal-title":"Nutrients"},{"key":"10128_CR40","doi-asserted-by":"publisher","first-page":"82","DOI":"10.3390\/cells9010082","volume":"9","author":"E Gaband\u00e9-Rodr\u00edguez","year":"2020","unstructured":"Gaband\u00e9-Rodr\u00edguez E, G\u00f3mez de las Heras MM, Mittelbrunn M (2020) Control of inflammation by calorie restriction mimetics: on the crossroad of autophagy and mitochondria. Cells 9:82. https:\/\/doi.org\/10.3390\/cells9010082","journal-title":"Cells"},{"key":"10128_CR41","doi-asserted-by":"publisher","first-page":"e57268","DOI":"10.15252\/embr.202357268","volume":"24","author":"R Gabarr\u00f3-Solanas","year":"2023","unstructured":"Gabarr\u00f3-Solanas R, Davaatseren A, Kleifeld J et al (2023) Adult neural stem cells and neurogenesis are resilient to intermittent fasting. EMBO Rep 24:e57268. https:\/\/doi.org\/10.15252\/embr.202357268","journal-title":"EMBO Rep"},{"key":"10128_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111847","volume":"141","author":"S Ghafouri-Fard","year":"2021","unstructured":"Ghafouri-Fard S, Shoorei H, Khanbabapour Sasi A et al (2021) The impact of the phytotherapeutic agent quercetin on expression of genes and activity of signaling pathways. Biomed Pharmacother 141:111847. https:\/\/doi.org\/10.1016\/j.biopha.2021.111847","journal-title":"Biomed Pharmacother"},{"key":"10128_CR43","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/path.2697","volume":"221","author":"D Glick","year":"2010","unstructured":"Glick D, Barth S, Macleod KF (2010) Autophagy: cellular and molecular mechanisms. J Pathol 221:3\u201312. https:\/\/doi.org\/10.1002\/path.2697","journal-title":"J Pathol"},{"key":"10128_CR44","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1111\/j.1749-6632.2009.04019.x","volume":"1170","author":"EL Greer","year":"2009","unstructured":"Greer EL, Banko MR, Brunet A (2009) AMP-activated protein kinase and FoxO transcription factors in dietary restriction-induced longevity. Ann NY Acad Sci 1170:688\u2013692. https:\/\/doi.org\/10.1111\/j.1749-6632.2009.04019.x","journal-title":"Ann NY Acad Sci"},{"key":"10128_CR45","doi-asserted-by":"publisher","first-page":"1992236","DOI":"10.1080\/19490976.2021.1992236","volume":"13","author":"A Gregor","year":"2021","unstructured":"Gregor A, Pignitter M, Trajanoski S et al (2021) Microbial contribution to the caloric restriction-triggered regulation of the intestinal levels of glutathione transferases, taurine, and bile acid. Gut Microbes 13:1992236. https:\/\/doi.org\/10.1080\/19490976.2021.1992236","journal-title":"Gut Microbes"},{"key":"10128_CR46","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.bbagen.2013.09.009","volume":"1840","author":"GA Gualdoni","year":"2014","unstructured":"Gualdoni GA, Kovarik JJ, Hofer J et al (2014) Resveratrol enhances TNF-\u03b1 production in human monocytes upon bacterial stimulation. Biochimica Et Biophysica Acta (BBA)\u2014Gen Subj 1840:95\u2013105","journal-title":"Biochimica Et Biophysica Acta (BBA)\u2014Gen Subj"},{"key":"10128_CR47","doi-asserted-by":"publisher","first-page":"3166","DOI":"10.3390\/nu13093166","volume":"13","author":"J Gudden","year":"2021","unstructured":"Gudden J, Arias Vasquez A, Bloemendaal M (2021) The effects of intermittent fasting on brain and cognitive function. Nutrients 13:3166. https:\/\/doi.org\/10.3390\/nu13093166","journal-title":"Nutrients"},{"key":"10128_CR48","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/0016-5085(89)91678-8","volume":"97","author":"M Gu\u00e9","year":"1989","unstructured":"Gu\u00e9 M, Peeters T, Depoortere I et al (1989) Stress-induced changes in gastric emptying, postprandial motility, and plasma gut hormone levels in dogs. Gastroenterology 97:1101\u20131107. https:\/\/doi.org\/10.1016\/0016-5085(89)91678-8","journal-title":"Gastroenterology"},{"key":"10128_CR49","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1016\/0016-5085(91)90270-u","volume":"100","author":"M Gue","year":"1991","unstructured":"Gue M, Junien JL, Bueno L (1991) Conditioned emotional response in rats enhances colonic motility through the central release of corticotropin-releasing factor. Gastroenterology 100:964\u2013970. https:\/\/doi.org\/10.1016\/0016-5085(91)90270-u","journal-title":"Gastroenterology"},{"key":"10128_CR50","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1046\/j.1471-4159.2001.00564.x","volume":"79","author":"Z Guo","year":"2001","unstructured":"Guo Z, Lee J, Lane M, Mattson MP (2001) Iodoacetate protects hippocampal neurons against excitotoxic and oxidative injury: involvement of heat-shock proteins and Bcl-2. J Neurochem 79:361\u2013370. https:\/\/doi.org\/10.1046\/j.1471-4159.2001.00564.x","journal-title":"J Neurochem"},{"key":"10128_CR51","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.nbd.2006.12.019","volume":"26","author":"VKM Halagappa","year":"2007","unstructured":"Halagappa VKM, Guo Z, Pearson M et al (2007) Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer\u2019s disease. Neurobiol Dis 26:212\u2013220. https:\/\/doi.org\/10.1016\/j.nbd.2006.12.019","journal-title":"Neurobiol Dis"},{"key":"10128_CR52","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1080\/07315724.2017.1392263","volume":"37","author":"M Hariri","year":"2018","unstructured":"Hariri M, Haghighatdoost F (2018) Effect of curcumin on anthropometric measures: a systematic review on randomized clinical trials. J Am Coll Nutr 37:215\u2013222. https:\/\/doi.org\/10.1080\/07315724.2017.1392263","journal-title":"J Am Coll Nutr"},{"key":"10128_CR53","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.7502","volume":"7","author":"N Hasan","year":"2019","unstructured":"Hasan N, Yang H (2019) Factors affecting the composition of the gut microbiota, and its modulation. PeerJ 7:e7502. https:\/\/doi.org\/10.7717\/peerj.7502","journal-title":"PeerJ"},{"key":"10128_CR54","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4201533","author":"B Hassani","year":"2022","unstructured":"Hassani B, Goshtasbi G, Nooraddini S, Firouzabadi N (2022) Pharmacological approaches to decelerate aging: a promising path. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2022\/4201533","journal-title":"Oxid Med Cell Longev"},{"key":"10128_CR55","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.1073\/pnas.1010529108","volume":"108","author":"RD Heijtz","year":"2011","unstructured":"Heijtz RD, Wang S, Anuar F et al (2011) Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci 108:3047\u20133052. https:\/\/doi.org\/10.1073\/pnas.1010529108","journal-title":"Proc Natl Acad Sci"},{"key":"10128_CR56","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0005-2760(80)90194-0","volume":"620","author":"GE Hoffmann","year":"1980","unstructured":"Hoffmann GE, Andres H, Weiss L et al (1980) Properties and organ distribution of ATP citrate (pro-3S)-lyase. Biochim Biophys Acta 620:151\u2013158. https:\/\/doi.org\/10.1016\/0005-2760(80)90194-0","journal-title":"Biochim Biophys Acta"},{"key":"10128_CR57","first-page":"339","volume-title":"Advances in protein chemistry and structural biology","author":"J Homolak","year":"2023","unstructured":"Homolak J (2023a) Chapter eleven\u2014targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics. In: \u00c7akatay U, Atayik MC (eds) Advances in protein chemistry and structural biology. Academic Press, Cambridge, pp 339\u2013383"},{"key":"10128_CR58","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s10522-023-10049-8","volume":"24","author":"J Homolak","year":"2023","unstructured":"Homolak J (2023b) Gastrointestinal redox homeostasis in ageing. Biogerontology 24:741\u2013752. https:\/\/doi.org\/10.1007\/s10522-023-10049-8","journal-title":"Biogerontology"},{"key":"10128_CR59","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.1021\/acschemneuro.3c00223","volume":"14","author":"J Homolak","year":"2023","unstructured":"Homolak J, De Busscher J, Zambrano-Lucio M et al (2023) Altered secretion, constitution, and functional properties of the gastrointestinal mucus in a rat model of sporadic Alzheimer\u2019s disease. ACS Chem Neurosci 14:2667\u20132682. https:\/\/doi.org\/10.1021\/acschemneuro.3c00223","journal-title":"ACS Chem Neurosci"},{"key":"10128_CR60","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/s41392-022-00974-4","volume":"7","author":"K Hou","year":"2022","unstructured":"Hou K, Wu Z-X, Chen X-Y et al (2022) Microbiota in health and diseases. Signal Transduct Target Ther 7:135. https:\/\/doi.org\/10.1038\/s41392-022-00974-4","journal-title":"Signal Transduct Target Ther"},{"key":"10128_CR61","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/nature01960","volume":"425","author":"KT Howitz","year":"2003","unstructured":"Howitz KT, Bitterman KJ, Cohen HY et al (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425:191\u2013196. https:\/\/doi.org\/10.1038\/nature01960","journal-title":"Nature"},{"key":"10128_CR62","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/2045-8118-10-32","volume":"10","author":"H Hsuchou","year":"2013","unstructured":"Hsuchou H, Pan W, Kastin AJ (2013) Fibroblast growth factor 19 entry into brain. Fluids Barriers CNS 10:32. https:\/\/doi.org\/10.1186\/2045-8118-10-32","journal-title":"Fluids Barriers CNS"},{"key":"10128_CR63","doi-asserted-by":"publisher","first-page":"H2273","DOI":"10.1111\/1750-3841.13411","volume":"81","author":"J Huang","year":"2016","unstructured":"Huang J, Chen L, Xue B et al (2016) Different flavonoids can shape unique gut microbiota profile in vitro. J Food Sci 81:H2273-2279. https:\/\/doi.org\/10.1111\/1750-3841.13411","journal-title":"J Food Sci"},{"key":"10128_CR64","doi-asserted-by":"publisher","first-page":"G368","DOI":"10.1152\/ajpgi.2001.280.3.G368","volume":"280","author":"E Husebye","year":"2001","unstructured":"Husebye E, Hellstr\u00f6m PM, Sundler F et al (2001) Influence of microbial species on small intestinal myoelectric activity and transit in germ-free rats. Am J Physiol Gastrointest Liver Physiol 280:G368-380. https:\/\/doi.org\/10.1152\/ajpgi.2001.280.3.G368","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10128_CR65","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.exger.2010.12.001","volume":"46","author":"DK Ingram","year":"2011","unstructured":"Ingram DK, Roth GS (2011) Glycolytic inhibition as a strategy for developing calorie restriction mimetics. Exp Gerontol 46:148\u2013154. https:\/\/doi.org\/10.1016\/j.exger.2010.12.001","journal-title":"Exp Gerontol"},{"key":"10128_CR66","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.arr.2014.11.005","volume":"20","author":"DK Ingram","year":"2015","unstructured":"Ingram DK, Roth GS (2015) Calorie restriction mimetics: can you have your cake and eat it, too? Ageing Res Rev 20:46\u201362. https:\/\/doi.org\/10.1016\/j.arr.2014.11.005","journal-title":"Ageing Res Rev"},{"key":"10128_CR67","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1515\/revneuro-2018-0084","volume":"30","author":"NK Isaev","year":"2019","unstructured":"Isaev NK, Stelmashook EV, Genrikhs EE (2019) Neurogenesis and brain aging. Rev Neurosci 30:573\u2013580. https:\/\/doi.org\/10.1515\/revneuro-2018-0084","journal-title":"Rev Neurosci"},{"key":"10128_CR68","doi-asserted-by":"publisher","first-page":"8787","DOI":"10.3748\/wjg.v21.i29.8787","volume":"21","author":"SM Jandhyala","year":"2015","unstructured":"Jandhyala SM, Talukdar R, Subramanyam C et al (2015) Role of the normal gut microbiota. World J Gastroenterol 21:8787\u20138803. https:\/\/doi.org\/10.3748\/wjg.v21.i29.8787","journal-title":"World J Gastroenterol"},{"key":"10128_CR69","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.freeradbiomed.2015.03.035","volume":"85","author":"L-L Ji","year":"2015","unstructured":"Ji L-L, Sheng Y-C, Zheng Z-Y et al (2015) The involvement of p62-Keap1-Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity. Free Radic Biol Med 85:12\u201323. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2015.03.035","journal-title":"Free Radic Biol Med"},{"key":"10128_CR70","doi-asserted-by":"publisher","first-page":"704","DOI":"10.3389\/fendo.2019.00704","volume":"10","author":"S Ji","year":"2019","unstructured":"Ji S, Wang L, Li L (2019) Effect of metformin on short-term high-fat diet-induced weight gain and anxiety-like behavior and the gut microbiota. Front Endocrinol 10:704. https:\/\/doi.org\/10.3389\/fendo.2019.00704","journal-title":"Front Endocrinol"},{"key":"10128_CR71","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.freeradbiomed.2016.10.495","volume":"105","author":"RM Jones","year":"2017","unstructured":"Jones RM, Neish AS (2017) Redox signaling mediated by the gut microbiota. Free Radical Biol Med 105:41\u201347. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2016.10.495","journal-title":"Free Radical Biol Med"},{"key":"10128_CR72","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/j.1365-2982.2005.00730.x","volume":"18","author":"MP Jones","year":"2006","unstructured":"Jones MP, Dilley JB, Drossman D, Crowell MD (2006) Brain-gut connections in functional GI disorders: anatomic and physiologic relationships. Neurogastroenterol Motil 18:91\u2013103. https:\/\/doi.org\/10.1111\/j.1365-2982.2005.00730.x","journal-title":"Neurogastroenterol Motil"},{"key":"10128_CR73","doi-asserted-by":"publisher","first-page":"543","DOI":"10.4103\/1673-5374.320970","volume":"17","author":"Y Ju","year":"2022","unstructured":"Ju Y, Tam KY (2022) Pathological mechanisms and therapeutic strategies for Alzheimer\u2019s disease. Neural Regen Res 17:543\u2013549. https:\/\/doi.org\/10.4103\/1673-5374.320970","journal-title":"Neural Regen Res"},{"key":"10128_CR74","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.2174\/0118715303275039231228065050","volume":"24","author":"FSH Kakhki","year":"2024","unstructured":"Kakhki FSH, Asghari A, Bardaghi Z et al (2024) The antidiabetic drug metformin attenuated depressive and anxietylike behaviors and oxidative stress in the brain in a rodent model of inflammation induced by lipopolysaccharide in male