{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:37:06Z","timestamp":1792532226083,"version":"4.5.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s10528-024-10788-4","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T08:02:40Z","timestamp":1712822560000},"page":"1647-1659","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Overexpression of PIK3CG in Cancer Cells Promotes Lung Cancer Cell Migration and Metastasis Through Enhanced MMPs Expression and Neutrophil Recruitment and Activation"],"prefix":"10.1007","volume":"63","author":[{"given":"Jinpeng","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenshan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghui","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyue","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengmei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"issue":"3","key":"10788_CR1","doi-asserted-by":"publisher","first-page":"C679","DOI":"10.1152\/ajpcell.00351.2009","volume":"298","author":"AE Awad","year":"2010","unstructured":"Awad AE, Kandalam V, Chakrabarti S, Wang X, Penninger JM, Davidge ST et al (2010) Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner. Am J Physiol Cell Physiol 298(3):C679\u2013C692. https:\/\/doi.org\/10.1152\/ajpcell.00351.2009","journal-title":"Am J Physiol Cell Physiol"},{"issue":"7490","key":"10788_CR2","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nature13111","volume":"507","author":"T Bald","year":"2014","unstructured":"Bald T, Quast T, Landsberg J, Rogava M, Glodde N, Lopez-Ramos D et al (2014) Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma. Nature 507(7490):109\u2013113. https:\/\/doi.org\/10.1038\/nature13111","journal-title":"Nature"},{"issue":"3","key":"10788_CR3","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nm.4045","volume":"22","author":"H Beltran","year":"2016","unstructured":"Beltran H, Prandi D, Mosquera JM, Benelli M, Puca L, Cyrta J et al (2016) Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer. Nat Med 22(3):298\u2013305. https:\/\/doi.org\/10.1038\/nm.4045","journal-title":"Nat Med"},{"issue":"3","key":"10788_CR4","doi-asserted-by":"publisher","first-page":"a000752","DOI":"10.1101\/mcs.a000752","volume":"2","author":"GS Bova","year":"2016","unstructured":"Bova GS, Kallio HM, Annala M, Kivinummi K, Hognas G, Hayrynen S et al (2016) Integrated clinical, whole-genome, and transcriptome analysis of multisampled lethal metastatic prostate cancer. Cold Spring Harb Mol Case Stud 2(3):a000752. https:\/\/doi.org\/10.1101\/mcs.a000752","journal-title":"Cold Spring Harb Mol Case Stud"},{"key":"10788_CR5","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.2147\/CMAR.S250171","volume":"12","author":"J Chang","year":"2020","unstructured":"Chang J, Hong L, Liu Y, Pan Y, Yang H, Ye W et al (2020) Targeting PIK3CG in combination with paclitaxel as a potential therapeutic regimen in claudin-low breast cancer. Cancer Manag Res 12:2641\u20132651. https:\/\/doi.org\/10.2147\/CMAR.S250171","journal-title":"Cancer Manag Res"},{"issue":"2","key":"10788_CR6","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.bbrc.2015.06.168","volume":"464","author":"S Chen","year":"2015","unstructured":"Chen S, Li F, Chai H, Tao X, Wang H, Ji A (2015) miR-502 inhibits cell proliferation and tumor growth in hepatocellular carcinoma through suppressing phosphoinositide 3-kinase catalytic subunit gamma. Biochem Biophys Res Commun 464(2):500\u2013505. https:\/\/doi.org\/10.1016\/j.bbrc.2015.06.168","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"10788_CR7","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1016\/j.ajpath.2020.07.013","volume":"190","author":"WC Chung","year":"2020","unstructured":"Chung WC, Zhou X, Atfi A, Xu K (2020) PIK3CG is a potential therapeutic target in androgen receptor-indifferent metastatic prostate cancer. Am J Pathol 190(11):2194\u20132202. https:\/\/doi.org\/10.1016\/j.ajpath.2020.07.013","journal-title":"Am J