{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T14:13:07Z","timestamp":1764079987656,"version":"3.29.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s10528-023-10633-0","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T08:02:44Z","timestamp":1707292964000},"page":"4494-4517","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bioinformatics Analysis and Experimental Validation of Differential Genes and Pathways in Bone Nonunions"],"prefix":"10.1007","volume":"62","author":[{"given":"Wei","family":"Xiong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Li","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lv","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Qi","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lang-Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Chen","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"issue":"1","key":"10633_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s13027-023-00525-8","volume":"18","author":"A Alotaibi","year":"2023","unstructured":"Alotaibi A, Gadekar VP, Gundla PS, Mandarthi S, Jayendra N, Tungekar A, Lavanya BV, Bhagavath AK, Cordero MAW, Pitkaniemi J, Niazi SK, Upadhya R, Bepari A, Hebbar P (2023) Global comparative transcriptomes uncover novel and population-specific gene expression in esophageal squamous cell carcinoma. Infect Agents Cancer 18(1):47. https:\/\/doi.org\/10.1186\/s13027-023-00525-8","journal-title":"Infect Agents Cancer"},{"key":"10633_CR2","doi-asserted-by":"publisher","first-page":"727","DOI":"10.3389\/fendo.2019.00727","volume":"10","author":"HR Bender","year":"2019","unstructured":"Bender HR, Campbell GE, Aytoda P, Mathiesen AH, Duffy DM (2019) Thrombospondin 1 (THBS1) promotes follicular angiogenesis, luteinization, and ovulation in primates. Front Endocrinol 10:727. https:\/\/doi.org\/10.3389\/fendo.2019.00727","journal-title":"Front Endocrinol"},{"key":"10633_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010215","author":"F Bonnet-Magnaval","year":"2021","unstructured":"Bonnet-Magnaval F, Diallo LH, Brunchault V, Laugero N, Morfoisse F, David F, Roussel E, Nougue M, Zamora A, Marchaud E, Tatin F, Prats AC, Garmy-Susini B, DesGroseillers L, Lacazette E (2021) High level of staufen1 expression confers longer recurrence free survival to non-small cell lung cancer patients by promoting THBS1 mRNA degradation. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23010215","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10633_CR4","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1302\/0301-620x.97b6.33276","volume":"97-B","author":"D Bose","year":"2015","unstructured":"Bose D, Kugan R, Stubbs D, McNally M (2015) Management of infected nonunion of the long bones by a multidisciplinary team. Bone Joint J 97-B(6):814\u2013817. https:\/\/doi.org\/10.1302\/0301-620x.97b6.33276","journal-title":"Bone Joint J"},{"key":"10633_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering8110167","author":"Y Chen","year":"2021","unstructured":"Chen Y, Menger MM, Braun BJ, Schweizer S, Linnemann C, Falldorf K, Ronniger M, Wang H, Histing T, Nussler AK, Ehnert S (2021) Modulation of macrophage activity by pulsed electromagnetic fields in the context of fracture healing. Bioengineering (Basel, Switzerland). https:\/\/doi.org\/10.3390\/bioengineering8110167","journal-title":"Bioengineering (Basel, Switzerland)"},{"key":"10633_CR6","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3563","author":"L Cheng","year":"2023","unstructured":"Cheng L, Xiong W, Li S, Wang G, Zhou J, Li H (2023) CRISPR-Cas9 screening identified lethal genes enriched in necroptosis pathway and of prognosis significance in osteosarcoma. J Gene Med. https:\/\/doi.org\/10.1002\/jgm.3563","journal-title":"J Gene Med"},{"issue":"3","key":"10633_CR7","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/s41419-019-1428-1","volume":"10","author":"Q Cui","year":"2019","unstructured":"Cui Q, Xing J, Yu M, Wang Y, Xu J, Gu Y, Nan X, Ma W, Liu H, Zhao H (2019) Mmu-miR-185 depletion promotes osteogenic differentiation and suppresses bone loss in osteoporosis through the Bgn-mediated BMP\/Smad pathway. Cell Death Dis 10(3):172. https:\/\/doi.org\/10.1038\/s41419-019-1428-1","journal-title":"Cell Death Dis"},{"issue":"Suppl 1","key":"10633_CR8","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1016\/j.injury.2017.04.020","volume":"48","author":"BP