{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:31:52Z","timestamp":1790231512547,"version":"4.1.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Qingdao Park Cultivation Program Project","award":["24-1-5-yqpy-20-qy"],"award-info":[{"award-number":["24-1-5-yqpy-20-qy"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10528-024-11001-2","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T03:03:15Z","timestamp":1735873395000},"page":"42-64","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Diagnostic Value of Circulating microRNAs for Hepatocellular Carcinoma: Results of a Meta-analysis and Validation"],"prefix":"10.1007","volume":"64","author":[{"given":"Bingqiang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junmei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansong","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"11001_CR1","doi-asserted-by":"publisher","first-page":"997","DOI":"10.3855\/jidc.12230","volume":"15","author":"ZS Abdelkhalek","year":"2021","unstructured":"Abdelkhalek ZS, Abdalla MS, Fathy MM, Elbaz TM, Abdelaziz AO, Nabeel MM, Shousha HI, Kamel AH, Kamel MH (2021) Role of circulating microrna-21 and microrna-215 in the diagnosis of hepatitis c related hepatocellular carcinoma. J Infect Dev Countries 15:997\u20131003","journal-title":"J Infect Dev Countries"},{"key":"11001_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jbior.2014.09.013","volume":"57","author":"M Acunzo","year":"2015","unstructured":"Acunzo M, Romano G, Wernicke D, Croce CM (2015) Microrna and cancer\u2014a brief overview. Adv Biol Regul 57:1\u20139. https:\/\/doi.org\/10.1016\/j.jbior.2014.09.013","journal-title":"Adv Biol Regul"},{"key":"11001_CR3","doi-asserted-by":"publisher","first-page":"109","DOI":"10.2478\/jomb-2018-0010","volume":"38","author":"EK Ahmed","year":"2019","unstructured":"Ahmed EK, Fahmy SA, Effat H, Wahab AHA (2019) Circulating mir-210 and mir-1246 as potential biomarkers for differentiating hepatocellular carcinoma from metastatic tumors in the liver. J Med Biochem 38:109\u2013117. https:\/\/doi.org\/10.2478\/jomb-2018-0010","journal-title":"J Med Biochem"},{"key":"11001_CR4","doi-asserted-by":"publisher","first-page":"E51","DOI":"10.1016\/j.clinre.2017.06.004","volume":"41","author":"HEA Ali","year":"2017","unstructured":"Ali HEA, Hanneed RA, Effat H, Ahmed EK, Atef AA, Sharawi SK, Ali M, Elmageed ZYA, Wahab AHA (2017) Circulating micrornas panel as a diagnostic tool for discrimination of hcv-associated hepatocellular carcinoma. Clin Res Hepatol Gastroenterol 41:E51\u2013E62. https:\/\/doi.org\/10.1016\/j.clinre.2017.06.004","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"11001_CR5","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.gene.2015.08.038","volume":"575","author":"KS Amr","year":"2016","unstructured":"Amr KS, Ezzat WM, Elhosary YA, Hegazy AE, Fahim HH, Kamel RR (2016) The potential role of mirnas 21 and 199-a in early diagnosis of hepatocellular carcinoma. Gene 575:66\u201370. https:\/\/doi.org\/10.1016\/j.gene.2015.08.038","journal-title":"Gene"},{"key":"11001_CR6","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.gendis.2017.10.003","volume":"4","author":"KS Amr","year":"2017","unstructured":"Amr KS, Elmawgoud Atia HA, Elazeem Elbnhawy RA, Ezzat WM (2017) Early diagnostic evaluation of mir-122 and mir-224 as biomarkers for hepatocellular carcinoma. Genes Dis 4:215\u2013221. https:\/\/doi.org\/10.1016\/j.gendis.2017.10.003","journal-title":"Genes Dis"},{"key":"11001_CR7","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1055\/s-0034-1397348","volume":"35","author":"M Arrese","year":"2015","unstructured":"Arrese M, Eguchi A, Feldstein AE (2015) Circulating micrornas: emerging biomarkers of liver disease. Semin Liver Dis 35:43\u201354. https:\/\/doi.org\/10.1055\/s-0034-1397348","journal-title":"Semin Liver Dis"},{"key":"11001_CR8","doi-asserted-by":"publisher","first-page":"165","DOI":"10.19193\/0393-6384_2017_1_025","volume":"33","author":"A Balkan","year":"2017","unstructured":"Balkan A, G\u00fclsen MT, Kaya B (2017) Serum microrna-26, microrna-122 and microrna-192 expressions in hepatocellular carcinoma. Acta Medica Mediterranea 33:165\u2013172. https:\/\/doi.org\/10.19193\/0393-6384_2017_1_025","journal-title":"Acta Medica Mediterranea"},{"key":"11001_CR9","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.jceh.2018.07.005","volume":"9","author":"D Bharali","year":"2019","unstructured":"Bharali D, Banerjee BD, Bharadwaj M, Husain SA, Kar P (2019) Expression analysis of microrna-21 and microrna-122 in hepatocellular carcinoma. J Clin Exp Hepatol 9:294\u2013301. https:\/\/doi.org\/10.1016\/j.jceh.2018.07.005","journal-title":"J Clin Exp Hepatol"},{"key":"11001_CR10","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1200\/JCO.2017.77.6385","volume":"36","author":"JR Brahmer","year":"2018","unstructured":"Brahmer JR, Lacchetti C, Schneider BJ, Atkins MB, Brassil KJ, Caterino JM, Chau I, Ernstoff MS, Gardner JM, Ginex P (2018) Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American society of clinical oncology clinical practice guideline. J Clin Oncol 36:1714\u20131768","journal-title":"J Clin Oncol"},{"key":"11001_CR11","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.yexmp.2018.10.009","volume":"106","author":"F Cao","year":"2019","unstructured":"Cao