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Therefore, we set out to investigate whether distinct haplotypes of the two insertion\/deletion polymorphisms in the serotonin-transporter-linked polymorphic region (<jats:italic>5-HTTLPR<\/jats:italic>) and the angiotensin I-converting enzyme (<jats:italic>ACE<\/jats:italic>) gene located on chromosome 17 can be identified as risk factors for trajectories of depression. Clinical and genotyping data were derived from 507 depressed CAD patients participating in the randomized, controlled, multicenter Stepwise Psychotherapy Intervention for Reducing Risk in Coronary Artery Disease (SPIRR-CAD) trial, of whom the majority had an acute cardiac event before study inclusion. Depression scores on the Hospital Anxiety and Depression Scale (HADS) were assessed at baseline and at five follow-up time points up to 2\u00a0years after study entrance. At baseline, depression scores did not significantly differ between patients carrying the risk haplotype <jats:italic>ACE<\/jats:italic> D\/D, <jats:italic>5-HTTLPR<\/jats:italic> I\/I (<jats:italic>n<\/jats:italic>\u2009=\u200946) and the non-risk haplotypes (<jats:italic>n<\/jats:italic>\u2009=\u2009461, 10.9\u2009\u00b1\u20092.7 versus 10.4\u2009\u00b1\u20092.5, <jats:italic>p<\/jats:italic>\u2009=\u20090.254). HADS-depression scores declined from study inclusion during the first year irrespective of the genotype. At each follow-up time point, HADS-depression scores were significantly higher in <jats:italic>ACE<\/jats:italic> D\/D, <jats:italic>5-HTTLPR<\/jats:italic> I\/I carriers than in their counterparts. Two years after study inclusion, the mean HADS depression score remained 1.8 points higher in patients with the risk haplotype as compared to subjects not carrying this haplotype (9.9\u2009\u00b1\u20094.2 versus 8.1\u2009\u00b1\u20094.0, <jats:italic>p<\/jats:italic>\u2009=\u20090.009). In summary, the presence of the <jats:italic>ACE<\/jats:italic> D\/D, <jats:italic>5-HTTLPR<\/jats:italic> I\/I haplotype may be a vulnerability factor for comorbid depressive symptoms in CAD patients.<\/jats:p>","DOI":"10.1007\/s10528-020-09967-w","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T02:02:36Z","timestamp":1588644156000},"page":"631-648","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Length Polymorphisms in the Angiotensin I-Converting Enzyme Gene and the Serotonin-Transporter-Linked Polymorphic Region Constitute a Risk Haplotype for Depression in Patients with Coronary Artery Disease"],"prefix":"10.1007","volume":"58","author":[{"name":"for the SPIRR-CAD Investigators","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Meyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Rothe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Staab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Christian","family":"Deter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella V.","family":"Fangauf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Hamacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Hellmich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"J\u00fcnger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Heinz","family":"Ladwig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Michal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Petrowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joram","family":"Ronel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"S\u00f6llner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cora","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"de Zwaan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Redford B.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Albus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Herrmann-Lingen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"9967_CR1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2174\/1566524016666160126144143","volume":"16","author":"A Adibfar","year":"2016","unstructured":"Adibfar A, Saleem M, Lanctot KL, Herrmann N (2016) Potential biomarkers for depression associated with coronary artery disease: a critical review. 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