{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:51:19Z","timestamp":1776437479252,"version":"3.51.2"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s10528-025-11134-y","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T06:39:10Z","timestamp":1747809550000},"page":"2313-2338","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Hub Genes and Pathways Associated with Ageing in Diabetic Encephalopathy Based on Transcriptome Analysis"],"prefix":"10.1007","volume":"64","author":[{"given":"Yonghua","family":"Zong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zekun","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanlin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tonghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"11134_CR1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.73138","author":"B Antal","year":"2022","unstructured":"Antal B, McMahon LP, Sultan SF et al (2022) Type 2 diabetes mellitus accelerates brain aging and cognitive decline: complementary findings from UK biobank and meta-analyses. Elife. https:\/\/doi.org\/10.7554\/eLife.73138","journal-title":"Elife"},{"issue":"1","key":"11134_CR2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/nyas.14020","volume":"1443","author":"S Arguelles","year":"2019","unstructured":"Arguelles S, Guerrero-Castilla A, Cano M et al (2019) Advantages and disadvantages of apoptosis in the aging process. Ann N Y Acad Sci 1443(1):20\u201333","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"11134_CR3","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/1532-429X-14-83","volume":"14","author":"WP Bandettini","year":"2012","unstructured":"Bandettini WP, Kellman P, Mancini C et al (2012) MultiContrast Delayed enhancement (MCODE) improves detection of subendocardial myocardial infarction by late gadolinium enhancement cardiovascular magnetic resonance: a clinical validation study. J Cardiovasc Magn Reson 14(1):83","journal-title":"J Cardiovasc Magn Reson"},{"issue":"4","key":"11134_CR4","first-page":"751","volume":"70","author":"I Belenichev","year":"2023","unstructured":"Belenichev I, Aliyeva O, Popazova O et al (2023) Molecular and biochemical mechanisms of diabetic encephalopathy. Acta Biochim Pol 70(4):751\u2013760","journal-title":"Acta Biochim Pol"},{"issue":"11","key":"11134_CR5","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41582-021-00549-x","volume":"17","author":"BM Bettcher","year":"2021","unstructured":"Bettcher BM, Tansey MG, Dorothee G et al (2021) Peripheral and central immune system crosstalk in Alzheimer disease - a research prospectus. Nat Rev Neurol 17(11):689\u2013701","journal-title":"Nat Rev Neurol"},{"key":"11134_CR6","doi-asserted-by":"publisher","first-page":"114584","DOI":"10.1016\/j.bbr.2023.114584","volume":"452","author":"F Bulut","year":"2023","unstructured":"Bulut F, Adam M, Ozgen A et al (2023) Protective effects of chronic humanin treatment in mice with diabetic encephalopathy: a focus on oxidative stress, inflammation, and apoptosis. Behav Brain Res 452:114584","journal-title":"Behav Brain Res"},{"issue":"1","key":"11134_CR7","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40478-020-01109-y","volume":"9","author":"JJ Bury","year":"2021","unstructured":"Bury JJ, Chambers A, Heath PR et al (2021) Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain. Acta Neuropathol Commun 9(1):5","journal-title":"Acta Neuropathol Commun"},{"issue":"3","key":"11134_CR8","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1007\/s00125-018-4778-9","volume":"62","author":"ML Callisaya","year":"2019","unstructured":"Callisaya ML, Beare R, Moran C et al (2019) Type 2 diabetes mellitus, brain atrophy and cognitive decline in older people: a longitudinal study. Diabetologia 62(3):448\u2013458","journal-title":"Diabetologia"},{"key":"11134_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-024-01112-4","author":"R Casanova","year":"2024","unstructured":"Casanova R, Walker KA, Justice JN et al (2024) Associations of plasma proteomics and age-related outcomes with brain age in a diverse cohort. Geroscience. https:\/\/doi.org\/10.1007\/s11357-024-01112-4","journal-title":"Geroscience"},{"issue":"8","key":"11134_CR10","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.1002\/ptr.7807","volume":"37","author":"J Chen","year":"2023","unstructured":"Chen J, Guo P, Han M et al (2023) Cognitive