{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:37:07Z","timestamp":1789425427471,"version":"build-2803163510"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Shanghai Sailing Program","award":["17YF1402100"],"award-info":[{"award-number":["17YF1402100"]}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Science and Technology Committee","doi-asserted-by":"crossref","award":["14DZ1940902"],"award-info":[{"award-number":["14DZ1940902"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Zhongshan Hospital Key Staffs Program","award":["2015ZSYXGG05"],"award-info":[{"award-number":["2015ZSYXGG05"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801844"],"award-info":[{"award-number":["81801844"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s10528-021-10085-4","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T19:02:41Z","timestamp":1625079761000},"page":"286-302","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Two MicroRNAs, miR-34a and miR-125a, Are Implicated in Bicuspid Aortopathy by Modulating Metalloproteinase 2"],"prefix":"10.1007","volume":"60","author":[{"given":"Yuntao","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyue","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoning","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqiang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Rafi","family":"Hamidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mofang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6008-8567","authenticated-orcid":false,"given":"Lai","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"10085_CR1","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1093\/icvts\/ivt196","volume":"17","author":"N Abdulkareem","year":"2013","unstructured":"Abdulkareem N, Smelt J, Jahangiri M (2013) Bicuspid aortic valve aortopathy: genetics, pathophysiology and medical therapy. Interact Cardiovasc Thorac Surg 17:554\u2013559","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10085_CR2","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1136\/heartjnl-2014-306601","volume":"101","author":"L Adamo","year":"2015","unstructured":"Adamo L, Braverman AC (2015) Surgical threshold for bicuspid aortic valve aneurysm: a case for individual decision-making. Heart 101:1361\u20131367","journal-title":"Heart"},{"key":"10085_CR3","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1161\/STROKEAHA.115.010567","volume":"46","author":"HA Bazan","year":"2015","unstructured":"Bazan HA, Hatfield SA, O\u2019Malley CB, Brooks AJ, Lightell D Jr, Woods TC (2015) Acute loss of miR-221 and miR-222 in the atherosclerotic plaque shoulder accompanies plaque rupture. Stroke 46:3285\u20133287","journal-title":"Stroke"},{"key":"10085_CR4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/pr.2014.67","volume":"76","author":"EM Bonachea","year":"2014","unstructured":"Bonachea EM, Chang SW, Zender G, LaHaye S, Fitzgerald-Butt S, McBride KL, Garg V (2014) Rare GATA5 sequence variants identified in individuals with bicuspid aortic valve. Pediatr Res 76:211\u2013216","journal-title":"Pediatr Res"},{"key":"10085_CR5","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1159\/000087451","volume":"42","author":"M Browatzki","year":"2005","unstructured":"Browatzki M, Larsen D, Pfeiffer CA, Gehrke SG, Schmidt J, Kranzhofer A, Katus HA, Kranzhofer R (2005) Angiotensin II stimulates matrix metalloproteinase secretion in human vascular smooth muscle cells via nuclear factor-kappaB and activator protein 1 in a redox-sensitive manner. J Vasc Res 42:415\u2013423","journal-title":"J Vasc Res"},{"key":"10085_CR6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1672-0229(08)60044-3","volume":"7","author":"Y Cai","year":"2009","unstructured":"Cai Y, Yu X, Hu S, Yu J (2009) A brief review on the mechanisms of miRNA regulation. Genom Proteom Bioinform 7:147\u2013154","journal-title":"Genom Proteom Bioinform"},{"key":"10085_CR7","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2798","author":"K Cao","year":"2016","unstructured":"Cao K, Sucosky P (2016) Computational comparison of regional stress and deformation characteristics in tricuspid and bicuspid aortic valve leaflets. Int J Numer Method Biomed Eng. https:\/\/doi.org\/10.1002\/cnm.2798","journal-title":"Int J Numer Method Biomed Eng"},{"key":"10085_CR8","doi-asserted-by":"crossref","first-page":"e96577","DOI":"10.1371\/journal.pone.0096577","volume":"9","author":"K