{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T14:34:29Z","timestamp":1782225269845,"version":"3.54.5"},"reference-count":112,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T00:00:00Z","timestamp":1451433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Max Planck Society, Germany"},{"DOI":"10.13039\/501100005363","name":"University of Buenos Aires","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondo para la Convergencia Estructural del Mercosur"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1007\/s10528-015-9709-6","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T07:44:45Z","timestamp":1451461485000},"page":"107-119","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Molecular Mechanisms Underlying Pituitary Pathogenesis"],"prefix":"10.1007","volume":"54","author":[{"given":"Melanie","family":"Sapochnik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro Eduardo","family":"Nieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Fuertes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Arzt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"key":"9709_CR1","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1210\/me.2004-0403","volume":"19","author":"RA Abbud","year":"2005","unstructured":"Abbud RA, Takumi I, Barker EM, Ren SG, Chen DY, Wawrowsky K, Melmed S (2005) Early multipotential pituitary focal hyperplasia in the alpha-subunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice. Mol Endocrinol 19:1383\u20131391. doi: 10.1210\/me.2004-0403","journal-title":"Mol Endocrinol"},{"key":"9709_CR2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s11060-013-1354-5","volume":"117","author":"ED Aflorei","year":"2014","unstructured":"Aflorei ED, Korbonits M (2014) Epidemiology and etiopathogenesis of pituitary adenomas. J Neurooncol 117:379\u2013394. doi: 10.1007\/s11060-013-1354-5","journal-title":"J Neurooncol"},{"key":"9709_CR3","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/j.1750-3639.2001.tb00404.x","volume":"11","author":"JM Alexander","year":"2001","unstructured":"Alexander JM (2001) Tumor suppressor loss in pituitary tumors. Brain Pathol 11:342\u2013355","journal-title":"Brain Pathol"},{"key":"9709_CR4","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1172\/JCI114705","volume":"86","author":"JM Alexander","year":"1990","unstructured":"Alexander JM, Biller BM, Bikkal H, Zervas NT, Arnold A, Klibanski A (1990) Clinically nonfunctioning pituitary tumors are monoclonal in origin. J Clin Investig 86:336\u2013340. doi: 10.1172\/JCI114705","journal-title":"J Clin Investig"},{"key":"9709_CR5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.14310\/horm.2002.1358","volume":"11","author":"KI Alexandraki","year":"2012","unstructured":"Alexandraki KI, Munayem Khan M, Chahal HS, Dalantaeva NS, Trivellin G, Berney DM, Caron P, Popovic V, Pfeifer M, Jordan S, Korbonits M, Grossman AB (2012) Oncogene-induced senescence in pituitary adenomas and carcinomas. Hormones (Athens) 11:297\u2013307","journal-title":"Hormones (Athens)"},{"key":"9709_CR6","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1172\/JCI200114660","volume":"108","author":"E Arzt","year":"2001","unstructured":"Arzt E (2001) gp130 cytokine signaling in the pituitary gland: a paradigm for cytokine-neuro-endocrine pathways. J Clin Investig 108:1729\u20131733. doi: 10.1172\/JCI14660","journal-title":"J Clin Investig"},{"key":"9709_CR7","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1210\/endo.132.1.8419142","volume":"132","author":"E Arzt","year":"1993","unstructured":"Arzt E, Buric R, Stelzer G, Stalla J, Sauer J, Renner U, Stalla GK (1993) Interleukin involvement in anterior pituitary cell growth regulation: effects of IL-2 and IL-6. Endocrinology 132:459\u2013467. doi: 10.1210\/endo.132.1.8419142","journal-title":"Endocrinology"},{"key":"9709_CR8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/frne.1998.0176","volume":"20","author":"E Arzt","year":"1999","unstructured":"Arzt E, Pereda MP, Castro CP, Pagotto U, Renner U, Stalla GK (1999) Pathophysiological role of the cytokine network in the anterior pituitary gland. Front Neuroendocrinol 20:71\u201395. doi: 10.1006\/frne.1998.0176","journal-title":"Front Neuroendocrinol"},{"key":"9709_CR9","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4161\/cc.8.5.8065","volume":"8","author":"E Arzt","year":"2009","unstructured":"Arzt E, Chesnokova V, Stalla GK, Melmed S (2009) Pituitary adenoma growth: a model for cellular senescence and cytokine action. Cell Cycle 8:677\u2013678","journal-title":"Cell Cycle"},{"key":"9709_CR10","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nrc926","volume":"2","author":"SL Asa","year":"2002","unstructured":"Asa SL, Ezzat S (2002) The pathogenesis of pituitary tumours. Nat Rev Cancer 2:836\u2013849. doi: 10.1038\/nrc926","journal-title":"Nat Rev Cancer"},{"key":"9709_CR11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev.pathol.4.110807.092259","volume":"4","author":"SL Asa","year":"2009","unstructured":"Asa SL, Ezzat S (2009) The pathogenesis of pituitary tumors. Annu Rev Pathol 4:97\u2013126. doi: 10.1146\/annurev.pathol.4.110807.092259","journal-title":"Annu Rev Pathol"},{"key":"9709_CR12","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.1210\/jc.2002-022044","volume":"88","author":"SA Borg","year":"2003","unstructured":"Borg SA, Kerry KE, Baxter L, Royds JA, Jones TH (2003) Expression of interleukin-6 and its effects on growth of HP75 human pituitary tumor cells. J Clin Endocrinol Metab 88:4938\u20134944. doi: 10.1210\/jc.2002-022044","journal-title":"J Clin Endocrinol Metab"},{"key":"9709_CR13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/jcp.20282","volume":"204","author":"A