{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:31:04Z","timestamp":1789047064043,"version":"build-2803163510"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biogerontology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s10522-026-10460-x","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:53:13Z","timestamp":1780923193000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Kaempferol as an ovarian aging-modulatory flavonol\u202c"],"prefix":"10.1007","volume":"27","author":[{"given":"Hamid Reza","family":"Nejabati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Roshangar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"issue":"10","key":"10460_CR1","doi-asserted-by":"publisher","first-page":"8630","DOI":"10.3390\/ijms24108630","volume":"24","author":"A Almatroudi","year":"2023","unstructured":"Almatroudi A, Allemailem KS, Alwanian WM, Alharbi BF, Alrumaihi F, Khan AA, Almatroodi SA, Rahmani AH (2023) Effects and mechanisms of Kaempferol in the management of cancers through modulation of inflammation and signal transduction pathways. Internat J Mol Sci 24(10):8630","journal-title":"Internat J Mol Sci"},{"key":"10460_CR2","doi-asserted-by":"publisher","first-page":"9580","DOI":"10.1080\/10408398.2022.2067121","volume":"63","author":"SP Bangar","year":"2022","unstructured":"Bangar SP, Chaudhary V, Sharma N, Bansal V, Ozogul F, Lorenzo JM (2022) Kaempferol: a flavonoid with wider biological activities and its applications. Crit Rev Food Sci Nutr 63:9580\u20139604","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10460_CR3","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1590\/1678-4162-12608","volume":"74","author":"L Barbosa","year":"2022","unstructured":"Barbosa L, Barberino R, Gouveia B, Menezes V, Palheta Junior R, Matos M (2022) Protective effect of kaempferol against cisplatin-induced acute ovarian damage in a mouse model. Arquivo Brasileiro De Medicina Veterinaria e Zootecnia 74:778\u2013784","journal-title":"Arquivo Brasileiro De Medicina Veterinaria e Zootecnia"},{"key":"10460_CR4","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1210\/er.2009-0006","volume":"30","author":"FJ Broekmans","year":"2009","unstructured":"Broekmans FJ, Soules MR, FauseR BC (2009) Ovarian aging: mechanisms and clinical consequences. Endocr Rev 30:465\u2013493","journal-title":"Endocr Rev"},{"key":"10460_CR5","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3390\/antiox9020149","volume":"9","author":"ML Castej\u00f3n","year":"2020","unstructured":"Castej\u00f3n ML, Montoya T, Alarc\u00f3n-de-la-Lastra C, S\u00e1nchez-Hidalgo M (2020) Potential protective role exerted by secoiridoids from Olea europaea L. in Cancer, cardiovascular, neurodegenerative, aging-related, and immunoinflammatory diseases. Antioxidants (Basel) 9:149","journal-title":"Antioxidants (Basel)"},{"key":"10460_CR6","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.cmet.2015.05.013","volume":"22","author":"NS Chandel","year":"2015","unstructured":"Chandel NS (2015) Evolution of mitochondria as signaling organelles. Cell Metab 22:204\u2013206","journal-title":"Cell Metab"},{"key":"10460_CR7","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1902\/jop.2012.120180","volume":"84","author":"IS Choi","year":"2013","unstructured":"Choi IS, Choi EY, Jin JY, Park HR, Choi JI, Kim SJ (2013) Kaempferol inhibits P. intermedia lipopolysaccharide-induced production of nitric oxide through translational regulation in murine macrophages: critical role of heme oxygenase-1-mediated ROS reduction. J Periodontol 84:545\u2013555","journal-title":"J Periodontol"},{"issue":"38","key":"10460_CR8","doi-asserted-by":"publisher","first-page":"9960","DOI":"10.1021\/acs.jafc.8b02656","volume":"66","author":"JB Choi","year":"2018","unstructured":"Choi JB, Kim JH, Lee H, Pak JN, Shim BS, Kim SH (2018) Reactive oxygen species and p53 mediated activation of p38 and caspases is critically involved in kaempferol induced apoptosis in colorectal cancer cells. J Agri Food Chem 66(38):9960\u20139967","journal-title":"J Agri Food