{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:28:56Z","timestamp":1793158136724,"version":"4.5.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Stichting Alzheimer Onderzoek SAO-FRA","award":["20230041"],"award-info":[{"award-number":["20230041"]}]},{"name":"University of Antwerp TOP-BOF project","award":["35018"],"award-info":[{"award-number":["35018"]}]},{"name":"University of Antwerp TOP-BOF project","award":["35020"],"award-info":[{"award-number":["35020"]}]},{"name":"The Research Foundation Flanders project","award":["G017618N"],"award-info":[{"award-number":["G017618N"]}]},{"name":"International Research Infrastructure","award":["I000123N"],"award-info":[{"award-number":["I000123N"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biogerontology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10522-026-10385-5","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T14:43:03Z","timestamp":1768056183000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Low-grade mucosal inflammation in aged senescence-accelerated mouse-prone 8 mice blunts epithelial barrier recovery after dextran sodium sulphate-induced chronic colitis"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6424-2399","authenticated-orcid":false,"given":"Rosanne","family":"Verboven","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2214-2806","authenticated-orcid":false,"given":"Peter","family":"Verstraelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3694-6860","authenticated-orcid":false,"given":"Nouchin","family":"De Loose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8765-743X","authenticated-orcid":false,"given":"Jasper","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0488-4248","authenticated-orcid":false,"given":"Nikita","family":"Hanning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0327-6304","authenticated-orcid":false,"given":"Benedicte Y.","family":"De Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2506-6252","authenticated-orcid":false,"given":"Jean-Pierre","family":"Timmermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0960-6781","authenticated-orcid":false,"given":"Winnok H.","family":"De Vos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,10]]},"reference":[{"key":"10385_CR1","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1016\/j.celrep.2016.07.054","volume":"16","author":"K Aden","year":"2016","unstructured":"Aden K, Rehman A, Falk-Paulsen M et al (2016) Epithelial IL-23R signaling licenses protective IL-22 responses in intestinal inflammation. Cell Rep 16:2208\u20132218. https:\/\/doi.org\/10.1016\/j.celrep.2016.07.054","journal-title":"Cell Rep"},{"key":"10385_CR2","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1016\/J.PSYNEUEN.2012.03.024","volume":"37","author":"A Ait-Belgnaoui","year":"2012","unstructured":"Ait-Belgnaoui A, Durand H, Cartier C et al (2012) Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats. Psychoneuroendocrinology 37:1885\u20131895. https:\/\/doi.org\/10.1016\/J.PSYNEUEN.2012.03.024","journal-title":"Psychoneuroendocrinology"},{"key":"10385_CR3","doi-asserted-by":"publisher","first-page":"552","DOI":"10.4049\/JIMMUNOL.166.1.552","volume":"166","author":"MN Ajuebor","year":"2001","unstructured":"Ajuebor MN, Hogaboam CM, Kunkel SL et al (2001) The chemokine RANTES is a crucial mediator of the progression from acute to chronic colitis in the rat. J Immunol 166:552\u2013558. https:\/\/doi.org\/10.4049\/JIMMUNOL.166.1.552","journal-title":"J Immunol"},{"key":"10385_CR4","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1111\/J.1365-2249.2008.03658.X","volume":"152","author":"T Aprahamian","year":"2008","unstructured":"Aprahamian T, Takemura Y, Goukassian D, Walsh K (2008) Ageing is associated with diminished apoptotic cell clearance in vivo. Clin Exp Immunol 