Bottoni","year":"2005","unstructured":"Bottoni A, Piccin D, Tagliati F, Luchin A, Zatelli MC, Degli Uberti EC (2005) miR-15a and miR-16-1 down-regulation in pituitary adenomas. J Cell Physiol 204:280\u2013285. doi: 10.1002\/jcp.20282","journal-title":"J Cell Physiol"},{"key":"9709_CR14","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/jcp.20832","volume":"210","author":"A Bottoni","year":"2007","unstructured":"Bottoni A, Zatelli MC, Ferracin M, Tagliati F, Piccin D, Vignali C, Calin GA, Negrini M, Croce CM, Degli Uberti EC (2007) Identification of differentially expressed microRNAs by microarray: a possible role for microRNA genes in pituitary adenomas. J Cell Physiol 210:370\u2013377. doi: 10.1002\/jcp.20832","journal-title":"J Cell Physiol"},{"key":"9709_CR15","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature03841","volume":"436","author":"M Braig","year":"2005","unstructured":"Braig M, Lee S, Loddenkemper C, Rudolph C, Peters AH, Schlegelberger B, Stein H, Dorken B, Jenuwein T, Schmitt CA (2005) Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436:660\u2013665. doi: 10.1038\/nature03841","journal-title":"Nature"},{"key":"9709_CR16","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1210\/jcem.86.12.8070","volume":"86","author":"ML Brandi","year":"2001","unstructured":"Brandi ML, Gagel RF, Angeli A, Bilezikian JP, Beck-Peccoz P, Bordi C, Conte-Devolx B, Falchetti A, Gheri RG, Libroia A, Lips CJ, Lombardi G, Mannelli M, Pacini F, Ponder BA, Raue F, Skogseid B, Tamburrano G, Thakker RV, Thompson NW, Tomassetti P, Tonelli F, Wells SA Jr, Marx SJ (2001) Guidelines for diagnosis and therapy of MEN type 1 and type 2. J Clin Endocrinol Metab 86:5658\u20135671. doi: 10.1210\/jcem.86.12.8070","journal-title":"J Clin Endocrinol Metab"},{"key":"9709_CR17","doi-asserted-by":"crossref","first-page":"15524","DOI":"10.1073\/pnas.242606799","volume":"99","author":"GA Calin","year":"2002","unstructured":"Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM (2002) Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 99:15524\u201315529. doi: 10.1073\/pnas.242606799","journal-title":"Proc Natl Acad Sci USA"},{"key":"9709_CR18","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/S0962-8924(01)82148-6","volume":"11","author":"J Campisi","year":"2001","unstructured":"Campisi J (2001) Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol 11:S27\u2013S31","journal-title":"Trends Cell Biol"},{"key":"9709_CR19","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cell.2005.02.003","volume":"120","author":"J Campisi","year":"2005","unstructured":"Campisi J (2005) Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120:513\u2013522. doi: 10.1016\/j.cell.2005.02.003","journal-title":"Cell"},{"key":"9709_CR20","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1210\/en.2002-220891","volume":"144","author":"CP Castro","year":"2003","unstructured":"Castro CP, Giacomini D, Nagashima AC, Onofri C, Graciarena M, Kobayashi K, Paez-Pereda M, Renner U, Stalla GK, Arzt E (2003) Reduced expression of the cytokine transducer gp130 inhibits hormone secretion, cell growth, and tumor development of pituitary lactosomatotrophic GH3 cells. Endocrinology 144:693\u2013700. doi: 10.1210\/en.2002-220891","journal-title":"Endocrinology"},{"key":"9709_CR21","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature03918","volume":"436","author":"Z Chen","year":"2005","unstructured":"Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M, Koutcher JA, Scher HI, Ludwig T, Gerald W, Cordon-Cardo C, Pandolfi PP (2005) Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436:725\u2013730. doi: 10.1038\/nature03918","journal-title":"Nature"},{"key":"9709_CR22","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1210\/me.2005-0137","volume":"19","author":"V Chesnokova","year":"2005","unstructured":"Chesnokova V, Kovacs K, Castro AV, Zonis S, Melmed S (2005) Pituitary hypoplasia in Pttg\u2212\/\u2212 mice is protective for Rb+\/\u2212 pituitary tumorigenesis. Mol Endocrinol 19:2371\u20132379. doi: 10.1210\/me.2005-0137","journal-title":"Mol Endocrinol"},{"key":"9709_CR23","doi-asserted-by":"crossref","first-page":"10564","DOI":"10.1158\/0008-5472.CAN-07-0974","volume":"67","author":"V Chesnokova","year":"2007","unstructured":"Chesnokova V, Zonis S, Rubinek T, Yu R, Ben-Shlomo A, Kovacs K, Wawrowsky K, Melmed S (2007) Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth. Cancer Res 67:10564\u201310572. doi: 10.1158\/0008-5472.CAN-07-0974","journal-title":"Cancer Res"},{"key":"9709_CR24","doi-asserted-by":"crossref","first-page":"17498","DOI":"10.1073\/pnas.0804810105","volume":"105","author":"V Chesnokova","year":"2008","unstructured":"Chesnokova V, Zonis S, Kovacs K, Ben-Shlomo A, Wawrowsky K, Bannykh S, Melmed S (2008) p21(Cip1) restrains pituitary tumor growth. Proc Natl Acad Sci USA 105:17498\u201317503. doi: 10.1073\/pnas.0804810105","journal-title":"Proc Natl Acad Sci USA"},{"key":"9709_CR25","doi-asserted-by":"crossref","first-page":"e17924","DOI":"10.1371\/journal.pone.0017924","volume":"6","author":"V Chesnokova","year":"2011","unstructured":"Chesnokova V, Zonis S, Zhou C, Ben-Shlomo A, Wawrowsky K, Toledano Y, Tong Y, Kovacs K, Scheithauer B, Melmed S (2011) Lineage-specific restraint of pituitary gonadotroph cell adenoma growth. PLoS One 6:e17924. doi: 10.1371\/journal.pone.0017924","journal-title":"PLoS One"},{"key":"9709_CR26","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.cell.2008.05.027","volume":"133","author":"K Cichowski","year":"2008","unstructured":"Cichowski K, Hahn WC (2008) Unexpected pieces to the senescence puzzle. Cell 133:958\u2013961. doi: 