{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T10:54:50Z","timestamp":1780656890138,"version":"3.54.1"},"reference-count":118,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biogerontology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s10522-026-10401-8","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T11:58:39Z","timestamp":1770379119000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Critical roles of m6A demethylase FTO in ovarian aging"],"prefix":"10.1007","volume":"27","author":[{"given":"Saba","family":"Hadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Hossein","family":"Khoshraftar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Hossein Kiani","family":"Darabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid Reza","family":"Nejabati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"10401_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/genes12060946","author":"MC Azcona-Sanjulian","year":"2021","unstructured":"Azcona-Sanjulian MC (2021) Telomere length and pediatric obesity: a review. Genes. https:\/\/doi.org\/10.3390\/genes12060946","journal-title":"Genes"},{"key":"10401_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073800","author":"SK Azzam","year":"2022","unstructured":"Azzam SK, Alsafar H, Sajini AA (2022) FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23073800","journal-title":"Int J Mol Sci"},{"key":"10401_CR5","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.stem.2014.09.019","volume":"15","author":"PJ Batista","year":"2014","unstructured":"Batista PJ, Molinie B, Wang J, Qu K, Zhang J, Li L, Bouley DM, Lujan E, Haddad B, Daneshvar K, Carter AC, Flynn RA, Zhou C, Lim KS, Dedon P, Wernig M, Mullen AC, Xing Y, Giallourakis CC, Chang HY (2014) m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell 15:707\u2013719","journal-title":"Cell Stem Cell"},{"key":"10401_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2024.1500394","volume":"12","author":"D Benak","year":"2024","unstructured":"Benak D, Sevcikova A, Holzerova K, Hlavackova M (2024) FTO in health and disease. Front Cell Dev Biol 12:1500394","journal-title":"Front Cell Dev Biol"},{"key":"10401_CR7","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1038\/nsmb0908-998b","volume":"15","author":"R Benetti","year":"2008","unstructured":"Benetti R, Gonzalo S, Jaco I, Mu\u00f1oz P, Gonzalez S, Schoeftner S, Murchison E, Andl T, Chen T, Klatt P, Li E, Serrano M, Millar S, Hannon G, Blasco MA (2008) A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol 15:998","journal-title":"Nat Struct Mol Biol"},{"key":"10401_CR8","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.ajhg.2009.06.002","volume":"85","author":"S Boissel","year":"2009","unstructured":"Boissel S, Reish O, Proulx K, Kawagoe-Takaki H, Sedgwick B, Yeo GS, Meyre D, Golzio C, Molinari F, Kadhom N (2009) Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Am J Hum Genet 85:106\u2013111","journal-title":"Am J Hum Genet"},{"key":"10401_CR9","doi-asserted-by":"publisher","first-page":"3392","DOI":"10.1093\/eurheartj\/ehv587","volume":"36","author":"GG Camici","year":"2015","unstructured":"Camici GG, Savarese G, Akhmedov A, L\u00fcscher TF (2015) Molecular mechanism of endothelial and vascular aging: implications for cardiovascular disease. Eur Heart J 36:3392\u20133403","journal-title":"Eur Heart J"},{"key":"10401_CR10","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2677312","volume":"2022","author":"R Chang","year":"2022","unstructured":"Chang R, Huang Z, Zhao S, Zou J, Li Y, Tan S (2022) Emerging roles of FTO in neuropsychiatric disorders. Biomed Res Int 2022:2677312","journal-title":"Biomed Res Int"},{"key":"10401_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134600","volume":"278","author":"L Chen","year":"2024","unstructured":"Chen L, Liu J, Rao Z (2024) FTO-overexpressing extracellular vesicles from BM-MSCs reverse cellular senescence and aging to ameliorate osteoarthritis by modulating METTL3\/YTHDF2-mediated RNA m6A modifications. Int J Biol Macromol 278:134600","journal-title":"Int J Biol Macromol"},{"key":"10401_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101168","volume":"63","author":"JL Chiang","year":"2020","unstructured":"Chiang JL, Shukla P, Pagidas K, Ahmed NS, Karri S, Gunn DD, Hurd WW, Singh KK (2020) Mitochondria in ovarian aging and reproductive longevity. Ageing Res Rev 63:101168","journal-title":"Ageing Res Rev"},{"key":"10401_CR13","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/s10815-018-1143-3","volume":"35","author":"MG Da Broi","year":"2018","unstructured":"Da Broi MG, Giorgi VSI, Wang F, Keefe DL, Albertini D, Navarro PA (2018) Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications. J Assist Reprod Genet 35:735\u2013751","journal-title":"J Assist Reprod Genet"},{"key":"10401_CR14","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1093\/humrep\/deu160","volume":"29","author":"G Di Emidio","year":"2014","unstructured":"Di Emidio G, Falone S, Vitti M, D\u2019alessandro AM, Vento M, Di Pietro C, Amicarelli F, Tatone C (2014) SIRT1 signalling protects mouse oocytes against oxidative stress and is deregulated during aging. Hum Reprod 29:2006\u20132017","journal-title":"Hum Reprod"},{"key":"10401_CR15","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.cca.2012.03.025","volume":"413","author":"D Dlouha","year":"2012","unstructured":"Dlouha D, Pitha J, Lanska V, Hubacek JA (2012) Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study. Clin Chim Acta 413:1222\u20131225","journal-title":"Clin Chim Acta"},{"key":"10401_CR16","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.5114\/aoms.2019.87239","volume":"15","author":"S Doaei","year":"2019","unstructured":"Doaei S, Kalantari N, Mohammadi NK, Izadi P, Gholamalizadeh