F, Yin L-X (2019) Mir-122 enhances sensitivity of hepatocellular carcinoma to oxaliplatin via inhibiting mdr1 by targeting wnt\/\u03b2-catenin pathway. Exp Mol Pathol 106:34\u201343. https:\/\/doi.org\/10.1016\/j.yexmp.2018.10.009","journal-title":"Exp Mol Pathol"},{"key":"11001_CR12","doi-asserted-by":"publisher","first-page":"283","DOI":"10.23736\/S0031-0808.17.03353-5","volume":"59","author":"GP Caviglia","year":"2017","unstructured":"Caviglia GP, Abate ML, Gaia S, Petrini E, Bosco C, Olivero A, Rosso C, Ciancio A, Pellicano R, Saracco GM, Rizzetto M, Smedile A (2017) Risk of hepatocellular carcinoma in hbv cirrhotic patients assessed by the combination of mir-122, afp and pivka-ii. Panminerva Med 59:283\u2013289. https:\/\/doi.org\/10.23736\/S0031-0808.17.03353-5","journal-title":"Panminerva Med"},{"key":"11001_CR13","doi-asserted-by":"publisher","first-page":"106","DOI":"10.4161\/rna.1.2.1066","volume":"1","author":"J Chang","year":"2014","unstructured":"Chang J, Nicolas E, Marks D, Sander C, Lerro A, Buendia MA, Xu C, Mason WS, Moloshok T, Bort R (2014) Mir-122, a mammalian liver-specific microrna, is processed from hcr mrna and maydownregulate the high affinity cationic amino acid transporter cat-1. RNA Biol 1:106","journal-title":"RNA Biol"},{"key":"11001_CR14","doi-asserted-by":"publisher","first-page":"3997","DOI":"10.3390\/cancers14163997","volume":"14","author":"E Chartampilas","year":"2022","unstructured":"Chartampilas E, Rafailidis V, Georgopoulou V, Kalarakis G, Hatzidakis A, Prassopoulos P (2022) Current imaging diagnosis of hepatocellular carcinoma. Cancers 14:3997","journal-title":"Cancers"},{"key":"11001_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.666306","author":"S Chen","year":"2021","unstructured":"Chen S, Fu Z, Wen S, Yang X, Yu C, Zhou W, Lin Y, Lv Y (2021) Expression and diagnostic value of mir-497 and mir-1246 in hepatocellular carcinoma. Front Genet. https:\/\/doi.org\/10.3389\/fgene.2021.666306","journal-title":"Front Genet"},{"key":"11001_CR16","doi-asserted-by":"publisher","first-page":"3526","DOI":"10.1038\/onc.2009.211","volume":"28","author":"C Coulouarn","year":"2009","unstructured":"Coulouarn C, Factor VM, Andersen JB, Durkin ME, Thorgeirsson SS (2009) Loss of mir-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties. Oncogene 28:3526\u20133536","journal-title":"Oncogene"},{"key":"11001_CR17","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1080\/14737159.2022.2145189","volume":"22","author":"AK da Silva Freire","year":"2022","unstructured":"da Silva Freire AK, de Mendon\u00e7a Belmont TF, Pinto Santiago EJ, Cristina Cordeiro Farias I, do Palmeira K, da Silva AS, Richardson Silva Vasconcelos L (2022) Potential role of circulating mir-21 in the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis. Expert Rev Mol Diagn 22:1037\u20131052","journal-title":"Expert Rev Mol Diagn"},{"key":"11001_CR18","doi-asserted-by":"publisher","first-page":"S108","DOI":"10.1053\/j.gastro.2004.09.023","volume":"127","author":"B Daniele","year":"2004","unstructured":"Daniele B, Bencivenga A, Megna AS, Tinessa V (2004) Alpha-fetoprotein and ultrasonography screening for hepatocellular carcinoma. Gastroenterology 127:S108\u2013112. https:\/\/doi.org\/10.1053\/j.gastro.2004.09.023","journal-title":"Gastroenterology"},{"key":"11001_CR19","doi-asserted-by":"publisher","first-page":"19","DOI":"10.2147\/hmer.S16316","volume":"4","author":"R Dhanasekaran","year":"2012","unstructured":"Dhanasekaran R, Limaye A, Cabrera R (2012) Hepatocellular carcinoma: Current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics. Hepat Med 4:19\u201337. https:\/\/doi.org\/10.2147\/hmer.S16316","journal-title":"Hepat Med"},{"key":"11001_CR20","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.jhep.2005.03.019","volume":"43","author":"AM Di Bisceglie","year":"2005","unstructured":"Di Bisceglie AM, Sterling RK, Chung RT, Everhart JE, Dienstag JL, Bonkovsky HL, Wright EC, Everson GT, Lindsay KL, Lok AS, Lee WM, Morgan TR, Ghany MG, Gretch DR (2005) Serum alpha-fetoprotein levels in patients with advanced hepatitis c: results from the halt-c trial. J Hepatol 43:434\u2013441. https:\/\/doi.org\/10.1016\/j.jhep.2005.03.019","journal-title":"J Hepatol"},{"key":"11001_CR21","doi-asserted-by":"publisher","first-page":"6041","DOI":"10.3748\/wjg.v25.i40.6041","volume":"25","author":"L Di Tommaso","year":"2019","unstructured":"Di Tommaso L, Spadaccini M, Donadon M, Personeni N, Elamin A, Aghemo A, Lleo A (2019) Role of liver biopsy in hepatocellular carcinoma. World J Gastroenterol 25:6041","journal-title":"World J Gastroenterol"},{"key":"11001_CR22","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.7754\/Clin.Lab.2017.170607","volume":"63","author":"R Dumache","year":"2017","unstructured":"Dumache R (2017) Early diagnosis of oral squamous cell carcinoma by salivary micrornas. Clin Lab 63:1771\u20131776. https:\/\/doi.org\/10.7754\/Clin.Lab.2017.170607","journal-title":"Clin Lab"},{"key":"11001_CR23","unstructured":"Dwamena, B.A. (2007) Metaanalytic integration of diagnostic accuracy studies in stata."},{"key":"11001_CR24","unstructured":"Dwamena, B. (2009) Midas: Stata module for meta-analytical integration of diagnostic test accuracy studies."