{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:47:05Z","timestamp":1792000025477,"version":"4.4.0"},"reference-count":151,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biogerontology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10522-026-10526-w","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:02:15Z","timestamp":1791954135000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hippo\u2013YAP\/TAZ signalling at the crossroads of brain ageing and neurological disorders: mechanisms, crosstalk, and therapeutic prospects"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5272-9907","authenticated-orcid":false,"given":"Bhaskar Jyoti","family":"Dutta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal Shivaji","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanket","family":"Seksaria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shradha","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Basak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"10526_CR1","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202209120","volume":"222","author":"JF Abenza","year":"2023","unstructured":"Abenza JF, Rossetti L, Mouelhi M, Burgu\u00e9s J, Andreu I, Kennedy K, Roca-Cusachs P, Marco S, Garc\u00eda-Ojalvo J, Trepat X (2023) Mechanical control of the mammalian circadian clock via YAP\/TAZ and TEAD. J Cell Biol 222:e202209120","journal-title":"J Cell Biol"},{"key":"10526_CR2","volume":"7","author":"N Abou Nader","year":"2023","unstructured":"Abou Nader N, Blais \u00c9, St-Jean G, Boerboom D, Zamberlam G, Boyer A (2023) Effect of inactivation of Mst1 and Mst2 in the mouse adrenal cortex. J Endocr Soc 7:bvac143","journal-title":"J Endocr Soc"},{"key":"10526_CR3","doi-asserted-by":"crossref","first-page":"24503","DOI":"10.1073\/pnas.2004087117","volume":"117","author":"EH Ahn","year":"2020","unstructured":"Ahn EH, Kang SS, Qi Q, Liu X, Ye K (2020) Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson\u2019s disease. Proc Natl Acad Sci 117:24503\u201324513","journal-title":"Proc Natl Acad Sci"},{"key":"10526_CR4","doi-asserted-by":"crossref","first-page":"1522705","DOI":"10.3389\/fcell.2025.1522705","volume":"13","author":"AOO Ajongbolo","year":"2025","unstructured":"Ajongbolo AOO, Langhans SAA (2025) YAP\/TAZ-associated cell signaling \u2013 at the crossroads of cancer and neurodevelopmental disorders. Frontiers Cell Dev Biol 13:1522705","journal-title":"Frontiers Cell Dev Biol"},{"key":"10526_CR5","doi-asserted-by":"crossref","DOI":"10.3390\/cells13221868","volume":"13","author":"B Amanda","year":"2024","unstructured":"Amanda B, Pragasta R, Cakrasana H, Mustika A, Faizah Z, Oceandy D (2024) The hippo signaling pathway, reactive oxygen species production, and oxidative stress: a two-way traffic regulation. Cells 13:1868","journal-title":"Cells"},{"key":"10526_CR6","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S1474-4422(16)30230-7","volume":"15","author":"A Ascherio","year":"2016","unstructured":"Ascherio A, Schwarzschild MA (2016) The epidemiology of Parkinson\u2019s disease: risk factors and prevention. Lancet Neurol 15:1257\u20131272","journal-title":"Lancet Neurol"},{"key":"10526_CR7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cell.2014.06.013","volume":"158","author":"L Azzolin","year":"2014","unstructured":"Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, Bresolin S, Frasson C, Basso G, Guzzardo V, Fassina A, Cordenonsi M, Piccolo S (2014) YAP\/TAZ incorporation in the \u03b2-catenin destruction complex orchestrates the Wnt response. Cell 158:157\u2013170","journal-title":"Cell"},{"key":"10526_CR8","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neulet.2009.04.050","volume":"458","author":"TC Bates","year":"2009","unstructured":"Bates TC, Price JF, Harris SE, Marioni RE, Fowkes FG, Stewart MC, Murray GD, Whalley LJ, Starr JM, Deary IJ (2009) Association of KIBRA and memory. Neurosci Lett 458:140\u2013143","journal-title":"Neurosci Lett"},{"key":"10526_CR9","doi-asserted-by":"crossref","DOI":"10.3390\/biom14091186","volume":"14","author":"A Berdiaki","year":"2024","unstructured":"Berdiaki A, Neagu M, Tzanakakis P, Spyridaki I, P\u00e9rez S, Nikitovic D (2024) Extracellular matrix components and mechanosensing pathways in health and disease. Biomolecules 14:1186","journal-title":"Biomolecules"},{"issue":"11","key":"10526_CR10","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/psp4.12852","volume":"11","author":"P Bloomingdale","year":"2022","unstructured":"Bloomingdale P, Karelina T, Ramakrishnan V, Bakshi S, V\u00e9ronneau-Veilleux F, Moye M, Sekiguchi K, Meno-Tetang G, Mohan A, Maithreye R (2022) Hallmarks of neurodegenerative disease: a systems pharmacology perspective. CPT Pharmacometrics Syst Pharmacol 11(11):1399\u20131429","journal-title":"CPT Pharmacometrics Syst Pharmacol"},{"key":"10526_CR11","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191561","author":"C Bonnard","year":"2020","unstructured":"Bonnard C, Navaratnam N, Ghosh K, Chan PW, Tan TT, Pomp O, Ng AYJ, Tohari S, Changede R, Carling D, Venkatesh B, Altunoglu U, Kayserili H, Reversade B (2020) A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling. J Exp Med. https:\/\/doi.org\/10.1084\/jem.20191561","journal-title":"J Exp Med"},{"key":"10526_CR12","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1016\/j.febslet.2009.09.002","volume":"583","author":"Q Cai","year":"2009","unstructured":"Cai Q, Wang W, Gao Y, Yang Y, Zhu Z, Fan Q (2009) Ce-wts-1 plays important roles in Caenorhabditis elegans development. FEBS Lett 583:3158\u20133164","journal-title":"FEBS Lett"},{"key":"10526_CR13","volume":"2","author":"X Cao","year":"2023","unstructured":"Cao X, Wang W, Zhao B (2023) YAP\/TAZ links mechanosensing to aging. Life Med 2:lnac039","journal-title":"Life Med"},{"key":"10526_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2025.115630","author":"X Chen","year":"2025","unstructured":"Chen X, Yao H, Ma S, Zhu H, Xu Y, Zhu Y, Ying Y, Wang L, Zhang Q, Zheng C (2025a) FGF22\/FGFR2\/YAP modulates ferroptosis to suppress neurodegeneration and cognitive impairment in Alzheimer\u2019s disease. Exp Neurol. https:\/\/doi.org\/10.1016\/j.expneurol.2025.115630","journal-title":"Exp Neurol"},{"key":"10526_CR15","volume":"20","author":"D Chen","year":"2025","unstructured":"Chen D, Wigglesworth-Littlewood S, Gunn-Moore FJ (2025b) The Hippo signaling pathway as a therapeutic target in Alzheimer\u2019s disease. Mol Neurodegener 20:100","journal-title":"Mol Neurodegener"},{"key":"10526_CR16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3389\/fimmu.2020.00281","volume":"11","author":"J Cheng","year":"2020","unstructured":"Cheng J, Wang S, Dong Y, Yuan Z (2020) The role and regulatory mechanism of Hippo signaling components in the neuronal system. Front Immunol 11:281","journal-title":"Front Immunol"},{"key":"10526_CR17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1101\/gad.333146.119","volume":"34","author":"YS Cho","year":"2020","unstructured":"Cho YS, Li S, Wang X, Zhu J, Zhuo S, Han Y, Yue T, Yang Y, Jiang J (2020) CDK7 regulates organ size and tumor growth by safeguarding the Hippo pathway effector Yki\/Yap\/Taz in the nucleus. Genes Dev 34:53\u201371","journal-title":"Genes Dev"},{"key":"10526_CR18","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s13770-024-00635-3","volume":"21","author":"J