Cunningham","year":"2017","unstructured":"Cunningham BP, Brazina S, Morshed S, Miclau T 3rd (2017) Fracture healing: a review of clinical, imaging and laboratory diagnostic options. Injury 48(Suppl 1):S69\u2013S75. https:\/\/doi.org\/10.1016\/j.injury.2017.04.020","journal-title":"Injury"},{"key":"10633_CR9","doi-asserted-by":"publisher","first-page":"6412760","DOI":"10.1155\/2018\/6412760","volume":"2018","author":"MJ DeRogatis","year":"2018","unstructured":"DeRogatis MJ, Issack PS (2018) Use of the pelvic C-clamp to mitigate acute respiratory distress syndrome in a patient with an unstable sacral fracture. Case Rep Orthop 2018:6412760. https:\/\/doi.org\/10.1155\/2018\/6412760","journal-title":"Case Rep Orthop"},{"key":"10633_CR10","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jot.2018.05.002","volume":"14","author":"ZC Ding","year":"2018","unstructured":"Ding ZC, Lin YK, Gan YK, Tang TT (2018) Molecular pathogenesis of fracture nonunion. J Orthop Transl 14:45\u201356. https:\/\/doi.org\/10.1016\/j.jot.2018.05.002","journal-title":"J Orthop Transl"},{"issue":"9","key":"10633_CR11","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1002\/term.2732","volume":"12","author":"B Dozza","year":"2018","unstructured":"Dozza B, Salamanna F, Baleani M, Giavaresi G, Parrilli A, Zani L, Lucarelli E, Martini L, Fini M, Donati DM (2018) Nonunion fracture healing: evaluation of effectiveness of demineralized bone matrix and mesenchymal stem cells in a novel sheep bone nonunion model. J Tissue Eng Regen Med 12(9):1972\u20131985. https:\/\/doi.org\/10.1002\/term.2732","journal-title":"J Tissue Eng Regen Med"},{"issue":"7","key":"10633_CR12","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1302\/0301-620x.98b7.36061","volume":"98-B","author":"DS Elliott","year":"2016","unstructured":"Elliott DS, Newman KJ, Forward DP, Hahn DM, Ollivere B, Kojima K, Handley R, Rossiter ND, Wixted JJ, Smith RM, Moran CG (2016) A unified theory of bone healing and nonunion: BHN theory. Bone Joint J 98-B(7):884\u2013891. https:\/\/doi.org\/10.1302\/0301-620x.98b7.36061","journal-title":"Bone Joint J"},{"issue":"12","key":"10633_CR13","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1016\/j.injury.2018.09.024","volume":"49","author":"L Fader","year":"2018","unstructured":"Fader L, Whitaker J, Lopez M, Vivace B, Parra M, Carlson J, Zamora R (2018) Tibia fractures and NSAIDs Does it make a difference? A multicenter retrospective study. Injury 49(12):2290\u20132294. https:\/\/doi.org\/10.1016\/j.injury.2018.09.024","journal-title":"Injury"},{"key":"10633_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neulet.2015.02.002","volume":"591","author":"N Feng","year":"2015","unstructured":"Feng N, Wang Z, Zhang Z, He X, Wang C, Zhang L (2015) miR-487b promotes human umbilical vein endothelial cell proliferation, migration, invasion and tube formation through regulating THBS1. Neurosci Lett 591:1\u20137. https:\/\/doi.org\/10.1016\/j.neulet.2015.02.002","journal-title":"Neurosci Lett"},{"issue":"1","key":"10633_CR15","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.immuni.2017.12.007","volume":"48","author":"A Glasner","year":"2018","unstructured":"Glasner A, Levi A, Enk J, Isaacson B, Viukov S, Orlanski S, Scope A, Neuman T, Enk CD, Hanna JH, Sexl V, Jonjic S, Seliger B, Zitvogel L, Mandelboim O (2018) NKp46 receptor-mediated interferon-\u03b3 production by natural killer cells increases fibronectin 1 to alter tumor architecture and control metastasis. Immunity 48(1):107-119.e104. https:\/\/doi.org\/10.1016\/j.immuni.2017.12.007","journal-title":"Immunity"},{"key":"10633_CR16","doi-asserted-by":"publisher","first-page":"924927","DOI":"10.3389\/fendo.2022.924927","volume":"13","author":"LH Goodnough","year":"2022","unstructured":"Goodnough LH, Ambrosi TH, Steininger HM, Butler MGK, Hoover MY, Choo H, Van Rysselberghe NL, Bellino MJ, Bishop JA, Gardner MJ, Chan CKF (2022) Cross-species comparisons reveal resistance of human skeletal stem cells to inhibition by non-steroidal anti-inflammatory drugs. Front Endocrinol 13:924927. https:\/\/doi.org\/10.3389\/fendo.2022.924927","journal-title":"Front Endocrinol"},{"issue":"Suppl 2","key":"10633_CR17","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.injury.2014.04.002","volume":"45","author":"DJ Hak","year":"2014","unstructured":"Hak DJ, Fitzpatrick D, Bishop JA, Marsh JL, Tilp