},{"key":"11001_CR25","doi-asserted-by":"publisher","first-page":"221","DOI":"10.5114\/ceh.2023.130547","volume":"9","author":"WK Elabd","year":"2023","unstructured":"Elabd WK, Elbakry MMM, Hassany M, Baki AA, Seoudi DM, Abd El Azeem EM (2023) Evaluation of mirna-7, mirna-10 and mirna-21 as diagnostic non-invasive biomarkers of hepatocellular carcinoma. Clinical and Experimental Hepatology 9:221\u2013227. https:\/\/doi.org\/10.5114\/ceh.2023.130547","journal-title":"Clinical and Experimental Hepatology"},{"key":"11001_CR26","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.5114\/aoms.2019.86621","volume":"15","author":"EGE El-Ahwany","year":"2019","unstructured":"El-Ahwany EGE, Mourad L, Zoheiry MMK, Abu-Taleb H, Hassan M, Atta R, Hassanien M, Zada S (2019) Microrna-122a as a non-invasive biomarker for hcv genotype 4-related hepatocellular carcinoma in egyptian patients. Arch Med Sci 15:1454\u20131461. https:\/\/doi.org\/10.5114\/aoms.2019.86621","journal-title":"Arch Med Sci"},{"key":"11001_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043157","author":"MA Eldosoky","year":"2023","unstructured":"Eldosoky MA, Hammad R, Elmadbouly AA, Aglan RB, Abdel-Hamid SG, Alboraie M, Hassan DA, Shaheen MA, Rushdi A, Ahmed RM, Abdelbadea A, Abdelmageed NA, Elshafei A, Ali E, Abo-Elkheir OI, Zaky S, Hamdy NM, Lambert C (2023) Diagnostic significance of hsa-mir-21\u20135p, hsa-mir-192\u20135p, hsa-mir-155\u20135p, hsa-mir-199a-5p panel and ratios in hepatocellular carcinoma on top of liver cirrhosis in hcv-infected patients. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms24043157","journal-title":"Int J Mol Sci"},{"key":"11001_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.864839","author":"AY Elfert","year":"2022","unstructured":"Elfert AY, Salem A, Abdelhamid AM, Salama A, Sourour DA, Shaker O, Keshk M (2022) Implication of mir-122, mir-483, and mir-335 expression levels as potential signatures in hcv-related hepatocellular carcinoma (hcc) in egyptian patients. Front Mol Biosci. https:\/\/doi.org\/10.3389\/fmolb.2022.864839","journal-title":"Front Mol Biosci"},{"key":"11001_CR29","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24541","author":"Y Fang","year":"2022","unstructured":"Fang Y, Yan D, Wang L, Zhang J, He Q (2022) Circulating micrornas (mir-16, mir-22, mir-122) expression and early diagnosis of hepatocellular carcinoma. J Clin Lab Anal. https:\/\/doi.org\/10.1002\/jcla.24541","journal-title":"J Clin Lab Anal"},{"key":"11001_CR30","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1007\/s12094-020-02514-4","volume":"23","author":"YS Feng","year":"2021","unstructured":"Feng YS, Zhou JM, Sun CH, Zhu J, Yang J, Guo L (2021) The diagnostic value of mir-21 combined with ct in patients with liver cancer. Clin Transl Oncol 23:1238\u20131244. https:\/\/doi.org\/10.1007\/s12094-020-02514-4","journal-title":"Clin Transl Oncol"},{"key":"11001_CR31","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.ajg.2020.08.004","volume":"22","author":"MS Fouda","year":"2021","unstructured":"Fouda MS, Omran MM, Tarek G, Hady A, Abdel Wahab A (2021) Development of a novel panel based on micro-rnas (21, 29a, 200 and 335) and alpha-fetoprotein as diagnostic biomarkers for hepatocellular carcinoma associated with hepatitis c infection. Arab Journal of Gastroenterology 22:28\u201333. https:\/\/doi.org\/10.1016\/j.ajg.2020.08.004","journal-title":"Arab Journal of Gastroenterology"},{"key":"11001_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13102484","author":"T Fruendt","year":"2021","unstructured":"Fruendt T, Krause L, Hussey E, Steinbach B, Koehler D, von Felden J, Schulze K, Lohse AW, Wege H, Schwarzenbach H (2021) Diagnostic and prognostic value of mir-16, mir-146a, mir-192 and mir-221 in exosomes of hepatocellular carcinoma and liver cirrhosis patients. Cancers. https:\/\/doi.org\/10.3390\/cancers13102484","journal-title":"Cancers"},{"key":"11001_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13102484","author":"T Fr\u00fcndt","year":"2021","unstructured":"Fr\u00fcndt T, Krause L, Hussey E, Steinbach B, K\u00f6hler D, von Felden J, Schulze K, Lohse AW, Wege H, Schwarzenbach H (2021) Diagnostic and prognostic value of mir-16, mir-146a, mir-192 and mir-221 in exosomes of hepatocellular carcinoma and liver cirrhosis patients. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers13102484","journal-title":"Cancers (Basel)"},{"key":"11001_CR34","doi-asserted-by":"publisher","first-page":"2934","DOI":"10.1002\/ijc.33111","volume":"147","author":"S Ghosh","year":"2020","unstructured":"Ghosh S, Bhowmik S, Majumdar S, Goswami A, Chakraborty J, Gupta S, Aggarwal S, Ray S, Chatterjee R, Bhattacharyya S, Dutta M, Datta S, Chowdhury A, Dhali GK, Banerjee S (2020) The exosome encapsulatedmicrornasas circulating diagnostic marker for hepatocellular carcinoma with low alpha-fetoprotein. Int J Cancer 147:2934\u20132947. https:\/\/doi.org\/10.1002\/ijc.33111","journal-title":"Int J Cancer"},{"key":"11001_CR35","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.trsl.2018.10.003","volume":"205","author":"L Giannopoulou","year":"2019","unstructured":"Giannopoulou L, Zavridou M, Kasimir-Bauer S, Lianidou ES (2019) Liquid biopsy in ovarian cancer: the potential of circulating mirnas and exosomes. Transl Res 205:77\u201391. https:\/\/doi.org\/10.1016\/j.trsl.2018.10.003","journal-title":"Transl