{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:01:57Z","timestamp":1773414117049,"version":"3.50.1"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10528-025-11037-y","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T02:15:00Z","timestamp":1738808100000},"page":"487-503","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Genetically Proxied SLC12A2 Inhibition and Inflammatory Bowel Disease: A Mendelian Randomization Study"],"prefix":"10.1007","volume":"64","author":[{"given":"Xin","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongsheng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changkun","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengpin","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"issue":"12","key":"11037_CR1","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1038\/s10038-021-00954-6","volume":"66","author":"SM Adadey","year":"2021","unstructured":"Adadey SM et al (2021) Further confirmation of the association of SLC12A2 with non-syndromic autosomal-dominant hearing impairment. J Hum Genet 66(12):1169\u20131175","journal-title":"J Hum Genet"},{"issue":"2","key":"11037_CR2","doi-asserted-by":"publisher","first-page":"C579","DOI":"10.1152\/ajpcell.2001.281.2.C579","volume":"281","author":"F Akar","year":"2001","unstructured":"Akar F et al (2001) Contractile regulation of the Na(+)-K(+)-2Cl(-) cotransporter in vascular smooth muscle. Am J Physiol Cell Physiol 281(2):C579\u2013C584","journal-title":"Am J Physiol Cell Physiol"},{"key":"11037_CR3","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1113\/jphysiol.1988.sp017378","volume":"406","author":"FJ Alvarez-Leefmans","year":"1988","unstructured":"Alvarez-Leefmans FJ et al (1988) Intracellular chloride regulation in amphibian dorsal root ganglion neurones studied with ion-selective microelectrodes. J Physiol 406:225\u2013246","journal-title":"J Physiol"},{"issue":"2","key":"11037_CR4","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/clpt.1983.154","volume":"34","author":"DC Brater","year":"1983","unstructured":"Brater DC et al (1983) Bumetanide and furosemide. Clin Pharmacol Ther 34(2):207\u2013213","journal-title":"Clin Pharmacol Ther"},{"issue":"5 Suppl 1","key":"11037_CR5","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.1097\/01.mcg.0000123991.13937.7e","volume":"38","author":"R Burakoff","year":"2004","unstructured":"Burakoff R (2004) Indeterminate colitis: clinical spectrum of disease. J Clin Gastroenterol 38(5 Suppl 1):S41\u2013S43","journal-title":"J Clin Gastroenterol"},{"issue":"4","key":"11037_CR6","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.crohns.2013.01.010","volume":"7","author":"J Burisch","year":"2013","unstructured":"Burisch J et al (2013) The burden of inflammatory bowel disease in Europe. J Crohns Colitis 7(4):322\u2013337","journal-title":"J Crohns Colitis"},{"issue":"4","key":"11037_CR7","first-page":"232","volume":"69","author":"DG Burns","year":"1986","unstructured":"Burns DG (1986) Smoking in inflammatory bowel disease and the irritable bowel syndrome. S Afr Med J 69(4):232\u2013233","journal-title":"S Afr Med J"},{"key":"11037_CR8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40360-016-0055-z","volume":"17","author":"M Cataldi","year":"2016","unstructured":"Cataldi M et al (2016) Utilization of antihypertensive drugs in obesity-related hypertension: a retrospective observational study in a cohort of patients from Southern Italy. BMC Pharmacol Toxicol 17:9","journal-title":"BMC Pharmacol Toxicol"},{"issue":"6","key":"11037_CR9","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1001\/jamapsychiatry.2021.0005","volume":"78","author":"S Chauquet","year":"2021","unstructured":"Chauquet S et al (2021) Association of antihypertensive drug target genes with psychiatric disorders: a mendelian randomization study. JAMA Psychiat 