Pathol"},{"issue":"4","key":"10788_CR8","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/s41568-020-00329-7","volume":"21","author":"TR Cox","year":"2021","unstructured":"Cox TR (2021) The matrix in cancer. Nat Rev Cancer 21(4):217\u2013238. https:\/\/doi.org\/10.1038\/s41568-020-00329-7","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"10788_CR9","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1093\/neuros\/nyaa471","volume":"88","author":"A Dono","year":"2021","unstructured":"Dono A, Takayasu T, Yan Y, Bundrant BE, Arevalo O, Lopez-Garcia CA et al (2021) Differences in genomic alterations between brain metastases and primary tumors. Neurosurgery 88(3):592\u2013602. https:\/\/doi.org\/10.1093\/neuros\/nyaa471","journal-title":"Neurosurgery"},{"key":"10788_CR10","doi-asserted-by":"publisher","first-page":"451","DOI":"10.2147\/jhc.S303588","volume":"8","author":"X Guan","year":"2021","unstructured":"Guan X, Lu Y, Zhu H, Yu S, Zhao W, Chi X et al (2021) The crosstalk between cancer cells and neutrophils enhances hepatocellular carcinoma metastasis via neutrophil extracellular traps-associated Cathepsin G component: a potential therapeutic target. J Hepatocell Carcinoma 8:451\u2013465. https:\/\/doi.org\/10.2147\/jhc.S303588","journal-title":"J Hepatocell Carcinoma"},{"issue":"7205","key":"10788_CR11","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1038\/nature07091","volume":"454","author":"S Jia","year":"2008","unstructured":"Jia S, Liu Z, Zhang S, Liu P, Zhang L, Lee SH et al (2008) Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature 454(7205):776\u2013779. https:\/\/doi.org\/10.1038\/nature07091","journal-title":"Nature"},{"issue":"1","key":"10788_CR12","doi-asserted-by":"publisher","first-page":"e13122","DOI":"10.15252\/emmm.202013122","volume":"13","author":"J Ko","year":"2021","unstructured":"Ko J, Winslow MM, Sage J (2021) Mechanisms of small cell lung cancer metastasis. EMBO Mol Med 13(1):e13122. https:\/\/doi.org\/10.15252\/emmm.202013122","journal-title":"EMBO Mol Med"},{"issue":"2","key":"10788_CR13","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.ccell.2016.06.021","volume":"30","author":"Y Liu","year":"2016","unstructured":"Liu Y, Gu Y, Han Y, Zhang Q, Jiang Z, Zhang X et al (2016) Tumor exosomal RNAs promote lung pre-metastatic niche formation by activating alveolar epithelial TLR3 to recruit neutrophils. Cancer Cell 30(2):243\u2013256. https:\/\/doi.org\/10.1016\/j.ccell.2016.06.021","journal-title":"Cancer Cell"},{"issue":"11","key":"10788_CR14","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/nri.2016.93","volume":"16","author":"CL Lucas","year":"2016","unstructured":"Lucas CL, Chandra A, Nejentsev S, Condliffe AM, Okkenhaug K (2016) PI3K\u03b4 and primary immunodeficiencies. Nat Rev Immunol 16(11):702\u2013714. https:\/\/doi.org\/10.1038\/nri.2016.93","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"10788_CR15","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/s1043-4682(05)80007-8","volume":"6","author":"CA Owen","year":"1995","unstructured":"Owen CA, Campbell EJ (1995) Neutrophil proteinases and matrix degradation. The cell biology of pericellular proteolysis. Semin Cell Biol 6(6):367\u2013376. https:\/\/doi.org\/10.1016\/s1043-4682(05)80007-8","journal-title":"Semin Cell Biol"},{"issue":"1","key":"10788_CR16","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1182\/blood-2005-01-0023","volume":"106","author":"KD Puri","year":"2005","unstructured":"Puri KD, Doggett TA, Huang CY, Douangpanya J, Hayflick JS, Turner M et al (2005) The role of endothelial PI3Kgamma activity in neutrophil trafficking. Blood 106(1):150\u2013157. https:\/\/doi.org\/10.1182\/blood-2005-01-0023","journal-title":"Blood"},{"issue":"6","key":"10788_CR17","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1164\/rccm.201902-0294OC","volume":"201","author":"J Qian","year":"2020","unstructured":"Qian J, Zhao S, Zou Y, Rahman SMJ, Senosain MF, Stricker T et al (2020) Genomic underpinnings of tumor behavior in in situ and early lung