Chem"},{"key":"10460_CR9","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1093\/geroni\/igab046.1440","volume":"5","author":"C Cortes","year":"2021","unstructured":"Cortes C (2021) Exercise-associated pathways as novel neuroprotectants against CNS aging and Alzheimer\u2019s disease. Innov Aging 5:371","journal-title":"Innov Aging"},{"key":"10460_CR10","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s10522-011-9326-7","volume":"12","author":"D Demirovic","year":"2011","unstructured":"Demirovic D, Rattan SI (2011) Curcumin induces stress response and hormetically modulates wound healing ability of human skin fibroblasts undergoing ageing in vitro. Biogerontology 12:437\u2013444","journal-title":"Biogerontology"},{"issue":"4","key":"10460_CR11","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s10815-022-02418-y","volume":"39","author":"V Di Nisio","year":"2022","unstructured":"Di Nisio V, Antonouli S, Damdimopoulou P, Salumets A, Cecconi S (2022) In vivo and in vitro postovulatory aging: when time works against oocyte quality? J Ass Reproduct Genet 39(4):905\u2013918","journal-title":"J Ass Reproduct Genet"},{"key":"10460_CR12","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.fertnstert.2011.05.056","volume":"96","author":"HE Duran","year":"2011","unstructured":"Duran HE, Simsek-Duran F, Oehninger SC, Jones HW, Castora FJ (2011) The association of reproductive senescence with mitochondrial quantity, function, and DNA integrity in human oocytes at different stages of maturation. Fertil Steril 96:384\u2013388","journal-title":"Fertil Steril"},{"key":"10460_CR13","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.fct.2017.05.043","volume":"106","author":"AK Dwivedy","year":"2017","unstructured":"Dwivedy AK, Prakash B, Chanotiya CS, Bisht D, Dubey NK (2017) Chemically characterized Mentha cardiaca L. essential oil as plant based preservative in view of efficacy against biodeteriorating fungi of dry fruits, aflatoxin secretion, lipid peroxidation and safety profile assessment. Food Chem Toxicol 106:175\u2013184","journal-title":"Food Chem Toxicol"},{"key":"10460_CR14","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.ijpharm.2019.05.034","volume":"565","author":"HM Ezzat","year":"2019","unstructured":"Ezzat HM, ElnaggaR YSR, Abdallah OY (2019) Improved oral bioavailability of the anticancer drug catechin using chitosomes: design, in-vitro appraisal and in-vivo studies. Int J Pharm 565:488\u2013498","journal-title":"Int J Pharm"},{"issue":"12","key":"10460_CR15","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.3390\/nu9121301","volume":"9","author":"Y Fang","year":"2017","unstructured":"Fang Y, Cao W, Xia M, Pan S, Xu X (2017) Study of structure and permeability relationship of flavonoids in caco-2 cells. Nutrients 9(12):1301","journal-title":"Nutrients"},{"issue":"16","key":"10460_CR16","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1055\/s-0033-1350808","volume":"79","author":"K F\u00fcrer","year":"2013","unstructured":"F\u00fcrer K, Raith M, Brenneisen R, Mennet M, Sim\u00f5es-W\u00fcst AP, von Mandach U, Hamburger M, Potterat O (2013) Two new flavonol glycosides and a metabolite profile of Bryophyllum pinnatum, a phytotherapeutic used in obstetrics and gynaecology. Planta Med 79(16):1565\u20131571","journal-title":"Planta Med"},{"key":"10460_CR17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0300-483X(02)00198-1","volume":"177","author":"G Galati","year":"2002","unstructured":"Galati G, Sabzevari O, Wilson JX, O\u2019Brien PJ (2002) Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology 177:91\u2013104","journal-title":"Toxicology"},{"key":"10460_CR18","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1093\/molehr\/5.3.227","volume":"5","author":"PT Goud","year":"1999","unstructured":"Goud PT, Goud AP, Laverge H, De Sutter P, Dhont M (1999) Effect of post-ovulatory age and calcium in the injection medium on the male pronucleus formation and metaphase entry following injection of human spermatozoa into golden hamster oocytes. Mol Hum Reprod 5:227\u2013233","journal-title":"Mol Hum