Choi","year":"2024","unstructured":"Choi J, Park SW, Lee H, Kim DH, Kim SW (2024) Human nasal inferior turbinate-derived neural stem cells improve the niche of substantia nigra par compacta in a Parkinson\u2019s disease model by modulating Hippo signaling. Tissue Eng Regen Med 21:737\u2013748","journal-title":"Tissue Eng Regen Med"},{"key":"10526_CR19","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2174\/1874609816666230206144212","volume":"16","author":"A Christoper","year":"2023","unstructured":"Christoper A, Herman H, Abdulah R, Zulhendri F, Sanjaya A, Lesmana R (2023) Physiological roles of Hippo signaling pathway and autophagy in dementia. Curr Aging Sci 16:112\u2013124","journal-title":"Curr Aging Sci"},{"key":"10526_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43775-1","volume":"14","author":"A Claude-Taupin","year":"2023","unstructured":"Claude-Taupin A, Isnard P, Bagattin A, Kuperwasser N, Roccio F, Ruscica B, Goudin N, Garfa-Traor\u00e9 M, Regnier A, Turinsky L (2023) The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells. Nat Commun 14:8056","journal-title":"Nat Commun"},{"key":"10526_CR21","first-page":"485","volume":"9","author":"L Cuollo","year":"2020","unstructured":"Cuollo L, Antonangeli F, Santoni A, Soriani A (2020) The senescence-associated secretory phenotype (SASP) in the challenging future of cancer therapy and age-related diseases. Biology (Basel) 9:485","journal-title":"Biology (Basel)"},{"key":"10526_CR22","doi-asserted-by":"crossref","first-page":"468","DOI":"10.14336\/AD.2023.0321-1","volume":"14","author":"S Deng","year":"2023","unstructured":"Deng S, Gan L, Liu C, Xu T, Zhou S, Guo Y, Zhang Z, Yang GY, Tian H, Tang Y (2023) Roles of ependymal cells in the physiology and pathology of the central nervous system. Aging Dis 14:468\u2013483","journal-title":"Aging Dis"},{"key":"10526_CR23","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/15548627.2022.2063004","volume":"19","author":"E Desideri","year":"2023","unstructured":"Desideri E, Castelli S, Dorard C, Toifl S, Grazi GL, Ciriolo MR, Baccarini M (2023) Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells. Autophagy 19:152\u2013162","journal-title":"Autophagy"},{"key":"10526_CR24","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1093\/hmg\/ddad115","volume":"32","author":"L Dong","year":"2023","unstructured":"Dong L, Gao L (2023) JMJD3 and SNAI2 synergistically protect against Parkinson\u2019s disease by mediating the YAP\/HIF1\u03b1 signaling pathway in a mouse model. Hum Mol Genet 32:3040\u20133052","journal-title":"Hum Mol Genet"},{"key":"10526_CR25","doi-asserted-by":"crossref","DOI":"10.1186\/s13024-025-00842-z","volume":"20","author":"N Donison","year":"2025","unstructured":"Donison N, Palik J, Volkening K, Strong MJ (2025) Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for chronic traumatic encephalopathy. Mol Neurodegener 20:56","journal-title":"Mol Neurodegener"},{"key":"10526_CR26","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/s41580-023-00644-5","volume":"24","author":"JH Driskill","year":"2023","unstructured":"Driskill JH, Pan D (2023) Control of stem cell renewal and fate by YAP and TAZ. Nat Rev Mol Cell Biol 24:895\u2013911","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10526_CR27","doi-asserted-by":"crossref","first-page":"C52","DOI":"10.1152\/ajpcell.00122.2023","volume":"325","author":"M Dudek","year":"2023","unstructured":"Dudek M, Swift J, Meng Q-J (2023) The circadian clock and extracellular matrix homeostasis in aging and age-related diseases. Am J Physiol Cell Physiol 325:C52\u2013C59","journal-title":"Am J Physiol Cell Physiol"},{"key":"10526_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16167-y","volume":"11","author":"N Eder","year":"2020","unstructured":"Eder N, Roncaroli F, Domart M-C, Horswell S, Andreiuolo F, Flynn HR, Lopes AT, Claxton S, Kilday J-P, Collinson L, Mao J-H, Pietsch T, Thompson B, Snijders AP, Ultanir SK (2020) YAP1\/TAZ drives ependymoma-like tumour formation in mice. Nat Commun 11:2380","journal-title":"Nat Commun"},{"key":"10526_CR29","doi-asserted-by":"crossref","DOI":"10.1111\/acel.70218","volume":"24","author":"RC Evans","year":"2025","unstructured":"Evans RC, Dar NJ, Chen L, Na R, O\u2019Connor JC, Jiang J, Zheng S, Ran Q (2025) Inhibition of Hippo signaling through ablation of Lats1 and Lats2 protects against cognitive decline in 5xFAD mice via increasing neuronal resilience against ferroptosis. Aging Cell 24:e70218","journal-title":"Aging Cell"},{"key":"10526_CR30","volume":"43","author":"X Fang","year":"2025","unstructured":"Fang X, Jia H, Pan S, Liu Q, Wang Q, Feng Y, Ding W, Luo T (2025) Matrix stiffness regulates interleukin-10 secretion in human microglia (HMC3) via YAP-mediated mechanotransduction. Cell Biochem Funct 43:e70061","journal-title":"Cell Biochem Funct"},{"key":"10526_CR31","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1101\/gad.1824509","volume":"23","author":"LA Fernandez","year":"2009","unstructured":"Fernandez LA, Northcott PA, Dalton J, Fraga C, Ellison D, Angers S, Taylor MD, Kenney AM (2009) YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev 23:2729\u20132741","journal-title":"Genes Dev"},{"key":"10526_CR32","volume":"7","author":"M Fu","year":"2022","unstructured":"Fu M, Hu Y, Lan T, Guan KL, Luo T, Luo M (2022) The Hippo signalling pathway and its implications in human health and diseases. Signal Transduct Target Ther 7:376","journal-title":"Signal Transduct Target Ther"},{"key":"10526_CR33","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1248\/bpbreports.6.4_144","volume":"6","author":"H Fujimori","year":"2023","unstructured":"Fujimori H, Ohba T, Nakamura S, Shimazawa Y, Takahashi D, Iwawaki T, Kamon J, Shimazawa M, Hara H (2023) LATS inhibitor protects 6-OHDA induced neuronal cell death in vitro and in vivo. BPB Rep 6:144\u2013149","journal-title":"BPB Rep"},{"key":"10526_CR34","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1089\/neu.2022.0041","volume":"40","author":"RC Gardner","year":"2023","unstructured":"Gardner RC, Bahorik A, Kornblith ES, Allen IE, Plassman BL, Yaffe K (2023) Systematic review, meta-analysis, and population attributable risk of dementia associated with traumatic brain injury in civilians and veterans. J Neurotrauma 40:620\u2013634","journal-title":"J Neurotrauma"},{"key":"10526_CR35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbr.2018.08.003","volume":"356","author":"P Gong","year":"2019","unstructured":"Gong P, Zhang Z, Zou C, Tian Q, Chen X, Hong M, Liu X, Chen Q, Xu Z, Li M (2019) Hippo\/YAP signaling pathway mitigates blood-brain barrier disruption after cerebral ischemia\/reperfusion injury. Behav Brain Res 356:8\u201317","journal-title":"Behav Brain Res"},{"key":"10526_CR36","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.brainresbull.2021.10.017","volume":"177","author":"P Gong","year":"2021","unstructured":"Gong P, Zou Y, Zhang W, Tian Q, Han S, Xu Z, Chen Q, Wang X, Li M (2021a) The neuroprotective effects of insulin-like growth factor 1 via the Hippo\/YAP signaling pathway are mediated by the PI3K\/AKT cascade following cerebral ischemia\/reperfusion injury. Brain Res Bull 177:373\u2013387","journal-title":"Brain Res Bull"},{"key":"10526_CR37","volume":"12","author":"S Gong","year":"2021","unstructured":"Gong S, Ma H, Zheng F, Huang J, Zhang Y, Yu B, Li F, Kou J (2021b) Inhibiting YAP in endothelial cells from entering the nucleus attenuates blood-brain barrier damage during ischemia-reperfusion injury. Front Pharmacol 12:777680","journal-title":"Front Pharmacol"},{"key":"10526_CR38","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.040079","volume":"15","author":"R G\u00f6ttert","year":"2026","unstructured":"G\u00f6ttert R, Kikhia M, Herzog ML, Pan W, Klaus\u2010Bergmann A, Weiner J 3rd, Beule D, Knauss S, Kronenberg G, Potente M (2026) Loss of endothelial YAP\/TAZ reduces the size of chronic stroke lesions and alters the endothelial environment. J Am Heart Assoc 15:e040079","journal-title":"J Am Heart Assoc"},{"key":"10526_CR39","unstructured":"Greco F, (2025) ARID1A supports the expression of YAP target genes by facilitating the binding of TEAD on enhancers in epithelial breast cells."