{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:55:47Z","timestamp":1789077347462,"version":"build-2803163510"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T00:00:00Z","timestamp":1732406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T00:00:00Z","timestamp":1732406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10528-024-10963-7","type":"journal-article","created":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T02:43:58Z","timestamp":1732416238000},"page":"5124-5141","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of circANKLE2 & circL3MBTL4 -RNAs Expression in Fertile and Infertile Men"],"prefix":"10.1007","volume":"63","author":[{"given":"Randa","family":"El-Gamal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Zalata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shireen A.","family":"Mazroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Comhaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Gamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3031-3599","authenticated-orcid":false,"given":"Olfat G.","family":"Shaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha M.","family":"Hazem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,24]]},"reference":[{"key":"10963_CR1","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.cell.2012.04.043","volume":"150","author":"C Asencio","year":"2012","unstructured":"Asencio C, Davidson IF, Santarella-Mellwig R, Ly-Hartig TB, Mall M, Wallenfang MR et al (2012) Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis. Cell 150:122\u2013135. https:\/\/doi.org\/10.1016\/j.cell.2012.04.043","journal-title":"Cell"},{"key":"10963_CR2","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1006\/dbio.1998.9155","volume":"207","author":"WM Baarends","year":"1999","unstructured":"Baarends WM, Hoogerbrugge JW, Roest HP, Ooms M, Vreeburg J, Hoeijmakers JH et al (1999) Histone ubiquitination and chromatin remodeling in mouse spermatogenesis. Dev Biol 207:322\u2013333","journal-title":"Dev Biol"},{"key":"10963_CR3","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1083\/jcb.93.2.298","volume":"93","author":"R Balhorn","year":"1982","unstructured":"Balhorn R (1982) A model for the structure of chromatin in mammalian sperm. J Cell Biol 93:298\u2013305","journal-title":"J Cell Biol"},{"key":"10963_CR4","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1242\/dev.128074","volume":"143","author":"SP Barrett","year":"2016","unstructured":"Barrett SP, Salzman J (2016) Circular RNAs: analysis, expression and potential functions. Development 143:1838\u20131847","journal-title":"Development"},{"key":"10963_CR5","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1530\/REP-12-0326","volume":"144","author":"J Blanco-Rodriguez","year":"2012","unstructured":"Blanco-Rodriguez J (2012) Programmed phosphorylation of histone H2AX precedes a phase of DNA double-strand break-independent synapsis in mouse meiosis. Reproduction 144:699\u2013712","journal-title":"Reproduction"},{"issue":"12","key":"10963_CR6","first-page":"1368","volume":"11","author":"F Boitrelle","year":"2021","unstructured":"Boitrelle F, Shah R, Saleh R, Henkel R, Kandil H, Chung E, Vogiatzi P, Zini A, Arafa M, Agarwal A (2021) The sixth edition of the WHO manual for human semen analysis: a critical review and SWOT analysis. Life (Basel Switzerland) 11(12):1368","journal-title":"Life (Basel Switzerland)"},{"key":"10963_CR7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.semcdb.2009.09.010","volume":"21","author":"R Bonasio","year":"2010","unstructured":"Bonasio R, Lecona E, Reinberg D (2010) MBT domain proteins in development and disease. Semin Cell Dev Biol 21:221\u2013230","journal-title":"Semin Cell Dev Biol"},{"key":"10963_CR8","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.18632\/aging.101565","volume":"10","author":"H Cai","year":"2018","unstructured":"Cai H, Li Y, Li H, Niringiyumukiza