Res"},{"key":"11001_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.mgene.2020.100792","author":"AA Gibriel","year":"2020","unstructured":"Gibriel AA, Al-Anany AM, Al-Arab MAE, Azzazy HME (2020) Investigating circulatory microrna expression profiles in egyptian patients infected with hepatitis c virus mediated hepatic disorders. Meta Gene. https:\/\/doi.org\/10.1016\/j.mgene.2020.100792","journal-title":"Meta Gene"},{"key":"11001_CR37","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.cnc.2022.04.004","volume":"34","author":"H Gilles","year":"2022","unstructured":"Gilles H, Garbutt T, Landrum J (2022) Hepatocellular carcinoma. Crit Care Nurs Clin North Am 34:289\u2013301. https:\/\/doi.org\/10.1016\/j.cnc.2022.04.004","journal-title":"Crit Care Nurs Clin North Am"},{"key":"11001_CR38","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.3748\/wjg.15.1301","volume":"15","author":"AI Gomaa","year":"2009","unstructured":"Gomaa AI, Khan SA, Leen EL, Waked I, Taylor-Robinson SD (2009) Diagnosis of hepatocellular carcinoma. World J Gastroenterol 15:1301\u20131314. https:\/\/doi.org\/10.3748\/wjg.15.1301","journal-title":"World J Gastroenterol"},{"key":"11001_CR39","doi-asserted-by":"publisher","first-page":"6092","DOI":"10.1158\/0008-5472.CAN-06-4607","volume":"67","author":"L Gramantieri","year":"2007","unstructured":"Gramantieri L, Ferracin M, Fornari F, Veronese A, Sabbioni S, Liu CG, Calin GA, Giovannini C, Ferrazzi E, Grazi GL (2007) Cyclin g1 is a target of mir-122a, a microrna frequently down-regulated in human hepatocellular carcinoma. Can Res 67:6092\u20136099","journal-title":"Can Res"},{"key":"11001_CR40","doi-asserted-by":"publisher","first-page":"369","DOI":"10.2147\/JHC.S268292","volume":"8","author":"L Gramantieri","year":"2021","unstructured":"Gramantieri L, Giovannini C, Piscaglia F, Fornari F (2021) Micrornas as modulators of tumor metabolism, microenvironment, and immune response in hepatocellular carcinoma. J Hepatocell Carcinoma 8:369\u2013385","journal-title":"J Hepatocell Carcinoma"},{"key":"11001_CR41","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ncrna.2022.01.004","volume":"7","author":"NSA Gumilas","year":"2022","unstructured":"Gumilas NSA, Widodo I, Ratnasari N, Heriyanto DS (2022) Potential relative quantities of mir-122 and mir-150 to differentiate hepatocellular carcinoma from liver cirrhosis. Non-Coding RNA Res 7:34\u201339","journal-title":"Non-Coding RNA Res"},{"key":"11001_CR42","doi-asserted-by":"publisher","first-page":"44050","DOI":"10.18632\/oncotarget.17211","volume":"8","author":"X Guo","year":"2017","unstructured":"Guo X, Lv X, Lv X, Ma Y, Chen L, Chen Y (2017) Circulating mir-21 serves as a serum biomarker for hepatocellular carcinoma and correlated with distant metastasis. Oncotarget 8:44050","journal-title":"Oncotarget"},{"key":"11001_CR43","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1002\/ijc.29802","volume":"138","author":"CH Hung","year":"2016","unstructured":"Hung CH, Hu TH, Lu SN, Kuo FY, Chen CH, Wang JH, Huang CM, Lee CM, Lin CY, Yen YH, Chiu YC (2016) Circulating micrornas as biomarkers for diagnosis of early hepatocellular carcinoma associated with hepatitis b virus. Int J Cancer 138:714\u2013720. https:\/\/doi.org\/10.1002\/ijc.29802","journal-title":"Int J Cancer"},{"key":"11001_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/s43162-022-00136-6","author":"MA Hussein","year":"2022","unstructured":"Hussein MA, Radwan AFM, Fawzi MM, Rashed LA, Saad EHAI (2022) Microrna 21as a novel biomarker in hepatitis c virus-related hepatocellular carcinoma. Egypt J Internal Med. https:\/\/doi.org\/10.1186\/s43162-022-00136-6","journal-title":"Egypt J Internal Med"},{"key":"11001_CR45","doi-asserted-by":"publisher","first-page":"8379231","DOI":"10.1155\/2023\/8379231","volume":"2023","author":"KQ Huynh","year":"2023","unstructured":"Huynh KQ, Le AT, Phan TT, Ho TT, Pho SP, Nguyen HT, Le BT, Nguyen TT, Nguyen ST (2023) The diagnostic power of circulating mir-1246 in screening cancer: an updated meta-analysis. Oxidat Med Cell Longev 2023:8379231","journal-title":"Oxidat Med Cell Longev"},{"key":"11001_CR46","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1515\/biol-2019-0007","volume":"14","author":"L Jian","year":"2019","unstructured":"Jian L, Sun Q, Wang T, Jin B, Li N (2019) Improving the detection of hepatocellular carcinoma using serum afp expression in combination with gpc3 and micro-rna mir-122 expression. Open Life Sci 14:53\u201361. https:\/\/doi.org\/10.1515\/biol-2019-0007","journal-title":"Open Life Sci"},{"key":"11001_CR47","doi-asserted-by":"publisher","first-page":"10464","DOI":"10.1038\/s41598-019-46872-8","volume":"9","author":"Y Jin","year":"2019","unstructured":"Jin Y, Wong YS, Goh BK, Chan CY, Cheow PC, Chow PK, Lim TK, Goh GB, Krishnamoorthy TL, Kumar R (2019) Circulating micrornas as potential diagnostic and prognostic biomarkers in hepatocellular carcinoma. Sci Rep 9:10464","journal-title":"Sci Rep"},{"key":"11001_CR48","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.bbrc.2017.04.121","volume":"487","author":"J Kim","year":"2017","unstructured":"Kim J, Jiang J, Badawi M, Schmittgen TD (2017) Mir-221 regulates cd44 in hepatocellular carcinoma through the pi3k-akt-mtor pathway. Biochem Biophys Res Commun 