152:448\u2013455. https:\/\/doi.org\/10.1111\/J.1365-2249.2008.03658.X","journal-title":"Clin Exp Immunol"},{"key":"10385_CR5","doi-asserted-by":"publisher","DOI":"10.4049\/JIMMUNOL.1401313","volume":"193","author":"HH Arnardottir","year":"2014","unstructured":"Arnardottir HH, Dalli J, Colas RA et al (2014) Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nanoproresolving medicines. J Immunol 193:4235. https:\/\/doi.org\/10.4049\/JIMMUNOL.1401313","journal-title":"J Immunol"},{"key":"10385_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/J.YEXMP.2024.104923","volume":"139","author":"N Baidoo","year":"2024","unstructured":"Baidoo N, Sanger GJ (2024) Age-related decline in goblet cell numbers and mucin content of the human colon: implications for lower bowel functions in the elderly. Exp Mol Pathol 139:104923. https:\/\/doi.org\/10.1016\/J.YEXMP.2024.104923","journal-title":"Exp Mol Pathol"},{"key":"10385_CR7","doi-asserted-by":"publisher","DOI":"10.1093\/ECCO-JCC\/JJAA065","volume":"14","author":"D Bajic","year":"2020","unstructured":"Bajic D, Niemann A, Hillmer AK et al (2020) Gut microbiota-derived propionate regulates the expression of Reg3 mucosal lectins and ameliorates experimental colitis in mice. J Crohns Colitis 14:1462. https:\/\/doi.org\/10.1093\/ECCO-JCC\/JJAA065","journal-title":"J Crohns Colitis"},{"key":"10385_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-17204-5","volume":"7","author":"P Bankhead","year":"2017","unstructured":"Bankhead P, Loughrey MB, Fern\u00e1ndez JA et al (2017) QuPath: open source software for digital pathology image analysis. Sci Rep 7:1\u20137. https:\/\/doi.org\/10.1038\/s41598-017-17204-5","journal-title":"Sci Rep"},{"key":"10385_CR9","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1136\/GUTJNL-2016-312940","volume":"67","author":"L Becker","year":"2018","unstructured":"Becker L, Nguyen L, Gill J et al (2018) Age-dependent shift in macrophage polarisation causes inflammation-mediated degeneration of enteric nervous system. Gut 67:827\u2013836. https:\/\/doi.org\/10.1136\/GUTJNL-2016-312940","journal-title":"Gut"},{"key":"10385_CR10","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1093\/ecco-jcc\/jjaa015","volume":"2020","author":"T Breugelmans","year":"2020","unstructured":"Breugelmans T, Van SH, De Man JG et al (2020) In-depth study of transmembrane mucins in association with intestinal barrier dysfunction during the course of T cell transfer and DSS-induced colitis. J Crohns Colitis 2020:974\u2013994. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjaa015","journal-title":"J Crohns Colitis"},{"key":"10385_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/S12276-018-0126-X","volume":"50","author":"C Chelakkot","year":"2018","unstructured":"Chelakkot C, Ghim J, Ryu SH (2018) Mechanisms regulating intestinal barrier integrity and its pathological implications. Exp Mol Med 50:103. https:\/\/doi.org\/10.1038\/S12276-018-0126-X","journal-title":"Exp Mol Med"},{"key":"10385_CR12","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1093\/IBD\/IZAD283","volume":"30","author":"M Chen","year":"2024","unstructured":"Chen M, Wei S, Wu X et al (2024) 2\u02b9-hydroxycinnamaldehyde alleviates intestinal inflammation by attenuating intestinal mucosal barrier damage via directly inhibiting STAT3. Inflamm Bowel Dis 30:992\u20131008. https:\/\/doi.org\/10.1093\/IBD\/IZAD283","journal-title":"Inflamm Bowel Dis"},{"key":"10385_CR13","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/S12276-024-01179-1","volume":"56","author":"J Choi","year":"2024","unstructured":"Choi J, Augenlicht LH (2024) Intestinal stem cells: guardians of homeostasis in health and aging amid environmental challenges. Exp Mol Med 56:495. https:\/\/doi.org\/10.1038\/S12276-024-01179-1","journal-title":"Exp Mol Med"},{"key":"10385_CR14","doi-asserted-by":"publisher","DOI":"10.1111\/ACEL.14401","author":"J