},{"key":"10526_CR40","volume":"8","author":"BC Heng","year":"2020","unstructured":"Heng BC, Zhang X, Aubel D, Bai Y, Li X, Wei Y, Fussenegger M, Deng X (2020) Role of YAP\/TAZ in cell lineage fate determination and related signaling pathways. Front Cell Dev Biol 8:735","journal-title":"Front Cell Dev Biol"},{"key":"10526_CR41","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s00018-020-03579-8","volume":"78","author":"BC Heng","year":"2021","unstructured":"Heng BC, Zhang X, Aubel D, Bai Y, Li X, Wei Y, Fussenegger M, Deng X (2021) An overview of signaling pathways regulating YAP\/TAZ activity. Cell Mol Life Sci 78:497\u2013512","journal-title":"Cell Mol Life Sci"},{"key":"10526_CR42","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41580-019-0101-y","volume":"20","author":"MS Hipp","year":"2019","unstructured":"Hipp MS, Kasturi P, Hartl FU (2019) The proteostasis network and its decline in ageing. Nat Rev Mol Cell Biol 20:421\u2013435","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10526_CR43","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/dgd.12867","volume":"65","author":"D Honda","year":"2023","unstructured":"Honda D, Okumura M, Chihara T (2023) Crosstalk between the mTOR and Hippo pathways. Dev Growth Differ 65:337\u2013347","journal-title":"Dev Growth Differ"},{"key":"10526_CR44","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2174\/1871527318666191021144126","volume":"18","author":"G Hong","year":"2019","unstructured":"Hong G, Yan Y, Zhong Y, Chen J, Tong F, Ma Q (2019) Combined ischemic preconditioning and resveratrol improved blood-brain barrier breakdown via hippo\/YAP\/TAZ signaling pathway. CNS Neurol Disord Drug Targets 18:713\u2013722","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10526_CR45","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1083\/jcb.200509132","volume":"172","author":"M Hoshino","year":"2006","unstructured":"Hoshino M, Qi ML, Yoshimura N, Miyashita T, Tagawa K, Wada Y, Enokido Y, Marubuchi S, Harjes P, Arai N, Oyanagi K, Blandino G, Sudol M, Rich T, Kanazawa I, Wanker EE, Saitoe M, Okazawa H (2006) Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73. J Cell Biol 172:589\u2013604","journal-title":"J Cell Biol"},{"key":"10526_CR46","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41427-021-00304-0","volume":"13","author":"Y Hu","year":"2021","unstructured":"Hu Y, Huang G, Tian J, Qiu J, Jia Y, Feng D, Wei Z, Li S, Xu F (2021) Matrix stiffness changes affect astrocyte phenotype in an in vitro injury model. NPG Asia Mater 13:35","journal-title":"NPG Asia Mater"},{"key":"10526_CR47","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s11427-025-3130-4","volume":"69","author":"J Hu","year":"2026","unstructured":"Hu J, He Z, Hu H, Sun X, Che S, Sun S, Ma M, Zhang Y, Ma S, Zhang W (2026) Mechanosensor YAP orchestrates human neural rosette morphogenesis via TEAD4-LEF1 transcriptional nexus. Sci China Life Sci 69:419\u2013437","journal-title":"Sci China Life Sci"},{"key":"10526_CR48","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cell.2005.06.007","volume":"122","author":"J Huang","year":"2005","unstructured":"Huang J, Wu S, Barrera J, Matthews K, Pan D (2005) The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP. Cell 122:421\u2013434","journal-title":"Cell"},{"key":"10526_CR49","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1242\/dev.130658","volume":"143","author":"Z Huang","year":"2016","unstructured":"Huang Z, Hu J, Pan J, Wang Y, Hu G, Zhou J, Mei L, Xiong WC (2016) YAP stabilizes SMAD1 and promotes BMP2-induced neocortical astrocytic differentiation. Development 143:2398\u20132409","journal-title":"Development"},{"key":"10526_CR50","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ydbio.2019.10.002","volume":"457","author":"LJ Hughes","year":"2020","unstructured":"Hughes LJ, Park R, Lee MJ, Terry BK, Lee DJ, Kim H, Cho S-H, Kim S (2020) Yap\/Taz are required for establishing the cerebellar radial glia scaffold and proper foliation. Dev Biol 457:150\u2013162","journal-title":"Dev Biol"},{"key":"10526_CR51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s41232-025-00372-7","volume":"45","author":"K Irisa","year":"2025","unstructured":"Irisa K, Shichita T (2025) Neural repair mechanisms after ischemic stroke. Inflamm Regen 45:7","journal-title":"Inflamm Regen"},{"key":"10526_CR52","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1007\/s12035-026-05760-9","volume":"63","author":"A Jindal","year":"2026","unstructured":"Jindal A, Rai SN (2026) Targeting autophagy, ferroptosis, and neuroinflammation: polyphenol-mediated modulation of emerging signaling pathways in neurodegeneration. Mol Neurobiol 63:470","journal-title":"Mol Neurobiol"},{"key":"10526_CR53","doi-asserted-by":"publisher","DOI":"10.1101\/2025.10.01.677488","author":"S Joppe","year":"2025","unstructured":"Joppe S, Chevreau R, Abou-Chaaya J, Garcia L, Hansberg Pastor V, Hideg S, Ripoll C, Ghazale H, Nouhaud A, Lalli E (2025) Hippo\/YAP1 Signaling Regulates the oligodendrocyte\u2013astrocyte fate switch and ependymal gene expression in adult spinal cord stem cells. bioRxiv. https:\/\/doi.org\/10.1101\/2025.10.01.677488","journal-title":"bioRxiv"},{"key":"10526_CR54","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/dvg.20330","volume":"45","author":"KJ Kaneko","year":"2007","unstructured":"Kaneko KJ, Kohn MJ, Liu C, DePamphilis ML (2007) Transcription factor TEAD2 is involved in neural tube closure. Genesis 45:577\u2013587","journal-title":"Genesis"},{"key":"10526_CR55","doi-asserted-by":"crossref","first-page":"14218","DOI":"10.1523\/JNEUROSCI.3292-11.2011","volume":"31","author":"K Kauppi","year":"2011","unstructured":"Kauppi K, Nilsson LG, Adolfsson R, Eriksson E, Nyberg L (2011) KIBRA polymorphism is related to enhanced memory and elevated hippocampal processing. J Neurosci 31:14218\u201314222","journal-title":"J Neurosci"},{"key":"10526_CR56","doi-asserted-by":"crossref","DOI":"10.1002\/jnr.70046","volume":"103","author":"S Kelliny","year":"2025","unstructured":"Kelliny S, Zhou XF, Bobrovskaya L (2025) Alzheimer\u2019s disease and frontotemporal dementia: a review of pathophysiology and therapeutic approaches. J Neurosci Res 103:e70046","journal-title":"J Neurosci Res"},{"key":"10526_CR57","doi-asserted-by":"crossref","first-page":"135","DOI":"10.5021\/ad.23.156","volume":"36","author":"JY