adenocarcinoma. Am J Respir Crit Care Med 201(6):697\u2013706. https:\/\/doi.org\/10.1164\/rccm.201902-0294OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"5670","key":"10788_CR18","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1126\/science.1096502","volume":"304","author":"Y Samuels","year":"2004","unstructured":"Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S et al (2004) High frequency of mutations of the PIK3CA gene in human cancers. Science 304(5670):554. https:\/\/doi.org\/10.1126\/science.1096502","journal-title":"Science"},{"issue":"1","key":"10788_CR19","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s13000-023-01349-1","volume":"18","author":"F Shen","year":"2023","unstructured":"Shen F, Guo W, Song X, Wang B (2023) Molecular profiling and prognostic biomarkers in chinese non-small cell lung cancer cohort. Diagn Pathol 18(1):71. https:\/\/doi.org\/10.1186\/s13000-023-01349-1","journal-title":"Diagn Pathol"},{"issue":"3","key":"10788_CR20","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"issue":"7745","key":"10788_CR21","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/s41586-019-0915-y","volume":"566","author":"BM Szczerba","year":"2019","unstructured":"Szczerba BM, Castro-Giner F, Vetter M, Krol I, Gkountela S, Landin J et al (2019) Neutrophils escort circulating tumour cells to enable cell cycle progression. Nature 566(7745):553\u2013557. https:\/\/doi.org\/10.1038\/s41586-019-0915-y","journal-title":"Nature"},{"issue":"29","key":"10788_CR22","doi-asserted-by":"publisher","first-page":"14724","DOI":"10.1073\/pnas.1813012116","volume":"116","author":"C Torres","year":"2019","unstructured":"Torres C, Mancinelli G, Cordoba-Chacon J, Viswakarma N, Castellanos K, Grimaldo S et al (2019) p110gamma deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity. Proc Natl Acad Sci USA 116(29):14724\u201314733. https:\/\/doi.org\/10.1073\/pnas.1813012116","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10788_CR23","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/s41467-020-20733-9","volume":"12","author":"A Tyagi","year":"2021","unstructured":"Tyagi A, Sharma S, Wu K, Wu SY, Xing F, Liu Y et al (2021) Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung. Nat Commun 12(1):474. https:\/\/doi.org\/10.1038\/s41467-020-20733-9","journal-title":"Nat Commun"},{"issue":"6","key":"10788_CR25","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1534\/g3.120.401128","volume":"10","author":"L van der Weyden","year":"2020","unstructured":"van der Weyden L, Swiatkowska A, Iyer V, Speak AO, Adams DJ (2020) A genome-wide screen in mice to identify cell-extrinsic regulators of pulmonary metastatic colonisation. G3 (bethesda). 10(6):1869\u20131877. https:\/\/doi.org\/10.1534\/g3.120.401128","journal-title":"G3 (bethesda)."},{"issue":"1","key":"10788_CR24","doi-asserted-by":"publisher","first-page":"111","DOI":"10.2478\/acph-2019-0004","volume":"69","author":"X Wang","year":"2019","unstructured":"Wang X, Huang S, Xin X, Ren Y, Weng G, Wang P (2019) The antitumor activity of umbelliferone in human renal cell carcinoma via regulation of the p110gamma catalytic subunit of PI3Kgamma. Acta Pharm 69(1):111\u2013119. https:\/\/doi.org\/10.2478\/acph-2019-0004","journal-title":"Acta Pharm"},{"issue":"63","key":"10788_CR26","doi-asserted-by":"publisher","first-page":"106672","DOI":"10.18632\/oncotarget.22508","volume":"8","author":"SM Woo","year":"2017","unstructured":"Woo SM, Min KJ, Seo SU, Kim S, Park JW, Song DK et al (2017) Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin. Oncotarget 8(63):106672\u2013106684. https:\/\/doi.org\/10.18632\/oncotarget.22508","journal-title":"Oncotarget"},{"issue":"1","key":"10788_CR27","doi-asserted-by":"publisher","first-page":"7417","DOI":"10.1080\/21655979.2021.1974779","volume":"12","author":"W Wu","year":"2021","unstructured":"Wu W, Jia L, Zhang Y, Zhao J, Dong Y, Qiang Y (2021) Exploration of the prognostic signature reflecting tumor microenvironment of lung adenocarcinoma