{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:28:47Z","timestamp":1780363727770,"version":"3.54.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s10528-023-10612-5","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T19:02:48Z","timestamp":1704394968000},"page":"3642-3657","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["MicroRNA-195-5p Attenuates Pregnancy-Induced Hypertension by Inhibiting Oxidative Stress via OTX1\/MAPK Signaling Pathway"],"prefix":"10.1007","volume":"62","author":[{"given":"Lili","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfeng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"key":"10612_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jbior.2014.09.013","volume":"57","author":"M Acunzo","year":"2015","unstructured":"Acunzo M et al (2015) MicroRNA and cancer\u2014a brief overview. Adv Biol Regul 57:1\u20139","journal-title":"Adv Biol Regul"},{"key":"10612_CR2","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.preghy.2020.01.002","volume":"19","author":"Z Awamleh","year":"2020","unstructured":"Awamleh Z, Han VKM (2020) Identification of miR-210-5p in human placentae from pregnancies complicated by preeclampsia and intrauterine growth restriction, and its potential role in the pregnancy complications. Pregnancy Hypertens 19:159\u2013168","journal-title":"Pregnancy Hypertens"},{"key":"10612_CR3","doi-asserted-by":"publisher","first-page":"166449","DOI":"10.1016\/j.scitotenv.2023.166449","volume":"903","author":"J Bai","year":"2023","unstructured":"Bai J et al (2023) Chlorpyrifos induces placental oxidative stress and barrier dysfunction by inducing mitochondrial apoptosis through the ERK\/MAPK signaling pathway: in vitro and in vivo studies. Sci Total Environ 903:166449","journal-title":"Sci Total Environ"},{"issue":"1","key":"10612_CR4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","volume":"173","author":"DP Bartel","year":"2018","unstructured":"Bartel DP (2018) Metazoan MicroRNAs. Cell 173(1):20\u201351","journal-title":"Cell"},{"key":"10612_CR5","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1186\/s12935-020-01580-6","volume":"20","author":"FY Chen","year":"2020","unstructured":"Chen FY et al (2020) Long non-coding RNA MIR100HG promotes the migration, invasion and proliferation of triple-negative breast cancer cells by targeting the miR-5590-3p\/OTX1 axis. Cancer Cell Int 20:508","journal-title":"Cancer Cell Int"},{"issue":"2","key":"10612_CR6","doi-asserted-by":"publisher","first-page":"165354","DOI":"10.1016\/j.bbadis.2018.12.005","volume":"1866","author":"DI Chiarello","year":"2020","unstructured":"Chiarello DI et al (2020) Oxidative stress: Normal pregnancy versus preeclampsia. Biochim Biophys Acta Mol Basis Dis 1866(2):165354","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"4","key":"10612_CR8","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.3892\/etm.2017.4882","volume":"14","author":"Z Gao","year":"2017","unstructured":"Gao Z et al (2017) Molecular mechanism of miR-181b in heart disease due to pregnancy-induced hypertension syndrome. Exp Ther Med 14(4):2953\u20132959","journal-title":"Exp Ther Med"},{"issue":"13","key":"10612_CR9","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.3390\/ijms23137167","volume":"23","author":"PTB Ho","year":"2022","unstructured":"Ho PTB, Clark IM, Le LTT (2022) MicroRNA-based diagnosis and therapy. Int J Mol Sci 23(13):1215","journal-title":"Int J Mol Sci"},{"key":"10612_CR10","doi-asserted-by":"publisher","first-page":"e2502","DOI":"10.6061\/clinics\/2021\/e2502","volume":"76","author":"Y Hu","year":"2021","unstructured":"Hu Y et al (2021) Serum miR-195-5p exhibits clinical significance in the diagnosis of essential hypertension with type 2 diabetes mellitus by targeting DRD1. Clinics (sao Paulo) 76:e2502","journal-title":"Clinics (sao Paulo)"},{"issue":"6","key":"10612_CR11","first-page":"659","volume":"38","author":"S Hu","year":"2023","unstructured":"Hu S et al (2023) MiR-195-5p suppresses gastric adenocarcinoma cell progression via targeting OTX1. Histol Histopathol 