Reprod"},{"key":"10460_CR19","first-page":"174","volume":"3","author":"A Guaadaoui","year":"2014","unstructured":"Guaadaoui A, Benaicha S, Elmajdoub N, Bellaoui M (2014) What is a bioactive compound? A combined definition for a preliminary consensus. Int J Nutr Food Sci 3:174\u2013179","journal-title":"Int J Nutr Food Sci"},{"key":"10460_CR20","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.ejphar.2015.05.056","volume":"761","author":"Z Guo","year":"2015","unstructured":"Guo Z, Liao Z, Huang L, Liu D, Yin D, He M (2015) Kaempferol protects cardiomyocytes against anoxia\/reoxygenation injury via mitochondrial pathway mediated by SIRT1. Eur J Pharmacol 761:245\u2013253","journal-title":"Eur J Pharmacol"},{"key":"10460_CR21","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1093\/geronj\/11.3.298","volume":"11","author":"D Harman","year":"1956","unstructured":"Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11:298\u2013300","journal-title":"J Gerontol"},{"issue":"2","key":"10460_CR22","doi-asserted-by":"publisher","first-page":"180","DOI":"10.3390\/antiox9020180","volume":"9","author":"S Hofer","year":"2020","unstructured":"Hofer S, Geisler S, Lisandrelli R, Nguyen Ngoc H, Ganzera M, Schennach H, Fuchs D, Fuchs JE, Gostner JM, Kurz K (2020) Pharmacological targets of kaempferol within inflammatory pathways\u2014A hint towards the central role of tryptophan metabolism. Antioxidants 9(2):180","journal-title":"Antioxidants"},{"key":"10460_CR23","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.14385","volume":"103","author":"Z Hua","year":"2024","unstructured":"Hua Z, Zhang W, Han L, Zhang Y, Jiang X, Ding C (2024) Kaempferol exerts antioxidant effects in age-related diminished ovarian reserve by regulating the HSP90\/NRF2 pathway. Chem Biol Drug des 103:e14385","journal-title":"Chem Biol Drug des"},{"key":"10460_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2024.112389","volume":"188","author":"MS Hussain","year":"2024","unstructured":"Hussain MS, Altamimi ASA, Afzal M, Almalki WH, Kazmi I, Alzarea SI, Gupta G, Shahwan M, Kukreti N, Wong LS, Kumarasamy V, Subramaniyan V (2024) Kaempferol: paving the path for advanced treatments in aging-related diseases. Exp Gerontol 188:112389","journal-title":"Exp Gerontol"},{"issue":"8","key":"10460_CR25","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.3390\/ijms20081844","volume":"20","author":"M Jani\u0107","year":"2019","unstructured":"Jani\u0107 M, Lunder M, Novakovi\u0107 S, \u0160kerl P, \u0160abovi\u010d M (2019) Expression of longevity genes induced by a low-dose fluvastatin and valsartan combination with the potential to prevent\/treat \u201caging-related disorders.\u201d Internat J Mol Sci 20(8):1844","journal-title":"Internat J Mol Sci"},{"issue":"1","key":"10460_CR26","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s43188-023-00206-z","volume":"40","author":"SJ Jeon","year":"2024","unstructured":"Jeon SJ, Jung GH, Choi EY, Han EJ, Lee JH, Han SH, Woo JS, Jung SH, Jung JY (2024) Kaempferol induces apoptosis through the MAPK pathway and regulates JNK-mediated autophagy in MC-3 cells. Toxicol Res 40(1):45\u201355","journal-title":"Toxicol Res"},{"key":"10460_CR27","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.foodchem.2015.03.024","volume":"183","author":"H Jiang","year":"2015","unstructured":"Jiang H, Engelhardt UH, Thr\u00e4ne C, Maiwald B, Stark J (2015) Determination of flavonol glycosides in green tea, oolong tea and black tea by UHPLC compared to HPLC. Food Chem 183:30\u201335","journal-title":"Food Chem"},{"issue":"2","key":"10460_CR28","doi-asserted-by":"publisher","first-page":"bqaa01","DOI":"10.1210\/endocr\/bqaa001","volume":"161","author":"I Kasapo\u011flu","year":"2020","unstructured":"Kasapo\u011flu I, Seli E (2020) Mitochondrial dysfunction and ovarian aging. Endocrinology 161(2):bqaa01","journal-title":"Endocrinology"},{"key":"10460_CR29","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.4161\/cbt.7.7.6164","volume":"7","author":"B-W Kim","year":"2008","unstructured":"Kim B-W, Lee E-R, Min H-M, Jeong