S, Schnettler R, Simpson H, Alt V (2014) Delayed union and nonunions: epidemiology, clinical issues, and financial aspects. Injury 45(Suppl 2):S3-7. https:\/\/doi.org\/10.1016\/j.injury.2014.04.002","journal-title":"Injury"},{"issue":"2","key":"10633_CR18","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1002\/iid3.414","volume":"9","author":"X-Y Huang","year":"2021","unstructured":"Huang X-Y, Liu J-J, Liu X, Wang Y-H, Xiang W (2021) Bioinformatics analysis of the prognosis and biological significance of VCAN in gastric cancer. Immun Inflamm Dis 9(2):547\u2013559. https:\/\/doi.org\/10.1002\/iid3.414","journal-title":"Immun Inflamm Dis"},{"key":"10633_CR19","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.3590","author":"L Huang","year":"2023","unstructured":"Huang L, Xiong W, Cheng L, Li H (2023) Bioinformatics-based analysis of programmed cell death pathway and key prognostic genes in gastric cancer: implications for the development of therapeutics. J Gene Med. https:\/\/doi.org\/10.1002\/jgm.3590","journal-title":"J Gene Med"},{"key":"10633_CR20","doi-asserted-by":"publisher","first-page":"101657","DOI":"10.1016\/j.bonr.2023.101657","volume":"18","author":"AI Hussein","year":"2023","unstructured":"Hussein AI, Carroll D, Bui M, Wolff A, Matheny H, Hogue B, Lybrand K, Cooke M, Bragdon B, Morgan E, Demissie S, Gerstenfeld L (2023) Oxidative metabolism is impaired by phosphate deficiency during fracture healing and is mechanistically related to BMP induced chondrocyte differentiation. Bone Rep 18:101657. https:\/\/doi.org\/10.1016\/j.bonr.2023.101657","journal-title":"Bone Rep"},{"issue":"1","key":"10633_CR21","doi-asserted-by":"publisher","first-page":"149","DOI":"10.2174\/1386207325666220412134311","volume":"26","author":"TM Jiang","year":"2023","unstructured":"Jiang TM (2023) Unveiling the time course mechanism of bone fracture healing by transcriptional profiles. Comb Chem High Throughput Screen 26(1):149\u2013162. https:\/\/doi.org\/10.2174\/1386207325666220412134311","journal-title":"Comb Chem High Throughput Screen"},{"issue":"8","key":"10633_CR22","doi-asserted-by":"publisher","first-page":"4095","DOI":"10.26355\/eurrev_202004_20987","volume":"24","author":"SL Jin","year":"2020","unstructured":"Jin SL, Bai YM, Zhao BY, Wang QH, Zhang HS (2020) Silencing of miR-330\u20135p stimulates osteogenesis in bone marrow mesenchymal stem cells and inhibits bone loss in osteoporosis by activating Bgn-mediated BMP\/Smad pathway. Eur Rev Med Pharmacol Sci 24(8):4095\u20134102. https:\/\/doi.org\/10.26355\/eurrev_202004_20987","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10633_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/life12050726","author":"M Johansson","year":"2022","unstructured":"Johansson M, Tangruksa B, Heydarkhan-Hagvall S, Jeppsson A, Sartipy P, Synnergren J (2022) Data mining identifies CCN2 and THBS1 as biomarker candidates for cardiac hypertrophy. Life (Basel, Switzerland). https:\/\/doi.org\/10.3390\/life12050726","journal-title":"Life (Basel, Switzerland)"},{"key":"10633_CR24","doi-asserted-by":"publisher","first-page":"692216","DOI":"10.3389\/fimmu.2021.692216","volume":"12","author":"J Kiripolsky","year":"2021","unstructured":"Kiripolsky J, Kasperek EM, Zhu C, Li QZ, Wang J, Yu G, Kramer JM (2021) Immune-intrinsic Myd88 directs the production of antibodies with specificity for extracellular matrix components in primary sj\u00f6gren\u2019s syndrome. Front Immunol 12:692216. https:\/\/doi.org\/10.3389\/fimmu.2021.692216","journal-title":"Front Immunol"},{"key":"10633_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207513","author":"T Komori","year":"2020","unstructured":"Komori T (2020) Functions of osteocalcin in bone pancreas, testis, and muscle. . Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21207513","journal-title":". Int J Mol Sci"},{"issue":"6","key":"10633_CR26","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1002\/hep.31614","volume":"73","author":"MS Krishnan","year":"2021","unstructured":"Krishnan MS, Rajan KdA, Park J, Arjunan V, Garcia Marques FJ, Bermudez A, Girvan OA, Hoang NS, Yin J, Nguyen MH, Kothary N, Pitteri S, Felsher DW, Dhanasekaran R (2021) Genomic analysis of vascular invasion in HCC reveals molecular drivers and predictive biomarkers. Hepatology (Baltimore, MD) 73(6):2342\u20132360. https:\/\/doi.org\/10.1002\/hep.31614","journal-title":"Hepatology (Baltimore, MD)"},{"issue":"14","key":"10633_CR27","doi-asserted-by":"publisher","first-page":"6502","DOI":"10.1039\/d0fo03069d","volume":"12","author":"Z Li","year":"2021","unstructured":"Li Z, Tian Y, Zhang L, Zhang T, Wang P, Wang J (2021) Type II collagen from squid cartilage mediated myogenic IGF-I and Irisin to activate the Ihh\/PThrp and Wnt\/\u03b2-catenin pathways to promote fracture healing in mice. Food Funct 12(14):6502\u20136512. https:\/\/doi.org\/10.1039\/d0fo03069d","journal-title":"Food Funct"},{"key":"10633_CR28","doi-asserted-by":"publisher","first-page":"101617","DOI":"10.1016\/j.molmet.2022.101617","volume":"66","author":"H Li","year":"2022","unstructured":"Li H, Yuan Y, Chen H, Dai H, Li J (2022) Indoleamine 2,3-dioxygenase mediates the therapeutic effects of adipose-derived stromal\/stem cells in experimental periodontitis by modulating macrophages through the kynurenine-AhR-NRF2 pathway. Mol Metab 66:101617. https:\/\/doi.org\/10.1016\/j.molmet.2022.101617","journal-title":"Mol Metab"},{"issue":"6","key":"10633_CR29","first-page":"464","volume":"53","author":"J Liu","year":"2015","unstructured":"Liu J, Zhang L, Tang P (2015) Diagnosis and treatment of fracture delayed union and nonunion. Zhonghua Wai Ke Za Zhi [Chin J Surg] 53(6):464\u2013467","journal-title":"Zhonghua Wai Ke Za Zhi [Chin J Surg]"},{"issue":"10","key":"10633_CR30","doi-asserted-by":"publisher","first-page":"e13298","DOI":"10.1111\/cpr.13298","volume":"55","author":"G Liu","year":"2022","unstructured":"Liu G, Yang G, Zhao G, Guo C, Zeng Y, Xue Y, Zeng F (2022) Spatial transcriptomic profiling to identify mesoderm progenitors with precision genomic screening and functional confirmation. Cell Prolif 55(10):e13298. https:\/\/doi.org\/10.1111\/cpr.13298","journal-title":"Cell Prolif"},{"issue":"3","key":"10633_CR31","doi-asserted-by":"publisher","first-page":"436","DOI":"10.3892\/etm.2023.12135","volume":"26","author":"Y Liu","year":"2023","unstructured":"Liu Y, Wang W, Zeng Y, Zeng H (2023) Transcriptome analysis of hydrogen inhibits osteoclastogenesis of mouse bone marrow mononuclear cells. Exp Ther Med 26(3):436. https:\/\/doi.org\/10.3892\/etm.2023.12135","journal-title":"Exp Ther Med"},{"key":"10633_CR32","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.arr.2018.04.003","volume":"45","author":"M Majidinia","year":"2018","unstructured":"Majidinia M, Reiter RJ, Shakouri SK, Mohebbi I, Rastegar M, Kaviani M, Darband SG, Jahanban-Esfahlan R, Nabavi SM, Yousefi B (2018) The multiple functions of melatonin in regenerative medicine. Ageing Res Rev 45:33\u201352. https:\/\/doi.org\/10.1016\/j.arr.2018.04.003","journal-title":"Ageing Res Rev"},{"issue":"4","key":"10633_CR33","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/s41419-023-05788-y","volume":"14","author":"XG Mao","year":"2023","unstructured":"Mao XG, Xue XY, Lv R, Ji A, Shi TY, Chen XY, Jiang XF, Zhang X (2023) CEBPD is a master transcriptional factor for hypoxia regulated proteins in glioblastoma and augments hypoxia induced invasion through extracellular matrix-integrin mediated EGFR\/PI3K pathway. Cell Death Dis 14(4):269. https:\/\/doi.org\/10.1038\/s41419-023-05788-y","journal-title":"Cell Death Dis"},{"issue":"1","key":"10633_CR34","doi-asserted-by":"publisher","first-page":"e41","DOI":"10.1016\/j.athoracsur.2020.05.026","volume":"111","author":"F Marin","year":"2021","unstructured":"Marin F (2021) Treatment of Chronic nonunion of a sternal fracture with teriparatide. Ann Thorac Surg 111(1):e41\u2013e42. https:\/\/doi.org\/10.1016\/j.athoracsur.2020.05.026","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"10633_CR35","doi-asserted-by":"publisher","first-page":"6889","DOI":"10.1038\/s41467-022-34604-y","volume":"13","author":"DK Maurya","year":"2022","unstructured":"Maurya DK, Berghard A, Bohm S (2022) A multivesicular body-like organelle mediates stimulus-regulated trafficking of olfactory ciliary transduction proteins. Nat Commun 13(1):6889. https:\/\/doi.org\/10.1038\/s41467-022-34604-y","journal-title":"Nat Commun"},{"issue":"Suppl 6","key":"10633_CR36","doi-asserted-by":"publisher","first-page":"S25","DOI":"10.1097\/bot.0000000000001468","volume":"33","author":"TO McKinley","year":"2019","unstructured":"McKinley TO, Lisboa FA, Horan AD, Gaski GE, Mehta S (2019) Precision medicine applications to manage multiply injured patients with orthopaedic Trauma. J Orthop Trauma 33(Suppl 6):S25\u2013S29. https:\/\/doi.org\/10.1097\/bot.0000000000001468","journal-title":"J Orthop Trauma"},{"key":"10633_CR37","unstructured":"Memeo A, Verdoni F, Minoli CF, Voto A, D'Amato RD, Formiconi F, Priano D, Montanari L, Panuccio E. (2020) Effectiveness of bone marrow aspirate concentrate (BMAC) as adjuvant therapy in the surgical treatment of congenital pseudoarthrosis of the tibia: a retrospective comparative study. 