38(6):659\u2013668","journal-title":"Histol Histopathol"},{"issue":"6","key":"10612_CR12","doi-asserted-by":"publisher","first-page":"953","DOI":"10.3390\/biom10060953","volume":"10","author":"MK Jena","year":"2020","unstructured":"Jena MK et al (2020) Pathogenesis of preeclampsia and therapeutic approaches targeting the placenta. Biomolecules 10(6):953","journal-title":"Biomolecules"},{"issue":"2","key":"10612_CR13","doi-asserted-by":"publisher","first-page":"211","DOI":"10.14310\/horm.2002.1582","volume":"14","author":"E Kintiraki","year":"2015","unstructured":"Kintiraki E et al (2015) Pregnancy-induced hypertension. Hormones (athens) 14(2):211\u2013223","journal-title":"Hormones (athens)"},{"issue":"3","key":"10612_CR14","doi-asserted-by":"publisher","first-page":"138","DOI":"10.5551\/jat.12.138","volume":"12","author":"M Kobayashi","year":"2005","unstructured":"Kobayashi M et al (2005) A simple method of isolating mouse aortic endothelial cells. J Atheroscler Thromb 12(3):138\u2013142","journal-title":"J Atheroscler Thromb"},{"issue":"7","key":"10612_CR15","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1369\/jhc.2010.955757","volume":"58","author":"KB Larsen","year":"2010","unstructured":"Larsen KB et al (2010) Expression of the homeobox genes OTX2 and OTX1 in the early developing human brain. J Histochem Cytochem 58(7):669\u2013678","journal-title":"J Histochem Cytochem"},{"issue":"8","key":"10612_CR16","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.3346\/jkms.2016.31.8.1215","volume":"31","author":"H Li","year":"2016","unstructured":"Li H et al (2016) OTX1 contributes to hepatocellular carcinoma progression by regulation of ERK\/MAPK pathway. J Korean Med Sci 31(8):1215\u20131223","journal-title":"J Korean Med Sci"},{"issue":"1","key":"10612_CR17","doi-asserted-by":"publisher","first-page":"418","DOI":"10.3892\/etm.2020.8719","volume":"20","author":"J Li","year":"2020","unstructured":"Li J, Wu Y, Liu H (2020) Expression and role of miR-338-3p in peripheral blood and placenta of patients with pregnancy-induced hypertension. Exp Ther Med 20(1):418\u2013426","journal-title":"Exp Ther Med"},{"issue":"2","key":"10612_CR18","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1080\/10641955.2022.2056195","volume":"41","author":"JY Li","year":"2022","unstructured":"Li JY et al (2022a) MiR-140-5p exerts a protective function in pregnancy-induced hypertension via mediating TGF-\u03b2\/Smad signaling pathway. Hypertens Pregnancy 41(2):116\u2013125","journal-title":"Hypertens Pregnancy"},{"issue":"2","key":"10612_CR19","doi-asserted-by":"publisher","first-page":"100631","DOI":"10.1016\/j.repbio.2022.100631","volume":"22","author":"K Li","year":"2022","unstructured":"Li K et al (2022b) CircFN1 upregulation initiated oxidative stress-induced apoptosis and inhibition of proliferation and migration in trophoblasts via circFN1-miR-19a\/b-3p-ATF2 ceRNA network. Reprod Biol 22(2):100631","journal-title":"Reprod Biol"},{"key":"10612_CR20","doi-asserted-by":"publisher","first-page":"153773","DOI":"10.1016\/j.phymed.2021.153773","volume":"93","author":"M Liu","year":"2021","unstructured":"Liu M et al (2021) Atractylenolide inhibits apoptosis and oxidative stress of HTR-8\/SVneo cells by activating MAPK\/ERK signalling in preeclampsia. Phytomedicine 93:153773","journal-title":"Phytomedicine"},{"key":"10612_CR21","doi-asserted-by":"publisher","first-page":"104231","DOI":"10.1016\/j.mvr.2021.104231","volume":"139","author":"Z Liu","year":"2022","unstructured":"Liu Z, Guo N, Zhang XJ (2022) Long noncoding TUG1 promotes angiogenesis of HUVECs in PE via regulating the miR-29a-3p\/VEGFA and Ang2\/Tie2 pathways. Microvasc Res 139:104231","journal-title":"Microvasc Res"},{"issue":"4","key":"10612_CR22","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25(4):402\u2013408","journal-title":"Methods"},{"issue":"3\u20134","key":"10612_CR23","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1159\/000452566","volume":"40","author":"JY Luo","year":"2016","unstructured":"Luo JY et al (2016) Inhibition of the