78(6):623\u2013631","journal-title":"JAMA Psychiat"},{"issue":"4","key":"11037_CR10","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1073\/pnas.1117213109","volume":"109","author":"CY Cui","year":"2012","unstructured":"Cui CY et al (2012) Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1. Proc Natl Acad Sci USA 109(4):1199\u20131203","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"11037_CR11","doi-asserted-by":"publisher","first-page":"a001289","DOI":"10.1101\/mcs.a001289","volume":"2","author":"E Delpire","year":"2016","unstructured":"Delpire E et al (2016) A patient with multisystem dysfunction carries a truncation mutation in human SLC12A2, the gene encoding the Na-K-2Cl cotransporter, NKCC1. Cold Spring Harb Mol Case Stud 2(6):a001289","journal-title":"Cold Spring Harb Mol Case Stud"},{"issue":"4","key":"11037_CR12","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/0360-3016(90)90033-G","volume":"19","author":"LA DeWerd","year":"1990","unstructured":"DeWerd LA et al (1990) Evaluation of a commercial diode monitor for mailed quality control of therapy units. Int J Radiat Oncol Biol Phys 19(4):1053\u20131057","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"11","key":"11037_CR13","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1038\/nm1301","volume":"11","author":"VI Dzhala","year":"2005","unstructured":"Dzhala VI et al (2005) NKCC1 transporter facilitates seizures in the developing brain. Nat Med 11(11):1205\u20131213","journal-title":"Nat Med"},{"issue":"8","key":"11037_CR14","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.2215\/CJN.09630818","volume":"14","author":"DH Ellison","year":"2019","unstructured":"Ellison DH (2019) Clinical pharmacology in diuretic use. Clin J Am Soc Nephrol 14(8):1248\u20131257","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"11037_CR15","doi-asserted-by":"publisher","first-page":"e1003988","DOI":"10.1371\/journal.pmed.1003988","volume":"20","author":"S Fang","year":"2023","unstructured":"Fang S et al (2023) Association between genetically proxied PCSK9 inhibition and prostate cancer risk: a Mendelian randomisation study. PLoS Med 20(1):e1003988","journal-title":"PLoS Med"},{"issue":"40","key":"11037_CR16","doi-asserted-by":"publisher","first-page":"37551","DOI":"10.1074\/jbc.M206294200","volume":"277","author":"AW Flemmer","year":"2002","unstructured":"Flemmer AW et al (2002) Activation of the Na-K-Cl cotransporter NKCC1 detected with a phospho-specific antibody. J Biol Chem 277(40):37551\u201337558","journal-title":"J Biol Chem"},{"issue":"3","key":"11037_CR17","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1165\/rcmb.2015-0238RC","volume":"54","author":"G Flores-Delgado","year":"2016","unstructured":"Flores-Delgado G, Lytle C, Quinton PM (2016) Site of fluid secretion in small airways. Am J Respir Cell Mol Biol 54(3):312\u2013318","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"8","key":"11037_CR18","doi-asserted-by":"publisher","first-page":"C693","DOI":"10.1152\/ajpcell.00350.2012","volume":"304","author":"KB Gagnon","year":"2013","unstructured":"Gagnon KB, Delpire E (2013) Physiology of SLC12 transporters: lessons from inherited human genetic mutations and genetically engineered mouse knockouts. Am J Physiol Cell Physiol 304(8):C693-714","journal-title":"Am J Physiol Cell Physiol"},{"issue":"5","key":"11037_CR19","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1136\/gutjnl-2019-318512","volume":"69","author":"M Garg","year":"2020","unstructured":"Garg M et al (2020) Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target? Gut 69(5):841\u2013851","journal-title":"Gut"},{"issue":"11","key":"11037_CR20","first-page":"786","volume":"17","author":"CE Halstenson","year":"1983","unstructured":"Halstenson CE, Matzke GR (1983) Bumetanide: a new loop diuretic (Bumex, Roche Laboratories). Drug Intell