M, Eini-Zinab H, Salonurmi T, Jarrahi A, Rafieifar S, Janipoor R (2019) Up-regulation of FTO gene expression was associated with increase in skeletal muscle mass in overweight male adolescents. Arch Med Sci 15:1133\u20131137","journal-title":"Arch Med Sci"},{"key":"10401_CR17","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nature11112","volume":"485","author":"D Dominissini","year":"2012","unstructured":"Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, Cesarkas K, Jacob-Hirsch J, Amariglio N, Kupiec M (2012) Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485:201\u2013206","journal-title":"Nature"},{"key":"10401_CR18","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1093\/oxfordjournals.humrep.a137570","volume":"7","author":"MJ Faddy","year":"1992","unstructured":"Faddy MJ, Gosden RG, Gougeon A, Richardson SJ, Nelson JF (1992) Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause. Hum Reprod 7:1342\u20131346","journal-title":"Hum Reprod"},{"key":"10401_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127705","volume":"10","author":"H-Q Fan","year":"2015","unstructured":"Fan H-Q, He W, Xu K-F, Wang Z-X, Xu X-Y, Chen H (2015) FTO inhibits insulin secretion and promotes NF-\u03baB activation through positively regulating ROS production in pancreatic \u03b2 cells. PLoS ONE 10:e0127705","journal-title":"PLoS ONE"},{"key":"10401_CR20","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1126\/science.1141634","volume":"316","author":"TM Frayling","year":"2007","unstructured":"Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889\u2013894","journal-title":"Science"},{"key":"10401_CR21","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1016\/j.bbamcr.2017.05.007","volume":"1864","author":"S Freitas-Rodr\u00edguez","year":"2017","unstructured":"Freitas-Rodr\u00edguez S, Folgueras AR, L\u00f3pez-Ot\u00edn C (2017) The role of matrix metalloproteinases in aging: tissue remodeling and beyond. Biochim Biophys Acta Mol Cell Res 1864:2015\u20132025","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10401_CR22","doi-asserted-by":"publisher","first-page":"R103","DOI":"10.1530\/REP-14-0242","volume":"149","author":"ZJ Ge","year":"2015","unstructured":"Ge ZJ, Schatten H, Zhang CL, Sun QY (2015) Oocyte ageing and epigenetics. Reproduction 149:R103\u2013R114","journal-title":"Reproduction"},{"key":"10401_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-024-03262-1","volume":"24","author":"A Gupta","year":"2024","unstructured":"Gupta A, Lu E, Thayer Z (2024) The influence of assisted reproductive technologies-related stressors and social support on perceived stress and depression. BMC Womens Health 24:431","journal-title":"BMC Womens Health"},{"key":"10401_CR24","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1038\/nature08921","volume":"464","author":"Z Han","year":"2010","unstructured":"Han Z, Niu T, Chang J, Lei X, Zhao M, Wang Q, Cheng W, Wang J, Feng Y, Chai J (2010) Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature 464:1205\u20131209","journal-title":"Nature"},{"key":"10401_CR25","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1093\/humrep\/dem408","volume":"23","author":"KR Hansen","year":"2008","unstructured":"Hansen KR, Knowlton NS, Thyer AC, Charleston JS, Soules MR, Klein NA (2008) A new model of reproductive aging: the decline in ovarian non-growing follicle number from birth to menopause. Hum Reprod 23:699\u2013708","journal-title":"Hum Reprod"},{"key":"10401_CR26","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1080\/15548627.2022.2063005","volume":"19","author":"H He","year":"2023","unstructured":"He H, Wang J, Mou X, Liu X, Li Q, Zhong M, Luo B, Yu Z, Zhang J, Xu T, Dou C, Wu D, Qing W, Wu L, Zhou K, Fan Z, Wang T, Hu T, Zhang X, Zhou J, Miao YL (2023) Selective autophagic degradation of ACLY (ATP citrate lyase) maintains citrate homeostasis and promotes oocyte maturation. Autophagy 19:163\u2013179","journal-title":"Autophagy"},{"key":"10401_CR27","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1038\/nn.3449","volume":"16","author":"ME Hess","year":"2013","unstructured":"Hess ME, Hess S, Meyer KD, Verhagen LA, Koch L, Br\u00f6nneke HS, Dietrich MO, Jordan SD, Saletore Y, Elemento O (2013) The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci 16:1042\u20131048","journal-title":"Nat Neurosci"},{"key":"10401_CR28","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1177\/0004563217739930","volume":"55","author":"JW Honour","year":"2018","unstructured":"Honour JW (2018) Biochemistry of the menopause. Ann Clin Biochem 55:18\u201333","journal-title":"Ann Clin Biochem"},{"key":"10401_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11080689","volume":"11","author":"Y-T Hsiao","year":"2021","unstructured":"Hsiao Y-T, Shen F-C, Weng S-W, Wang P-W, Chen Y-J, Lee J-J (2021) Multiple single nucleotide polymorphism testing improves the prediction of diabetic retinopathy risk with type 2 diabetes mellitus. J Pers Med 11:689","journal-title":"J Pers Med"},{"key":"10401_CR30","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1159\/000526752","volume":"113","author":"F Hu","year":"2023","unstructured":"Hu F, Yan H-J, Gao C-X, Sun W-W, Long Y-S (2023) Inhibition of hypothalamic FTO activates STAT3 signal through ERK1\/2 associated with reductions in food intake and body weight. Neuroendocrinology 113:80\u201391","journal-title":"Neuroendocrinology"},{"key":"10401_CR31","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14376","volume":"24","author":"X Hu","year":"2025","unstructured":"Hu X, Lu J, Ding C, Li J, Zou Q, Xia W, Qian C, Li H, Huang B (2025) The N6-methyladenosine landscape of ovarian development and aging highlights the regulation by RNA stability and chromatin state. Aging Cell 24:e14376","journal-title":"Aging