{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T13:32:00Z","timestamp":1777037520747,"version":"3.51.4"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Knowledge Innovation Program of Wuhan Science and Technology Bureau","award":["2022020801010548"],"award-info":[{"award-number":["2022020801010548"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s10528-024-10757-x","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T17:02:23Z","timestamp":1709312543000},"page":"225-238","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["RBM15 Knockdown Impairs the Malignancy of Cervical Cancer by Mediating m6A Modification of Decorin"],"prefix":"10.1007","volume":"63","author":[{"given":"Huimin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Sha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"issue":"5","key":"10757_CR1","doi-asserted-by":"publisher","first-page":"266","DOI":"10.5732\/cjc.012.10301","volume":"32","author":"XL Bi","year":"2013","unstructured":"Bi XL, Yang W (2013) Biological functions of decorin in cancer. Chin J Cancer 32(5):266\u2013269. https:\/\/doi.org\/10.5732\/cjc.012.10301","journal-title":"Chin J Cancer"},{"key":"10757_CR2","doi-asserted-by":"publisher","first-page":"200238","DOI":"10.1016\/j.tvr.2022.200238","volume":"13","author":"CA Burmeister","year":"2022","unstructured":"Burmeister CA, Khan SF, Schafer G et al (2022) Cervical cancer therapies: current challenges and future perspectives. Tumour Virus Res 13:200238. https:\/\/doi.org\/10.1016\/j.tvr.2022.200238","journal-title":"Tumour Virus Res"},{"issue":"1","key":"10757_CR3","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/s41420-021-00703-w","volume":"7","author":"X Cai","year":"2021","unstructured":"Cai X, Chen Y, Man D et al (2021) RBM15 promotes hepatocellular carcinoma progression by regulating N6-methyladenosine modification of YES1 mRNA in an IGF2BP1-dependent manner. Cell Death Discov 7(1):315. https:\/\/doi.org\/10.1038\/s41420-021-00703-w","journal-title":"Cell Death Discov"},{"issue":"1","key":"10757_CR4","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3892\/br.2021.1436","volume":"15","author":"MLR Da Silva","year":"2021","unstructured":"Da Silva MLR, De Albuquerque B, Allyrio T et al (2021) The role of HPV-induced epigenetic changes in cervical carcinogenesis (review). Biomed Rep 15(1):60. https:\/\/doi.org\/10.3892\/br.2021.1436","journal-title":"Biomed Rep"},{"key":"10757_CR5","doi-asserted-by":"publisher","first-page":"801801","DOI":"10.3389\/fonc.2021.801801","volume":"11","author":"V Diehl","year":"2021","unstructured":"Diehl V, Huber LS, Trebicka J et al (2021) The role of Decorin and Biglycan Signaling in Tumorigenesis. Front Oncol 11:801801. https:\/\/doi.org\/10.3389\/fonc.2021.801801","journal-title":"Front Oncol"},{"key":"10757_CR6","doi-asserted-by":"publisher","unstructured":"Dong H, Zhang H, Mao X et al (2023) RBM15 promates the Proliferation, Migration and Invasion of Pancreatic Cancer Cell lines. Cancers (Basel) 15(4). https:\/\/doi.org\/10.3390\/cancers15041084","DOI":"10.3390\/cancers15041084"},{"key":"10757_CR7","doi-asserted-by":"publisher","first-page":"827956","DOI":"10.3389\/fonc.2022.827956","volume":"12","author":"W Huang","year":"2022","unstructured":"Huang W, Kong F, Li R et al (2022) Emerging roles of m(6)a RNA methylation regulators in Gynecological Cancer. Front Oncol 12:827956. https:\/\/doi.org\/10.3389\/fonc.2022.827956","journal-title":"Front Oncol"},{"issue":"14","key":"10757_CR8","doi-asserted-by":"publisher","first-page":"4776","DOI":"10.1158\/1078-0432.CCR-1190-03","volume":"10","author":"J Koninger","year":"2004","unstructured":"Koninger J, Giese NA, di Mola FF et al (2004) Overexpressed decorin in pancreatic cancer: potential tumor growth inhibition and attenuation of chemotherapeutic