Kim","year":"2024","unstructured":"Kim JY, Quan T (2024) Emerging perspectives of YAP\/TAZ in human skin epidermal and dermal aging. Ann Dermatol 36:135","journal-title":"Ann Dermatol"},{"key":"10526_CR58","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1172\/JCI93825","volume":"127","author":"J Kim","year":"2017","unstructured":"Kim J, Kim YH, Kim J, Park DY, Bae H, Lee D-H, Kim KH, Hong SP, Jang SP, Kubota Y (2017a) YAP\/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest 127:3441\u20133461","journal-title":"J Clin Invest"},{"key":"10526_CR59","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1073\/pnas.1620306114","volume":"114","author":"Y Kim","year":"2017","unstructured":"Kim Y, Kim W, Song Y, Kim J-R, Cho K, Moon H, Ro SW, Seo E, Ryu Y-M, Myung S-J (2017b) Deubiquitinase YOD1 potentiates YAP\/TAZ activities through enhancing ITCH stability. Proc Natl Acad Sci U S A 114:4691\u20134696","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10526_CR60","doi-asserted-by":"crossref","first-page":"5798","DOI":"10.1111\/febs.16091","volume":"289","author":"H Kwon","year":"2022","unstructured":"Kwon H, Kim J, Jho E (2022) Role of the Hippo pathway and mechanisms for controlling cellular localization of YAP\/TAZ. FEBS J 289:5798\u20135818","journal-title":"FEBS J"},{"key":"10526_CR61","volume":"74","author":"TW Kwon","year":"2026","unstructured":"Kwon TW, Ha Y, Jo HS, Cho IH (2026) Regional and cell\u2010type\u2010specific activation of YAP\/TAZ underlies glial responses in LPS\u2010induced neuroinflammation. Glia 74:e70129","journal-title":"Glia"},{"key":"10526_CR62","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ydbio.2021.08.010","volume":"480","author":"A Lavado","year":"2021","unstructured":"Lavado A, Gangwar R, Par\u00e9 J, Wan S, Fan Y, Cao X (2021) YAP\/TAZ maintain the proliferative capacity and structural organization of radial glial cells during brain development. Dev Biol 480:39\u201349","journal-title":"Dev Biol"},{"key":"10526_CR63","volume":"17","author":"M Law","year":"2024","unstructured":"Law M, Wang P-C, Zhou Z-Y, Wang Y (2024) From microcirculation to aging-related diseases: a focus on endothelial SIRT1. Pharmaceuticals (Basel) 17:1495","journal-title":"Pharmaceuticals (Basel)"},{"key":"10526_CR64","doi-asserted-by":"crossref","first-page":"763","DOI":"10.14348\/molcells.2022.0097","volume":"45","author":"H Lee","year":"2022","unstructured":"Lee H, Lee S-JV (2022) Recent progress in regulation of aging by insulin\/IGF-1 signaling in Caenorhabditis elegans. Mol Cells 45:763\u2013770","journal-title":"Mol Cells"},{"key":"10526_CR65","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-53601-x","volume":"15","author":"Y Lei","year":"2024","unstructured":"Lei Y, Liu Q, Chen B, Wu F, Li Y, Dong X, Ma N, Wu Z, Zhu Y, Wang L (2024) Protein O-GlcNAcylation coupled to Hippo signaling drives vascular dysfunction in diabetic retinopathy. Nat Commun 15:9334","journal-title":"Nat Commun"},{"issue":"1","key":"10526_CR66","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s40035-025-00487-4","volume":"14","author":"L Lei","year":"2025","unstructured":"Lei L, Cheng Y, Yin A, Han J-M, Wu G, Yang F, Wang Q, Wang J-Z, Liu R, Li H-L (2025) Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT\/GSK-3\u03b2 axis. Transl Neurodegener 14:29","journal-title":"Transl Neurodegener"},{"key":"10526_CR67","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/cns.12833","volume":"24","author":"D Li","year":"2018","unstructured":"Li D, Ji JX, Xu YT, Ni HB, Rui Q, Liu HX, Jiang F, Gao R, Chen G (2018) Inhibition of Lats1\/p\u2010YAP 1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of traumatic brain injury. CNS Neurosci Ther 24:906\u2013916","journal-title":"CNS Neurosci Ther"},{"key":"10526_CR68","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.trsl.2023.02.002","volume":"257","author":"W Li","year":"2023","unstructured":"Li W, Xu P, Kong L, Feng S, Shen N, Huang H, Wang W, Xu X, Wang X, Wang G, Zhang Y, Sun W, Hu W, Liu X (2023) Elabela-APJ axis mediates angiogenesis via YAP\/TAZ pathway in cerebral ischemia\/reperfusion injury. Transl Res 257:78\u201392","journal-title":"Transl Res"},{"key":"10526_CR69","volume":"57","author":"Z Li","year":"2024","unstructured":"Li Z, Lin J, Wu J, Suo J, Wang Z (2024) The Hippo signalling pathway in bone homeostasis: under the regulation of mechanics and aging. Cell Prolif 57:e13652","journal-title":"Cell Prolif"},{"key":"10526_CR70","doi-asserted-by":"crossref","first-page":"8176","DOI":"10.7150\/thno.113599","volume":"15","author":"D Li","year":"2025","unstructured":"Li D, Wei Y, Yang R, Luo X, Liu Y, Zhao W, Yang H, Wu Y, Wang Y, Huang Z (2025) An unrecognized mechanism of self-protection in degenerating neurons mediated by astrocytic YAP through Wnts\/\u03b2-catenin\/EAAT2 signaling in C9orf72-poly-GA mice. Theranostics 15:8176","journal-title":"Theranostics"},{"key":"10526_CR71","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jmst.2020.03.009","volume":"63","author":"L Lihuang","year":"2021","unstructured":"Lihuang L, Qiuyan G, Yanxiu L, Mindan L, Jun Y, Yunlong G, Qiang Z, Benqiang S, Xiumin W, Liang-cheng L (2021) Targeted combination therapy for glioblastoma by co-delivery of doxorubicin, YAP-siRNA and gold nanorods. J Mater Sci Technol 63:81\u201390","journal-title":"J Mater Sci Technol"},{"key":"10526_CR72","doi-asserted-by":"publisher","first-page":"7557","DOI":"10.1007\/s12035-019-1592-4","volume":"56","author":"A Litan","year":"2019","unstructured":"Litan A, Li Z, Tokhtaeva E, Kelly P, Vagin O, Langhans SA (2019) A functional interaction between Na,K-ATPase \u03b2(2)-subunit\/AMOG and NF2\/Merlin regulates growth factor signaling in cerebellar granule cells. Mol Neurobiol 56:7557\u20137571","journal-title":"Mol Neurobiol"},{"key":"10526_CR73","doi-asserted-by":"crossref","first-page":"37159","DOI":"10.1074\/jbc.M110.152942","volume":"285","author":"C-Y Liu","year":"2010","unstructured":"Liu C-Y, Zha Z-Y, Zhou X, Zhang H, Huang W, Zhao D, Li T, Chan SW, Lim CJ, Hong W (2010) The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF\u03b2-TrCP E3 ligase. J Biol Chem 285:37159\u201337169","journal-title":"J Biol Chem"},{"key":"10526_CR74","doi-asserted-by":"crossref","first-page":"5558","DOI":"10.1074\/jbc.M110.194019","volume":"286","author":"C-Y Liu","year":"2011","unstructured":"Liu C-Y, Lv X, Li T, Xu Y, Zhou X, Zhao S, Xiong Y, Lei Q-Y, Guan K-L (2011) PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ. J Biol Chem 286:5558\u20135566","journal-title":"J Biol Chem"},{"key":"10526_CR75","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1126\/science.aao4426","volume":"359","author":"MA Lodato","year":"2018","unstructured":"Lodato MA, Rodin RE, Bohrson CL, Coulter ME, Barton AR, Kwon M, Sherman MA, Vitzthum CM, Luquette LJ, Yandava CN (2018) Aging and neurodegeneration are associated with increased mutations in single human neurons. Science 359:555\u2013559","journal-title":"Science"},{"key":"10526_CR76","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cmet.2022.11.001","volume":"35","author":"C Lopez-Otin","year":"2023","unstructured":"Lopez-Otin C, Pietrocola F, Roiz-Valle D, Galluzzi L, Kroemer G (2023) Meta-hallmarks of aging and cancer. Cell Metab 35:12\u201335","journal-title":"Cell