{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T09:22:24Z","timestamp":1770801744731,"version":"3.50.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Natural Science Foundation Project of Heilongjiang Province","award":["LH2021H112"],"award-info":[{"award-number":["LH2021H112"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82271070"],"award-info":[{"award-number":["82271070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Heilongjiang Provincial Undergraduate Colleges and Universities Central to Support the Reform and Development of Local Colleges and Universities","award":["2020YQ08"],"award-info":[{"award-number":["2020YQ08"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10528-025-11067-6","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T04:09:12Z","timestamp":1740715752000},"page":"967-985","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Downregulation of RORl via STAT3 and P300 Promotes P38 Pathway- Dependent Lens Epithelial Cells Apoptosis in Age-Related Cataract"],"prefix":"10.1007","volume":"64","author":[{"given":"Yue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjiang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoya","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunfei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"issue":"3","key":"11067_CR1","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.biocel.2007.10.034","volume":"40","author":"UP Andley","year":"2008","unstructured":"Andley UP (2008) The lens epithelium: focus on the expression and function of the \u03b1-crystallin chaperones. Int J Biochem Cell Biol 40(3):317\u2013323. https:\/\/doi.org\/10.1016\/j.biocel.2007.10.034","journal-title":"Int J Biochem Cell Biol"},{"issue":"4","key":"11067_CR2","doi-asserted-by":"publisher","first-page":"119450","DOI":"10.1016\/j.bbamcr.2023.119450","volume":"1870","author":"W Anran","year":"2023","unstructured":"Anran W, Zhang W, Zhang G, Ding X, Kang L, Zhou T, Ji M, Guan H (2023) Age-related cataract: GSTP1 ubiquitination and degradation by Parkin inhibits its anti-apoptosis in lens epithelial cells. Biochimica et Biophys Acta BBA Mol Cell Res 1870(4):119450. https:\/\/doi.org\/10.1016\/j.bbamcr.2023.119450","journal-title":"Biochimica et Biophys Acta BBA Mol Cell Res"},{"issue":"2","key":"11067_CR3","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1080\/19390210802332695","volume":"5","author":"R Arora","year":"2008","unstructured":"Arora R, Shikha Singh RK, Sagar RC, Kumar R, Puri SC, Surender S, Prasad J, Gupta ML, Krishna B, Siddiqui MS, Sharma AK, Tripathi RP, Qazi GN, Sharma RK (2008) Radiomodulatory and free-radical scavenging activity of the fractionated aquo-alcoholic extract of the adaptogenic nutraceutical ( Rhodiola imbricata )\u2014a comparative in vitro assessment with ascorbate. J Diet Suppl 5(2):147\u2013163. https:\/\/doi.org\/10.1080\/19390210802332695","journal-title":"J Diet Suppl"},{"issue":"11","key":"11067_CR4","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1007\/s00417-015-3090-3","volume":"253","author":"J Bai","year":"2015","unstructured":"Bai J, Zheng Y, Dong L, Cai X, Wang G, Liu P (2015) Inhibition of p38 mitogen-activated protein kinase phosphorylation decreases H2O2-induced apoptosis in human lens epithelial cells. Graefe\u2019s Arch for Clin and Exp Ophthalmol 253(11):1933\u20131940. https:\/\/doi.org\/10.1007\/s00417-015-3090-3","journal-title":"Graefe\u2019s Arch for Clin and Exp Ophthalmol"},{"key":"11067_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-016-3263-8","author":"J