34(4 Suppl. 3):431\u2013440. Congress of the Italian Orthopaedic Research Society"},{"issue":"3","key":"10633_CR38","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1055\/s-0041-1740380","volume":"26","author":"P Mick","year":"2022","unstructured":"Mick P, Fischer C (2022) Delayed fracture healing. Semin Musculoskelet Radiol 26(3):329\u2013337. https:\/\/doi.org\/10.1055\/s-0041-1740380","journal-title":"Semin Musculoskelet Radiol"},{"key":"10633_CR39","doi-asserted-by":"publisher","first-page":"950030","DOI":"10.3389\/fendo.2022.950030","volume":"13","author":"L Mo","year":"2022","unstructured":"Mo L, Ma C, Wang Z, Li J, He W, Niu W, Chen Z, Zhou C, Liu Y (2022) Integrated bioinformatic analysis of the shared molecular mechanisms between osteoporosis and atherosclerosis. Front Endocrinol 13:950030. https:\/\/doi.org\/10.3389\/fendo.2022.950030","journal-title":"Front Endocrinol"},{"key":"10633_CR40","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.matbio.2016.03.008","volume":"52\u201354","author":"M Myren","year":"2016","unstructured":"Myren M, Kirby DJ, Noonan ML, Maeda A, Owens RT, Ricard-Blum S, Kram V, Kilts TM, Young MF (2016) Biglycan potentially regulates angiogenesis during fracture repair by altering expression and function of endostatin. Matrix Biol: J Int Soc Matrix Biol 52\u201354:141\u2013150. https:\/\/doi.org\/10.1016\/j.matbio.2016.03.008","journal-title":"Matrix Biol: J Int Soc Matrix Biol"},{"issue":"Suppl 2","key":"10633_CR41","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.injury.2020.11.029","volume":"52","author":"JA Nicholson","year":"2021","unstructured":"Nicholson JA, Makaram N, Simpson A, Keating JF (2021) Fracture nonunion in long bones: a literature review of risk factors and surgical management. Injury 52(Suppl 2):S3\u2013S11. https:\/\/doi.org\/10.1016\/j.injury.2020.11.029","journal-title":"Injury"},{"issue":"1","key":"10633_CR42","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1007\/s00776-013-0472-4","volume":"19","author":"T Niikura","year":"2014","unstructured":"Niikura T, Lee SY, Sakai Y, Nishida K, Kuroda R, Kurosaka M (2014) Causative factors of fracture nonunion: the proportions of mechanical, biological, patient-dependent, and patient-independent factors. J Orthop Sci\u202f: Off J Jpn Orthop Assoc 19(1):120\u2013124. https:\/\/doi.org\/10.1007\/s00776-013-0472-4","journal-title":"J Orthop Sci : Off J Jpn Orthop Assoc"},{"issue":"1","key":"10633_CR43","doi-asserted-by":"publisher","first-page":"5534","DOI":"10.1038\/s41467-023-41095-y","volume":"14","author":"M Omatsu","year":"2023","unstructured":"Omatsu M, Nakanishi Y, Iwane K, Aoyama N, Duran A, Muta Y, Martinez-Ordo\u00f1ez A, Han Q, Agatsuma N, Mizukoshi K, Kawai M, Yamakawa G, Namikawa M, Hamada K, Fukunaga Y, Utsumi T, Sono M, Masuda T, Hata A, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Tsuda M, Maruno T, Kogame T, Kasashima H, Kakiuchi N, Nakagawa MM, Kawada K, Yashiro M, Maeda K, Saito Y, Matozaki T, Fukuda A, Kabashima K, Obama K, Ogawa S, Sheibani N, Diaz-Meco MT, Moscat J, Seno H (2023) THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer. Nat Commun 14(1):5534. https:\/\/doi.org\/10.1038\/s41467-023-41095-y","journal-title":"Nat Commun"},{"issue":"2","key":"10633_CR44","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/path.5985","volume":"258","author":"F Pagano","year":"2022","unstructured":"Pagano F, Picchio V, Bordin A, Cavarretta E, Nocella C, Cozzolino C, Floris E, Angelini F, Sordano A, Peruzzi M, Miraldi F, Biondi-Zoccai G, De Falco E, Carnevale R, Sciarretta S, Frati G, Chimenti I (2022) Progressive stages of dysmetabolism are associated with impaired biological features of human cardiac stromal cells mediated by the oxidative state and autophagy. J Pathol 258(2):136\u2013148. https:\/\/doi.org\/10.1002\/path.5985","journal-title":"J Pathol"},{"key":"10633_CR45","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2021.40.93.28184","author":"P