Clin Pharm 17(11):786\u2013797","journal-title":"Drug Intell Clin Pharm"},{"issue":"3","key":"11037_CR21","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1007\/s004240050276","volume":"433","author":"X He","year":"1997","unstructured":"He X et al (1997) Polarized distribution of key membrane transport proteins in the rat submandibular gland. Pflugers Arch 433(3):260\u2013268","journal-title":"Pflugers Arch"},{"issue":"6","key":"11037_CR22","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/s41569-020-00493-1","volume":"18","author":"MV Holmes","year":"2021","unstructured":"Holmes MV et al (2021) Integrating genomics with biomarkers and therapeutic targets to invigorate cardiovascular drug development. Nat Rev Cardiol 18(6):435\u2013453","journal-title":"Nat Rev Cardiol"},{"issue":"1","key":"11037_CR23","doi-asserted-by":"publisher","first-page":"39","DOI":"10.15403\/jgld.2014.1121.251.chr","volume":"25","author":"GE Hume","year":"2016","unstructured":"Hume GE et al (2016) Altered expression of Angiotensinogen and Mediators of Angiogenesis in Ileal crohn\u2019s disease. J Gastrointestin Liver Dis 25(1):39\u201348","journal-title":"J Gastrointestin Liver Dis"},{"issue":"6","key":"11037_CR24","doi-asserted-by":"publisher","first-page":"773","DOI":"10.3109\/14756366.2011.617882","volume":"27","author":"A Husain","year":"2012","unstructured":"Husain A, Madhesia D (2012) Heterocyclic compounds as carbonic anhydrase inhibitor. J Enzyme Inhib Med Chem 27(6):773\u2013783","journal-title":"J Enzyme Inhib Med Chem"},{"issue":"3 Pt 1","key":"11037_CR25","first-page":"G467","volume":"265","author":"CS Hyun","year":"1993","unstructured":"Hyun CS, Binder HJ (1993) Mechanism of leukotriene D4 stimulation of Cl- secretion in rat distal colon in vitro. Am J Physiol 265(3 Pt 1):G467\u2013G473","journal-title":"Am J Physiol"},{"issue":"2","key":"11037_CR26","doi-asserted-by":"publisher","first-page":"164","DOI":"10.15252\/embr.201439263","volume":"16","author":"HE Jakobsson","year":"2015","unstructured":"Jakobsson HE et al (2015) The composition of the gut microbiota shapes the colon mucus barrier. EMBO Rep 16(2):164\u2013177","journal-title":"EMBO Rep"},{"issue":"39","key":"11037_CR27","doi-asserted-by":"publisher","first-page":"15064","DOI":"10.1073\/pnas.0803124105","volume":"105","author":"ME Johansson","year":"2008","unstructured":"Johansson ME et al (2008) The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci USA 105(39):15064\u201315069","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"11037_CR28","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/nrgastro.2015.150","volume":"12","author":"GG Kaplan","year":"2015","unstructured":"Kaplan GG (2015) The global burden of IBD: from 2015 to 2025. Nat Rev Gastroenterol Hepatol 12(12):720\u2013727","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"6","key":"11037_CR29","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s00210-022-02228-0","volume":"395","author":"MCA Kehrenberg","year":"2022","unstructured":"Kehrenberg MCA, Bachmann HS (2022) Diuretics: a contemporary pharmacological classification? Naunyn Schmiedebergs Arch Pharmacol 395(6):619\u2013627","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"4","key":"11037_CR30","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/j.bbrc.2009.01.018","volume":"379","author":"SV Koltsova","year":"2009","unstructured":"Koltsova SV et al (2009) Excitation-contraction coupling in resistance mesenteric arteries: evidence for NKCC1-mediated pathway. Biochem Biophys Res Commun 379(4):1080\u20131083","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"11037_CR31","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.jcmgh.2019.10.006","volume":"9","author":"R Koumangoye","year":"2020","unstructured":"Koumangoye R et al (2020) Novel human NKCC1 mutations cause defects in goblet cell