{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:28:20Z","timestamp":1792643300720,"version":"4.5.0"},"reference-count":92,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T00:00:00Z","timestamp":1737763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T00:00:00Z","timestamp":1737763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s10528-024-10976-2","type":"journal-article","created":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T14:51:32Z","timestamp":1737816692000},"page":"1176-1197","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["MicroRNAs' Significance in Retinoblastoma Diagnosis and Treatment: The Little Heroes"],"prefix":"10.1007","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2527-6259","authenticated-orcid":false,"given":"Maryam","family":"Zamani Sani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Mirzaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal","family":"Mohammadian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmira","family":"Aboutalebi Vand Beilankouhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7791-3287","authenticated-orcid":false,"given":"Mohammad","family":"Rahmati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,25]]},"reference":[{"key":"10976_CR1","doi-asserted-by":"publisher","unstructured":"Ahangar Davoodi, N., Najafi, S., Naderi Ghale-Noie, Z., Piranviseh, A., Mollazadeh, S., Ahmadi Asouri, S., Asemi, Z., Morshedi, M., Tamehri Zadeh, S.S., Hamblin, M.R. and Sheida, A., (2022). Role of non-coding RNAs and exosomal non-coding RNAs in retinoblastoma progression. Front Cell Dev Biol. 10, 1065837. https:\/\/doi.org\/10.3389\/fcell.2022.1065837","DOI":"10.3389\/fcell.2022.1065837"},{"issue":"7544","key":"10976_CR2","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nature14281","volume":"519","author":"CR Alarc\u00f3n","year":"2015","unstructured":"Alarc\u00f3n CR, Lee H, Goodarzi H, Halberg N, Tavazoie SF (2015) N 6-methyladenosine marks primary microRNAs for processing. Nature 519(7544):482\u2013485","journal-title":"Nature"},{"key":"10976_CR3","doi-asserted-by":"publisher","unstructured":"Alkatan, H. M., AlQahtani, F. S., & Maktabi, A. M. (2020). Enucleated globes with advanced retinoblastoma correlation of histopathological features and reclassification of tumors according to the 8th edition of the American Joint Committee on Cancer (AJCC). Int Ophthalmol, 40(7), 1739\u20131747. https:\/\/doi.org\/10.1007\/s10792-020-01342-3","DOI":"10.1007\/s10792-020-01342-3"},{"issue":"11","key":"10976_CR4","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.4103\/ijo.IJO_721_20","volume":"68","author":"D Ancona-Lezama","year":"2020","unstructured":"Ancona-Lezama D, Dalvin LA, Shields CL (2020) Modern treatment of retinoblastoma: A 2020 review. Indian J Ophthalmol 68(11):2356\u20132365. https:\/\/doi.org\/10.4103\/ijo.IJO_721_20","journal-title":"Indian J Ophthalmol"},{"issue":"4","key":"10976_CR5","first-page":"161","volume":"2","author":"AM Ardekani","year":"2010","unstructured":"Ardekani AM, Naeini MM (2010) The Role of MicroRNAs in Human Diseases. Avicenna J Med Biotechnol 2(4):161\u2013179","journal-title":"Avicenna J Med Biotechnol"},{"key":"10976_CR6","doi-asserted-by":"crossref","unstructured":"Avvari, S., Prasad, D. K. V., & Khan, I. A. (2022). Role of MicroRNAs in Cell Growth Proliferation and Tumorigenesis. In D. K. V. Prasad & P. Santosh Sushma (Eds.), Role of MicroRNAs in Cancers (pp. 37\u201351). Singapore: Springer Nature Singapore.","DOI":"10.1007\/978-981-16-9186-7_3"},{"issue":"2","key":"10976_CR7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.55705\/cmbr.2022.365396.1085","volume":"3","author":"S Azizi Dargahlou","year":"2023","unstructured":"Azizi Dargahlou S, Iriti M, Pouresmaeil M, Goh LPW (2023) MicroRNAs; their therapeutic and biomarker properties. Cellular, Molecular and Biomedical Reports 3(2):73\u201388","journal-title":"Cellular, Molecular and Biomedical Reports"},{"key":"10976_CR8","doi-asserted-by":"crossref","unstructured":"Becker, W. R., Ober-Reynolds, B., Jouravleva, K., Jolly, S. M., Zamore, P. D., & Greenleaf, W. J. (2019). High-throughput analysis reveals rules for target RNA binding and cleavage by AGO2. Molecular cell, 75(4), 741\u2013755. e711.","DOI":"10.1016\/j.molcel.2019.06.012"},{"issue":"2","key":"10976_CR9","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s12031-017-1017-7","volume":"64","author":"X Che","year":"2018","unstructured":"Che X, Qian Y, Li D (2018) Suppression of Disheveled-Axin Domain Containing 1 (DIXDC1) by MicroRNA-186 Inhibits the Proliferation and Invasion of Retinoblastoma Cells. J Mol Neurosci 64(2):252\u2013261. https:\/\/doi.org\/10.1007\/s12031-017-1017-7","journal-title":"J Mol Neurosci"},{"key":"10976_CR10","doi-asserted-by":"crossref","unstructured":"Chen, S., Chen, X., Luo, Q., Liu, X., Wang, X., Cui, Z., . . . Wu, N. (2021). Retinoblastoma cell-derived exosomes promote angiogenesis of human vesicle endothelial cells through microRNA\u201092a-3p. Cell Death & Disease, 12(7), 1\u201311.","DOI":"10.1038\/s41419-021-03986-0"},{"key":"10976_CR11","doi-asserted-by":"crossref","unstructured":"Chiang, H. R., Schoenfeld, L. W., Ruby, J. G., Auyeung, V. C., Spies, N., Baek, D., . . . Babiarz, J. E. (2010). Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes & development, 24(10), 992\u20131009.","DOI":"10.1101\/gad.1884710"},{"key":"10976_CR12","doi-asserted-by":"crossref","unstructured":"Condrat, C. E., Thompson, D. C., Barbu, M. G., Bugnar, O. L., Boboc, A., Cretoiu, D., . . . Voinea, S. C. (2020). miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis. Cells, 9(2), 276.","DOI":"10.3390\/cells9020276"},{"key":"10976_CR13","doi-asserted-by":"crossref","unstructured":"Cortez, M. A., Anfossi, S., Ramapriyan, R., Menon, H., Atalar, S. C., Aliru, M., . . . Calin, G. A. (2019). Role of miRNAs in immune responses and immunotherapy in cancer. Genes, Chromosomes and Cancer, 58(4), 244\u2013253.","DOI":"10.1002\/gcc.22725"},{"issue":"1","key":"10976_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00432-018-2773-7","volume":"145","author":"LEA Delsin","year":"2019","unstructured":"Delsin LEA, Salomao KB, Pezuk JA, Brassesco MS (2019) Expression profiles and prognostic value of miRNAs in retinoblastoma. J Cancer Res Clin Oncol 145(1):1\u201310. https:\/\/doi.org\/10.1007\/s00432-018-2773-7","journal-title":"J Cancer Res Clin Oncol"},{"issue":"7014","key":"10976_CR15","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature03049","volume":"432","author":"A Denli","year":"2004","unstructured":"Denli A, Tops B, Plasterk R, a, Ketting, RF, & Hannon, GJ, (2004) Processing of primary microRNAs by the Microprocessor complex. Nature 432(7014):231\u2013235","journal-title":"Nature"},{"key":"10976_CR16","doi-asserted-by":"publisher","unstructured":"Doghish, A. S., Moustafa, H. A. M., Elballal, M. S., Sarhan, O. M., Darwish, S. F., Elkalla, W. S., . . . Abulsoud, A. I. (2023). miRNAs as potential game-changers in retinoblastoma: Future clinical and medicinal uses. Pathology - Research and Practice, 247, 154537. https:\/\/doi.org\/10.1016\/j.prp.2023.154537","DOI":"10.1016\/j.prp.2023.154537"},{"issue":"6340","key":"10976_CR17","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1126\/science.aai9372","volume":"356","author":"RA Elbarbary","year":"2017","unstructured":"Elbarbary RA, Miyoshi K, Myers JR, Du P, Ashton JM, Tian B, Maquat LE (2017) Tudor-SN\u2013mediated endonucleolytic decay of human cell microRNAs promotes G1\/S phase transition. Science 356(6340):859\u2013862","journal-title":"Science"},{"key":"10976_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.842509","volume":"13","author":"D Fernandez-Diaz","year":"2022","unstructured":"Fernandez-Diaz D, Rodriguez-Vidal C, Silva-Rodr\u00edguez P, Paniagua L, Blanco-Teijeiro MJ, Pardo M, Bande M (2022) Applications of Non-Coding RNAs in Patients With Retinoblastoma. Front Genet 13:842509. https:\/\/doi.org\/10.3389\/fgene.2022.842509","journal-title":"Front Genet"},{"issue":"5","key":"10976_CR19","doi-asserted-by":"publisher","first-page":"e0197081","DOI":"10.1371\/journal.pone.0197081","volume":"13","author":"JH Francis","year":"2018","unstructured":"Francis JH, Levin AM, Zabor EC, Gobin YP, Abramson DH (2018) Ten-year experience with ophthalmic artery chemosurgery: Ocular and recurrence-free survival. PLoS ONE 13(5):e0197081. https:\/\/doi.org\/10.1371\/journal.pone.0197081","journal-title":"PLoS ONE"},{"issue":"8","key":"10976_CR20","doi-asserted-by":"publisher","first-page":"569","DOI":"10.2174\/1389202921666191217095017","volume":"20","author":"NA Gablo","year":"2019","unstructured":"Gablo NA, Prochazka V, Kala Z, Slaby O, Kiss I (2019) Cell-free microRNAs as non-invasive diagnostic and prognostic bio- markers in pancreatic cancer. Curr Genomics 20(8):569\u2013580. https:\/\/doi.org\/10.2174\/1389202921666191217095017","journal-title":"Curr Genomics"},{"issue":"9","key":"10976_CR21","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/s13258-021-01043-w","volume":"43","author":"M