10.1016\/j.cell.2008.05.027","journal-title":"Cell"},{"key":"9709_CR27","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000079045","volume":"32","author":"RN Clayton","year":"2004","unstructured":"Clayton RN, Farrell WE (2004) Pituitary tumour clonality revisited. Front Horm Res 32:186\u2013204","journal-title":"Front Horm Res"},{"key":"9709_CR28","first-page":"3973","volume":"6","author":"RN Clayton","year":"2000","unstructured":"Clayton RN, Pfeifer M, Atkinson AB, Belchetz P, Wass JA, Kyrodimou E, Vanderpump M, Simpson D, Bicknell J, Farrell WE (2000) Different patterns of allelic loss (loss of heterozygosity) in recurrent human pituitary tumors provide evidence for multiclonal origins. Clin Cancer Res 6:3973\u20133982","journal-title":"Clin Cancer Res"},{"key":"9709_CR29","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000318499","volume":"38","author":"A Colao","year":"2010","unstructured":"Colao A, Ochoa AS, Auriemma RS, Faggiano A, Pivonello R, Lombardi G (2010) Pituitary carcinomas. Front Horm Res 38:94\u2013108. doi: 10.1159\/000318499","journal-title":"Front Horm Res"},{"key":"9709_CR30","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/436642a","volume":"436","author":"M Collado","year":"2005","unstructured":"Collado M, Gil J, Efeyan A, Guerra C, Schuhmacher AJ, Barradas M, Benguria A, Zaballos A, Flores JM, Barbacid M, Beach D, Serrano M (2005) Tumour biology: senescence in premalignant tumours. Nature 436:642. doi: 10.1038\/436642a","journal-title":"Nature"},{"key":"9709_CR31","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cell.2007.07.003","volume":"130","author":"M Collado","year":"2007","unstructured":"Collado M, Blasco MA, Serrano M (2007) Cellular senescence in cancer and aging. Cell 130:223\u2013233. doi: 10.1016\/j.cell.2007.07.003","journal-title":"Cell"},{"key":"9709_CR32","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ccr.2006.10.003","volume":"10","author":"S Courtois-Cox","year":"2006","unstructured":"Courtois-Cox S, Genther Williams SM, Reczek EE, Johnson BW, McGillicuddy LT, Johannessen CM, Hollstein PE, MacCollin M, Cichowski K (2006) A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell 10:459\u2013472. doi: 10.1016\/j.ccr.2006.10.003","journal-title":"Cancer Cell"},{"key":"9709_CR33","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nrg2634","volume":"10","author":"CM Croce","year":"2009","unstructured":"Croce CM (2009) Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet 10:704\u2013714. doi: 10.1038\/nrg2634","journal-title":"Nat Rev Genet"},{"key":"9709_CR34","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1210\/jc.2006-1668","volume":"91","author":"AF Daly","year":"2006","unstructured":"Daly AF, Rixhon M, Adam C, Dempegioti A, Tichomirowa MA, Beckers A (2006) High prevalence of pituitary adenomas: a cross-sectional study in the province of Liege, Belgium. J Clin Endocrinol Metab 91:4769\u20134775. doi: 10.1210\/jc.2006-1668","journal-title":"J Clin Endocrinol Metab"},{"key":"9709_CR35","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.beem.2009.05.008","volume":"23","author":"AF Daly","year":"2009","unstructured":"Daly AF, Tichomirowa MA, Beckers A (2009) The epidemiology and genetics of pituitary adenomas. Best Pract Res Clin Endocrinol Metab 23:543\u2013554. doi: 10.1016\/j.beem.2009.05.008","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"9709_CR36","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1101\/gad.1516407","volume":"21","author":"D Dankort","year":"2007","unstructured":"Dankort D, Filenova E, Collado M, Serrano M, Jones K, McMahon M (2007) A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes Dev 21:379\u2013384. doi: 10.1101\/gad.1516407","journal-title":"Genes Dev"},{"key":"9709_CR37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cell.2012.06.013","volume":"150","author":"MA Dawson","year":"2012","unstructured":"Dawson MA, Kouzarides T (2012) Cancer epigenetics: from mechanism to therapy. Cell 150:12\u201327. doi: 10.1016\/j.cell.2012.06.013","journal-title":"Cell"},{"key":"9709_CR38","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.4161\/cc.7.17.6597","volume":"7","author":"S Deng","year":"2008","unstructured":"Deng S, Calin GA, Croce CM, Coukos G, Zhang L (2008) Mechanisms of microRNA deregulation in human cancer. Cell Cycle 7:2643\u20132646","journal-title":"Cell Cycle"},{"key":"9709_CR39","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrendo.2014.64","volume":"10","author":"A Ieva Di","year":"2014","unstructured":"Di Ieva A, Rotondo F, Syro LV, Cusimano MD, Kovacs K (2014) Aggressive pituitary adenomas\u2013diagnosis and emerging treatments. Nat Rev Endocrinol 10:423\u2013435. doi: 10.1038\/nrendo.2014.64","journal-title":"Nat Rev Endocrinol"},{"key":"9709_CR40","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","volume":"92","author":"GP Dimri","year":"1995","unstructured":"Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O et al (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92:9363\u20139367","journal-title":"Proc Natl Acad Sci USA"},{"key":"9709_CR41","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.1210\/en.2006-0544","volume":"147","author":"I Donangelo","year":"2006","unstructured":"Donangelo I, Gutman S, Horvath E, Kovacs K, Wawrowsky K, Mount M, Melmed S (2006) Pituitary tumor transforming gene overexpression facilitates pituitary tumor development. Endocrinology 147:4781\u20134791. doi: 10.1210\/en.2006-0544","journal-title":"Endocrinology"},{"key":"9709_CR42","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.beem.2009.05.004","volume":"23","author":"D Dworakowska","year":"2009","unstructured":"Dworakowska