Cell"},{"key":"10401_CR32","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.molcel.2017.08.003","volume":"67","author":"I Ivanova","year":"2017","unstructured":"Ivanova I, Much C, Di Giacomo M, Azzi C, Morgan M, Moreira PN, Monahan J, Carrieri C, Enright AJ, O\u2019carroll D (2017) The RNA m(6)A reader YTHDF2 is essential for the post-transcriptional regulation of the maternal transcriptome and oocyte competence. Mol Cell 67:1059-1067.e4","journal-title":"Mol Cell"},{"key":"10401_CR33","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nchembio.687","volume":"7","author":"G Jia","year":"2011","unstructured":"Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang Y-G (2011a) N 6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol 7:885\u2013887","journal-title":"Nat Chem Biol"},{"key":"10401_CR34","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nchembio.687","volume":"7","author":"G Jia","year":"2011","unstructured":"Jia G, Fu Y, Zhao X, Dai Q, Zheng G, Yang Y, Yi C, Lindahl T, Pan T, Yang YG, He C (2011b) N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol 7:885\u2013887","journal-title":"Nat Chem Biol"},{"key":"10401_CR35","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.joca.2021.11.009","volume":"30","author":"Y Jiang","year":"2022","unstructured":"Jiang Y (2022) Osteoarthritis year in review 2021: biology. Osteoarthritis Cartilage 30:207\u2013215","journal-title":"Osteoarthritis Cartilage"},{"key":"10401_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04016-9","volume":"12","author":"ZX Jiang","year":"2021","unstructured":"Jiang ZX, Wang YN, Li ZY, Dai ZH, He Y, Chu K, Gu JY, Ji YX, Sun NX, Yang F, Li W (2021) The m6A mRNA demethylase FTO in granulosa cells retards FOS-dependent ovarian aging. Cell Death Dis 12:744","journal-title":"Cell Death Dis"},{"key":"10401_CR37","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s11427-012-4355-2","volume":"55","author":"M Jin","year":"2012","unstructured":"Jin M, Yu Y, Huang H (2012) An update on primary ovarian insufficiency. Sci China Life Sci 55:677\u2013686","journal-title":"Sci China Life Sci"},{"key":"10401_CR38","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1080\/15548627.2021.1946739","volume":"18","author":"X Jin","year":"2022","unstructured":"Jin X, Wang K, Wang L, Liu W, Zhang C, Qiu Y, Liu W, Zhang H, Zhang D, Yang Z, Wu T, Li J (2022) RAB7 activity is required for the regulation of mitophagy in oocyte meiosis and oocyte quality control during ovarian aging. Autophagy 18:643\u2013660","journal-title":"Autophagy"},{"key":"10401_CR39","doi-asserted-by":"publisher","first-page":"726","DOI":"10.2337\/db09-1277","volume":"59","author":"JB Jowett","year":"2010","unstructured":"Jowett JB, Curran JE, Johnson MP, Carless MA, G\u00f6ring HH, Dyer TD, Cole SA, Comuzzie AG, Maccluer JW, Moses EK, Blangero J (2010) Genetic variation at the FTO locus influences RBL2 gene expression. Diabetes 59:726\u2013732","journal-title":"Diabetes"},{"key":"10401_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1361289","volume":"15","author":"W Ju","year":"2024","unstructured":"Ju W, Zhao Y, Yu Y, Zhao S, Xiang S, Lian F (2024) Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions. Front Endocrinol (Lausanne) 15:1361289","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10401_CR41","doi-asserted-by":"publisher","first-page":"5676","DOI":"10.1002\/jcb.26746","volume":"119","author":"H Kang","year":"2018","unstructured":"Kang H, Zhang Z, Yu L, Li Y, Liang M, Zhou L (2018) FTO reduces mitochondria and promotes hepatic fat accumulation through RNA demethylation. J Cell Biochem 119:5676\u20135685","journal-title":"J Cell Biochem"},{"key":"10401_CR42","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/s41591-022-02194-3","volume":"29","author":"H Ke","year":"2023","unstructured":"Ke H, Tang S, Guo T, Hou D, Jiao X, Li S, Luo W, Xu B, Zhao S, Li G, Zhang X, Xu S, Wang L, Wu Y, Wang J, Zhang F, Qin Y, Jin L, Chen ZJ (2023) Landscape of pathogenic mutations in premature ovarian insufficiency. Nat Med 29:483\u2013492","journal-title":"Nat Med"},{"key":"10401_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.101907","volume":"298","author":"B Khatiwada","year":"2022","unstructured":"Khatiwada B, Nguyen TT, Purslow JA, Venditti V (2022) Solution structure ensemble of human obesity-associated protein FTO reveals druggable surface pockets at the interface between the N-and C-terminal domain. J Biol Chem 298:101907","journal-title":"J Biol Chem"},{"key":"10401_CR44","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1093\/humupd\/dmi024","volume":"11","author":"HS Kok","year":"2005","unstructured":"Kok HS, VAN Asselt KM, VAN DER Schouw YT, Peeters PH, Wijmenga C (2005) Genetic studies to identify genes underlying menopausal age. Hum Reprod Update 11:483\u2013493","journal-title":"Hum Reprod Update"},{"key":"10401_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207447","volume":"21","author":"AM Leonetti","year":"2020","unstructured":"Leonetti AM, Chu MY, Ramnaraign FO, Holm S, Walters BJ (2020) An emerging role of m6A in memory: a case for translational priming. Int J Mol Sci 21:7447","journal-title":"Int J Mol Sci"},{"key":"10401_CR46","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.trecan.2022.02.010","volume":"8","author":"Y Li","year":"2022","unstructured":"Li Y, Su R, Deng X, Chen Y, Chen J (2022) FTO in cancer: functions, molecular mechanisms, and therapeutic implications. Trends Cancer 8:598\u2013614","journal-title":"Trends Cancer"},{"key":"10401_CR47","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s10522-022-09999-2","volume":"24","author":"N Li","year":"2023","unstructured":"Li N, Luo R, Zhang W, Wu Y, Hu C, Liu M, Jiang D, Jiang Z, Zhao X, Wang Y, Li Q (2023) IL-17A