487:709\u2013715. https:\/\/doi.org\/10.1016\/j.bbrc.2017.04.121","journal-title":"Biochem Biophys Res Commun"},{"key":"11001_CR49","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.cell.2009.04.021","volume":"137","author":"J Kota","year":"2009","unstructured":"Kota J, Chivukula RR, O\u2019Donnell KA, Wentzel EA, Montgomery CL, Hwang HW, Chang TC, Vivekanandan P, Torbenson M, Clark KR, Mendell JR, Mendell JT (2009) Therapeutic microrna delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137:1005\u20131017. https:\/\/doi.org\/10.1016\/j.cell.2009.04.021","journal-title":"Cell"},{"key":"11001_CR50","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/nrg2843","volume":"11","author":"J Krol","year":"2010","unstructured":"Krol J, Loedige I, Filipowicz W (2010) The widespread regulation of microrna biogenesis, function and decay. Nat Rev Genet 11:597\u2013610. https:\/\/doi.org\/10.1038\/nrg2843","journal-title":"Nat Rev Genet"},{"key":"11001_CR51","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/jcb.20982","volume":"99","author":"H Kutay","year":"2006","unstructured":"Kutay H, Bai S, Datta J, Motiwala T, Pogribny I, Frankel W, Jacob ST, Ghoshal K (2006) Downregulation of mir-122 in the rodent and human hepatocellular carcinomas. J Cell Biochem 99:671","journal-title":"J Cell Biochem"},{"key":"11001_CR52","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1093\/jnci\/djab079","volume":"113","author":"Y-T Lee","year":"2021","unstructured":"Lee Y-T, Wang JJ, Luu M, Noureddin M, Kosari K, Agopian VG, Rich NE, Lu SC, Tseng H-R, Nissen NN (2021) The mortality and overall survival trends of primary liver cancer in the united states. JNCI J Natl Cancer Inst 113:1531\u20131541","journal-title":"JNCI J Natl Cancer Inst"},{"key":"11001_CR53","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1056\/nejm198405313102204","volume":"310","author":"HA Liebman","year":"1984","unstructured":"Liebman HA, Furie BC, Tong MJ, Blanchard RA, Lo KJ, Lee SD, Coleman MS, Furie B (1984) Des-gamma-carboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma. N Engl J Med 310:1427\u20131431. https:\/\/doi.org\/10.1056\/nejm198405313102204","journal-title":"N Engl J Med"},{"key":"11001_CR54","doi-asserted-by":"publisher","first-page":"8626","DOI":"10.26355\/eurrev_202009_22762","volume":"24","author":"D Lin","year":"2020","unstructured":"Lin D, Xu HP, Lin JH, Hu HH, Wang Q, Zhang J (2020) Long non-coding rna miat promotes non-small cell lung cancer progression by sponging mir-1246. Eur Rev Med Pharmacol Sci 24:8626. https:\/\/doi.org\/10.26355\/eurrev_202009_22762","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"11001_CR55","doi-asserted-by":"publisher","DOI":"10.2147\/ott.S44215","author":"J Luo","year":"2013","unstructured":"Luo J, Chen M, Huang H, Yuan T, Zhang M, Zhang K, Deng S (2013) Circulating microrna-122a as a diagnostic marker for hepatocellular carcinoma. Oncotargets Ther. https:\/\/doi.org\/10.2147\/ott.S44215","journal-title":"Oncotargets Ther"},{"key":"11001_CR56","first-page":"990","volume":"11","author":"Z Lv","year":"2018","unstructured":"Lv Z, Tao Y, Cai X, Zhou X, Li Y (2018) Cluster of specified micrornas in tissues and serum as biomarkers for early diagnosis of hepatocellular carcinoma. Int J Clin Exp Pathol 11:990\u2013997","journal-title":"Int J Clin Exp Pathol"},{"key":"11001_CR57","doi-asserted-by":"publisher","first-page":"10513","DOI":"10.1073\/pnas.0804549105","volume":"105","author":"PS Mitchell","year":"2008","unstructured":"Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O\u2019Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB, Tewari M (2008) Circulating micrornas as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 105:10513\u201310518. https:\/\/doi.org\/10.1073\/pnas.0804549105","journal-title":"Proc Natl Acad Sci USA"},{"key":"11001_CR58","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3923\/ijcr.2019.47.57","volume":"15","author":"MA Mohammed","year":"2019","unstructured":"Mohammed MA, Omar NM, Mohammed SA, Amin AM (2019) Serum microrna-1246 as a potential biomarker for hcv-related early-stage hepatocellular carcinoma. Int J Cancer Res 15:47\u201357. https:\/\/doi.org\/10.3923\/ijcr.2019.47.57","journal-title":"Int J Cancer Res"},{"key":"11001_CR59","doi-asserted-by":"publisher","first-page":"15350","DOI":"10.18632\/oncotarget.24601","volume":"9","author":"F Moshiri","year":"2018","unstructured":"Moshiri F, Salvi A, Gramantieri L, Sangiovanni A, Guerriero P, De Petro G, Bassi C, Lupini L, Sattari A, Cheung D, Veneziano D, Nigita G, Shankaraiah RC, Portolani N, Carcoforo P, Fornari F, Bolondi L, Frassoldati A, Sabbioni S, Colombo M, Croce CM, Negrini M (2018) Circulating mir-106b-3p, mir-101\u20133p and mir-1246 as diagnostic biomarkers of hepatocellular carcinoma. Oncotarget 9:15350\u201315364. https:\/\/doi.org\/10.18632\/oncotarget.24601","journal-title":"Oncotarget"},{"key":"11001_CR60","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1038\/sj.onc.1209283","volume":"25","author":"Y Murakami","year":"2006","unstructured":"Murakami Y, Yasuda T, Saigo K, Urashima T, Toyoda H, Okanoue T, Shimotohno K (2006) Comprehensive analysis of microrna expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene 25:2537\u20132545. https:\/\/doi.org\/10.1038\/sj.onc.1209283","journal-title":"Oncogene"},{"key":"11001_CR61","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s13045-015-0162-0","volume":"8","author":"S