Carrion","year":"2014","unstructured":"Carrion K, Dyo J, Patel V, Sasik R, Mohamed SA, Hardiman G, Nigam V (2014) The long non-coding HOTAIR is modulated by cyclic stretch and WNT\/beta-CATENIN in human aortic valve cells and is a novel repressor of calcification genes. PloS one 9:e96577","journal-title":"PloS one"},{"key":"10085_CR9","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1182\/blood-2007-07-104133","volume":"111","author":"Y Chen","year":"2008","unstructured":"Chen Y, Gorski DH (2008) Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5. Blood 111:1217\u20131226","journal-title":"Blood"},{"key":"10085_CR10","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jacc.2004.03.050","volume":"44","author":"L Cripe","year":"2004","unstructured":"Cripe L, Andelfinger G, Martin LJ, Shooner K, Benson DW (2004) Bicuspid aortic valve is heritable. J Am Coll Cardiol 44:138\u2013143","journal-title":"J Am Coll Cardiol"},{"key":"10085_CR11","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1074\/mcp.M110.001693","volume":"9","author":"A Didangelos","year":"2010","unstructured":"Didangelos A, Yin X, Mandal K, Baumert M, Jahangiri M, Mayr M (2010) Proteomics characterization of extracellular space components in the human aorta. Molecular & Cellular Proteomics\u202f: MCP 9:2048\u20132062","journal-title":"Molecular & Cellular Proteomics : MCP"},{"key":"10085_CR12","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1101\/gad.1184404","volume":"18","author":"JG Doench","year":"2004","unstructured":"Doench JG, Sharp PA (2004) Specificity of microRNA target selection in translational repression. Genes Dev 18:504\u2013511","journal-title":"Genes Dev"},{"key":"10085_CR13","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1161\/01.HYP.37.4.1047","volume":"37","author":"VJ Dzau","year":"2001","unstructured":"Dzau VJ (2001) Theodore cooper lecture: tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis. Hypertension 37:1047\u20131052","journal-title":"Hypertension"},{"key":"10085_CR14","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0022-5223(03)00398-2","volume":"126","author":"PW Fedak","year":"2003","unstructured":"Fedak PW, de Sa MP, Verma S, Nili N, Kazemian P, Butany J, Strauss BH, Weisel RD, David TE (2003) Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation. J Thorac Cardiovasc Surg 126:797\u2013806","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10085_CR15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1471-2350-14-44","volume":"14","author":"I Foffa","year":"2013","unstructured":"Foffa I, Ait Ali L, Panesi P, Mariani M, Festa P, Botto N, Vecoli C, Andreassi MG (2013) Sequencing of NOTCH1, GATA5, TGFBR1 and TGFBR2 genes in familial cases of bicuspid aortic valve. BMC Med Genet 14:44","journal-title":"BMC Med Genet"},{"key":"10085_CR16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1042\/CS20120324","volume":"124","author":"A Forte","year":"2013","unstructured":"Forte A, Della Corte A, Grossi M, Bancone C, Provenzano R, Finicelli M, De Feo M, De Santo LS, Nappi G, Cotrufo M et al (2013) Early cell changes and TGFbeta pathway alterations in the aortopathy associated with bicuspid aortic valve stenosis. Clin Sci 124:97\u2013108","journal-title":"Clin Sci"},{"key":"10085_CR17","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1161\/CIRCRESAHA.117.310833","volume":"120","author":"A Forte","year":"2017","unstructured":"Forte A, Bancone C, Cobellis G, Buonocore M, Santarpino G, Fischlein TJM, Cipollaro M, De Feo M, Della Corte A (2017) A possible early biomarker for bicuspid aortopathy: circulating transforming growth factor beta-1 to soluble endoglin ratio. Circ Res 120:1800\u20131811","journal-title":"Circ Res"},{"key":"10085_CR18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1161\/res.90.3.251","volume":"90","author":"ZS Galis","year":"2002","unstructured":"Galis ZS, Khatri JJ (2002) Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res 90:251\u2013262","journal-title":"Circ Res"},{"key":"10085_CR19","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nature03940","volume":"437","author":"V Garg","year":"2005","unstructured":"Garg V, Muth AN, Ransom JF, Schluterman MK, Barnes R, King IN, Grossfeld PD, Srivastava D (2005) Mutations in NOTCH1 cause aortic valve disease. Nature 