rats. Endocr Metabol Immun Disord\u2014Drug Targets 24:1525\u20131537. https:\/\/doi.org\/10.2174\/0118715303275039231228065050","journal-title":"Endocr Metabol Immun Disord\u2014Drug Targets"},{"key":"10128_CR75","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcp.2020.101672","volume":"54","author":"Y Kang","year":"2020","unstructured":"Kang Y, Sun Y, Li T, Ren Z (2020) Garcinol protects against cerebral ischemia-reperfusion injury in vivo and in vitro by inhibiting inflammation and oxidative stress. Mol Cell Probes 54:101672. https:\/\/doi.org\/10.1016\/j.mcp.2020.101672","journal-title":"Mol Cell Probes"},{"key":"10128_CR76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jnutbio.2016.10.013","volume":"43","author":"MP Kapoor","year":"2017","unstructured":"Kapoor MP, Sugita M, Fukuzawa Y, Okubo T (2017) Physiological effects of epigallocatechin-3-gallate (EGCG) on energy expenditure for prospective fat oxidation in humans: a systematic review and meta-analysis. J Nutr Biochem 43:1\u201310. https:\/\/doi.org\/10.1016\/j.jnutbio.2016.10.013","journal-title":"J Nutr Biochem"},{"key":"10128_CR77","doi-asserted-by":"publisher","first-page":"392","DOI":"10.3389\/fncel.2015.00392","volume":"9","author":"JR Kelly","year":"2015","unstructured":"Kelly JR, Kennedy PJ, Cryan JF et al (2015) Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders. Front Cell Neurosci 9:392. https:\/\/doi.org\/10.3389\/fncel.2015.00392","journal-title":"Front Cell Neurosci"},{"key":"10128_CR78","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1002\/ijc.26178","volume":"130","author":"N Khan","year":"2012","unstructured":"Khan N, Afaq F, Khusro FH et al (2012) Dual inhibition of pi3k\/akt and mtor signaling in human non-small cell lung cancer cells by a dietary flavonoid fisetin. Int J Cancer 130:1695\u20131705. https:\/\/doi.org\/10.1002\/ijc.26178","journal-title":"Int J Cancer"},{"key":"10128_CR79","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.3390\/antiox12061284","volume":"12","author":"A Khan","year":"2023","unstructured":"Khan A, Park JS, Kang MH et al (2023) Caffeic acid, a polyphenolic micronutrient rescues mice brains against a\u03b2-induced neurodegeneration and memory impairment. Antioxidants 12:1284. https:\/\/doi.org\/10.3390\/antiox12061284","journal-title":"Antioxidants"},{"key":"10128_CR80","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.bbi.2021.09.002","volume":"98","author":"N Kim","year":"2021","unstructured":"Kim N, Jeon SH, Ju IG et al (2021) Transplantation of gut microbiota derived from Alzheimer\u2019s disease mouse model impairs memory function and neurogenesis in C57BL\/6 mice. Brain Behav Immun 98:357\u2013365. https:\/\/doi.org\/10.1016\/j.bbi.2021.09.002","journal-title":"Brain Behav Immun"},{"key":"10128_CR81","doi-asserted-by":"publisher","first-page":"25","DOI":"10.7326\/0003-4819-137-1-200207020-00009","volume":"137","author":"D Kirpichnikov","year":"2002","unstructured":"Kirpichnikov D, McFarlane SI, Sowers JR (2002) Metformin: an update. Ann Intern Med 137:25\u201333. https:\/\/doi.org\/10.7326\/0003-4819-137-1-200207020-00009","journal-title":"Ann Intern Med"},{"key":"10128_CR82","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s00406-007-0731-5","volume":"257","author":"F Klempin","year":"2007","unstructured":"Klempin F, Kempermann G (2007) Adult hippocampal neurogenesis and aging. Eur Arch Psychiatry Clin Neurosci 257:271\u2013280. https:\/\/doi.org\/10.1007\/s00406-007-0731-5","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10128_CR83","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/bab.2104","volume":"69","author":"L Kma","year":"2022","unstructured":"Kma L, Baruah TJ (2022) The interplay of ROS and the PI3K\/Akt pathway in autophagy regulation. Biotechnol Appl Biochem 69:248\u2013264. https:\/\/doi.org\/10.1002\/bab.2104","journal-title":"Biotechnol Appl Biochem"},{"key":"10128_CR84","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.cmet.2007.06.003","volume":"6","author":"N Kubota","year":"2007","unstructured":"Kubota N, Yano W, Kubota T et al (2007) Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab 6:55\u201368. https:\/\/doi.org\/10.1016\/j.cmet.2007.06.003","journal-title":"Cell Metab"},{"key":"10128_CR85","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2020.104133","volume":"90","author":"R Kumar","year":"2020","unstructured":"Kumar R, Saraswat K, Rizvi SI (2020) 2 \u2013Deoxy\u2014d-glucose at chronic low dose acts as a caloric restriction mimetic through a mitohormetic induction of ROS in the brain of accelerated senescence model of rat. Arch Gerontol Geriatr 90:104133. https:\/\/doi.org\/10.1016\/j.archger.2020.104133","journal-title":"Arch Gerontol Geriatr"},{"key":"10128_CR86","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1089\/rej.1.1998.1.327","volume":"1","author":"MA Lane","year":"1998","unstructured":"Lane MA, Ingram DK, Roth GS (1998) 2-Deoxy-d-glucose feeding in rats mimics physiologic effects of calorie restriction. J Anti Aging Med 1:327\u2013337. https:\/\/doi.org\/10.1089\/rej.1.1998.1.327","journal-title":"J Anti Aging Med"},{"key":"10128_CR87","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/s1063-4584(03)00028-1","volume":"11","author":"R Largo","year":"2003","unstructured":"Largo R, Alvarez-Soria MA, D\u00edez-Ortego I et al (2003) Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes. Osteoarthr Cartil 11:290\u2013298. https:\/\/doi.org\/10.1016\/s1063-4584(03)00028-1","journal-title":"Osteoarthr Cartil"},{"key":"10128_CR88","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1385\/JMN:15:2:99","volume":"15","author":"J Lee","year":"2000","unstructured":"Lee J, Duan W, Long JM et al (2000) Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats. J Mol Neurosci 15:99\u2013108. https:\/\/doi.org\/10.1385\/JMN:15:2:99","journal-title":"J Mol Neurosci"},{"key":"10128_CR89","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.2337\/db06-0006","volume":"55","author":"YS Lee","year":"2006","unstructured":"Lee YS, Kim W, Kim K et al (2006) Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 55:2256\u20132264. https:\/\/doi.org\/10.2337\/db06-0006","journal-title":"Diabetes"},{"key":"10128_CR90","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3390\/cells13010103","volume":"13","author":"C Li\u00e9nard","year":"2024","unstructured":"Li\u00e9nard C, Pintart A, Bomont P (2024) Neuronal autophagy: regulations and implications in health and disease. Cells 13:103. https:\/\/doi.org\/10.3390\/cells13010103","journal-title":"Cells"},{"key":"10128_CR91","doi-asserted-by":"publisher","first-page":"4212","DOI":"10.3390\/molecules26144212","volume":"26","author":"K Likhitwitayawuid","year":"2021","unstructured":"Likhitwitayawuid K (2021) Oxyresveratrol: sources, productions, biological activities, pharmacokinetics, and delivery systems. Molecules 26:4212. https:\/\/doi.org\/10.3390\/molecules26144212","journal-title":"Molecules"},{"key":"10128_CR92","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/s12974-014-0177-4","volume":"11","author":"Y