Metab"},{"key":"10526_CR77","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1146\/annurev-biochem-013118-111829","volume":"88","author":"S Ma","year":"2019","unstructured":"Ma S, Meng Z, Chen R, Guan K-L (2019) The Hippo pathway: biology and pathophysiology. Annu Rev Biochem 88:577\u2013604","journal-title":"Annu Rev Biochem"},{"key":"10526_CR78","volume":"14","author":"X Ma","year":"2023","unstructured":"Ma X, Xin D, She R, Liu D, Ge J, Mei Z (2023) Novel insight into cGAS-STING pathway in ischemic stroke: from pre-to post-disease. Front Immunol 14:1275408","journal-title":"Front Immunol"},{"key":"10526_CR79","first-page":"4749","volume":"25","author":"Y Mao","year":"2016","unstructured":"Mao Y, Chen X, Xu M, Fujita K, Motoki K, Sasabe T, Homma H, Murata M, Tagawa K, Tamura T (2016) Targeting TEAD\/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington\u2019s disease pathology. Hum Mol Genet 25:4749\u20134770","journal-title":"Hum Mol Genet"},{"key":"10526_CR80","volume":"16","author":"VS Meli","year":"2023","unstructured":"Meli VS, Veerasubramanian PK, Downing TL, Wang W, Liu WF (2023) Mechanosensation to inflammation: roles for YAP\/TAZ in innate immune cells. Sci Signal 16:eadc9656","journal-title":"Sci Signal"},{"key":"10526_CR81","doi-asserted-by":"crossref","first-page":"C810","DOI":"10.1152\/ajpcell.00683.2023","volume":"326","author":"J Melrose","year":"2024","unstructured":"Melrose J (2024) Hippo cell signaling and HS-proteoglycans regulate tissue form and function, age-dependent maturation, extracellular matrix remodeling, and repair. Am J Physiol Cell Physiol 326:C810\u2013C828","journal-title":"Am J Physiol Cell Physiol"},{"key":"10526_CR82","doi-asserted-by":"crossref","DOI":"10.3390\/cells14010013","volume":"14","author":"C Miyajima","year":"2024","unstructured":"Miyajima C, Nagasaka M, Aoki H, Toriuchi K, Yamanaka S, Hashiguchi S, Morishita D, Aoyama M, Hayashi H, Inoue Y (2024) The Hippo signaling pathway manipulates cellular senescence. Cells 14:13","journal-title":"Cells"},{"key":"10526_CR83","doi-asserted-by":"crossref","first-page":"5767535","DOI":"10.1155\/2024\/5767535","volume":"2024","author":"S Mohammadpour","year":"2024","unstructured":"Mohammadpour S, Torshizi Esfahani A, Sarpash S, Vakili F, Zafarjafarzadeh N, Mashaollahi A, Pardakhtchi A, Nazemalhosseini-Mojarad E (2024) Hippo signaling pathway in colorectal cancer: modulation by various signals and therapeutic potential. Anal Cell Pathol 2024:5767535","journal-title":"Anal Cell Pathol"},{"key":"10526_CR84","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/jnr.21902","volume":"87","author":"N Morimoto","year":"2009","unstructured":"Morimoto N, Nagai M, Miyazaki K, Kurata T, Takehisa Y, Ikeda Y, Kamiya T, Okazawa H, Abe K (2009) Progressive decrease in the level of YAPdeltaCs, prosurvival isoforms of YAP, in the spinal cord of transgenic mouse carrying a mutant SOD1 gene. J Neurosci Res 87:928\u2013936","journal-title":"J Neurosci Res"},{"key":"10526_CR85","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(23)01478-2","volume":"403","author":"HR Morris","year":"2024","unstructured":"Morris HR, Spillantini MG, Sue CM, Williams-Gray CH (2024) The pathogenesis of Parkinson\u2019s disease. Lancet 403:293\u2013304","journal-title":"Lancet"},{"key":"10526_CR86","doi-asserted-by":"crossref","DOI":"10.3390\/cells11152449","volume":"11","author":"I Mourkioti","year":"2022","unstructured":"Mourkioti I, Angelopoulou A, Belogiannis K, Lagopati N, Potamianos S, Kyrodimos E, Gorgoulis V, Papaspyropoulos A (2022) Interplay of developmental Hippo\u2013Notch signaling pathways with the DNA damage response in prostate cancer. Cells 11:2449","journal-title":"Cells"},{"issue":"1","key":"10526_CR87","doi-asserted-by":"publisher","first-page":"11355","DOI":"10.1038\/s41598-018-29319-4","volume":"8","author":"KA Mueller","year":"2018","unstructured":"Mueller KA, Glajch KE, Huizenga MN, Wilson RA, Granucci EJ, Dios AM, Tousley AR, Iuliano M, Weisman E, LaQuaglia MJ (2018) Hippo signaling pathway dysregulation in human Huntington\u2019s disease brain and neuronal stem cells. Sci Rep 8:11355","journal-title":"Sci Rep"},{"issue":"1","key":"10526_CR88","doi-asserted-by":"publisher","first-page":"4625","DOI":"10.1038\/s41598-020-61490-5","volume":"10","author":"T Mukhtar","year":"2020","unstructured":"Mukhtar T, Breda J, Grison A, Karimaddini Z, Grobecker P, Iber D, Beisel C, van Nimwegen E, Taylor V (2020) Tead transcription factors differentially regulate cortical development. Sci Rep 10:4625","journal-title":"Sci Rep"},{"key":"10526_CR89","first-page":"34","volume":"2","author":"A Navarro","year":"2010","unstructured":"Navarro A, Boveris A (2010) Brain mitochondrial dysfunction in aging, neurodegeneration, and Parkinson\u2019s disease. Frontiers Aging Neurosci 2:34","journal-title":"Frontiers Aging Neurosci"},{"key":"10526_CR90","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcac288","volume":"4","author":"DG Nelles","year":"2022","unstructured":"Nelles DG, Hazrati LN (2022) Ependymal cells and neurodegenerative disease: outcomes of compromised ependymal barrier function. Brain Commun 4:fcac288","journal-title":"Brain Commun"},{"key":"10526_CR91","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3390\/cancers10040121","volume":"10","author":"TH Nguyen","year":"2018","unstructured":"Nguyen TH, Kugler J-M (2018) Ubiquitin-dependent regulation of the mammalian hippo pathway: therapeutic implications for cancer. Cancers (Basel) 10:121","journal-title":"Cancers (Basel)"},{"key":"10526_CR92","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002284RR","volume":"35","author":"AT Nguyen-Lefebvre","year":"2021","unstructured":"Nguyen-Lefebvre AT, Selzner N, Wrana JL, Bhat M (2021) The hippo pathway: a master regulator of liver metabolism, regeneration, and disease. FASEB J 35:e21570","journal-title":"FASEB J"},{"key":"10526_CR93","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1007\/s12035-024-04285-3","volume":"62","author":"A Ortega","year":"2025","unstructured":"Ortega A, Chernicki B, Ou G, Parmar MS (2025) From lab bench to hope: emerging gene therapies in clinical trials for Alzheimer\u2019s disease. Mol Neurobiol 62:1112\u20131135","journal-title":"Mol Neurobiol"},{"key":"10526_CR94","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22137164","volume":"22","author":"B Panizzutti","year":"2021","unstructured":"Panizzutti B, Bortolasci CC, Spolding B, Kidnapillai S, Connor T, Richardson MF, Truong TT, Liu ZS, Morris G, Gray L (2021) Transcriptional modulation of the hippo signaling pathway by drugs used to treat bipolar disorder and schizophrenia. Int J Mol Sci 22:7164","journal-title":"Int J Mol Sci"},{"key":"10526_CR95","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1126\/science.1129837","volume":"314","author":"A Papassotiropoulos","year":"2006","unstructured":"Papassotiropoulos A, Stephan DA, Huentelman MJ, Hoerndli FJ, Craig DW, Pearson JV, Huynh KD, Brunner F, Corneveaux J, Osborne D, Wollmer MA, Aerni A, Coluccia D, H\u00e4nggi J, Mondadori CR, Buchmann A, Reiman EM, Caselli RJ, Henke K, de Quervain DJ (2006) Common Kibra alleles are associated with human memory performance. Science 314:475\u2013478","journal-title":"Science"},{"key":"10526_CR96","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10329","volume":"7","author":"R