D, Grossman AB (2009) The pathophysiology of pituitary adenomas. Best Pract Res Clin Endocrinol Metab 23:525\u2013541. doi: 10.1016\/j.beem.2009.05.004","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"9709_CR43","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrendo.2009.126","volume":"5","author":"MS Elston","year":"2009","unstructured":"Elston MS, McDonald KL, Clifton-Bligh RJ, Robinson BG (2009) Familial pituitary tumor syndromes. Nat Rev Endocrinol 5:453\u2013461. doi: 10.1038\/nrendo.2009.126","journal-title":"Nat Rev Endocrinol"},{"key":"9709_CR44","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF00197396","volume":"424","author":"MR Farnoud","year":"1994","unstructured":"Farnoud MR, Kujas M, Derome P, Racadot J, Peillon F, Li JY (1994) Interactions between normal and tumoral tissues at the boundary of human anterior pituitary adenomas. An immunohistochemical study. Virchows Arch 424:75\u201382","journal-title":"Virchows Arch"},{"key":"9709_CR45","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1055\/s-2005-870153","volume":"37","author":"WE Farrell","year":"2005","unstructured":"Farrell WE (2005) Epigenetic mechanisms of tumorigenesis. Horm Metab Res 37:361\u2013368. doi: 10.1055\/s-2005-870153","journal-title":"Horm Metab Res"},{"key":"9709_CR46","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1677\/erc.1.01131","volume":"13","author":"WE Farrell","year":"2006","unstructured":"Farrell WE (2006) Pituitary tumours: findings from whole genome analyses. Endocr Relat Cancer 13:707\u2013716. doi: 10.1677\/erc.1.01131","journal-title":"Endocr Relat Cancer"},{"key":"9709_CR47","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1677\/erc.0.0100323","volume":"10","author":"WE Farrell","year":"2003","unstructured":"Farrell WE, Clayton RN (2003) Epigenetic change in pituitary tumorigenesis. Endocr Relat Cancer 10:323\u2013330","journal-title":"Endocr Relat Cancer"},{"key":"9709_CR48","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1677\/JME-09-0178","volume":"44","author":"M Fedele","year":"2010","unstructured":"Fedele M, Fusco A (2010) Role of the high mobility group A proteins in the regulation of pituitary cell cycle. J Mol Endocrinol 44:309\u2013318. doi: 10.1677\/JME-09-0178","journal-title":"J Mol Endocrinol"},{"key":"9709_CR49","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-2265.2009.03667.x","volume":"72","author":"A Fernandez","year":"2010","unstructured":"Fernandez A, Karavitaki N, Wass JA (2010) Prevalence of pituitary adenomas: a community-based, cross-sectional study in Banbury (Oxfordshire, UK). Clin Endocrinol (Oxf) 72:377\u2013382. doi: 10.1111\/j.1365-2265.2009.03667.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"9709_CR50","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1365-2265.2006.02630.x","volume":"65","author":"M Filippella","year":"2006","unstructured":"Filippella M, Galland F, Kujas M, Young J, Faggiano A, Lombardi G, Colao A, Meduri G, Chanson P (2006) Pituitary tumour transforming gene (PTTG) expression correlates with the proliferative activity and recurrence status of pituitary adenomas: a clinical and immunohistochemical study. Clin Endocrinol (Oxf) 65:536\u2013543. doi: 10.1111\/j.1365-2265.2006.02630.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"9709_CR51","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1677\/joe.0.1600483","volume":"160","author":"J Gloddek","year":"1999","unstructured":"Gloddek J, Pagotto U, Paez Pereda M, Arzt E, Stalla GK, Renner U (1999) Pituitary adenylate cyclase-activating polypeptide, interleukin-6 and glucocorticoids regulate the release of vascular endothelial growth factor in pituitary folliculostellate cells. J Endocrinol 160:483\u2013490","journal-title":"J Endocrinol"},{"key":"9709_CR52","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/sj.bjc.6603283","volume":"95","author":"VC Gray-Schopfer","year":"2006","unstructured":"Gray-Schopfer VC, Cheong SC, Chong H, Chow J, Moss T, Abdel-Malek ZA, Marais R, Wynford-Thomas D, Bennett DC (2006) Cellular senescence in naevi and immortalisation in melanoma: a role for p16? Br J Cancer 95:496\u2013505. doi: 10.1038\/sj.bjc.6603283","journal-title":"Br J Cancer"},{"key":"9709_CR53","doi-asserted-by":"crossref","first-page":"10968","DOI":"10.1073\/pnas.0611638104","volume":"104","author":"L Ha","year":"2007","unstructured":"Ha L, Ichikawa T, Anver M, Dickins R, Lowe S, Sharpless NE, Krimpenfort P, Depinho RA, Bennett DC, Sviderskaya EV, Merlino G (2007) ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence. Proc Natl Acad Sci USA 104:10968\u201310973. doi: 10.1073\/pnas.0611638104","journal-title":"Proc Natl Acad Sci USA"},{"key":"9709_CR54","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646\u2013674. doi: 10.1016\/j.cell.2011.02.013","journal-title":"Cell"},{"key":"9709_CR55","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1210\/jcem.85.11.7122","volume":"85","author":"A Hanisch","year":"2000","unstructured":"Hanisch A, Dieterich KD, Dietzmann K, Ludecke K, Buchfelder M, Fahlbusch R, Lehnert H (2000) Expression of members of the interleukin-6 family of cytokines and their receptors in human pituitary and pituitary adenomas. J Clin Endocrinol Metab 85:4411\u20134414. doi: 10.1210\/jcem.85.11.7122","journal-title":"J Clin Endocrinol Metab"},{"key":"9709_CR57","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/15275","volume":"5","author":"AP Heaney","year":"1999","unstructured":"Heaney AP, Horwitz GA, Wang Z, Singson R, Melmed S (1999) Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis. Nat Med 5:1317\u20131321. doi: 10.1038\/15275","journal-title":"Nat