protection of sinomenine in type 2 diabetes mellitus through regulating the EGF\/Nrf2\/HO-1 signaling, the microbiota-gut-brain axis, and hippocampal neuron ferroptosis. Phytother Res 37(8):3323\u20133341","journal-title":"Phytother Res"},{"issue":"2","key":"11134_CR11","first-page":"213","volume":"53","author":"J Damanik","year":"2021","unstructured":"Damanik J, Yunir E (2021) Type 2 diabetes mellitus and cognitive impairment. Acta Med Indones 53(2):213\u2013220","journal-title":"Acta Med Indones"},{"issue":"D1","key":"11134_CR12","doi-asserted-by":"publisher","first-page":"D1257","DOI":"10.1093\/nar\/gkac833","volume":"51","author":"AP Davis","year":"2023","unstructured":"Davis AP, Wiegers TC, Johnson RJ et al (2023) Comparative toxicogenomics database (CTD): update 2023. Nucleic Acids Res 51(D1):D1257\u2013D1262","journal-title":"Nucleic Acids Res"},{"key":"11134_CR13","doi-asserted-by":"publisher","first-page":"146407","DOI":"10.1016\/j.brainres.2019.146407","volume":"1724","author":"G Ding","year":"2019","unstructured":"Ding G, Chopp M, Li L et al (2019) Differences between normal and diabetic brains in middle-aged rats by MRI. Brain Res 1724:146407","journal-title":"Brain Res"},{"issue":"2","key":"11134_CR14","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1021\/acs.jproteome.8b00702","volume":"18","author":"NT Doncheva","year":"2019","unstructured":"Doncheva NT, Morris JH, Gorodkin J et al (2019) Cytoscape stringapp: network analysis and visualization of proteomics data. J Proteome Res 18(2):623\u2013632","journal-title":"J Proteome Res"},{"issue":"11","key":"11134_CR15","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1002\/alz.12482","volume":"17","author":"A Dove","year":"2021","unstructured":"Dove A, Shang Y, Xu W et al (2021) The impact of diabetes on cognitive impairment and its progression to dementia. Alzheimers Dement 17(11):1769\u20131778","journal-title":"Alzheimers Dement"},{"key":"11134_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116144","author":"H Ehtewish","year":"2022","unstructured":"Ehtewish H, Arredouani A, El-Agnaf O (2022) Diagnostic, prognostic, and mechanistic biomarkers of diabetes mellitus-associated cognitive decline. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23116144","journal-title":"Int J Mol Sci"},{"issue":"W1","key":"11134_CR17","doi-asserted-by":"publisher","first-page":"W60","DOI":"10.1093\/nar\/gky311","volume":"46","author":"M Franz","year":"2018","unstructured":"Franz M, Rodriguez H, Lopes C et al (2018) GeneMANIA update 2018. Nucleic Acids Res 46(W1):W60\u2013W64","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"11134_CR18","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1111\/jgs.16321","volume":"68","author":"M Ganguli","year":"2020","unstructured":"Ganguli M, Beer JC, Zmuda JM et al (2020) Aging, diabetes, obesity, and cognitive decline: a population-based study. J Am Geriatr Soc 68(5):991\u2013998","journal-title":"J Am Geriatr Soc"},{"issue":"1","key":"11134_CR19","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s12974-019-1532-2","volume":"16","author":"PJ Hallett","year":"2019","unstructured":"Hallett PJ, Engelender S, Isacson O (2019) Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson\u2019s disease. J Neuroinflammation 16(1):153","journal-title":"J Neuroinflammation"},{"key":"11134_CR20","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/s41586-024-07185-7","volume":"628","author":"MS Haney","year":"2024","unstructured":"Haney MS, Palovics R, Munson CN et al (2024) APOE4\/4 is linked to damaging lipid droplets in Alzheimer\u2019s disease microglia. Nature 628:154\u201361","journal-title":"Nature"},{"issue":"4","key":"11134_CR21","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1080\/13697137.2021.1877652","volume":"24","author":"CE Hugenschmidt","year":"2021","unstructured":"Hugenschmidt CE, Duran T, Espeland MA (2021) Interactions between estradiol, diabetes, and brain aging and the risk for cognitive impairment. Climacteric 24(4):359\u2013365","journal-title":"Climacteric"},{"issue":"1","key":"11134_CR22","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s41593-020-00745-w","volume":"24","author":"WN Jin","year":"2021","unstructured":"Jin WN, Shi K, He W et al (2021) Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition. Nat Neurosci 24(1):61\u201373","journal-title":"Nat