promotes endothelial cell senescence by up-regulating the expression of FTO through activating JNK signal pathway. Biogerontology 24:99\u2013110","journal-title":"Biogerontology"},{"key":"10401_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110809","volume":"27","author":"J Li","year":"2024","unstructured":"Li J, Yang Z, Song H, Yang L, Na K, Mei Z, Zhang S, Liu J, Xu K, Yan C, Wang X (2024a) The role of mitofusin 2 in regulating endothelial cell senescence: implications for vascular aging. iScience 27:110809","journal-title":"iScience"},{"key":"10401_CR49","doi-asserted-by":"publisher","first-page":"3498","DOI":"10.1007\/s43032-024-01632-6","volume":"31","author":"L Li","year":"2024","unstructured":"Li L, Yang L, Shen L, Zhao Y, Wang L, Zhang H (2024b) Fat mass and obesity-associated protein regulates granulosa cell aging by targeting matrix metalloproteinase-2 gene via an N6-methyladenosine-YT521-B homology domain family member 2-dependent pathway in aged mice. Reprod Sci 31:3498\u20133511","journal-title":"Reprod Sci"},{"key":"10401_CR50","first-page":"844","volume":"16","author":"P Li","year":"2024","unstructured":"Li P, Dou Q, Zhang D, Xiang Y, Tan L (2024c) Melatonin regulates autophagy in granulosa cells from patients with premature ovarian insufficiency via activating Foxo3a. Aging (Albany NY) 16:844\u2013856","journal-title":"Aging (Albany NY)"},{"key":"10401_CR51","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1491546","volume":"15","author":"Y Li","year":"2024","unstructured":"Li Y, Wang L, Liu J, Nie G, Yang H (2024d) Huyang Yangkun formula regulates the mitochondria pathway of ovarian granulosa cell apoptosis through FTO\/m6A-P53 pathway. Front Pharmacol 15:1491546","journal-title":"Front Pharmacol"},{"key":"10401_CR52","doi-asserted-by":"publisher","DOI":"10.1186\/s12993-025-00280-3","volume":"21","author":"M Li","year":"2025","unstructured":"Li M, Yang Y, Chen T, Luo Y, Zhang Y, Liu H, Maes M (2025a) FTO (fat-mass and obesity-associated protein) deficiency aggravates age-dependent depression-like behaviors and cognitive impairment. Behav Brain Funct 21:18","journal-title":"Behav Brain Funct"},{"key":"10401_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.142181","volume":"307","author":"Q Li","year":"2025","unstructured":"Li Q, Shen H, Liu A, Yu L, Wang L, Zhang X (2025b) FTO-mediated m6A modification elevates the MFN2 mRNA stability to suppress ovarian granulosa cell senescence. Int J Biol Macromol 307:142181","journal-title":"Int J Biol Macromol"},{"key":"10401_CR54","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1007\/s11427-012-4354-3","volume":"55","author":"X Liang","year":"2012","unstructured":"Liang X, Ma J, Schatten H, Sun Q (2012) Epigenetic changes associated with oocyte aging. Sci China Life Sci 55:670\u2013676","journal-title":"Sci China Life Sci"},{"key":"10401_CR55","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.jclinepi.2003.10.005","volume":"57","author":"L Lisabeth","year":"2004","unstructured":"Lisabeth L, Harlow S, Qaqish B (2004) A new statistical approach demonstrated menstrual patterns during the menopausal transition did not vary by age at menopause. J Clin Epidemiol 57:484\u2013496","journal-title":"J Clin Epidemiol"},{"key":"10401_CR56","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27044-7","volume":"12","author":"S Liu","year":"2021","unstructured":"Liu S, Xiu J, Zhu C, Meng K, Li C, Han R, Du T, Li L, Xu L, Liu R (2021) Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice. Nat Commun 12:6937","journal-title":"Nat Commun"},{"key":"10401_CR57","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.1345","volume":"12","author":"L Liu","year":"2024","unstructured":"Liu L, Liu M, Song Z, Zhang H (2024) Silencing of FTO inhibits oxidative stress to relieve neuropathic pain by m6A modification of GPR177. Immun Inflamm Dis 12:e1345","journal-title":"Immun Inflamm Dis"},{"key":"10401_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15489","volume":"9","author":"K Malekpour","year":"2023","unstructured":"Malekpour K, Hazrati A, Soudi S, Roshangar L, Pourfathollah AA, Ahmadi M (2023) Combinational administration of mesenchymal stem cell-derived exosomes and metformin reduces inflammatory responses in an in vitro model of insulin resistance in HepG2 cells. Heliyon 9:e15489","journal-title":"Heliyon"},{"key":"10401_CR59","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1530\/rep.0.1230023","volume":"123","author":"E Markstr\u00f6m","year":"2002","unstructured":"Markstr\u00f6m E, Svensson E, Shao R, Svanberg B, Billig H (2002) Survival factors regulating ovarian apoptosis -- dependence on follicle differentiation. Reproduction 123:23\u201330","journal-title":"Reproduction"},{"key":"10401_CR60","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1262\/jrd.2023-021","volume":"69","author":"N Maruyama","year":"2023","unstructured":"Maruyama N, Fukunaga I, Kogo T, Endo T, Fujii W, Kanai-Azuma M, Naito K, Sugiura K (2023) Accumulation of senescent cells in the stroma of aged mouse ovary. J Reprod Dev 69:328\u2013336","journal-title":"J Reprod Dev"},{"key":"10401_CR61","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/nature21022","volume":"541","author":"J Mauer","year":"2017","unstructured":"Mauer J, Luo X, Blanjoie A, Jiao X, Grozhik AV, Patil DP, Linder B, Pickering BF, Vasseur J-J, Chen Q (2017) Reversible methylation of m6Am in the 5\u2032 cap controls mRNA stability. Nature 541:371\u2013375","journal-title":"Nature"},{"key":"10401_CR62","first-page":"200","volume":"21","author":"EA Mcgee","year":"2000","unstructured":"Mcgee EA, Hsueh AJW (2000) Initial and Cyclic Recruitment of Ovarian Follicles*. Endocr Rev 21:200\u2013214","journal-title":"Endocr