Conway","year":"2024","unstructured":"Conway J, De Jong EN, White AJ et al (2024) Age-related loss of intestinal barrier integrity plays an integral role in thymic involution and T cell ageing. Aging Cell. https:\/\/doi.org\/10.1111\/ACEL.14401","journal-title":"Aging Cell"},{"key":"10385_CR15","doi-asserted-by":"publisher","first-page":"16999","DOI":"10.1073\/PNAS.1311657110","volume":"110","author":"D Corridoni","year":"2013","unstructured":"Corridoni D, Kodani T, Rodriguez-Palacios A et al (2013) Dysregulated NOD2 predisposes SAMP1\/YitFc mice to chronic intestinal inflammation. Proc Natl Acad Sci USA 110:16999\u201317004. https:\/\/doi.org\/10.1073\/PNAS.1311657110","journal-title":"Proc Natl Acad Sci USA"},{"key":"10385_CR16","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1093\/ECCO-JCC\/JJAA214","volume":"15","author":"F Deng","year":"2021","unstructured":"Deng F, Yan J, Lu J et al (2021) M2 macrophage-derived exosomal miR-590-3p attenuates DSS-induced mucosal damage and promotes epithelial repair via the LATS1\/YAP\/ \u03b2-catenin signalling axis. J Crohns Colitis 15:665\u2013677. https:\/\/doi.org\/10.1093\/ECCO-JCC\/JJAA214","journal-title":"J Crohns Colitis"},{"key":"10385_CR17","doi-asserted-by":"publisher","first-page":"5471","DOI":"10.2147\/JIR.S377077","volume":"15","author":"F Deng","year":"2022","unstructured":"Deng F, Wu Z, Xu M, Xia P (2022) YAP activates STAT3 signalling to promote colonic epithelial cell proliferation in DSS-induced colitis and colitis associated cancer. J Inflamm Res 15:5471\u20135482. https:\/\/doi.org\/10.2147\/JIR.S377077","journal-title":"J Inflamm Res"},{"key":"10385_CR18","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0042568","volume":"7","author":"S Ding","year":"2012","unstructured":"Ding S, Walton KLW, Blue RE et al (2012) Mucosal healing and fibrosis after acute or chronic inflammation in wild type FVB-N mice and C57BL6 procollagen \u03b11(I)-promoter-GFP reporter mice. PLoS ONE 7:e42568. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0042568","journal-title":"PLoS ONE"},{"key":"10385_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2022.943159","volume":"13","author":"CT Dube","year":"2022","unstructured":"Dube CT, Ong YHB, Wemyss K et al (2022) Age-related alterations in macrophage distribution and function are associated with delayed cutaneous wound healing. Front Immunol 13:943159. https:\/\/doi.org\/10.3389\/FIMMU.2022.943159","journal-title":"Front Immunol"},{"key":"10385_CR20","first-page":"4557","volume":"7","author":"U Erben","year":"2014","unstructured":"Erben U, Loddenkemper C, Doerfel K et al (2014) A guide to histomorphological evaluation of intestinal inflammation in mouse models. Int J Clin Exp Pathol 7:4557","journal-title":"Int J Clin Exp Pathol"},{"key":"10385_CR21","doi-asserted-by":"publisher","first-page":"792746","DOI":"10.3389\/FIMMU.2021.792746\/BIBTEX","volume":"12","author":"X Fang","year":"2021","unstructured":"Fang X, Yue M, Wei J et al (2021) Evaluation of the anti-aging effects of a probiotic combination isolated from centenarians in a SAMP8 mouse model. Front Immunol 12:792746. https:\/\/doi.org\/10.3389\/FIMMU.2021.792746\/BIBTEX","journal-title":"Front Immunol"},{"key":"10385_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0149-7634(96)00063-2","volume":"22","author":"JF Flood","year":"1997","unstructured":"Flood JF, E. Morley J (1997) Learning and memory in the SAMP8 mouse. Neurosci Biobehav Rev 22:1\u201320. https:\/\/doi.org\/10.1016\/S0149-7634(96)00063-2","journal-title":"Neurosci Biobehav Rev"},{"key":"10385_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-31492-5","volume":"8","author":"JP Ganda Mall","year":"2018","unstructured":"Ganda Mall JP, L\u00f6fvendahl L, Lindqvist CM et al (2018) Differential effects of dietary fibres on colonic barrier function