Gao","year":"2021","unstructured":"Gao M, Cui Z, Zhao D, Zhang S, Cai Q (2021) MicroRNA-9 inhibits proliferation and progression in retinoblastoma cells by targeting PTEN. Genes Genomics 43(9):1023\u20131033. https:\/\/doi.org\/10.1007\/s13258-021-01043-w","journal-title":"Genes Genomics"},{"key":"10976_CR22","doi-asserted-by":"crossref","unstructured":"Gerrish, A., Stone, E., Clokie, S., Ainsworth, J. R., Jenkinson, H., McCalla, M., Parulekar, M. (2019). Non-invasive diagnosis of retinoblastoma using cell-free DNA from aqueous humour. British Journal of Ophthalmology, 103(5), 721\u2013724.","DOI":"10.1136\/bjophthalmol-2018-313005"},{"key":"10976_CR23","doi-asserted-by":"publisher","unstructured":"Golabchi, K., Soleimani-Jelodar, R., Aghadoost, N., Momeni, F., Moridikia, A., Nahand, J. S., . . . Mirzaei, H. (2018). MicroRNAs in retinoblastoma: Potential diagnostic and therapeutic biomarkers. J Cell Physiol, 233(4), 3016\u20133023. https:\/\/doi.org\/10.1002\/jcp.26070","DOI":"10.1002\/jcp.26070"},{"issue":"3","key":"10976_CR24","doi-asserted-by":"publisher","first-page":"807","DOI":"10.3892\/ijo.2019.4689","volume":"54","author":"L Guo","year":"2019","unstructured":"Guo L, Bai Y, Ji S, Ma H (2019) MicroRNA-98 suppresses cell growth and invasion of retinoblastoma via targeting the IGF1R\/k-Ras\/Raf\/MEK\/ERK signaling pathway. Int J Oncol 54(3):807\u2013820. https:\/\/doi.org\/10.3892\/ijo.2019.4689","journal-title":"Int J Oncol"},{"key":"10976_CR25","doi-asserted-by":"publisher","unstructured":"Guo, L., Bai, Y., Ni, T., Li, Y., Cao, R., Ji, S., & Li, S. (2021). MicroRNA\u2011153\u20113p suppresses retinoblastoma cell growth and invasion via targeting the IGF1R\/Raf\/MEK and IGF1R\/PI3K\/AKT signaling pathways. Int J Oncol. https:\/\/doi.org\/10.3892\/ijo.2021.5227","DOI":"10.3892\/ijo.2021.5227"},{"issue":"24","key":"10976_CR26","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1101\/gad.1262504","volume":"18","author":"J Han","year":"2004","unstructured":"Han J, Lee Y, Yeom K-H, Kim Y-K, Jin H, Kim VN (2004) The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev 18(24):3016\u20133027","journal-title":"Genes Dev"},{"issue":"6","key":"10976_CR27","first-page":"2615","volume":"53","author":"YX Huang","year":"2018","unstructured":"Huang YX, Nie XG, Li GD, Fan DS, Song LL, Zhang XL (2018) Downregulation of microRNA-182 inhibits cell viability, invasion and angiogenesis in retinoblastoma through inhibition of the PI3K\/AKT pathway and CADM2 upregulation. Int J Oncol 53(6):2615\u20132626","journal-title":"Int J Oncol"},{"issue":"6","key":"10976_CR28","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.2741\/4847","volume":"25","author":"S Ilango","year":"2020","unstructured":"Ilango S, Paital B, Jayachandran P, Padma PR, Nirmaladevi R (2020) Epigenetic alterations in cancer. Front Biosci-Landmark 25(6):1058\u20131109","journal-title":"Front Biosci-Landmark"},{"key":"10976_CR29","doi-asserted-by":"publisher","unstructured":"Jo, D. H., Kim, J. H., Cho, C. S., Cho, Y. L., Jun, H. O., Yu, Y. S., . . . Kim, J. H. (2014). STAT3 inhibition suppresses proliferation of retinoblastoma through down-regulation of positive feedback loop of STAT3\/miR-17\u201392 clusters. Oncotarget, 5(22), 11513\u201311525. https:\/\/doi.org\/10.18632\/oncotarget.2546","DOI":"10.18632\/oncotarget.2546"},{"key":"10976_CR30","doi-asserted-by":"crossref","unstructured":"de Jong, M. C., Kors, W. A., Moll, A. C., de Graaf, P., Castelijns, J. A., Jansen, R. W., . . . Dimaras, H. (2020). Screening for pineal trilateral retinoblastoma revisited: a meta-analysis. Ophthalmology, 127(5), 601\u2013607.","DOI":"10.1016\/j.ophtha.2019.10.040"},{"issue":"8","key":"10976_CR31","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.3390\/cancers12082304","volume":"12","author":"R Kaewkhaw","year":"2020","unstructured":"Kaewkhaw R, Rojanaporn D (2020) Retinoblastoma: etiology, modeling, and treatment. Cancers 12(8):2304","journal-title":"Cancers"},{"key":"10976_CR32","doi-asserted-by":"crossref","unstructured":"Kai, K., Dittmar, R. L., & Sen, S. (2018). Secretory microRNAs as biomarkers of cancer. Paper presented at the Seminars in cell & developmental biology.","DOI":"10.1016\/j.semcdb.2017.12.011"},{"issue":"8","key":"10976_CR33","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1038\/s41433-019-0409-z","volume":"33","author":"S Kaliki","year":"2019","unstructured":"Kaliki S, Mittal P, Mohan S, Chattannavar G, Jajapuram SD, Mohamed A, Palkonda VAR (2019) Bilateral advanced (group D or