{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:45:40Z","timestamp":1792259140144,"version":"4.4.0"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biogerontology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10522-026-10529-7","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:06:12Z","timestamp":1792224372000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Finasteride exposure on lifespan and locomotor phenotypes"],"prefix":"10.1007","volume":"27","author":[{"given":"Keyao","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyi","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1911-8397","authenticated-orcid":false,"given":"Menglong","family":"Rui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,17]]},"reference":[{"issue":"13","key":"10529_CR1","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1056\/NEJMoa0908127","volume":"362","author":"GL Andriole","year":"2010","unstructured":"Andriole GL, Bostwick DG, Brawley OW, Gomella LG, Marberger M, Montorsi F, Pettaway CA, Tammela TL, Teloken C, Tindall DJ, Somerville MC, Wilson TH, Fowler IL, Rittmaster RS, Group, R. S. (2010) Effect of dutasteride on the risk of prostate cancer. N Engl J Med 362(13):1192\u20131202. https:\/\/doi.org\/10.1056\/NEJMoa0908127","journal-title":"N Engl J Med"},{"issue":"5","key":"10529_CR2","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.jalz.2015.08.167","volume":"12","author":"E Ayers","year":"2016","unstructured":"Ayers E, Verghese J (2016) Motoric cognitive risk syndrome and risk of mortality in older adults. Alzheimers Dement 12(5):556\u2013564. https:\/\/doi.org\/10.1016\/j.jalz.2015.08.167","journal-title":"Alzheimers Dement"},{"key":"10529_CR3","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12729","author":"J Azpurua","year":"2018","unstructured":"Azpurua J, Mahoney RE, Eaton BA (2018) Transcriptomics of aged Drosophila motor neurons reveals a matrix metalloproteinase that impairs motor function. Aging Cell. https:\/\/doi.org\/10.1111\/acel.12729","journal-title":"Aging Cell"},{"key":"10529_CR4","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/530121","volume":"2012","author":"F Azzouni","year":"2012","unstructured":"Azzouni F, Godoy A, Li Y, Mohler J (2012) The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases. Adv Urol 2012:530121. https:\/\/doi.org\/10.1155\/2012\/530121","journal-title":"Adv Urol"},{"issue":"1","key":"10529_CR5","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.cmet.2009.11.010","volume":"11","author":"I Bjedov","year":"2010","unstructured":"Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, Foley A, Partridge L (2010) Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab 11(1):35\u201346. https:\/\/doi.org\/10.1016\/j.cmet.2009.11.010","journal-title":"Cell Metab"},{"issue":"4","key":"10529_CR6","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.top108172","volume":"2025","author":"LJ Borjon","year":"2025","unstructured":"Borjon LJ, Mauthner SE, Tracey WD (2025) Nociception in Drosophila larvae. Cold Spring Harb Protoc 2025(4):pdb top108172. https:\/\/doi.org\/10.1101\/pdb.top108172","journal-title":"Cold Spring Harb Protoc"},{"issue":"42","key":"10529_CR7","doi-asserted-by":"publisher","first-page":"20817","DOI":"10.1073\/pnas.1913212116","volume":"116","author":"JI Castillo-Quan","year":"2019","unstructured":"Castillo-Quan JI, Tain LS, Kinghorn KJ, Li L, Gronke S, Hinze Y, Blackwell TK, Bjedov I, Partridge L (2019) A triple drug combination targeting components of the nutrient-sensing network maximizes longevity. Proc Natl Acad Sci U S A 116(42):20817\u201320819. https:\/\/doi.org\/10.1073\/pnas.1913212116","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Pt 1","key":"10529_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.133844","volume":"276","author":"Y Chang","year":"2024","unstructured":"Chang Y, Zheng F, Chen M, Liu C, Zheng L (2024) Chlorella pyrenoidosa polysaccharides supplementation increases Drosophila melanogaster longevity at high temperature. Int J Biol Macromol 276(Pt 1):133844. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.133844","journal-title":"Int J Biol Macromol"},{"issue":"45","key":"10529_CR9","doi-asserted-by":"publisher","first-page":"16018","DOI":"10.1523\/Jneurosci.1685-12.2012","volume":"32","author":"YC Chen","year":"2012","unstructured":"Chen YC, Lin YQ, Banerjee S, Venken K, Li JJ, Ismat A, Li J, Chen K, Duraine L, Bellen HJ, Bhat MA (2012) Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission. J Neurosci 32(45):16018\u201316030. https:\/\/doi.org\/10.1523\/Jneurosci.1685-12.2012","journal-title":"J Neurosci"},{"issue":"39","key":"10529_CR10","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adt3560","volume":"11","author":"J Chen","year":"2025","unstructured":"Chen J, Liu C, Li W, Clark AG, Wang Z, Lu J (2025) Pervasive sex-dependent effects in the genetic architecture of starvation resistance in Drosophila melanogaster. Sci Adv 11(39):eadt3560. https:\/\/doi.org\/10.1126\/sciadv.adt3560","journal-title":"Sci Adv"},{"issue":"11","key":"10529_CR11","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1007\/s00018-018-2766-3","volume":"75","author":"E De Keuckelaere","year":"2018","unstructured":"De Keuckelaere E, Hulpiau P, Saeys Y, Berx G, van Roy F (2018) Nanos genes and their role in development and beyond. Cell Mol Life Sci 75(11):1929\u20131946. https:\/\/doi.org\/10.1007\/s00018-018-2766-3","journal-title":"Cell Mol Life Sci"},{"key":"10529_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2019.100209","volume":"12","author":"S Diviccaro","year":"2020","unstructured":"Diviccaro S, Melcangi RC, Giatti S (2020) Post-finasteride syndrome: an emerging clinical problem. Neurobiol Stress 12:100209. https:\/\/doi.org\/10.1016\/j.ynstr.2019.100209","journal-title":"Neurobiol Stress"},{"issue":"4","key":"10529_CR13","first-page":"550","volume":"41","author":"L Drake","year":"1999","unstructured":"Drake L, Hordinsky M, Fiedler V, Swinehart J, Unger WP, Cotterill PC, Waldstreicher J (1999) The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia. J Am Acad Dermatol 41(4):550\u2013554","journal-title":"J Am Acad Dermatol"},{"issue":"9","key":"10529_CR14","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1210\/en.2019-00114","volume":"160","author":"P Duarte-Guterman","year":"2019","unstructured":"Duarte-Guterman P, Lieblich SE, Wainwright SR, Chow C, Chaiton JA, Watson NV, Galea LAM (2019) Androgens enhance adult hippocampal neurogenesis in males but not females in an age-dependent manner. Endocrinology 160(9):2128\u20132136. https:\/\/doi.org\/10.1210\/en.2019-00114","journal-title":"Endocrinology"},{"key":"10529_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111247","volume":"137","author":"D Fu","year":"2021","unstructured":"Fu D, Huang J, Li K, Chen Y, He Y, Sun Y, Guo Y, Du L, Qu Q, Miao Y, Hu Z (2021) Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia. Biomed Pharmacother 137:111247. https:\/\/doi.org\/10.1016\/j.biopha.2021.111247","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"10529_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.108944","volume":"27","author":"Z Gao","year":"2024","unstructured":"Gao Z, Huang E, Wang W, Xu L, Xu W, Zheng T, Rui M (2024) Patronin regulates presynaptic microtubule organization and neuromuscular junction development in Drosophila. iScience 27(2):108944. https:\/\/doi.org\/10.1016\/j.isci.2024.108944","journal-title":"iScience"},{"issue":"6","key":"10529_CR17","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1016\/j.fertnstert.2012.03.025","volume":"97","author":"PV Garcia","year":"2012","unstructured":"Garcia PV, Barbieri MF, Perobelli JE, Consonni SR, Mesquita SF, Kempinas WG, Pereira LA (2012) Morphometric-stereological and functional epididymal alterations and a decrease in fertility in rats treated with finasteride and after a 30-day post-treatment recovery period. Fertil Steril 97(6):1444\u20131451. https:\/\/doi.org\/10.1016\/j.fertnstert.2012.03.025","journal-title":"Fertil Steril"},{"key":"10529_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/biom9110749","author":"SC Godar","year":"2019","unstructured":"Godar SC, Cadeddu R, Floris G, Mosher LJ, Mi Z, Jarmolowicz DP, Scheggi S, Walf AA, Koonce CJ, Frye CA, Muma NA, Bortolato M (2019) The steroidogenesis inhibitor finasteride reduces the response to both stressful and rewarding stimuli. Biomolecules. https:\/\/doi.org\/10.3390\/biom9110749","journal-title":"Biomolecules"},{"issue":"7276","key":"10529_CR19","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/nature08619","volume":"462","author":"RC Grandison","year":"2009","unstructured":"Grandison RC, Piper MD, Partridge L (2009) Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature 462(7276):1061\u20131064. https:\/\/doi.org\/10.1038\/nature08619","journal-title":"Nature"},{"issue":"3","key":"10529_CR20","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/S1474-4422(13)70278-3","volume":"13","author":"P Grandjean","year":"2014","unstructured":"Grandjean P, Landrigan PJ (2014) Neurobehavioural effects of developmental toxicity. Lancet Neurol 13(3):330\u2013338. https:\/\/doi.org\/10.1016\/S1474-4422(13)70278-3","journal-title":"Lancet Neurol"},{"key":"10529_CR21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l5047","volume":"366","author":"SL Gray","year":"2019","unstructured":"Gray SL, Semla TP (2019) Post-finasteride syndrome. BMJ 366:l5047. https:\/\/doi.org\/10.1136\/bmj.l5047","journal-title":"BMJ"},{"key":"10529_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/cells14100750","author":"Q Guo","year":"2025","unstructured":"Guo Q, Kouyama-Suzuki E, Shirai Y, Tabuchi K (2025) N-Terminal kinase inhibitor suppresses CASK deficiency-induced cerebellar granular cell death in MICPCH syndrome model mice. Cells. https:\/\/doi.org\/10.3390\/cells14100750","journal-title":"Cells"},{"issue":"8","key":"10529_CR23","doi-asserted-by":"publisher","first-page":"e2430223","DOI":"10.1001\/jamanetworkopen.2024.30223","volume":"7","author":"RJ Hamilton","year":"2024","unstructured":"Hamilton RJ, Chavarriaga J, Khurram N, Lau C, Luo J, Liu N, Finelli A (2024) 5-alpha reductase inhibitors and prostate cancer mortality. JAMA Netw Open 7(8):e2430223. https:\/\/doi.org\/10.1001\/jamanetworkopen.2024.30223","journal-title":"JAMA Netw Open"},{"key":"10529_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114265","volume":"159","author":"S Han","year":"2023","unstructured":"Han S, Xiu M, Li S, Shi Y, Wang X, Lin X, Cai H, Liu Y, He J (2023) Exposure to cytarabine causes side effects on adult development and physiology and induces intestinal damage via apoptosis in Drosophila. Biomed Pharmacother 159:114265. https:\/\/doi.org\/10.1016\/j.biopha.2023.114265","journal-title":"Biomed Pharmacother"},{"key":"10529_CR25","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0641-26.2026","author":"E Huang","year":"2026","unstructured":"Huang E, Yuan Y, Wang S, Xu X, Rui M (2026) Glia-derived Upd1 promotes dendritic remodeling via neuronal JAK\/Stat-CK2\u03b1 signaling. J Neurosci. https:\/\/doi.org\/10.1523\/jneurosci.0641-26.2026","journal-title":"J Neurosci"},{"issue":"9","key":"10529_CR26","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.4088\/JCP.12m07887","volume":"73","author":"MS Irwig","year":"2012","unstructured":"Irwig MS (2012) Depressive symptoms and suicidal thoughts among former users of finasteride with persistent sexual side effects. J Clin Psychiatry 73(9):1220\u20131223. https:\/\/doi.org\/10.4088\/JCP.12m07887","journal-title":"J Clin Psychiatry"},{"key":"10529_CR27","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jinsphys.2015.09.002","volume":"82","author":"T Jang","year":"2015","unstructured":"Jang T, Lee KP (2015) The genetic basis for mating-induced sex differences in starvation resistance in Drosophila melanogaster. J Insect Physiol 82:56\u201365. https:\/\/doi.org\/10.1016\/j.jinsphys.2015.09.002","journal-title":"J Insect Physiol"},{"issue":"4","key":"10529_CR28","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1111\/acel.12333","volume":"14","author":"K Jensen","year":"2015","unstructured":"Jensen K, McClure C, Priest NK, Hunt J (2015) Sex-specific effects of protein and carbohydrate intake on reproduction but not lifespan in Drosophila melanogaster. Aging Cell 14(4):605\u2013615. https:\/\/doi.org\/10.1111\/acel.12333","journal-title":"Aging Cell"},{"issue":"19","key":"10529_CR29","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/j.cub.2004.09.057","volume":"14","author":"P Kapahi","year":"2004","unstructured":"Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S (2004) Regulation of lifespan in Drosophila by modulation of genes in the TOR signalling pathway. Curr Biol 14(19):1789\u20131789. https:\/\/doi.org\/10.1016\/j.cub.2004.09.057","journal-title":"Curr Biol"},{"issue":"5","key":"10529_CR30","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.neuron.2007.08.002","volume":"55","author":"J Li","year":"2007","unstructured":"Li J, Ashley J, Budnik V, Bhat MA (2007) Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmission. Neuron 55(5):741\u2013755. https:\/\/doi.org\/10.1016\/j.neuron.2007.08.002","journal-title":"Neuron"},{"issue":"2","key":"10529_CR31","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/cns.12781","volume":"24","author":"L Li","year":"2018","unstructured":"Li L, Kang YX, Ji XM, Li YK, Li SC, Zhang XJ, Kang Y-X, Ji X-M, Li Y-K, Li S-C, Zhang X-J, Cui H-X, Shi G-M, Shi GM (2018) Finasteride inhibited brain dopaminergic system and open-field behaviors in adolescent male rats. CNS Neurosci Ther 24(2):115\u2013125. https:\/\/doi.org\/10.1111\/cns.12781","journal-title":"CNS Neurosci Ther"},{"key":"10529_CR32","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.bbi.2023.02.001","volume":"110","author":"J Li","year":"2023","unstructured":"Li J, Wang H, Liu D, Li X, He L, Pan J, Shen Q, Peng Y (2023) CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice. Brain Behav Immun 110:60\u201379. https:\/\/doi.org\/10.1016\/j.bbi.2023.02.001","journal-title":"Brain Behav Immun"},{"key":"10529_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1453582","volume":"18","author":"C Li","year":"2024","unstructured":"Li C, Cui K, Zhu X, Wang S, Yang Q, Fang G (2024) 8-weeks aerobic exercise ameliorates cognitive deficit and mitigates ferroptosis triggered by iron overload in the prefrontal cortex of APP (Swe)\/PSEN (1dE9) mice through Xc(-)\/GPx4 pathway. Front Neurosci 18:1453582. https:\/\/doi.org\/10.3389\/fnins.2024.1453582","journal-title":"Front Neurosci"},{"key":"10529_CR34","doi-asserted-by":"publisher","DOI":"10.3791\/50068","author":"NJ Linford","year":"2013","unstructured":"Linford NJ, Bilgir C, Ro J, Pletcher SD (2013) Measurement of lifespan in Drosophila melanogaster. J vis Exp. https:\/\/doi.org\/10.3791\/50068","journal-title":"J vis Exp"},{"key":"10529_CR35","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.76574","author":"Z Liu","year":"2022","unstructured":"Liu Z, Wu MH, Wang QX, Lin SZ, Feng XQ, Li B, Liang X (2022) Drosophila mechanical nociceptors preferentially sense localized poking. Elife. https:\/\/doi.org\/10.7554\/eLife.76574","journal-title":"Elife"},{"key":"10529_CR36","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf8896","author":"Y Luo","year":"2021","unstructured":"Luo Y, Johnson JC, Chakraborty TS, Piontkowski A, Gendron CM, Pletcher SD (2021) Yeast volatiles double starvation survival in Drosophila. Sci Adv. https:\/\/doi.org\/10.1126\/sciadv.abf8896","journal-title":"Sci Adv"},{"issue":"3","key":"10529_CR37","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1677\/jme.1.01725","volume":"34","author":"N Makridakis","year":"2005","unstructured":"Makridakis N, Reichardt JK (2005) Pharmacogenetic analysis of human steroid 5 alpha reductase type II: comparison of finasteride and dutasteride. J Mol Endocrinol 34(3):617\u2013623. https:\/\/doi.org\/10.1677\/jme.1.01725","journal-title":"J Mol Endocrinol"},{"issue":"11","key":"10529_CR38","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1249\/MSS.0000000000001683","volume":"50","author":"RP McGrath","year":"2018","unstructured":"McGrath RP, Vincent BM, Lee IM, Kraemer WJ, Peterson MD (2018) Handgrip strength, function, and mortality in older adults: a time-varying approach. Med Sci Sports Exerc 50(11):2259\u20132266. https:\/\/doi.org\/10.1249\/MSS.0000000000001683","journal-title":"Med Sci Sports Exerc"},{"issue":"10","key":"10529_CR39","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1001\/archdermatol.2010.256","volume":"146","author":"JM Mella","year":"2010","unstructured":"Mella JM, Perret MC, Manzotti M, Catalano HN, Guyatt G (2010) Efficacy and safety of finasteride therapy for androgenetic alopecia: a systematic review. Arch Dermatol 146(10):1141\u20131150. https:\/\/doi.org\/10.1001\/archdermatol.2010.256","journal-title":"Arch Dermatol"},{"issue":"7393","key":"10529_CR40","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nature10923","volume":"484","author":"TJ Mosca","year":"2012","unstructured":"Mosca TJ, Hong W, Dani VS, Favaloro V, Luo L (2012) Trans-synaptic teneurin signalling in neuromuscular synapse organization and target choice. Nature 484(7393):237\u2013241. https:\/\/doi.org\/10.1038\/nature10923","journal-title":"Nature"},{"issue":"5","key":"10529_CR41","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.eururo.2012.05.025","volume":"62","author":"RL