H-S, Ahn J-Y, Kim J-H, Choi H-Y, Choi H, Kim EY, Park SP (2008) Sustained ERK activation is involved in the kaempferol-induced apoptosis of breast cancer cells and is more evident under 3-D culture condition. Cancer Biol Ther 7:1080\u20131089","journal-title":"Cancer Biol Ther"},{"issue":"12","key":"10460_CR30","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.3390\/cells12121568","volume":"12","author":"R Kubina","year":"2023","unstructured":"Kubina R, Krzykawski K, Dziedzic A, Kaba\u0142a-Dzik A (2023) Kaempferol and Fisetin-related signaling pathways induce apoptosis in head and neck cancer cells. Cells 12(12):1568","journal-title":"Cells"},{"key":"10460_CR31","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/S0093-691X(00)00391-5","volume":"54","author":"WR Lamberson","year":"2000","unstructured":"Lamberson WR, Safranski TJ (2000) A model for economic comparison of swine insemination programs. Theriogenology 54:799\u2013807","journal-title":"Theriogenology"},{"key":"10460_CR32","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s00394-007-0670-y","volume":"46","author":"C Lemos","year":"2007","unstructured":"Lemos C, Peters GJ, Jansen G, Martel F, Calhau C (2007) Modulation of folate uptake in cultured human colon adenocarcinoma Caco-2 cells by dietary compounds. Eur J Nutr 46:329\u2013336","journal-title":"Eur J Nutr"},{"key":"10460_CR33","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1093\/humupd\/dmw028","volume":"22","author":"P May-Panloup","year":"2016","unstructured":"May-Panloup P, Boucret L, Chao de la Barca JM, Desquiret-Dumas V, Ferr\u00e9-L\u2019hotellier V, Morini\u00e8re C, Descamps P, Procaccio V, Reynier P (2016) Ovarian ageing: the role of mitochondria in oocytes and follicles. Hum Reprod Update 22:725\u2013743","journal-title":"Hum Reprod Update"},{"key":"10460_CR34","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1016\/j.fertnstert.2012.08.012","volume":"98","author":"S Mcreynolds","year":"2012","unstructured":"Mcreynolds S, Dzieciatkowska M, Mccallie BR, Mitchell SD, Stevens J, Hansen K, SchoolcrafT WB, Katz-Jaffe MG (2012) Impact of maternal aging on the molecular signature of human cumulus cells. Fertil Steril 98:1574\u201380.e5","journal-title":"Fertil Steril"},{"key":"10460_CR35","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1080\/1071576021000016463","volume":"36","author":"L Mira","year":"2002","unstructured":"Mira L, Fernandez MT, Santos M, Rocha R, Flor\u00eancio MH, Jennings KR (2002) Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity. Free Radic Res 36:1199\u20131208","journal-title":"Free Radic Res"},{"key":"10460_CR36","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14375","volume":"46","author":"HR Nejabati","year":"2022","unstructured":"Nejabati HR, Roshangar L (2022a) Kaempferol as a potential neuroprotector in Alzheimer\u2019s disease. J Food Biochem 46:e14375","journal-title":"J Food Biochem"},{"key":"10460_CR37","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15488","volume":"10","author":"HR Nejabati","year":"2022","unstructured":"Nejabati HR, Roshangar L (2022b) Kaempferol: a potential agent in the prevention of colorectal cancer. Physiol Rep 10:e15488","journal-title":"Physiol Rep"},{"key":"10460_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101131","volume":"62","author":"HR Nejabati","year":"2020","unstructured":"Nejabati HR, Schmeisser K, ShahnazI V, Samimifar D, Faridvand Y, Bahrami-ASL Z, Fathi-MAROUFI N, Nikanfar S, Nouri M (2020) N1-methylnicotinamide: an anti-ovarian aging hormetin? Ageing Res Rev 62:101131","journal-title":"Ageing Res Rev"},{"key":"10460_CR39","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.2174\/1381612829666230719121548","volume":"29","author":"HR Nejabati","year":"2023","unstructured":"Nejabati HR, Nikzad S, Roshangar L (2023) Kaempferol: a dietary flavonol in alleviating obesity. Curr Pharm des 29:1547\u20131556","journal-title":"Curr Pharm des"},{"key":"10460_CR40","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.taap.2005.04.004","volume":"209","author":"P