{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:33:07Z","timestamp":1790281987118,"version":"4.1.0"},"reference-count":192,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biogerontology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10522-025-10343-7","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T02:59:36Z","timestamp":1761879576000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The aging male: impact of aging on male reproduction"],"prefix":"10.1007","volume":"26","author":[{"given":"R. E.","family":"Akhigbe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Oyedokun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. E.","family":"Adeogun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. O.","family":"Ogunleye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Adegbola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. M.","family":"Akhigbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"10343_CR1","doi-asserted-by":"publisher","first-page":"1469340","DOI":"10.3389\/ftox.2024.1469340","volume":"6","author":"CA Adegbola","year":"2024","unstructured":"Adegbola CA, Akhigbe TM, Adeogun AE, Tvrd\u00e1 E, Pizent A, Akhigbe RE (2024) A systematic review and meta-analysis on the impact of triclosan exposure on human semen quality. Front Toxicol 6:1469340","journal-title":"Front Toxicol"},{"issue":"2","key":"10343_CR2","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1007\/s00210-024-03452-6","volume":"398","author":"AE Adeogun","year":"2025","unstructured":"Adeogun AE, Ogunleye OD, Akhigbe TM, Oyedokun PA, Adegbola CA, Saka WA, Afolabi OA, Akhigbe RE (2025) Impact of arsenic on male and female reproductive function: a review of the pathophysiology and potential therapeutic strategies. Naunyn-Schmiedebergs Arch Pharmacol 398(2):1283\u20131297","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"issue":"1","key":"10343_CR3","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1080\/13685538.2022.2104833","volume":"25","author":"DH Adeyemi","year":"2022","unstructured":"Adeyemi DH, Odetayo AF, Hamed MA, Akhigbe RE (2022) Impact of COVID 19 on erectile function. Aging Male 25(1):202\u2013216","journal-title":"Aging Male"},{"key":"10343_CR4","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1007\/s12013-024-01361-2","volume":"82","author":"D Adeyemi","year":"2024","unstructured":"Adeyemi D, Arokoyo D, Hamed M, Dare A, Oyedokun P, Akhigbe R (2024) Cardiometabolic disorder and erectile dysfunction. Cell Biochem Biophys 82:1751\u20131762","journal-title":"Cell Biochem Biophys"},{"key":"10343_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-811060-7.00005-X","volume-title":"The epigenetic regulation of telomere maintenance in aging","author":"H Adwan-Shekhidem","year":"2018","unstructured":"Adwan-Shekhidem H, Atzmon G (2018) The epigenetic regulation of telomere maintenance in aging. Academic Press, Epigenetics of aging and longevity"},{"issue":"6","key":"10343_CR6","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1080\/14737159.2019.1614916","volume":"19","author":"A Agarwal","year":"2019","unstructured":"Agarwal A, Panner Selvam MK, Baskaran S, Cho CL (2019) Sperm DNA damage and its impact on male reproductive health: a critical review for clinicians, reproductive professionals and researchers. Expert Rev Mol Diagn 19(6):443\u2013457","journal-title":"Expert Rev Mol Diagn"},{"key":"10343_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-815972-9.00002-0","volume-title":"Oxidative stress in pathologies of male reproductive disorders","author":"A Agarwal","year":"2020","unstructured":"Agarwal A, Leisegang K, Sengupta P (2020) Oxidative stress in pathologies of male reproductive disorders. Academic Press, Pathology"},{"issue":"1","key":"10343_CR8","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/molehr\/gap059","volume":"16","author":"RJ Aitken","year":"2010","unstructured":"Aitken RJ, De Iuliis GN (2010) On the possible origins of DNA damage in human spermatozoa. Mol Hum Reprod 16(1):3\u201313","journal-title":"Mol Hum Reprod"},{"issue":"1","key":"10343_CR9","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1080\/13510002.2020.1752003","volume":"25","author":"AF Ajayi","year":"2020","unstructured":"Ajayi AF, Akhigbe RE (2020) Codeine-induced sperm DNA damage is mediated predominantly by oxidative stress rather than apoptosis. Redox Rep 25(1):33\u201340","journal-title":"Redox Rep"},{"issue":"3","key":"10343_CR10","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1002\/biof.1831","volume":"48","author":"B Akbari","year":"2022","unstructured":"Akbari B, Baghaei-Yazdi N, Bahmaie M, Mahdavi Abhari F (2022) The role of plant-derived natural antioxidants in reduction of oxidative stress. BioFactors 48(3):611\u2013633","journal-title":"BioFactors"},{"key":"10343_CR11","doi-asserted-by":"publisher","first-page":"1657872","DOI":"10.3389\/frph.2025.1657872","volume":"7","author":"RE Akhigbe","year":"2025","unstructured":"Akhigbe RE (2025) Oxidative stress and male fertility. Front Reprod Health 7:1657872","journal-title":"Front Reprod Health"},{"key":"10343_CR12","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.reprotox.2021.06.007","volume":"103","author":"RE Akhigbe","year":"2021","unstructured":"Akhigbe RE, Hamed MA, Aremu AO (2021) HAART exacerbates testicular damage and impaired spermatogenesis in anti-Koch-treated rats via dysregulation of lactate transport and glutathione content. Reprod Toxicol 103:96\u2013107","journal-title":"Reprod Toxicol"},{"issue":"9","key":"10343_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0274411","volume":"17","author":"RE Akhigbe","year":"2022","unstructured":"Akhigbe RE, Afolabi OA, Ajayi AF (2022) L-arginine reverses maternal and pre-pubertal codeine exposure-induced sexual dysfunction via upregulation of androgen receptor gene and NO\/cGMP signaling. PLoS ONE 17(9):e0274411","journal-title":"PLoS ONE"},{"key":"10343_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1180085","volume":"14","author":"RE Akhigbe","year":"2023","unstructured":"Akhigbe RE, Afolabi OA, Ajayi AF (2023a) L-arginine abrogates maternal and pre-pubertal codeine exposure-induced impaired spermatogenesis and sperm quality by modulating the levels of mRNA encoding spermatogenic genes. Front Endocrinol 14:1180085","journal-title":"Front Endocrinol"},{"issue":"1","key":"10343_CR15","doi-asserted-by":"publisher","first-page":"2205517","DOI":"10.1080\/13685538.2023.2205517","volume":"26","author":"RE Akhigbe","year":"2023","unstructured":"Akhigbe RE, Hamed MA, Odetayo AF, Akhigbe TM, Oyedokun PA (2023b) Zinc improves sexual and erectile function in HAART-treated rats via the upregulation of erectogenic enzymes and maintenance of redox balance. Aging Male 26(1):2205517","journal-title":"Aging Male"},{"key":"10343_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2024.127489","volume":"85","author":"RE Akhigbe","year":"2024","unstructured":"Akhigbe RE, Adelowo OE, Ajani EO, Oyesetan RI, Oladapo DD, Akhigbe TM (2024a) Testicular toxicity in cisplatin-treated Wistar rats is mitigated by Daflon and associated with modulation of Nrf2\/HO-1 and TLR4\/NF-kB signaling. J Trace Elem Med Biol 85:127489","journal-title":"J Trace Elem Med Biol"},{"key":"10343_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116645","volume":"281","author":"RE Akhigbe","year":"2024","unstructured":"Akhigbe RE, Akhigbe TM, Adegbola CA, Oyedokun PA, Adesoye OB, Adeogun AE (2024b) Toxic impacts of arsenic bioaccumulation on urinary arsenic metabolites and semen quality: a systematic and meta-analysis. Ecotoxicol Environ Saf 281:116645","journal-title":"Ecotoxicol Environ Saf"},{"key":"10343_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1497930","volume":"15","author":"TM Akhigbe","year":"2025","unstructured":"Akhigbe TM, Fidelis FB, Adekunle AO, Ashonibare VJ, Akorede BA, Shuaibu MS, Hassan SA, Adegbola CA, Ashonibare PJ, Oladapo OM, Adeogun AE, Bamidele SG, Oyedokun PA, Mukolokota M, Kukoyi OS, Oladipo AA, Adelowo OE, Akangbe MD, Hughes JR, Ricken AM, Culty M, Avellar MCW, Akhigbe RE (2025) Does coenzyme Q10 improve semen quality and circulating testosterone level? A systematic review and meta-analysis of randomized controlled trials. Front Pharmacol 15:1497930. https:\/\/doi.org\/10.3389\/fphar.2024.1497930","journal-title":"Front Pharmacol"},{"issue":"1","key":"10343_CR19","doi-asserted-by":"publisher","first-page":"2336627","DOI":"10.1080\/13685538.2024.2336627","volume":"27","author":"BA Akorede","year":"2024","unstructured":"Akorede BA, Hassan SA, Akhigbe RE (2024) Penile erection and cardiovascular function: effects and pathophysiology. Aging Male 27(1):2336627","journal-title":"Aging Male"},{"issue":"12","key":"10343_CR20","doi-asserted-by":"publisher","first-page":"5671","DOI":"10.1007\/s12011-023-03638-8","volume":"201","author":"AT Alahmar","year":"2023","unstructured":"Alahmar AT (2023) The effect of selenium therapy on semen parameters, antioxidant capacity, and sperm DNA fragmentation in men with idiopathic oligoasthenoteratospermia. Biol Trace Elem Res 201(12):5671\u20135676","journal-title":"Biol Trace Elem Res"},{"issue":"2","key":"10343_CR21","doi-asserted-by":"publisher","first-page":"346","DOI":"10.5534\/wjmh.190145","volume":"39","author":"AT