Palaniappan","year":"2021","unstructured":"Palaniappan P, Baalann KP (2021) Fracture nonunion. Pan Afri Med J. https:\/\/doi.org\/10.11604\/pamj.2021.40.93.28184","journal-title":"Pan Afri Med J"},{"issue":"7","key":"10633_CR46","doi-asserted-by":"publisher","first-page":"4431","DOI":"10.1007\/s12035-015-9378-9","volume":"53","author":"Y Pan","year":"2016","unstructured":"Pan Y, Zhang Y, Chen L, Liu Y, Feng Y, Yan J (2016) The critical role of Rab31 in cell proliferation and apoptosis in cancer progression. Mol Neurobiol 53(7):4431\u20134437. https:\/\/doi.org\/10.1007\/s12035-015-9378-9","journal-title":"Mol Neurobiol"},{"issue":"6","key":"10633_CR47","doi-asserted-by":"publisher","first-page":"355","DOI":"10.55095\/achot2014\/049","volume":"81","author":"SM Perren","year":"2014","unstructured":"Perren SM (2014) Fracture healing: fracture healing understood as the result of a fascinating cascade of physical and biological interactions. Part I. An attempt to integrate observations from 30\u00a0years AO research. Acta Chirurgiae Orthop et Traumatol Cechoslov 81(6):355\u2013364","journal-title":"Acta Chirurgiae Orthop et Traumatol Cechoslov"},{"issue":"1","key":"10633_CR48","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/s41467-020-15002-8","volume":"11","author":"LI Rathbun","year":"2020","unstructured":"Rathbun LI, Colicino EG, Manikas J, O\u2019Connell J, Krishnan N, Reilly NS, Coyne S, Erdemci-Tandogan G, Garrastegui A, Freshour J, Santra P, Manning ML, Amack JD, Hehnly H (2020) Cytokinetic bridge triggers de novo lumen formation in vivo. Nat Commun 11(1):1269. https:\/\/doi.org\/10.1038\/s41467-020-15002-8","journal-title":"Nat Commun"},{"issue":"2","key":"10633_CR49","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cell.2013.09.032","volume":"155","author":"I Rodriguez","year":"2013","unstructured":"Rodriguez I (2013) Singular expression of olfactory receptor genes. Cell 155(2):274\u2013277. https:\/\/doi.org\/10.1016\/j.cell.2013.09.032","journal-title":"Cell"},{"key":"10633_CR50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094823","author":"T Sakai","year":"2022","unstructured":"Sakai T, Choo YY, Sato O, Ikebe R, Jeffers A, Idell S, Tucker T, Ikebe M (2022) Myo5b transports fibronectin-containing vesicles and facilitates FN1 secretion from human pleural mesothelial cells. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23094823","journal-title":"Int J Mol Sci"},{"key":"10633_CR51","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.bone.2015.05.025","volume":"80","author":"G S\u00e1nchez-Duffhues","year":"2015","unstructured":"S\u00e1nchez-Duffhues G, Hiepen C, Knaus P, Ten Dijke P (2015) Bone morphogenetic protein signaling in bone homeostasis. Bone 80:43\u201359. https:\/\/doi.org\/10.1016\/j.bone.2015.05.025","journal-title":"Bone"},{"issue":"2","key":"10633_CR52","doi-asserted-by":"publisher","first-page":"158545","DOI":"10.1016\/j.bbalip.2019.158545","volume":"1865","author":"M Scuruchi","year":"2020","unstructured":"Scuruchi M, Pot\u00ec F, Rodr\u00edguez-Carrio J, Campo GM, Mandraffino G (2020) Biglycan and atherosclerosis: lessons from high cardiovascular risk conditions. Biochim Biophys Acta 1865(2):158545. https:\/\/doi.org\/10.1016\/j.bbalip.2019.158545","journal-title":"Biochim Biophys Acta"},{"key":"10633_CR53","doi-asserted-by":"publisher","first-page":"1119368","DOI":"10.3389\/fphys.2023.1119368","volume":"14","author":"R Shainer","year":"2023","unstructured":"Shainer R, Kram V, Kilts TM, Li L, Doyle AD, Shainer I, Martin D, Simon CG Jr, Zeng-Brouwers J, Schaefer L, Young MF (2023) Biglycan regulates bone development and regeneration. Front Physiol 14:1119368. https:\/\/doi.org\/10.3389\/fphys.2023.1119368","journal-title":"Front Physiol"},{"key":"10633_CR54","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.biomaterials.2018.06.005","volume":"198","author":"YV Shih","year":"2019","unstructured":"Shih YV, Varghese S (2019) Tissue engineered bone mimetics to study bone disorders ex vivo: role of bioinspired materials. Biomaterials 198:107\u2013121. https:\/\/doi.org\/10.1016\/j.biomaterials.2018.06.005","journal-title":"Biomaterials"},{"issue":"6","key":"10633_CR55","first-page":"1728","volume":"10","author":"HJ Shih","year":"2020","unstructured":"Shih HJ, Chen CL, Torng PL (2020) IGFBP3 inhibits angiogenesis through intracellular regulation