Rev"},{"key":"10401_CR63","doi-asserted-by":"crossref","unstructured":"MITSUHASHI, H. & NAGY, C. 2023. Potential Roles of m6A and FTO in Synaptic Connectivity and Major Depressive Disorder. Int J Mol Sci, 24.","DOI":"10.3390\/ijms24076220"},{"key":"10401_CR64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227063","volume":"14","author":"L Molina-Garc\u00eda","year":"2019","unstructured":"Molina-Garc\u00eda L, Hidalgo-Ruiz M, Cocera-Ru\u00edz EM, Conde-Puertas E, Delgado-Rodr\u00edguez M, Mart\u00ednez-Galiano JM (2019) The delay of motherhood: reasons, determinants, time used to achieve pregnancy, and maternal anxiety level. PLoS ONE 14:e0227063","journal-title":"PLoS ONE"},{"key":"10401_CR65","doi-asserted-by":"publisher","first-page":"eabc7409","DOI":"10.1126\/sciadv.abc7409","volume":"7","author":"JM Navarro-Pando","year":"2021","unstructured":"Navarro-Pando JM, Alcocer-G\u00f3mez E, Castej\u00f3n-Vega B, Navarro-Villar\u00e1n E, Cond\u00e9s-Herv\u00e1s M, Mundi-Roldan M, Muntan\u00e9 J, P\u00e9rez-Pulido AJ, Bullon P, Wang C, Hoffman HM, Sanz A, Mbalaviele G, Ryffel B, Cordero MD (2021) Inhibition of the NLRP3 inflammasome prevents ovarian aging. Sci Adv 7:eabc7409","journal-title":"Sci Adv"},{"key":"10401_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109093","volume":"324","author":"HR Nejabati","year":"2020","unstructured":"Nejabati HR, Samadi N, Shahnazi V, Mihanfar A, Fattahi A, Latifi Z, Bahrami-Asl Z, Roshangar L, Nouri M (2020a) Nicotinamide and its metabolite N1-methylnicotinamide alleviate endocrine and metabolic abnormalities in adipose and ovarian tissues in rat model of Polycystic Ovary Syndrome. Chem Biol Interact 324:109093","journal-title":"Chem Biol Interact"},{"key":"10401_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101131","volume":"62","author":"HR Nejabati","year":"2020","unstructured":"Nejabati HR, Schmeisser K, Shahnazi V, Samimifar D, Faridvand Y, Bahrami-Asl Z, Fathi-Maroufi N, Nikanfar S, Nouri M (2020b) N1-methylnicotinamide: an anti-ovarian aging hormetin? Ageing Res Rev 62:101131","journal-title":"Ageing Res Rev"},{"key":"10401_CR68","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.2174\/1381612829666230816100641","volume":"29","author":"HR Nejabati","year":"2023","unstructured":"Nejabati HR, Nikzad S, Roshangar L (2023a) Alleviative effects of adipose tissue-derived stem cells and \u03b1-NETA on metabolic, biochemical, and endocrine parameters in a Letrozole-induced rat model of PCOS. Curr Pharm des 29:1929\u20131938","journal-title":"Curr Pharm des"},{"key":"10401_CR69","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cca.2022.11.003","volume":"538","author":"HR Nejabati","year":"2023","unstructured":"Nejabati HR, Roshangar L, Nouri M (2023b) Follicular fluid extracellular vesicle miRNAs and ovarian aging. Clin Chim Acta 538:29\u201335","journal-title":"Clin Chim Acta"},{"key":"10401_CR70","doi-asserted-by":"publisher","first-page":"134","DOI":"10.2174\/1574888X18666230517123256","volume":"19","author":"HR Nejabati","year":"2024","unstructured":"Nejabati HR, Nikzad S, Roshangar L (2024) Therapeutic potential of mesenchymal stem cells in PCOS. Curr Stem Cell Res Ther 19:134\u2013144","journal-title":"Curr Stem Cell Res Ther"},{"key":"10401_CR71","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoad007","volume":"2023","author":"P Njagi","year":"2023","unstructured":"Njagi P, Groot W, Arsenijevic J, Dyer S, Mburu G, Kiarie J (2023) Financial costs of assisted reproductive technology for patients in low- and middle-income countries: a systematic review. Hum Reprod Open 2023:hoad007","journal-title":"Hum Reprod Open"},{"key":"10401_CR72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0318780","volume":"20","author":"P Njagi","year":"2025","unstructured":"Njagi P, Groot W, Arsenijevic J, Mburu G, Chambers G, Calhaz-Jorge C, Kiarie J (2025) Financial cost of assisted reproductive technology for patients in high-income countries: a systematic review protocol. PLoS ONE 20:e0318780","journal-title":"PLoS ONE"},{"key":"10401_CR73","doi-asserted-by":"publisher","first-page":"R19","DOI":"10.1530\/REP-21-0022","volume":"162","author":"SU Park","year":"2021","unstructured":"Park SU, Walsh L, Berkowitz KM (2021) Mechanisms of ovarian aging. Reproduction 162:R19-r33","journal-title":"Reproduction"},{"key":"10401_CR74","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.127381","volume":"92","author":"E Pelosi","year":"2015","unstructured":"Pelosi E, Simonsick E, Forabosco A, Garcia-Ortiz JE, Schlessinger D (2015) Dynamics of the ovarian reserve and impact of genetic and epidemiological factors on age of menopause. Biol Reprod 92:130","journal-title":"Biol Reprod"},{"key":"10401_CR75","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.cell.2017.05.003","volume":"169","author":"KE Pendleton","year":"2017","unstructured":"Pendleton KE, Chen B, Liu K, Hunter OV, Xie Y, Tu BP, Conrad NK (2017) The U6 snRNA m(6)A methyltransferase METTL16 regulates SAM synthetase intron retention. Cell 169:824-835.e14","journal-title":"Cell"},{"key":"10401_CR76","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/5985","volume":"21","author":"GI Perez","year":"1999","unstructured":"Perez GI, Robles R, Knudson CM, Flaws JA, Korsmeyer SJ, Tilly JL (1999) Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency. Nat Genet 21:200\u2013203","journal-title":"Nat Genet"},{"key":"10401_CR77","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1007\/s003359901144","volume":"10","author":"T Peters","year":"1999","unstructured":"Peters T, Ausmeier K, R\u00fcther U (1999) Cloning of fatso (Fto), a novel gene deleted by the fused toes (Ft) mouse mutation. Mamm Genome 10:983\u2013986","journal-title":"Mamm Genome"},{"key":"10401_CR1","doi-asserted-by":"crossref","unstructured":"Practice Committee