Med"},{"key":"9709_CR58","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1210\/jcem-71-6-1427","volume":"71","author":"V Herman","year":"1990","unstructured":"Herman V, Fagin J, Gonsky R, Kovacs K, Melmed S (1990) Clonal origin of pituitary adenomas. J Clin Endocrinol Metab 71:1427\u20131433. doi: 10.1210\/jcem-71-6-1427","journal-title":"J Clin Endocrinol Metab"},{"key":"9709_CR59","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF00689825","volume":"65","author":"H Hofler","year":"1984","unstructured":"Hofler H, Walter GF, Denk H (1984) Immunohistochemistry of folliculo-stellate cells in normal human adenohypophyses and in pituitary adenomas. Acta Neuropathol 65:35\u201340","journal-title":"Acta Neuropathol"},{"key":"9709_CR60","first-page":"867","volume":"86","author":"H Ishikawa","year":"2001","unstructured":"Ishikawa H, Heaney AP, Yu R, Horwitz GA, Melmed S (2001) Human pituitary tumor-transforming gene induces angiogenesis. J Clin Endocrinol Metab 86:867\u2013874. doi: 10.1210\/jcem.86.2.7184","journal-title":"J Clin Endocrinol Metab"},{"key":"9709_CR61","first-page":"180","volume":"78","author":"TH Jones","year":"1994","unstructured":"Jones TH, Daniels M, James RA, Justice SK, McCorkle R, Price A, Kendall-Taylor P, Weetman AP (1994) Production of bioactive and immunoreactive interleukin-6 (IL-6) and expression of IL-6 messenger ribonucleic acid by human pituitary adenomas. J Clin Endocrinol Metab 78:180\u2013187. doi: 10.1210\/jcem.78.1.8288702","journal-title":"J Clin Endocrinol Metab"},{"key":"9709_CR63","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.1038\/sj.onc.1208659","volume":"24","author":"D Kim","year":"2005","unstructured":"Kim D, Pemberton H, Stratford AL, Buelaert K, Watkinson JC, Lopes V, Franklyn JA, McCabe CJ (2005) Pituitary tumour transforming gene (PTTG) induces genetic instability in thyroid cells. Oncogene 24:4861\u20134866. doi: 10.1038\/sj.onc.1208659","journal-title":"Oncogene"},{"key":"9709_CR64","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/carcin\/bgl202","volume":"28","author":"DS Kim","year":"2007","unstructured":"Kim DS, Franklyn JA, Smith VE, Stratford AL, Pemberton HN, Warfield A, Watkinson JC, Ishmail T, Wakelam MJ, McCabe CJ (2007) Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity. Carcinogenesis 28:749\u2013759. doi: 10.1093\/carcin\/bgl202","journal-title":"Carcinogenesis"},{"key":"9709_CR65","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/gcc.20621","volume":"48","author":"M Kirsch","year":"2009","unstructured":"Kirsch M, Morz M, Pinzer T, Schackert HK, Schackert G (2009) Frequent loss of the CDKN2C (p18INK4c) gene product in pituitary adenomas. Genes Chromosomes Cancer 48:143\u2013154. doi: 10.1002\/gcc.20621","journal-title":"Genes Chromosomes Cancer"},{"key":"9709_CR66","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/sj.embor.7400452","volume":"6","author":"E Lazzerini Denchi","year":"2005","unstructured":"Lazzerini Denchi E, Helin K (2005) E2F1 is crucial for E2F-dependent apoptosis. EMBO Rep 6:661\u2013668. doi: 10.1038\/sj.embor.7400452","journal-title":"EMBO Rep"},{"key":"9709_CR67","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0091-3022(03)00012-8","volume":"24","author":"A Levy","year":"2003","unstructured":"Levy A, Lightman S (2003) Molecular defects in the pathogenesis of pituitary tumours. Front Neuroendocrinol 24:94\u2013127","journal-title":"Front Neuroendocrinol"},{"key":"9709_CR68","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S1470-2045(12)70102-X","volume":"13","author":"N Liu","year":"2012","unstructured":"Liu N, Chen NY, Cui RX, Li WF, Li Y, Wei RR, Zhang MY, Sun Y, Huang BJ, Chen M, He QM, Jiang N, Chen L, Cho WC, Yun JP, Zeng J, Liu LZ, Li L, Guo Y, Wang HY, Ma J (2012) Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis. Lancet Oncol 13:633\u2013641. doi: 10.1016\/S1470-2045(12)70102-X","journal-title":"Lancet Oncol"},{"key":"9709_CR69","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1746-1596-5-79","volume":"5","author":"ZG Mao","year":"2010","unstructured":"Mao ZG, He DS, Zhou J, Yao B, Xiao WW, Chen CH, Zhu YH, Wang HJ (2010) Differential expression of microRNAs in GH-secreting pituitary adenomas. Diagn Pathol 5:79. doi: 10.1186\/1746-1596-5-79","journal-title":"Diagn Pathol"},{"key":"9709_CR70","first-page":"397","volume":"54","author":"SJ Marx","year":"1999","unstructured":"Marx SJ, Agarwal SK, Kester MB, Heppner C, Kim YS, Skarulis MC, James LA, Goldsmith PK, Saggar SK, Park SY, Spiegel AM, Burns AL, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Emmert-Buck MR, Guru SC, Manickam P, Crabtree J, Erdos MR, Collins FS, Chandrasekharappa SC (1999) Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias. Recent Prog Horm Res 54:397\u2013438 (discussion 438-399)","journal-title":"Recent Prog Horm Res"},{"key":"9709_CR71","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0889-8529(18)30117-8","volume":"23","author":"S Melmed","year":"1994","unstructured":"Melmed S (1994) Pituitary neoplasia. Endocrinol Metab Clin North Am 23:81\u201392","journal-title":"Endocrinol Metab Clin North Am"},{"key":"9709_CR72","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1172\/JCI20401","volume":"112","author":"S Melmed","year":"2003","unstructured":"Melmed S (2003) Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Investig 112:1603\u20131618. doi: 10.1172\/JCI20401","journal-title":"J Clin Investig"},{"key":"9709_CR73","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nrendo.2011.40","volume":"7","author":"S Melmed","year":"2011","unstructured":"Melmed S (2011) Pathogenesis of pituitary tumors. Nat Rev Endocrinol 7:257\u2013266. doi: 10.1038\/nrendo.2011.40","journal-title":"Nat