Alahmar","year":"2021","unstructured":"Alahmar AT, Calogero AE, Sengupta P, Dutta S (2021) Coenzyme Q10 improves sperm parameters, oxidative stress markers and sperm DNA fragmentation in infertile patients with idiopathic oligoasthenozoospermia. World J Mens Health 39(2):346","journal-title":"World J Mens Health"},{"key":"10343_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111831","volume":"141","author":"T Albrahim","year":"2021","unstructured":"Albrahim T, Alonazi MA (2021) Lycopene corrects metabolic syndrome and liver injury induced by high fat diet in obese rats through antioxidant, anti-inflammatory, antifibrotic pathways. Biomed Pharmacother 141:111831","journal-title":"Biomed Pharmacother"},{"key":"10343_CR23","doi-asserted-by":"publisher","first-page":"7941563","DOI":"10.1155\/2017\/7941563","volume":"2017","author":"AJPO Almeida","year":"2017","unstructured":"Almeida AJPO, Ribeiro TP, de Medeiros IA (2017) Aging: molecular pathways and implications on the cardiovascular system. Oxid Med Cell Longev 2017:7941563","journal-title":"Oxid Med Cell Longev"},{"issue":"30","key":"10343_CR24","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.2174\/1381612823666170503150313","volume":"23","author":"S Almeida","year":"2017","unstructured":"Almeida S, Rato L, Sousa M, Alves MG, Oliveira PF (2017b) Fertility and sperm quality in the aging male. Curr Pharm des 23(30):4429\u20134437","journal-title":"Curr Pharm des"},{"issue":"3","key":"10343_CR25","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s10522-021-09921-2","volume":"22","author":"I Almeida","year":"2021","unstructured":"Almeida I, Magalh\u00e3es S, Nunes A (2021) Lipids: biomarkers of healthy aging. Biogerontology 22(3):273\u2013295","journal-title":"Biogerontology"},{"issue":"3","key":"10343_CR26","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1093\/humrep\/14.3.731","volume":"14","author":"P Andolz","year":"1999","unstructured":"Andolz P, Bielsa MA, Vila J (1999) Evolution of semen quality in North-eastern Spain: a study in 22 759 infertile men over a 36-year period. Hum Reprod 14(3):731\u2013735","journal-title":"Hum Reprod"},{"issue":"2","key":"10343_CR27","doi-asserted-by":"publisher","first-page":"169","DOI":"10.4067\/S0716-97602011000200009","volume":"44","author":"C Angulo","year":"2011","unstructured":"Angulo C, Maldonado R, Pulgar E, Mancilla H, C\u00f3rdova A, Villarroel F, Castro MA, Concha II (2011) Vitamin c and oxidative stress in the seminiferous epithelium. Biol Res 44(2):169\u2013180","journal-title":"Biol Res"},{"issue":"9","key":"10343_CR28","doi-asserted-by":"publisher","first-page":"4028","DOI":"10.1021\/acsabm.2c00411","volume":"5","author":"MI Anik","year":"2022","unstructured":"Anik MI, Mahmud N, Masud AA, Khan MI, Islam MN, Uddin S, Hossain MK (2022) Role of reactive oxygen species in aging and age-related diseases: a review. ACS Appl Bio Mater 5(9):4028\u20134054","journal-title":"ACS Appl Bio Mater"},{"issue":"5","key":"10343_CR29","first-page":"246","volume":"41","author":"MO Appiah","year":"2020","unstructured":"Appiah MO, Asante-Badu B, Zhao J, Liu H, Wang J, Lu W (2020) Possible protective mechanisms of coenzyme Q10 action on spermatozoa during cryopreservation or cooled-stored condition. CryoLetters 41(5):246\u2013256","journal-title":"CryoLetters"},{"issue":"6","key":"10343_CR30","first-page":"493","volume":"19","author":"A Asadi","year":"2021","unstructured":"Asadi A, Ghahremani R, Abdolmaleki A, Rajaei F (2021) Role of sperm apoptosis and oxidative stress in male infertility: a narrative review. Int J Reprod Biomed 19(6):493","journal-title":"Int J Reprod Biomed"},{"key":"10343_CR31","doi-asserted-by":"crossref","unstructured":"Ashonibare, V.J. and Akhigbe, R.E., 2025. Psychoneuroimmunology: A Hallmark in Developmental Programming and Epigenetics. PsychoNeuroImmunology: Volume 1: Integration of Psychology, Neurology, and Immunology. Cham: Springer Nature Switzerland.","DOI":"10.1007\/978-3-031-73061-0_18"},{"issue":"12","key":"10343_CR32","doi-asserted-by":"publisher","first-page":"6806","DOI":"10.1002\/fsn3.2632","volume":"9","author":"A Babaei","year":"2021","unstructured":"Babaei A, Asadpour R, Mansouri K, Sabrivand A, Kazemi-Darabadi S (2021) Lycopene protects sperm from oxidative stress in the experimental varicocele model. Food Sci Nutr 9(12):6806\u20136817","journal-title":"Food Sci Nutr"},{"issue":"2","key":"10343_CR33","first-page":"99","volume":"17","author":"TG Bahar","year":"2023","unstructured":"Bahar TG, Masoumi SZ, Pilehvari S, Kazemi F, Moradkhani S, Shokoufeh M (2023) Effect of CoQ10 supplement on spermogram parameters and sexual function of infertile men referred to the infertility center of Fatemieh Hospital, Hamadan, Iran, 2019: a randomized controlled trial study. Int J Fertil Steril 17(2):99","journal-title":"Int J Fertil Steril"},{"issue":"3","key":"10343_CR34","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.fertnstert.2005.03.064","volume":"84","author":"G Balercia","year":"2005","unstructured":"Balercia G, Regoli F, Armeni T, Koverech A, Mantero F, Boscaro M (2005) Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia. Fertil Steril 84(3):662\u2013671","journal-title":"Fertil Steril"},{"key":"10343_CR35","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.exger.2015.02.014","volume":"68","author":"MC Beattie","year":"2015","unstructured":"Beattie MC, Adekola L, Papadopoulos V, Chen H, Zirkin BR (2015) Leydig cell aging and hypogonadism. Exp Gerontol 68:87\u201391","journal-title":"Exp Gerontol"},{"issue":"10","key":"10343_CR36","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/humrep\/deu189","volume":"29","author":"R Begueria","year":"2014","unstructured":"Begueria R, Garcia D, Obradors A, Poisot F, Vassena R, Vernaeve V (2014) Paternal age and assisted reproductive outcomes in ICSI donor oocytes: is there an effect of older fathers. Hum Reprod 29(10):2114\u20132122","journal-title":"Hum Reprod"},{"issue":"1","key":"10343_CR37","doi-asserted-by":"publisher","first-page":"2225675","DOI":"10.1080\/13510002.2023.2225675","volume":"28","author":"EE Besong","year":"2023","unstructured":"Besong EE, Akhigbe TM, Ashonibare PJ, Oladipo AA, Obimma JN, Hamed MA, Adeyemi DH, Akhigbe RE (2023a) Zinc improves sexual performance and erectile function by preventing penile oxidative injury and upregulating circulating testosterone in lead-exposed rats. Redox Rep 28(1):2225675","journal-title":"Redox Rep"},{"issue":"1","key":"10343_CR38","doi-asserted-by":"publisher","DOI":"10.1080\/13685538.2023.2224428","volume":"26","author":"EE Besong","year":"2023","unstructured":"Besong EE, Ashonibare PJ, Obembe OO, Folawiyo MA, Adeyemi DH, Hamed MA, Akhigbe TM, Akhigbe RE (2023b) Zinc protects against lead-induced testicular damage via modulation of steroidogenic and xanthine oxidase\/uric acid\/caspase 3-mediated apoptotic signaling in male Wistar rats. Aging Male 26(1):2224428","journal-title":"Aging Male"},{"issue":"2","key":"10343_CR39","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s00210-023-02696-y","volume":"397","author":"EE Besong","year":"2024","unstructured":"Besong EE, Ashonibare PJ, Akhigbe TM, Obimma JN, Akhigbe RE (2024) Sodium acetate abates lead-induced sexual dysfunction by upregulating testosterone-dependent eNOS\/NO\/cGMP signaling and activating Nrf2\/HO-1 in male Wistar rat. Naunyn-Schmiedebergs Arch Pharmacol 397(2):1233\u20131243","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"issue":"4","key":"10343_CR40","first-page":"265","volume":"21","author":"Z Beygi","year":"2021","unstructured":"Beygi Z, Forouhari S, Mahmoudi E, Hayat SM, Nourimand F (2021) Role of oxidative stress and antioxidant supplementation in male fertility. Curr Mol Med 21(4):265\u2013282","journal-title":"Curr Mol Med"},{"issue":"3","key":"10343_CR41","doi-asserted-by":"publisher","first-page":"420","DOI":"10.2741\/s495","volume":"9","author":"S Bisht","year":"2017","unstructured":"Bisht S, Dada RJFB (2017) Oxidative stress: Major executioner in disease pathology, role in sperm DNA damage and preventive strategies. Front Biosci (Schol Ed) 9(3):420\u2013447","journal-title":"Front Biosci (Schol Ed)"},{"issue":"6265","key":"10343_CR42","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1126\/science.aab3389","volume":"350","author":"EH Blackburn","year":"2015","unstructured":"Blackburn EH, Epel ES, Lin J (2015) Human telomere biology: a contributory and interactive factor in aging, disease risks, and protection. Science 350(6265):1193\u20131198","journal-title":"Science"},{"issue":"3","key":"10343_CR43","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1089\/bio.2020.0062","volume":"19","author":"Y Bozkurt","year":"2021","unstructured":"Bozkurt Y, Yava\u015f \u0130, Bucak MN, K\u0131ran TR, G\u00fcl A (2021) Cryoprotective effect of vitamin E supplementation of different extenders on quality and fertilizing ability of frozen-thawed brown trout sperm. Biopreserv Biobank 19(3):171\u2013177","journal-title":"Biopreserv Biobank"},{"key":"10343_CR44","doi-asserted-by":"publisher","first-page":"01","DOI":"10.31080\/ASNH.2020.04.0659","volume":"4","author":"AJAS Bratovcic","year":"2020","unstructured":"Bratovcic AJAS (2020) Antioxidant enzymes and their role in preventing cell damage. Acta Sci Nutritional Health 