437:270\u2013274","journal-title":"Nature"},{"key":"10085_CR20","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrm3838","volume":"15","author":"M Ha","year":"2014","unstructured":"Ha M, Kim VN (2014) Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol 15:509\u2013524","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10085_CR21","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","volume":"39","author":"JI Hoffman","year":"2002","unstructured":"Hoffman JI, Kaplan S (2002) The incidence of congenital heart disease. J Am Coll Cardiol 39:1890\u20131900","journal-title":"J Am Coll Cardiol"},{"key":"10085_CR22","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1038\/emboj.2012.45","volume":"31","author":"S Jiang","year":"2012","unstructured":"Jiang S, Zhang LF, Zhang HW, Hu S, Lu MH, Liang S, Li B, Li Y, Li D, Wang ED, Liu MF (2012) A novel miR-155\/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells. EMBO J 31:1985\u20131998","journal-title":"EMBO J"},{"key":"10085_CR23","doi-asserted-by":"crossref","first-page":"31268","DOI":"10.1038\/srep31268","volume":"6","author":"H Kugo","year":"2016","unstructured":"Kugo H, Zaima N, Tanaka H, Mouri Y, Yanagimoto K, Hayamizu K, Hashimoto K, Sasaki T, Sano M, Yata T et al (2016) Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm. Sci Rep 6:31268","journal-title":"Sci Rep"},{"key":"10085_CR24","doi-asserted-by":"crossref","first-page":"17156","DOI":"10.1074\/jbc.M111.231571","volume":"286","author":"WE Kutz","year":"2011","unstructured":"Kutz WE, Wang LW, Bader HL, Majors AK, Iwata K, Traboulsi EI, Sakai LY, Keene DR, Apte SS (2011) ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts. J Biol Chem 286:17156\u201317167","journal-title":"J Biol Chem"},{"key":"10085_CR25","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1172\/JCI44555","volume":"121","author":"B Laforest","year":"2011","unstructured":"Laforest B, Andelfinger G, Nemer M (2011) Loss of Gata5 in mice leads to bicuspid aortic valve. J Clin Investig 121:2876\u20132887","journal-title":"J Clin Investig"},{"key":"10085_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13040-014-0034-0","volume":"8","author":"WB Langdon","year":"2015","unstructured":"Langdon WB (2015) Performance of genetic programming optimised Bowtie2 on genome comparison and analytic testing (GCAT) benchmarks. BioData Min 8:1","journal-title":"BioData Min"},{"key":"10085_CR27","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jss.2004.06.007","volume":"123","author":"SA LeMaire","year":"2005","unstructured":"LeMaire SA, Wang X, Wilks JA, Carter SA, Wen S, Won T, Leonardelli D, Anand G, Conklin LD, Wang XL et al (2005) Matrix metalloproteinases in ascending aortic aneurysms: bicuspid versus trileaflet aortic valves. J Surg Res 123:40\u201348","journal-title":"J Surg Res"},{"key":"10085_CR28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/ng0797-243","volume":"16","author":"L Li","year":"1997","unstructured":"Li L, Krantz ID, Deng Y, Genin A, Banta AB, Collins CC, Qi M, Trask BJ, Kuo WL, Cochran J et al (1997) Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet 16:243\u2013251","journal-title":"Nat Genet"},{"key":"10085_CR29","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1093\/hmg\/8.13.2443","volume":"8","author":"KM Loomes","year":"1999","unstructured":"Loomes KM, Underkoffler LA, Morabito J, Gottlieb S, Piccoli DA, Spinner NB, Baldwin HS, Oakey RJ (1999) The expression of Jagged1 in the developing mammalian heart correlates with cardiovascular disease in Alagille syndrome. Hum Mol Genet 8:2443\u20132449","journal-title":"Hum Mol Genet"},{"key":"10085_CR30","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1161\/CIRCULATIONAHA.107.740878","volume":"117","author":"HI Michelena","year":"2008","unstructured":"Michelena HI, Desjardins VA, Avierinos JF, Russo A, Nkomo VT, Sundt TM, Pellikka PA, Tajik AJ, Enriquez-Sarano M (2008) Natural history of asymptomatic patients with normally functioning or minimally dysfunctional bicuspid aortic valve in the community. Circulation 117:2776\u20132784","journal-title":"Circulation"},{"key":"10085_CR31","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.jtcvs.2005.08.017","volume":"130","author":"SA Mohamed","year":"2005","unstructured":"Mohamed SA, Hanke T, Schlueter C, Bullerdiek J, Sievers HH (2005) Ubiquitin fusion degradation 1-like gene dysregulation in bicuspid aortic valve. J Thorac Cardiovasc Surg 