{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T18:07:06Z","timestamp":1762625226408,"version":"3.40.2"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s10528-024-10753-1","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T10:02:02Z","timestamp":1711447322000},"page":"1241-1257","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Hsa_circ_0105558\/miR-182-5p\/ATF6 Cascade Affects H2O2-Triggered Oxidative Damage and Apoptosis of Human Lens Epithelial Cells"],"prefix":"10.1007","volume":"63","author":[{"given":"Wei","family":"Mao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"10753_CR1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1080\/09674845.2019.1639337","volume":"76","author":"OA Abdullah","year":"2019","unstructured":"Abdullah OA, El Gazzar WB, Salem TI, Elmohamady MN, Nasif SN, Eltaher SM (2019) miR-15a: a potential diagnostic biomarker and a candidate for non-operative therapeutic modality for age-related cataract. Br J Biomed Sci 76:184\u2013189","journal-title":"Br J Biomed Sci"},{"key":"10753_CR2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/ceo.13892","volume":"49","author":"MJ Ang","year":"2021","unstructured":"Ang MJ, Afshari NA (2021) Cataract and systemic disease: a review. Clin Exp Ophthalmol 49:118\u2013127","journal-title":"Clin Exp Ophthalmol"},{"key":"10753_CR3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cellsig.2018.01.004","volume":"44","author":"MD Bright","year":"2018","unstructured":"Bright MD, Clarke PA, Workman P, Davies FE (2018) Oncogenic RAC1 and NRAS drive resistance to endoplasmic reticulum stress through MEK\/ERK signalling. Cell Signal 44:127\u2013137","journal-title":"Cell Signal"},{"key":"10753_CR4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13045-018-0555-y","volume":"11","author":"MQ Cao","year":"2018","unstructured":"Cao MQ, You AB, Zhu XD et al (2018) miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a. J Hematol Oncol 11:12","journal-title":"J Hematol Oncol"},{"key":"10753_CR5","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1080\/02713683.2021.1900273","volume":"46","author":"Y Cao","year":"2021","unstructured":"Cao Y, Li P, Zhang G et al (2021) MicroRNA Let-7c-5p-mediated regulation of ERCC6 disrupts autophagic flux in age-related cataract via the binding to VCP. Curr Eye Res 46:1353\u20131362","journal-title":"Curr Eye Res"},{"key":"10753_CR6","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1113\/JP281994","volume":"599","author":"N Capatina","year":"2021","unstructured":"Capatina N, Hemberger M, Burton GJ, Watson ED, Yung HW (2021) Excessive endoplasmic reticulum stress drives aberrant mouse trophoblast differentiation and placental development leading to pregnancy loss. J Physiol 599:4153\u20134181","journal-title":"J Physiol"},{"key":"10753_CR7","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1093\/bib\/bbaa001","volume":"22","author":"L Chen","year":"2021","unstructured":"Chen L, Wang C, Sun H et al (2021) The bioinformatics toolbox for circRNA discovery and analysis. Brief Bioinform 22:1706\u20131728","journal-title":"Brief Bioinform"},{"key":"10753_CR8","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108230","volume":"200","author":"PS Chitra","year":"2020","unstructured":"Chitra PS, Chaki D, Boiroju NK et al (2020) Status of oxidative stress markers, advanced glycation index, and polyol pathway in age-related cataract subjects with and without diabetes. Exp Eye Res 200:108230","journal-title":"Exp Eye Res"},{"key":"10753_CR9","doi-asserted-by":"crossref","first-page":"374","DOI":"10.18240\/ijo.2020.03.02","volume":"13","author":"YL Cui","year":"2020","unstructured":"Cui YL, Yu XN, Zhang X et al (2020) Association of IGF1R polymorphisms (rs1546713) with susceptibility to age-related cataract in a Han Chinese population. Int J Ophthalmol 13:374\u2013381","journal-title":"Int J