of the American Society for Reproductive Medicine (2015). Testing and interpreting measures of ovarian reserve: a committee opinion. Fertil Steril 103(3):e9\u2013e17","DOI":"10.1016\/j.fertnstert.2014.12.093"},{"key":"10401_CR78","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.mam.2013.06.001","volume":"38","author":"J Qiao","year":"2014","unstructured":"Qiao J, Wang ZB, Feng HL, Miao YL, Wang Q, Yu Y, Wei YC, Yan J, Wang WH, Shen W, Sun SC, Schatten H, Sun QY (2014) The root of reduced fertility in aged women and possible therapentic options: current status and future perspects. Mol Aspects Med 38:54\u201385","journal-title":"Mol Aspects Med"},{"key":"10401_CR79","doi-asserted-by":"publisher","DOI":"10.3390\/nu14061244","author":"C Raftopoulou","year":"2022","unstructured":"Raftopoulou C, Paltoglou G, Charmandari E (2022) Association between telomere length and pediatric obesity: a systematic review. Nutrients. https:\/\/doi.org\/10.3390\/nu14061244","journal-title":"Nutrients"},{"key":"10401_CR80","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21758-4","volume":"12","author":"S Relier","year":"2021","unstructured":"Relier S, Ripoll J, Guillorit H, Amalric A, Achour C, Boissi\u00e8re F, Vialaret J, Attina A, Debart F, Choquet A (2021) FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell. Nat Commun 12:1716","journal-title":"Nat Commun"},{"key":"10401_CR81","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/humupd\/dmr040","volume":"18","author":"L Schmidt","year":"2012","unstructured":"Schmidt L, Sobotka T, Bentzen JG, Nyboe Andersen A (2012) Demographic and medical consequences of the postponement of parenthood. Hum Reprod Update 18:29\u201343","journal-title":"Hum Reprod Update"},{"key":"10401_CR82","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1056\/NEJM198202183060706","volume":"306","author":"D Schwartz","year":"1982","unstructured":"Schwartz D, Mayaux MJ (1982) Female fecundity as a function of age: results of artificial insemination in 2193 nulliparous women with azoospermic husbands. Federation CECOS. N Engl J Med 306:404\u2013406","journal-title":"N Engl J Med"},{"key":"10401_CR83","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.15252\/embj.201593084","volume":"35","author":"D Sebasti\u00e1n","year":"2016","unstructured":"Sebasti\u00e1n D, Sorianello E, Segal\u00e9s J, Irazoki A, Ruiz-Bonilla V, Sala D, Planet E, Berenguer-Llergo A, Mu\u00f1oz JP, S\u00e1nchez-Feutrie M, Plana N, Hern\u00e1ndez-\u00c1lvarez MI, Serrano AL, Palac\u00edn M, Zorzano A (2016) Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway. EMBO J 35:1677\u20131693","journal-title":"EMBO J"},{"key":"10401_CR84","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-020-02249-z","volume":"22","author":"AM Shafik","year":"2021","unstructured":"Shafik AM, Zhang F, Guo Z, Dai Q, Pajdzik K, Li Y, Kang Y, Yao B, Wu H, He C, Allen EG, Duan R, Jin P (2021) N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer\u2019s disease. Genome Biol 22:17","journal-title":"Genome Biol"},{"key":"10401_CR85","doi-asserted-by":"publisher","DOI":"10.1016\/j.advnut.2024.100273","volume":"15","author":"Y Shang","year":"2024","unstructured":"Shang Y, Song N, He R, Wu M (2024) Antioxidants and fertility in women with ovarian aging: a systematic review and meta-analysis. Adv Nutr 15:100273","journal-title":"Adv Nutr"},{"key":"10401_CR86","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1242\/dmm.008698","volume":"4","author":"JR Speakman","year":"2011","unstructured":"Speakman JR, Levitsky DA, Allison DB, Bray MS, De Castro JM, Clegg DJ, Clapham JC, Dulloo AG, Gruer L, Haw S, Hebebrand J, Hetherington MM, Higgs S, Jebb SA, Loos RJ, Luckman S, Luke A, Mohammed-Ali V, O\u2019rahilly S, Pereira M, Perusse L, Robinson TN, Rolls B, Symonds ME, Westerterp-Plantenga MS (2011) Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity. Dis Model Mech 4:733\u2013745","journal-title":"Dis Model Mech"},{"key":"10401_CR87","doi-asserted-by":"publisher","first-page":"190","DOI":"10.5152\/jtgga.2014.0022","volume":"15","author":"YE S\u00fck\u00fcr","year":"2014","unstructured":"S\u00fck\u00fcr YE, K\u0131VAN\u00c7L\u0131 IB, Ozmen B (2014) Ovarian aging and premature ovarian failure. J Turk Ger Gynecol Assoc 15:190\u2013196","journal-title":"J Turk Ger Gynecol Assoc"},{"key":"10401_CR88","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1007\/s00404-020-05895-7","volume":"303","author":"X Sun","year":"2021","unstructured":"Sun X, Zhang Y, Hu Y, An J, Li L, Wang Y, Zhang X (2021) Decreased expression of m6A demethylase FTO in ovarian aging. Arch Gynecol Obstet 303:1363\u20131369","journal-title":"Arch Gynecol Obstet"},{"key":"10401_CR89","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.942","volume":"12","author":"Q Sun","year":"2022","unstructured":"Sun Q, Geng H, Zhao M, Li Y, Chen X, Sha Q, Lai P, Tang D, Yang D, Liang J (2022) FTO-mediated m6A modification of SOCS1 mRNA promotes the progression of diabetic kidney disease. Clin Transl Med 12:e942","journal-title":"Clin Transl Med"},{"key":"10401_CR90","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.fertnstert.2012.11.029","volume":"99","author":"C Tatone","year":"2013","unstructured":"Tatone C, Amicarelli F (2013) The aging ovary\u2013the poor granulosa cells. Fertil Steril 99:12\u201317","journal-title":"Fertil Steril"},{"key":"10401_CR91","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1093\/humupd\/dmm048","volume":"14","author":"C Tatone","year":"2008","unstructured":"Tatone C, Amicarelli F, Carbone MC, Monteleone P, Caserta D, Marci R, Artini PG, Piomboni P, Focarelli R (2008) Cellular and molecular aspects of ovarian follicle ageing. Hum Reprod Update 14:131\u2013142","journal-title":"Hum Reprod Update"},{"key":"10401_CR2","unstructured":"TU