E) intraocular retinoblastoma: outcomes in 72 Asian Indian patients. Eye (Lond) 33(8):1297\u20131304. https:\/\/doi.org\/10.1038\/s41433-019-0409-z","journal-title":"Eye (Lond)"},{"issue":"1","key":"10976_CR34","doi-asserted-by":"crossref","first-page":"357","DOI":"10.30574\/ijsra.2023.8.1.0046","volume":"8","author":"VR Kankanala","year":"2023","unstructured":"Kankanala VR, Manga S (2023) MicroRNA processing, role of GW182 Scaffolding proteins in RNA interference and Potential roles of let-7, miR-15 and miR-29 families as tumor suppressors. International Journal of Science and Research Archive 8(1):357\u2013366","journal-title":"International Journal of Science and Research Archive"},{"key":"10976_CR35","doi-asserted-by":"publisher","unstructured":"Kara, G., Arun, B., Calin, G. A., & Ozpolat, B. (2022). miRacle of microRNA-Driven Cancer Nanotherapeutics. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers14153818","DOI":"10.3390\/cancers14153818"},{"issue":"1","key":"10976_CR36","doi-asserted-by":"publisher","first-page":"348","DOI":"10.4081\/oncol.2018.348","volume":"12","author":"A Khosravi","year":"2018","unstructured":"Khosravi A, Alizadeh S, Jalili A, Shirzad R, Saki N (2018) The impact of Mir-9 regulation in normal and malignant hematopoiesis. Oncol Rev 12(1):348. https:\/\/doi.org\/10.4081\/oncol.2018.348","journal-title":"Oncol Rev"},{"key":"10976_CR37","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.bios.2017.08.007","volume":"99","author":"T Kilic","year":"2018","unstructured":"Kilic T, Erdem A, Ozsoz M, Carrara S (2018) microRNA biosensors: opportunities and challenges among conventional and commercially available techniques. Biosens Bioelectron 99:525\u2013546","journal-title":"Biosens Bioelectron"},{"issue":"5","key":"10976_CR38","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3892\/etm.2020.9137","volume":"20","author":"L Kong","year":"2020","unstructured":"Kong L, Sun Y, Chen M, Dai Y, Liu Z (2020) Downregulation of microRNA-320a inhibits proliferation and induces apoptosis of retinoblastoma cells via targeting TUSC3. Exp Ther Med 20(5):9. https:\/\/doi.org\/10.3892\/etm.2020.9137","journal-title":"Exp Ther Med"},{"key":"10976_CR39","doi-asserted-by":"publisher","unstructured":"Kooshkaki, O., Rezaei, Z., Rahmati, M., Vahedi, P., Derakhshani, A., Brunetti, O., . . . Baradaran, B. (2020). MiR-144: A New Possible Therapeutic Target and Diagnostic\/Prognostic Tool in Cancers. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21072578","DOI":"10.3390\/ijms21072578"},{"key":"10976_CR40","doi-asserted-by":"crossref","unstructured":"Kothari, P., Marass, F., Yang, J. L., Stewart, C. M., Stephens, D., Patel, J., . . . Enriquez, J. (2020). Cell\u2010free DNA profiling in retinoblastoma patients with advanced intraocular disease: An MSKCC experience. Cancer medicine, 9(17), 6093\u20136101.","DOI":"10.1002\/cam4.3144"},{"issue":"10","key":"10976_CR41","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/iovs.61.10.9","volume":"61","author":"C Li","year":"2020","unstructured":"Li C, Zhao J, Sun W (2020) microRNA-222-Mediated VHL Downregulation Facilitates Retinoblastoma Chemoresistance by Increasing HIF1\u03b1 Expression. Invest Ophthalmol vis Sci 61(10):9. https:\/\/doi.org\/10.1167\/iovs.61.10.9","journal-title":"Invest Ophthalmol vis Sci"},{"key":"10976_CR42","doi-asserted-by":"crossref","unstructured":"Liao, Y., Yin, X., Deng, Y., & Peng, X. (2018). MiR-140-5p suppresses retinoblastoma cell growth via inhibiting c-Met\/AKT\/mTOR pathway. Biosci Rep. Doi: 10.1042\/bsr20180776","DOI":"10.1042\/BSR20180776"},{"issue":"1","key":"10976_CR43","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.clp.2020.12.001","volume":"48","author":"FY Lin","year":"2021","unstructured":"Lin FY, Chintagumpala MM (2021) Neonatal retinoblastoma. Clin Perinatol 48(1):53\u201370","journal-title":"Clin Perinatol"},{"issue":"3","key":"10976_CR44","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1002\/jcb.29453","volume":"121","author":"F Liu","year":"2020","unstructured":"Liu F, Zhang Q, Liang Y (2020) MicroRNA-598 acts as an inhibitor in retinoblastoma through targeting E2F1 and regulating AKT pathway. J Cell Biochem 121(3):2294\u20132302","journal-title":"J Cell Biochem"},{"key":"10976_CR45","doi-asserted-by":"publisher","unstructured":"Liu, S., Zhang, X., Hu, C., Wang, Y., & Xu, C. (2021). [Corrigendum] miR\u201129a inhibits human retinoblastoma progression by targeting STAT3. Oncol Rep, 