Ophthalmol"},{"key":"10753_CR10","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/s41419-020-03135-z","volume":"11","author":"C Ding","year":"2020","unstructured":"Ding C, Ding X, Zheng J et al (2020) miR-182-5p and miR-378a-3p regulate ferroptosis in I\/R-triggered renal injury. Cell Death Dis 11:929","journal-title":"Cell Death Dis"},{"key":"10753_CR11","doi-asserted-by":"crossref","first-page":"e1701","DOI":"10.1002\/wrna.1701","volume":"13","author":"PM Fr\u00e9d\u00e9rick","year":"2021","unstructured":"Fr\u00e9d\u00e9rick PM, Simard MJ (2021) Regulation and different functions of the animal microRNA-triggered silencing complex. Wiley Interdiscip Rev RNA 13:e1701","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"10753_CR12","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/s41433-020-0806-3","volume":"34","author":"H Hashemi","year":"2020","unstructured":"Hashemi H, Pakzad R, Yekta A et al (2020) Global and regional prevalence of age-related cataract: a comprehensive systematic review and meta-analysis. Eye (lond) 34:1357\u20131370","journal-title":"Eye (lond)"},{"key":"10753_CR13","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1080\/02713683.2021.1978100","volume":"47","author":"J He","year":"2022","unstructured":"He J, Xie P, Ouyang J (2022) Circ_0122396 protects human lens epithelial cells from hydrogen peroxide-triggered injury by binding to miR-15a-5p to stimulate FGF1 expression. Curr Eye Res 47:246\u2013255","journal-title":"Curr Eye Res"},{"key":"10753_CR14","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1111\/febs.13598","volume":"283","author":"R Iurlaro","year":"2016","unstructured":"Iurlaro R, Mu\u00f1oz-Pinedo C (2016) Cell death induced by endoplasmic reticulum stress. Febs j 283:2640\u20132652","journal-title":"Febs j"},{"key":"10753_CR15","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","volume":"20","author":"LS Kristensen","year":"2019","unstructured":"Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J (2019) The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet 20:675\u2013691","journal-title":"Nat Rev Genet"},{"key":"10753_CR16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/bs.pmbts.2016.12.013","volume":"146","author":"S Kumar","year":"2017","unstructured":"Kumar S, Vijayan M, Bhatti JS, Reddy PH (2017) MicroRNAs as peripheral biomarkers in aging and age-related diseases. Prog Mol Biol Transl Sci 146:47\u201394","journal-title":"Prog Mol Biol Transl Sci"},{"key":"10753_CR17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/iovs.61.10.13","volume":"61","author":"P Li","year":"2020","unstructured":"Li P, Yu H, Zhang G et al (2020a) Identification and characterization of N6-methyladenosine circRNAs and methyltransferases in the lens epithelium cells from age-related cataract. Invest Ophthalmol vis Sci 61:13","journal-title":"Invest Ophthalmol vis Sci"},{"key":"10753_CR18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s12886-020-01489-8","volume":"20","author":"ZN Li","year":"2020","unstructured":"Li ZN, Ge MX, Yuan ZF (2020b) MicroRNA-182-5p protects human lens epithelial cells against oxidative stress-triggered apoptosis by inhibiting NOX4 and p38 MAPK signalling. BMC Ophthalmol 20:233","journal-title":"BMC Ophthalmol"},{"key":"10753_CR19","doi-asserted-by":"publisher","DOI":"10.1055\/a-1758-3451","author":"I Neuhann","year":"2022","unstructured":"Neuhann I, Neuhann L, Neuhann T (2022) Age-related cataract. Klin Monbl Augenheilkd. https:\/\/doi.org\/10.1055\/a-1758-3451","journal-title":"Klin Monbl Augenheilkd"},{"key":"10753_CR20","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2021.4892","author":"L Niu","year":"2021","unstructured":"Niu L, Liu X, Zhao J et al (2021) 5-Nitro-2-(3-phenylpropylamino) benzoic acid induces apoptosis of human lens epithelial cells via reactive oxygen species and endoplasmic reticulum stress through the mitochondrial apoptosis