Bai","year":"2016","unstructured":"Bai J, Zheng Y, Liu D, Cai X, Wang G, Liu P (2016) Erratum to: Inhibition of p38 mitogen-activated protein kinase phosphorylation decreases H2O2-induced apoptosis in human lens epithelial cells. Graefes Arch Clin Exp Ophthalmol. https:\/\/doi.org\/10.1007\/s00417-016-3263-8","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"3","key":"11067_CR6","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3390\/cells8030210","volume":"8","author":"M Cetin","year":"2019","unstructured":"Cetin M, Odabas G, Douglas LR, Duriez PJ, Balcik-Ercin P, Yalim-Camci I, Sayan AE, Yagci T (2019) ROR1 expression and its functional significance in hepatocellular carcinoma cells. Cells 8(3):210. https:\/\/doi.org\/10.3390\/cells8030210","journal-title":"Cells"},{"key":"11067_CR7","doi-asserted-by":"publisher","first-page":"144727","DOI":"10.1016\/j.scitotenv.2020.144727","volume":"770","author":"S Chen","year":"2021","unstructured":"Chen S, Yang W, Zhang X, Jin J, Liang C, Wang J, Zhang J (2021) Melamine induces reproductive dysfunction via down-regulated the phosphorylation of p38 and downstream transcription factors Max and Sap1a in mice testes. Sci Total Environ 770:144727. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.144727","journal-title":"Sci Total Environ"},{"issue":"11","key":"11067_CR8","doi-asserted-by":"publisher","first-page":"4935","DOI":"10.7150\/thno.73223","volume":"12","author":"Q Chen","year":"2022","unstructured":"Chen Q, Yang B, Liu X, Zhang XD, Zhang L, Liu T (2022) Histone acetyltransferases CBP\/p300 in tumorigenesis and CBP\/p300 inhibitors as promising novel anticancer agents. Theranostics 12(11):4935\u20134948. https:\/\/doi.org\/10.7150\/thno.73223","journal-title":"Theranostics"},{"issue":"5","key":"11067_CR9","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1111\/febs.17021","volume":"291","author":"T Chen","year":"2024","unstructured":"Chen T, Xiong Y, Deng C, Hu C, Li M, Quan R, Yu X (2024) NDRG2 alleviates photoreceptor apoptosis by regulating the STAT3\/TIMP3\/MMP pathway in mice with retinal degenerative disease. FEBS J 291(5):986\u20131007. https:\/\/doi.org\/10.1111\/febs.17021","journal-title":"FEBS J"},{"issue":"7","key":"11067_CR10","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.jfo.2019.11.009","volume":"43","author":"M Delbarre","year":"2020","unstructured":"Delbarre M, Froussart-Maille F (2020) S\u00e9miologie et formes cliniques de la cataracte chez l\u2019adulte. J Fran\u00e7ais D\u2019ophtalmologie 43(7):653\u2013659. https:\/\/doi.org\/10.1016\/j.jfo.2019.11.009","journal-title":"J Fran\u00e7ais D\u2019ophtalmologie"},{"issue":"10","key":"11067_CR11","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.3390\/cells8101269","volume":"8","author":"CU Dewi","year":"2019","unstructured":"Dewi CU, O\u2019Connor MD (2019) Use of human pluripotent stem cells to define initiating molecular mechanisms of cataract for anti-cataract drug discovery. Cells 8(10):1269. https:\/\/doi.org\/10.3390\/cells8101269","journal-title":"Cells"},{"issue":"4","key":"11067_CR12","doi-asserted-by":"publisher","first-page":"e0224251","DOI":"10.1371\/journal.pone.0224251","volume":"15","author":"S Du","year":"2020","unstructured":"Du S, Shao J, Xie D, Zhang F (2020) Decorin inhibits glucose-induced lens epithelial cell apoptosis via suppressing p22phox-p38 MAPK signaling pathway. PLoS ONE 15(4):e0224251. https:\/\/doi.org\/10.1371\/journal.pone.0224251","journal-title":"PLoS