4:01\u201307","journal-title":"Acta Sci Nutritional Health"},{"issue":"1","key":"10343_CR45","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/S0022-5347(01)65369-2","volume":"157","author":"AL Burnett","year":"1997","unstructured":"Burnett AL (1997) Nitric oxide in the penis: physiology and pathology. J Urol 157(1):320\u2013324","journal-title":"J Urol"},{"issue":"1","key":"10343_CR46","doi-asserted-by":"publisher","DOI":"10.1186\/s43043-022-00094-7","volume":"27","author":"S Chakraborty","year":"2022","unstructured":"Chakraborty S, Saha S (2022) Understanding sperm motility mechanisms and the implication of sperm surface molecules in promoting motility. Middle East Fertil Soc J 27(1):4","journal-title":"Middle East Fertil Soc J"},{"key":"10343_CR47","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1210\/endo.143.5.8802","volume":"143","author":"H Chen","year":"2002","unstructured":"Chen H, Hardy MP, Zirkin BR (2002) Age-related decreases in Leydig cell testosterone production are not restored by exposure to LH in vitro. Endocrinology 143:1637\u20131642","journal-title":"Endocrinology"},{"issue":"1","key":"10343_CR48","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3390\/antiox10010092","volume":"10","author":"R Chianese","year":"2021","unstructured":"Chianese R, Pierantoni R (2021) Mitochondrial reactive oxygen species (ROS) production alters sperm quality. Antioxidants 10(1):92","journal-title":"Antioxidants"},{"issue":"1","key":"10343_CR49","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1743-6109.2010.01991.x","volume":"8","author":"G Corona","year":"2011","unstructured":"Corona G, Monami M, Rastrelli G, Aversa A, Tishova Y, Saad F, Lenzi A, Forti G, Mannucci E, Maggi M (2011) Testosterone and metabolic syndrome: a meta-analysis study. J Sex Med 8(1):272\u2013283","journal-title":"J Sex Med"},{"key":"10343_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2046-2395-3-1","volume":"3","author":"C Correia-Melo","year":"2014","unstructured":"Correia-Melo C, Hewitt G, Passos JF (2014) Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence? Longev Healthspan 3:1\u20139","journal-title":"Longev Healthspan"},{"issue":"6","key":"10343_CR51","doi-asserted-by":"publisher","first-page":"827","DOI":"10.3390\/biology12060827","volume":"12","author":"J Costa","year":"2023","unstructured":"Costa J, Braga PC, Rebelo I, Oliveira PF, Alves MG (2023) Mitochondria quality control and male fertility. Biol 12(6):827","journal-title":"Biol"},{"issue":"suppl_1","key":"10343_CR52","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/humrep\/10.suppl_1.15","volume":"10","author":"E De Lamirande","year":"1995","unstructured":"De Lamirande E, Gagnon C (1995) Impact of reactive oxygen species on spermatozoa: a balancing act between beneficial and detrimental effects. Hum Reprod 10(suppl_1):15\u201321","journal-title":"Hum Reprod"},{"issue":"9","key":"10343_CR53","doi-asserted-by":"publisher","first-page":"e2532405","DOI":"10.1001\/jamanetworkopen.2025.32405","volume":"8","author":"WR de Ligny","year":"2025","unstructured":"de Ligny WR, de Bruin JP, Smits RM, Goovaerts IG, Peeters K, Nap AW, Boxmeer JC, Donker RB, Schoonenberg M, Koks CA, van Rumste MM (2025) Antioxidant treatment and the chance to conceive in men seeking fertility care: the SUMMER randomized clinical trial. JAMA Netw Open 8(9):e2532405\u2013e2532405","journal-title":"JAMA Netw Open"},{"issue":"1","key":"10343_CR54","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1365-2265.2006.02560.x","volume":"65","author":"CA Derby","year":"2006","unstructured":"Derby CA, Zilber S, Brambilla D, Morales KH, McKinlay JB (2006) Body mass index, waist circumference and waist to hip ratio and change in sex steroid hormones: the Massachusetts male ageing study. Clin Endocrinol 65(1):125\u2013131","journal-title":"Clin Endocrinol"},{"issue":"6","key":"10343_CR55","doi-asserted-by":"publisher","DOI":"10.1111\/and.13023","volume":"50","author":"A Domos\u0142awska","year":"2018","unstructured":"Domos\u0142awska A, Zdunczyk S, Franczyk M, Kankofer M, Janowski T (2018) Selenium and vitamin E supplementation enhances the antioxidant status of spermatozoa and improves semen quality in male dogs with lowered fertility. Andrologia 50(6):e13023","journal-title":"Andrologia"},{"key":"10343_CR56","doi-asserted-by":"publisher","first-page":"1012119","DOI":"10.3389\/fendo.2022.1012119","volume":"13","author":"S Dong","year":"2022","unstructured":"Dong S, Chen C, Zhang J, Gao Y, Zeng X, Zhang X (2022) Testicular aging, male fertility and beyond. Front Endocrinol 13:1012119","journal-title":"Front Endocrinol"},{"issue":"3","key":"10343_CR57","doi-asserted-by":"publisher","first-page":"420","DOI":"10.4103\/1008-682X.126384","volume":"16","author":"D Durairajanayagam","year":"2014","unstructured":"Durairajanayagam D, Agarwal A, Ong C, Prashast P (2014) Lycopene and male infertility. Asian J Androl 16(3):420\u2013425","journal-title":"Asian J Androl"},{"issue":"18","key":"10343_CR58","doi-asserted-by":"publisher","first-page":"10043","DOI":"10.3390\/ijms221810043","volume":"22","author":"S Dutta","year":"2021","unstructured":"Dutta S, Sengupta P, Slama P, Roychoudhury S (2021) Oxidative stress, testicular inflammatory pathways, and male reproduction. Int J Mol Sci 22(18):10043","journal-title":"Int J Mol Sci"},{"key":"10343_CR59","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.aquaculture.2016.05.038","volume":"472","author":"B Dzyuba","year":"2017","unstructured":"Dzyuba B, Bondarenko O, Fedorov P, Gazo I, Prokopchuk G, Cosson J (2017) Energetics of fish spermatozoa: the proven and the possible. Aquaculture 472:60\u201372","journal-title":"Aquaculture"},{"issue":"3","key":"10343_CR60","first-page":"87","volume":"3","author":"M Eid Hammadeh","year":"2009","unstructured":"Eid Hammadeh M, Filippos A A, Faiz Hamad M (2009) Reactive oxygen species and antioxidant in seminal plasma and their impact on male fertility. Int J Fertil Steril 3(3):87\u2013110","journal-title":"Int J Fertil Steril"},{"issue":"4","key":"10343_CR61","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1007\/s11259-022-09991-8","volume":"46","author":"HR El-Sherbiny","year":"2022","unstructured":"El-Sherbiny HR, Abdelnaby EA, El-Shahat KH, Salem NY, Ramadan ES, Yehia SG, Fathi M (2022) Coenzyme Q10 supplementation enhances testicular volume and hemodynamics, reproductive hormones, sperm quality, and seminal antioxidant capacity in goat bucks under summer hot humid conditions. Vet Res Commun 46(4):1245\u20131257","journal-title":"Vet Res Commun"},{"issue":"2","key":"10343_CR62","doi-asserted-by":"publisher","first-page":"175","DOI":"10.4103\/fsr.fsr_49_20","volume":"7","author":"MA Emokpae","year":"2020","unstructured":"Emokpae MA, Ikuejamoye OG (2020) Seminal plasma cadmium\/zinc ratio among nonoccupationally exposed men investigated for infertility. Fert Sci Res 7(2):175\u2013182","journal-title":"Fert Sci Res"},{"issue":"1","key":"10343_CR63","first-page":"114","volume":"28","author":"GA Engwa","year":"2022","unstructured":"Engwa GA, Nweke FN, Nkeh-Chungag BN (2022) Free radicals, oxidative stress-related diseases and antioxidant supplementation. Altern Ther Health Med 28(1):114\u2013128","journal-title":"Altern Ther Health Med"},{"issue":"2","key":"10343_CR64","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1093\/humrep\/deg107","volume":"18","author":"B Eskenazi","year":"2003","unstructured":"Eskenazi B, Wyrobek AJ, Sloter E, Kidd SA, Moore L, Young S, Moore D (2003) The association of age and semen quality in healthy men. Hum Reprod 18(2):447\u2013454","journal-title":"Hum Reprod"},{"issue":"2","key":"10343_CR65","first-page":"69","volume":"19","author":"A Fallah","year":"2018","unstructured":"Fallah A, Mohammad-Hasani A, Colagar AH (2018) Zinc is an essential element for male fertility: a review of Zn roles in men\u2019s health, germination, sperm quality, and fertilization. J Reprod Infertil 19(2):69\u201381","journal-title":"J Reprod Infertil"},{"issue":"1","key":"10343_CR66","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/S0022-5347(17)34871-1","volume":"151","author":"HA Feldman","year":"1994","unstructured":"Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB (1994) Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 151(1):54\u201361","journal-title":"J Urol"},{"issue":"2","key":"10343_CR67","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1210\/jcem.87.2.8201","volume":"87","author":"HA Feldman","year":"2002","unstructured":"Feldman HA, Longcope C, Derby CA, Johannes CB, Araujo AB, Coviello AD, Bremner WJ, McKinlay JB (2002) Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. J Clin Endocrinol Metab 87(2):589\u2013598","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"10343_CR68","doi-asserted-by":"publisher","first-page":"3370","DOI":"10.1093\/humrep\/det392","volume":"28","author":"A Ferlin","year":"2013","unstructured":"Ferlin A, Rampazzo E, Rocca MS, Keppel S, Frigo AC, De Rossi A, Foresta C (2013) In young men sperm telomere length is related to sperm number and parental age. Hum Reprod 28(12):3370\u20133376","journal-title":"Hum Reprod"},{"issue":"3","key":"10343_CR69","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1095\/biolreprod64.3.974","volume":"64","author":"M