mucus secretion and chronic inflammation. Cell Mol Gastroenterol Hepatol 9(2):239\u2013255","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"6","key":"11037_CR32","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1053\/j.gastro.2004.01.063","volume":"126","author":"EV Loftus Jr","year":"2004","unstructured":"Loftus EV Jr (2004) Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology 126(6):1504\u20131517","journal-title":"Gastroenterology"},{"issue":"32","key":"11037_CR33","doi-asserted-by":"publisher","first-page":"4475","DOI":"10.3748\/wjg.v28.i32.4475","volume":"28","author":"A Loktionov","year":"2022","unstructured":"Loktionov A (2022) Colon mucus in colorectal neoplasia and beyond. World J Gastroenterol 28(32):4475\u20134492","journal-title":"World J Gastroenterol"},{"key":"11037_CR34","unstructured":"Loop Diuretics, in LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. 2012, National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)."},{"key":"11037_CR35","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.2147\/JIR.S353038","volume":"15","author":"Q Lu","year":"2022","unstructured":"Lu Q et al (2022) Immunology of inflammatory bowel disease: molecular mechanisms and therapeutics. J Inflamm Res 15:1825\u20131844","journal-title":"J Inflamm Res"},{"issue":"1","key":"11037_CR36","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3390\/gidisord1010007","volume":"1","author":"AE M\u2019Koma","year":"2019","unstructured":"M\u2019Koma AE (2019) The multifactorial Etiopathogeneses interplay of inflammatory bowel disease: an overview. Gastrointest Disord (Basel) 1(1):75\u2013105","journal-title":"Gastrointest Disord (Basel)"},{"key":"11037_CR37","doi-asserted-by":"publisher","DOI":"10.18103\/mra.v11i1.3135","author":"AE M\u2019Koma","year":"2023","unstructured":"M\u2019Koma AE (2023) Inflammatory bowel disease: clinical diagnosis and pharmaceutical management. Med Res Arch. https:\/\/doi.org\/10.18103\/mra.v11i1.3135","journal-title":"Med Res Arch"},{"issue":"5","key":"11037_CR38","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1002\/humu.23722","volume":"40","author":"EF Macnamara","year":"2019","unstructured":"Macnamara EF et al (2019) Kilquist syndrome: a novel syndromic hearing loss disorder caused by homozygous deletion of SLC12A2. Hum Mutat 40(5):532\u2013538","journal-title":"Hum Mutat"},{"issue":"7","key":"11037_CR39","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1007\/s00268-002-4059-z","volume":"26","author":"JB Matthews","year":"2002","unstructured":"Matthews JB (2002) Molecular regulation of Na+-K+-2Cl- cotransporter (NKCC1) and epithelial chloride secretion. World J Surg 26(7):826\u2013830","journal-title":"World J Surg"},{"issue":"10","key":"11037_CR40","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/S0006-2952(97)00266-9","volume":"54","author":"DF McCole","year":"1997","unstructured":"McCole DF et al (1997) Complement activation of electrogenic ion transport in isolated rat colon. Biochem Pharmacol 54(10):1133\u20131137","journal-title":"Biochem Pharmacol"},{"issue":"5","key":"11037_CR41","first-page":"G1273","volume":"276","author":"N McDaniel","year":"1999","unstructured":"McDaniel N, Lytle C (1999) Parietal cells express high levels of Na-K-2Cl cotransporter on migrating into the gastric gland neck. Am J Physiol 276(5):G1273\u2013G1278","journal-title":"Am J Physiol"},{"issue":"4","key":"11037_CR42","doi-asserted-by":"publisher","first-page":"e1008643","DOI":"10.1371\/journal.pgen.1008643","volume":"16","author":"H Mutai","year":"2020","unstructured":"Mutai H et al (2020) Variants encoding a restricted carboxy-terminal domain of SLC12A2 cause hereditary hearing loss in humans. PLoS Genet 16(4):e1008643","journal-title":"PLoS Genet"},{"issue":"2","key":"11037_CR43","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1467-789X.2006.00226.x","volume":"7","author":"K