Liu","year":"2014","unstructured":"Liu Y, Tang G, Li Y et al (2014) Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion. J Neuroinflammation 11:177. https:\/\/doi.org\/10.1186\/s12974-014-0177-4","journal-title":"J Neuroinflammation"},{"key":"10128_CR93","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.molmet.2017.12.003","volume":"8","author":"S Liu","year":"2018","unstructured":"Liu S, Marcelin G, Blouet C et al (2018) A gut-brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus. Mol Metab 8:37\u201350. https:\/\/doi.org\/10.1016\/j.molmet.2017.12.003","journal-title":"Mol Metab"},{"key":"10128_CR94","doi-asserted-by":"publisher","first-page":"53","DOI":"10.4103\/1673-5374.315227","volume":"17","author":"C Liu","year":"2022","unstructured":"Liu C, Yang S-Y, Wang L, Zhou F (2022) The gut microbiome: implications for neurogenesis and neurological diseases. Neural Regen Res 17:53\u201358. https:\/\/doi.org\/10.4103\/1673-5374.315227","journal-title":"Neural Regen Res"},{"key":"10128_CR95","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1038\/nature11550","volume":"489","author":"CA Lozupone","year":"2012","unstructured":"Lozupone CA, Stombaugh JI, Gordon JI et al (2012) Diversity, stability and resilience of the human gut microbiota. Nature 489:220\u2013230. https:\/\/doi.org\/10.1038\/nature11550","journal-title":"Nature"},{"key":"10128_CR96","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1097\/JBR.0000000000000055","volume":"3","author":"M Lu","year":"2020","unstructured":"Lu M, Chen H, Nie F et al (2020) The potential role of metformin in the treatment of Parkinson\u2019s disease. J Bio-X Res 3:27. https:\/\/doi.org\/10.1097\/JBR.0000000000000055","journal-title":"J Bio-X Res"},{"key":"10128_CR97","doi-asserted-by":"publisher","first-page":"2707","DOI":"10.1007\/s12011-020-02398-z","volume":"199","author":"Y Ma","year":"2021","unstructured":"Ma Y, Shi Y, Wu Q, Ma W (2021) Epigallocatechin-3-gallate alleviates vanadium-induced reduction of antioxidant capacity via keap1-Nrf2-smaf pathway in the liver, kidney, and ovary of laying hens. Biol Trace Elem Res 199:2707\u20132716. https:\/\/doi.org\/10.1007\/s12011-020-02398-z","journal-title":"Biol Trace Elem Res"},{"key":"10128_CR98","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1111\/j.1365-2672.2007.03287.x","volume":"102","author":"S Macfarlane","year":"2007","unstructured":"Macfarlane S, Dillon JF (2007) Microbial biofilms in the human gastrointestinal tract. J Appl Microbiol 102:1187\u20131196. https:\/\/doi.org\/10.1111\/j.1365-2672.2007.03287.x","journal-title":"J Appl Microbiol"},{"key":"10128_CR99","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.cmet.2019.01.018","volume":"29","author":"F Madeo","year":"2019","unstructured":"Madeo F, Carmona-Gutierrez D, Hofer SJ, Kroemer G (2019a) Caloric restriction mimetics against age-associated disease: targets, mechanisms, and therapeutic potential. Cell Metab 29:592\u2013610. https:\/\/doi.org\/10.1016\/j.cmet.2019.01.018","journal-title":"Cell Metab"},{"key":"10128_CR100","doi-asserted-by":"publisher","first-page":"4970","DOI":"10.1038\/s41467-023-40734-8","volume":"14","author":"J Mandrioli","year":"2023","unstructured":"Mandrioli J, D\u2019Amico R, Zucchi E et al (2023) Randomized, double-blind, placebo-controlled trial of rapamycin in amyotrophic lateral sclerosis. Nat Commun 14:4970. https:\/\/doi.org\/10.1038\/s41467-023-40734-8","journal-title":"Nat Commun"},{"key":"10128_CR101","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1016\/j.molcel.2014.01.016","volume":"53","author":"G Mari\u00f1o","year":"2014","unstructured":"Mari\u00f1o G, Pietrocola F, Eisenberg T et al (2014) Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell 53:710\u2013725. https:\/\/doi.org\/10.1016\/j.molcel.2014.01.016","journal-title":"Mol Cell"},{"key":"10128_CR102","doi-asserted-by":"publisher","first-page":"18171","DOI":"10.1073\/pnas.0405831102","volume":"101","author":"N Maswood","year":"2004","unstructured":"Maswood N, Young J, Tilmont E et al (2004) Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson\u2019s disease. Proc Natl Acad Sci USA 101:18171\u201318176. https:\/\/doi.org\/10.1073\/pnas.0405831102","journal-title":"Proc Natl Acad Sci USA"},{"key":"10128_CR103","doi-asserted-by":"publisher","first-page":"1161814","DOI":"10.3389\/fragi.2023.1161814","volume":"4","author":"E Mayor","year":"2023","unstructured":"Mayor E (2023) Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography. Front Aging 4:1161814. https:\/\/doi.org\/10.3389\/fragi.2023.1161814","journal-title":"Front Aging"},{"key":"10128_CR104","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1038\/s41380-022-01456-3","volume":"27","author":"AJ McGuinness","year":"2022","unstructured":"McGuinness AJ, Davis JA, Dawson SL et al (2022) A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia. Mol Psychiatry 27:1920\u20131935. https:\/\/doi.org\/10.1038\/s41380-022-01456-3","journal-title":"Mol Psychiatry"},{"key":"10128_CR105","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s40263-024-01073-4","volume":"38","author":"E Menozzi","year":"2024","unstructured":"Menozzi E, Schapira AHV (2024) The gut microbiota in parkinson disease: interactions with drugs and potential for therapeutic applications. CNS Drugs 38:315\u2013331. https:\/\/doi.org\/10.1007\/s40263-024-01073-4","journal-title":"CNS Drugs"},{"key":"10128_CR106","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20070140","volume":"404","author":"S Michan","year":"2007","unstructured":"Michan S, Sinclair D (2007) Sirtuins in mammals: insights into their biological function. Biochem J 404:1\u201313. https:\/\/doi.org\/10.1042\/BJ20070140","journal-title":"Biochem J"},{"key":"10128_CR107","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111661","volume":"139","author":"R Mirzaei","year":"2021","unstructured":"Mirzaei R, Bouzari B, Hosseini-Fard SR et al (2021) Role of microbiota-derived short-chain fatty acids in nervous system disorders. Biomed Pharmacother 139:111661. https:\/\/doi.org\/10.1016\/j.biopha.2021.111661","journal-title":"Biomed Pharmacother"},{"key":"10128_CR108","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1016\/j.celrep.2016.04.074","volume":"15","author":"L M\u00f6hle","year":"2016","unstructured":"M\u00f6hle L, Mattei D, Heimesaat MM et al (2016) Ly6C(hi) monocytes provide a link between antibiotic-induced changes in gut microbiota and adult hippocampal neurogenesis. Cell Rep 15:1945\u20131956. https:\/\/doi.org\/10.1016\/j.celrep.2016.04.074","journal-title":"Cell Rep"},{"key":"10128_CR109","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1080\/19490976.2020.1712985","volume":"11","author":"S Moran-Ramos","year":"2020","unstructured":"Moran-Ramos S, Lopez-Contreras BE, Villarruel-Vazquez R et al (2020) Environmental and intrinsic factors shaping gut microbiota composition and diversity and its relation