JD, Zhang M, Chen L et al (2018) Identification and characterization of human ovary-derived circular RNAs and their potential roles in ovarian aging. Aging 10:2511\u20132534. https:\/\/doi.org\/10.18632\/aging.101565","journal-title":"Aging"},{"key":"10963_CR9","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1126\/science.1076997","volume":"298","author":"R Cao","year":"2002","unstructured":"Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y (2002) Role of histone H3 lysine 27 methylation in polycomb-group silencing. Science 298:1039\u20131043","journal-title":"Science"},{"key":"10963_CR10","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1002\/wrna.1294","volume":"6","author":"I Chen","year":"2015","unstructured":"Chen I, Chen CY, Chuang TJ (2015) Biogenesis, identification, and function of exonic circular RNAs. Wiley Interdiscip Rev RNA 6:563\u2013579. https:\/\/doi.org\/10.1002\/wrna.1294","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"10963_CR11","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1136\/jmedgenet","volume":"53","author":"Y Chen","year":"2016","unstructured":"Chen Y, Li C, Tan C, Liu X (2016) Circular RNAs: a new frontier in the study of human diseases. J Med Genet 53:359\u2013365. https:\/\/doi.org\/10.1136\/jmedgenet","journal-title":"J Med Genet"},{"key":"10963_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2019.00435","volume":"10","author":"T Chioccarelli","year":"2019","unstructured":"Chioccarelli T, Manfrevola F, Ferraro B, Sellitto C, Cobellis G, Migliaccio M, Fasano S, Pierantoni R, Chianese R (2019) Expression patterns of circular RNAs in high quality and poor quality human spermatozoa. Front Endocrinol 10:1\u201314","journal-title":"Front Endocrinol"},{"key":"10963_CR13","doi-asserted-by":"publisher","first-page":"17053","DOI":"10.1038\/nplants.2017.53","volume":"3","author":"VM Conn","year":"2017","unstructured":"Conn VM, Hugouvieux V, Nayak A, Conos SA, Capovilla G, Cildir G et al (2017) A circRNA from SEPALLATA3 regulates splicing of its cognate mRNA through R-loop formation. Nat Plants 3:17053. https:\/\/doi.org\/10.1038\/nplants.2017.53","journal-title":"Nat Plants"},{"key":"10963_CR14","first-page":"527","volume":"89","author":"M Cort\u00e9s-L\u00f2pez","year":"2016","unstructured":"Cort\u00e9s-L\u00f2pez M, Miura P (2016) Emerging functions of circular RNAs. Yale J Biol Med 89:527\u2013537","journal-title":"Yale J Biol Med"},{"key":"10963_CR15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0092-8674(02)00975-3","volume":"111","author":"B Czermin","year":"2002","unstructured":"Czermin B, Melfi R, McCabe D, Seitz V, Imhof A, Pirrotta V (2002) Drosophila enhancer of zeste\/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal polycomb sites. Cell 111:185\u2013196","journal-title":"Cell"},{"key":"10963_CR16","doi-asserted-by":"publisher","first-page":"39080","DOI":"10.1038\/srep39080","volume":"6","author":"WW Dong","year":"2016","unstructured":"Dong WW, Li HM, Qing XR, Huang DH, Li HG (2016) Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Sci Rep 6:39080. https:\/\/doi.org\/10.1038\/srep39080","journal-title":"Sci Rep"},{"key":"10963_CR17","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1530\/REP-17-0358","volume":"154","author":"RA Elkhatib","year":"2017","unstructured":"Elkhatib RA, Paci M, Boissier R, Longepied G, Auguste Y, Achard V et al (2017) LEM-domain proteins are lost during human spermiogenesis but BAF and BAF-L persist. Reproduction 154:387\u2013401. https:\/\/doi.org\/10.1530\/REP-17-0358","journal-title":"Reproduction"},{"issue":"17","key":"10963_CR18","first-page":"681","volume":"116","author":"A Endtz","year":"1972","unstructured":"Endtz A (1972) A direct staining method for moist urinary sediment and moist human sperm. Ned Tijdschr Geneeskd 116(17):681\u2013685","journal-title":"Ned Tijdschr Geneeskd"},{"key":"10963_CR19","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000166638","volume":"5","author":"R