Park","year":"2016","unstructured":"Park R, Moon UY, Park JY, Hughes LJ, Johnson RL, Cho S-H, Kim S (2016) Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus. Nat Commun 7:10329","journal-title":"Nat Commun"},{"key":"10526_CR97","doi-asserted-by":"crossref","first-page":"16148","DOI":"10.1073\/pnas.1409802111","volume":"111","author":"MM Pathak","year":"2014","unstructured":"Pathak MM, Nourse JL, Tran T, Hwe J, Arulmoli J, Le DTT, Bernardis E, Flanagan LA, Tombola F (2014) Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells. Proc Natl Acad Sci U S A 111:16148\u201316153","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10526_CR98","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.molcel.2017.10.010","volume":"68","author":"C Peng","year":"2017","unstructured":"Peng C, Zhu Y, Zhang W, Liao Q, Chen Y, Zhao X, Guo Q, Shen P, Zhen B, Qian X (2017) Regulation of the Hippo-YAP pathway by glucose sensor O-GlcNAcylation. Mol Cell 68:591-604. e595","journal-title":"Mol Cell"},{"key":"10526_CR99","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1152\/physrev.00005.2014","volume":"94","author":"S Piccolo","year":"2014","unstructured":"Piccolo S, Dupont S, Cordenonsi M (2014) The biology of YAP\/TAZ: hippo signaling and beyond. Physiol Rev 94:1287\u20131312","journal-title":"Physiol Rev"},{"key":"10526_CR100","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73075","volume":"11","author":"FM Piccolo","year":"2022","unstructured":"Piccolo FM, Kastan NR, Haremaki T, Tian Q, Laundos TL, De Santis R, Beaudoin AJ, Carroll TS, Luo J-D, Gnedeva K (2022) Role of YAP in early ectodermal specification and a Huntington\u2019s disease model of human neurulation. Elife 11:e73075","journal-title":"Elife"},{"key":"10526_CR101","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1089\/dna.2019.5308","volume":"39","author":"J Qing","year":"2020","unstructured":"Qing J, Liu X, Wu Q, Zhou M, Zhang Y, Mazhar M, Huang X, Wang L, He F (2020) Hippo\/YAP pathway plays a critical role in effect of GDNF against A\u03b2-induced inflammation in microglial cells. DNA Cell Biol 39:1064\u20131071","journal-title":"DNA Cell Biol"},{"key":"10526_CR102","first-page":"6470957","volume":"2018","author":"J Qu","year":"2018","unstructured":"Qu J, Zhao H, Li Q, Pan P, Ma K, Liu X, Feng H, Chen Y (2018) MST1 suppression reduces early brain injury by inhibiting the NF-\u03baB\/MMP-9 pathway after subarachnoid hemorrhage in mice. Behav Neurol 2018:6470957","journal-title":"Behav Neurol"},{"key":"10526_CR103","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/stem.2489","volume":"35","author":"S Rammensee","year":"2017","unstructured":"Rammensee S, Kang MS, Georgiou K, Kumar S, Schaffer DV (2017) Dynamics of mechanosensitive neural stem cell differentiation. Stem Cells 35:497\u2013506","journal-title":"Stem Cells"},{"key":"10526_CR104","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2026.01.003","author":"DL Rebolledo","year":"2026","unstructured":"Rebolledo DL, Khan M, Melov S, Hoke A (2026) Senescent Schwann cells as therapeutic targets in nerve regeneration and peripheral neuropathies. Trends Mol Med. https:\/\/doi.org\/10.1016\/j.molmed.2026.01.003","journal-title":"Trends Mol Med"},{"key":"10526_CR105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000253","volume":"17","author":"KO Rojek","year":"2019","unstructured":"Rojek KO, Krzemie\u0144 J, Dole\u017cyczek H, Boguszewski PM, Kaczmarek L, Konopka W, Rylski M, Jaworski J, Holmgren L, Pr\u00f3szy\u0144ski TJ (2019) Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice. PLoS Biol 17:e3000253","journal-title":"PLoS Biol"},{"key":"10526_CR106","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.45961","author":"A Roy","year":"2019","unstructured":"Roy A, Murphy RM, Deng M, MacDonald JW, Bammler TK, Aldinger KA, Glass IA, Millen KJ (2019) PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice. Elife. https:\/\/doi.org\/10.7554\/eLife.45961","journal-title":"Elife"},{"key":"10526_CR107","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/jnr.24551","volume":"98","author":"MR Sahu","year":"2020","unstructured":"Sahu MR, Mondal AC (2020) The emerging role of Hippo signaling in neurodegeneration. J Neurosci Res 98:796\u2013814","journal-title":"J Neurosci Res"},{"key":"10526_CR108","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/dneu.22796","volume":"81","author":"MR Sahu","year":"2021","unstructured":"Sahu MR, Mondal AC (2021) Neuronal Hippo signaling: from development to diseases. Dev Neurobiol 81:92\u2013109","journal-title":"Dev Neurobiol"},{"key":"10526_CR109","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1007\/s10495-024-01975-0","volume":"29","author":"MR Sahu","year":"2024","unstructured":"Sahu MR, Ahmad MH, Mondal AC (2024) MST1 selective inhibitor Xmu-mp-1 ameliorates neuropathological changes in a rat model of sporadic Alzheimer\u2019s disease by modulating Hippo-Wnt signaling crosstalk. Apoptosis 29:1824\u20131851","journal-title":"Apoptosis"},{"key":"10526_CR110","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s13105-022-00904-6","volume":"78","author":"H Shang","year":"2022","unstructured":"Shang H, VanDusseldorp TA, Ma R, Zhao Y, Cholewa J, Zanchi NE, Xia Z (2022) Role of MST1 in the regulation of autophagy and mitophagy: implications for aging-related diseases. J Physiol Biochem 78:709\u2013719","journal-title":"J Physiol Biochem"},{"key":"10526_CR111","doi-asserted-by":"crossref","DOI":"10.1016\/j.bspc.2021.103217","volume":"71","author":"JV Shanmugam","year":"2022","unstructured":"Shanmugam JV, Duraisamy B, Simon BC, Bhaskaran P (2022) Alzheimer\u2019s disease classification using pre-trained deep networks. Biomed Signal Process Control 71:103217","journal-title":"Biomed Signal Process Control"},{"key":"10526_CR112","doi-asserted-by":"crossref","DOI":"10.3390\/cells11223631","volume":"11","author":"P Sileo","year":"2022","unstructured":"Sileo P, Simonin C, Melnyk P, Chartier-Harlin M-C, Cotelle P (2022a) Crosstalk between the Hippo pathway and the Wnt pathway in Huntington\u2019s disease and other neurodegenerative disorders. Cells 11:3631","journal-title":"Cells"},{"key":"10526_CR113","doi-asserted-by":"publisher","DOI":"10.3390\/cells11223631","author":"P Sileo","year":"2022","unstructured":"Sileo P, Simonin C, Melnyk P, Chartier-Harlin MC, Cotelle P (2022b) Crosstalk between the Hippo pathway and the Wnt pathway in Huntington\u2019s disease and other neurodegenerative disorders. Cells. https:\/\/doi.org\/10.3390\/cells11223631","journal-title":"Cells"},{"key":"10526_CR114","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/s41586-022-04924-6","volume":"607","author":"HL Sladitschek-Martens","year":"2022","unstructured":"Sladitschek-Martens HL, Guarnieri A, Brumana G, Zanconato F, Battilana G, Xiccato RL, Panciera T, Forcato M, Bicciato S, Guzzardo V (2022) YAP\/TAZ activity in stromal cells prevents ageing by controlling cGAS\u2013STING. Nature 607:790\u2013798","journal-title":"Nature"},{"key":"10526_CR115","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","volume":"119","author":"MV Sofroniew","year":"2010","unstructured":"Sofroniew MV, Vinters HV (2010) Astrocytes: biology and pathology. Acta Neuropathol 119:7\u201335","journal-title":"Acta