{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:35:31Z","timestamp":1783726531921,"version":"3.55.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s10528-025-11173-5","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T02:32:14Z","timestamp":1753237934000},"page":"3580-3594","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Circ-Hipk3 in Adipose Derived Stem Cells Exosome Alleviates Myocardial Infarction Induced Myocardial Damage by Regulation miR-138-5p\/Sirt1 Axis Mediated Autophagy"],"prefix":"10.1007","volume":"64","author":[{"given":"Guoxun","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danpeng","family":"Nong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haien","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"11173_CR1","doi-asserted-by":"publisher","unstructured":"(2022) Circ_HIPK3 knockdown inhibits cell proliferation, migration and invasion of cholangiocarcinoma partly via mediating the miR-148a-3p\/ULK1 pathway [Retraction]. Cancer Manag Res 14:1713\u20131714. https:\/\/doi.org\/10.2147\/cmar.S374275","DOI":"10.2147\/cmar.S374275"},{"issue":"5","key":"11173_CR2","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12669","volume":"52","author":"S Chen","year":"2019","unstructured":"Chen S, Tang Y, Liu Y, Zhang P, Lv L, Zhang X, Jia L, Zhou Y (2019) Exosomes derived from miR-375-overexpressing human adipose mesenchymal stem cells promote bone regeneration. Cell Prolif 52(5):e12669. https:\/\/doi.org\/10.1111\/cpr.12669","journal-title":"Cell Prolif"},{"key":"11173_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2019.105564","volume":"114","author":"S Deng","year":"2019","unstructured":"Deng S, Zhou X, Ge Z, Song Y, Wang H, Liu X, Zhang D (2019) Exosomes from adipose-derived mesenchymal stem cells ameliorate cardiac damage after myocardial infarction by activating S1P\/SK1\/S1PR1 signaling and promoting macrophage M2 polarization. Int J Biochem Cell Biol 114:105564. https:\/\/doi.org\/10.1016\/j.biocel.2019.105564","journal-title":"Int J Biochem Cell Biol"},{"key":"11173_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2023.101862","volume":"80","author":"M Fan","year":"2023","unstructured":"Fan M, Liang T, Xie F, Ma P, Li J (2023) Exosomal circ_HIPK3 reduces apoptosis in H2O2-induced AC16 cardiomyocytes through miR-33a-5p\/IRS1 axis. Transpl Immunol 80:101862. https:\/\/doi.org\/10.1016\/j.trim.2023.101862","journal-title":"Transpl Immunol"},{"key":"11173_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12102469","author":"Y Feng","year":"2022","unstructured":"Feng Y, Yang Z, Lv B, Xu X (2022) The diagnostic and therapeutic role of circular RNA HIPK3 in human diseases. Diagnostics (Basel). https:\/\/doi.org\/10.3390\/diagnostics12102469","journal-title":"Diagnostics (Basel)"},{"key":"11173_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051157","author":"DH Ha","year":"2020","unstructured":"Ha DH, Kim HK, Lee J, Kwon HH, Park GH, Yang SH, Jung JY, Choi H, Lee JH, Sung S, Yi YW, Cho BS (2020) Mesenchymal stem\/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration. Cells. https:\/\/doi.org\/10.3390\/cells9051157","journal-title":"Cells"},{"issue":"2","key":"11173_CR7","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s10616-018-0188-6","volume":"70","author":"H Jiang","year":"2018","unstructured":"Jiang H, Wang H, Liu T, Yang Z, Zhang R, Han H (2018) Co-cultured the MSCs and cardiomyocytes can promote the growth of cardiomyocytes. Cytotechnology 70(2):793\u2013806. https:\/\/doi.org\/10.1007\/s10616-018-0188-6","journal-title":"Cytotechnology"},{"issue":"1","key":"11173_CR8","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s13287-019-1177-1","volume":"10","author":"J