to metabolic health in children and early adolescents: a population-based study. Gut Microbes 11:900\u2013917. https:\/\/doi.org\/10.1080\/19490976.2020.1712985","journal-title":"Gut Microbes"},{"key":"10128_CR110","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2009.8","volume":"1","author":"E Morselli","year":"2010","unstructured":"Morselli E, Maiuri MC, Markaki M et al (2010) Caloric restriction and resveratrol promote longevity through the sirtuin-1-dependent induction of autophagy. Cell Death Dis 1:e10. https:\/\/doi.org\/10.1038\/cddis.2009.8","journal-title":"Cell Death Dis"},{"key":"10128_CR111","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1083\/jcb.201008167","volume":"192","author":"E Morselli","year":"2011","unstructured":"Morselli E, Mari\u00f1o G, Bennetzen MV et al (2011) Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol 192:615\u2013629. https:\/\/doi.org\/10.1083\/jcb.201008167","journal-title":"J Cell Biol"},{"key":"10128_CR112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-016-0779-0","volume":"14","author":"C Moussa","year":"2017","unstructured":"Moussa C, Hebron M, Huang X et al (2017) Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer\u2019s disease. J Neuroinflammation 14:1. https:\/\/doi.org\/10.1186\/s12974-016-0779-0","journal-title":"J Neuroinflammation"},{"key":"10128_CR113","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117534","volume":"10","author":"SL Navarro","year":"2015","unstructured":"Navarro SL, White E, Kantor ED et al (2015) Randomized trial of glucosamine and chondroitin supplementation on inflammation and oxidative stress biomarkers and plasma proteomics profiles in healthy humans. PLoS ONE 10:e0117534. https:\/\/doi.org\/10.1371\/journal.pone.0117534","journal-title":"PLoS ONE"},{"key":"10128_CR114","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s10522-024-10102-0","volume":"25","author":"B Papila","year":"2024","unstructured":"Papila B, Karimova A, Onaran I (2024) Altered lactate\/pyruvate ratio may be responsible for aging-associated intestinal barrier dysfunction in male rats. Biogerontology 25:679\u2013689. https:\/\/doi.org\/10.1007\/s10522-024-10102-0","journal-title":"Biogerontology"},{"key":"10128_CR115","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0299042","volume":"19","author":"D-J Park","year":"2024","unstructured":"Park D-J, Kang J-B, Koh P-O (2024) Epigallocatechin gallate improves neuronal damage in animal model of ischemic stroke and glutamate-exposed neurons via modulation of hippocalcin expression. PLoS ONE 19:e0299042. https:\/\/doi.org\/10.1371\/journal.pone.0299042","journal-title":"PLoS ONE"},{"key":"10128_CR116","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/s00508-020-01758-y","volume":"133","author":"T Pekar","year":"2021","unstructured":"Pekar T, Bruckner K, Pauschenwein-Frantsich S et al (2021) The positive effect of spermidine in older adults suffering from dementia: first results of a 3-month trial. Wien Klin Wochenschr 133:484\u2013491. https:\/\/doi.org\/10.1007\/s00508-020-01758-y","journal-title":"Wien Klin Wochenschr"},{"key":"10128_CR117","doi-asserted-by":"publisher","first-page":"1206572","DOI":"10.3389\/fnagi.2023.1206572","volume":"15","author":"Y Peng","year":"2023","unstructured":"Peng Y, Jin H, Xue Y-H et al (2023) Current and future therapeutic strategies for Alzheimer\u2019s disease: an overview of drug development bottlenecks. Front Aging Neurosci 15:1206572. https:\/\/doi.org\/10.3389\/fnagi.2023.1206572","journal-title":"Front Aging Neurosci"},{"key":"10128_CR118","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/s0095-5108(02)00051-9","volume":"29","author":"JM Perlman","year":"2002","unstructured":"Perlman JM (2002) Cognitive and behavioral deficits in premature graduates of intensive care. Clin Perinatol 29:779\u2013797. https:\/\/doi.org\/10.1016\/s0095-5108(02)00051-9","journal-title":"Clin Perinatol"},{"key":"10128_CR119","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3945\/ajcn.2009.28157","volume":"91","author":"OJ Phung","year":"2010","unstructured":"Phung OJ, Baker WL, Matthews LJ et al (2010) Effect of green tea catechins with or without caffeine on anthropometric measures: a systematic review and meta-analysis. Am J Clin Nutr 91:73\u201381. https:\/\/doi.org\/10.3945\/ajcn.2009.28157","journal-title":"Am J Clin Nutr"},{"key":"10128_CR120","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1007\/s11357-012-9465-z","volume":"35","author":"A Picca","year":"2013","unstructured":"Picca A, Fracasso F, Pesce V et al (2013) Age- and calorie restriction-related changes in rat brain mitochondrial DNA and TFAM binding. Age (dordr) 35:1607\u20131620. https:\/\/doi.org\/10.1007\/s11357-012-9465-z","journal-title":"Age (dordr)"},{"key":"10128_CR121","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1080\/15548627.2018.1454810","volume":"14","author":"F Pietrocola","year":"2018","unstructured":"Pietrocola F, Castoldi F, Maiuri MC, Kroemer G (2018) Aspirin\u2014another caloric-restriction mimetic. Autophagy 14:1162\u20131163. https:\/\/doi.org\/10.1080\/15548627.2018.1454810","journal-title":"Autophagy"},{"key":"10128_CR122","doi-asserted-by":"publisher","first-page":"19299","DOI":"10.1038\/s41598-020-76219-7","volume":"10","author":"M Portero-Tresserra","year":"2020","unstructured":"Portero-Tresserra M, Rojic-Becker D, Vega-Carbajal C et al (2020) Caloric restriction modulates the monoaminergic system and metabolic hormones in aged rats. Sci Rep 10:19299. https:\/\/doi.org\/10.1038\/s41598-020-76219-7","journal-title":"Sci Rep"},{"key":"10128_CR123","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.cmet.2012.04.003","volume":"15","author":"NL Price","year":"2012","unstructured":"Price NL, Gomes AP, Ling AJY et al (2012) SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab 15:675\u2013690. https:\/\/doi.org\/10.1016\/j.cmet.2012.04.003","journal-title":"Cell Metab"},{"key":"10128_CR124","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2022.111666","volume":"204","author":"M Prvulovic","year":"2022","unstructured":"Prvulovic M, Todorovic S, Milanovic D et al (2022) Calorie restriction changes the anxiety-like behaviour of ageing male Wistar rats in an onset- and duration-dependent manner. Mech Ageing Dev 204:111666. https:\/\/doi.org\/10.1016\/j.mad.2022.111666","journal-title":"Mech Ageing Dev"},{"key":"10128_CR125","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1196\/annals.1427.024","volume":"1147","author":"W Qin","year":"2008","unstructured":"Qin W, Zhao W, Ho L et al (2008) Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer\u2019s disease-type amyloid neuropathology and spatial memory deterioration. Ann NY Acad Sci 1147:335\u2013347. https:\/\/doi.org\/10.1196\/annals.1427.024","journal-title":"Ann NY Acad Sci"},{"key":"10128_CR126","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10522-023-10089-0","volume":"25","author":"SIS Rattan","year":"2024","unstructured":"Rattan SIS (2024) Seven