Neurosci"},{"key":"11134_CR23","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12979-020-00187-9","volume":"17","author":"A Kale","year":"2020","unstructured":"Kale A, Sharma A, Stolzing A et al (2020) Role of immune cells in the removal of deleterious senescent cells. Immun Ageing 17:16","journal-title":"Immun Ageing"},{"key":"11134_CR24","doi-asserted-by":"publisher","first-page":"645593","DOI":"10.3389\/fcell.2021.645593","volume":"9","author":"R Kumari","year":"2021","unstructured":"Kumari R, Jat P (2021) Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype. Front Cell Dev Biol 9:645593","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"11134_CR25","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1111\/jnc.14610","volume":"149","author":"R Kushwaha","year":"2019","unstructured":"Kushwaha R, Mishra J, Gupta AP et al (2019) Rosiglitazone up-regulates glial fibrillary acidic protein via HB-EGF secreted from astrocytes and neurons through PPARgamma pathway and reduces apoptosis in high-fat diet-fed mice. J Neurochem 149(5):679\u2013698","journal-title":"J Neurochem"},{"issue":"9","key":"11134_CR26","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1161\/CIRCRESAHA.111.246116","volume":"110","author":"J Lahteenvuo","year":"2012","unstructured":"Lahteenvuo J, Rosenzweig A (2012) Effects of aging on angiogenesis. Circ Res 110(9):1252\u20131264","journal-title":"Circ Res"},{"key":"11134_CR27","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/978-1-4939-6658-5_19","volume":"1533","author":"Z Li","year":"2017","unstructured":"Li Z, Zhao Y, Liu X et al (2017) Construction of the leaf senescence database and functional assessment of senescence-associated genes. Methods Mol Biol 1533:315\u2013333","journal-title":"Methods Mol Biol"},{"key":"11134_CR28","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/978-981-99-1627-6_9","volume":"1419","author":"M Li","year":"2023","unstructured":"Li M, An H, Wang W et al (2023) Biomolecular Markers of Brain Aging. Adv Exp Med Biol 1419:111\u2013126","journal-title":"Adv Exp Med Biol"},{"key":"11134_CR29","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.arr.2017.12.005","volume":"42","author":"Y Liu","year":"2018","unstructured":"Liu Y, Li M, Zhang Z et al (2018) Role of microglia-neuron interactions in diabetic encephalopathy. Ageing Res Rev 42:28\u201339","journal-title":"Ageing Res Rev"},{"key":"11134_CR30","doi-asserted-by":"publisher","first-page":"928591","DOI":"10.3389\/fendo.2022.928591","volume":"13","author":"P Liu","year":"2022","unstructured":"Liu P, Yang X, Niu J et al (2022) Hyperglycemia aggravates ischemic brain damage via ERK1\/2 activated cell autophagy and mitochondrial fission. Front Endocrinol (Lausanne) 13:928591","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"11134_CR31","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1038\/s41598-020-79235-9","volume":"11","author":"H Ma","year":"2021","unstructured":"Ma H, He Z, Chen J et al (2021) Identifying of biomarkers associated with gastric cancer based on 11 topological analysis methods of CytoHubba. Sci Rep 11(1):1331","journal-title":"Sci Rep"},{"key":"11134_CR32","doi-asserted-by":"publisher","DOI":"10.1101\/2024.03.28.587246","author":"H Mansour","year":"2024","unstructured":"Mansour H, Azrak R, Cook JJ et al (2024) An open resource: MR and light sheet microscopy stereotaxic atlas of the mouse brain. bioRxiv. https:\/\/doi.org\/10.1101\/2024.03.28.587246","journal-title":"bioRxiv"},{"issue":"3","key":"11134_CR33","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.cell.2020.12.025","volume":"184","author":"M Maor-Nof","year":"2021","unstructured":"Maor-Nof M, Shipony Z, Lopez-Gonzalez R et al (2021) p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR). Cell 184(3):689\u2013708","journal-title":"Cell"},{"issue":"11","key":"11134_CR34","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1002\/alz.12142","volume":"16","author":"A Marseglia","year":"2020","unstructured":"Marseglia A, Darin-Mattsson A, Kalpouzos G et al (2020) Can active life mitigate the impact of diabetes on dementia and brain aging? Alzheimers Dement 16(11):1534\u20131543","journal-title":"Alzheimers Dement"},{"key":"11134_CR35","doi-asserted-by":"publisher","first-page":"102141","DOI":"10.1016\/j.arr.2023.102141","volume":"93","author":"DSL Melo","year":"2024","unstructured":"Melo