based on immunologically relevant genes. Bioengineered 12(1):7417\u20137431. https:\/\/doi.org\/10.1080\/21655979.2021.1974779","journal-title":"Bioengineered"},{"issue":"3","key":"10788_CR28","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.ccell.2020.12.012","volume":"39","author":"Y Xiao","year":"2021","unstructured":"Xiao Y, Cong M, Li J, He D, Wu Q, Tian P et al (2021) Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. Cancer Cell 39(3):423\u201337.e7. https:\/\/doi.org\/10.1016\/j.ccell.2020.12.012","journal-title":"Cancer Cell"},{"issue":"1","key":"10788_CR29","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1186\/s12885-022-09597-y","volume":"22","author":"H Yang","year":"2022","unstructured":"Yang H, Wen L, Pan Y, Shan C, Hong W, Wang H et al (2022) Gene alternation of cerebrospinal fluid in patients with leptomeningeal metastases of lung adenocarcinoma using next-generation sequencing. BMC Cancer 22(1):580. https:\/\/doi.org\/10.1186\/s12885-022-09597-y","journal-title":"BMC Cancer"},{"issue":"1","key":"10788_CR30","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1186\/s12967-021-02985-1","volume":"19","author":"L Yin","year":"2021","unstructured":"Yin L, Liu X, Shao X, Feng T, Xu J, Wang Q et al (2021) The role of exosomes in lung cancer metastasis and clinical applications: an updated review. J Transl Med 19(1):312. https:\/\/doi.org\/10.1186\/s12967-021-02985-1","journal-title":"J Transl Med"},{"issue":"1","key":"10788_CR31","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1080\/21655979.2021.2020549","volume":"13","author":"C Zeng","year":"2022","unstructured":"Zeng C, Yuan G, Hu Y, Wang D, Shi X, Zhu D et al (2022) Repressing phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma by microRNA-142-3p restrains the progression of hepatocellular carcinoma. Bioengineered 13(1):1491\u20131506. https:\/\/doi.org\/10.1080\/21655979.2021.2020549","journal-title":"Bioengineered"},{"issue":"10","key":"10788_CR32","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1158\/0008-5472.CAN-14-3303","volume":"75","author":"S Zhang","year":"2015","unstructured":"Zhang S, Chung WC, Wu G, Egan SE, Miele L, Xu K (2015) Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction. Cancer Res 75(10):1936\u20131943. https:\/\/doi.org\/10.1158\/0008-5472.CAN-14-3303","journal-title":"Cancer Res"},{"issue":"1","key":"10788_CR33","doi-asserted-by":"publisher","first-page":"11255","DOI":"10.1038\/s41598-018-29308-7","volume":"8","author":"HW Zhang","year":"2018","unstructured":"Zhang HW, Hu JJ, Fu RQ, Liu X, Zhang YH, Li J et al (2018) Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kgamma mediated PI3K\/AKT\/mTOR\/p70S6K\/ULK signaling pathway in human breast cancer cells. Sci Rep 8(1):11255. https:\/\/doi.org\/10.1038\/s41598-018-29308-7","journal-title":"Sci Rep"},{"key":"10788_CR34","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.canlet.2018.10.035","volume":"442","author":"P Zhang","year":"2019","unstructured":"Zhang P, Kang B, Xie G, Li S, Gu Y, Shen Y et al (2019) Genomic sequencing and editing revealed the GRM8 signaling pathway as potential therapeutic targets of squamous cell lung cancer. Cancer Lett 442:53\u201367. https:\/\/doi.org\/10.1016\/j.canlet.2018.10.035","journal-title":"Cancer Lett"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-024-10788-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-024-10788-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-024-10788-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T04:40:03Z","timestamp":1742704803000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10528-024-10788-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,11]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10788"],"URL":"https:\/\/doi.org\/10.1007\/s10528-024-10788-4","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,11]]},"assertion":[{"value":"3 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests exist.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}