ONE"},{"issue":"14978477","key":"11067_CR13","first-page":"122","volume":"10","author":"S Ebong","year":"2004","unstructured":"Ebong S, Chepelinsky AB, Robinson ML, Zhao H, Yu C, Egwuagu CE (2004) Characterization of the roles of STAT1 and STAT3 signal transduction pathways in mammalian lens development. PubMed 10(14978477):122\u2013131","journal-title":"PubMed"},{"issue":"29782972","key":"11067_CR14","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/j.ijbiomac.2018.05.121","volume":"117","author":"N Fathi","year":"2018","unstructured":"Fathi N, Rashidi G, Khodadadi A, Shahi S, Sharifi S (2018) STAT3 and apoptosis challenges in cancer. Int J Biol Macromol 117(29782972):993\u20131001. https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.05.121","journal-title":"Int J Biol Macromol"},{"issue":"45","key":"11067_CR15","doi-asserted-by":"publisher","first-page":"30725","DOI":"10.1074\/jbc.M805941200","volume":"283","author":"T Hou","year":"2008","unstructured":"Hou T, Ray S, Lee C, Brasier AR (2008) The STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain. J Biol Chem 283(45):30725\u201330734. https:\/\/doi.org\/10.1074\/jbc.M805941200","journal-title":"J Biol Chem"},{"key":"11067_CR16","doi-asserted-by":"publisher","first-page":"110433","DOI":"10.1016\/j.intimp.2023.110433","volume":"121","author":"W Huang","year":"2023","unstructured":"Huang W, Tang H, Liu Y, Li W, Shimu AS, Li B, Zhu C (2023) ROR1\/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-\u03baB signaling pathway. Int Immunopharmacol 121:110433. https:\/\/doi.org\/10.1016\/j.intimp.2023.110433","journal-title":"Int Immunopharmacol"},{"key":"11067_CR17","doi-asserted-by":"publisher","first-page":"116406","DOI":"10.1016\/j.biopha.2024.116406","volume":"173","author":"LJ Huang","year":"2024","unstructured":"Huang LJ, Lan JX, Wang JH, Huang H, Lu K, Zhou ZN, Xin SY, Zhang ZY, Wang JY, Dai P, Chen XM (2024) Bioactivity and mechanism of action of sanguinarine and its derivatives in the past 10 years. Biomed & Pharmacother 173:116406. https:\/\/doi.org\/10.1016\/j.biopha.2024.116406","journal-title":"Biomed & Pharmacother"},{"issue":"2","key":"11067_CR18","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/cas.12858","volume":"107","author":"L Ida","year":"2016","unstructured":"Ida L, Yamaguchi T, Yanagisawa K, Kajino T, Shimada Y, Suzuki M, Takahashi T (2016) Receptor tyrosine kinase-like orphan receptor 1, a target of NKX2-1\/TTF-1 lineage-survival oncogene, inhibits apoptosis signal-regulating kinase 1-mediated pro-apoptotic signaling in lung adenocarcinoma. Cancer Sci 107(2):155\u2013161. https:\/\/doi.org\/10.1111\/cas.12858","journal-title":"Cancer Sci"},{"issue":"2","key":"11067_CR19","doi-asserted-by":"publisher","first-page":"657","DOI":"10.14670\/HH-17.657","volume":"17","author":"R Janknecht","year":"2002","unstructured":"Janknecht R (2002) The versatile functions of the transcriptional coactivators p300 and CBP and their roles in disease. Histol Histopathol 17(2):657\u2013668. https:\/\/doi.org\/10.14670\/HH-17.657","journal-title":"Histol Histopathol"},{"issue":"1","key":"11067_CR20","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/ajcn\/nqy270","volume":"109","author":"H Jiang","year":"2019","unstructured":"Jiang H, Yin Y, Wu C-R, Liu Y, Guo F, Li M, Ma L (2019) Dietary vitamin and carotenoid intake and risk of age-related cataract. Am J Clin Nutr 109(1):43\u201354. https:\/\/doi.org\/10.1093\/ajcn\/nqy270","journal-title":"Am J Clin Nutr"},{"issue":"25660075","key":"11067_CR21","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.exer.2015.02.005","volume":"135","author":"L