Consortium (2022) UniProt: the universal protein knowledgebase in 2023. Nucleic Acids Res 51(D1):D523-D531"},{"key":"10401_CR92","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1136\/bmj.302.6789.1361","volume":"302","author":"BM Van Noord-Zaadstra","year":"1991","unstructured":"Van Noord-Zaadstra BM, Looman CW, Alsbach H, Habbema JD, te Velde ER, Karbaat J (1991) Delaying childbearing: effect of age on fecundity and outcome of pregnancy. BMJ 302:1361\u20131365","journal-title":"BMJ"},{"key":"10401_CR93","first-page":"3421","volume":"86","author":"TE Vaskivuo","year":"2001","unstructured":"Vaskivuo TE, Anttonen M, Herva R, Billig HK, Dorland M, Te Velde ER, Stenb\u00e4ck F, Heikinheimo M, Tapanainen JS (2001) Survival of human ovarian follicles from fetal to adult life: apoptosis, apoptosis-related proteins, and transcription factor GATA-41. J Clin Endocrinol Metab 86:3421\u20133429","journal-title":"J Clin Endocrinol Metab"},{"key":"10401_CR94","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nrm2147","volume":"8","author":"KH Vousden","year":"2007","unstructured":"Vousden KH, Lane DP (2007) P53 in health and disease. Nat Rev Mol Cell Biol 8:275\u2013283","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10401_CR95","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1161\/HYPERTENSIONAHA.114.03618","volume":"65","author":"M Wang","year":"2015","unstructured":"Wang M, Kim SH, Monticone RE, Lakatta EG (2015) Matrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis. Hypertension 65:698\u2013703","journal-title":"Hypertension"},{"key":"10401_CR96","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.cell.2020.01.009","volume":"180","author":"S Wang","year":"2020","unstructured":"Wang S, Zheng Y, Li J, Yu Y, Zhang W, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Ma L, Esteban CR, Chan P, Qiao J, Zhou Q, Izpisua Belmonte JC, Qu J, Tang F, Liu GH (2020) Single-cell transcriptomic atlas of primate ovarian aging. Cell 180:585-600.e19","journal-title":"Cell"},{"key":"10401_CR97","first-page":"1279","volume":"26","author":"T Wang","year":"2021","unstructured":"Wang T, Li W, Ye B, Zhang S, Lei X, Zhang D (2021) FTO-stabilized lncRNA HOXC13-AS epigenetically upregulated FZD6 and activated Wnt\/\u03b2-catenin signaling to drive cervical cancer proliferation, invasion, and EMT. J BUON 26:1279\u20131291","journal-title":"J BUON"},{"key":"10401_CR98","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13568","volume":"21","author":"P Wasserzug-Pash","year":"2022","unstructured":"Wasserzug-Pash P, Rothman R, Reich E, Zecharyahu L, Schonberger O, Weiss Y, Srebnik N, Cohen-Hadad Y, Weintraub A, Ben-Ami I, Holzer H, Klutstein M (2022) Loss of heterochromatin and retrotransposon silencing as determinants in oocyte aging. Aging Cell 21:e13568","journal-title":"Aging Cell"},{"key":"10401_CR99","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.molcel.2018.08.011","volume":"71","author":"J Wei","year":"2018","unstructured":"Wei J, Liu F, Lu Z, Fei Q, Ai Y, He PC, Shi H, Cui X, Su R, Klungland A (2018) Differential m6A, m6Am, and m1A demethylation mediated by FTO in the cell nucleus and cytoplasm. Mol Cell 71:973-985. e5","journal-title":"Mol Cell"},{"key":"10401_CR100","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.134969","volume":"476","author":"Y Wen","year":"2024","unstructured":"Wen Y, Fu Z, Li J, Liu M, Wang X, Chen J, Chen Y, Wang H, Wen S, Zhang K, Deng Y (2024) Targeting m(6)A mRNA demethylase FTO alleviates manganese-induced cognitive memory deficits in mice. J Hazard Mater 476:134969","journal-title":"J Hazard Mater"},{"key":"10401_CR101","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.neuron.2017.12.036","volume":"97","author":"YL Weng","year":"2018","unstructured":"Weng YL, Wang X, An R, Cassin J, Vissers C, Liu Y, Liu Y, Xu T, Wang X, Wong SZH, Joseph J, Dore LC, Dong Q, Zheng W, Jin P, Wu H, Shen B, Zhuang X, He C, Liu K, Song H, Ming GL (2018) Epitranscriptomic m(6)A regulation of axon regeneration in the adult mammalian nervous system. Neuron 97:313-325.e6","journal-title":"Neuron"},{"key":"10401_CR102","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202052348","volume":"22","author":"R Wu","year":"2021","unstructured":"Wu R, Chen Y, Liu Y, Zhuang L, Chen W, Zeng B, Liao X, Guo G, Wang Y, Wang X (2021) M6A methylation promotes white-to-beige fat transition by facilitating Hif1a translation. EMBO Rep 22:e52348","journal-title":"EMBO Rep"},{"key":"10401_CR103","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110505","author":"L Xu","year":"2024","unstructured":"Xu L, Chen Y, Wu T, Fan J, Hu Y, Gao X, Wang Y, Chen T, Zhao X, Zeng M (2024) DNA damage-mediated FTO downregulation promotes CRPC progression by inhibiting FOXO3a via an m6A-dependent mechanism. Iscience. https:\/\/doi.org\/10.1016\/j.isci.2024.110505","journal-title":"Iscience"},{"key":"10401_CR104","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-022-01032-x","volume":"15","author":"F Yan","year":"2022","unstructured":"Yan F, Zhao Q, Li Y, Zheng Z, Kong X, Shu C, Liu Y, Shi Y (2022) The role of oxidative stress in ovarian aging: a review. J Ovarian Res 15:100","journal-title":"J Ovarian Res"},{"key":"10401_CR105","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41417-020-0193-8","volume":"28","author":"Z Yang","year":"2021","unstructured":"Yang Z, Jiang X, Zhang Z, Zhao Z, Xing W, Liu Y, Jiang X, Zhao H (2021) Hdac3-dependent transcriptional repression of FOXA2 regulates FTO\/m6A\/MYC signaling to contribute to the development of gastric cancer. Cancer Gene Ther 28:141\u2013155","journal-title":"Cancer Gene Ther"},{"key":"10401_CR106","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1007\/s11427-023-2527-5","volume":"67","author":"H