Ferrini","year":"2001","unstructured":"Ferrini M, Magee TR, Vernet D, Rajfer J, Gonz\u00e1lez-Cadavid NF (2001) Aging-related expression of inducible nitric oxide synthase and markers of tissue damage in the rat penis. Biol Reprod 64(3):974\u2013982","journal-title":"Biol Reprod"},{"issue":"5","key":"10343_CR70","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/S0015-0282(16)58278-8","volume":"65","author":"H Fisch","year":"1996","unstructured":"Fisch H, Goluboff ET, Olson JH, Feldshuh J, Broder SJ, Barad DH (1996) Semen analyses in 1,283 men from the United States over a 25-year period: no decline in quality. Fertil Steril 65(5):1009\u20131014","journal-title":"Fertil Steril"},{"issue":"5","key":"10343_CR71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.33425\/2641-4317.1206","volume":"7","author":"G Galli Carminati","year":"2024","unstructured":"Galli Carminati G, Carminati F, Demongeot J (2024) A gender-related interpretation of human reproductive behavior. Int J Psychiatr Res 7(5):1\u201320","journal-title":"Int J Psychiatr Res"},{"issue":"1","key":"10343_CR72","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3390\/ijms20010031","volume":"20","author":"A Garc\u00eda-Rodr\u00edguez","year":"2018","unstructured":"Garc\u00eda-Rodr\u00edguez A, Gos\u00e1lvez J, Agarwal A, Roy R, Johnston S (2018) DNA damage and repair in human reproductive cells. Int J Mol Sci 20(1):31","journal-title":"Int J Mol Sci"},{"issue":"32","key":"10343_CR73","doi-asserted-by":"publisher","first-page":"53804","DOI":"10.18632\/oncotarget.17479","volume":"8","author":"SQ Ge","year":"2017","unstructured":"Ge SQ, Lin SL, Zhao ZH, Sun QY (2017) Epigenetic dynamics and interplay during spermatogenesis and embryogenesis: implications for male fertility and offspring health. Oncotarget 8(32):53804","journal-title":"Oncotarget"},{"key":"10343_CR74","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/bs.vh.2022.10.008","volume":"121","author":"A G\u0119gotek","year":"2023","unstructured":"G\u0119gotek A, Skrzydlewska E (2023) Ascorbic acid as antioxidant. Vitam Horm 121:247\u2013270","journal-title":"Vitam Horm"},{"key":"10343_CR75","doi-asserted-by":"crossref","unstructured":"Gerasymchuk, M., 2021. Genomic instability and aging: Causes and consequences. In\u00a0Genome Stability\u00a0(Second edition), Academic Press","DOI":"10.1016\/B978-0-323-85679-9.00028-3"},{"issue":"2","key":"10343_CR76","doi-asserted-by":"publisher","DOI":"10.1111\/and.12869","volume":"50","author":"AA Ghafarizadeh","year":"2018","unstructured":"Ghafarizadeh AA, Vaezi G, Shariatzadeh MA, Malekirad AA (2018) Effect of in vitro selenium supplementation on sperm quality in asthenoteratozoospermic men. Andrologia 50(2):e12869","journal-title":"Andrologia"},{"issue":"1","key":"10343_CR77","doi-asserted-by":"publisher","DOI":"10.1111\/and.13891","volume":"53","author":"AA Ghafarizadeh","year":"2021","unstructured":"Ghafarizadeh AA, Malmir M, Naderi Noreini S, Faraji T, Ebrahimi Z (2021) The effect of vitamin E on sperm motility and viability in asthenoteratozoospermic men: in vitro study. Andrologia 53(1):e13891","journal-title":"Andrologia"},{"issue":"2","key":"10343_CR78","first-page":"51","volume":"3","author":"NF Gonzalez-Cadavid","year":"1999","unstructured":"Gonzalez-Cadavid NF, Ignarro LJ, Rajfer J (1999) Nitric oxide and the cyclic GMP system in the penis. Mol Urol 3(2):51\u201359","journal-title":"Mol Urol"},{"key":"10343_CR79","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s10815-016-0663-y","volume":"33","author":"S Gunes","year":"2016","unstructured":"Gunes S, Hekim GNT, Arslan MA, Asci R (2016) Effects of aging on the male reproductive system. J Assist Reprod Genet 33:441\u2013454","journal-title":"J Assist Reprod Genet"},{"key":"10343_CR80","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00435","volume":"10","author":"AP Gureev","year":"2019","unstructured":"Gureev AP, Shaforostova EA, Popov VN (2019) Regulation of mitochondrial biogenesis as a way for active longevity: interaction between the Nrf2 and PGC-1\u03b1 signaling pathways. Front Genet 10:435733","journal-title":"Front Genet"},{"issue":"2","key":"10343_CR81","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3390\/biology8020048","volume":"8","author":"RH Haas","year":"2019","unstructured":"Haas RH (2019) Mitochondrial dysfunction in aging and diseases of aging. Biology 8(2):48","journal-title":"Biology"},{"key":"10343_CR82","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0074-7696(04)33005-6","volume":"233","author":"SG Haider","year":"2004","unstructured":"Haider SG (2004) Cell biology of Leydig cells in the testis. Int Rev Cytol 233:181\u2013241","journal-title":"Int Rev Cytol"},{"issue":"Supplement_1","key":"10343_CR83","doi-asserted-by":"publisher","first-page":"deac107-002","DOI":"10.1093\/humrep\/deac107.002","volume":"37","author":"M Hamed","year":"2022","unstructured":"Hamed M, Akhigbe R (2022) P-002 zinc restores testicular integrity and function in HAART-treated male Wistar rats via modulation of Nrf2\/NFkB pathway and downregulation of caspase 3 signaling. Hum Reprod 37(Supplement_1):deac107-002","journal-title":"Hum Reprod"},{"key":"10343_CR84","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110233","volume":"368","author":"MA Hamed","year":"2022","unstructured":"Hamed MA, Akhigbe RE, Aremu AO, Odetayo AF (2022a) Zinc normalizes hepatic lipid handling via modulation of ADA\/XO\/UA pathway and caspase 3 signaling in highly active antiretroviral therapy-treated Wistar rats. Chem Biol Interact 368:110233","journal-title":"Chem Biol Interact"},{"key":"10343_CR85","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112765","volume":"148","author":"MA Hamed","year":"2022","unstructured":"Hamed MA, Akhigbe TM, Akhigbe RE, Aremu AO, Oyedokun PA, Gbadamosi JA, Anifowose PE, Adewole MA, Aboyeji OO, Yisau HO, Tajudeen GO (2022b) Glutamine restores testicular glutathione-dependent antioxidant defense and upregulates NO\/cGMP signaling in sleep deprivation-induced reproductive dysfunction in rats. Biomed Pharmacother 148:112765","journal-title":"Biomed Pharmacother"},{"key":"10343_CR86","doi-asserted-by":"publisher","first-page":"1227836","DOI":"10.3389\/fendo.2023.1227836","volume":"14","author":"MA Hamed","year":"2023","unstructured":"Hamed MA, Akhigbe TM, Adeogun AE, Adesoye OB, Akhigbe RE (2023) Impact of organophosphate pesticides exposure on human semen parameters and testosterone: a systematic review and meta-analysis. Front Endocrinol 14:1227836","journal-title":"Front Endocrinol"},{"issue":"2","key":"10343_CR87","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.stem.2014.04.006","volume":"15","author":"SS Hammoud","year":"2014","unstructured":"Hammoud SS, Low DH, Yi C, Carrell DT, Guccione E, Cairns BR (2014) Chromatin and transcription transitions of mammalian adult germline stem cells and spermatogenesis. Cell Stem Cell 15(2):239\u2013253","journal-title":"Cell Stem Cell"},{"key":"10343_CR88","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.152780","volume":"456","author":"X Han","year":"2021","unstructured":"Han X, Huang Q (2021) Environmental pollutants exposure and male reproductive toxicity: the role of epigenetic modifications. Toxicology 456:152780","journal-title":"Toxicology"},{"key":"10343_CR89","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1210\/jcem.86.2.7219","volume":"86","author":"SM Harman","year":"2001","unstructured":"Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR (2001) Longitudinal effects of aging on serum total and free testosterone levels in healthy men, Baltimore Longitudinal Study of Aging. J Endocrinol Metab 86:724\u2013731","journal-title":"J Endocrinol Metab"},{"issue":"6","key":"10343_CR90","doi-asserted-by":"publisher","first-page":"5089","DOI":"10.1007\/s11033-022-07219-1","volume":"49","author":"M Hemagirri","year":"2022","unstructured":"Hemagirri M, Sasidharan S (2022) Biology of aging: oxidative stress and RNA oxidation. Mol Biol Rep 49(6):5089\u20135105","journal-title":"Mol Biol Rep"},{"key":"10343_CR91","volume-title":"Male Infertility","author":"R Henkel","year":"2020","unstructured":"Henkel R, Leisegang K (2020) Origins of Sperm DNA Damage. In: Parekattil S, Esteves S, Agarwal A (eds) Male Infertility. Springer, Cham"},{"issue":"1","key":"10343_CR92","doi-asserted-by":"publisher","DOI":"10.1111\/and.13162","volume":"51","author":"R Henkel","year":"2019","unstructured":"Henkel R, Sandhu IS, Agarwal A (2019) The excessive use of antioxidant therapy: a possible cause of male infertility? Andrologia 51(1):e13162","journal-title":"Andrologia"},{"issue":"1","key":"10343_CR93","first-page":"146","volume":"16","author":"XC Huang","year":"2024","unstructured":"Huang XC, Jiang YN, Bao HJ, Wang JL, Lin RJ, Yuan J, Xian JY, Zhao Y, Chen S (2024) Role and mechanism of epigenetic regulation in the aging of germ cells: prospects for targeted interventions. Aging Dis 16(1):146","journal-title":"Aging Dis"},{"key":"10343_CR94","doi-asserted-by":"publisher","first-page":"1070692","DOI":"10.3389\/fendo.2023.1070692","volume":"14","author":"T Hussain","year":"2023","unstructured":"Hussain T, Kandeel M, Metwally E, Murtaza G, Kalhoro DH, Yin Y, Tan B, Chughtai MI, Yaseen A, Afzal A, Kalhoro MS (2023) Unraveling the harmful effect of oxidative stress