Niering","year":"2005","unstructured":"Niering P, Michels G, W\u00e4tjen W, Ohler S, Steffan B, Chovolou Y, Kampk\u00f6tter A, Proksch P, Kahl R (2005) Protective and detrimental effects of kaempferol in rat H4IIE cells: implication of oxidative stress and apoptosis. Toxicol Appl Pharmacol 209:114\u2013122","journal-title":"Toxicol Appl Pharmacol"},{"key":"10460_CR41","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1124\/dmd.30.5.576","volume":"30","author":"Y Otake","year":"2002","unstructured":"Otake Y, Hsieh F, Walle T (2002) Glucuronidation versus oxidation of the flavonoid galangin by human liver microsomes and hepatocytes. Drug Metab Dispos 30:576\u2013581","journal-title":"Drug Metab Dispos"},{"key":"10460_CR42","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1021\/np9904509","volume":"63","author":"PG Pietta","year":"2000","unstructured":"Pietta PG (2000) Flavonoids as antioxidants. J Nat Prod 63:1035\u20131042","journal-title":"J Nat Prod"},{"key":"10460_CR43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087766","volume":"9","author":"L Qiao","year":"2014","unstructured":"Qiao L, Sun Y, Chen R, Fu Y, Zhang W, Li X, Chen J, Shen Y, Ye X (2014) Sonochemical effects on 14 flavonoids common in citrus: relation to stability. PLoS ONE 9:e87766","journal-title":"PLoS ONE"},{"issue":"1","key":"10460_CR44","doi-asserted-by":"publisher","first-page":"8878923","DOI":"10.1155\/2022\/8878923","volume":"2022","author":"Y Qu","year":"2022","unstructured":"Qu Y, Shi L, Liu Y, Huang L, Luo HR, Wu GS (2022) Orientin prolongs the longevity of caenorhabditis elegans and postpones the development of neurodegenerative diseases via nutrition sensing and cellular protective pathways. Oxid Med Cell Longevity 2022(1):8878923","journal-title":"Oxid Med Cell Longevity"},{"issue":"24","key":"10460_CR45","doi-asserted-by":"publisher","first-page":"5376","DOI":"10.3390\/nu14245376","volume":"14","author":"SI Rattan","year":"2022","unstructured":"Rattan SI, Kaur G (2022) Nutrition, food and diet in health and longevity: we eat what we are. Nutrients 14(24):5376","journal-title":"Nutrients"},{"key":"10460_CR46","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.exger.2010.03.014","volume":"45","author":"M Ristow","year":"2010","unstructured":"Ristow M, Zarse K (2010) How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis (mitohormesis). Exp Gerontol 45:410\u2013418","journal-title":"Exp Gerontol"},{"key":"10460_CR47","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/nature12474","volume":"501","author":"JM Ross","year":"2013","unstructured":"Ross JM, Stewart JB, Hagstr\u00f6m E, Bren\u00e9 S, Mourier A, Coppotelli G, Freyer C, Lagouge M, Hoffer BJ, Olson L, Larsson NG (2013) Germline mitochondrial DNA mutations aggravate ageing and can impair brain development. Nature 501:412\u2013415","journal-title":"Nature"},{"key":"10460_CR48","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/mrd.23107","volume":"86","author":"J Santos","year":"2019","unstructured":"Santos J, Lins T, Barberino R, Menezes V, Gouveia B, Matos M (2019) Kaempferol promotes primordial follicle activation through the phosphatidylinositol 3\u2010kinase\/protein kinase B signaling pathway and reduces DNA fragmentation of sheep preantral follicles cultured in vitro. Mol Reprod Dev 86:319\u2013329","journal-title":"Mol Reprod Dev"},{"key":"10460_CR49","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1093\/mutage\/12.5.383","volume":"12","author":"ID Silva","year":"1997","unstructured":"Silva ID, Rodrigues AS, Gaspar J, Maia R, Laires A (1997) Involvement of rat cytochrome 1A1 in the biotransformation of kaempferol to quercetin: relevance to the genotoxicity of kaempferol. Mutagenesis 12:383\u2013390","journal-title":"Mutagenesis"},{"issue":"5","key":"10460_CR50","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s10522-017-9730-8","volume":"18","author":"L Sodagam","year":"2017","unstructured":"Sodagam L, Lewinska A, Wnuk M, Rattan SI (2017) Chronic exposure to rapamycin and episodic serum starvation modulate ageing of human fibroblasts in