Yang","year":"2024","unstructured":"Yang H, Xuan L, Wang S, Luo H, Duan X, Guo J, Cui S, Xin J, Hao J, Li X (2024) LncRNA CCRR maintains Ca2+ homeostasis against myocardial infarction through the FTO-SERCA2a pathway. Sci China Life Sci 67:1601\u20131619","journal-title":"Sci China Life Sci"},{"key":"10401_CR107","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1017\/S0007114523000764","volume":"130","author":"D Yin","year":"2023","unstructured":"Yin D, Li Y, Liao X, Tian D, Xu Y, Zhou C, Liu J, Li S, Zhou J, Nie Y (2023) FTO: a critical role in obesity and obesity-related diseases. Br J Nutr 130:1657\u20131664","journal-title":"Br J Nutr"},{"key":"10401_CR108","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1007\/s43032-025-01873-z","volume":"32","author":"J Ying","year":"2025","unstructured":"Ying J, Zhang X, Sun X, Meng Q (2025) Decreased FTO expression promotes ovarian granulosa cells aging. Reprod Sci 32:1987\u20131997","journal-title":"Reprod Sci"},{"key":"10401_CR109","volume":"15","author":"S Zabak","year":"2023","unstructured":"Zabak S, Varma A, Bansod S, Pohane MR (2023) Exploring the complex landscape of delayed childbearing: factors, history, and long-term implications. Cureus 15:e46291","journal-title":"Cureus"},{"key":"10401_CR110","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167307","volume":"1870","author":"H Zeng","year":"2024","unstructured":"Zeng H, Xu J, Wu R, Wang X, Jiang Y, Wang Q, Guo J, Xiao F (2024) FTO alleviated ferroptosis in septic cardiomyopathy via mediating the m6A modification of BACH1. Biochimica Et Biophysica Acta (BBA) 1870:167307","journal-title":"Biochimica Et Biophysica Acta (BBA)"},{"key":"10401_CR111","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.molcel.2018.10.029","volume":"72","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Yan Z, Qin Q, Nisenblat V, Chang HM, Yu Y, Wang T, Lu C, Yang M, Yang S, Yao Y, Zhu X, Xia X, Dang Y, Ren Y, Yuan P, Li R, Liu P, Guo H, Han J, He H, Zhang K, Wang Y, Wu Y, Li M, Qiao J, Yan J, Yan L (2018) Transcriptome landscape of human folliculogenesis reveals oocyte and granulosa cell interactions. Mol Cell 72:1021-1034.e4","journal-title":"Mol Cell"},{"key":"10401_CR112","doi-asserted-by":"publisher","first-page":"17980","DOI":"10.1073\/pnas.1905489116","volume":"116","author":"Q Zhang","year":"2019","unstructured":"Zhang Q, Riddle RC, Yang Q, Rosen CR, Guttridge DC, Dirckx N, Faugere M-C, Farber CR, Clemens TL (2019) The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage. Proc Natl Acad Sci U S A 116:17980\u201317989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10401_CR113","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2024.110072","volume":"758","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Chen Y, Guo Q, Zhang Y, Liu A (2024) Fat mass and obesity-associated protein (FTO)-induced upregulation of flotillin-2 (FLOT2) contributes to cancer aggressiveness in diffuse large B-cell lymphoma (DLBCL) via activating the PI3K\/Akt\/mTOR signal pathway. Arch Biochem Biophys 758:110072","journal-title":"Arch Biochem Biophys"},{"key":"10401_CR114","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1038\/cr.2014.151","volume":"24","author":"X Zhao","year":"2014","unstructured":"Zhao X, Yang Y, Sun B-F, Shi Y, Yang X, Xiao W, Hao Y-J, Ping X-L, Chen Y-S, Wang W-J (2014) FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Res 24:1403\u20131419","journal-title":"Cell Res"},{"key":"10401_CR115","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nrm.2016.132","volume":"18","author":"BS Zhao","year":"2017","unstructured":"Zhao BS, Roundtree IA, He C (2017) Post-transcriptional gene regulation by mRNA modifications. Nat Rev Mol Cell Biol 18:31\u201342","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10401_CR116","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0372-6","volume":"24","author":"Y Zhou","year":"2017","unstructured":"Zhou Y, Hambly BD, Mclachlan CS (2017a) FTO associations with obesity and telomere length. J Biomed Sci 24:65","journal-title":"J Biomed Sci"},{"key":"10401_CR117","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1038\/ijo.2017.127","volume":"41","author":"Y Zhou","year":"2017","unstructured":"Zhou Y, Simmons D, Lai D, Hambly BD, McLachlan CS (2017b) Rs9939609 FTO genotype associations with FTO methylation level influences body mass and telomere length in an Australian rural population. Int J Obes (Lond) 41:1427\u20131433","journal-title":"Int J Obes (Lond)"},{"key":"10401_CR118","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04503-7","volume":"13","author":"Y Zhou","year":"2022","unstructured":"Zhou Y, Wang Q, Deng H, Xu B, Zhou Y, Liu J, Liu Y, Shi Y, Zheng X, Jiang J (2022) N6-methyladenosine demethylase FTO promotes growth and metastasis of gastric cancer via m(6)A modification of caveolin-1 and metabolic regulation of mitochondrial dynamics. Cell Death Dis 13:72","journal-title":"Cell Death Dis"}],"container-title":["Biogerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-026-10401-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10522-026-10401-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-026-10401-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T10:02:52Z","timestamp":1775642572000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10522-026-10401-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,6]]},"references-count":118,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10401"],"URL":"https:\/\/doi.org\/10.1007\/s10522-026-10401-8","relation":{},"ISSN":["1389-5729","1573-6768"],"issn-type":[{"value":"1389-5729","type":"print"},{"value":"1573-6768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,6]]},"assertion":[{"value":"29 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"53"}}