on male fertility: a mechanistic insight. Front Endocrinol 14:1070692","journal-title":"Front Endocrinol"},{"issue":"4","key":"10343_CR95","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ajme.2017.09.001","volume":"54","author":"OM Ighodaro","year":"2018","unstructured":"Ighodaro OM, Akinloye OA (2018) First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): their fundamental role in the entire antioxidant defence grid. Alexandria J Med 54(4):287\u2013293","journal-title":"Alexandria J Med"},{"issue":"1","key":"10343_CR96","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12958-019-0468-9","volume":"17","author":"R Jannatifar","year":"2019","unstructured":"Jannatifar R, Parivar K, Roodbari NH, Nasr-Esfahani MH (2019) Effects of N-acetyl-cysteine supplementation on sperm quality, chromatin integrity and level of oxidative stress in infertile men. Reprod Biol Endocrinol 17(1):24","journal-title":"Reprod Biol Endocrinol"},{"key":"10343_CR97","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/S0378-4320(00)00108-1","volume":"60","author":"L Johnson","year":"2000","unstructured":"Johnson L, Varner DD, Roberts ME, Smith TL, Keillor GE, Scrutchfield WL (2000) Efficiency of spermatogenesis: a comparative approach. Anim Reprod Sci 60:471\u2013480","journal-title":"Anim Reprod Sci"},{"issue":"1\u20132","key":"10343_CR98","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.anireprosci.2007.11.029","volume":"105","author":"L Johnson","year":"2008","unstructured":"Johnson L, Thompson DL Jr, Varner DD (2008) Role of Sertoli cell number and function on regulation of spermatogenesis. Anim Reprod Sci 105(1\u20132):23\u201351","journal-title":"Anim Reprod Sci"},{"key":"10343_CR99","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101125","volume":"62","author":"H Kahroba","year":"2020","unstructured":"Kahroba H, Sadeghzadeh H, Wilson III DM, Maadi H, Samadi N, Hejazi MS, Farajpour H, Onari BN, Sadeghi MR (2020) DNA damage repair response in mesenchymal stromal cells: from cellular senescence and aging to apoptosis and differentiation ability. Ageing Res Rev 62:101125","journal-title":"Ageing Res Rev"},{"issue":"10","key":"10343_CR100","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.3390\/medicina59101769","volume":"59","author":"A Kaltsas","year":"2023","unstructured":"Kaltsas A (2023) Oxidative stress and male infertility: the protective role of antioxidants. Medicina (Kaunas) 59(10):1769","journal-title":"Medicina (Kaunas)"},{"issue":"12","key":"10343_CR101","doi-asserted-by":"publisher","first-page":"3206","DOI":"10.3390\/biomedicines10123206","volume":"10","author":"N Karunasinghe","year":"2022","unstructured":"Karunasinghe N (2022) Zinc in prostate health and disease: a mini review. Biomedicines 10(12):3206","journal-title":"Biomedicines"},{"issue":"6","key":"10343_CR102","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1210\/er.2004-0013","volume":"26","author":"JM Kaufman","year":"2005","unstructured":"Kaufman JM, Vermeulen A (2005) The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev 26(6):833\u2013876","journal-title":"Endocr Rev"},{"issue":"4","key":"10343_CR103","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1111\/acel.12601","volume":"16","author":"SS Khan","year":"2017","unstructured":"Khan SS, Singer BD, Vaughan DE (2017) Molecular and physiological manifestations and measurement of aging in humans. Aging Cell 16(4):624\u2013633","journal-title":"Aging Cell"},{"issue":"8","key":"10343_CR104","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1007\/s10815-022-02545-6","volume":"39","author":"Z Khosravizadeh","year":"2022","unstructured":"Khosravizadeh Z, Khodamoradi K, Rashidi Z, Jahromi M, Shiri E, Salehi E, Talebi A (2022) Sperm cryopreservation and DNA methylation: possible implications for ART success and the health of offspring. J Assist Reprod Genet 39(8):1815\u20131824","journal-title":"J Assist Reprod Genet"},{"issue":"4","key":"10343_CR105","doi-asserted-by":"publisher","first-page":"882","DOI":"10.5534\/wjmh.220100","volume":"41","author":"KH Kim","year":"2023","unstructured":"Kim KH, Park MJ, Park NC, Park HJ (2023) Effect of N-acetyl-L-cysteine on testicular tissue in busulfan-induced dysfunction in the male reproductive system. World J Mens Health 41(4):882","journal-title":"World J Mens Health"},{"key":"10343_CR106","volume-title":"Developmental Origins of Health and Disease (DOHaD)","author":"R Kimura","year":"2018","unstructured":"Kimura R, Yoshizaki K, Osumi N (2018) Risk of Neurodevelopmental Disease by Paternal Aging: A Possible Influence of Epigenetic Alteration in Sperm. In: Kubota T, Fukuoka H (eds) Developmental Origins of Health and Disease (DOHaD). Advances in Experimental Medicine and Biology, Springer, Singapore"},{"issue":"11","key":"10343_CR107","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.1007\/s10815-021-02301-2","volume":"38","author":"JF Knudtson","year":"2021","unstructured":"Knudtson JF, Sun F, Coward RM, Hansen KR, Barnhart KT, Smith J, Legro RS, Diamond MP, Krawetz SA, Zhang H, Usadi R (2021) The relationship of plasma antioxidant levels to semen parameters: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. J Assist Reprod Genet 38(11):3005\u20133013","journal-title":"J Assist Reprod Genet"},{"issue":"5","key":"10343_CR108","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1007\/s43032-021-00795-w","volume":"29","author":"A Kowalczyk","year":"2022","unstructured":"Kowalczyk A (2022) The role of the natural antioxidant mechanism in sperm cells. Reprod Sci 29(5):1387\u20131394","journal-title":"Reprod Sci"},{"issue":"17","key":"10343_CR109","doi-asserted-by":"publisher","first-page":"3821","DOI":"10.3390\/nu15173821","volume":"15","author":"A Kulawik","year":"2023","unstructured":"Kulawik A, Cielecka-Piontek J, Zalewski P (2023) The importance of antioxidant activity for the health-promoting effect of lycopene. Nutrients 15(17):3821","journal-title":"Nutrients"},{"issue":"5","key":"10343_CR110","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.2337\/diacare.27.5.1036","volume":"27","author":"DE Laaksonen","year":"2004","unstructured":"Laaksonen DE, Niskanen L, Punnonen K, Nyyssonen K, Tuomainen TP, Valkonen VP, Salonen JT (2004) Testosterone and sex hormone\u2013binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care 27(5):1036\u20131041","journal-title":"Diabetes Care"},{"issue":"6","key":"10343_CR111","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1111\/joim.12055","volume":"273","author":"M Lagouge","year":"2013","unstructured":"Lagouge M, Larsson NG (2013) The role of mitochondrial DNA mutations and free radicals in disease and ageing. J Intern Med 273(6):529\u2013543","journal-title":"J Intern Med"},{"issue":"2","key":"10343_CR112","first-page":"109","volume":"26","author":"MR Lakpour","year":"2025","unstructured":"Lakpour MR, Aflatoonian R, Sadighi Gilani MA, Hajihosseini R, Sabbaghian M (2025) Altered expression of Toll-like receptors and key signaling genes in Sertoli cells of azoospermic patients. J Reprod Infertil 26(2):109\u2013118","journal-title":"J Reprod Infertil"},{"issue":"10","key":"10343_CR113","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13242","volume":"19","author":"S Laurentino","year":"2020","unstructured":"Laurentino S, Cremers JF, Horsthemke B, T\u00fcttelmann F, Czeloth K, Zitzmann M, Cremers J-F, Pohl E, Rahmann S, Schr\u00f6der C, Berres S, Redmann K, Krallmann C, Schlatt S, Kliesch S, Gromoll J (2020) A germ cell-specific ageing pattern in otherwise healthy men. Aging Cell 19(10):e13242","journal-title":"Aging Cell"},{"issue":"6","key":"10343_CR114","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1016\/j.fertnstert.2003.10.034","volume":"81","author":"A Lenzi","year":"2004","unstructured":"Lenzi A, Sgro P, Salacone P, Paoli D, Gilio B, Lombardo F, Santulli M, Agarwal A, Gandini L (2004) A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. Fertil Steril 81(6):1578\u20131584","journal-title":"Fertil Steril"},{"issue":"2","key":"10343_CR115","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/j.1439-0272.2007.00761.x","volume":"39","author":"E Levitas","year":"2007","unstructured":"Levitas E, Lunenfeld E, Weisz N, Friger M, Potashnik G (2007) Relationship between age and semen parameters in men with normal sperm concentration: analysis of 6022 semen samples. Andrologia 39(2):45\u201350","journal-title":"Andrologia"},{"issue":"1","key":"10343_CR116","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41420-022-01073-7","volume":"8","author":"X Li","year":"2022","unstructured":"Li X, Xu M, Shen J, Li Y, Lin S, Zhu M, Pang Q, Tan X, Tang J (2022a) Sorafenib inhibits LPS-induced inflammation by regulating Lyn-MAPK-NF-kB\/AP-1 pathway and TLR4 expression. Cell Death Discov 8(1):281","journal-title":"Cell Death Discov"},{"key":"10343_CR117","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S380785","author":"Y Li","year":"2022","unstructured":"Li Y, Zhu J, Zhao X, Sun Y, Xu F, Xu S, Shang X (2022b) Oral lycopene administration attenuates inflammation and oxidative stress by regulating plasma lipids in rats with lipopolysaccharide-induced epididymitis. J Inflamm Res. https:\/\/doi.org\/10.2147\/JIR.S380785","journal-title":"J Inflamm Res"},{"key":"10343_CR118","unstructured":"Liao, J., 2017.