DSL, Trombetta-Lima M, Eggen B et al (2024) Cellular senescence in brain aging and neurodegeneration. Ageing Res Rev 93:102141","journal-title":"Ageing Res Rev"},{"key":"11134_CR36","doi-asserted-by":"publisher","first-page":"111445","DOI":"10.1016\/j.intimp.2023.111445","volume":"127","author":"J Meng","year":"2024","unstructured":"Meng J, Han L, Xu H et al (2024) TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance. Int Immunopharmacol 127:111445","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"11134_CR37","doi-asserted-by":"publisher","first-page":"e54514","DOI":"10.1371\/journal.pone.0054514","volume":"8","author":"R Mortuza","year":"2013","unstructured":"Mortuza R, Chen S, Feng B et al (2013) High glucose induced alteration of SIRTs in endothelial cells causes rapid aging in a p300 and FOXO regulated pathway. PLoS ONE 8(1):e54514","journal-title":"PLoS ONE"},{"key":"11134_CR38","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab136","author":"A Narasimhan","year":"2021","unstructured":"Narasimhan A, Flores RR, Robbins PD et al (2021) Role of cellular senescence in type II diabetes. Endocrinology. https:\/\/doi.org\/10.1210\/endocr\/bqab136","journal-title":"Endocrinology"},{"issue":"5","key":"11134_CR39","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nmeth.3337","volume":"12","author":"AM Newman","year":"2015","unstructured":"Newman AM, Liu CL, Green MR et al (2015) Robust enumeration of cell subsets from tissue expression profiles. Nat Methods 12(5):453\u2013457","journal-title":"Nat Methods"},{"key":"11134_CR40","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.exger.2016.02.013","volume":"86","author":"AK Palmer","year":"2016","unstructured":"Palmer AK, Kirkland JL (2016) Aging and adipose tissue: potential interventions for diabetes and regenerative medicine. Exp Gerontol 86:97\u2013105","journal-title":"Exp Gerontol"},{"issue":"10","key":"11134_CR41","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1007\/s00125-019-4934-x","volume":"62","author":"AK Palmer","year":"2019","unstructured":"Palmer AK, Gustafson B, Kirkland JL et al (2019) Cellular senescence: at the nexus between ageing and diabetes. Diabetologia 62(10):1835\u20131841","journal-title":"Diabetologia"},{"key":"11134_CR42","doi-asserted-by":"publisher","first-page":"101601","DOI":"10.1016\/j.molmet.2022.101601","volume":"66","author":"AK Palmer","year":"2022","unstructured":"Palmer AK, Tchkonia T, Kirkland JL (2022) Targeting cellular senescence in metabolic disease. Mol Metab 66:101601","journal-title":"Mol Metab"},{"issue":"4","key":"11134_CR43","doi-asserted-by":"publisher","first-page":"369","DOI":"10.2174\/1570161117666190715121939","volume":"18","author":"HT Phu","year":"2020","unstructured":"Phu HT, Thuan D, Nguyen T et al (2020) Herbal medicine for slowing aging and aging-associated conditions: efficacy. Mech Saf Curr Vasc Pharmacol 18(4):369\u2013393","journal-title":"Mech Saf Curr Vasc Pharmacol"},{"issue":"4","key":"11134_CR44","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1111\/nan.12476","volume":"44","author":"JJ Pruzin","year":"2018","unstructured":"Pruzin JJ, Nelson PT, Abner EL et al (2018) Review: relationship of type 2 diabetes to human brain pathology. Neuropathol Appl Neurobiol 44(4):347\u2013362","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"4","key":"11134_CR45","first-page":"96","volume":"30","author":"M Regulski","year":"2018","unstructured":"Regulski M (2018) Understanding diabetic induction of cellular senescence: a concise review. Wounds 30(4):96\u2013101","journal-title":"Wounds"},{"issue":"4","key":"11134_CR46","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.cellsig.2011.12.006","volume":"24","author":"A Salminen","year":"2012","unstructured":"Salminen A, Kauppinen A, Kaarniranta K (2012) Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal 24(4):835\u2013845","journal-title":"Cell Signal"},{"issue":"5","key":"11134_CR47","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.bbadis.2008.12.003","volume":"1792","author":"TM S\u00e1-Roriz","year":"2009","unstructured":"S\u00e1-Roriz TM, Rosset I, Camozzato AL, Santos AC, Chaves ML, Moriguti JC, Roriz-Cruz M (2009) (Pre)diabetes, brain aging, and cognition. Biochim Biophys Acta 1792(5):432\u2013443","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"11134_CR48","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1016\/j.immuni.2022.07.004","volume":"55","author":"A