Garcia-Cruz","year":"2009","unstructured":"Garcia-Cruz R, Roig I, Caldes MG (2009) Maternal origin of the human aneuploidies. Are homolog synapsis and recombination to blame? Notes (learned) from the underbelly. Genome Dyn 5:128\u2013136","journal-title":"Genome Dyn"},{"key":"10963_CR20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0925-4773(93)90052-Y","volume":"41","author":"E Gateff","year":"1993","unstructured":"Gateff E, L\u00f6ffler T, Wismar J (1993) A temperature-sensitive brain tumor suppressor mutation of Drosophila melanogaster: developmental studies and molecular localization of the gene. Mech Dev 41:15\u201331","journal-title":"Mech Dev"},{"key":"10963_CR21","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1095\/biolreprod.107.062265","volume":"77","author":"M Godmann","year":"2007","unstructured":"Godmann M, Auger V, Ferraroni-Aguiar V, Di Sauro A, Sette C, Behr R et al (2007) Dynamic regulation of histone H3 methylation at lysine 4 in mammalian spermatogenesis. Biol Reprod 77:754\u2013764","journal-title":"Biol Reprod"},{"key":"10963_CR22","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/sj.emboj.7601470","volume":"26","author":"M Gorjanacz","year":"2007","unstructured":"Gorjanacz M, Klerkx EP, Galy V, Santarella R, Lopez-Iglesias C, Askjaer P et al (2007) Caenorhabditis elegans BAF-1 and its kinase VRK-1 participate directly in post-mitotic nuclear envelope assembly. EMBO J 26:132\u2013143. https:\/\/doi.org\/10.1038\/sj.emboj.7601470","journal-title":"EMBO J"},{"key":"10963_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.04.034","author":"LT Gou","year":"2017","unstructured":"Gou LT, Kang JY, Dai P, Wang X, Li F, Zhao S et al (2017) Ubiquitination-deficient mutations in human piwi cause male infertility by impairing histone-to-protamine exchange during spermiogenesis. Cell. https:\/\/doi.org\/10.1016\/j.cell.2017.04.034","journal-title":"Cell"},{"key":"10963_CR24","first-page":"1","volume":"8","author":"S Haque","year":"2017","unstructured":"Haque S, Harries LW (2017) Circular RNAs (CircRNAs) in health and disease. Genes (Basel) 8:1\u201317","journal-title":"Genes (Basel)"},{"key":"10963_CR25","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1242\/jcs.033597","volume":"121","author":"T Haraguchi","year":"2008","unstructured":"Haraguchi T, Kojidani T, Koujin T, Shimi T, Osakada H, Mori C et al (2008) Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly. J Cell Sci 121:2540\u20132554. https:\/\/doi.org\/10.1242\/jcs.033597","journal-title":"J Cell Sci"},{"key":"10963_CR26","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1078\/0171-9335-00123","volume":"79","author":"M Hazzouri","year":"2000","unstructured":"Hazzouri M, Pivot-Pajot C, Faure AK, Usson Y, Pelletier R, Sele B et al (2000) Regulated hyperacetylation of core histones during mouse spermatogenesis: involvement of histone deacetylases. Eur J Cell Biol 79:950\u2013960","journal-title":"Eur J Cell Biol"},{"issue":"3","key":"10963_CR27","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/j.1939-4640.1995.tb00525.x","volume":"16","author":"R Henkel","year":"1995","unstructured":"Henkel R, M\u00fcller C, Miska W, Schill WB, Kleinstein J, Gips H (1995) Acrosin activity of human spermatozoa by means of a simple gelatinolytic technique: a method useful for IVF. J Androl 16(3):272\u2013277","journal-title":"J Androl"},{"key":"10963_CR28","first-page":"1","volume":"636","author":"RA Hess","year":"2008","unstructured":"Hess RA, de Franca LR (2008) Spermatogenesis and cycle of the seminiferous epithelium. Adv Exp Med Biol 636:1\u201315","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"10963_CR29","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0015-0282(16)60197-8","volume":"50","author":"A Hinting","year":"1988","unstructured":"Hinting A, Comhaire F, Schoonjans F (1988) Capacity of