Rev Endocrinol"},{"key":"9709_CR74","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nature03890","volume":"436","author":"C Michaloglou","year":"2005","unstructured":"Michaloglou C, Vredeveld LC, Soengas MS, Denoyelle C, Kuilman T, van der Horst CM, Majoor DM, Shay JW, Mooi WJ, Peeper DS (2005) BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436:720\u2013724. doi: 10.1038\/nature03890","journal-title":"Nature"},{"key":"9709_CR75","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1056\/NEJMra062285","volume":"355","author":"WJ Mooi","year":"2006","unstructured":"Mooi WJ, Peeper DS (2006) Oncogene-induced cell senescence\u2013halting on the road to cancer. N Engl J Med 355:1037\u20131046. doi: 10.1056\/NEJMra062285","journal-title":"N Engl J Med"},{"key":"9709_CR76","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.ejso.2011.05.005","volume":"37","author":"M Nugent","year":"2011","unstructured":"Nugent M, Miller N, Kerin MJ (2011) MicroRNAs in colorectal cancer: function, dysregulation and potential as novel biomarkers. Eur J Surg Oncol 37:649\u2013654. doi: 10.1016\/j.ejso.2011.05.005","journal-title":"Eur J Surg Oncol"},{"key":"9709_CR77","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/jnen\/64.5.398","volume":"64","author":"A Ogino","year":"2005","unstructured":"Ogino A, Yoshino A, Katayama Y, Watanabe T, Ota T, Komine C, Yokoyama T, Fukushima T (2005) The p15(INK4b)\/p16(INK4a)\/RB1 pathway is frequently deregulated in human pituitary adenomas. J Neuropathol Exp Neurol 64:398\u2013403","journal-title":"J Neuropathol Exp Neurol"},{"key":"9709_CR78","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2174\/1568008054863817","volume":"5","author":"M Paez-Pereda","year":"2005","unstructured":"Paez-Pereda M, Giacomini D, Echenique C, Stalla GK, Holsboer F, Arzt E (2005) Signaling processes in tumoral neuroendocrine pituitary cells as potential targets for therapeutic drugs. Curr Drug Targets Immune Endocr Metab Disord 5:259\u2013267","journal-title":"Curr Drug Targets Immune Endocr Metab Disord"},{"key":"9709_CR79","doi-asserted-by":"crossref","first-page":"e82619","DOI":"10.1371\/journal.pone.0082619","volume":"8","author":"M Pease","year":"2013","unstructured":"Pease M, Ling C, Mack WJ, Wang K, Zada G (2013) The role of epigenetic modification in tumorigenesis and progression of pituitary adenomas: a systematic review of the literature. PLoS One 8:e82619. doi: 10.1371\/journal.pone.0082619","journal-title":"PLoS One"},{"key":"9709_CR80","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1210\/mend.11.4.9911","volume":"11","author":"L Pei","year":"1997","unstructured":"Pei L, Melmed S (1997) Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol Endocrinol 11:433\u2013441. doi: 10.1210\/mend.11.4.9911","journal-title":"Mol Endocrinol"},{"key":"9709_CR81","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.yexcr.2011.12.001","volume":"318","author":"P Peltomaki","year":"2012","unstructured":"Peltomaki P (2012) Mutations and epimutations in the origin of cancer. Exp Cell Res 318:299\u2013310. doi: 10.1016\/j.yexcr.2011.12.001","journal-title":"Exp Cell Res"},{"key":"9709_CR82","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0303-7207(96)03924-X","volume":"124","author":"MP Pereda","year":"1996","unstructured":"Pereda MP, Goldberg V, Chervin A, Carrizo G, Molina A, Andrada J, Sauer J, Renner U, Stalla GK, Arzt E (1996) Interleukin-2 (IL-2) and IL-6 regulate c-fos protooncogene expression in human pituitary adenoma explants. Mol Cell Endocrinol 124:33\u201342","journal-title":"Mol Cell Endocrinol"},{"key":"9709_CR83","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1210\/endo.141.5.7442","volume":"141","author":"C Perez Castro","year":"2000","unstructured":"Perez Castro C, Nagashima AC, Pereda MP, Goldberg V, Chervin A, Largen P, Renner U, Stalla GK, Arzt E (2000) The gp130 cytokines interleukin-11 and ciliary neurotropic factor regulate through specific receptors the function and growth of lactosomatotropic and folliculostellate pituitary cell lines. Endocrinology 141:1746\u20131753. doi: 10.1210\/endo.141.5.7442","journal-title":"Endocrinology"},{"key":"9709_CR84","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1677\/joe.0.1690539","volume":"169","author":"C Perez Castro","year":"2001","unstructured":"Perez Castro C, Carbia Nagashima A, Paez Pereda M, Goldberg V, Chervin A, Carrizo G, Molina H, Renner U, Stalla GK, Arzt E (2001) Effects of the gp130 cytokines ciliary neurotropic factor (CNTF) and interleukin-11 on pituitary cells: CNTF receptors on human pituitary adenomas and stimulation of prolactin and GH secretion in normal rat anterior pituitary aggregate cultures. J Endocrinol 169:539\u2013547","journal-title":"J Endocrinol"},{"key":"9709_CR85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.00003.2011","volume":"92","author":"C Perez-Castro","year":"2012","unstructured":"Perez-Castro C, Renner U, Haedo MR, Stalla GK, Arzt E (2012) Cellular and molecular specificity of pituitary gland physiology. Physiol Rev 92:1\u201338. doi: 10.1152\/physrev.00003.2011","journal-title":"Physiol Rev"},{"key":"9709_CR86","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1677\/JME-08-0146","volume":"42","author":"V Quereda","year":"2009","unstructured":"Quereda V, Malumbres M (2009) Cell cycle control of pituitary development and disease. J Mol Endocrinol 42:75\u201386. doi: 10.1677\/JME-08-0146","journal-title":"J Mol Endocrinol"},{"key":"9709_CR87","doi-asserted-by":"crossref","first-page":"4268","DOI":"10.1210\/jc.2010-0537","volume":"95","author":"A Raappana","year":"2010","unstructured":"Raappana A, Koivukangas J, Ebeling