action. Clin Cancer Res 10(14):4776\u20134783. https:\/\/doi.org\/10.1158\/1078-0432.CCR-1190-03","journal-title":"Clin Cancer Res"},{"issue":"21","key":"10757_CR9","doi-asserted-by":"publisher","first-page":"4030","DOI":"10.1002\/cncr.33795","volume":"127","author":"S Lin","year":"2021","unstructured":"Lin S, Gao K, Gu S et al (2021) Worldwide trends in cervical cancer incidence and mortality, with predictions for the next 15 years. Cancer 127(21):4030\u20134039. https:\/\/doi.org\/10.1002\/cncr.33795","journal-title":"Cancer"},{"key":"10757_CR10","unstructured":"Ma X, Li Y, Wen J, Zhao Y (2020) m6A RNA methylation regulators contribute to malignant development and have a clinical prognostic effect on cervical cancer. Am J Transl Res 12(12): 8137\u20138146. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/33437387"},{"issue":"12","key":"10757_CR11","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1016\/j.molcel.2022.05.029","volume":"82","author":"S Murakami","year":"2022","unstructured":"Murakami S, Jaffrey SR (2022) Hidden codes in mRNA: control of gene expression by m(6)a. Mol Cell 82(12):2236\u20132251. https:\/\/doi.org\/10.1016\/j.molcel.2022.05.029","journal-title":"Mol Cell"},{"key":"10757_CR12","unstructured":"Nash MA, Loercher AE, Freedman RS (1999) In vitro growth inhibition of ovarian cancer cells by decorin: synergism of action between decorin and carboplatin. Cancer Res 59(24): 6192\u20136196. Retrieved from https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10626812"},{"issue":"7620","key":"10757_CR13","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/nature19342","volume":"537","author":"DP Patil","year":"2016","unstructured":"Patil DP, Chen CK, Pickering BF et al (2016) M(6)a RNA methylation promotes XIST-mediated transcriptional repression. Nature 537(7620):369\u2013373. https:\/\/doi.org\/10.1038\/nature19342","journal-title":"Nature"},{"issue":"6","key":"10757_CR14","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1038\/sj.onc.1208329","volume":"24","author":"CC Reed","year":"2005","unstructured":"Reed CC, Waterhouse A, Kirby S et al (2005) Decorin prevents metastatic spreading of breast cancer. Oncogene 24(6):1104\u20131110. https:\/\/doi.org\/10.1038\/sj.onc.1208329","journal-title":"Oncogene"},{"issue":"15","key":"10757_CR15","doi-asserted-by":"publisher","first-page":"7016","DOI":"10.1073\/pnas.92.15.7016","volume":"92","author":"M Santra","year":"1995","unstructured":"Santra M, Skorski T, Calabretta B et al (1995) De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells. Proc Natl Acad Sci U S A 92(15):7016\u20137020. https:\/\/doi.org\/10.1073\/pnas.92.15.7016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10757_CR16","doi-asserted-by":"publisher","first-page":"e197","DOI":"10.1016\/S2214-109X(22)00501-0","volume":"11","author":"D Singh","year":"2023","unstructured":"Singh D, Vignat J, Lorenzoni V et al (2023) Global estimates of incidence and mortality of cervical cancer in 2020: a baseline analysis of the WHO Global Cervical Cancer Elimination Initiative. Lancet Glob Health 11(2):e197\u2013e206. https:\/\/doi.org\/10.1016\/S2214-109X(22)00501-0","journal-title":"Lancet Glob Health"},{"issue":"9","key":"10757_CR17","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1002\/tox.23852","volume":"38","author":"Y Song","year":"2023","unstructured":"Song Y, Wu Q (2023) RBM15 m(6) a modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT\/mTOR signaling. Environ Toxicol 38(9):2155\u20132164. https:\/\/doi.org\/10.1002\/tox.23852","journal-title":"Environ Toxicol"},{"issue":"3","key":"10757_CR18","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL et al (2021) Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"10757_CR20","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s13046-021-01871-4","volume":"40","author":"X