Neuropathol"},{"key":"10526_CR116","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.adj6603","volume":"17","author":"J Stepan","year":"2024","unstructured":"Stepan J, Heinz DE, Dethloff F, Wiechmann S, Martinelli S, Hafner K, Ebert T, Junglas E, H\u00e4usl AS, P\u00f6hlmann ML, Jakovcevski M, Pape JC, Zannas AS, Bajaj T, Hermann A, Ma X, Pavenst\u00e4dt H, Schmidt MV, Philipsen A, Turck CW, Deussing JM, Rammes G, Robinson AC, Payton A, Wehr MC, Stein V, Murgatroyd C, Kremerskothen J, Kuster B, Wotjak CT, Gassen NC (2024) Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice. Sci Signal 17:eadj6603","journal-title":"Sci Signal"},{"key":"10526_CR117","doi-asserted-by":"publisher","first-page":"5044","DOI":"10.1007\/s12035-020-02069-z","volume":"57","author":"W Sun","year":"2020","unstructured":"Sun W, Zhao J, Li C (2020) Dexmedetomidine provides protection against hippocampal neuron apoptosis and cognitive impairment in mice with Alzheimer\u2019s disease by mediating the miR-129\/YAP1\/JAG1 axis. Mol Neurobiol 57:5044\u20135055","journal-title":"Mol Neurobiol"},{"key":"10526_CR118","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2026.112208","author":"S Tan","year":"2026","unstructured":"Tan S, Huang X, Li J, Nepovimova E, Valko M, Wu Q, Kuca K (2026) The Hippo-YAP\/TAZ axis: a central signaling hub integrating diverse cues to regulate cellular senescence. Mech Ageing Dev. https:\/\/doi.org\/10.1016\/j.mad.2026.112208","journal-title":"Mech Ageing Dev"},{"key":"10526_CR119","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14353-6","volume":"11","author":"H Tanaka","year":"2020","unstructured":"Tanaka H, Homma H, Fujita K, Kondo K, Yamada S, Jin X, Waragai M, Ohtomo G, Iwata A, Tagawa K (2020) YAP-dependent necrosis occurs in early stages of Alzheimer\u2019s disease and regulates mouse model pathology. Nat Commun 11:507","journal-title":"Nat Commun"},{"key":"10526_CR120","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1002\/dvdy.504","volume":"251","author":"BK Terry","year":"2022","unstructured":"Terry BK, Kim S (2022a) The role of Hippo-YAP\/TAZ signaling in brain development. Dev Dyn 251:1644\u20131665","journal-title":"Dev Dyn"},{"key":"10526_CR121","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1002\/dvdy.504","volume":"251","author":"BK Terry","year":"2022","unstructured":"Terry BK, Kim S (2022b) The role of Hippo\u2010YAP\/TAZ signaling in brain development. Dev Dyn 251:1644\u20131665","journal-title":"Dev Dyn"},{"key":"10526_CR122","volume":"25","author":"H Tong","year":"2024","unstructured":"Tong H, Yang T, Xu S, Li X, Liu L, Zhou G, Yang S, Yin S, Li X-J, Li S (2024) Huntington\u2019s disease: complex pathogenesis and therapeutic strategies. Int J Mol Sci 25:3845","journal-title":"Int J Mol Sci"},{"key":"10526_CR123","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1001\/jamaneurol.2021.4346","volume":"79","author":"K Toyoda","year":"2022","unstructured":"Toyoda K, Yoshimura S, Nakai M, Koga M, Sasahara Y, Sonoda K, Kamiyama K, Yazawa Y, Kawada S, Sasaki M (2022) Twenty-year change in severity and outcome of ischemic and hemorrhagic strokes. JAMA Neurol 79:61\u201369","journal-title":"JAMA Neurol"},{"key":"10526_CR124","first-page":"504","volume":"143","author":"J Wang","year":"2016","unstructured":"Wang J, Xiao Y, Hsu CW, Martinez-Traverso IM, Zhang M, Bai Y, Ishii M, Maxson RE, Olson EN, Dickinson ME, Wythe JD, Martin JF (2016) Yap and Taz play a crucial role in neural crest-derived craniofacial development. Development 143:504\u2013515","journal-title":"Development"},{"key":"10526_CR125","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/cns.14056","volume":"29","author":"Q Wang","year":"2023","unstructured":"Wang Q, Xu S, Wang B, Qin Y, Ji Y, Yang Q, Xu Y, Zhou Z (2023) Chemokine receptor 7 mediates miRNA-182 to regulate cerebral ischemia\/reperfusion injury in rats. CNS Neurosci Ther 29:712\u2013726","journal-title":"CNS Neurosci Ther"},{"key":"10526_CR126","doi-asserted-by":"crossref","first-page":"887","DOI":"10.4103\/NRR.NRR-D-23-01592","volume":"20","author":"J Wang","year":"2025","unstructured":"Wang J, Ran Y, Li Z, Zhao T, Zhang F, Wang J, Liu Z, Chen X (2025a) Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy. Neural Regen Res 20:887\u2013899","journal-title":"Neural Regen Res"},{"key":"10526_CR127","volume":"352","author":"S Wang","year":"2025","unstructured":"Wang S, Zhang X, Bai Y, Shi J, Sun Y, Wu H (2025b) Shengxian decoction alleviates experimental autoimmune myasthenia gravis by enhancing the immunosuppressive activity of regulatory T cells via Hippo pathway. J Ethnopharmacol 352:120250","journal-title":"J Ethnopharmacol"},{"key":"10526_CR128","volume":"162","author":"X Wei","year":"2023","unstructured":"Wei X, Huang G, Liu J, Ge J, Zhang W, Mei Z (2023) An update on the role of Hippo signaling pathway in ischemia-associated central nervous system diseases. Biomed Pharmacother 162:114619","journal-title":"Biomed Pharmacother"},{"key":"10526_CR129","volume":"16","author":"J Wen","year":"2025","unstructured":"Wen J, Cheng G, Zhang Y, Liu S (2025) Hippo signaling pathway in polycystic ovary syndrome. Front Endocrinol (Lausanne) 16:1623143","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10526_CR130","volume":"20","author":"X Xu","year":"2021","unstructured":"Xu X, Shen X, Wang J, Feng W, Wang M, Miao X, Wu Q, Wu L, Wang X, Ma Y (2021a) YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer\u2019s disease through regulating CDK6 signaling. Aging Cell 20:e13465","journal-title":"Aging Cell"},{"key":"10526_CR131","volume":"20","author":"X Xu","year":"2021","unstructured":"Xu X, Shen X, Wang J, Feng W, Wang M, Miao X, Wu Q, Wu L, Wang X, Ma Y, Wu S, Bao X, Wang W, Wang Y, Huang Z (2021b) YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer\u2019s disease through regulating CDK6 signaling. Aging Cell 20:e13465","journal-title":"Aging Cell"},{"key":"10526_CR132","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40478-017-0420-1","volume":"5","author":"E Yamanishi","year":"2017","unstructured":"Yamanishi E, Hasegawa K, Fujita K, Ichinose S, Yagishita S, Murata M, Tagawa K, Akashi T, Eishi Y, Okazawa H (2017) A novel form of necrosis, TRIAD, occurs in human Huntington\u2019s disease. Acta Neuropathol Commun 5:19","journal-title":"Acta Neuropathol Commun"},{"key":"10526_CR133","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.ydbio.2019.07.018","volume":"455","author":"Z Yang","year":"2019","unstructured":"Yang Z, Joyner AL (2019) YAP1 is involved in replenishment of granule cell precursors following injury to the neonatal cerebellum. Dev Biol 455:458\u2013472","journal-title":"Dev Biol"},{"key":"10526_CR134","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2026.122223","author":"X Yu","year":"2026","unstructured":"Yu X, Wu Y, Su W, Tang J, Yang Q, Huang P, Zhao B, Cao G, Yang Q (2026) Jiajian Shuyu pills ameliorates cerebral ischemia-reperfusion injury by regulation Hippo signaling and the lipid metabolism-ferroptosis axis. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2026.122223","journal-title":"J Ethnopharmacol"},{"key":"10526_CR135","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25145-x","volume":"12","author":"T Yuan","year":"2021","unstructured":"Yuan T, Annamalai K, Naik S, Lupse B, Geravandi S, Pal A, Dobrowolski A, Ghawali J, Ruhlandt M, Gorrepati KDD (2021) The Hippo kinase LATS2 impairs pancreatic \u03b2-cell survival in diabetes through the mTORC1-autophagy axis. Nat Commun 12:4928","journal-title":"Nat Commun"},{"key":"10526_CR136","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1177\/0271678X241252110","volume":"45","author":"Y Yuan","year":"2025","unstructured":"Yuan Y, Yang X, Zhao Y, Flores JJ, Huang L, Gu L, Li R, Zhang X, Zhu S, Dong S (2025) Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1\/Yap pathway in a neonatal rat model of germinal matrix hemorrhage. J Cereb Blood Flow Metab 45:510\u2013527","journal-title":"J Cereb Blood Flow Metab"},{"key":"10526_CR137","volume":"30","author":"Q Yue","year":"2024","unstructured":"Yue Q, Leng X, Xie N, Zhang Z, Yang D, Hoi MPM (2024) Endothelial dysfunctions in blood-brain barrier breakdown in Alzheimer\u2019s disease: from mechanisms to potential therapies. CNS Neurosci Ther 30:e70079","journal-title":"CNS Neurosci Ther"},{"key":"10526_CR138","doi-asserted-by":"crossref","first-page":"758","DOI":"10.3390\/biomedicines14040758","volume":"14","author":"M Zawadzka","year":"2026","unstructured":"Zawadzka M, Rydzek J, Lizon J, Krupa Z, Wrona J, Wo\u017aniak S (2026) Cellular senescence in neurodegeneration: from cell types to therapeutic opportunities. Biomedicines 14:758","journal-title":"Biomedicines"},{"key":"10526_CR139","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1007\/s13311-022-01198-8","volume":"19","author":"M-L Zeng","year":"2022","unstructured":"Zeng M-L, Cheng J-J, Kong S, Yang X-L, Jia X-L, Cheng X-L, Chen L, He F-G, Liu Y-M, Fan Y-T, Gongga L, Chen T-X, Liu W-H, He X-H, Peng B-W (2022) Inhibition of transient receptor potential vanilloid 4 (TRPV4) mitigates seizures. Neurotherapeutics 19:660\u2013681","journal-title":"Neurotherapeutics"},{"key":"10526_CR140","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s12975-019-00702-1","volume":"10","author":"P Zhang","year":"2019","unstructured":"Zhang P, Wang T, Zhang D, Zhang Z, Yuan S, Zhang J, Cao J, Li H, Li X, Shen H (2019) Exploration of MST1-mediated secondary brain injury induced by intracerebral hemorrhage in rats via hippo signaling pathway. Transl Stroke Res 10:729\u2013743","journal-title":"Transl Stroke Res"},{"key":"10526_CR141","volume":"9","author":"W Zhang","year":"2022","unstructured":"Zhang W, Li Q-q, Gao H-y, Wang Y-c, Cheng M, Wang Y-X (2022) The regulation of yes-associated protein\/transcriptional coactivator with PDZ-binding motif and their roles in vascular endothelium. Front Cardiovasc Med 9:925254","journal-title":"Front Cardiovasc Med"},{"key":"10526_CR142","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1186\/s40001-025-02886-9","volume":"30","author":"J Zhang","year":"2025","unstructured":"Zhang J, Kong G, Yang J, Pang L, Li X (2025a) Pathological mechanisms and treatment progression of Alzheimer\u2019s disease. Eur J Med Res 30:625","journal-title":"Eur J Med Res"},{"key":"10526_CR143","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1038\/s41556-025-01685-y","volume":"27","author":"J Zhang","year":"2025","unstructured":"Zhang J, Hu J, Liu R, Zhou T, Luo X, Liang P, Xie Z, Zhao Q, Chen Y, Du D (2025b) YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates. Nat Cell Biol 27:1148\u20131160","journal-title":"Nat Cell Biol"},{"key":"10526_CR144","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.bbi.2015.12.016","volume":"55","author":"S Zhao","year":"2016","unstructured":"Zhao S, Yin J, Zhou L, Yan F, He Q, Huang L, Peng S, Jia J, Cheng J, Chen H, Tao W, Ji X, Xu Y, Yuan Z (2016) Hippo\/MST1 signaling mediates microglial activation following acute cerebral ischemia\u2013reperfusion injury. Brain Behav Immun 55:236\u2013248","journal-title":"Brain Behav Immun"},{"key":"10526_CR145","doi-asserted-by":"publisher","DOI":"10.1177\/08977151251401226","author":"R Zhao","year":"2025","unstructured":"Zhao R, Gao S-Q, Wang X, Li T, Gao C-C, Han Y-L, Qiu J-Y, Miao S-H, Sun Y, Zheng X-B (2025) YAP regulates microglial anti-inflammatory responses and alleviates cognitive impairment through the IL-33\/ST2 pathway after traumatic brain injury. J Neurotrauma. https:\/\/doi.org\/10.1177\/08977151251401226","journal-title":"J Neurotrauma"},{"key":"10526_CR146","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/s41419-025-08055-4","volume":"16","author":"H Zheng","year":"2025","unstructured":"Zheng H, Guo Y, Zhang S, Su Y, Cui X, Hu Z, Hao X, Li M, Shi C, Xu Y (2025) Insulin-degrading enzyme confers neuroprotection in Parkinson\u2019s disease by inhibiting the Hippo signaling pathway. Cell Death Dis 16:758","journal-title":"Cell Death Dis"},{"key":"10526_CR147","volume":"43","author":"Z Zhong","year":"2024","unstructured":"Zhong Z, Jiao Z, Yu FX (2024) The Hippo signaling pathway in development and regeneration. Cell Rep 43:113926","journal-title":"Cell Rep"},{"key":"10526_CR148","volume":"24","author":"W Zhou","year":"2023","unstructured":"Zhou W, Lei B, Yang C, Silva M, Xing X, Yu H, Lu J, Zheng W (2023) Artemisia annua extract improves the cognitive deficits and reverses the pathological changes of Alzheimer\u2019s disease via regulating YAP signaling. Int J Mol Sci 24:5259","journal-title":"Int J Mol Sci"},{"key":"10526_CR149","doi-asserted-by":"crossref","first-page":"e464","DOI":"10.1016\/S2666-7568(24)00094-1","volume":"5","author":"J Zhu","year":"2024","unstructured":"Zhu J, Cui Y, Zhang J, Yan R, Su D, Zhao D, Wang A, Feng T (2024a) Temporal trends in the prevalence of Parkinson\u2019s disease from 1980 to 2023: a systematic review and meta-analysis. Lancet Healthy Longev 5:e464\u2013e479","journal-title":"Lancet Healthy Longev"},{"key":"10526_CR150","volume":"375","author":"X Zhu","year":"2024","unstructured":"Zhu X, Chu X, Wang H, Liao Z, Xiang H, Zhao W, Yang L, Wu P, Liu X, Chen D (2024b) Investigating neuropathological changes and underlying neurobiological mechanisms in the early stages of primary blast-induced traumatic brain injury: insights from a rat model. Exp Neurol 375:114731","journal-title":"Exp Neurol"},{"key":"10526_CR151","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s10753-016-0457-5","volume":"40","author":"R Zou","year":"2017","unstructured":"Zou R, Li D, Wang G, Zhang M, Zhao Y, Yang Z (2017) TAZ activator is involved in IL-10-mediated muscle responses in an animal model of traumatic brain injury. Inflammation 40:100\u2013105","journal-title":"Inflammation"}],"container-title":["Biogerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-026-10526-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10522-026-10526-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-026-10526-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:02:13Z","timestamp":1791997333000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10522-026-10526-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":151,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10526"],"URL":"https:\/\/doi.org\/10.1007\/s10522-026-10526-w","relation":{},"ISSN":["1389-5729","1573-6768"],"issn-type":[{"value":"1389-5729","type":"print"},{"value":"1573-6768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"assertion":[{"value":"2 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"177"}}