Muller","year":"2012","unstructured":"Muller RL, Gerber L, Moreira DM, Andriole G, Castro-Santamaria R, Freedland SJ (2012) Serum testosterone and dihydrotestosterone and prostate cancer risk in the placebo arm of the Reduction by Dutasteride of Prostate Cancer Events trial. Eur Urol 62(5):757\u2013764. https:\/\/doi.org\/10.1016\/j.eururo.2012.05.025","journal-title":"Eur Urol"},{"issue":"1","key":"10529_CR42","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1038\/s41467-018-03070-w","volume":"9","author":"F Obata","year":"2018","unstructured":"Obata F, Fons CO, Gould AP (2018) Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila. Nat Commun 9(1):975. https:\/\/doi.org\/10.1038\/s41467-018-03070-w","journal-title":"Nat Commun"},{"issue":"9","key":"10529_CR43","doi-asserted-by":"publisher","first-page":"2707","DOI":"10.1016\/j.bbadis.2017.09.016","volume":"1864","author":"MDW Piper","year":"2018","unstructured":"Piper MDW, Partridge L (2018) Drosophila as a model for ageing. Biochim Biophys Acta Mol Basis Dis 1864(9):2707\u20132717. https:\/\/doi.org\/10.1016\/j.bbadis.2017.09.016","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10529_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/0471140856.tx0112s59","volume":"59","author":"MD Rand","year":"2014","unstructured":"Rand MD, Montgomery SL, Prince L, Vorojeikina D (2014) Developmental toxicity assays using the Drosophila model. Curr Protoc Toxicol 59:1-12 11-20. https:\/\/doi.org\/10.1002\/0471140856.tx0112s59","journal-title":"Curr Protoc Toxicol"},{"issue":"8","key":"10529_CR45","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.exger.2008.04.011","volume":"43","author":"D Rhodenizer","year":"2008","unstructured":"Rhodenizer D, Martin I, Bhandari P, Pletcher SD, Grotewiel M (2008) Genetic and environmental factors impact age-related impairment of negative geotaxis in Drosophila by altering age-dependent climbing speed. Exp Gerontol 43(8):739\u2013748. https:\/\/doi.org\/10.1016\/j.exger.2008.04.011","journal-title":"Exp Gerontol"},{"issue":"Suppl 3","key":"10529_CR46","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1289\/ehp.00108s3511","volume":"108","author":"D Rice","year":"2000","unstructured":"Rice D, Barone S Jr. (2000) Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect 108(Suppl 3):511\u2013533. https:\/\/doi.org\/10.1289\/ehp.00108s3511","journal-title":"Environ Health Perspect"},{"key":"10529_CR47","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.240059","author":"M Rui","year":"2024","unstructured":"Rui M (2024) Recent progress in dendritic pruning of Drosophila C4da sensory neurons. Open Biol. https:\/\/doi.org\/10.1098\/rsob.240059","journal-title":"Open Biol"},{"issue":"35","key":"10529_CR48","doi-asserted-by":"publisher","first-page":"14334","DOI":"10.1074\/jbc.M117.794040","volume":"292","author":"M Rui","year":"2017","unstructured":"Rui M, Qian J, Liu L, Cai Y, Lv H, Han J, Jia Z, Xie W (2017) The neuronal protein Neurexin directly interacts with the Scribble-Pix complex to stimulate F-actin assembly for synaptic vesicle clustering. J Biol Chem 292(35):14334\u201314348. https:\/\/doi.org\/10.1074\/jbc.M117.794040","journal-title":"J Biol Chem"},{"key":"10529_CR49","doi-asserted-by":"publisher","DOI":"10.1242\/dev.191155","author":"M Rui","year":"2020","unstructured":"Rui M, Bu S, Chew LY, Wang Q, Yu F (2020a) The membrane protein Raw regulates dendrite pruning via the secretory pathway. Development. https:\/\/doi.org\/10.1242\/dev.191155","journal-title":"Development"},{"issue":"5","key":"10529_CR50","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201948843","volume":"21","author":"M Rui","year":"2020","unstructured":"Rui M, Ng KS, Tang Q, Bu S, Yu F (2020b) Protein phosphatase PP2A regulates microtubule orientation and dendrite pruning in Drosophila. EMBO Rep 21(5):e48843. https:\/\/doi.org\/10.15252\/embr.201948843","journal-title":"EMBO Rep"},{"issue":"17","key":"10529_CR51","doi-asserted-by":"publisher","first-page":"13213","DOI":"10.3390\/ijms241713213","volume":"24","author":"M Rui","year":"2023","unstructured":"Rui M, Kong W, Wang W, Zheng T, Wang S, Xie W (2023) Droj2 facilitates somatosensory neurite sculpting via GTP-binding protein Arf102F in Drosophila. Int J Mol Sci 24(17):13213. https:\/\/doi.org\/10.3390\/ijms241713213","journal-title":"Int