\u00a0Delineating Transcriptional and Epigenetic Regulations in Normal and Ageing Spermatogonial Stem Cells\u00a0(Doctoral dissertation, The Chinese University of Hong Kong (Hong Kong))."},{"issue":"2","key":"10343_CR119","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12487","volume":"26","author":"Y Liu","year":"2019","unstructured":"Liu Y, Bloom SI, Donato AJ (2019) The role of senescence, telomere dysfunction and shelterin in vascular aging. Microcirculation 26(2):e12487","journal-title":"Microcirculation"},{"issue":"5","key":"10343_CR120","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1016\/j.fertnstert.2009.05.036","volume":"92","author":"M Luna","year":"2009","unstructured":"Luna M, Finkler E, Barritt J, Bar-Chama N, Sandler B, Copperman AB, Grunfeld L (2009) Paternal age and assisted reproductive technology outcome in ovum recipients. Fertil Steril 92(5):1772\u20131775","journal-title":"Fertil Steril"},{"key":"10343_CR121","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/j.1939-4640.2005.tb02868.x","volume":"26","author":"L Luo","year":"2005","unstructured":"Luo L, Chen H, Zirkin BR (2005) Temporal relationships among testosterone production, steroidogenic acute regulatory protein (StAR), and P450 side-chain cleavage enzyme (P450scc) during Leydig cell aging. J Androl 26:25\u201331","journal-title":"J Androl"},{"issue":"10","key":"10343_CR122","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10102335","volume":"10","author":"AY Lupatov","year":"2022","unstructured":"Lupatov AY, Yarygin KN (2022) Telomeres and telomerase in the control of stem cells. Biomedicines 10(10):2335","journal-title":"Biomedicines"},{"key":"10343_CR123","volume":"5","author":"M Malmir","year":"2021","unstructured":"Malmir M, Mehranjani MS, Faraji T, Noreini SN (2021) Antioxidant effect of vitamin E on the male rat reproductive system by a high oral dose of Bisphenol-A. Toxicol Res Appl 5:23978473211005562","journal-title":"Toxicol Res Appl"},{"issue":"1","key":"10343_CR124","first-page":"1","volume":"16","author":"ET Marzouni","year":"2022","unstructured":"Marzouni ET, Ilkhani H, Harchegani AB, Shafaghatian H, Layali I, Shahriary A (2022) Epigenetic modifications, a new approach to male infertility etiology: a review. Int J Fertil Steril 16(1):1","journal-title":"Int J Fertil Steril"},{"issue":"18","key":"10343_CR125","doi-asserted-by":"publisher","first-page":"5796","DOI":"10.3390\/jcm12185796","volume":"12","author":"FG Mateus","year":"2023","unstructured":"Mateus FG, Moreira S, Martins AD, Oliveira PF, Alves MG, Pereira MDL (2023) L-carnitine and male fertility: is supplementation beneficial? J Clin Med 12(18):5796","journal-title":"J Clin Med"},{"key":"10343_CR126","doi-asserted-by":"publisher","first-page":"M76","DOI":"10.1093\/gerona\/57.2.M76","volume":"57","author":"AM Matsumoto","year":"2002","unstructured":"Matsumoto AM (2002) Andropause: clinical implications of the decline in serum testosterone levels with aging in men. J Gerontol A Biol Sci Med Sci 57:M76\u2013M99","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"11","key":"10343_CR127","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113114","volume":"10","author":"ME Matzkin","year":"2021","unstructured":"Matzkin ME, Calandra RS, Rossi SP, Bartke A, Frungieri MB (2021) Hallmarks of testicular aging: the challenge of anti-inflammatory and antioxidant therapies using natural and\/or pharmacological compounds to improve the physiopathological status of the aged male gonad. Cells 10(11):3114","journal-title":"Cells"},{"issue":"9","key":"10343_CR129","doi-asserted-by":"publisher","first-page":"3256","DOI":"10.3390\/nu13093256","volume":"13","author":"A Mojadadi","year":"2021","unstructured":"Mojadadi A, Au A, Salah W, Witting P, Ahmad G (2021) Role for selenium in metabolic homeostasis and human reproduction. Nutrients 13(9):3256","journal-title":"Nutrients"},{"key":"10343_CR130","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S16275","author":"MK Moslemi","year":"2011","unstructured":"Moslemi MK, Tavanbakhsh S (2011) Selenium\u2013vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate. Int J Gen Med. https:\/\/doi.org\/10.2147\/IJGM.S16275","journal-title":"Int J Gen Med"},{"key":"10343_CR131","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2023.1134244","volume":"10","author":"SH Mousavi Esfiokhi","year":"2023","unstructured":"Mousavi Esfiokhi SH, Norouzian MA, Najafi A (2023) Effect of different sources of dietary zinc on sperm quality and oxidative parameters. Front Vet Sci 10:1134244","journal-title":"Front Vet Sci"},{"key":"10343_CR132","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.mito.2014.03.007","volume":"17","author":"M Muftuoglu","year":"2014","unstructured":"Muftuoglu M, Mori MP, de Souza-Pinto NC (2014) Formation and repair of oxidative damage in the mitochondrial DNA. Mitochondrion 17:164\u2013181","journal-title":"Mitochondrion"},{"key":"10343_CR133","doi-asserted-by":"crossref","unstructured":"Mutalip SSM (2020) Vitamin E and reproductive health. In:\u00a0Molecular Nutrition (Edited by Vinood B. Patel)","DOI":"10.1016\/B978-0-12-811907-5.00025-7"},{"issue":"5","key":"10343_CR134","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1089\/bio.2020.0025","volume":"18","author":"IH Nery","year":"2020","unstructured":"Nery IH, Araujo Silva RA, Souza HM, Arruda LC, Monteiro MM, Seal DC, Silva GR, Silva TM, Carneiro GF, Batista AM, C\u00e2mara DR (2020) Effects of l-carnitine on equine semen quality during liquid storage. Biopreserv Biobank 18(5):403\u2013408","journal-title":"Biopreserv Biobank"},{"issue":"1","key":"10343_CR135","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1093\/humupd\/dmp027","volume":"16","author":"E Nieschlag","year":"2010","unstructured":"Nieschlag E (2010) Paternal age and reproduction. Hum Reprod Update 16(1):65\u201379","journal-title":"Hum Reprod Update"},{"issue":"12","key":"10343_CR137","doi-asserted-by":"publisher","first-page":"3203","DOI":"10.1002\/ptr.6493","volume":"33","author":"M Nouri","year":"2019","unstructured":"Nouri M, Amani R, Nasr-Esfahani M, Tarrahi MJ (2019) The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: a randomized, double-blind, placebo-controlled clinical trial. Phytother Res 33(12):3203\u20133211","journal-title":"Phytother Res"},{"issue":"2","key":"10343_CR138","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3390\/antiox9020134","volume":"9","author":"K Nowicka-Bauer","year":"2020","unstructured":"Nowicka-Bauer K, Nixon B (2020) Molecular changes induced by oxidative stress that impair human sperm motility. Antioxidants 9(2):134","journal-title":"Antioxidants"},{"key":"10343_CR139","doi-asserted-by":"publisher","first-page":"1329564","DOI":"10.3389\/fendo.2023.1329564","volume":"14","author":"AF Odetayo","year":"2024","unstructured":"Odetayo AF, Akhigbe RE, Bassey GE, Hamed MA, Olayaki LA (2024) Impact of stress on male fertility: role of gonadotropin inhibitory hormone. Front Endocrinol 14:1329564","journal-title":"Front Endocrinol"},{"issue":"4","key":"10343_CR140","volume":"18","author":"AA Oladipo","year":"2025","unstructured":"Oladipo AA, Adisa VI, Ogunkola BD, Oladapo OM, Ajeigbe SB, Adedoyin OO, Akhigbe TM, Akhigbe RE (2025) Impact of electromagnetic radiation on human reproduction health: causes, consequences, and potential therapeutic approaches. J Radiat Res Appl Sci 18(4):102010","journal-title":"J Radiat Res Appl Sci"},{"issue":"2","key":"10343_CR141","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1095\/biolreprod.114.124008","volume":"92","author":"S Ozturk","year":"2015","unstructured":"Ozturk S (2015) Telomerase activity and telomere length in male germ cells. Biol Reprod 92(2):53\u201361","journal-title":"Biol Reprod"},{"issue":"2","key":"10343_CR142","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1093\/humrep\/dey357","volume":"34","author":"D Paoli","year":"2019","unstructured":"Paoli D, Pecora G, Pallotti F, Faja F, Pelloni M, Lenzi A, Lombardo F (2019) Cytological and molecular aspects of the ageing sperm. Hum Reprod 34(2):218\u2013227","journal-title":"Hum Reprod"},{"issue":"6","key":"10343_CR143","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1095\/biolreprod.111.094219","volume":"85","author":"C Paul","year":"2011","unstructured":"Paul C, Nagano M, Robaire B (2011) Aging results in differential regulation of DNA repair pathways in pachytene spermatocytes in the Brown Norway rat. Biol Reprod 85(6):1269\u20131278","journal-title":"Biol Reprod"},{"issue":"4","key":"10343_CR144","doi-asserted-by":"publisher","first-page":"R89","DOI":"10.1530\/REP-20-0633","volume":"161","author":"E Pohl","year":"2021","unstructured":"Pohl E, Gromoll J, Wistuba J, Laurentino S (2021) Healthy ageing and spermatogenesis. Reproduction 161(4):R89\u2013R101","journal-title":"Reproduction"},{"issue":"9","key":"10343_CR145","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.3390\/antiox10091441","volume":"10","author":"JC Ribeiro","year":"2021","unstructured":"Ribeiro JC, Braga PC, Martins AD, Silva BM, Alves MG, Oliveira PF (2021) Antioxidants present in reproductive tract fluids and their relevance for fertility. Antioxidants 10(9):1441","journal-title":"Antioxidants"},{"key":"10343_CR146","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.689624","volume":"9","author":"JC