Jin","year":"2019","unstructured":"Jin J, Shi Y, Gong J, Zhao L, Li Y, He Q, Huang H (2019) Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte. Stem Cell Res Ther 10(1):95. https:\/\/doi.org\/10.1186\/s13287-019-1177-1","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"11173_CR9","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1186\/s13071-020-04237-5","volume":"13","author":"SY Joo","year":"2020","unstructured":"Joo SY, Aung JM, Shin M, Moon EK, Kong HH, Goo YK, Chung DI, Hong Y (2020) The role of the Acanthamoeba castellanii Sir2-like protein in the growth and encystation of Acanthamoeba. Parasit Vectors 13(1):368. https:\/\/doi.org\/10.1186\/s13071-020-04237-5","journal-title":"Parasit Vectors"},{"key":"11173_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.569150","volume":"8","author":"TC Lai","year":"2020","unstructured":"Lai TC, Lee TL, Chang YC, Chen YC, Lin SR, Lin SW, Pu CM, Tsai JS, Chen YL (2020) MicroRNA-221\/222 Mediates ADSC-exosome-induced cardioprotection against ischemia\/reperfusion by targeting PUMA and ETS-1. Front Cell Dev Biol 8:569150. https:\/\/doi.org\/10.3389\/fcell.2020.569150","journal-title":"Front Cell Dev Biol"},{"key":"11173_CR11","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.bbrc.2021.03.070","volume":"553","author":"Y Liu","year":"2021","unstructured":"Liu Y, Ao S, Zhang H, Zhang Y, Wang Y, Yang X, Leng H (2021) Circ_HIPK3 alleviates CoCl(2)-induced apoptotic injury in neuronal cells by depending on the regulation of the miR-222-3p\/DUSP19 axis. Biochem Biophys Res Commun 553:126\u2013133. https:\/\/doi.org\/10.1016\/j.bbrc.2021.03.070","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"11173_CR12","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.3892\/ijmm.2019.4125","volume":"43","author":"G Luo","year":"2019","unstructured":"Luo G, Jian Z, Zhu Y, Zhu Y, Chen B, Ma R, Tang F, Xiao Y (2019) Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress. Int J Mol Med 43(5):2033\u20132043. https:\/\/doi.org\/10.3892\/ijmm.2019.4125","journal-title":"Int J Mol Med"},{"issue":"4","key":"11173_CR13","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/tox.22708","volume":"34","author":"J Ma","year":"2019","unstructured":"Ma J, Zhang Y, Ji H, Chen L, Chen T, Guo C, Zhang S, Jia J, Niu P (2019) Overexpression of miR-138-5p suppresses MnCl(2) -induced autophagy by targeting SIRT1 in SH-SY5Y cells. Environ Toxicol 34(4):539\u2013547. https:\/\/doi.org\/10.1002\/tox.22708","journal-title":"Environ Toxicol"},{"issue":"6","key":"11173_CR14","doi-asserted-by":"publisher","first-page":"5231","DOI":"10.3892\/mmr.2020.11636","volume":"22","author":"S Ning","year":"2020","unstructured":"Ning S, Li Z, Ji Z, Fan D, Wang K, Wang Q, Hua L, Zhang J, Meng X, Yuan Y (2020) MicroRNA-494 suppresses hypoxia\/reoxygenation-induced cardiomyocyte apoptosis and autophagy via the PI3K\/AKT\/mTOR signaling pathway by targeting SIRT1. Mol Med Rep 22(6):5231\u20135242. https:\/\/doi.org\/10.3892\/mmr.2020.11636","journal-title":"Mol Med Rep"},{"issue":"11","key":"11173_CR15","doi-asserted-by":"publisher","first-page":"3794","DOI":"10.1080\/15548627.2021.1938913","volume":"17","author":"I Rabinovich-Nikitin","year":"2021","unstructured":"Rabinovich-Nikitin I, Rasouli M, Reitz CJ, Posen I, Margulets V, Dhingra R, Khatua TN, Thliveris JA, Martino TA, Kirshenbaum LA (2021) Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress. Autophagy 