J Mol Sci"},{"key":"10529_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2025.107554","volume":"180","author":"KA Rybka","year":"2025","unstructured":"Rybka KA, Lafrican JJ, Meunier P, Reilly DM, Parra KE, Colon LM, Poulos AM, Zuloaga DG (2025) Dihydrotestosterone regulation of stress-related behaviors in mice exposed to subchronic variable stress. Psychoneuroendocrinology 180:107554. https:\/\/doi.org\/10.1016\/j.psyneuen.2025.107554","journal-title":"Psychoneuroendocrinology"},{"key":"10529_CR53","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.biopen.2017.03.003","volume":"4","author":"A Scaglione","year":"2017","unstructured":"Scaglione A, Montemiglio LC, Parisi G, Asteriti IA, Bruni R, Cerutti G, Vallone B (2017) Subcellular localization of the five members of the human steroid 5alpha-reductase family. Biochim Open 4:99\u2013106. https:\/\/doi.org\/10.1016\/j.biopen.2017.03.003","journal-title":"Biochim Open"},{"issue":"2","key":"10529_CR54","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.conb.2009.04.001","volume":"19","author":"KK Siwicki","year":"2009","unstructured":"Siwicki KK, Kravitz EA (2009) Fruitless, doublesex and the genetics of social behavior in Drosophila melanogaster. Curr Opin Neurobiol 19(2):200\u2013206. https:\/\/doi.org\/10.1016\/j.conb.2009.04.001","journal-title":"Curr Opin Neurobiol"},{"issue":"1","key":"10529_CR55","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1534\/genetics.110.123406","volume":"187","author":"JB Slawson","year":"2011","unstructured":"Slawson JB, Kuklin EA, Ejima A, Mukherjee K, Ostrovsky L, Griffith LC (2011) Central regulation of locomotor behavior of Drosophila melanogaster depends on a CASK isoform containing CaMK-like and L27 domains. Genetics 187(1):171\u2013184. https:\/\/doi.org\/10.1534\/genetics.110.123406","journal-title":"Genetics"},{"issue":"4","key":"10529_CR56","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.neures.2009.04.009","volume":"64","author":"MK Sun","year":"2009","unstructured":"Sun MK, Liu LJ, Zeng XK, Xu M, Liu L, Fang M, Xie W (2009) Genetic interaction between Neurexin and CAKI\/CMG is important for synaptic function in Drosophila neuromuscular junction. Neurosci Res 64(4):362\u2013371. https:\/\/doi.org\/10.1016\/j.neures.2009.04.009","journal-title":"Neurosci Res"},{"issue":"3","key":"10529_CR57","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1210\/er.2016-1067","volume":"38","author":"RS Swerdloff","year":"2017","unstructured":"Swerdloff RS, Dudley RE, Page ST, Wang C, Salameh WA (2017) Dihydrotestosterone: biochemistry, physiology, and clinical implications of elevated blood levels. Endocr Rev 38(3):220\u2013254. https:\/\/doi.org\/10.1210\/er.2016-1067","journal-title":"Endocr Rev"},{"issue":"1","key":"10529_CR58","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/aps.2014.18","volume":"36","author":"MH Tan","year":"2015","unstructured":"Tan MH, Li J, Xu HE, Melcher K, Yong EL (2015) Androgen receptor: structure, role in prostate cancer and drug discovery. Acta Pharmacol Sin 36(1):3\u201323. https:\/\/doi.org\/10.1038\/aps.2014.18","journal-title":"Acta Pharmacol Sin"},{"issue":"Pt 3","key":"10529_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.136491","volume":"281","author":"T Tang","year":"2024","unstructured":"Tang T, Li J, Zhang B, Wen L, Lu Y, Hu Q, Yu X-Q, Zhang J (2024) Loss of function in Drosophila transcription factor Dif delays brain development in larvae resulting in aging adult brain. Int J Biol Macromol 281(Pt 3):136491. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.136491","journal-title":"Int J Biol Macromol"},{"key":"10529_CR60","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12959","author":"S Terada","year":"2016","unstructured":"Terada S, Matsubara D, Onodera K, Matsuzaki M, Uemura T, Usui T (2016) Neuronal processing of noxious thermal stimuli mediated by dendritic Ca(2+) influx in Drosophila somatosensory neurons. Elife. https:\/\/doi.org\/10.7554\/eLife.12959","journal-title":"Elife"},{"issue":"2","key":"10529_CR61","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/s0092-8674(03)00272-1","volume":"113","author":"WD Tracey Jr.","year":"2003","unstructured":"Tracey WD Jr., Wilson RI, Laurent G, Benzer S (2003) Painless, a Drosophila gene essential for nociception. Cell 