T, Pirila T (2010) Incidence of pituitary adenomas in Northern Finland in 1992-2007. J Clin Endocrinol Metab 95:4268\u20134275. doi: 10.1210\/jc.2010-0537","journal-title":"J Clin Endocrinol Metab"},{"key":"9709_CR89","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ng1060","volume":"33","author":"S Ramaswamy","year":"2003","unstructured":"Ramaswamy S, Ross KN, Lander ES, Golub TR (2003) A molecular signature of metastasis in primary solid tumors. Nat Genet 33:49\u201354. doi: 10.1038\/ng1060","journal-title":"Nat Genet"},{"key":"9709_CR90","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1210\/edrv.18.2.0297","volume":"18","author":"D Ray","year":"1997","unstructured":"Ray D, Melmed S (1997) Pituitary cytokine and growth factor expression and action. Endocr Rev 18:206\u2013228. doi: 10.1210\/edrv.18.2.0297","journal-title":"Endocr Rev"},{"key":"9709_CR91","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1530\/eje.0.1350515","volume":"135","author":"U Renner","year":"1996","unstructured":"Renner U, Pagotto U, Arzt E, Stalla GK (1996) Autocrine and paracrine roles of polypeptide growth factors, cytokines and vasogenic substances in normal and tumorous pituitary function and growth: a review. Eur J Endocrinol 135:515\u2013532","journal-title":"Eur J Endocrinol"},{"key":"9709_CR92","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1055\/s-0029-1211777","volume":"105","author":"U Renner","year":"1997","unstructured":"Renner U, Gloddek J, Arzt E, Inoue K, Stalla GK (1997) Interleukin-6 is an autocrine growth factor for folliculostellate-like TtT\/GF mouse pituitary tumor cells. Exp Clin Endocrinol Diabetes 105:345\u2013352. doi: 10.1055\/s-0029-1211777","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"9709_CR93","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0739-7240(98)00027-7","volume":"15","author":"U Renner","year":"1998","unstructured":"Renner U, Gloddek J, Pereda MP, Arzt E, Stalla GK (1998) Regulation and role of intrapituitary IL-6 production by folliculostellate cells. Domest Anim Endocrinol 15:353\u2013362","journal-title":"Domest Anim Endocrinol"},{"key":"9709_CR94","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000079039","volume":"32","author":"U Renner","year":"2004","unstructured":"Renner U, Paez-Pereda M, Arzt E, Stalla GK (2004) Growth factors and cytokines: function and molecular regulation in pituitary adenomas. Front Horm Res 32:96\u2013109","journal-title":"Front Horm Res"},{"key":"9709_CR95","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1038\/sj.onc.1202914","volume":"18","author":"C Saez","year":"1999","unstructured":"Saez C, Japon MA, Ramos-Morales F, Romero F, Segura DI, Tortolero M, Pintor-Toro JA (1999) hpttg is over-expressed in pituitary adenomas and other primary epithelial neoplasias. Oncogene 18:5473\u20135476. doi: 10.1038\/sj.onc.1202914","journal-title":"Oncogene"},{"key":"9709_CR96","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1677\/ERC-08-0012","volume":"15","author":"F Salehi","year":"2008","unstructured":"Salehi F, Kovacs K, Scheithauer BW, Lloyd RV, Cusimano M (2008) Pituitary tumor-transforming gene in endocrine and other neoplasms: a review and update. Endocr Relat Cancer 15:721\u2013743. doi: 10.1677\/ERC-08-0012","journal-title":"Endocr Relat Cancer"},{"key":"9709_CR97","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1227\/01.NEU.0000223437.51435.6E","volume":"59","author":"BW Scheithauer","year":"2006","unstructured":"Scheithauer BW, Gaffey TA, Lloyd RV, Sebo TJ, Kovacs KT, Horvath E, Yapicier O, Young WF Jr, Meyer FB, Kuroki T, Riehle DL, Laws ER Jr (2006) Pathobiology of pituitary adenomas and carcinomas. Neurosurgery 59:341\u2013353. doi: 10.1227\/01.NEU.0000223437.51435.6E (discussion 341-353)","journal-title":"Neurosurgery"},{"key":"9709_CR98","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0092-8674(02)00734-1","volume":"109","author":"CA Schmitt","year":"2002","unstructured":"Schmitt CA, Fridman JS, Yang M, Lee S, Baranov E, Hoffman RM, Lowe SW (2002) A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 109:335\u2013346","journal-title":"Cell"},{"key":"9709_CR99","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S0955-0674(00)00278-7","volume":"13","author":"M Serrano","year":"2001","unstructured":"Serrano M, Blasco MA (2001) Putting the stress on senescence. Curr Opin Cell Biol 13:748\u2013753","journal-title":"Curr Opin Cell Biol"},{"key":"9709_CR100","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.mce.2009.12.028","volume":"326","author":"T Tateno","year":"2010","unstructured":"Tateno T, Zhu X, Asa SL, Ezzat S (2010) Chromatin remodeling and histone modifications in pituitary tumors. Mol Cell Endocrinol 326:66\u201370. doi: 10.1016\/j.mce.2009.12.028","journal-title":"Mol Cell Endocrinol"},{"key":"9709_CR101","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1365-2826.1995.tb00783.x","volume":"7","author":"Y Ueta","year":"1995","unstructured":"Ueta Y, Levy A, Chowdrey HS, Lightman SL (1995) S-100 antigen-positive folliculostellate cells are not the source of IL-6 gene expression in human pituitary adenomas. J Neuroendocrinol 7:467\u2013474","journal-title":"J Neuroendocrinol"},{"key":"9709_CR102","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1746-1596-2-20","volume":"2","author":"I Vajtai","year":"2007","unstructured":"Vajtai I, Kappeler A, Sahli R (2007) Folliculo-stellate cells of \u201ctrue dendritic\u201d type are involved in the inflammatory microenvironment of tumor immunosurveillance of pituitary adenomas. Diagn Pathol 2:20. doi: 10.1186\/1746-1596-2-20","journal-title":"Diagn