Rotondo","year":"2021","unstructured":"Rotondo JC, Lanzillotti C, Mazziotta C, Tognon M, Martini F (2021) Epigenetics of male infertility: the role of DNA methylation. Front Cell Dev Biol 9:689624","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"10343_CR147","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3390\/antiox9020094","volume":"9","author":"M Rudzi\u0144ska","year":"2020","unstructured":"Rudzi\u0144ska M, Parodi A, Balakireva AV, Chepikova OE, Venanzi FM, Zamyatnin AA Jr (2020) Cellular aging characteristics and their association with age-related disorders. Antioxidants 9(2):94","journal-title":"Antioxidants"},{"issue":"1","key":"10343_CR148","volume":"2019","author":"E Saddein","year":"2019","unstructured":"Saddein E, Haghpanah T, Nematollahi-Mahani SN, Seyedi F, Ezzatabadipour M (2019) Preventative effects of vitamin E on testicular damage and sperm parameters in the first-generation mice pups due to pre-and postnatal mancozeb exposure. J Toxicol 2019(1):4763684","journal-title":"J Toxicol"},{"issue":"2","key":"10343_CR149","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.juro.2008.10.015","volume":"181","author":"MR Safarinejad","year":"2009","unstructured":"Safarinejad MR, Safarinejad S (2009) Efficacy of selenium and\/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol 181(2):741\u2013751","journal-title":"J Urol"},{"key":"10343_CR150","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.89453","author":"S Sahoo","year":"2025","unstructured":"Sahoo S, Das A, Dash R, Behera A, Mishra N (2025) The psychological impact of male infertility: a narrative review. Cureus. https:\/\/doi.org\/10.7759\/cureus.89453","journal-title":"Cureus"},{"key":"10343_CR151","doi-asserted-by":"publisher","first-page":"7","DOI":"10.9734\/bpi\/rtcms\/v8\/2412E","volume":"8","author":"E Salabas","year":"2021","unstructured":"Salabas E, Karabulut S, Yazar S, Irez T (2021) Effects of environmental pollutants on the male reproductive system. Res Trends Challenges Med Sci 8:7\u201338","journal-title":"Res Trends Challenges Med Sci"},{"issue":"6","key":"10343_CR152","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1093\/advances\/nmy057","volume":"9","author":"A Salas-Huetos","year":"2018","unstructured":"Salas-Huetos A, Rosique-Esteban N, Becerra-Tom\u00e1s N, Vizmanos B, Bull\u00f3 M, Salas-Salvad\u00f3 J (2018) The effect of nutrients and dietary supplements on sperm quality parameters: a systematic review and meta-analysis of randomized clinical trials. Adv Nutr 9(6):833\u2013848","journal-title":"Adv Nutr"},{"issue":"6","key":"10343_CR153","doi-asserted-by":"publisher","first-page":"874","DOI":"10.3390\/antiox10060874","volume":"10","author":"G Salvio","year":"2021","unstructured":"Salvio G, Cutini M, Ciarloni A, Giovannini L, Perrone M, Balercia G (2021) Coenzyme Q10 and male infertility: a systematic review. Antioxidants 10(6):874","journal-title":"Antioxidants"},{"issue":"6","key":"10343_CR154","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1093\/gerona\/gly082","volume":"74","author":"J Santiago","year":"2019","unstructured":"Santiago J, Silva JV, Alves MG, Oliveira PF, Fardilha M (2019) Testicular aging: an overview of ultrastructural, cellular, and molecular alterations. J Gerontol: Series A 74(6):860\u2013871","journal-title":"J Gerontol: Series A"},{"issue":"5","key":"10343_CR155","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1080\/13685538.2019.1573220","volume":"23","author":"HO Santos","year":"2019","unstructured":"Santos HO, Teixeira FJ (2019) Use of medicinal doses of zinc as a safe and efficient coadjutant in the treatment of male hypogonadism. Aging Male 23(5):669\u2013678","journal-title":"Aging Male"},{"issue":"1","key":"10343_CR156","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1093\/humrep\/del338","volume":"22","author":"TE Schmid","year":"2007","unstructured":"Schmid TE, Eskenazi B, Baumgartner A, Marchetti F, Young S, Weldon R, Anderson D, Wyrobek AJ (2007) The effects of male age on sperm DNA damage in healthy non-smokers. Hum Reprod 22(1):180\u2013187","journal-title":"Hum Reprod"},{"key":"10343_CR157","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2023.105490","volume":"164","author":"V Sharma","year":"2023","unstructured":"Sharma V, Mehdi MM (2023) Oxidative stress, inflammation and hormesis: the role of dietary and lifestyle modifications on aging. Neurochem Int 164:105490","journal-title":"Neurochem Int"},{"issue":"3","key":"10343_CR158","first-page":"506","volume":"3","author":"RK Sharma","year":"2015","unstructured":"Sharma RK, Bhat RA, Goyal AK, Bhardwaj JK (2015) Germ cells apoptosis during spermatogenesis in mammals. J Entomol Zool Stud 3(3):506\u2013515","journal-title":"J Entomol Zool Stud"},{"issue":"11","key":"10343_CR159","doi-asserted-by":"publisher","DOI":"10.1111\/and.13432","volume":"51","author":"P Sharma","year":"2019","unstructured":"Sharma P, Ghanghas P, Kaushal N, Kaur J, Kaur P (2019) Epigenetics and oxidative stress: a twin-edged sword in spermatogenesis. Andrologia 51(11):e13432","journal-title":"Andrologia"},{"key":"10343_CR160","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.urology.2021.10.041","volume":"161","author":"AP Sharma","year":"2022","unstructured":"Sharma AP, Sharma G, Kumar R (2022) Systematic review and meta-analysis on effect of carnitine, coenzyme Q10 and selenium on pregnancy and semen parameters in couples with idiopathic male infertility. Urology 161:4\u201311","journal-title":"Urology"},{"issue":"5","key":"10343_CR161","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41580-021-00441-y","volume":"23","author":"M Shvedunova","year":"2022","unstructured":"Shvedunova M, Akhtar A (2022) Modulation of cellular processes by histone and non-histone protein acetylation. Nat Rev Mol Cell Biol 23(5):329\u2013349","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"10343_CR162","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare10030487","volume":"10","author":"S Sifuentes-Franco","year":"2022","unstructured":"Sifuentes-Franco S, S\u00e1nchez-Mac\u00edas DC, Carrillo-Ibarra S, Rivera-Vald\u00e9s JJ, Zu\u00f1iga LY, S\u00e1nchez-L\u00f3pez VA (2022) Antioxidant and anti-inflammatory effects of coenzyme Q10 supplementation on infectious diseases. Healthcare 10(3):487","journal-title":"Healthcare"},{"issue":"5","key":"10343_CR163","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1016\/j.fertnstert.2005.10.055","volume":"85","author":"M Sigman","year":"2006","unstructured":"Sigman M, Glass S, Campagnone J, Pryor JL (2006) Carnitine for the treatment of idiopathic asthenospermia: a randomized, double-blind, placebo-controlled trial. Fertil Steril 85(5):1409\u20131414","journal-title":"Fertil Steril"},{"issue":"3","key":"10343_CR164","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.arr.2010.11.002","volume":"10","author":"T Singh","year":"2011","unstructured":"Singh T, Newman AB (2011) Inflammatory markers in population studies of aging. Ageing Res Rev 10(3):319\u2013329","journal-title":"Ageing Res Rev"},{"issue":"2","key":"10343_CR165","first-page":"127","volume":"4","author":"P Sobhon","year":"2023","unstructured":"Sobhon P, Savedvanich G, Weerakiet S (2023) Oxidative stress and inflammation: the root causes of aging. Explorat Med 4(2):127\u2013156","journal-title":"Explorat Med"},{"issue":"7","key":"10343_CR166","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1016\/j.theriogenology.2004.10.003","volume":"63","author":"M S\u00f6nmez","year":"2005","unstructured":"S\u00f6nmez M, T\u00fcrk G, Y\u00fcce A (2005) The effect of ascorbic acid supplementation on sperm quality, lipid peroxidation and testosterone levels of male Wistar rats. Theriogenology 63(7):2063\u20132072","journal-title":"Theriogenology"},{"key":"10343_CR167","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.895044","volume":"13","author":"ILLD Souza","year":"2022","unstructured":"Souza ILLD, Ferreira EDS, Vasconcelos LHC, Cavalcante FDA, Silva BAD (2022) Erectile dysfunction: key role of cavernous smooth muscle cells. Front Pharmacol 13:895044","journal-title":"Front Pharmacol"},{"issue":"12","key":"10343_CR168","doi-asserted-by":"publisher","first-page":"398","DOI":"10.3390\/genes8120398","volume":"8","author":"S Srivastava","year":"2017","unstructured":"Srivastava S (2017) The mitochondrial basis of aging and age-related disorders. Genes 8(12):398","journal-title":"Genes"},{"issue":"5","key":"10343_CR169","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1002\/1873-3468.12902","volume":"592","author":"R Stefanatos","year":"2018","unstructured":"Stefanatos R, Sanz A (2018) The role of mitochondrial ROS in the aging brain. FEBS Lett 592(5):743\u2013758","journal-title":"FEBS Lett"},{"issue":"3","key":"10343_CR170","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.fertnstert.2019.11.008","volume":"113","author":"AZ Steiner","year":"2020","unstructured":"Steiner AZ, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Coward RM, Huang H (2020) The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Fertil Steril 113(3):552\u2013560","journal-title":"Fertil Steril"},{"issue":"220","key":"10343_CR171","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/978-3-319-30567-7_5","volume":"2016","author":"C Stival","year":"2016","unstructured":"Stival C, Puga Molina LDC, Paudel B, Buffone MG, Visconti PE, Krapf D (2016) Sperm capacitation and acrosome reaction in mammalian sperm. Adv Anat Embryol Cell Biol 2016(220):93\u2013106","journal-title":"Adv Anat Embryol Cell Biol"},{"issue":"1","key":"10343_CR172","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s13148-015-0155-4","volume":"7","author":"L Stuppia","year":"2015","unstructured":"Stuppia L, Franzago M, Ballerini P, Gatta V, Antonucci I (2015) Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health. Clin Epigenetics 7(1):120","journal-title":"Clin Epigenetics"},{"issue":"2","key":"10343_CR173","doi-asserted-by":"publisher","first-page":"612","DOI":"10.14336\/AD.2023.0621","volume":"15","author":"R Sun","year":"2024","unstructured":"Sun R, Feng J, Wang J (2024) Underlying mechanisms and treatment of cellular senescence-induced biological barrier interruption and related diseases. Aging Dis 15(2):612","journal-title":"Aging Dis"},{"key":"10343_CR174","unstructured":"Tanksley, P.T., 2020.