knowledge gaps in modern biogerontology. Biogerontology 25:1\u20138. https:\/\/doi.org\/10.1007\/s10522-023-10089-0","journal-title":"Biogerontology"},{"key":"10128_CR127","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00218","author":"SD Rege","year":"2014","unstructured":"Rege SD, Geetha T, Griffin GD et al (2014a) Neuroprotective effects of resveratrol in Alzheimer disease pathology. Front Aging Neurosci. https:\/\/doi.org\/10.3389\/fnagi.2014.00218","journal-title":"Front Aging Neurosci"},{"key":"10128_CR128","doi-asserted-by":"publisher","first-page":"5890","DOI":"10.3390\/ijms20235890","volume":"20","author":"C-S Rha","year":"2019","unstructured":"Rha C-S, Seong H, Jung YS et al (2019) Stability and fermentability of green tea flavonols in in-vitro-simulated gastrointestinal digestion and human fecal fermentation. Int J Mol Sci 20:5890. https:\/\/doi.org\/10.3390\/ijms20235890","journal-title":"Int J Mol Sci"},{"key":"10128_CR129","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/nrgastro.2009.35","volume":"6","author":"SH Rhee","year":"2009","unstructured":"Rhee SH, Pothoulakis C, Mayer EA (2009) Principles and clinical implications of the brain-gut-enteric microbiota axis. Nat Rev Gastroenterol Hepatol 6:306\u2013314. https:\/\/doi.org\/10.1038\/nrgastro.2009.35","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10128_CR130","doi-asserted-by":"publisher","first-page":"fcaa165","DOI":"10.1093\/braincomms\/fcaa165","volume":"2","author":"MF Ribeiro","year":"2020","unstructured":"Ribeiro MF, Santos AA, Afonso MB et al (2020) Diet-dependent gut microbiota impacts on adult neurogenesis through mitochondrial stress modulation. Brain Commun 2:fcaa165. https:\/\/doi.org\/10.1093\/braincomms\/fcaa165","journal-title":"Brain Commun"},{"key":"10128_CR131","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/microorganisms7010014","volume":"7","author":"E Rinninella","year":"2019","unstructured":"Rinninella E, Raoul P, Cintoni M et al (2019) What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases. Microorganisms 7:14. https:\/\/doi.org\/10.3390\/microorganisms7010014","journal-title":"Microorganisms"},{"key":"10128_CR132","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41531-021-00156-z","volume":"7","author":"S Romano","year":"2021","unstructured":"Romano S, Savva GM, Bedarf JR et al (2021) Meta-analysis of the Parkinson\u2019s disease gut microbiome suggests alterations linked to intestinal inflammation. Npj Parkinsons Dis 7:1\u201313. https:\/\/doi.org\/10.1038\/s41531-021-00156-z","journal-title":"Npj Parkinsons Dis"},{"key":"10128_CR133","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.3390\/ijms22062973","volume":"22","author":"W Roth","year":"2021","unstructured":"Roth W, Zadeh K, Vekariya R et al (2021) Tryptophan metabolism and gut-brain homeostasis. Int J Mol Sci 22:2973. https:\/\/doi.org\/10.3390\/ijms22062973","journal-title":"Int J Mol Sci"},{"key":"10128_CR134","doi-asserted-by":"publisher","first-page":"5474","DOI":"10.3390\/molecules25225474","volume":"25","author":"S Saha","year":"2020","unstructured":"Saha S, Buttari B, Panieri E et al (2020) An overview of Nrf2 signaling pathway and its role in inflammation. Molecules 25:5474. https:\/\/doi.org\/10.3390\/molecules25225474","journal-title":"Molecules"},{"key":"10128_CR135","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/nyas.13431","volume":"1403","author":"C Sawda","year":"2017","unstructured":"Sawda C, Moussa C, Turner RS (2017) Resveratrol for Alzheimer\u2019s disease. Ann NY Acad Sci 1403:142\u2013149. https:\/\/doi.org\/10.1111\/nyas.13431","journal-title":"Ann NY Acad Sci"},{"key":"10128_CR136","doi-asserted-by":"publisher","first-page":"91","DOI":"10.31887\/DCNS.2000.2.2\/asschachter","volume":"2","author":"AS Schachter","year":"2000","unstructured":"Schachter AS, Davis KL (2000) Alzheimer\u2019s disease. Dialogues Clin Neurosci 2:91\u2013100","journal-title":"Dialogues Clin Neurosci"},{"key":"10128_CR137","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.cell.2016.01.013","volume":"164","author":"R Sender","year":"2016","unstructured":"Sender R, Fuchs S, Milo R (2016) Are We Really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell 164:337\u2013340. https:\/\/doi.org\/10.1016\/j.cell.2016.01.013","journal-title":"Cell"},{"key":"10128_CR138","doi-asserted-by":"publisher","first-page":"9917","DOI":"10.1523\/JNEUROSCI.0621-17.2017","volume":"37","author":"J Seo","year":"2017","unstructured":"Seo J, Kritskiy O, Watson LA et al (2017) Inhibition of p25\/Cdk5 attenuates tauopathy in mouse and iPSC models of frontotemporal dementia. J Neurosci 37:9917\u20139924. https:\/\/doi.org\/10.1523\/JNEUROSCI.0621-17.2017","journal-title":"J Neurosci"},{"key":"10128_CR139","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.34722","volume":"15","author":"H Shalabi","year":"2023","unstructured":"Shalabi H, Hassan AS, Al-Zahrani FA et al (2023) Intermittent fasting: benefits, side effects, quality of life, and knowledge of the saudi population. Cureus 15:e34722. https:\/\/doi.org\/10.7759\/cureus.34722","journal-title":"Cureus"},{"key":"10128_CR140","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s10522-023-10045-y","volume":"24","author":"A Sharma","year":"2023","unstructured":"Sharma A, Singh AK (2023) Molecular mechanism of caloric restriction mimetics-mediated neuroprotection of age-related neurodegenerative diseases: an emerging therapeutic approach. Biogerontology 24:679\u2013708. https:\/\/doi.org\/10.1007\/s10522-023-10045-y","journal-title":"Biogerontology"},{"key":"10128_CR141","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1016\/j.bbrc.2017.09.147","volume":"493","author":"T Shintani","year":"2017","unstructured":"Shintani T, Sakoguchi H, Yoshihara A et al (2017) d-Allulose, a stereoisomer of d-fructose, extends caenorhabditis elegans lifespan through a dietary restriction mechanism: a new candidate dietary restriction mimetic. Biochem Biophys Res Commun 493:1528\u20131533. https:\/\/doi.org\/10.1016\/j.bbrc.2017.09.147","journal-title":"Biochem Biophys Res Commun"},{"key":"10128_CR142","doi-asserted-by":"publisher","first-page":"3475","DOI":"10.1007\/s11357-023-00851-0","volume":"45","author":"T Shintani","year":"2023","unstructured":"Shintani T, Shintani H, Sato M, Ashida H (2023) Calorie restriction mimetic drugs could favorably influence gut microbiota leading to lifespan extension. GeroScience 45:3475\u20133490. https:\/\/doi.org\/10.1007\/s11357-023-00851-0","journal-title":"GeroScience"},{"key":"10128_CR143","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.626359","volume":"12","author":"L Silami\u0137ele","year":"2021","unstructured":"Silami\u0137ele L, Silami\u0137elis I, Ustinova M et al (2021) Metformin strongly affects gut microbiome composition in high-fat diet-induced type 2 diabetes mouse model of both sexes. Front Endocrinol 12:626359. https:\/\/doi.org\/10.3389\/fendo.2021.626359","journal-title":"Front