Naidu","year":"2015","unstructured":"Naidu S, Magee P, Garofalo M (2015) Mirna-based therapeutic intervention of cancer. J Hematol Oncol 8:68. https:\/\/doi.org\/10.1186\/s13045-015-0162-0","journal-title":"J Hematol Oncol"},{"key":"11001_CR62","first-page":"385","volume":"3","author":"M Onishi","year":"2020","unstructured":"Onishi M, Ochiya T, Tanaka Y (2020) Microrna and liver cancer. Cancer Drug Resistance 3:385","journal-title":"Cancer Drug Resistance"},{"key":"11001_CR63","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.dld.2018.12.011","volume":"51","author":"C Peng","year":"2019","unstructured":"Peng C, Ye Y, Wang Z, Guan L, Bao S, Li B, Li W (2019a) Circulating micrornas for the diagnosis of hepatocellular carcinoma. Dig Liver Dis 51:621\u2013631","journal-title":"Dig Liver Dis"},{"key":"11001_CR64","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1186\/s13046-019-1408-4","volume":"38","author":"W Peng","year":"2019","unstructured":"Peng W, Li J, Chen R, Gu Q, Yang P, Qian W, Ji D, Wang Q, Zhang Z, Tang J, Sun Y (2019b) Upregulated mettl3 promotes metastasis of colorectal cancer via mir-1246\/spred2\/mapk signaling pathway. J Exp Clin Cancer Res 38:393. https:\/\/doi.org\/10.1186\/s13046-019-1408-4","journal-title":"J Exp Clin Cancer Res"},{"key":"11001_CR65","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2147\/JHC.S159808","volume":"5","author":"A Quaglia","year":"2018","unstructured":"Quaglia A (2018) Hepatocellular carcinoma: a review of diagnostic challenges for the pathologist. J Hepatocell Carcinoma 5:99\u2013108","journal-title":"J Hepatocell Carcinoma"},{"key":"11001_CR66","doi-asserted-by":"publisher","first-page":"92","DOI":"10.2174\/2211536607666180427165114","volume":"7","author":"NB Quoc","year":"2018","unstructured":"Quoc NB, Phuong NDN, Ngan TK, Linh NTM, Cuong PH, Chau NNB (2018) Expression of plasma hsa-mir122 in hbv-related hepatocellular carcinoma (hcc) in vietnamese patients. Microrna 7:92\u201399. https:\/\/doi.org\/10.2174\/2211536607666180427165114","journal-title":"Microrna"},{"key":"11001_CR67","doi-asserted-by":"publisher","first-page":"638","DOI":"10.7150\/jca.21180","volume":"9","author":"\u00d3 Rapado-Gonz\u00e1lez","year":"2018","unstructured":"Rapado-Gonz\u00e1lez \u00d3, Majem B, Muinelo-Romay L, \u00c1lvarez-Castro A, Santamar\u00eda A, Gil-Moreno A, L\u00f3pez-L\u00f3pez R, Su\u00e1rez-Cunqueiro MM (2018) Human salivary micrornas in cancer. J Cancer 9:638\u2013649. https:\/\/doi.org\/10.7150\/jca.21180","journal-title":"J Cancer"},{"key":"11001_CR68","doi-asserted-by":"publisher","first-page":"3928","DOI":"10.3748\/wjg.v21.i13.3928","volume":"21","author":"SI Seo","year":"2015","unstructured":"Seo SI, Kim HS, Kim WJ, Shin WG, Kim DJ, Kim KH, Jang MK, Lee JH, Kim JS, Kim HY, Kim DJ, Lee MS, Park CK (2015) Diagnostic value of pivka-ii and alpha-fetoprotein in hepatitis b virus-associated hepatocellular carcinoma. World J Gastroenterol 21:3928\u20133935. https:\/\/doi.org\/10.3748\/wjg.v21.i13.3928","journal-title":"World J Gastroenterol"},{"key":"11001_CR69","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.31557\/apjcp.2019.20.8.2515","volume":"20","author":"S Shehab-Eldeen","year":"2019","unstructured":"Shehab-Eldeen S, Nada A, Abou-Elela D, El-Naidany S, Arafat E, Omar T (2019) Diagnostic performance of microrna-122 and microrna-224 in hepatitis c virus-induced hepatocellular carcinoma (hcc). Asian Pac J Cancer Prev: APJCP 20:2515\u20132522. https:\/\/doi.org\/10.31557\/apjcp.2019.20.8.2515","journal-title":"Asian Pac J Cancer Prev: APJCP"},{"key":"11001_CR70","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","volume":"70","author":"RL Siegel","year":"2020","unstructured":"Siegel RL, Miller KD, Jemal A (2020) Cancer statistics, 2020. CA Cancer J Clin 70:7\u201330. https:\/\/doi.org\/10.3322\/caac.21590","journal-title":"CA Cancer J Clin"},{"key":"11001_CR71","doi-asserted-by":"publisher","first-page":"3697","DOI":"10.1002\/jmv.26629","volume":"93","author":"AK Singh","year":"2021","unstructured":"Singh AK, Rooge SB, Varshney A, Vasudevan M, Kumar M, Geffers R, Kumar V, Sarin SK (2021) Identification of mirnas associated with dendritic cell dysfunction during acute and chronic hepatitis b virus infection. J Med Virol 93:3697\u20133706","journal-title":"J Med Virol"},{"key":"11001_CR72","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.1002\/hep.28821","volume":"64","author":"C Stella","year":"2016","unstructured":"Stella C, Kai-Yu N, Man T, Eunice L (2016) Octamer 4\/microrna-1246 signaling axis drives wnt\/\u03b2-catenin activation in liver cancer stem cells. Hepatology 64:2062","journal-title":"Hepatology"},{"key":"11001_CR73","doi-asserted-by":"crossref","unstructured":"Su\u00e1rez, B., C. Sol\u00e9, M. M\u00e1rquez, F. Nanetti and C.H. Lawrie. (2022) Circulating micrornas as cancer biomarkers in liquid biopsies. Systems Biology of MicroRNAs in Cancer: 23\u201373.","DOI":"10.1007\/978-3-031-08356-3_2"},{"key":"11001_CR74","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-08356-3_2","author":"W Tan","year":"2021","unstructured":"Tan W, Li Z, Xia W, Zhu J, Fan R (2021) Mir-221\u20133p regulates hepatocellular carcinoma cell proliferation, migration and invasion via targeting