Silvin","year":"2022","unstructured":"Silvin A, Uderhardt S, Piot C et al (2022) Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration. Immunity 55(8):1448\u20131465","journal-title":"Immunity"},{"key":"11134_CR49","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27061904","author":"X Song","year":"2022","unstructured":"Song X, Zhu Z, Qian X et al (2022) Multi-omics characterization of type 2 diabetes mellitus-induced cognitive impairment in the db\/db mouse model. Molecules. https:\/\/doi.org\/10.3390\/molecules27061904","journal-title":"Molecules"},{"issue":"3","key":"11134_CR50","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1074\/mcp.M112.019141","volume":"12","author":"H Sun","year":"2013","unstructured":"Sun H, Zhang A, Yan G et al (2013) Metabolomic analysis of key regulatory metabolites in hepatitis C virus-infected tree shrews. Mol Cell Proteomics 12(3):710\u2013719","journal-title":"Mol Cell Proteomics"},{"issue":"D1","key":"11134_CR51","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","volume":"49","author":"D Szklarczyk","year":"2021","unstructured":"Szklarczyk D, Gable AL, Nastou KC et al (2021) The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets. Nucleic Acids Res 49(D1):D605\u2013D612","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"11134_CR52","doi-asserted-by":"publisher","first-page":"15752","DOI":"10.1038\/s41598-021-95344-5","volume":"11","author":"C Torres-Querol","year":"2021","unstructured":"Torres-Querol C, Torres P, Vidal N et al (2021) Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype. Sci Rep 11(1):15752","journal-title":"Sci Rep"},{"key":"11134_CR53","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042103","author":"R Tzoneva","year":"2024","unstructured":"Tzoneva R (2024) Special issue role of apoptosis and cellular senescence in cancer and aging. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms25042103","journal-title":"Int J Mol Sci"},{"issue":"7995","key":"11134_CR54","doi-asserted-by":"publisher","first-page":"E15","DOI":"10.1038\/s41586-023-07002-7","volume":"625","author":"S Victorelli","year":"2024","unstructured":"Victorelli S, Salmonowicz H, Chapman J et al (2024) Author correction: apoptotic stress causes mtDNA release during senescence and drives the SASP. Nature 625(7995):E15","journal-title":"Nature"},{"issue":"5","key":"11134_CR55","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.bbadis.2008.10.013","volume":"1792","author":"SA Wrighten","year":"2009","unstructured":"Wrighten SA, Piroli GG, Grillo CA et al (2009) A look inside the diabetic brain: Contributors to diabetes-induced brain aging. Biochim Biophys Acta 1792(5):444\u2013453","journal-title":"Biochim Biophys Acta"},{"issue":"19","key":"11134_CR56","doi-asserted-by":"publisher","first-page":"23133","DOI":"10.18632\/aging.203607","volume":"13","author":"CJ Xu","year":"2021","unstructured":"Xu CJ, Li MQ, Chen WG, Wang JL (2021) Short-term high-fat diet favors the appearances of apoptosis and gliosis by activation of ERK1\/2\/p38MAPK pathways in brain. Aging (Albany NY) 13(19):23133\u201323148","journal-title":"Aging (Albany NY)"},{"issue":"8","key":"11134_CR57","doi-asserted-by":"publisher","first-page":"3848","DOI":"10.1007\/s12035-021-02390-1","volume":"58","author":"T Xu","year":"2021","unstructured":"Xu T, Liu J, Li XR et al (2021b) The mTOR\/NF-kappaB pathway mediates neuroinflammation and synaptic plasticity in diabetic encephalopathy. Mol Neurobiol 58(8):3848\u20133862","journal-title":"Mol Neurobiol"},{"key":"11134_CR58","doi-asserted-by":"publisher","first-page":"100944","DOI":"10.1016\/j.arr.2019.100944","volume":"55","author":"M Xue","year":"2019","unstructured":"Xue M, Xu W, Ou YN et al (2019) Diabetes mellitus and risks of cognitive impairment and dementia: a systematic review and meta-analysis of 144 prospective studies. Ageing Res Rev 55:100944","journal-title":"Ageing Res Rev"},{"key":"11134_CR59","doi-asserted-by":"publisher","first-page":"1033128","DOI":"10.3389\/fnagi.2022.1033128","volume":"14","author":"Z Yan","year":"2022","unstructured":"Yan Z, Zong Y, Zhang C et al (2022) Exploring the role of Tibetan medicinal formula Qishiwei Zhenzhu Pills (Ranasampel) against diabetes mellitus-linked cognitive impairment of db\/db mice through serum pharmacochemistry