Wang","year":"2021","unstructured":"Wang X, Tian L, Li Y et al (2021) RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent. J Exp Clin Cancer Res 40(1):80. https:\/\/doi.org\/10.1186\/s13046-021-01871-4","journal-title":"J Exp Clin Cancer Res"},{"issue":"4","key":"10757_CR19","doi-asserted-by":"publisher","first-page":"9872","DOI":"10.1080\/21655979.2022.2062088","volume":"13","author":"H Wang","year":"2022","unstructured":"Wang H, Wang D, Wei Q et al (2022) Long non-coding RNAs PGM5-AS1 upregulates Decorin (DCN) to inhibit cervical cancer progression by sponging miR-4284. Bioengineered 13(4):9872\u20139884. https:\/\/doi.org\/10.1080\/21655979.2022.2062088","journal-title":"Bioengineered"},{"issue":"10","key":"10757_CR22","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1089\/cbr.2021.0226","volume":"37","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Mei Y, Hou M (2022) Knockdown RBM15 inhibits Colorectal Cancer Cell Proliferation and Metastasis Via N6-Methyladenosine (m6A) modification of MyD88 mRNA. Cancer Biother Radiopharm 37(10):976\u2013986. https:\/\/doi.org\/10.1089\/cbr.2021.0226","journal-title":"Cancer Biother Radiopharm"},{"issue":"1","key":"10757_CR21","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1186\/s12885-023-11163-z","volume":"23","author":"C Zhang","year":"2023","unstructured":"Zhang C, Gu L, Xiao J, Jin F (2023) Knockdown of RBM15 inhibits tumor progression and the JAK-STAT signaling pathway in cervical cancer. BMC Cancer 23(1):684. https:\/\/doi.org\/10.1186\/s12885-023-11163-z","journal-title":"BMC Cancer"},{"issue":"1","key":"10757_CR23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nrm.2016.132","volume":"18","author":"BS Zhao","year":"2017","unstructured":"Zhao BS, Roundtree IA, He C (2017) Post-transcriptional gene regulation by mRNA modifications. Nat Rev Mol Cell Biol 18(1):31\u201342. https:\/\/doi.org\/10.1038\/nrm.2016.132","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10757_CR24","doi-asserted-by":"publisher","first-page":"842833","DOI":"10.3389\/fmolb.2022.842833","volume":"9","author":"Z Zhao","year":"2022","unstructured":"Zhao Z, Ju Q, Ji J et al (2022) N6-Methyladenosine methylation Regulator RBM15 is a potential prognostic biomarker and promotes cell proliferation in pancreatic adenocarcinoma. Front Mol Biosci 9:842833. https:\/\/doi.org\/10.3389\/fmolb.2022.842833","journal-title":"Front Mol Biosci"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-024-10757-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-024-10757-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-024-10757-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T22:58:27Z","timestamp":1739833107000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10528-024-10757-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10757"],"URL":"https:\/\/doi.org\/10.1007\/s10528-024-10757-x","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,1]]},"assertion":[{"value":"12 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Ethics Committee of Wuhan Third Hospital (Tongren Hospital of Wuhan University, Wuhan, China) approved the experiment of clinical samples, and all patients signed a written informed consent. All clinical tissue samples is used in strict compliance with the ethical standards of the Declaration of Helsinki. All animal experiments were approved by Ethics Committee of Wuhan Third Hospital (Tongren Hospital of Wuhan University, Wuhan, China), and were carried out in accordance with National Research Council\u2019s Guide for the Care and Use of Laboratory Animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"All participants provided consent for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors have no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}