lifr. Ann Hepatol. https:\/\/doi.org\/10.1007\/978-3-031-08356-3_2","journal-title":"Ann Hepatol"},{"key":"11001_CR75","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.cgh.2022.01.047","volume":"21","author":"N Tayob","year":"2023","unstructured":"Tayob N, Kanwal F, Alsarraj A, Hernaez R, El-Serag HB (2023) The performance of afp, afp-3, dcp as biomarkers for detection of hepatocellular carcinoma (hcc): a phase 3 biomarker study in the united states. Clin Gastroenterol Hepatol 21:415\u2013423.e414. https:\/\/doi.org\/10.1016\/j.cgh.2022.01.047","journal-title":"Clin Gastroenterol Hepatol"},{"key":"11001_CR76","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jhep.2011.04.026","volume":"56","author":"Y Tomimaru","year":"2012","unstructured":"Tomimaru Y, Eguchi H, Nagano H, Wada H, Kobayashi S, Marubashi S, Tanemura M, Tomokuni A, Takemasa I, Umeshita K, Kanto T, Doki Y, Mori M (2012) Circulating microrna-21 as a novel biomarker for hepatocellular carcinoma. J Hepatol 56:167\u2013175. https:\/\/doi.org\/10.1016\/j.jhep.2011.04.026","journal-title":"J Hepatol"},{"key":"11001_CR77","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/s0168-8278(00)00053-2","volume":"34","author":"F Trevisani","year":"2001","unstructured":"Trevisani F, D\u2019Intino PE, Morselli-Labate AM, Mazzella G, Accogli E, Caraceni P, Domenicali M, De Notariis S, Roda E, Bernardi M (2001) Serum alpha-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of hbsag and anti-hcv status. J Hepatol 34:570\u2013575. https:\/\/doi.org\/10.1016\/s0168-8278(00)00053-2","journal-title":"J Hepatol"},{"key":"11001_CR78","doi-asserted-by":"publisher","first-page":"3016","DOI":"10.1158\/1078-0432.CCR-18-2849","volume":"25","author":"F Urabe","year":"2019","unstructured":"Urabe F, Matsuzaki J, Yamamoto Y, Kimura T, Hara T, Ichikawa M, Takizawa S, Aoki Y, Niida S, Sakamoto H (2019) Large-scale circulating microrna profiling for the liquid biopsy of prostate cancer. Clin Cancer Res 25:3016\u20133025","journal-title":"Clin Cancer Res"},{"key":"11001_CR79","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1097\/mpa.0000000000000409","volume":"44","author":"J Vaz","year":"2015","unstructured":"Vaz J, Ansari D, Sasor A, Andersson R (2015) Sparc: a potential prognostic and therapeutic target in pancreatic cancer. Pancreas 44:1024\u20131035. https:\/\/doi.org\/10.1097\/mpa.0000000000000409","journal-title":"Pancreas"},{"key":"11001_CR80","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/978-3-030-21540-8_4","volume-title":"Hepatocellular carcinoma: translational precision medicine approaches","author":"N Vietti Violi","year":"2019","unstructured":"Vietti Violi N, Lewis S, Hectors S, Said D, Taouli B (2019) Radiological diagnosis and characterization of hcc. Hepatocellular carcinoma: translational precision medicine approaches. Springer, Cham, pp 71\u201392"},{"key":"11001_CR81","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.canlet.2018.07.019","volume":"434","author":"H Wakasugi","year":"2018","unstructured":"Wakasugi H, Takahashi H, Niinuma T, Kitajima H, Oikawa R, Matsumoto N, Takeba Y, Otsubo T, Takagi M, Ariizumi Y (2018) Dysregulation of mirna in chronic hepatitis b is associated with hepatocellular carcinoma risk after nucleos (t) ide analogue treatment. Cancer Lett 434:91\u2013100","journal-title":"Cancer Lett"},{"key":"11001_CR82","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.3892\/ol.2018.9843","volume":"17","author":"J Wang","year":"2019","unstructured":"Wang J, Chu Y, Xu M, Zhang X, Zhou Y, Xu M (2019) Mir-21 promotes cell migration and invasion of hepatocellular carcinoma by targeting klf5. Oncol Lett 17:2221\u20132227. https:\/\/doi.org\/10.3892\/ol.2018.9843","journal-title":"Oncol Lett"},{"key":"11001_CR83","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12943-023-01870-3","volume":"22","author":"K Wang","year":"2023","unstructured":"Wang K, Wang X, Pan Q, Zhao B (2023) Liquid biopsy techniques and pancreatic cancer: diagnosis, monitoring, and evaluation. Mol Cancer 22:167. https:\/\/doi.org\/10.1186\/s12943-023-01870-3","journal-title":"Mol Cancer"},{"key":"11001_CR84","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.aohep.2019.07.005","volume":"18","author":"X Wei","year":"2019","unstructured":"Wei X, Liu H, Li X, Liu X (2019) Over-expression of mir-122 promotes apoptosis of hepatocellular carcinoma via targeting tlr4. Ann Hepatol 18:869\u2013878. https:\/\/doi.org\/10.1016\/j.aohep.2019.07.005","journal-title":"Ann Hepatol"},{"key":"11001_CR85","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3978\/j.issn.2304-3881.2015.08.05","volume":"5","author":"L Xu","year":"2016","unstructured":"Xu L, Kim Y, Spolverato G, Gani F, Pawlik TM (2016) Racial disparities in treatment and survival of patients with hepatocellular carcinoma in the united states. Hepatobiliary Surg Nutr 5:43\u201352. https:\/\/doi.org\/10.3978\/j.issn.2304-3881.2015.08.05","journal-title":"Hepatobiliary Surg Nutr"},{"key":"11001_CR86","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1002\/hep4.1451","volume":"4","author":"Y Yamamoto","year":"2020","unstructured":"Yamamoto Y, Kondo S, Matsuzaki J, Esaki M, Okusaka T, Shimada K, Murakami Y, Enomoto M, Tamori A, Kato K (2020) Highly sensitive circulating microrna panel for accurate detection of hepatocellular