113(2):261\u2013273. https:\/\/doi.org\/10.1016\/s0092-8674(03)00272-1","journal-title":"Cell"},{"issue":"3","key":"10529_CR62","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1111\/j.1743-6109.2010.02157.x","volume":"8","author":"AM Traish","year":"2011","unstructured":"Traish AM, Hassani J, Guay AT, Zitzmann M, Hansen ML (2011) Adverse side effects of 5alpha-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients. J Sex Med 8(3):872\u2013884. https:\/\/doi.org\/10.1111\/j.1743-6109.2010.02157.x","journal-title":"J Sex Med"},{"issue":"1","key":"10529_CR63","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1002\/smrj.3","volume":"1","author":"L Trost","year":"2013","unstructured":"Trost L, Saitz TR, Hellstrom WJ (2013) Side effects of 5-alpha reductase inhibitors: a comprehensive review. Sex Med Rev 1(1):24\u201341. https:\/\/doi.org\/10.1002\/smrj.3","journal-title":"Sex Med Rev"},{"issue":"6","key":"10529_CR64","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/s0090-4295(02)01971-4","volume":"60","author":"D Vaughan","year":"2002","unstructured":"Vaughan D, Imperato-McGinley J, McConnell J, Matsumoto AM, Bracken B, Roy J, Sullivan M, Pappas F, Cook T, Daurio C, Meehan A, Stoner E, Waldstreicher J (2002) Long-term (7 to 8-year) experience with finasteride in men with benign prostatic hyperplasia. Urology 60(6):1040\u20131044. https:\/\/doi.org\/10.1016\/s0090-4295(02)01971-4","journal-title":"Urology"},{"key":"10529_CR65","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.jes.2021.12.027","volume":"125","author":"Z Wang","year":"2023","unstructured":"Wang Z, Zhang L, Wang X (2023) Molecular toxicity and defense mechanisms induced by silver nanoparticles in Drosophila melanogaster. J Environ Sci (China) 125:616\u2013629. https:\/\/doi.org\/10.1016\/j.jes.2021.12.027","journal-title":"J Environ Sci (China)"},{"key":"10529_CR66","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-026-00903-1","author":"W Wang","year":"2026","unstructured":"Wang W, Wang S, Yuan Y, Rui M (2026) Ribbon constrains dendritic pruning via actin scaffolding and exocyst complex. Cell Mol Biol Lett. https:\/\/doi.org\/10.1186\/s11658-026-00903-1","journal-title":"Cell Mol Biol Lett"},{"issue":"5","key":"10529_CR67","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1001\/jamainternmed.2017.0089","volume":"177","author":"B Welk","year":"2017","unstructured":"Welk B, McArthur E, Ordon M, Anderson KK, Hayward J, Dixon S (2017) Association of suicidality and depression with 5alpha-reductase inhibitors. JAMA Intern Med 177(5):683\u2013691. https:\/\/doi.org\/10.1001\/jamainternmed.2017.0089","journal-title":"JAMA Intern Med"},{"issue":"7","key":"10529_CR68","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1523\/JNEUROSCI.4521-03.2004","volume":"24","author":"DW Williams","year":"2004","unstructured":"Williams DW, Truman JW (2004) Mechanisms of dendritic elaboration of sensory neurons in Drosophila: insights from in vivo time lapse. J Neurosci 24(7):1541\u20131550. https:\/\/doi.org\/10.1523\/JNEUROSCI.4521-03.2004","journal-title":"J Neurosci"},{"key":"10529_CR69","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112739","volume":"225","author":"Q Wu","year":"2021","unstructured":"Wu Q, Du X, Feng X, Cheng H, Chen Y, Lu C, Wu M, Tong H (2021) Chlordane exposure causes developmental delay and metabolic disorders in Drosophila melanogaster. Ecotoxicol Environ Saf 225:112739. https:\/\/doi.org\/10.1016\/j.ecoenv.2021.112739","journal-title":"Ecotoxicol Environ Saf"},{"key":"10529_CR70","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-7-10","volume":"7","author":"R Xia","year":"2012","unstructured":"Xia R, Liu Y, Yang L, Gal J, Zhu H, Jia J (2012) Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS. Mol Neurodegener 7:10. https:\/\/doi.org\/10.1186\/1750-1326-7-10","journal-title":"Mol Neurodegener"},{"issue":"1","key":"10529_CR71","doi-asserted-by":"publisher","first-page":"5430","DOI":"10.1038\/s41467-020-19249-z","volume":"11","author":"Q Xiao","year":"2020","unstructured":"Xiao Q, Wang L, Supekar S, Shen T, Liu H, Ye F, Zhang C (2020) Structure of human steroid 5alpha-reductase 2 with the anti-androgen drug finasteride. Nat Commun 11(1):5430. https:\/\/doi.org\/10.1038\/s41467-020-19249-z","journal-title":"Nat Commun"},{"key":"10529_CR72","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/978-1-0716-3969-6_5","volume":"2831","author":"Y