objectively assessed sperm motility characteristics in differentiating between semen of fertile and subfertile men. Fertil Steril 50(4):635\u2013639","journal-title":"Fertil Steril"},{"key":"10963_CR30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jbiotec.2016.09.011","volume":"238","author":"FR Kulcheski","year":"2016","unstructured":"Kulcheski FR, Christoff AP, Margis R (2016) Circular RNAs are miRNA sponges and can be used as a new class of biomarker. J Biotechnol 238:42\u201351","journal-title":"J Biotechnol"},{"key":"10963_CR31","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1101\/gad.1035902","volume":"16","author":"A Kuzmichev","year":"2002","unstructured":"Kuzmichev A, Erdjument-Bromage H, Tempst P, Reinberg D (2002) Histone methyltransferase activity associated with a human multiprotein complex containing the enhancer of zeste protein. Genes Dev 16:2893\u20132905","journal-title":"Genes Dev"},{"issue":"7","key":"10963_CR32","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.3390\/biom13071046","volume":"13","author":"M-A Kyrgiafini","year":"2023","unstructured":"Kyrgiafini M-A, Mamuris Z (2023) Circular RNAs and their role in male infertility: a systematic review. Biomolecules 13(7):1046","journal-title":"Biomolecules"},{"key":"10963_CR33","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/nsmb.2959","volume":"22","author":"Z Li","year":"2015","unstructured":"Li Z, Huang C, Bao C, Chen L, Lin M, Wang X et al (2015) Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol 22:256\u2013264. https:\/\/doi.org\/10.1038\/nsmb.2959","journal-title":"Nat Struct Mol Biol"},{"issue":"6","key":"10963_CR34","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.devcel.2019.10.009","volume":"51","author":"N Link","year":"2019","unstructured":"Link N, Chung H, Jolly A et al (2019) Mutations in ANKLE2, a ZIKA virus target, disrupt an asymmetric cell division pathway in Drosophila neuroblasts to cause microcephaly. Dev Cell 51(6):713-729.e6","journal-title":"Dev Cell"},{"key":"10963_CR35","doi-asserted-by":"publisher","first-page":"4598","DOI":"10.1073\/pnas.0730821100","volume":"100","author":"J Liu","year":"2003","unstructured":"Liu J, Lee KK, Segura-Totten M, Neufeld E, Wilson KL, Gruenbaum Y (2003) MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans. Proc Natl Acad Sci USA 100:4598\u20134603. https:\/\/doi.org\/10.1073\/pnas.0730821100","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10963_CR36","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method. Methods 25(4):402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"10963_CR37","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.devcel.2010.01.010","volume":"18","author":"LY Lu","year":"2010","unstructured":"Lu LY, Wu J, Ye L, Gavrilina GB, Saunders TL, Yu X (2010) RNF8- dependent histone modifications regulate nucleosome removal during spermatogenesis. Dev Cell 18:371\u2013384","journal-title":"Dev Cell"},{"key":"10963_CR38","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/85830","volume":"27","author":"SK Mahadevaiah","year":"2001","unstructured":"Mahadevaiah SK, Turner JM, Baudat F, Rogakou EP, de Boer P, Blanco-Rodriguez J et al (2001) Recombinational DNA double-strand breaks in mice precede synapsis. Nat Genet 27:271\u2013276","journal-title":"Nat Genet"},{"key":"10963_CR39","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.tcb.2007.02.004","volume":"17","author":"A Margalit","year":"2007","unstructured":"Margalit A, Brachner A, Gotzmann J, Foisner R, Gruenbaum Y (2007) Barrier-toautointegration factor\u2013a BAFfling little protein. Trends Cell Biol 17:202\u2013208","journal-title":"Trends Cell Biol"},{"key":"10963_CR40","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature11928","volume":"495","author":"S Memczak","year":"2013","unstructured":"Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A et al (2013) Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 