17(11):3794\u20133812. https:\/\/doi.org\/10.1080\/15548627.2021.1938913","journal-title":"Autophagy"},{"key":"11173_CR16","doi-asserted-by":"publisher","DOI":"10.12659\/msm.928480","volume":"27","author":"X Wang","year":"2021","unstructured":"Wang X, Xu Y, Li L, Lu W (2021) Thrombin aggravates hypoxia\/reoxygenation injury of cardiomyocytes by activating an autophagy pathway-mediated by SIRT1. Med Sci Monit 27:e928480. https:\/\/doi.org\/10.12659\/msm.928480","journal-title":"Med Sci Monit"},{"issue":"1","key":"11173_CR17","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13062-023-00361-1","volume":"18","author":"T Wang","year":"2023","unstructured":"Wang T, Li T, Niu X, Hu L, Cheng J, Guo D, Ren H, Zhao R, Ji Z, Liu P, Li Y, Guo Y (2023) ADSC-derived exosomes attenuate myocardial infarction injury by promoting miR-205-mediated cardiac angiogenesis. Biol Direct 18(1):6. https:\/\/doi.org\/10.1186\/s13062-023-00361-1","journal-title":"Biol Direct"},{"key":"11173_CR18","doi-asserted-by":"publisher","first-page":"551","DOI":"10.3389\/fphar.2019.00551","volume":"10","author":"D Wu","year":"2019","unstructured":"Wu D, Zhang K, Hu P (2019) The role of autophagy in acute myocardial infarction. Front Pharmacol 10:551. https:\/\/doi.org\/10.3389\/fphar.2019.00551","journal-title":"Front Pharmacol"},{"issue":"7","key":"11173_CR19","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1177\/0963689719843806","volume":"28","author":"Y Xiao","year":"2019","unstructured":"Xiao Y, Zhao J, Tuazon JP, Borlongan CV, Yu G (2019) MicroRNA-133a and Myocardial Infarction. Cell Transplant 28(7):831\u2013838. https:\/\/doi.org\/10.1177\/0963689719843806","journal-title":"Cell Transplant"},{"key":"11173_CR20","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1016\/j.ijbiomac.2019.11.119","volume":"155","author":"R Yao","year":"2020","unstructured":"Yao R, Yao Y, Li C, Li X, Ni W, Quan R, Liu L, Li H, Xu Y, Zhang M, Ullah Y, Hu S (2020) Circ-HIPK3 plays an active role in regulating myoblast differentiation. Int J Biol Macromol 155:1432\u20131439. https:\/\/doi.org\/10.1016\/j.ijbiomac.2019.11.119","journal-title":"Int J Biol Macromol"},{"issue":"2","key":"11173_CR21","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s11010-022-04510-4","volume":"478","author":"Z Zhong","year":"2023","unstructured":"Zhong Z, Luo XY, Xiang P, Ji HH, Wu XD, Chong AG, Hu XY, Cao XL (2023) MRTF-A alleviates myocardial ischemia reperfusion injury by inhibiting the inflammatory response and inducing autophagy. Mol Cell Biochem 478(2):343\u2013359. https:\/\/doi.org\/10.1007\/s11010-022-04510-4","journal-title":"Mol Cell Biochem"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-025-11173-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-025-11173-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-025-11173-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T09:08:20Z","timestamp":1779181700000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10528-025-11173-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["11173"],"URL":"https:\/\/doi.org\/10.1007\/s10528-025-11173-5","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,23]]},"assertion":[{"value":"24 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"This study was approved by the ethics committee of Institutional Animal Care and Use Committee of Guangxi International Zhuang Medicine Hospital (No. DW20231023-233).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"All procedures performed in studies were approved by the Animal Protection and Ethics Committee of our hospital and was reported in accordance with ARRIVE guidelines.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}