Pathol"},{"key":"9709_CR103","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.beem.2010.03.001","volume":"24","author":"S Vandeva","year":"2010","unstructured":"Vandeva S, Jaffrain-Rea ML, Daly AF, Tichomirowa M, Zacharieva S, Beckers A (2010) The genetics of pituitary adenomas. Best Pract Res Clin Endocrinol Metab 24:461\u2013476. doi: 10.1016\/j.beem.2010.03.001","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"9709_CR104","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1210\/er.2006-0042","volume":"28","author":"G Vlotides","year":"2007","unstructured":"Vlotides G, Eigler T, Melmed S (2007) Pituitary tumor-transforming gene: physiology and implications for tumorigenesis. Endocr Rev 28:165\u2013186. doi: 10.1210\/er.2006-0042","journal-title":"Endocr Rev"},{"key":"9709_CR105","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nrendo.2012.54","volume":"8","author":"K Yacqub-Usman","year":"2012","unstructured":"Yacqub-Usman K, Richardson A, Duong CV, Clayton RN, Farrell WE (2012) The pituitary tumour epigenome: aberrations and prospects for targeted therapy. Nat Rev Endocrinol 8:486\u2013494. doi: 10.1038\/nrendo.2012.54","journal-title":"Nat Rev Endocrinol"},{"key":"9709_CR106","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11060-006-9316-9","volume":"83","author":"A Yoshino","year":"2007","unstructured":"Yoshino A, Katayama Y, Ogino A, Watanabe T, Yachi K, Ohta T, Komine C, Yokoyama T, Fukushima T (2007) Promoter hypermethylation profile of cell cycle regulator genes in pituitary adenomas. J Neurooncol 83:153\u2013162. doi: 10.1007\/s11060-006-9316-9","journal-title":"J Neurooncol"},{"key":"9709_CR107","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2012.06.008","volume":"22","author":"JS You","year":"2012","unstructured":"You JS, Jones PA (2012) Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell 22:9\u201320. doi: 10.1016\/j.ccr.2012.06.008","journal-title":"Cancer Cell"},{"key":"9709_CR108","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0079-6123(10)82009-6","volume":"182","author":"R Yu","year":"2010","unstructured":"Yu R, Melmed S (2010) Pathogenesis of pituitary tumors. Prog Brain Res 182:207\u2013227. doi: 10.1016\/S0079-6123(10)82009-6","journal-title":"Prog Brain Res"},{"key":"9709_CR109","doi-asserted-by":"crossref","first-page":"36502","DOI":"10.1074\/jbc.C000546200","volume":"275","author":"R Yu","year":"2000","unstructured":"Yu R, Heaney AP, Lu W, Chen J, Melmed S (2000) Pituitary tumor transforming gene causes aneuploidy and p53-dependent and p53-independent apoptosis. J Biol Chem 275:36502\u201336505. doi: 10.1074\/jbc.C000546200","journal-title":"J Biol Chem"},{"key":"9709_CR110","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1210\/en.2003-0305","volume":"144","author":"R Yu","year":"2003","unstructured":"Yu R, Lu W, Chen J, McCabe CJ, Melmed S (2003) Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells. Endocrinology 144:4991\u20134998. doi: 10.1210\/en.2003-0305","journal-title":"Endocrinology"},{"key":"9709_CR111","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1210\/jcem.84.2.5432","volume":"84","author":"X Zhang","year":"1999","unstructured":"Zhang X, Horwitz GA, Heaney AP, Nakashima M, Prezant TR, Bronstein MD, Melmed S (1999a) Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. J Clin Endocrinol Metab 84:761\u2013767. doi: 10.1210\/jcem.84.2.5432","journal-title":"J Clin Endocrinol Metab"},{"key":"9709_CR112","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1210\/mend.13.1.0225","volume":"13","author":"X Zhang","year":"1999","unstructured":"Zhang X, Horwitz GA, Prezant TR, Valentini A, Nakashima M, Bronstein MD, Melmed S (1999b) Structure, expression, and function of human pituitary tumor-transforming gene (PTTG). Mol Endocrinol 13:156\u2013166. doi: 10.1210\/mend.13.1.0225","journal-title":"Mol Endocrinol"},{"key":"9709_CR113","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/j.biocel.2012.08.005","volume":"44","author":"L Zhao","year":"2012","unstructured":"Zhao L, Sun Y, Hou Y, Peng Q, Wang L, Luo H, Tang X, Zeng Z, Liu M (2012) MiRNA expression analysis of cancer-associated fibroblasts and normal fibroblasts in breast cancer. Int J Biochem Cell Biol 44:2051\u20132059. doi: 10.1016\/j.biocel.2012.08.005","journal-title":"Int J Biochem Cell Biol"},{"key":"9709_CR114","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/35060032","volume":"3","author":"BP Zhou","year":"2001","unstructured":"Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC (2001) Cytoplasmic localization of p21Cip1\/WAF1 by Akt-induced phosphorylation in HER-2\/neu-overexpressing cells. Nat Cell Biol 3:245\u2013252. doi: 10.1038\/35060032","journal-title":"Nat Cell Biol"},{"key":"9709_CR115","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1210\/me.2009-0161","volume":"23","author":"C Zhou","year":"2009","unstructured":"Zhou C, Wawrowsky K, Bannykh S, Gutman S, Melmed S (2009) E2F1 induces pituitary tumor transforming gene (PTTG1) expression in human pituitary tumors. Mol Endocrinol 23:2000\u20132012. doi: 10.1210\/me.2009-0161","journal-title":"Mol Endocrinol"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-015-9709-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10528-015-9709-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-015-9709-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T22:17:08Z","timestamp":1567462628000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10528-015-9709-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,30]]},"references-count":112,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["9709"],"URL":"https:\/\/doi.org\/10.1007\/s10528-015-9709-6","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,30]]}}}