Xu","year":"2024","unstructured":"Xu Y, Bush I, Han C (2024) Visualizing and measuring dendrite arborization in Drosophila somatosensory neurons. Methods Mol Biol 2831:59\u201371. https:\/\/doi.org\/10.1007\/978-1-0716-3969-6_5","journal-title":"Methods Mol Biol"},{"key":"10529_CR73","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-026-03026-4","author":"W Xu","year":"2026","unstructured":"Xu W, Wang S, Lv X, Long K, Mo K, Rui M (2026) Patronin facilitates neurite remodeling via epithelial-to-neuronal signaling. Cell Commun Signal. https:\/\/doi.org\/10.1186\/s12964-026-03026-4","journal-title":"Cell Commun Signal"},{"key":"10529_CR74","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1146\/annurev-ento-120811-153608","volume":"58","author":"N Yamanaka","year":"2013","unstructured":"Yamanaka N, Rewitz KF, O\u2019Connor MB (2013) Ecdysone control of developmental transitions: lessons from &lt;i&gt;Drosophila&lt;\/i&gt; research. Annu Rev Entomol 58:497\u2013516. https:\/\/doi.org\/10.1146\/annurev-ento-120811-153608","journal-title":"Annu Rev Entomol"},{"issue":"16","key":"10529_CR75","doi-asserted-by":"publisher","first-page":"5219","DOI":"10.1073\/pnas.1417838112","volume":"112","author":"Z Yang","year":"2015","unstructured":"Yang Z, Yu Y, Zhang V, Tian Y, Qi W, Wang L (2015) Octopamine mediates starvation-induced hyperactivity in adult Drosophila. Proc Natl Acad Sci U S A 112(16):5219\u20135224. https:\/\/doi.org\/10.1073\/pnas.1417838112","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10529_CR76","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124609","volume":"241","author":"S Yang","year":"2023","unstructured":"Yang S, Xiu M, Li X, Shi Y, Wang S, Wan S, Han S, Yang D, Liu Y, He J (2023) The antioxidant effects of hedysarum polybotrys polysaccharide in extending lifespan and ameliorating aging-related diseases in Drosophila melanogaster. Int J Biol Macromol 241:124609. https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.124609","journal-title":"Int J Biol Macromol"},{"issue":"16","key":"10529_CR77","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1016\/j.cub.2017.06.068","volume":"27","author":"J Yoshino","year":"2017","unstructured":"Yoshino J, Morikawa RK, Hasegawa E, Emoto K (2017) Neural circuitry that evokes escape behavior upon activation of nociceptive sensory neurons in Drosophila larvae. Curr Biol 27(16):2499-2504 e2493. https:\/\/doi.org\/10.1016\/j.cub.2017.06.068","journal-title":"Curr Biol"},{"key":"10529_CR78","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.164076","volume":"888","author":"X Zhang","year":"2023","unstructured":"Zhang X, Song Y, Wang J, Wu C, Xiang H, Hu J, Gong H, Sun M (2023) Chronic exposure to titanium dioxide nanoparticles induces deficits of locomotor behavior by disrupting the development of NMJ in Drosophila. Sci Total Environ 888:164076. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.164076","journal-title":"Sci Total Environ"},{"issue":"1","key":"10529_CR79","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00018-024-05560-1","volume":"82","author":"T Zheng","year":"2025","unstructured":"Zheng T, Long K, Wang S, Rui M (2025) Glial-derived TNF\/Eiger signaling promotes somatosensory neurite sculpting. Cell Mol Life Sci 82(1):47. https:\/\/doi.org\/10.1007\/s00018-024-05560-1","journal-title":"Cell Mol Life Sci"}],"container-title":["Biogerontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-026-10529-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10522-026-10529-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10522-026-10529-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:02:35Z","timestamp":1792256555000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10522-026-10529-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,17]]},"references-count":79,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10529"],"URL":"https:\/\/doi.org\/10.1007\/s10522-026-10529-7","relation":{},"ISSN":["1389-5729","1573-6768"],"issn-type":[{"value":"1389-5729","type":"print"},{"value":"1573-6768","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,17]]},"assertion":[{"value":"9 September 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing or financial interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"181"}}