vitro. Biogerontology 18(5):841\u2013854","journal-title":"Biogerontology"},{"key":"10460_CR51","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3389\/fgene.2019.00081","volume":"10","author":"L Sodagam","year":"2019","unstructured":"Sodagam L, Lewinska A, Kwasniewicz E, Kokhanovska S, Wnuk M, Siems K, Rattan SIS (2019) Phytochemicals rosmarinic acid, ampelopsin, and Amorfrutin-A can modulate age-related phenotype of serially passaged human skin fibroblasts in vitro. Front Genet 10:81","journal-title":"Front Genet"},{"key":"10460_CR52","doi-asserted-by":"publisher","first-page":"373","DOI":"10.3389\/fncel.2014.00373","volume":"8","author":"RM Stilling","year":"2014","unstructured":"Stilling RM, Benito E, Gertig M, Barth J, Capece V, Burkhardt S, Bonn S, Fischer A (2014) De-regulation of gene expression and alternative splicing affects distinct cellular pathways in the aging hippocampus. Front Cell Neurosci 8:373","journal-title":"Front Cell Neurosci"},{"key":"10460_CR53","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1016\/j.phymed.2016.07.015","volume":"23","author":"K Suchal","year":"2016","unstructured":"Suchal K, Malik S, Gamad N, Malhotra RK, Goyal SN, Bhatia J, Arya DS (2016) Kampeferol protects against oxidative stress and apoptotic damage in experimental model of isoproterenol-induced cardiac toxicity in rats. Phytomedicine 23:1401\u20131408","journal-title":"Phytomedicine"},{"issue":"10","key":"10460_CR54","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.3390\/cells8101132","volume":"8","author":"YL Sun","year":"2019","unstructured":"Sun YL, Tang SB, Shen W, Yin S, Sun QY (2019) Roles of resveratrol in improving the quality of postovulatory aging oocytes in vitro. Cells 8(10):1132","journal-title":"Cells"},{"key":"10460_CR55","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/nrm2952","volume":"11","author":"SW Tait","year":"2010","unstructured":"Tait SW, Green DR (2010) Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol 11:621\u2013632","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10460_CR56","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1745-4565.1983.tb00455.x","volume":"5","author":"H Takanashi","year":"1983","unstructured":"Takanashi H, Aiso S, Hirono I, Matsushima T, Sugimura T (1983) Carcinogenicity test of quercetin and kaempferol in rats by oral administration. J Food Saf 5:55\u201360","journal-title":"J Food Saf"},{"key":"10460_CR57","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1093\/molehr\/gaaa040","volume":"26","author":"I Takehara","year":"2020","unstructured":"Takehara I, Igarashi H, Kawagoe J, Matsuo K, Takahashi K, Nishi M, Nagase S (2020) Impact of endoplasmic reticulum stress on oocyte aging mechanisms. Mol Hum Reprod 26:567\u2013575","journal-title":"Mol Hum Reprod"},{"key":"10460_CR58","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1093\/humupd\/dmm048","volume":"14","author":"C Tatone","year":"2008","unstructured":"Tatone C, Amicarelli F, Carbone MC, Monteleone P, Caserta D, Marci R, Artini PG, Piomboni P, Focarelli R (2008) Cellular and molecular aspects of ovarian follicle ageing. Hum Reprod Update 14:131\u2013142","journal-title":"Hum Reprod Update"},{"key":"10460_CR59","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.ijpharm.2008.09.023","volume":"367","author":"XJ Tian","year":"2009","unstructured":"Tian XJ, Yang XW, Yang X, Wang K (2009) Studies of intestinal permeability of 36 flavonoids using Caco-2 cell monolayer model. Int J Pharm 367:58\u201364","journal-title":"Int J Pharm"},{"key":"10460_CR60","doi-asserted-by":"publisher","first-page":"681.7","DOI":"10.1096\/fasebj.31.1_supplement.681.7","volume":"31","author":"F Toussaint","year":"2017","unstructured":"Toussaint F, B\u00e9ziau D, Charbel C, Blanchette A, Mayer G, Comtois P, Ledoux J (2017) Endothelial mitochondria regulate local calcium signalling in mesenteric arteries from mice. FASEB J 31:681.7-681.7","journal-title":"FASEB J"},{"key":"10460_CR61","first-page":"77","volume":"12","author":"AE Treloar","year":"1967","unstructured":"Treloar AE, Boynton RE, Behn