130:1531\u20131536","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"8","key":"10085_CR32","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1080\/1354750X.2020.1841297","volume":"25","author":"S Naito","year":"2020","unstructured":"Naito S, Petersen J, Sequeira-Gross T, Neumann N, Duque EJ, Zeller T, Reichenspurner H, Girdauskas E (2020) Bicuspid aortopathy\u2014molecular involvement of microRNAs and MMP-TIMP. Biomarkers 25(8):711\u2013718","journal-title":"Biomarkers"},{"key":"10085_CR33","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.cardiores.2005.08.002","volume":"69","author":"AC Newby","year":"2006","unstructured":"Newby AC (2006) Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates. Cardiovasc Res 69:614\u2013624","journal-title":"Cardiovasc Res"},{"key":"10085_CR34","first-page":"459","volume":"19","author":"V Nigam","year":"2010","unstructured":"Nigam V, Sievers HH, Jensen BC, Sier HA, Simpson PC, Srivastava D, Mohamed SA (2010) Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves. J Heart Valve Dis 19:459\u2013465","journal-title":"J Heart Valve Dis"},{"issue":"22","key":"10085_CR35","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/j.jacc.2014.02.536","volume":"63","author":"RA Nishimura","year":"2014","unstructured":"Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JR, Guyton RA, O\u2019Gara PT, Ruiz CE, Skubas NJ, Sorajja P et al (2014) 2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines. J AM COLL CARDIOL 63(22):e57\u2013e185","journal-title":"J AM COLL CARDIOL"},{"key":"10085_CR36","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1096\/fj.14-257808","volume":"29","author":"V Patel","year":"2015","unstructured":"Patel V, Carrion K, Hollands A, Hinton A, Gallegos T, Dyo J, Sasik R, Leire E, Hardiman G, Mohamed SA et al (2015) The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-kappaB signaling, and inflammatory gene expression in human aortic valve cells. FASEB J 29:1859\u20131868","journal-title":"FASEB J"},{"key":"10085_CR37","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1186\/s12885-015-1359-x","volume":"15","author":"P Qiao","year":"2015","unstructured":"Qiao P, Li G, Bi W, Yang L, Yao L, Wu D (2015) microRNA-34a inhibits epithelial mesenchymal transition in human cholangiocarcinoma by targeting Smad4 through transforming growth factor-beta\/Smad pathway. BMC Cancer 15:469","journal-title":"BMC Cancer"},{"key":"10085_CR38","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi1112s47","author":"AR Quinlan","year":"2014","unstructured":"Quinlan AR (2014) BEDTools: the Swiss-army tool for genome feature analysis. Curr Protoc Bioinform. https:\/\/doi.org\/10.1002\/0471250953.bi1112s47","journal-title":"Curr Protoc Bioinform"},{"key":"10085_CR39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.abb.2016.02.003","volume":"594","author":"Z Rasheed","year":"2016","unstructured":"Rasheed Z, Al-Shobaili HA, Rasheed N, Mahmood A, Khan MI (2016) MicroRNA-26a-5p regulates the expression of inducible nitric oxide synthase via activation of NF-kappaB pathway in human osteoarthritis chondrocytes. Arch Biochem Biophys 594:61\u201367","journal-title":"Arch Biochem Biophys"},{"key":"10085_CR40","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1136\/heart.89.9.1074","volume":"89","author":"JW Roos-Hesselink","year":"2003","unstructured":"Roos-Hesselink JW, Scholzel BE, Heijdra RJ, Spitaels SE, Meijboom FJ, Boersma E, Bogers AJ, Simoons ML (2003) Aortic valve and aortic arch pathology after coarctation repair. Heart 89:1074\u20131077","journal-title":"Heart"},{"key":"10085_CR41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/cvr\/cvp015","volume":"82","author":"S Roy","year":"2009","unstructured":"Roy S, Khanna S, Hussain SR, Biswas S, Azad A, Rink C, Gnyawali S, Shilo S, Nuovo GJ, Sen CK (2009) MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. Cardiovasc Res 82:21\u201329","journal-title":"Cardiovasc Res"},{"key":"10085_CR42","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.3892\/ijmm.2014.1700","volume":"33","author":"LM Shi","year":"2014","unstructured":"Shi LM, Tao JW, Qiu XB, Wang J, Yuan F, Xu L, Liu H, Li RG, Xu YJ, Wang Q et al (2014) GATA5 loss-of-function mutations associated with congenital bicuspid aortic valve. Int J Mol Med 33:1219\u20131226","journal-title":"Int J Mol Med"},{"key":"10085_CR43","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/nar\/gkt1156","volume":"42","author":"MW