Narkiewicz","year":"2006","unstructured":"Narkiewicz K (2006) Diagnosis and management of hypertension in obesity. Obes Rev 7(2):155\u2013162","journal-title":"Obes Rev"},{"issue":"10","key":"11037_CR44","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nrgastro.2017.88","volume":"14","author":"J Ni","year":"2017","unstructured":"Ni J et al (2017) Gut microbiota and IBD: causation or correlation? Nat Rev Gastroenterol Hepatol 14(10):573\u2013584","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"11037_CR45","doi-asserted-by":"publisher","first-page":"18014","DOI":"10.1038\/nrdp.2018.14","volume":"4","author":"S Oparil","year":"2018","unstructured":"Oparil S, Acelajado MC, Bakris GL, Berlowitz DR, C\u00edfkov\u00e1 R, Dominiczak AF, Grassi G, Jordan J, Poulter NR, Rodgers A, Whelton PK (2018) Hypertension. Nat Rev Dis Primers 4:18014","journal-title":"Nat Rev Dis Primers"},{"issue":"6","key":"11037_CR46","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1002\/(SICI)1097-4695(19971120)33:6<781::AID-NEU6>3.0.CO;2-5","volume":"33","author":"MD Plotkin","year":"1997","unstructured":"Plotkin MD et al (1997) Expression of the Na-K-2Cl cotransporter is developmentally regulated in postnatal rat brains: a possible mechanism underlying GABA\u2019s excitatory role in immature brain. J Neurobiol 33(6):781\u2013795","journal-title":"J Neurobiol"},{"key":"11037_CR47","doi-asserted-by":"publisher","first-page":"975934","DOI":"10.1155\/2015\/975934","volume":"2015","author":"AH Qavi","year":"2015","unstructured":"Qavi AH, Kamal R, Schrier RW (2015) Clinical use of diuretics in heart failure, cirrhosis, and nephrotic syndrome. Int J Nephrol 2015:975934","journal-title":"Int J Nephrol"},{"issue":"Pt 2","key":"11037_CR48","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1113\/jphysiol.2007.129718","volume":"582","author":"A Reynolds","year":"2007","unstructured":"Reynolds A et al (2007) Dynamic and differential regulation of NKCC1 by calcium and cAMP in the native human colonic epithelium. J Physiol 582(Pt 2):507\u2013524","journal-title":"J Physiol"},{"key":"11037_CR49","doi-asserted-by":"publisher","first-page":"m1203","DOI":"10.1136\/bmj.m1203","volume":"369","author":"TG Richardson","year":"2020","unstructured":"Richardson TG et al (2020) Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study. BMJ 369:m1203","journal-title":"BMJ"},{"issue":"8","key":"11037_CR50","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1097\/HJH.0000000000002089","volume":"37","author":"A Salam","year":"2019","unstructured":"Salam A et al (2019) Efficacy and safety of triple versus dual combination blood pressure-lowering drug therapy: a systematic review and meta-analysis of randomized controlled trials. J Hypertens 37(8):1567\u20131573","journal-title":"J Hypertens"},{"issue":"4 Suppl 2","key":"11037_CR51","doi-asserted-by":"publisher","first-page":"S25","DOI":"10.1681\/ASN.2005121329","volume":"17","author":"A Salvetti","year":"2006","unstructured":"Salvetti A, Ghiadoni L (2006) Thiazide diuretics in the treatment of hypertension: an update. J Am Soc Nephrol 17(4 Suppl 2):S25\u2013S29","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"11037_CR52","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.3390\/nu15081830","volume":"15","author":"X Sang","year":"2023","unstructured":"Sang X, Wang Q, Ning Y, Wang H, Zhang R, Li Y, Fang B, Lv C, Zhang Y, Wang X, Ren F (2023) Age-related mucus barrier dysfunction in mice is related to the changes in Muc2 mucin in the colon. Nutrients 15(8):1830","journal-title":"Nutrients"},{"issue":"20","key":"11037_CR53","doi-asserted-by":"publisher","first-page":"7531","DOI":"10.1523\/JNEUROSCI.20-20-07531.2000","volume":"20","author":"KW Sung","year":"2000","unstructured":"Sung KW et al (2000) Abnormal GABAA receptor-mediated currents