\u00a0From age to aging: Biological age and its role in the criminal career\u00a0(Doctoral dissertation, University of Cincinnati)."},{"issue":"11","key":"10343_CR175","doi-asserted-by":"publisher","first-page":"3425","DOI":"10.3390\/ijms19113425","volume":"19","author":"C Tiffon","year":"2018","unstructured":"Tiffon C (2018) The impact of nutrition and environmental epigenetics on human health and disease. Int J Mol Sci 19(11):3425","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10343_CR176","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.ajhg.2019.06.005","volume":"105","author":"V Tiwari","year":"2019","unstructured":"Tiwari V, Wilson DM (2019) DNA damage and associated DNA repair defects in disease and premature aging. Am J Hum Genet 105(2):237\u2013257","journal-title":"Am J Hum Genet"},{"issue":"3","key":"10343_CR177","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3390\/biology10030241","volume":"10","author":"E Torres-Arce","year":"2021","unstructured":"Torres-Arce E, Vizmanos B, Babio N, Marquez-Sandoval F, Salas-Huetos A (2021) Dietary antioxidants in the treatment of male infertility: counteracting oxidative stress. Biology 10(3):241","journal-title":"Biology"},{"key":"10343_CR178","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2046-2395-3-2","volume":"3","author":"MC Velarde","year":"2014","unstructured":"Velarde MC (2014) Mitochondrial and sex steroid hormone crosstalk during aging. Longev Healthspan 3:1\u201310","journal-title":"Longev Healthspan"},{"issue":"12","key":"10343_CR180","doi-asserted-by":"publisher","first-page":"6491","DOI":"10.1073\/pnas.1916414117","volume":"117","author":"MY Vyssokikh","year":"2020","unstructured":"Vyssokikh MY, Holtze S, Averina OA, Lyamzaev KG, Panteleeva AA, Marey MV, Zinovkin RA, Severin FF, Skulachev MV, Fasel N, Hildebrandt TB (2020) Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program. Proc Natl Acad Sci U S A 117(12):6491\u20136501","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10343_CR181","volume":"15","author":"G Walke","year":"2023","unstructured":"Walke G, Gaurkar SS, Prasad R, Lohakare T, Wanjari M (2023) The impact of oxidative stress on male reproductive function: exploring the role of antioxidant supplementation. Cureus 15(7):e42583","journal-title":"Cureus"},{"key":"10343_CR182","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7150\/oncm.28210","volume":"4","author":"S Wang","year":"2019","unstructured":"Wang S, Madu CO, Lu Y (2019) Telomere and its role in diseases. Oncomedicine 4:1\u20139","journal-title":"Oncomedicine"},{"issue":"5","key":"10343_CR183","doi-asserted-by":"publisher","first-page":"519","DOI":"10.3390\/ph15050519","volume":"15","author":"JJ Wang","year":"2022","unstructured":"Wang JJ, Wang SX, Tehmina Feng (2022) Age-related decline of male fertility: mitochondrial dysfunction and the antioxidant interventions. Pharmaceuticals 15(5):519","journal-title":"Pharmaceuticals"},{"issue":"1","key":"10343_CR184","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.fertnstert.2010.06.039","volume":"95","author":"BW Whitcomb","year":"2011","unstructured":"Whitcomb BW, Turzanski-Fortner R, Richter KS, Kipersztok S, Stillman RJ, Levy MJ, Levens ED (2011) Contribution of male age to outcomes in assisted reproductive technologies. Fertil Steril 95(1):147\u2013151","journal-title":"Fertil Steril"},{"issue":"5","key":"10343_CR185","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026070","volume":"6","author":"AB Williams","year":"2016","unstructured":"Williams AB, Schumacher B (2016) p53 in the DNA-damage-repair process. Cold Spring Harb Perspect Med 6(5):a026070","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10343_CR186","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/978-3-030-05315-4_26","volume-title":"Vitamin E in Human Health","author":"D Wu","year":"2019","unstructured":"Wu D, Meydani SN (2019) Vitamin E, Immune Function, and Protection Against Infection. In: Weber P, Birringer M, Blumberg J, Eggersdorfer M, Frank J (eds) Vitamin E in Human Health. Humana Press, Cham, Nutrition and Health, pp 371\u2013384"},{"key":"10343_CR187","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.mito.2019.07.003","volume":"49","author":"Y Wu","year":"2019","unstructured":"Wu Y, Chen M, Jiang J (2019) Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling. Mitochondrion 49:35\u201345","journal-title":"Mitochondrion"},{"issue":"7","key":"10343_CR188","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.exger.2012.07.012","volume":"48","author":"BB Yeap","year":"2013","unstructured":"Yeap BB (2013) Hormones and health outcomes in aging men. Exp Gerontol 48(7):677\u2013681","journal-title":"Exp Gerontol"},{"issue":"5","key":"10343_CR189","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1016\/j.fct.2010.02.002","volume":"48","author":"MI Yousef","year":"2010","unstructured":"Yousef MI (2010) Vitamin E modulates reproductive toxicity of pyrethroid lambda-cyhalothrin in male rabbits. Food Chem Toxicol 48(5):1152\u20131159","journal-title":"Food Chem Toxicol"},{"issue":"9","key":"10343_CR191","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1111\/rda.13748","volume":"55","author":"PP Zhang","year":"2020","unstructured":"Zhang PP, Wang JJ, Li CY, Hao HS, Wang HY, Du WH, Pang YW, Zhao SJ, Zou HY, Hao T, Yang S (2020a) Protective effect of vitamin C and lycopene on the in vitro fertilization capacity of sex-sorted bull sperm by inhibiting the oxidative stress. Reprod Domest Anim 55(9):1103\u20131114","journal-title":"Reprod Domest Anim"},{"issue":"2","key":"10343_CR192","doi-asserted-by":"publisher","DOI":"10.1111\/and.13470","volume":"52","author":"X Zhang","year":"2020","unstructured":"Zhang X, Cui Y, Dong L, Sun M, Zhang Y (2020b) The efficacy of combined l-carnitine and l-acetyl carnitine in men with idiopathic oligoasthenoteratozoospermia: a systematic review and meta-analysis. Andrologia 52(2):e13470","journal-title":"Andrologia"},{"key":"10343_CR193","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.dnarep.2018.08.027","volume":"70","author":"Y Zheng","year":"2018","unstructured":"Zheng Y, Lei Q, Jongejan A, Mulder CL, van Daalen SK, Mastenbroek S, Hwang G, Jordan PW, Repping S, Hamer G (2018) The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells. DNA Repair 70:55\u201366","journal-title":"DNA Repair"},{"issue":"1","key":"10343_CR194","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10522-018-9769-1","volume":"20","author":"Y Zhu","year":"2019","unstructured":"Zhu Y, Liu X, Ding X, Wang F, Geng X (2019) Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction. Biogerontology 20(1):1\u201316","journal-title":"Biogerontology"},{"issue":"4","key":"10343_CR195","first-page":"145","volume":"6","author":"M Zubair","year":"2017","unstructured":"Zubair M (2017) Effects of dietary vitamin E on male reproductive system. Asian Pac J Reprod 6(4):145\u2013150","journal-title":"Asian Pac J Reprod"},{"issue":"18","key":"10343_CR196","doi-asserted-by":"publisher","first-page":"4472","DOI":"10.3390\/ijms20184472","volume":"20","author":"L Zuo","year":"2019","unstructured":"Zuo L, Prather ER, Stetskiv M, Garrison DE, Meade JR, Peace TI, Zhou T (2019) Inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments. Int J Mol Sci 20(18):4472","journal-title":"Int J Mol Sci"}],"container-title":["Biogerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-025-10343-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10522-025-10343-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-025-10343-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T10:02:16Z","timestamp":1764583336000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10522-025-10343-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":192,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10343"],"URL":"https:\/\/doi.org\/10.1007\/s10522-025-10343-7","relation":{},"ISSN":["1389-5729","1573-6768"],"issn-type":[{"value":"1389-5729","type":"print"},{"value":"1573-6768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,31]]},"assertion":[{"value":"13 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"N\/A","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"198"}}