46(2). https:\/\/doi.org\/10.3892\/or.2021.8126","DOI":"10.3892\/or.2021.8126"},{"issue":"4","key":"10976_CR46","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.jaci.2017.08.034","volume":"141","author":"TX Lu","year":"2018","unstructured":"Lu TX, Rothenberg ME (2018) MicroRNA. Journal of Allergy and Clinical Immunology 141(4):1202\u20131207","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"6","key":"10976_CR47","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.3390\/cimb46060317","volume":"46","author":"X Ma","year":"2024","unstructured":"Ma X, Li X, Sun Q, Luan F, Feng J (2024) Molecular Biological Research on the Pathogenic Mechanism of Retinoblastoma. Curr Issues Mol Biol 46(6):5307\u20135321","journal-title":"Curr Issues Mol Biol"},{"key":"10976_CR48","doi-asserted-by":"crossref","unstructured":"Mendoza, P. R., & Grossniklaus, H. E. (2015). Chapter Thirty - The Biology of Retinoblastoma. In J. F. Hejtmancik & J. M. Nickerson (Eds.), Progress in Molecular Biology and Translational Science (Vol. 134, pp. 503\u2013516): Academic Press.","DOI":"10.1016\/bs.pmbts.2015.06.012"},{"key":"10976_CR49","doi-asserted-by":"crossref","unstructured":"Morris IV, J. P., & McManus, M. T. (2005). Slowing down the Ras lane: miRNAs as tumor suppressors? Science\u2019s STKE, 2005(297), pe41-pe41.","DOI":"10.1126\/stke.2972005pe41"},{"key":"10976_CR50","doi-asserted-by":"crossref","unstructured":"Munier, F. L., Beck-Popovic, M., Chantada, G. L., Cobrinik, D., Kivel\u00e4, T. T., Lohmann, D., . . . Moulin, A. (2019). Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace.\u201cAlive, with good vision and no comorbidity\u201d. Progress in retinal and eye research, 73, 100764.","DOI":"10.1016\/j.preteyeres.2019.05.005"},{"key":"10976_CR51","doi-asserted-by":"publisher","unstructured":"Munier, F. L., Beck-Popovic, M., Chantada, G. L., Cobrinik, D., Kivel\u00e4, T. T., Lohmann, D., . . . Stathopoulos, C. (2019). Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. \"Alive, with good vision and no comorbidity\". Prog Retin Eye Res, 73, 100764. https:\/\/doi.org\/10.1016\/j.preteyeres.2019.05.005","DOI":"10.1016\/j.preteyeres.2019.05.005"},{"key":"10976_CR52","doi-asserted-by":"crossref","unstructured":"Necula, L., Matei, L., Dragu, D., Neagu, A. I., Mambet, C., Nedeianu, S., . . . Chivu-Economescu, M. (2019). Recent advances in gastric cancer early diagnosis. World journal of gastroenterology, 25(17), 2029.","DOI":"10.3748\/wjg.v25.i17.2029"},{"issue":"7","key":"10976_CR53","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3390\/jpm14070723","volume":"14","author":"JB Oehler","year":"2024","unstructured":"Oehler JB, Rajapaksha W, Albrecht H (2024) Emerging applications of nanoparticles in the diagnosis and treatment of breast cancer. Journal of Personalized Medicine 14(7):723","journal-title":"Journal of Personalized Medicine"},{"key":"10976_CR54","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.708765","volume":"11","author":"K Otmani","year":"2021","unstructured":"Otmani K, Lewalle P (2021) Tumor suppressor miRNA in cancer cells and the tumor microenvironment: mechanism of deregulation and clinical implications. Front Oncol 11:708765","journal-title":"Front Oncol"},{"issue":"1","key":"10976_CR55","doi-asserted-by":"publisher","first-page":"15004","DOI":"10.1038\/sigtrans.2015.4","volume":"1","author":"Y Peng","year":"2016","unstructured":"Peng Y, Croce CM (2016) The role of MicroRNAs in human cancer. Signal Transduct Target Ther 1(1):15004. https:\/\/doi.org\/10.1038\/sigtrans.2015.4","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"10976_CR56","doi-asserted-by":"crossref","first-page":"175","DOI":"10.55544\/jrasb.2.6.26","volume":"2","author":"V Rai","year":"2023","unstructured":"Rai V, Gupta Y, Srivastava SP, Shukla A, Bano N, Khan S (2023) Targeted Therapies in Cancer Treatment: Unveiling the Latest Breakthroughs and Promising Approaches. Journal for Research in Applied Sciences and Biotechnology 2(6):175\u2013183","journal-title":"Journal for Research in Applied Sciences and Biotechnology"},{"key":"10976_CR57","unstructured":"Rojanaporn, D., Boontawon, T., Chareonsirisuthigul, T., Thanapanpanich, O., Attaseth, T., Saengwimol, D., . . . Hongeng, S. (2018). Spectrum of germline RB1 mutations and clinical manifestations in retinoblastoma patients from Thailand. Molecular vision, 24, 778."