Endocrinol"},{"key":"10128_CR144","doi-asserted-by":"publisher","first-page":"7116","DOI":"10.3390\/app11157116","volume":"11","author":"S Silvestro","year":"2021","unstructured":"Silvestro S, Bramanti P, Mazzon E (2021) Role of quercetin in depressive-like behaviors: findings from animal models. Appl Sci 11:7116. https:\/\/doi.org\/10.3390\/app11157116","journal-title":"Appl Sci"},{"key":"10128_CR145","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10522-020-09900-z","volume":"22","author":"S Singh","year":"2021","unstructured":"Singh S, Kumar R, Garg G et al (2021) Spermidine, a caloric restriction mimetic, provides neuroprotection against normal and D-galactose-induced oxidative stress and apoptosis through activation of autophagy in male rats during aging. Biogerontology 22:35\u201347. https:\/\/doi.org\/10.1007\/s10522-020-09900-z","journal-title":"Biogerontology"},{"key":"10128_CR146","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s42977-023-00170-7","volume":"74","author":"A Singh","year":"2023","unstructured":"Singh A, Srivastava P, Verma AK et al (2023) Curcumin displays a potent caloric restriction mimetic effect in an accelerated senescent model of rat. Biol Futur 74:221\u2013229. https:\/\/doi.org\/10.1007\/s42977-023-00170-7","journal-title":"Biol Futur"},{"key":"10128_CR147","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1007\/s11357-020-00278-x","volume":"43","author":"DL Smith","year":"2021","unstructured":"Smith DL, Orlandella RM, Allison DB, Norian LA (2021) Diabetes medications as potential calorie restriction mimetics\u2014a focus on the alpha-glucosidase inhibitor acarbose. GeroScience 43:1123\u20131133. https:\/\/doi.org\/10.1007\/s11357-020-00278-x","journal-title":"GeroScience"},{"key":"10128_CR148","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1002\/jsfa.11458","volume":"102","author":"X Song","year":"2022","unstructured":"Song X, Liu L, Peng S et al (2022) Resveratrol regulates intestinal barrier function in cyclophosphamide-induced immunosuppressed mice. J Sci Food Agric 102:1205\u20131215. https:\/\/doi.org\/10.1002\/jsfa.11458","journal-title":"J Sci Food Agric"},{"key":"10128_CR149","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-024-01510-2","author":"D Soni","year":"2024","unstructured":"Soni D, Upadhayay S, Dhureja M et al (2024) Crosstalk between gut\u2013brain axis: unveiling the mysteries of gut ROS in progression of Parkinson\u2019s disease. Inflammopharmacol. https:\/\/doi.org\/10.1007\/s10787-024-01510-2","journal-title":"Inflammopharmacol"},{"issue":"Suppl 1","key":"10128_CR150","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1159\/000508054","volume":"75","author":"P Steiner","year":"2019","unstructured":"Steiner P (2019) Brain fuel utilization in the developing brain. Ann Nutr Metab 75(Suppl 1):8\u201318. https:\/\/doi.org\/10.1159\/000508054","journal-title":"Ann Nutr Metab"},{"key":"10128_CR151","doi-asserted-by":"publisher","first-page":"3101","DOI":"10.1007\/s00125-011-2311-5","volume":"54","author":"X Stephenne","year":"2011","unstructured":"Stephenne X, Foretz M, Taleux N et al (2011) Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status. Diabetologia 54:3101\u20133110. https:\/\/doi.org\/10.1007\/s00125-011-2311-5","journal-title":"Diabetologia"},{"key":"10128_CR152","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.brainres.2018.03.015","volume":"1693","author":"P Strandwitz","year":"2018","unstructured":"Strandwitz P (2018) Neurotransmitter modulation by the gut microbiota. Brain Res 1693:128\u2013133. https:\/\/doi.org\/10.1016\/j.brainres.2018.03.015","journal-title":"Brain Res"},{"key":"10128_CR153","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1113\/jphysiol.2004.063388","volume":"558","author":"N Sudo","year":"2004","unstructured":"Sudo N, Chida Y, Aiba Y et al (2004) Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J Physiol 558:263\u2013275. https:\/\/doi.org\/10.1113\/jphysiol.2004.063388","journal-title":"J Physiol"},{"key":"10128_CR154","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100831RR","volume":"36","author":"M Takahara","year":"2022","unstructured":"Takahara M, Takaki A, Hiraoka S et al (2022) Metformin ameliorates chronic colitis in a mouse model by regulating interferon-\u03b3-producing lamina propria CD4+ T cells through AMPK activation. FASEB J 36:e22139. https:\/\/doi.org\/10.1096\/fj.202100831RR","journal-title":"FASEB J"},{"key":"10128_CR155","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.cmet.2011.10.002","volume":"14","author":"S Timmers","year":"2011","unstructured":"Timmers S, Konings E, Bilet L et al (2011) Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 14:612\u2013622. https:\/\/doi.org\/10.1016\/j.cmet.2011.10.002","journal-title":"Cell Metab"},{"key":"10128_CR156","doi-asserted-by":"publisher","first-page":"732","DOI":"10.3390\/nu13030732","volume":"13","author":"SM-S Tran","year":"2021","unstructured":"Tran SM-S, Mohajeri MH (2021) The Role of gut bacterial metabolites in brain development. Aging Dis Nutr 13:732. https:\/\/doi.org\/10.3390\/nu13030732","journal-title":"Aging Dis Nutr"},{"key":"10128_CR157","doi-asserted-by":"publisher","first-page":"9740","DOI":"10.3390\/ijms21249740","volume":"21","author":"LV Vasileva","year":"2020","unstructured":"Vasileva LV, Savova MS, Amirova KM et al (2020) Caffeic and chlorogenic acids synergistically activate browning program in human adipocytes: implications of AMPK-and PPAR-mediated pathways. Int J Mol Sci 21:9740. https:\/\/doi.org\/10.3390\/ijms21249740","journal-title":"Int J Mol Sci"},{"key":"10128_CR158","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1007\/s11357-020-00211-2","volume":"42","author":"ICM Verheggen","year":"2020","unstructured":"Verheggen ICM, de Jong JJA, van Boxtel MPJ et al (2020) Increase in blood-brain barrier leakage in healthy, older adults. Geroscience 42:1183\u20131193. https:\/\/doi.org\/10.1007\/s11357-020-00211-2","journal-title":"Geroscience"},{"key":"10128_CR159","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1016\/j.celrep.2018.10.070","volume":"25","author":"D Wahl","year":"2018","unstructured":"Wahl D, Solon-Biet SM, Wang Q-P et al (2018) Comparing the effects of low-protein and high-carbohydrate diets and caloric restriction on brain aging in mice. Cell Rep 25:2234-2243.e6. https:\/\/doi.org\/10.1016\/j.celrep.2018.10.070","journal-title":"Cell Rep"},{"key":"10128_CR160","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1002\/ccr3.232","volume":"3","author":"C Wakade","year":"2015","unstructured":"Wakade C, Chong R, Bradley E, Morgan JC (2015) Low-dose niacin supplementation modulates GPR109A, niacin index and ameliorates Parkinson\u2019s disease symptoms without side effects. Clin Case Rep 3:635\u2013637. https:\/\/doi.org\/10.1002\/ccr3.232","journal-title":"Clin Case Rep"},{"key":"10128_CR161","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.4103\/0366-6999.190667","volume":"129","author":"H-X Wang","year":"2016","unstructured":"Wang