in elderly individuals with gastrointestinal symptoms. Sci Rep 8:1\u201311. https:\/\/doi.org\/10.1038\/s41598-018-31492-5","journal-title":"Sci Rep"},{"key":"10385_CR24","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/PATH.5134","volume":"246","author":"L Genser","year":"2018","unstructured":"Genser L, Aguanno D, Soula HA et al (2018) Increased jejunal permeability in human obesity is revealed by a lipid challenge and is linked to inflammation and type 2 diabetes. J Pathol 246:217\u2013230. https:\/\/doi.org\/10.1002\/PATH.5134","journal-title":"J Pathol"},{"key":"10385_CR25","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/J.AJPATH.2024.10.020","volume":"195","author":"R Gomez-Bris","year":"2024","unstructured":"Gomez-Bris R, Rodr\u00edguez-Rodr\u00edguez P, Ortega-Zapero M et al (2024) Segmental regulation of intestinal motility by colitis and the adaptive immune system in the mouse ileum and colon. Am J Pathol 195:204\u2013220. https:\/\/doi.org\/10.1016\/J.AJPATH.2024.10.020","journal-title":"Am J Pathol"},{"key":"10385_CR26","doi-asserted-by":"publisher","DOI":"10.1177\/1756284821993586","volume":"14","author":"N Hanning","year":"2021","unstructured":"Hanning N, Edwinson AL, Ceuleers H et al (2021) Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review. Therap Adv Gastroenterol 14:1756284821993586. https:\/\/doi.org\/10.1177\/1756284821993586","journal-title":"Therap Adv Gastroenterol"},{"key":"10385_CR27","doi-asserted-by":"publisher","DOI":"10.21769\/BIOPROTOC.4758","volume":"13","author":"N Hanning","year":"2023","unstructured":"Hanning N, De Man JG, De Winter BY (2023) Measuring myeloperoxidase activity as a marker of inflammation in gut tissue samples of mice and rat. Bio Protoc 13:e4758. https:\/\/doi.org\/10.21769\/BIOPROTOC.4758","journal-title":"Bio Protoc"},{"key":"10385_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/S41522-025-00677-Y","volume":"11","author":"Y Jing","year":"2025","unstructured":"Jing Y, Wang Q, Bai F et al (2025) Age-related alterations in gut homeostasis are microbiota dependent. NPJ Biofilms Microbiomes 11:51. https:\/\/doi.org\/10.1038\/S41522-025-00677-Y","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10385_CR29","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1113\/JP271493","volume":"594","author":"D Krueger","year":"2016","unstructured":"Krueger D, Michel K, Zeller F et al (2016) Neural influences on human intestinal epithelium in vitro. J Physiol 594:357\u2013372. https:\/\/doi.org\/10.1113\/JP271493","journal-title":"J Physiol"},{"key":"10385_CR30","doi-asserted-by":"publisher","DOI":"10.4110\/IN.2018.18.E30","volume":"18","author":"SH Kwon","year":"2018","unstructured":"Kwon SH, Seo EB, Lee SH et al (2018) T cell-specific knockout of STAT3 ameliorates dextran sulfate sodium-induced colitis by reducing the inflammatory response. Immune Netw 18:e30. https:\/\/doi.org\/10.4110\/IN.2018.18.E30","journal-title":"Immune Netw"},{"key":"10385_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41392-023-01502-8","volume":"8","author":"X Li","year":"2023","unstructured":"Li X, Li C, Zhang W et al (2023) Inflammation and aging: signaling pathways and intervention therapies. Signal Transduction Target Therap 8:1\u201329. https:\/\/doi.org\/10.1038\/s41392-023-01502-8","journal-title":"Signal Transduction Target Therap"},{"key":"10385_CR32","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1093\/GERONA\/GLZ263","volume":"75","author":"A Liu","year":"2020","unstructured":"Liu A, Lv H, Wang H et al (2020) Aging increases the severity of colitis and the related changes to the gut barrier and gut microbiota in humans and mice. J Gerontol A Biol Sci Med Sci 75:1284\u20131292. https:\/\/doi.org\/10.1093\/GERONA\/GLZ263","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10385_CR33","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/J.CELL.2022.11.001","volume":"186","author":"C