},{"key":"10976_CR58","doi-asserted-by":"crossref","unstructured":"Sait, S. F., Karimi, S., Haque, S., Rebeiz, K. J., Francis, J. H., Marr, B. P., . . . Dunkel, I. J. (2020). A potential role for apparent diffusion coefficient in the diagnosis of trilateral retinoblastoma. Journal of pediatric hematology\/oncology, 42(3), 238.","DOI":"10.1097\/MPH.0000000000001523"},{"key":"10976_CR59","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.822330","volume":"12","author":"P Schaiquevich","year":"2022","unstructured":"Schaiquevich P, Francis JH, Cancela MB, Carcaboso AM, Chantada GL, Abramson DH (2022) Treatment of Retinoblastoma: What Is the Latest and What Is the Future. Front Oncol 12:822330. https:\/\/doi.org\/10.3389\/fonc.2022.822330","journal-title":"Front Oncol"},{"issue":"1","key":"10976_CR60","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3390\/cells9010029","volume":"9","author":"HA Seo","year":"2019","unstructured":"Seo HA, Moeng S, Sim S, Kuh HJ, Choi SY, Park JK (2019) Microrna-based combinatorial cancer therapy: Effects of micrornas on the efficacy of anti-cancer therapies. Cells 9(1):29","journal-title":"Cells"},{"issue":"6","key":"10976_CR61","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.pedhc.2020.06.006","volume":"34","author":"AP Sheehan","year":"2020","unstructured":"Sheehan AP (2020) Retinoblastoma: Early Diagnosis is Crucial. J Pediatr Health Care 34(6):601\u2013605","journal-title":"J Pediatr Health Care"},{"key":"10976_CR62","doi-asserted-by":"crossref","unstructured":"Shields, C. L., Bas, Z., Tadepalli, S., Dalvin, L. A., Rao, R., Schwendeman, R., . . . Leahey, A. (2020). Long-term (20-year) real-world outcomes of intravenous chemotherapy (chemoreduction) for retinoblastoma in 964 eyes of 554 patients at a single centre. British Journal of Ophthalmology, 104(11), 1548\u20131555.","DOI":"10.1136\/bjophthalmol-2019-315572"},{"issue":"1","key":"10976_CR63","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21654","volume":"71","author":"RL Siegel","year":"2021","unstructured":"Siegel RL, Miller KD, Fuchs HE, Jemal A (2021) Cancer statistics, 2021. Ca Cancer J Clin 71(1):7\u201333","journal-title":"Ca Cancer J Clin"},{"issue":"12","key":"10976_CR64","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.18240\/ijo.2018.12.22","volume":"11","author":"L Singh","year":"2018","unstructured":"Singh L, Kashyap S (2018) Update on pathology of retinoblastoma. Int J Ophthalmol 11(12):2011\u20132016. https:\/\/doi.org\/10.18240\/ijo.2018.12.22","journal-title":"Int J Ophthalmol"},{"issue":"8","key":"10976_CR65","doi-asserted-by":"crossref","first-page":"773","DOI":"10.3390\/cells8080773","volume":"8","author":"C Sol\u00e9","year":"2019","unstructured":"Sol\u00e9 C, Molin\u00e9 T, Vidal M, Ordi-Ros J, Cort\u00e9s-Hern\u00e1ndez J (2019) An exosomal urinary miRNA signature for early diagnosis of renal fibrosis in lupus nephritis. Cells 8(8):773","journal-title":"Cells"},{"issue":"3","key":"10976_CR66","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1167\/iovs.61.3.32","volume":"61","author":"L Song","year":"2020","unstructured":"Song L, Huang Y, Zhang X, Han S, Hou M, Li H (2020) Downregulation of microRNA-224-3p Hampers Retinoblastoma Progression via Activation of the Hippo-YAP Signaling Pathway by Increasing LATS2. Invest Ophthalmol vis Sci 61(3):32. https:\/\/doi.org\/10.1167\/iovs.61.3.32","journal-title":"Invest Ophthalmol vis Sci"},{"issue":"4","key":"10976_CR67","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41408-021-00459-7","volume":"11","author":"RC Sterner","year":"2021","unstructured":"Sterner RC, Sterner RM (2021) CAR-T cell therapy: current limitations and potential strategies. Blood Cancer J 11(4):69","journal-title":"Blood Cancer J"},{"issue":"3","key":"10976_CR68","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.3892\/mmr.2018.9784","volume":"19","author":"Z Sun","year":"2019","unstructured":"Sun Z, Zhang A, Zhang L (2019) Inhibition of microRNA-492 attenuates cell proliferation and invasion in retinoblastoma via directly targeting LATS2. Mol Med Rep 19(3):1965\u20131971. https:\/\/doi.org\/10.3892\/mmr.2018.9784","journal-title":"Mol Med Rep"},{"issue":"2","key":"10976_CR69","doi-asserted-by":"publisher","first-page":"325","DOI":"10.18240\/ijo.2020.02.18","volume":"13","author":"J Sun","year":"2020","unstructured":"Sun J, Xi HY, Shao Q, Liu QH (2020) Biomarkers in Retinoblastoma Int J Ophthalmol 13(2):325\u2013341. https:\/\/doi.org\/10.18240\/ijo.2020.02.18","journal-title":"Biomarkers in Retinoblastoma Int J Ophthalmol"},{"key":"10976_CR70","doi-asserted-by":"publisher","unstructured":"Suresh Babu, V., Bisht, A., Mallipatna, A., Sa, D., Dudeja, G., Kannan, R., . . . Ghosh, A. (2022). Enhanced Epithelial-to-Mesenchymal Transition and Chemoresistance in Advanced Retinoblastoma Tumors Is Driven by miR-181a. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers14205124","DOI":"10.3390\/cancers14205124"},{"issue":"2","key":"10976_CR71","doi-asserted-by":"publisher","first-page":"104","DOI":"10.31662\/jmaj.2023-0009","volume":"6","author":"HI Suzuki","year":"2023","unstructured":"Suzuki HI (2023) Roles of MicroRNAs in Disease Biology. Jma j 6(2):104\u2013113. https:\/\/doi.org\/10.31662\/jmaj.2023-0009","journal-title":"Jma j"},{"issue":"2","key":"10976_CR72","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s10456-017-9545-x","volume":"20","author":"JR van Beijnum","year":"2017","unstructured":"van Beijnum JR, Giovannetti E, Poel D, Nowak-Sliwinska P, Griffioen AW (2017) miRNAs: micro-managers of anticancer combination therapies. Angiogenesis 20(2):269\u2013285. https:\/\/doi.org\/10.1007\/s10456-017-9545-x","journal-title":"Angiogenesis"},{"key":"10976_CR73","doi-asserted-by":"publisher","unstructured":"Wan, W., Wan, W., Long, Y., Li, Q., Jin, X., Wan, G., . . . Zhu, Y. (2019). MiR-25\u20133p promotes malignant phenotypes of retinoblastoma by regulating PTEN\/Akt pathway. Biomed Pharmacother, 118, 109111. https:\/\/doi.org\/10.1016\/j.biopha.2019.109111","DOI":"10.1016\/j.biopha.2019.109111"},{"issue":"4","key":"10976_CR74","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.3892\/mmr.2019.9923","volume":"19","author":"L Wang","year":"2019","unstructured":"Wang L, Lyu X, Ma Y, Wu F, Wang L (2019) MicroRNA-504 targets AEG-1 and inhibits cell proliferation and invasion in retinoblastoma. Mol Med Rep 19(4):2935\u20132942. https:\/\/doi.org\/10.3892\/mmr.2019.9923","journal-title":"Mol Med Rep"},{"key":"10976_CR75","doi-asserted-by":"crossref","unstructured":"Warda, O., Naeem, Z., Roelofs, K. A., Sagoo, M. S., & Reddy, M. A. (2022). Retinoblastoma and vision. Eye, 1\u201312.","DOI":"10.1038\/s41433-021-01845-y"},{"key":"10976_CR76","doi-asserted-by":"crossref","unstructured":"Wong, C. K., Gromisch, C., Ozturk, S., Papageorgis, P., Abdolmaleky, H. M., Reinhard, B. M., . . . Thiagalingam, S. (2019). MicroRNA-4417 is a tumor suppressor and prognostic biomarker for triple-negative breast cancer. Cancer biology & therapy, 20(8), 1113\u20131120.","DOI":"10.1080\/15384047.2019.1595285"},{"issue":"7","key":"10976_CR77","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.3390\/ijms20071611","volume":"20","author":"K-L Wu","year":"2019","unstructured":"Wu K-L, Tsai Y-M, Lien C-T, Kuo P-L, Hung J-Y (2019) The roles of MicroRNA in lung cancer. Int J Mol Sci 20(7):1611","journal-title":"Int J Mol Sci"},{"key":"10976_CR78","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cca.2021.01.008","volume":"516","author":"Y Wu","year":"2021","unstructured":"Wu Y, Li Q, Zhang R, Dai X, Chen W, Xing D (2021) Circulating microRNAs: Biomarkers of disease. Clin Chim Acta 516:46\u201354","journal-title":"Clin Chim Acta"},{"issue":"2","key":"10976_CR79","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s00011-020-01432-z","volume":"70","author":"L Xu","year":"2021","unstructured":"Xu L, Zhu S, Tang A, Liu W (2021) LncRNA MBLN1-AS1 inhibits the progression of retinoblastoma through targeting miR-338-5p-Wnt\/\u03b2-catenin signaling pathway. Inflamm Res 70(2):217\u2013227. https:\/\/doi.org\/10.1007\/s00011-020-01432-z","journal-title":"Inflamm Res"},{"key":"10976_CR80","doi-asserted-by":"crossref","first-page":"8653","DOI":"10.2147\/OTT.S212352","volume":"12","author":"L Yang","year":"2019","unstructured":"Yang L, Zhang L, Lu L, Wang Y (2019) Long noncoding RNA SNHG16 sponges miR-182-5p and miR-128-3p to promote retinoblastoma cell migration and invasion by targeting LASP1. Onco Targets Ther 12:8653","journal-title":"Onco Targets Ther"},{"key":"10976_CR81","doi-asserted-by":"crossref","unstructured":"Yang, F., Wei, K., Qin, Z., Liu, W., Shao, C., Wang, C., . . . Shen, H. (2018). MiR-598 suppresses invasion and migration by negative regulation of derlin-1 and epithelial-mesenchymal transition in non-small cell lung cancer. Cellular Physiology and Biochemistry, 47(1), 245\u2013256.","DOI":"10.1159\/000489803"},{"issue":"2","key":"10976_CR82","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.3892\/mmr.2020.11238","volume":"22","author":"W Yin","year":"2020","unstructured":"Yin W, Gao F, Zhang S (2020) MicroRNA-34a inhibits the proliferation and promotes the chemosensitivity of retinoblastoma cells by downregulating Notch1 expression. Mol Med Rep 