495:333\u2013338. https:\/\/doi.org\/10.1038\/nature11928","journal-title":"Nature"},{"issue":"11","key":"10963_CR41","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1038\/s41418-019-0283-z","volume":"26","author":"C Meng","year":"2019","unstructured":"Meng C, Liao J, Zhao D, Huang H, Qin J, Lee T, Chen D, Chan W, Xia Y (2019) L3MBTL2 regulates chromatin remodeling during spermatogenesis. Cell Death Differ 26(11):2194\u20132207. https:\/\/doi.org\/10.1038\/s41418-019-0283-z","journal-title":"Cell Death Differ"},{"key":"10963_CR42","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1101\/gad.220095.113","volume":"27","author":"E Montellier","year":"2013","unstructured":"Montellier E, Boussouar F, Rousseaux S, Zhang K, Buchou T, Fenaille F et al (2013) Chromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B. Genes Dev 27:1680\u20131692","journal-title":"Genes Dev"},{"key":"10963_CR43","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/nature08397","volume":"461","author":"J Moriniere","year":"2009","unstructured":"Moriniere J, Rousseaux S, Steuerwald U, Soler-Lopez M, Curtet S, Vitte AL et al (2009) Cooperative binding of two acetylation marks on a histone tail by a single bromodomain. Nature 461:664\u2013668","journal-title":"Nature"},{"key":"10963_CR44","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0092-8674(02)00976-5","volume":"111","author":"J M\u00fcller","year":"2002","unstructured":"M\u00fcller J, Hart CM, Francis NJ, Vargas ML, Sengupta A, Wild B, Miller EL, O\u2019Connor MB, Kingston RE, Simon JA (2002) Histone methyltransferase activity of a drosophila polycomb group repressor complex. Cell 111:197\u2013208","journal-title":"Cell"},{"key":"10963_CR45","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1126\/science.1069861","volume":"296","author":"H Ogawa","year":"2002","unstructured":"Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y (2002) A complex with chromatin modifiers that occupies E2F- and Mycresponsive genes in G0 cells. Science 296:1132\u20131136","journal-title":"Science"},{"key":"10963_CR46","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/S0959-437X(03)00108-4","volume":"13","author":"AP Otte","year":"2003","unstructured":"Otte AP, Kwaks THJ (2003) Gene repression by polycomb group protein complexes: a distinct complex for every occasion? Curr Opin Genet Dev 13:448\u2013454","journal-title":"Curr Opin Genet Dev"},{"key":"10963_CR47","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1038\/sj.emboj.7600402","volume":"23","author":"D Pasini","year":"2004","unstructured":"Pasini D, Bracken AP, Jensen MR, Denchi EL, Helin K (2004) Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J 23:4061\u20134071","journal-title":"EMBO J"},{"key":"10963_CR48","unstructured":"Primer- BLAST (2019) https:\/\/www.ncbi.nlm.nih.gov\/tools\/primer-blast\/"},{"key":"10963_CR49","unstructured":"Primer3 web (2019) http:\/\/primer3.ut.ee"},{"key":"10963_CR50","first-page":"7016","volume":"14","author":"X Ren","year":"2017","unstructured":"Ren X, Du Y, You L, Zhao Y (2017) Potential functions and implications of circular RNA in gastrointestinal cancer. Oncol Lett 14:7016\u20137020","journal-title":"Oncol Lett"},{"key":"10963_CR51","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.molcel.2015.03.027","volume":"58","author":"A Rybak-Wolf","year":"2015","unstructured":"Rybak-Wolf A, Stottmeister C, Gla\u017dar P, Jens M, Pino N, Giusti S et al (2015) Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed. Mol Cell 58:870\u2013885. https:\/\/doi.org\/10.1016\/j.molcel.2015.03.027","journal-title":"Mol Cell"},{"key":"10963_CR52","doi-asserted-by":"publisher","first-page":"e1003777","DOI":"10.1371\/journal.pgen.1003777","volume":"9","author":"J Salzman","year":"2013","unstructured":"Salzman J, Chen RE, Olsen MN, Wang PL, Brown PO (2013) Cell-type specific features of circular RNA expression. PLoS