JAK2\/STAT3\/SOSC1 signaling pathway improves secretion function of vascular endothelial cells in a rat model of pregnancy-induced hypertension. Cell Physiol Biochem 40(3\u20134):527\u2013537","journal-title":"Cell Physiol Biochem"},{"issue":"11","key":"10612_CR24","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1016\/j.mayocp.2018.04.033","volume":"93","author":"LA Magee","year":"2018","unstructured":"Magee LA, von Dadelszen P (2018) State-of-the-art diagnosis and treatment of hypertension in pregnancy. Mayo Clin Proc 93(11):1664\u20131677","journal-title":"Mayo Clin Proc"},{"issue":"3","key":"10612_CR25","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1161\/HYPERTENSIONAHA.114.03315","volume":"64","author":"MQ Mazzuca","year":"2014","unstructured":"Mazzuca MQ et al (2014) Downregulation of microvascular endothelial type B endothelin receptor is a central vascular mechanism in hypertensive pregnancy. Hypertension 64(3):632\u2013643","journal-title":"Hypertension"},{"key":"10612_CR26","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav1741","author":"SE McGeary","year":"2019","unstructured":"McGeary SE et al (2019) The biochemical basis of microRNA targeting efficacy. Science. https:\/\/doi.org\/10.1126\/science.aav1741","journal-title":"Science"},{"issue":"4","key":"10612_CR27","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1002\/jcp.24469","volume":"229","author":"M Ou","year":"2014","unstructured":"Ou M et al (2014) Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats. J Cell Physiol 229(4):489\u2013501","journal-title":"J Cell Physiol"},{"issue":"5","key":"10612_CR28","doi-asserted-by":"publisher","first-page":"6070","DOI":"10.1096\/fj.201902280R","volume":"34","author":"M Ou","year":"2020","unstructured":"Ou M et al (2020) Long noncoding RNA MALAT1 contributes to pregnancy-induced hypertension development by enhancing oxidative stress and inflammation through the regulation of the miR-150-5p\/ET-1 axis. Faseb j 34(5):6070\u20136085","journal-title":"Faseb j"},{"key":"10612_CR29","doi-asserted-by":"publisher","first-page":"5581570","DOI":"10.1155\/2021\/5581570","volume":"2021","author":"WN Phoswa","year":"2021","unstructured":"Phoswa WN, Khaliq OP (2021) The role of oxidative stress in hypertensive disorders of pregnancy (preeclampsia, gestational hypertension) and metabolic disorder of pregnancy (gestational diabetes mellitus). Oxid Med Cell Longev 2021:5581570","journal-title":"Oxid Med Cell Longev"},{"issue":"6","key":"10612_CR30","doi-asserted-by":"publisher","first-page":"e0178702","DOI":"10.1371\/journal.pone.0178702","volume":"12","author":"ZZ Rao","year":"2017","unstructured":"Rao ZZ et al (2017) miR-148a-mediated estrogen-induced cholestasis in intrahepatic cholestasis of pregnancy: role of PXR\/MRP3. PLoS ONE 12(6):e0178702","journal-title":"PLoS ONE"},{"key":"10612_CR31","doi-asserted-by":"crossref","unstructured":"Report of the national high blood pressure education program working group on high blood pressure in pregnancy. Am J Obstet Gynecol, 2000. 183(1): S1\u2013s22.","DOI":"10.1067\/mob.2000.107928"},{"issue":"6","key":"10612_CR32","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1111\/jcmm.12767","volume":"20","author":"VC Sandrim","year":"2016","unstructured":"Sandrim VC et al (2016) Plasma from pre-eclamptic patients induces the expression of the anti-angiogenic miR-195-5p in endothelial cells. J Cell Mol Med 20(6):1198\u20131200","journal-title":"J Cell Mol Med"},{"issue":"8","key":"10612_CR33","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1080\/14656566.2019.1594773","volume":"20","author":"J Tamargo","year":"2019","unstructured":"Tamargo J, Caballero R, Delp\u00f3n E (2019) Pharmacotherapy for hypertension in pregnant patients: special considerations. Expert Opin Pharmacother 20(8):963\u2013982","journal-title":"Expert Opin Pharmacother"},{"key":"10612_CR34","doi-asserted-by":"publisher","first-page":"3795060","DOI":"10.1155\/2022\/3795060","volume":"2022","author":"F Tang","year":"2022","unstructured":"Tang F et al (2022) lncRNA H19 promotes