of THBS1 expression. Am J Cancer Res 10(6):1728\u20131744","journal-title":"Am J Cancer Res"},{"key":"10633_CR56","doi-asserted-by":"publisher","first-page":"963689723118353","DOI":"10.1177\/09636897231183530","volume":"32","author":"V Smolinska","year":"2023","unstructured":"Smolinska V, Csobonyeiova M, Zamborsky R, Danisovic L (2023) Stem cells and their derivatives: an implication for the regeneration of nonunion fractures. Cell Transpl 32:9636897231183530. https:\/\/doi.org\/10.1177\/09636897231183530","journal-title":"Cell Transpl"},{"key":"10633_CR57","doi-asserted-by":"publisher","first-page":"117693512211262","DOI":"10.1177\/11769351221126285","volume":"21","author":"Y Sun","year":"2022","unstructured":"Sun Y, Zhao J (2022) Transcription elongation factor A (SII)-Like (TCEAL) gene family member-TCEAL2: a novel prognostic marker in pan-cancer. Cancer Inform 21:11769351221126284. https:\/\/doi.org\/10.1177\/11769351221126285","journal-title":"Cancer Inform"},{"issue":"3","key":"10633_CR58","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1093\/humrep\/deab266","volume":"37","author":"SG Sun","year":"2022","unstructured":"Sun SG, Guo JJ, Qu XY, Tang XY, Lin YY, Hua KQ, Qiu JJ (2022) The extracellular vesicular pseudogene LGMNP1 induces M2-like macrophage polarization by upregulating LGMN and serves as a novel promising predictive biomarker for ovarian endometriosis recurrence. Hum Reprod 37(3):447\u2013465. https:\/\/doi.org\/10.1093\/humrep\/deab266","journal-title":"Hum Reprod"},{"key":"10633_CR59","unstructured":"Swieboda P, Filip R, Prystupa A, Drozd M. (2013) Assessment of pain: types, mechanism and treatment. Spec no. 1:2\u20137"},{"issue":"4","key":"10633_CR60","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1161\/circulationaha.119.041231","volume":"142","author":"X Tang","year":"2020","unstructured":"Tang X, Miao Y, Luo Y, Sriram K, Qi Z, Lin FM, Gu Y, Lai CH, Hsu CY, Peterson KL, Van Keuren-Jensen K, Fueger PT, Yeo GW, Natarajan R, Zhong S, Chen ZB (2020) Suppression of endothelial AGO1 promotes adipose tissue browning and improves metabolic dysfunction. Circulation 142(4):365\u2013379. https:\/\/doi.org\/10.1161\/circulationaha.119.041231","journal-title":"Circulation"},{"issue":"5","key":"10633_CR61","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.tcb.2022.08.007","volume":"33","author":"SM Troyanovsky","year":"2023","unstructured":"Troyanovsky SM (2023) Adherens junction: the ensemble of specialized cadherin clusters. Trends Cell Biol 33(5):374\u2013387. https:\/\/doi.org\/10.1016\/j.tcb.2022.08.007","journal-title":"Trends Cell Biol"},{"issue":"1","key":"10633_CR62","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1242\/dev.125286","volume":"143","author":"X Wang","year":"2016","unstructured":"Wang X, Astrof S (2016) Neural crest cell-autonomous roles of fibronectin in cardiovascular development. Development (Cambridge, England) 143(1):88\u2013100. https:\/\/doi.org\/10.1242\/dev.125286","journal-title":"Development (Cambridge, England)"},{"issue":"3","key":"10633_CR63","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.1161\/circresaha.120.318200","volume":"128","author":"M Warkala","year":"2021","unstructured":"Warkala M, Chen D, Ramirez A, Jubran A, Schonning M, Wang X, Zhao H, Astrof S (2021) Cell-extracellular matrix interactions play multiple essential roles in aortic arch development. Circ Res 128(3):e27\u2013e44. https:\/\/doi.org\/10.1161\/circresaha.120.318200","journal-title":"Circ Res"},{"issue":"1","key":"10633_CR64","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41572-021-00289-8","volume":"7","author":"B Wildemann","year":"2021","unstructured":"Wildemann B, Ignatius A, Leung F, Taitsman LA, Smith RM, Pes\u00e1ntez R, Stoddart MJ, Richards RG, Jupiter JB (2021) Non-union bone fractures. Nat Rev Dis Primers 7(1):57. https:\/\/doi.org\/10.1038\/s41572-021-00289-8","journal-title":"Nat Rev Dis Primers"},{"key":"10633_CR65","doi-asserted-by":"publisher","first-page":"121741","DOI":"10.1016\/j.biomaterials.2022.121741","volume":"288","author":"C Xie","year":"2022","unstructured":"Xie C, Liang R, Ye J, Peng Z, Sun H, Zhu Q, Shen X, Hong Y, Wu H, Sun W, Yao X, Li J, Zhang S, Zhang X, Ouyang H (2022) High-efficient engineering of osteo-callus organoids for rapid bone regeneration within one month. Biomaterials 