H-X, Wang Y-P (2016) Gut microbiota-brain axis. Chin Med J 129:2373\u20132380. https:\/\/doi.org\/10.4103\/0366-6999.190667","journal-title":"Chin Med J"},{"key":"10128_CR162","doi-asserted-by":"publisher","first-page":"2522","DOI":"10.1007\/s10620-016-4184-4","volume":"61","author":"N Wang","year":"2016","unstructured":"Wang N, Han Q, Wang G et al (2016) Resveratrol protects oxidative stress-induced intestinal epithelial barrier dysfunction by upregulating heme oxygenase-1 expression. Dig Dis Sci 61:2522\u20132534. https:\/\/doi.org\/10.1007\/s10620-016-4184-4","journal-title":"Dig Dis Sci"},{"key":"10128_CR163","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.18632\/aging.101966","volume":"11","author":"N Wang","year":"2019","unstructured":"Wang N, Luo Z, Jin M et al (2019) Exploration of age-related mitochondrial dysfunction and the anti-aging effects of resveratrol in zebrafish retina. Aging 11:3117\u20133137. https:\/\/doi.org\/10.18632\/aging.101966","journal-title":"Aging"},{"key":"10128_CR164","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2020.103493","volume":"105","author":"TJ Wenzel","year":"2020","unstructured":"Wenzel TJ, Gates EJ, Ranger AL, Klegeris A (2020) Short-chain fatty acids (SCFAs) alone or in combination regulate select immune functions of microglia-like cells. Mol Cell Neurosci 105:103493. https:\/\/doi.org\/10.1016\/j.mcn.2020.103493","journal-title":"Mol Cell Neurosci"},{"key":"10128_CR165","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","volume":"186","author":"DM Wilson","year":"2023","unstructured":"Wilson DM, Cookson MR, Van Den Bosch L et al (2023) Hallmarks of neurodegenerative diseases. Cell 186:693\u2013714. https:\/\/doi.org\/10.1016\/j.cell.2022.12.032","journal-title":"Cell"},{"key":"10128_CR166","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.cortex.2018.09.014","volume":"109","author":"M Wirth","year":"2018","unstructured":"Wirth M, Benson G, Schwarz C et al (2018) The effect of spermidine on memory performance in older adults at risk for dementia: a randomized controlled trial. Cortex 109:181\u2013188. https:\/\/doi.org\/10.1016\/j.cortex.2018.09.014","journal-title":"Cortex"},{"key":"10128_CR167","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1016\/j.neurobiolaging.2007.03.028","volume":"29","author":"P Wu","year":"2008","unstructured":"Wu P, Shen Q, Dong S et al (2008) Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice. Neurobiol Aging 29:1502\u20131511. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2007.03.028","journal-title":"Neurobiol Aging"},{"key":"10128_CR168","doi-asserted-by":"publisher","first-page":"66","DOI":"10.2174\/1389203720666190819142746","volume":"21","author":"L Yang","year":"2020","unstructured":"Yang L, Jiang Y, Shi L et al (2020a) AMPK: Potential therapeutic target for Alzheimer\u2019s disease. Curr Protein Pept Sci 21:66\u201377. https:\/\/doi.org\/10.2174\/1389203720666190819142746","journal-title":"Curr Protein Pept Sci"},{"key":"10128_CR169","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1111\/jnc.14928","volume":"154","author":"LL Yang","year":"2020","unstructured":"Yang LL, Millischer V, Rodin S et al (2020b) Enteric short-chain fatty acids promote proliferation of human neural progenitor cells. J Neurochem 154:635\u2013646. https:\/\/doi.org\/10.1111\/jnc.14928","journal-title":"J Neurochem"},{"key":"10128_CR170","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.932294","volume":"13","author":"J-Y Yang","year":"2022","unstructured":"Yang J-Y, Liu M-J, Lv L et al (2022) Metformin alleviates irradiation-induced intestinal injury by activation of FXR in intestinal epithelia. Front Microbiol 13:932294. https:\/\/doi.org\/10.3389\/fmicb.2022.932294","journal-title":"Front Microbiol"},{"key":"10128_CR171","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079697","volume":"8","author":"Q Zhang","year":"2013","unstructured":"Zhang Q, Xiao X, Li M et al (2013) Acarbose reduces blood glucose by activating miR-10a-5p and miR-664 in diabetic rats. PLoS ONE 8:e79697. https:\/\/doi.org\/10.1371\/journal.pone.0079697","journal-title":"PLoS ONE"},{"key":"10128_CR172","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3390\/ijms21020493","volume":"21","author":"X-W Zhang","year":"2020","unstructured":"Zhang X-W, Chen J-Y, Ouyang D, Lu J-H (2020) Quercetin in animal models of Alzheimer\u2019s disease: a systematic review of preclinical studies. Int J Mol Sci 21:493. https:\/\/doi.org\/10.3390\/ijms21020493","journal-title":"Int J Mol Sci"},{"key":"10128_CR173","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.785644","author":"H Zhang","year":"2022","unstructured":"Zhang H, Chen Y, Wang Z et al (2022) Implications of gut microbiota in neurodegenerative diseases. Front Immunol. https:\/\/doi.org\/10.3389\/fimmu.2022.785644","journal-title":"Front Immunol"},{"key":"10128_CR174","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21431","volume":"9","author":"J Zhao","year":"2023","unstructured":"Zhao J, Zhao F, Yuan J et al (2023) Gut microbiota metabolites, redox status, and the related regulatory effects of probiotics. Heliyon 9:e21431. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e21431","journal-title":"Heliyon"},{"key":"10128_CR175","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.937555","volume":"13","author":"M Zhu","year":"2022","unstructured":"Zhu M, Liu X, Ye Y et al (2022) Gut microbiota: a novel therapeutic target for Parkinson\u2019s disease. Front Immunol 13:937555. https:\/\/doi.org\/10.3389\/fimmu.2022.937555","journal-title":"Front Immunol"},{"key":"10128_CR176","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s40168-023-01567-1","volume":"11","author":"X Zhu","year":"2023","unstructured":"Zhu X, Shen J, Feng S et al (2023) Akkermansia muciniphila, which is enriched in the gut microbiota by metformin, improves cognitive function in aged mice by reducing the proinflammatory cytokine interleukin-6. Microbiome 11:120. https:\/\/doi.org\/10.1186\/s40168-023-01567-1","journal-title":"Microbiome"}],"container-title":["Biogerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-024-10128-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10522-024-10128-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-024-10128-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T19:04:59Z","timestamp":1729191899000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10522-024-10128-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,23]]},"references-count":176,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10128"],"URL":"https:\/\/doi.org\/10.1007\/s10522-024-10128-4","relation":{},"ISSN":["1389-5729","1573-6768"],"issn-type":[{"value":"1389-5729","type":"print"},{"value":"1573-6768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,23]]},"assertion":[{"value":"13 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors report that there are no competing interests to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}