pathway. Int J Mol Med. https:\/\/doi.org\/10.3892\/ijmm.2021.4892","journal-title":"Int J Mol Med"},{"key":"10753_CR21","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.freeradbiomed.2014.04.010","volume":"72","author":"P Palsamy","year":"2014","unstructured":"Palsamy P, Bidasee KR, Ayaki M, Augusteyn RC, Chan JY, Shinohara T (2014) Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts. Free Radic Biol Med 72:134\u2013148","journal-title":"Free Radic Biol Med"},{"key":"10753_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.08.003","volume":"60","author":"P Periyasamy","year":"2017","unstructured":"Periyasamy P, Shinohara T (2017) Age-related cataracts: role of unfolded protein response, Ca(2+) mobilization, epigenetic DNA modifications, and loss of Nrf2\/Keap1 dependent cytoprotection. Prog Retin Eye Res 60:1\u201319","journal-title":"Prog Retin Eye Res"},{"key":"10753_CR23","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1016\/j.bbamcr.2013.06.028","volume":"1833","author":"R Sano","year":"2013","unstructured":"Sano R, Reed JC (2013) ER stress-triggered cell death mechanisms. Biochim Biophys Acta 1833:3460\u20133470","journal-title":"Biochim Biophys Acta"},{"key":"10753_CR24","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1053\/j.gastro.2020.06.088","volume":"159","author":"ST Stengel","year":"2020","unstructured":"Stengel ST, Fazio A, Lipinski S et al (2020) Activating transcription factor 6 mediates inflammatory signals in intestinal epithelial cells upon endoplasmic reticulum stress. Gastroenterology 159:1357\u201374.e10","journal-title":"Gastroenterology"},{"key":"10753_CR25","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.bbagen.2015.08.016","volume":"1860","author":"RJ Truscott","year":"2016","unstructured":"Truscott RJ, Friedrich MG (2016) The etiology of human age-related cataract: proteins don\u2019t last forever. Biochim Biophys Acta 1860:192\u2013198","journal-title":"Biochim Biophys Acta"},{"key":"10753_CR26","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108721","volume":"211","author":"Y Wang","year":"2021","unstructured":"Wang Y, Wu Z, Huang Y, Zhang Y (2021a) Hsa_circ_0004058 inhibits apoptosis of SRA01\/04 cells by promoting autophagy via miR-186\/ATG7 axis. Exp Eye Res 211:108721","journal-title":"Exp Eye Res"},{"key":"10753_CR27","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1080\/02713683.2021.1896742","volume":"46","author":"Y Wang","year":"2021","unstructured":"Wang Y, Zhang G, Li P et al (2021b) Profiling and integrated analysis of the ERCC6-regulated circRNA-miRNA-mRNA network in lens epithelial cells. Curr Eye Res 46:1341\u20131352","journal-title":"Curr Eye Res"},{"key":"10753_CR28","first-page":"497","volume":"65","author":"O Wawrzyniak","year":"2018","unstructured":"Wawrzyniak O, Zar\u0119bska \u017b, Rolle K, Gotz-Wi\u0119ckowska A (2018) Circular and long non-coding RNAs and their role in ophthalmologic diseases. Acta Biochim Pol 65:497\u2013508","journal-title":"Acta Biochim Pol"},{"key":"10753_CR29","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.2147\/DMSO.S286081","volume":"13","author":"CJ Weale","year":"2020","unstructured":"Weale CJ, Matshazi DM, Davids SFG et al (2020) Circulating miR-30a-5p and miR-182-5p in prediabetes and screen-detected diabetes mellitus. Diabetes Metab Syndr Obes 13:5037\u20135047","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10753_CR30","volume":"210","author":"TFL Wishart","year":"2021","unstructured":"Wishart TFL, Flokis M, Shu DY, Das SJ, Lovicu FJ (2021) Hallmarks of lens aging and cataractogenesis. Exp Eye Res 210:108709","journal-title":"Exp Eye Res"},{"key":"10753_CR31","first-page":"7074343","volume":"2021","author":"X Wu","year":"2021","unstructured":"Wu X, Wang W, Wu G, Peng C, Liu J (2021) miR-182-5p serves as an oncogene in lung adenocarcinoma through binding to STARD13. Comput Math Methods