Szczesniak","year":"2014","unstructured":"Szczesniak MW, Makalowska I (2014) miRNEST 2.0: a database of plant and animal microRNAs. Nucl Acids Res 42:74\u201377","journal-title":"Nucl Acids Res"},{"key":"10085_CR44","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1177\/2150135113501901","volume":"4","author":"K Szeto","year":"2013","unstructured":"Szeto K, Pastuszko P, del Alamo JC, Lasheras J, Nigam V (2013) Bicuspid aortic valves experience increased strain as compared to tricuspid aortic valves. World J Pediatr Congenit Heart Surg 4:362\u2013366","journal-title":"World J Pediatr Congenit Heart Surg"},{"key":"10085_CR45","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ng1636","volume":"37","author":"MA Tischfield","year":"2005","unstructured":"Tischfield MA, Bosley TM, Salih MA, Alorainy IA, Sener EC, Nester MJ, Oystreck DT, Chan WM, Andrews C, Erickson RP, Engle EC (2005) Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development. Nat Genet 37:1035\u20131037","journal-title":"Nat Genet"},{"key":"10085_CR46","doi-asserted-by":"crossref","first-page":"13027","DOI":"10.1073\/pnas.0805038105","volume":"105","author":"E van Rooij","year":"2008","unstructured":"van Rooij E, Sutherland LB, Thatcher JE, DiMaio JM, Naseem RH, Marshall WS, Hill JA, Olson EN (2008) Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci USA 105:13027\u201313032","journal-title":"Proc Natl Acad Sci USA"},{"key":"10085_CR47","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1510\/icvts.2007.163311","volume":"7","author":"E Wilton","year":"2008","unstructured":"Wilton E, Bland M, Thompson M, Jahangiri M (2008) Matrix metalloproteinase expression in the ascending aorta and aortic valve. Interact Cardiovasc Thorac Surg 7:37\u201340","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10085_CR48","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1016\/j.jacc.2016.04.027","volume":"67","author":"J Wu","year":"2016","unstructured":"Wu J, Song HF, Li SH, Guo J, Tsang K, Tumiati L, Butany J, Yau TM, Ouzounian M, Fu S et al (2016) Progressive aortic dilation Is regulated by miR-17-associated miRNAs. J Am Coll Cardiol 67:2965\u20132977","journal-title":"J Am Coll Cardiol"},{"key":"10085_CR49","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.atherosclerosis.2015.06.031","volume":"241","author":"Y Xue","year":"2015","unstructured":"Xue Y, Wei Z, Ding H, Wang Q, Zhou Z, Zheng S, Zhang Y, Hou D, Liu Y, Zen K et al (2015) MicroRNA-19b\/221\/222 induces endothelial cell dysfunction via suppression of PGC-1alpha in the progression of atherosclerosis. Atherosclerosis 241:671\u2013681","journal-title":"Atherosclerosis"},{"key":"10085_CR50","doi-asserted-by":"crossref","first-page":"H721","DOI":"10.1152\/ajpheart.00829.2011","volume":"303","author":"CH Yap","year":"2012","unstructured":"Yap CH, Saikrishnan N, Tamilselvan G, Vasilyev N, Yoganathan AP (2012) The congenital bicuspid aortic valve can experience high-frequency unsteady shear stresses on its leaflet surface. Am J Physiol Heart Circ Physiol 303:H721-731","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10085_CR51","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.15252\/embj.201591803","volume":"34","author":"LF Zhang","year":"2015","unstructured":"Zhang LF, Lou JT, Lu MH, Gao C, Zhao S, Li B, Liang S, Li Y, Li D, Liu MF (2015) Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma. EMBO J 34:2671\u20132685","journal-title":"EMBO J"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-021-10085-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-021-10085-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-021-10085-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T22:09:50Z","timestamp":1643148590000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10528-021-10085-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10085"],"URL":"https:\/\/doi.org\/10.1007\/s10528-021-10085-4","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,30]]},"assertion":[{"value":"5 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the Ethics Committee of Zhongshan Hospital (Reference Number: 20121022001) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All author approve participation in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All author approve publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}