in dorsal root ganglion neurons isolated from Na-K-2Cl cotransporter null mice. J Neurosci 20(20):7531\u20137538","journal-title":"J Neurosci"},{"issue":"8","key":"11037_CR54","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1586\/14737175.2015.1066675","volume":"15","author":"CT Supuran","year":"2015","unstructured":"Supuran CT (2015) Acetazolamide for the treatment of idiopathic intracranial hypertension. Expert Rev Neurother 15(8):851\u2013856","journal-title":"Expert Rev Neurother"},{"issue":"9","key":"11037_CR55","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1007\/s00535-018-1437-3","volume":"53","author":"K Suzuki","year":"2018","unstructured":"Suzuki K et al (2018) Single cell analysis of Crohn\u2019s disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties. J Gastroenterol 53(9):1035\u20131047","journal-title":"J Gastroenterol"},{"issue":"2","key":"11037_CR56","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1007\/s11894-012-0244-x","volume":"14","author":"WJ Tremaine","year":"2012","unstructured":"Tremaine WJ (2012) Is indeterminate colitis determinable? Curr Gastroenterol Rep 14(2):162\u2013165","journal-title":"Curr Gastroenterol Rep"},{"key":"11037_CR57","doi-asserted-by":"publisher","first-page":"426","DOI":"10.2165\/00003495-198428050-00003","volume":"28","author":"A Ward","year":"1984","unstructured":"Ward A, Heel RC (1984) Bumetanide: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic use. Drugs 28:426\u2013464","journal-title":"Drugs"},{"issue":"2","key":"11037_CR58","doi-asserted-by":"publisher","first-page":"e1921618","DOI":"10.1001\/jamanetworkopen.2019.21618","volume":"3","author":"J Wei","year":"2020","unstructured":"Wei J et al (2020) Comparison of cardiovascular events among users of different classes of antihypertension medications: a systematic review and network meta-analysis. JAMA Netw Open 3(2):e1921618","journal-title":"JAMA Netw Open"},{"issue":"767","key":"11037_CR59","first-page":"169","volume":"18","author":"G Wuerzner","year":"2022","unstructured":"Wuerzner G, Ponte B, Pech\u00e8re-Bertschi A (2022) Hypertension: novelties 2021. Rev Med Suisse 18(767):169\u2013172","journal-title":"Rev Med Suisse"},{"issue":"1","key":"11037_CR60","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1445-5994.2007.01561.x","volume":"38","author":"JJ Yun","year":"2008","unstructured":"Yun JJ, Cheong I (2008) Mannitol-induced hyperosmolal hyponatraemia. Intern Med J 38(1):73","journal-title":"Intern Med J"},{"issue":"5","key":"11037_CR61","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ng.3538","volume":"48","author":"Z Zhu","year":"2016","unstructured":"Zhu Z et al (2016) Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet 48(5):481\u2013487","journal-title":"Nat Genet"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-025-11037-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-025-11037-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-025-11037-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:03:15Z","timestamp":1773399795000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10528-025-11037-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["11037"],"URL":"https:\/\/doi.org\/10.1007\/s10528-025-11037-y","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5360565\/v1","asserted-by":"object"}]},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]},"assertion":[{"value":"30 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"This study used de-identified public summary-level data that can be downloaded for free. All the GWAS studies utilized in this study were authorized by their respective institutional ethics committees.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval and Consent to Participate"}},{"value":"All the authors agreed to publish the article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}