Kang","year":"2015","unstructured":"Kang L, Zhao W, Zhang G, Wu J, Guan H (2015) Acetylated 8-oxoguanine DNA glycosylase 1 and its relationship with p300 and SIRT1 in lens epithelium cells from age-related cataract. Exp Eye Res 135(25660075):102\u2013108. https:\/\/doi.org\/10.1016\/j.exer.2015.02.005","journal-title":"Exp Eye Res"},{"issue":"2","key":"11067_CR22","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1042\/bst20160272","volume":"45","author":"H Karvonen","year":"2017","unstructured":"Karvonen H, Niininen W, Murum\u00e4gi A, Ungureanu D (2017) Targeting ROR1 identifies new treatment strategies in hematological cancers. Biochem Soc Trans 45(2):457\u2013464. https:\/\/doi.org\/10.1042\/bst20160272","journal-title":"Biochem Soc Trans"},{"key":"11067_CR23","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.m2023.0028","author":"T Lapp","year":"2023","unstructured":"Lapp T, Wacker K, Heinz C, Maier P, Eberwein P, Reinhard T (2023) Cataract surgery\u2014indications, techniques, and intraocular lens selection. Dtsch Arztebl Int. https:\/\/doi.org\/10.3238\/arztebl.m2023.0028","journal-title":"Dtsch Arztebl Int"},{"issue":"9","key":"11067_CR24","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1080\/02713683.2021.1887272","volume":"46","author":"H Li","year":"2021","unstructured":"Li H, Xu L, Song H (2021) MiR-29a alleviates high glucose-induced inflammation and mitochondrial dysfunction via modulation of IL-6\/STAT3 in diabetic cataracts. Curr Eye Res 46(9):1325\u20131332. https:\/\/doi.org\/10.1080\/02713683.2021.1887272","journal-title":"Curr Eye Res"},{"key":"11067_CR27","doi-asserted-by":"publisher","unstructured":"Liu, F (2023) Correlation between ROR1 and MAP1B and Age-related Cataract. J Mudanjiang Med University 44(3): 44\u201347. https:\/\/doi.org\/10.13799\/j.cnki.mdjyxyxb.2023.03.013","DOI":"10.13799\/j.cnki.mdjyxyxb.2023.03.013"},{"key":"11067_CR25","doi-asserted-by":"publisher","first-page":"101112","DOI":"10.1016\/j.preteyeres.2022.101112","volume":"92","author":"Z Liu","year":"2023","unstructured":"Liu Z, Huang S, Zheng Y, Zhou T, Hu L, Xiong L, Liu Y (2023) The lens epithelium as a major determinant in the development, maintenance, and regeneration of the crystalline lens. Prog Retinal and Eye Res 92:101112. https:\/\/doi.org\/10.1016\/j.preteyeres.2022.101112","journal-title":"Prog Retinal and Eye Res"},{"key":"11067_CR26","doi-asserted-by":"publisher","first-page":"112174","DOI":"10.1016\/j.mce.2024.112174","volume":"586","author":"G Liu","year":"2024","unstructured":"Liu G, Shao M, Liu Y (2024) Dichloroacetate ameliorates apoptosis, EMT and oxidative stress in diabetic cataract via inhibiting the IDO1-dependent p38 MAPK pathway. Mol Cell Endocrinol 586:112174. https:\/\/doi.org\/10.1016\/j.mce.2024.112174","journal-title":"Mol Cell Endocrinol"},{"issue":"11","key":"11067_CR28","doi-asserted-by":"publisher","first-page":"9666","DOI":"10.3390\/ijms24119666","volume":"24","author":"J-I Park","year":"2023","unstructured":"Park J-I (2023) MAPK-ERK pathway. Int J Mol Sci 24(11):9666. https:\/\/doi.org\/10.3390\/ijms24119666","journal-title":"Int J Mol Sci"},{"issue":"1","key":"11067_CR29","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s12035-013-8520-9","volume":"49","author":"IM Petrova","year":"2014","unstructured":"Petrova IM, Malessy MJ, Verhaagen J, Fradkin LG, Noordermeer JN (2014) Wnt signaling through the Ror receptor in the nervous system. Mol Neurobiol 