Genet 9:e1003777. https:\/\/doi.org\/10.1371\/journal.pgen.1003777","journal-title":"PLoS Genet"},{"key":"10963_CR53","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0169-2607(95)01703-8","volume":"48","author":"F Schoonjans","year":"1995","unstructured":"Schoonjans F, Zalata A, Depuydt CE, Comhaire FH (1995) MedCalc: a new computer program for medical statistics. Comput Methods Programs Biomed 48:257\u2013262","journal-title":"Comput Methods Programs Biomed"},{"issue":"1","key":"10963_CR54","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ejcb.2017.12.001","volume":"97","author":"L Snyers","year":"2018","unstructured":"Snyers L, Erhart R, Laffer S, Pusch O, Weipoltshammer K, Sch\u00f6fer C (2018) LEM4\/ANKLE-2 deficiency impairs post-mitotic re-localization of BAF, LAP2\u03b1 and LaminA to the nucleus, causes nuclear envelope instability in telophase and leads to hyperploidy in HeLa cells. Eur J Cell Biol 97(1):63\u201374. https:\/\/doi.org\/10.1016\/j.ejcb.2017.12.001","journal-title":"Eur J Cell Biol"},{"key":"10963_CR55","first-page":"846","volume":"6","author":"A Sparmann","year":"2006","unstructured":"Sparmann A, Lohuizen M (2006) Polycomb silencers control cell fate, development and cancer. Nature 6:846\u2013856","journal-title":"Nature"},{"key":"10963_CR56","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.celrep.2014.12.002","volume":"10","author":"S Starke","year":"2015","unstructured":"Starke S, Jost I, Rossbach O, Schneider T, Schreiner S, Hung LH et al (2015) Exon circularization requires canonical splice signals. Cell Rep 10:103\u2013111. https:\/\/doi.org\/10.1016\/j.celrep.2014.12.002","journal-title":"Cell Rep"},{"issue":"8","key":"10963_CR57","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/acn3.51629","volume":"9","author":"AX Thomas","year":"2022","unstructured":"Thomas AX et al (2022) ANKLE2-related microcephaly: a variable microcephaly syndrome resembling Zika infection. Ann Clin Transl Neurol 9(8):1276\u20131288","journal-title":"Ann Clin Transl Neurol"},{"key":"10963_CR58","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1242\/dev.128.2.275","volume":"128","author":"F Tie","year":"2001","unstructured":"Tie F, Furuyama T, Prasad-Sinha J, Jane E, Harte PJ (2001) The drosophila polycomb group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3. Development 128:275\u2013286","journal-title":"Development"},{"key":"10963_CR59","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.yexcr.2005.11.013","volume":"312","author":"KE Tifft","year":"2006","unstructured":"Tifft KE, Segura-Totten M, Lee KK, Wilson KL (2006) Barrier-to-autointegration factor-like (BAF-L): a proposed regulator of BAF. Exp Cell Res 312:478\u2013487","journal-title":"Exp Cell Res"},{"key":"10963_CR60","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.cell.2007.03.048","volume":"129","author":"P Trojer","year":"2007","unstructured":"Trojer P, Li G, Sims RJ 3rd, Vaquero A, Kalakonda N, Boccuni P et al (2007) L3MBTL1, a histone-methylation-dependent chromatin lock. Cell 129:915\u2013928","journal-title":"Cell"},{"key":"10963_CR61","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.cub.2004.11.032","volume":"14","author":"JM Turner","year":"2004","unstructured":"Turner JM, Aprelikova O, Xu X, Wang R, Kim S, Chandramouli GV et al (2004) BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. Curr Biol 14:2135\u20132142","journal-title":"Curr Biol"},{"key":"10963_CR62","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/ng1484","volume":"37","author":"JM Turner","year":"2005","unstructured":"Turner JM, Mahadevaiah SK, Fernandez-Capetillo O, Nussenzweig A, Xu X, Deng CX et al (2005) Silencing of unsynapsed meiotic chromosomes in the mouse. Nat Genet 37:41\u201347","journal-title":"Nat Genet"},{"key":"10963_CR63","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/epigenomes3020012","volume":"3","author":"M Vidal","year":"2019","unstructured":"Vidal