22(2):1613\u20131620. https:\/\/doi.org\/10.3892\/mmr.2020.11238","journal-title":"Mol Med Rep"},{"issue":"16","key":"10976_CR83","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1177\/15353702211005390","volume":"246","author":"W Yin","year":"2021","unstructured":"Yin W, Wang J, Jiang L, James Kang Y (2021) Cancer and stem cells. Exp Biol Med (Maywood) 246(16):1791\u20131801. https:\/\/doi.org\/10.1177\/15353702211005390","journal-title":"Exp Biol Med (Maywood)"},{"issue":"1","key":"10976_CR84","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nsmb.1733","volume":"17","author":"M Yoda","year":"2010","unstructured":"Yoda M, Kawamata T, Paroo Z, Ye X, Iwasaki S, Liu Q, Tomari Y (2010) ATP-dependent human RISC assembly pathways. Nat Struct Mol Biol 17(1):17\u201323","journal-title":"Nat Struct Mol Biol"},{"key":"10976_CR85","doi-asserted-by":"publisher","unstructured":"Yousef, Y. A., Qaddoumi, I., Al-Nawaiseh, I., Mohammad, M., AlRimawi, D., Toro, M. D., . . . Al-Hussaini, M. (2022). A Proposal for Future Modifications on Clinical TNM Staging System of Retinoblastoma Based on the American Joint Committee on Cancer Staging Manual, 7(th) and 8(th) Editions. J Cancer, 13(4), 1336\u20131345. https:\/\/doi.org\/10.7150\/jca.61005","DOI":"10.7150\/jca.61005"},{"key":"10976_CR86","doi-asserted-by":"crossref","unstructured":"Zacharias, F., George, D., Michail, D., Ioannis, P., Marianna, T., Arzou, B., . . . Emmanuel, K. N. (2020). MicroRNAs determining carcinogenesis by regulating oncogenes and tumor suppressor genes during cell cycle. MicroRNA, 9(2), 82\u201392.","DOI":"10.2174\/22115374MTAwnOTIxw"},{"issue":"3","key":"10976_CR87","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3892\/etm.2021.9686","volume":"21","author":"S Zhang","year":"2021","unstructured":"Zhang S, Cui Z (2021) MicroRNA-34b-5p inhibits proliferation, stemness, migration and invasion of retinoblastoma cells via Notch signaling. Exp Ther Med 21(3):255. https:\/\/doi.org\/10.3892\/etm.2021.9686","journal-title":"Exp Ther Med"},{"issue":"1","key":"10976_CR88","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cell.2004.06.017","volume":"118","author":"H Zhang","year":"2004","unstructured":"Zhang H, Kolb FA, Jaskiewicz L, Westhof E, Filipowicz W (2004) Single processing center models for human Dicer and bacterial RNase III. Cell 118(1):57\u201368","journal-title":"Cell"},{"issue":"3","key":"10976_CR89","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.jconrel.2013.09.015","volume":"172","author":"Y Zhang","year":"2013","unstructured":"Zhang Y, Wang Z, Gemeinhart RA (2013) Progress in microRNA delivery. J Control Release 172(3):962\u2013974. https:\/\/doi.org\/10.1016\/j.jconrel.2013.09.015","journal-title":"J Control Release"},{"issue":"2","key":"10976_CR90","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.3892\/etm.2018.7062","volume":"17","author":"D Zhao","year":"2019","unstructured":"Zhao D, Cui Z (2019) MicroRNA-361-3p regulates retinoblastoma cell proliferation and stemness by targeting hedgehog signaling. Exp Ther Med 17(2):1154\u20131162. https:\/\/doi.org\/10.3892\/etm.2018.7062","journal-title":"Exp Ther Med"},{"key":"10976_CR91","doi-asserted-by":"publisher","unstructured":"Zheng, Q., Zhu, Q., Li, C., Hao, S., Li, J., Yu, X., . . . Pan, Y. (2020). microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma. Clinics (Sao Paulo), 75, e1804. https:\/\/doi.org\/10.6061\/clinics\/2020\/e1804","DOI":"10.6061\/clinics\/2020\/e1804"},{"key":"10976_CR92","doi-asserted-by":"publisher","unstructured":"Zhou, M., Tang, J., Fan, J., Wen, X., Shen, J., Jia, R., . . . Fan, X. (2024). Recent progress in retinoblastoma: Pathogenesis, presentation, diagnosis and management. Asia-Pacific Journal of Ophthalmology, 13(2), 100058. https:\/\/doi.org\/10.1016\/j.apjo.2024.100058","DOI":"10.1016\/j.apjo.2024.100058"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-024-10976-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-024-10976-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-024-10976-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T04:39:25Z","timestamp":1742704765000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10528-024-10976-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,25]]},"references-count":92,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10976"],"URL":"https:\/\/doi.org\/10.1007\/s10528-024-10976-2","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,25]]},"assertion":[{"value":"19 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}