Ox-LDL-induced dysfunction of human aortic endothelial cells through the miR-152\/VEGFA axis. J Healthc Eng 2022:3795060","journal-title":"J Healthc Eng"},{"key":"10612_CR35","doi-asserted-by":"publisher","first-page":"6398520","DOI":"10.1155\/2020\/6398520","volume":"2020","author":"K Tobo\u0142a-Wr\u00f3bel","year":"2020","unstructured":"Tobo\u0142a-Wr\u00f3bel K et al (2020) Association of oxidative stress on pregnancy. Oxid Med Cell Longev 2020:6398520","journal-title":"Oxid Med Cell Longev"},{"issue":"11","key":"10612_CR7","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1007\/s00228-022-03382-3","volume":"78","author":"D Van de Vusse","year":"2022","unstructured":"Van de Vusse D et al (2022) Pharmacokinetics of the most commonly used antihypertensive drugs throughout pregnancy methyldopa, labetalol, and nifedipine: a systematic review. Eur J Clin Pharmacol 78(11):1763\u20131776. https:\/\/doi.org\/10.1007\/s00228-022-03382-3","journal-title":"Eur J Clin Pharmacol"},{"issue":"5","key":"10612_CR36","doi-asserted-by":"publisher","first-page":"7141","DOI":"10.1002\/jcp.27468","volume":"234","author":"P Wang","year":"2019","unstructured":"Wang P et al (2019) Dysregulation of microRNA-657 influences inflammatory response via targeting interleukin-37 in gestational diabetes mellitus. J Cell Physiol 234(5):7141\u20137148","journal-title":"J Cell Physiol"},{"issue":"6","key":"10612_CR37","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1161\/HYPERTENSIONAHA.113.02647","volume":"63","author":"P Xu","year":"2014","unstructured":"Xu P et al (2014) Variations of microRNAs in human placentas and plasma from preeclamptic pregnancy. Hypertension 63(6):1276\u20131284","journal-title":"Hypertension"},{"issue":"11","key":"10612_CR38","doi-asserted-by":"publisher","first-page":"10235","DOI":"10.18632\/aging.103160","volume":"12","author":"Y Xu","year":"2020","unstructured":"Xu Y et al (2020) miR-195-5p alleviates acute kidney injury through repression of inflammation and oxidative stress by targeting vascular endothelial growth factor A. Aging 12(11):10235\u201310245","journal-title":"Aging"},{"issue":"5","key":"10612_CR39","doi-asserted-by":"publisher","first-page":"4530","DOI":"10.1002\/jcp.29330","volume":"235","author":"Y Yuan","year":"2020","unstructured":"Yuan Y et al (2020) MicroRNA-16 is involved in the pathogenesis of pre-eclampsia via regulation of Notch2. J Cell Physiol 235(5):4530\u20134544","journal-title":"J Cell Physiol"},{"issue":"2","key":"10612_CR40","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1002\/jcb.26376","volume":"119","author":"Z Zeng","year":"2018","unstructured":"Zeng Z et al (2018) Anti-apoptosis endothelial cell-secreted microRNA-195-5p promotes pulmonary arterial smooth muscle cell proliferation and migration in pulmonary arterial hypertension. J Cell Biochem 119(2):2144\u20132155","journal-title":"J Cell Biochem"},{"key":"10612_CR41","doi-asserted-by":"publisher","first-page":"101402","DOI":"10.1016\/j.redox.2019.101402","volume":"29","author":"H Zhang","year":"2020","unstructured":"Zhang H et al (2020) miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia. Redox Biol 29:101402","journal-title":"Redox Biol"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-023-10612-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-023-10612-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-023-10612-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T20:27:31Z","timestamp":1727382451000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10528-023-10612-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,4]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10612"],"URL":"https:\/\/doi.org\/10.1007\/s10528-023-10612-5","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,4]]},"assertion":[{"value":"25 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"The Ethics Committee of Maternal and Child Health Hospital of Tangshan approved our study protocols. Animal studies were performed with strictness as per the guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}