M (2019) Polycomb assemblies multitask to regulate transcription. Epigenomes 3:12. https:\/\/doi.org\/10.3390\/epigenomes3020012","journal-title":"Epigenomes"},{"key":"10963_CR64","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nature02985","volume":"431","author":"H Wang","year":"2004","unstructured":"Wang H, Wang L, Erdjument-Bromage H, Vidal M, Tempst P, Jones RS, Zhang Y (2004) Role of histone H2A ubiquitination in polycomb silencing. Nature 431:873\u2013878","journal-title":"Nature"},{"key":"10963_CR65","unstructured":"WHO (2010) WHO laboratory manual for the examination and processing of human semen"},{"key":"10963_CR66","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0014-5793(01)02959-3","volume":"507","author":"J Wismar","year":"2001","unstructured":"Wismar J (2001) Molecular characterization of h-l(3)mbt-like: a new member of the human mbt family. FEBS Lett 507:119\u2013121","journal-title":"FEBS Lett"},{"key":"10963_CR67","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0925-4773(95)00431-9","volume":"53","author":"J Wismar","year":"1995","unstructured":"Wismar J, L\u00f6ffler T, Habtemichael N, Vef O, Geissen M, Zirwes R, Altmeyer W, Sass H, Gateff E (1995) The Drosophila melanogaster tumor suppressor gene lethal(3)malignant brain tumor encodes a proline-rich protein with a novel zinc finger. Mech Dev 53:141\u2013154","journal-title":"Mech Dev"},{"issue":"1","key":"10963_CR68","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.cell.2014.09.002","volume":"159","author":"S Yamamoto","year":"2014","unstructured":"Yamamoto S, Jaiswal M, Charng W-L et al (2014) A Drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Cell 159(1):200\u2013214","journal-title":"Cell"},{"issue":"3","key":"10963_CR69","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.juro.2015.08.101","volume":"195","author":"AA Zalata","year":"2016","unstructured":"Zalata AA, Mokhtar N, Atwa A, Khaled M, Shaker OG (2016) The role of protamine 2 gene expression and caspase 9 activity in male infertility. J Urol 195(3):796\u2013800","journal-title":"J Urol"},{"key":"10963_CR70","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.molcel.2007.11.002","volume":"29","author":"W Zhou","year":"2008","unstructured":"Zhou W, Zhu P, Wang J, Pascual G, Ohgi KA, Lozach J, Glass CK, Rosenfeld MG (2008) Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation. Mol Cell 29:69\u201380","journal-title":"Mol Cell"},{"key":"10963_CR71","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.canlet.2018.03.035","volume":"425","author":"R Zhou","year":"2018","unstructured":"Zhou R, Wu Y, Wang W, Su W, Liu Y, Wang Y et al (2018a) Circular RNAs (circRNAs) in cancer. Cancer Lett 425:134\u2013142. https:\/\/doi.org\/10.1016\/j.canlet.2018.03.035","journal-title":"Cancer Lett"},{"key":"10963_CR72","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1261\/rna.067132.118","volume":"24","author":"T Zhou","year":"2018","unstructured":"Zhou T, Xie X, Li M, Shi J, Zhou JJ, Knox KS et al (2018b) Rat body map transcriptomes reveal unique circular RNA features across tissue types and developmental stages. RNA 24:1443\u20131456. https:\/\/doi.org\/10.1261\/rna.067132.118","journal-title":"RNA"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-024-10963-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-024-10963-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-024-10963-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T07:20:40Z","timestamp":1762759240000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10528-024-10963-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,24]]},"references-count":72,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10963"],"URL":"https:\/\/doi.org\/10.1007\/s10528-024-10963-7","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,24]]},"assertion":[{"value":"2 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}