L\u00f3pez-Ot\u00edn","year":"2023","unstructured":"L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L et al (2023) Hallmarks of aging: an expanding universe. Cell 186:243\u2013278. https:\/\/doi.org\/10.1016\/J.CELL.2022.11.001","journal-title":"Cell"},{"key":"10385_CR34","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1042\/CS20150046","volume":"129","author":"AL Man","year":"2015","unstructured":"Man AL, Bertelli E, Rentini S et al (2015) Age-associated modifications of intestinal permeability and innate immunity in human small intestine. Clin Sci 129:515\u2013527. https:\/\/doi.org\/10.1042\/CS20150046","journal-title":"Clin Sci"},{"key":"10385_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep30802","volume":"6","author":"A Mencarelli","year":"2016","unstructured":"Mencarelli A, Cipriani S, Francisci D et al (2016) Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis. Sci Rep 6:1\u201312. https:\/\/doi.org\/10.1038\/srep30802","journal-title":"Sci Rep"},{"key":"10385_CR36","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0174121","volume":"12","author":"P Menghini","year":"2017","unstructured":"Menghini P, Di Martino L, Lopetuso LR et al (2017) A novel model of colitis-associated cancer in SAMP1\/YitFc mice with Crohn\u2019s disease-like ileitis. PLoS ONE 12:e0174121. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0174121","journal-title":"PLoS ONE"},{"key":"10385_CR37","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/0031-9384(86)90112-5","volume":"38","author":"M Miyamoto","year":"1986","unstructured":"Miyamoto M, Kiyota Y, Yamazaki N et al (1986) Age-related changes in learning and memory in the senescence-accelerated mouse (SAM). Physiol Behav 38:399\u2013406. https:\/\/doi.org\/10.1016\/0031-9384(86)90112-5","journal-title":"Physiol Behav"},{"key":"10385_CR38","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.18632\/AGING.101279","volume":"9","author":"EC Moorefield","year":"2017","unstructured":"Moorefield EC, Andres SF, Blue RE et al (2017) Aging effects on intestinal homeostasis associated with expansion and dysfunction of intestinal epithelial stem cells. Aging 9:1898\u20131915. https:\/\/doi.org\/10.18632\/AGING.101279","journal-title":"Aging"},{"key":"10385_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/J.CELREP.2024.114073","author":"CE Moss","year":"2024","unstructured":"Moss CE, Johnston SA, Kimble JV et al (2024) Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs. Cell Rep. https:\/\/doi.org\/10.1016\/J.CELREP.2024.114073","journal-title":"Cell Rep"},{"key":"10385_CR40","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1152\/AJPGI.00315.2006","volume":"292","author":"T Ohama","year":"2007","unstructured":"Ohama T, Hori M, Momotani E et al (2007) Intestinal inflammation downregulates smooth muscle CPI-17 through induction of TNF-\u03b1 and causes motility disorders. Am J Physiol Gastrointest Liver Physiol 292:1429\u20131438. https:\/\/doi.org\/10.1152\/AJPGI.00315.2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10385_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/BIOMEDICINES9020187","volume":"9","author":"L Pang","year":"2021","unstructured":"Pang L, Huynh J, Alorro MG et al (2021) STAT3 signalling via the IL-6ST\/gp130 cytokine receptor promotes epithelial integrity and intestinal barrier function during DSS-induced colitis. Biomedicines 9:187. https:\/\/doi.org\/10.3390\/BIOMEDICINES9020187","journal-title":"Biomedicines"},{"key":"10385_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28497-0","author":"SM Parigi","year":"2022","unstructured":"Parigi SM, Larsson L, Das S et al (2022) The spatial transcriptomic landscape of the healing mouse intestine following damage. Nat Commun. https:\/\/doi.org\/10.1038\/s41467-022-28497-0","journal-title":"Nat