and microarray data analysis. Front Aging Neurosci 14:1033128","journal-title":"Front Aging Neurosci"},{"key":"11134_CR60","doi-asserted-by":"publisher","DOI":"10.3390\/biom12020327","author":"L Zavileyskiy","year":"2022","unstructured":"Zavileyskiy L, Bunik V (2022) Regulation of p53 function by formation of non-nuclear heterologous protein complexes. Biomolecules. https:\/\/doi.org\/10.3390\/biom12020327","journal-title":"Biomolecules"},{"issue":"5","key":"11134_CR61","doi-asserted-by":"publisher","first-page":"781","DOI":"10.4093\/dmj.2021.0189","volume":"46","author":"T Zhang","year":"2022","unstructured":"Zhang T, Shaw M, Cherbuin N (2022a) Association between type 2 diabetes mellitus and brain atrophy: a meta-analysis. Diabetes Metab J 46(5):781\u2013802","journal-title":"Diabetes Metab J"},{"key":"11134_CR62","doi-asserted-by":"publisher","DOI":"10.1172\/JCI158450","author":"L Zhang","year":"2022","unstructured":"Zhang L, Pitcher LE, Yousefzadeh MJ et al (2022) Cellular senescence: a key therapeutic target in aging and diseases. J Clin Invest. https:\/\/doi.org\/10.1172\/JCI158450","journal-title":"J Clin Invest"},{"key":"11134_CR63","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.neuroscience.2023.02.011","volume":"515","author":"W Zhang","year":"2023","unstructured":"Zhang W, Chen S, Zhuang X (2023) Research progress on lipocalin-2 in diabetic encephalopathy. Neuroscience 515:74\u201382","journal-title":"Neuroscience"},{"issue":"4","key":"11134_CR64","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1007\/s00125-017-4541-7","volume":"61","author":"F Zheng","year":"2018","unstructured":"Zheng F, Yan L, Yang Z et al (2018) HbA(1c), diabetes and cognitive decline: the english longitudinal study of ageing. Diabetologia 61(4):839\u2013848","journal-title":"Diabetologia"},{"issue":"1","key":"11134_CR65","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Zhou B, Pache L et al (2019) Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun 10(1):1523","journal-title":"Nat Commun"},{"issue":"2","key":"11134_CR66","doi-asserted-by":"publisher","first-page":"e13543","DOI":"10.1111\/acel.13543","volume":"21","author":"XY Zhou","year":"2022","unstructured":"Zhou XY, Ying CJ, Hu B et al (2022) Receptor for advanced glycation end products aggravates cognitive deficits in type 2 diabetes through binding of C-terminal AAs 2\u20135 to mitogen-activated protein kinase kinase 3 (MKK3) and facilitation of MEKK3-MKK3-p38 module assembly. Aging Cell 21(2):e13543","journal-title":"Aging Cell"},{"issue":"1","key":"11134_CR67","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12993-021-00179-9","volume":"17","author":"A Zia","year":"2021","unstructured":"Zia A, Pourbagher-Shahri AM, Farkhondeh T et al (2021) Molecular and cellular pathways contributing to brain aging. Behav Brain Funct 17(1):6","journal-title":"Behav Brain Funct"},{"issue":"2","key":"11134_CR68","first-page":"759","volume":"19","author":"J Zou","year":"2019","unstructured":"Zou J, Lei T, Guo P et al (2019) Mechanisms shaping the role of ERK1\/2 in cellular senescence (Review). Mol Med Rep 19(2):759\u2013770","journal-title":"Mol Med Rep"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-025-11134-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-025-11134-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-025-11134-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:03:32Z","timestamp":1776434612000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10528-025-11134-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,21]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["11134"],"URL":"https:\/\/doi.org\/10.1007\/s10528-025-11134-y","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,21]]},"assertion":[{"value":"31 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All of the authors had no any personal, financial, commercial, or academic conflicts of interest separately.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The experimental protocol was approved by the Animal Ethics Committee of Beijing University of Chinese Medicine (BUCM-4\u20132022012105-1060).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The experimental protocol was approved by the Animal Ethics Committee of Beijing University of Chinese Medicine (BUCM-4\u20132022012105-1060).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}