BG, Brown BW (1967) Variation of the human menstrual cycle through reproductive life. Int J Fertil 12:77\u2013126","journal-title":"Int J Fertil"},{"key":"10460_CR62","doi-asserted-by":"publisher","first-page":"424","DOI":"10.3389\/fphar.2020.00424","volume":"11","author":"J Wang","year":"2020","unstructured":"Wang J, Mao J, Wang R, Li S, Wu B, Yuan Y (2020) Kaempferol protects against cerebral ischemia reperfusion injury through intervening oxidative and inflammatory stress induced apoptosis. Front Pharmacol 11:424","journal-title":"Front Pharmacol"},{"key":"10460_CR63","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1186\/s12885-021-08158-z","volume":"21","author":"F Wang","year":"2021","unstructured":"Wang F, Wang L, Qu C, Chen L, Geng Y, Cheng C, Yu S, Wang D, Yang L, Meng Z, Chen Z (2021) Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt\/mTOR signaling. BMC Cancer 21:396","journal-title":"BMC Cancer"},{"key":"10460_CR64","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.cell.2016.02.032","volume":"165","author":"MD White","year":"2016","unstructured":"White MD, Angiolini JF, Alvarez YD, Kaur G, Zhao ZW, Mocskos E, Bruno L, Bissiere S, Levi V, Plachta N (2016) Long-lived binding of Sox2 to DNA predicts cell fate in the four-cell mouse embryo. Cell 165:75\u201387","journal-title":"Cell"},{"issue":"16","key":"10460_CR65","doi-asserted-by":"publisher","first-page":"3578","DOI":"10.3390\/nu15163578","volume":"15","author":"M Wici\u0144ski","year":"2023","unstructured":"Wici\u0144ski M, Erdmann J, Nowacka A, Ku\u017ami\u0144ski O, Michalak K, Janowski K, Ohla J, Biernaciak A, Szambelan M, Zabrzy\u0144ski J (2023) Natural phytochemicals as SIRT activators\u2014focus on potential biochemical mechanisms. Nutrients 15(16):3578","journal-title":"Nutrients"},{"key":"10460_CR66","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1080\/09637486.2016.1276518","volume":"68","author":"D Xiang","year":"2017","unstructured":"Xiang D, Wang CG, Wang WQ, Shi CY, Xiong W, Wang MD, Fang JG (2017) Gastrointestinal stability of dihydromyricetin, myricetin, and myricitrin: an in vitro investigation. Int J Food Sci Nutr 68:704\u2013711","journal-title":"Int J Food Sci Nutr"},{"key":"10460_CR67","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.biotechadv.2014.04.006","volume":"32","author":"J Xiao","year":"2014","unstructured":"Xiao J, Muzashvili TS, Georgiev MI (2014) Advances in the biotechnological glycosylation of valuable flavonoids. Biotechnol Adv 32:1145\u20131156","journal-title":"Biotechnol Adv"},{"issue":"1","key":"10460_CR68","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1039\/D2FO02688K","volume":"14","author":"W Xu","year":"2023","unstructured":"Xu W, Luo Y, Yin J, Huang M, Luo F (2023) Targeting AMPK signaling by polyphenols: a novel strategy for tackling aging. Food Funct 14(1):56\u201373","journal-title":"Food Funct"},{"key":"10460_CR69","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1093\/biolre\/iox178","volume":"98","author":"R Yang","year":"2018","unstructured":"Yang R, Sun HH, Ji CL, Zhang J, Yuan HJ, Luo MJ, Liu XY, Tan JH (2018) Role of calcium-sensing receptor in regulating spontaneous activation of postovulatory aging rat oocytes. Biol Reprod 98:218\u2013226","journal-title":"Biol Reprod"},{"key":"10460_CR70","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1080\/10408398.2021.1980762","volume":"63","author":"L Yang","year":"2023","unstructured":"Yang L, Gao Y, Bajpai VK, El-KammaR HA, Simal-Gandara J (2023) Advance toward isolation, extraction, metabolism and health benefits of kaempferol, a major dietary flavonoid with future perspectives. Crit Rev Food Sci Nutri 63:2773\u20132789","journal-title":"Crit Rev Food Sci Nutri"},{"key":"10460_CR71","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1111\/asj.13280","volume":"90","author":"X Yao","year":"2019","unstructured":"Yao X, Jiang H, Li YH, Gao Q, Xu YN, Kim NH (2019) Kaempferol alleviates the reduction of developmental competence during aging of porcine oocytes. Anim Sci J 90:1417\u20131425","journal-title":"Anim