Commun"},{"key":"10385_CR43","doi-asserted-by":"publisher","first-page":"3523","DOI":"10.3390\/IJMS21103523","volume":"21","author":"C Pellegrini","year":"2020","unstructured":"Pellegrini C, Daniele S, Antonioli L et al (2020) Prodromal intestinal events in Alzheimer\u2019s disease (AD): colonic dysmotility and inflammation are associated with enteric AD-related protein deposition. Int J Mol Sci 21:3523. https:\/\/doi.org\/10.3390\/IJMS21103523","journal-title":"Int J Mol Sci"},{"key":"10385_CR44","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1084\/JEM.20082683","volume":"206","author":"G Pickert","year":"2009","unstructured":"Pickert G, Neufert C, Leppkes M et al (2009) STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med 206:1465\u20131472. https:\/\/doi.org\/10.1084\/JEM.20082683","journal-title":"J Exp Med"},{"key":"10385_CR45","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/J.IJMM.2016.03.004","volume":"306","author":"P Rausch","year":"2016","unstructured":"Rausch P, Basic M, Batra A et al (2016) Analysis of factors contributing to variation in the C57BL\/6J fecal microbiota across German animal facilities. Int J Med Microbiol 306:343\u2013355. https:\/\/doi.org\/10.1016\/J.IJMM.2016.03.004","journal-title":"Int J Med Microbiol"},{"key":"10385_CR46","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2001455","author":"J Ren","year":"2021","unstructured":"Ren J, Han X, Lohner H (2021) Title serum-and glucocorticoid-inducible kinase 1 promotes alternative macrophage polarization and restrains inflammation through FoxO1 and STAT3 signaling. J Immunol. https:\/\/doi.org\/10.4049\/jimmunol.2001455","journal-title":"J Immunol"},{"key":"10385_CR47","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.3390\/CANCERS15112977","volume":"15","author":"P Robinson","year":"2023","unstructured":"Robinson P, Montoya K, Magness E et al (2023) Therapeutic potential of a small-molecule STAT3 inhibitor in a mouse model of colitis. Cancers (Basel) 15:2977. https:\/\/doi.org\/10.3390\/CANCERS15112977","journal-title":"Cancers (Basel)"},{"key":"10385_CR48","first-page":"291","volume":"23","author":"AC Ruifrok","year":"2001","unstructured":"Ruifrok AC, Johnston DA (2001) Quantification of histochemical staining by color deconvolution. Anal Quant Cytol Histol 23:291\u2013299","journal-title":"Anal Quant Cytol Histol"},{"key":"10385_CR49","doi-asserted-by":"publisher","DOI":"10.3390\/NU15081830","author":"X Sang","year":"2023","unstructured":"Sang X, Wang Q, Ning Y et al (2023) Age-related mucus barrier dysfunction in mice is related to the changes in Muc2 mucin in the colon. Nutrients. https:\/\/doi.org\/10.3390\/NU15081830","journal-title":"Nutrients"},{"key":"10385_CR50","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/NMETH.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin J, Arganda-Carreras I, Frise E et al (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods 9:676\u2013682. https:\/\/doi.org\/10.1038\/NMETH.2019","journal-title":"Nat Methods"},{"key":"10385_CR51","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1016\/J.CMET.2022.09.024","volume":"34","author":"JH Shin","year":"2022","unstructured":"Shin JH, Bozadjieva-Kramer N, Shao Y et al (2022) The gut peptide Reg3g links the small intestine microbiome to the regulation of energy balance, glucose levels, and gut function. Cell Metab 34:1765-1778.e6. https:\/\/doi.org\/10.1016\/J.CMET.2022.09.024","journal-title":"Cell Metab"},{"key":"10385_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBREP.2020.100738","volume":"21","author":"R Shindo","year":"2020","unstructured":"Shindo R, Katagiri T, Komazawa-Sakon S et al (2020) Regenerating islet-derived protein (Reg)3\u03b2 plays a crucial role in attenuation of ileitis and colitis in mice. Biochem Biophys Rep 