288:121741. https:\/\/doi.org\/10.1016\/j.biomaterials.2022.121741","journal-title":"Biomaterials"},{"key":"10633_CR66","doi-asserted-by":"publisher","first-page":"144766","DOI":"10.1016\/j.gene.2020.144766","volume":"751","author":"T Yan","year":"2020","unstructured":"Yan T, Li J, Zhou X, Yang Z, Zhang Y, Zhang J, Xu N, Huang Y, Yang H (2020) Genetic determinants of fracture non-union: a systematic review from the literature. Gene 751:144766. https:\/\/doi.org\/10.1016\/j.gene.2020.144766","journal-title":"Gene"},{"issue":"1","key":"10633_CR67","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1186\/s12885-020-07393-0","volume":"20","author":"J Yang","year":"2020","unstructured":"Yang J, Wang F, Chen B (2020) HLA-DPA1 gene is a potential predictor with prognostic values in multiple myeloma. BMC Cancer 20(1):915. https:\/\/doi.org\/10.1186\/s12885-020-07393-0","journal-title":"BMC Cancer"},{"key":"10633_CR68","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.2147\/ott.S282947","volume":"14","author":"Y Yang","year":"2021","unstructured":"Yang Y, Wang R, Feng L, Ma H, Fang J (2021) LINC00460 promotes cell proliferation, migration, invasion, and epithelial-mesenchymal transition of head and neck squamous cell carcinoma via miR-320a\/BGN Axis. OncoTargets Therapy 14:2279\u20132291. https:\/\/doi.org\/10.2147\/ott.S282947","journal-title":"OncoTargets Therapy"},{"issue":"10","key":"10633_CR69","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/s41419-021-04225-2","volume":"12","author":"H Yao","year":"2021","unstructured":"Yao H, Liu J, Zhang C, Shao Y, Li X, Yu Z, Huang Y (2021) Apatinib inhibits glioma cell malignancy in patient-derived orthotopic xenograft mouse model by targeting thrombospondin 1\/myosin heavy chain 9 axis. Cell Death Dis 12(10):927. https:\/\/doi.org\/10.1038\/s41419-021-04225-2","journal-title":"Cell Death Dis"},{"issue":"2","key":"10633_CR70","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1111\/liv.15477","volume":"43","author":"M Yu","year":"2023","unstructured":"Yu M, He X, Song X, Gao J, Pan J, Zhou T, Wang Q, Zhu W, Ma H, Zeng H, Xu C, Yu C (2023) Biglycan promotes hepatic fibrosis through activating heat shock protein 47. Liver Int: Off J Int Assoc Study Liver 43(2):500\u2013512. https:\/\/doi.org\/10.1111\/liv.15477","journal-title":"Liver Int: Off J Int Assoc Study Liver"},{"key":"10633_CR71","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2022.12618","author":"J Zhai","year":"2022","unstructured":"Zhai J, Luo G (2022) GATA6-induced FN1 activation promotes the proliferation, invasion and migration of oral squamous cell carcinoma cells. Mol Med Rep. https:\/\/doi.org\/10.3892\/mmr.2022.12618","journal-title":"Mol Med Rep"},{"key":"10633_CR72","doi-asserted-by":"publisher","first-page":"145253","DOI":"10.1016\/j.gene.2020.145253","volume":"769","author":"H Zhang","year":"2021","unstructured":"Zhang H, Chen X, Xue P, Ma X, Li J, Zhang J (2021) FN1 promotes chondrocyte differentiation and collagen production via TGF-\u03b2\/PI3K\/Akt pathway in mice with femoral fracture. Gene 769:145253. https:\/\/doi.org\/10.1016\/j.gene.2020.145253","journal-title":"Gene"},{"issue":"1","key":"10633_CR73","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/1873-3468.13291","volume":"593","author":"Q Zhu","year":"2019","unstructured":"Zhu Q, Guo W, Zhang S, Feng Y, Wang X, Zhou L, Huang G-R (2019) Synergistic effect of PCPE1 and sFRP2 on the processing of procollagens via BMP1. FEBS Lett 593(1):119\u2013127. https:\/\/doi.org\/10.1002\/1873-3468.13291","journal-title":"FEBS Lett"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-023-10633-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-023-10633-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-023-10633-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T14:08:59Z","timestamp":1732802939000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10528-023-10633-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,7]]},"references-count":73,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10633"],"URL":"https:\/\/doi.org\/10.1007\/s10528-023-10633-0","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"type":"print","value":"0006-2928"},{"type":"electronic","value":"1573-4927"}],"subject":[],"published":{"date-parts":[[2024,2,7]]},"assertion":[{"value":"20 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval and Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}