carcinoma in patients with liver disease. Hepatol Commun 4:284\u2013297","journal-title":"Hepatol Commun"},{"key":"11001_CR87","first-page":"21","volume":"32","author":"Q Yang","year":"2022","unstructured":"Yang Q, Wei W, Chen L, Zhong Q, Wang Y (2022) Value of microrna in differential diagnosis of chronic hbv infection and hbv-related liver cancer. Chin J Nosocomiol 32:21\u201325","journal-title":"Chin J Nosocomiol"},{"key":"11001_CR88","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2021.198341","author":"MB Yasser","year":"2021","unstructured":"Yasser MB, Abdellatif M, Emad E, Jafer A, Ahmed S, Nageb L, Abdelshafy H, Al-Anany AM, Al-Arab MAE, Gibriel AA (2021) Circulatory mir-221 & mir-542 expression profiles as potential molecular biomarkers in hepatitis c virus mediated liver cirrhosis and hepatocellular carcinoma. Virus Res. https:\/\/doi.org\/10.1016\/j.virusres.2021.198341","journal-title":"Virus Res"},{"key":"11001_CR89","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.929787","volume":"13","author":"T Yousuf","year":"2022","unstructured":"Yousuf T, Dar SB, Bangri SA, Choh NA, Rasool Z, Shah A, Rather RA, Rah B, Bhat GR, Ali S, Afroze D (2022) Diagnostic implication of a circulating serum-based three-microrna signature in hepatocellular carcinoma. Front Genet 13:929787. https:\/\/doi.org\/10.3389\/fgene.2022.929787","journal-title":"Front Genet"},{"key":"11001_CR90","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1080\/17474124.2018.1453806","volume":"12","author":"G Zhang","year":"2018","unstructured":"Zhang G, Li R, Deng Y, Zhao L (2018) Conditional survival of patients with hepatocellular carcinoma: results from the surveillance, epidemiology, and end results registry. Expert Rev Gastroenterol Hepatol 12:515\u2013523. https:\/\/doi.org\/10.1080\/17474124.2018.1453806","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"11001_CR91","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1012","author":"N Zhang","year":"2019","unstructured":"Zhang N, Hu Z, Qiang Y, Zhu X (2019) Circulating mir-130b- and mir-21-based diagnostic markers and therapeutic targets for hepatocellular carcinoma. Mol Genet Genomic Med. https:\/\/doi.org\/10.1002\/mgg3.1012","journal-title":"Mol Genet Genomic Med"},{"key":"11001_CR92","doi-asserted-by":"publisher","first-page":"e0228857","DOI":"10.1371\/journal.pone.0228857","volume":"15","author":"J Zhang","year":"2020","unstructured":"Zhang J, Chen G, Zhang P, Zhang J, Li X, Gan DN, Cao X, Han M, Du H, Ya Y (2020) The threshold of alpha-fetoprotein (afp) for the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis. PLoS ONE 15:e0228857","journal-title":"PLoS ONE"},{"key":"11001_CR93","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1038\/s41374-019-0270-5","volume":"99","author":"W-T Zhao","year":"2019","unstructured":"Zhao W-T, Lin X-L, Liu Y, Han L-X, Li J, Lin T-Y, Shi J-W, Wang S-C, Lian M, Chen H-W, Sun Y, Xu K, Jia J-S, Luo R-C, Xiao D (2019) Mir-26a promotes hepatocellular carcinoma invasion and metastasis by inhibiting pten and inhibits cell growth by repressing ezh2. Lab Invest 99:1484\u20131500. https:\/\/doi.org\/10.1038\/s41374-019-0270-5","journal-title":"Lab Invest"},{"key":"11001_CR94","first-page":"1","volume":"2020","author":"X-F Zhao","year":"2020","unstructured":"Zhao X-F, Li N, Lin D-D, Sun L-B (2020) Circulating microrna-122 for the diagnosis of hepatocellular carcinoma: a meta-analysis. Biomed Res Int 2020:1\u201310","journal-title":"Biomed Res Int"},{"key":"11001_CR95","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.clinre.2015.11.002","volume":"40","author":"C Zhuang","year":"2016","unstructured":"Zhuang C, Jiang W, Huang D, Xu L, Yang Q, Zheng L, Wang X, Hu L (2016) Serum mir-21, mir-26a and mir-101 as potential biomarkers of hepatocellular carcinoma. Clin Res Hepatol Gastroenterol 40:386\u2013396","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"11001_CR96","doi-asserted-by":"publisher","first-page":"6539","DOI":"10.1007\/s13277-015-4545-1","volume":"37","author":"D Zuo","year":"2016","unstructured":"Zuo D, Chen L, Liu X, Wang X, Xi Q, Luo Y, Zhang N, Guo H (2016) Combination of mir-125b and mir-27a enhances sensitivity and specificity of afp-based diagnosis of hepatocellular carcinoma. Tumor Biol 37:6539\u20136549. https:\/\/doi.org\/10.1007\/s13277-015-4545-1","journal-title":"Tumor Biol"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-024-11001-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-024-11001-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-024-11001-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T05:17:14Z","timestamp":1770441434000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10528-024-11001-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,3]]},"references-count":96,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["11001"],"URL":"https:\/\/doi.org\/10.1007\/s10528-024-11001-2","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,3]]},"assertion":[{"value":"24 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. This study was conducted in accordance with the Declaration of Helsinki. The study was approved by the Ethics Committee of The Second Hospital of Qingdao Municipal Hospital. Informed consent was taken from all the patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}