21:100738. https:\/\/doi.org\/10.1016\/J.BBREP.2020.100738","journal-title":"Biochem Biophys Rep"},{"key":"10385_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S40168-025-02089-8","volume":"13","author":"F Sommer","year":"2025","unstructured":"Sommer F, Bernardes JP, Best L et al (2025) Life-long microbiome rejuvenation improves intestinal barrier function and inflammaging in mice. Microbiome 13:1\u201320. https:\/\/doi.org\/10.1186\/S40168-025-02089-8","journal-title":"Microbiome"},{"issue":"1","key":"10385_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35228-3","volume":"9","author":"B Sovran","year":"2019","unstructured":"Sovran B, Hugenholtz F, Elderman M et al (2019) Age-associated impairment of the mucus barrier function is associated with profound changes in microbiota and immunity. Sci Rep 9(1):1437. https:\/\/doi.org\/10.1038\/s41598-018-35228-3","journal-title":"Sci Rep"},{"key":"10385_CR55","doi-asserted-by":"publisher","first-page":"3801","DOI":"10.1073\/PNAS.94.8.3801","volume":"94","author":"K Takeda","year":"1997","unstructured":"Takeda K, Noguchi K, Shi W et al (1997a) Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci USA 94:3801\u20133804. https:\/\/doi.org\/10.1073\/PNAS.94.8.3801","journal-title":"Proc Natl Acad Sci USA"},{"key":"10385_CR56","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0531-5565(96)00036-8","volume":"32","author":"T Takeda","year":"1997","unstructured":"Takeda T, Hosokawa M, Higuchi K (1997b) Senescence-accelerated mouse (SAM): a novel murine model of senescence. Exp Gerontol 32:105\u2013109. https:\/\/doi.org\/10.1016\/S0531-5565(96)00036-8","journal-title":"Exp Gerontol"},{"key":"10385_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2164-14-248","volume":"14","author":"K Tanisawa","year":"2013","unstructured":"Tanisawa K, Mikami E, Fuku N et al (2013) Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes. BMC Genomics 14:1\u201315. https:\/\/doi.org\/10.1186\/1471-2164-14-248","journal-title":"BMC Genomics"},{"key":"10385_CR58","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/J.CHOM.2017.03.002","volume":"21","author":"N Thevaranjan","year":"2017","unstructured":"Thevaranjan N, Puchta A, Schulz C et al (2017) Age-associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction. Cell Host Microbe 21:455. https:\/\/doi.org\/10.1016\/J.CHOM.2017.03.002","journal-title":"Cell Host Microbe"},{"key":"10385_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12876-019-1002-4","volume":"19","author":"A Thomson","year":"2019","unstructured":"Thomson A, Smart K, Somerville MS et al (2019) The Ussing chamber system for measuring intestinal permeability in health and disease. BMC Gastroenterol 19:1\u201314. https:\/\/doi.org\/10.1186\/S12876-019-1002-4","journal-title":"BMC Gastroenterol"},{"key":"10385_CR60","doi-asserted-by":"publisher","DOI":"10.1002\/MNFR.202000745","volume":"65","author":"B Tian","year":"2021","unstructured":"Tian B, Zhao J, Zhang M et al (2021) Lycium ruthenicum anthocyanins attenuate high-fat diet-induced colonic barrier dysfunction and inflammation in mice by modulating the gut microbiota. Mol Nutr Food Res 65:2000745. https:\/\/doi.org\/10.1002\/MNFR.202000745","journal-title":"Mol Nutr Food Res"},{"key":"10385_CR61","doi-asserted-by":"publisher","first-page":"3767","DOI":"10.1007\/S00394-022-02927-7","volume":"61","author":"B Tian","year":"2022","unstructured":"Tian B, Geng Y, Wang P et al (2022) Ferulic acid improves intestinal barrier function through altering gut microbiota composition in high-fat diet-induced mice. Eur J Nutr 61:3767\u20133783. https:\/\/doi.org\/10.1007\/S00394-022-02927-7","journal-title":"Eur J Nutr"},{"key":"10385_CR62","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1093\/GERONA\/GLT106","volume":"68","author":"L Tran","year":"2013","unstructured":"Tran L, Greenwood-Van Meerveld