Med 2021:7074343","journal-title":"Comput Math Methods Med"},{"key":"10753_CR32","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1002\/cbin.11615","volume":"45","author":"X Xu","year":"2021","unstructured":"Xu X, Gao R, Li S et al (2021) Circular RNA circZNF292 regulates H(2) O(2) -triggered injury in human lens epithelial HLE-B3 cells depending on the regulation of the miR-222-3p\/E2F3 axis. Cell Biol Int 45:1757\u20131767","journal-title":"Cell Biol Int"},{"key":"10753_CR33","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.canlet.2020.04.021","volume":"488","author":"S Yan","year":"2020","unstructured":"Yan S, Wang H, Chen X et al (2020) MiR-182-5p inhibits colon cancer tumorigenesis, angiogenesis, and lymphangiogenesis by directly downregulating VEGF-C. Cancer Lett 488:18\u201326","journal-title":"Cancer Lett"},{"key":"10753_CR34","volume":"10","author":"J Yang","year":"2015","unstructured":"Yang J, Zhou S, Gu J, Wang Y, Guo M, Liu Y (2015) Differences in unfolded protein response pathway activation in the lenses of three types of cataracts. PLoS ONE 10:e0130705","journal-title":"PLoS ONE"},{"key":"10753_CR35","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/cr.2007.6","volume":"17","author":"H Yao","year":"2007","unstructured":"Yao H, Tang X, Shao X, Feng L, Wu N, Yao K (2007) Parthenolide protects human lens epithelial cells from oxidative stress-triggered apoptosis via inhibition of activation of caspase-3 and caspase-9. Cell Res 17:565\u2013571","journal-title":"Cell Res"},{"key":"10753_CR36","volume":"206","author":"M Zhang","year":"2021","unstructured":"Zhang M, Cheng K (2021) Long non-coding RNA KCNQ1OT1 promotes hydrogen peroxide-triggered lens epithelial cell apoptosis and oxidative stress by regulating miR-223-3p\/BCL2L2 axis. Exp Eye Res 206:108543","journal-title":"Exp Eye Res"},{"key":"10753_CR37","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3389\/fcell.2020.00850","volume":"8","author":"C Zhang","year":"2020","unstructured":"Zhang C, Hu J, Yu Y (2020) CircRNA Is a rising star in researches of ocular diseases. Front Cell Dev Biol 8:850","journal-title":"Front Cell Dev Biol"},{"key":"10753_CR38","first-page":"173","volume":"21","author":"S Zhou","year":"2020","unstructured":"Zhou S, Yang J, Wang M, Zheng D, Liu Y (2020) Endoplasmic reticulum stress regulates epithelial-mesenchymal transition in human lens epithelial cells. Mol Med Rep 21:173\u2013180","journal-title":"Mol Med Rep"},{"key":"10753_CR39","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1080\/02713683.2020.1855662","volume":"46","author":"B Zhou","year":"2021","unstructured":"Zhou B, Zhao G, Zhu Y et al (2021) Protective effects of nicotinamide riboside on H(2)O(2)-triggered oxidative damage in lens epithelial cells. Curr Eye Res 46:961\u2013970","journal-title":"Curr Eye Res"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-024-10753-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-024-10753-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-024-10753-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T04:45:26Z","timestamp":1742705126000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10528-024-10753-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,26]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10753"],"URL":"https:\/\/doi.org\/10.1007\/s10528-024-10753-1","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"type":"print","value":"0006-2928"},{"type":"electronic","value":"1573-4927"}],"subject":[],"published":{"date-parts":[[2024,3,26]]},"assertion":[{"value":"26 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The research related to human use has been complied with all the relevant national regulations, institutional policies and in accordance the tenets of the Helsinki Declaration, and has been approved by Ningbo Eye Hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}