49(1):303\u2013315. https:\/\/doi.org\/10.1007\/s12035-013-8520-9","journal-title":"Mol Neurobiol"},{"issue":"1","key":"11067_CR30","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/s41420-023-01527-6","volume":"9","author":"E Piki","year":"2023","unstructured":"Piki E, Dini A, Raivola J, Salokas K, Zhang K, Varjosalo M, Pellinen T, V\u00e4lim\u00e4ki K, Veskim\u00e4e KT, Staff S, Hautaniemi S, Murum\u00e4gi A, Ungureanu D (2023) ROR1-STAT3 signaling contributes to ovarian cancer intra-tumor heterogeneity. Cell Death Discov 9(1):222. https:\/\/doi.org\/10.1038\/s41420-023-01527-6","journal-title":"Cell Death Discov"},{"issue":"1","key":"11067_CR31","doi-asserted-by":"publisher","first-page":"34704","DOI":"10.1038\/srep34704","volume":"6","author":"X Rong","year":"2016","unstructured":"Rong X, Qiu X, Jiang Y, Li D, Xu J, Zhang Y, Lu Y (2016) Effects of histone acetylation on superoxide dismutase 1 gene expression in the pathogenesis of senile cataract. Sci Rep 6(1):34704. https:\/\/doi.org\/10.1038\/srep34704","journal-title":"Sci Rep"},{"issue":"11","key":"11067_CR32","doi-asserted-by":"publisher","first-page":"3078","DOI":"10.4049\/jimmunol.1900389","volume":"203","author":"U Rozovski","year":"2019","unstructured":"Rozovski U, Harris DM, Li P, Liu Z, Jain P, Ferrajoli A, Burger JA, Bose P, Thompson PA, Jain N, Wierda WG, Uziel O, Keating MJ, Estrov Z (2019) STAT3-induced Wnt5a provides chronic lymphocytic leukemia cells with survival advantage. J of Immunol 203(11):3078\u20133085. https:\/\/doi.org\/10.4049\/jimmunol.1900389","journal-title":"J of Immunol"},{"issue":"1","key":"11067_CR33","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1186\/s12885-020-07587-6","volume":"20","author":"G Schiavone","year":"2020","unstructured":"Schiavone G, Epistolio S, Martin V, Molinari F, Barizzi J, Mazzucchelli L, Frattini M, Wannesson L (2020) Functional and clinical significance of ROR1 in lung adenocarcinoma. BMC Cancer 20(1):1085. https:\/\/doi.org\/10.1186\/s12885-020-07587-6","journal-title":"BMC Cancer"},{"key":"11067_CR34","doi-asserted-by":"publisher","first-page":"106657","DOI":"10.1016\/j.dib.2020.106657","volume":"34","author":"R Shparberg","year":"2021","unstructured":"Shparberg R, Dewi CU, Gnanasambandapillai V, Liyanage L, O\u2019Connor MD (2021) Single cell RNA-sequencing data generated from human pluripotent stem cell-derived lens epithelial cells. Data Brief 34:106657. https:\/\/doi.org\/10.1016\/j.dib.2020.106657","journal-title":"Data Brief"},{"issue":"8","key":"11067_CR35","doi-asserted-by":"publisher","first-page":"13833","DOI":"10.3390\/ijms150813833","volume":"15","author":"F Tian","year":"2014","unstructured":"Tian F, Dong L, Zhou Y, Shao Y, Li W, Zhang H, Wang F (2014) Rapamycin-induced apoptosis in HGF-stimulated Lens epithelial cells by AKT\/mTOR, ERK and JAK2\/STAT3 pathways. Int J Mol Sci 15(8):13833\u201313848. https:\/\/doi.org\/10.3390\/ijms150813833","journal-title":"Int J Mol Sci"},{"issue":"6","key":"11067_CR36","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1007\/s13577-021-00582-4","volume":"34","author":"Q Wang","year":"2021","unstructured":"Wang Q, Bing L, Zhang Y, Jing Y, Guo J, Zhou Q, Lv H, Sun Y (2021) STAT3 inhibitor BBI608 enhances the antitumor effect of gefitinib on EGFR-mutated non-small cell lung cancer cells. Human Cell 34(6):1855\u20131865. https:\/\/doi.org\/10.1007\/s13577-021-00582-4","journal-title":"Human Cell"},{"issue":"1","key":"11067_CR37","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s12886-021-01915-5","volume":"21","author":"Z