Sci J"},{"issue":"11","key":"10460_CR72","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1111\/asj.13280","volume":"90","author":"X Yao","year":"2019","unstructured":"Yao X, Jiang H, Li YH, Gao Q, Xu YN, Kim NH (2019) Kaempferol alleviates the reduction of developmental competence during aging of porcine oocytes. Animal Sci J 90(11):1417\u20131425","journal-title":"Animal Sci J"},{"key":"10460_CR73","doi-asserted-by":"publisher","first-page":"971","DOI":"10.3892\/ijmm.2013.1468","volume":"32","author":"HY Yoon","year":"2013","unstructured":"Yoon HY, Lee EG, Lee H, Cho IJ, Choi YJ, Sung MS, Yoo HG, Yoo WH (2013) Kaempferol inhibits IL-1\u03b2-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COX-2, PGE2 and MMPs. Int J Mol Med 32:971\u2013977","journal-title":"Int J Mol Med"},{"key":"10460_CR74","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.rbmo.2022.07.005","volume":"45","author":"Z-C Zeng","year":"2022","unstructured":"Zeng Z-C, Jiang J, Wang X-J, Wei K-N, Liang H-S, Zeng L-X, Xu Y, Xie S-J, Meng Z, Yang X-J, GuO A-W, Wang H-L (2022) Kaempferol ameliorates in-vitro and in-vivo postovulatory oocyte ageing in mice. Reprod Biomed Online 45:1065\u20131083","journal-title":"Reprod Biomed Online"},{"key":"10460_CR75","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.ejphar.2011.08.011","volume":"670","author":"Y Zhang","year":"2011","unstructured":"Zhang Y, Liu D (2011) Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function. Eur J Pharmacol 670:325\u2013332","journal-title":"Eur J Pharmacol"},{"key":"10460_CR76","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s11010-022-04546-6","volume":"478","author":"Q Zhang","year":"2023","unstructured":"Zhang Q, Chen L, Gao M, Wang S, Meng L, Guo L (2023) Molecular docking and in vitro experiments verified that kaempferol induced apoptosis and inhibited human HepG2 cell proliferation by targeting BAX, CDK1, and JUN. Mol Cell Biochem 478:767\u2013780","journal-title":"Mol Cell Biochem"},{"key":"10460_CR77","doi-asserted-by":"publisher","first-page":"795","DOI":"10.3390\/app9040795","volume":"9","author":"C Zhao","year":"2019","unstructured":"Zhao C, Ren X, Li C, Jiang H, Guan J, Su W, Li Y, Tian Y, Wang T, Li S (2019) Coupling ultrasound with heat-reflux to improve the extraction of quercetin, kaempferol, ginkgetin and sciadopitysin from Mairei Yew leaves. Appl Sci 9:795","journal-title":"Appl Sci"},{"key":"10460_CR78","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134633","volume":"716","author":"L Zhao","year":"2020","unstructured":"Zhao L, Sun J, Shi S, Qin X, Zhang K, Xu J (2020) Kaempferol protects retinal ganglion ceils from high-glucose-induced injury by regulating vasohibin-1. Neurosci Lett 716:134633","journal-title":"Neurosci Lett"},{"key":"10460_CR79","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/481405","volume":"2015","author":"M Zhou","year":"2015","unstructured":"Zhou M, Ren H, Han J, Wang W, Zheng Q, Wang D (2015) Protective effects of kaempferol against myocardial ischemia\/reperfusion injury in isolated rat heart via antioxidant activity and inhibition of glycogen synthase kinase-3\u03b2. Oxid Med Cell Longev 2015:481405","journal-title":"Oxid Med Cell Longev"}],"container-title":["Biogerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-026-10460-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10522-026-10460-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-026-10460-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:02:29Z","timestamp":1789045349000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10522-026-10460-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":79,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10460"],"URL":"https:\/\/doi.org\/10.1007\/s10522-026-10460-x","relation":{},"ISSN":["1389-5729","1573-6768"],"issn-type":[{"value":"1389-5729","type":"print"},{"value":"1573-6768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"assertion":[{"value":"18 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflicts of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"112"}}