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Nutritional interventions have emerged as a potential strategy to maintain health with age. Testing these interventions for effects on human ageing would take several years and require large cohort sizes. We therefore employed\n                    <jats:italic>C. elegans<\/jats:italic>\n                    \u00a0as a rapidly ageing model organism to investigate the effects of two commercially available nutrition-based products on ageing-related decline of mobility as an indication of healthspan. These products are multi-ingredient formulations comprising vitamins, minerals, antioxidants, amino acids and botanical extracts. They include compounds expected to positively influence ageing such as Dihydronicotinamide mononucleotide, NAD\u2009+\u2009booster, trans-resveratrol, taurine, pterostilbene and bioflavonoids. V14\u2122 contains 40\u2009+\u2009ingredients and AG1\u00ae contains 70\u2009+\u2009ingredients with 5 additional probiotic strains. Mobility-based readouts over time were obtained using WormGazer\u2122 imaging technology. Worms exposed to V14\u2122 showed increased movement and speed with age compared to those exposed to AG1\u00ae and to a solvent control. To investigate the underlying mechanisms, transcriptomic profiling was performed on V14\u2122 exposed worms, revealing modulation of pathways involved in metabolism and stress responses, processes associated with ageing. Collectively, these findings suggest that V14\u2122 delays age-related decline in\n                    <jats:italic>C. elegans<\/jats:italic>\n                    \u00a0and highlight the potential of targeted nutritional interventions to modulate pathways relevant to human ageing.\n                  <\/jats:p>","DOI":"10.1007\/s10522-026-10463-8","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T02:42:09Z","timestamp":1782614529000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A multi-ingredient food supplement slows age-dependent decline of mobility and influences gene expression in C. elegans"],"prefix":"10.1007","volume":"27","author":[{"given":"Chad","family":"Yanyatan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Mohanraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fasseas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushmita","family":"Maitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"Van Harmelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Saunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7399-1202","authenticated-orcid":false,"given":"David","family":"Weinkove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"issue":"3","key":"10463_CR1","doi-asserted-by":"publisher","first-page":"E277","DOI":"10.1073\/PNAS.1412192112","volume":"112","author":"A Bansal","year":"2015","unstructured":"Bansal A, Zhu LJ, Yen K, Tissenbaum HA (2015) Uncoupling lifespan and healthspan in caenorhabditis elegans longevity mutants. 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Author E. V. H. is the founder of Youth and Earth. Author D. W. and C. S. are cofounders at Magnitude Biosciences Ltd. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"120"}}