B (2013) Age-associated remodeling of the intestinal epithelial barrier. J Gerontol A Biol Sci Med Sci 68:1045. https:\/\/doi.org\/10.1093\/GERONA\/GLT106","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10385_CR63","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1136\/GUTJNL-2013-305690","volume":"63","author":"T Vanuytsel","year":"2014","unstructured":"Vanuytsel T, Van Wanrooy S, Vanheel H et al (2014) Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism. Gut 63:1293\u20131299. https:\/\/doi.org\/10.1136\/GUTJNL-2013-305690","journal-title":"Gut"},{"key":"10385_CR64","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1097\/MIB.0B013E31828028AD","volume":"19","author":"TA Willson","year":"2013","unstructured":"Willson TA, Jurickova I, Collins M, Denson LA (2013) Deletion of intestinal epithelial cell STAT3 promotes T lymphocyte STAT3 activation and chronic colitis following acute dextran sodium sulfate injury in mice. Inflamm Bowel Dis 19:512. https:\/\/doi.org\/10.1097\/MIB.0B013E31828028AD","journal-title":"Inflamm Bowel Dis"},{"key":"10385_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-57106-2","volume":"10","author":"E Wilms","year":"2020","unstructured":"Wilms E, Troost FJ, Elizalde M et al (2020) Intestinal barrier function is maintained with aging\u2014a comprehensive study in healthy subjects and irritable bowel syndrome patients. Sci Rep 10:1\u201310. https:\/\/doi.org\/10.1038\/s41598-019-57106-2","journal-title":"Sci Rep"},{"key":"10385_CR66","doi-asserted-by":"publisher","first-page":"1160719","DOI":"10.3389\/FIMMU.2023.1160719\/XML\/NLM","volume":"14","author":"T Xia","year":"2023","unstructured":"Xia T, Zhang M, Lei W et al (2023) Advances in the role of STAT3 in macrophage polarization. Front Immunol 14:1160719. https:\/\/doi.org\/10.3389\/FIMMU.2023.1160719\/XML\/NLM","journal-title":"Front Immunol"},{"key":"10385_CR67","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/J.JCMGH.2019.02.006","volume":"8","author":"Y Xiao","year":"2019","unstructured":"Xiao Y, Huang X, Zhao Y et al (2019) Interleukin-33 promotes REG3\u03b3 expression in intestinal epithelial cells and regulates gut microbiota. Cell Mol Gastroenterol Hepatol 8:21\u201336. https:\/\/doi.org\/10.1016\/J.JCMGH.2019.02.006","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10385_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/J.JEP.2025.119944","author":"S Zhang","year":"2025","unstructured":"Zhang S, Mao X, Chang L et al (2025) Bazi bushen capsule modulates Akkermansia muciniphila and spermidine metabolism to attenuate brain aging in SAMP8 mice. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/J.JEP.2025.119944","journal-title":"J Ethnopharmacol"}],"container-title":["Biogerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-026-10385-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10522-026-10385-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-026-10385-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:39:09Z","timestamp":1771396749000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10522-026-10385-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,10]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10385"],"URL":"https:\/\/doi.org\/10.1007\/s10522-026-10385-5","relation":{},"ISSN":["1389-5729","1573-6768"],"issn-type":[{"value":"1389-5729","type":"print"},{"value":"1573-6768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,10]]},"assertion":[{"value":"16 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All mice were treated in accordance with the guidelines approved by the European Ethics Committee (decree 86\/609\/CEE) and the Animal Welfare Act (7 USC 2131). All animal experiments were approved by the ethical committee of the University of Antwerp (ECD 2020\u201336).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"36"}}