Wang","year":"2021","unstructured":"Wang Z, Dongmei S, Liu S, Zheng G, Zhang G, Tingsong Cui X, Ma ZS, Shanshan H (2021) RNA sequencing and bioinformatics analysis of human lens epithelial cells in age-related cataract. BMC Ophthalmol 21(1):152. https:\/\/doi.org\/10.1186\/s12886-021-01915-5","journal-title":"BMC Ophthalmol"},{"issue":"1","key":"11067_CR38","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1105\/tpc.105.037507","volume":"18","author":"R Xia","year":"2005","unstructured":"Xia R, Wang J, Chunyan Liu Y, Wang YW, Zhai J, Liu J, Hong X, Cao X, Zhu J-K, Gong Z (2005) ROR1\/RPA2A, a putative replication protein A2, functions in epigenetic gene silencing and in regulation of meristem development in Arabidopsis. Plant Cell 18(1):85\u2013103. https:\/\/doi.org\/10.1105\/tpc.105.037507","journal-title":"Plant Cell"},{"issue":"3","key":"11067_CR39","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.ccr.2012.02.008","volume":"21","author":"T Yamaguchi","year":"2012","unstructured":"Yamaguchi T, Yanagisawa K, Sugiyama R, Hosono Y, Shimada Y, Arima C, Kato S, Tomida S, Suzuki M, Osada H, Takahashi T (2012) NKX2\u20131\/TITF1\/TTF-1-induced ROR1 Is required to sustain EGFR survival signaling in lung adenocarcinoma. Cancer Cell 21(3):348\u2013361. https:\/\/doi.org\/10.1016\/j.ccr.2012.02.008","journal-title":"Cancer Cell"},{"issue":"2","key":"11067_CR40","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.gene.2015.09.030","volume":"575","author":"T Yokota","year":"2016","unstructured":"Yokota T, Wang Y (2016) P38 MAP kinases in the heart. Gene 575(2):369\u2013376. https:\/\/doi.org\/10.1016\/j.gene.2015.09.030","journal-title":"Gene"},{"issue":"8","key":"11067_CR41","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1038\/s41416-021-01269-1","volume":"124","author":"W Zhai","year":"2021","unstructured":"Zhai W, Ye X, Wang Y, Feng Y, Wang Y, Lin Y, Ding L, Yang L, Wang X, Kuang Y, Xinyuan F, Eugene Chin Y, Jia B, Zhu B, Ren F, Chang Z (2021) CREPT\/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner. Br J Cancer 124(8):1437\u20131448. https:\/\/doi.org\/10.1038\/s41416-021-01269-1","journal-title":"Br J Cancer"},{"key":"11067_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.680834","author":"Y Zhao","year":"2021","unstructured":"Zhao Y, Zhang D, Guo Y, Lu B, Zhao ZJ, Xu X, Chen Y (2021) Tyrosine kinase ROR1 as a target for anti-cancer therapies. Front Oncol 680834. https:\/\/doi.org\/10.3389\/fonc.2021.680834","journal-title":"Front Oncol"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-025-11067-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-025-11067-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-025-11067-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T05:21:31Z","timestamp":1770441691000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10528-025-11067-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["11067"],"URL":"https:\/\/doi.org\/10.1007\/s10528-025-11067-6","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]},"assertion":[{"value":"20 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Mudanjiang Medical University (No.201934). Mudanjiang Medical University's Animal Care and Use Committee approved all animal research in accordance with the ARVO Statement on Animals in Ophthalmic and Vision Research (No.20220228\u201341).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The participants fully understood the study's content and provided written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}