{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:17:55Z","timestamp":1780373875140,"version":"3.54.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s10528-025-11186-0","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T09:21:50Z","timestamp":1755768110000},"page":"3960-3985","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Extracellular Vesicle-Associated MicroRNA-25-3p Derived from Pancreatic Cancer Cells Promotes Hepatic Stellate Cell Activation and Enhances Cancer Progression"],"prefix":"10.1007","volume":"64","author":[{"given":"Xuejiao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8183-9497","authenticated-orcid":false,"given":"Weiyan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"issue":"3","key":"11186_CR1","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1055\/s-2008-1033797","volume":"194","author":"H Bachmann","year":"1982","unstructured":"Bachmann H (1982) Hypertension, a frequent complication in children and adolescents with reflux nephropathy. Klin Padiatr 194(3):152\u2013153","journal-title":"Klin Padiatr"},{"issue":"4","key":"11186_CR2","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1039\/D4TB01090F","volume":"13","author":"R Chaudhari","year":"2025","unstructured":"Chaudhari R, Patel V, Malvi B, Misra SK, Kumar A (2025) Maximising efficacy in HER2-positive breast cancer: immunoliposomal co-delivery of miR155 inhibitor and paclitaxel for targeted therapy. J Mater Chem B 13(4):1350\u20131362","journal-title":"J Mater Chem B"},{"issue":"10","key":"11186_CR3","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1038\/cr.2008.282","volume":"18","author":"X Chen","year":"2008","unstructured":"Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K, Guo J, Zhang Y, Chen J, Guo X et al (2008) Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18(10):997\u20131006","journal-title":"Cell Res"},{"issue":"8","key":"11186_CR4","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1245\/s10434-011-2181-6","volume":"19","author":"Y Doi","year":"2012","unstructured":"Doi Y, Yashiro M, Yamada N, Amano R, Noda S, Hirakawa K (2012) VEGF-A\/VEGFR-2 signaling plays an important role for the motility of pancreas cancer cells. Ann Surg Oncol 19(8):2733\u20132743","journal-title":"Ann Surg Oncol"},{"key":"11186_CR5","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.ejca.2018.07.005","volume":"103","author":"J Ferlay","year":"2018","unstructured":"Ferlay J, Colombet M, Soerjomataram I, Dyba T, Randi G, Bettio M, Gavin A, Visser O, Bray F (2018) Cancer incidence and mortality patterns in Europe: estimates for 40 countries and 25 major cancers in 2018. Eur J Cancer (Oxford, England: 1990) 103:356\u2013387","journal-title":"Eur J Cancer (Oxford, England: 1990)"},{"key":"11186_CR6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.gene.2017.02.025","volume":"611","author":"AM Ghaleb","year":"2017","unstructured":"Ghaleb AM, Yang VW (2017) Kr\u00fcppel-like factor 4 (KLF4): what we currently know. Gene 611:27\u201337","journal-title":"Gene"},{"issue":"1","key":"11186_CR7","doi-asserted-by":"publisher","first-page":"296","DOI":"10.2119\/molmed.2014.00172","volume":"21","author":"C Gras","year":"2015","unstructured":"Gras C, Ratuszny D, Hadamitzky C, Zhang H, Blasczyk R, Figueiredo C (2015) miR-145 contributes to hypertrophic scarring of the skin by inducing myofibroblast activity. Mol Med (Cambridge, Mass) 21(1):296\u2013304","journal-title":"Mol Med (Cambridge, Mass)"},{"issue":"1","key":"11186_CR8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12943-019-0980-8","volume":"18","author":"L Han","year":"2019","unstructured":"Han L, Lam EW, Sun Y (2019) Extracellular vesicles in the tumor microenvironment: old stories, but new tales. Mol Cancer 18(1):59","journal-title":"Mol Cancer"},{"issue":"18","key":"11186_CR9","doi-asserted-by":"publisher","first-page":"4557","DOI":"10.1158\/0008-5472.CAN-18-3962","volume":"79","author":"DC Hinshaw","year":"2019","unstructured":"Hinshaw DC, Shevde LA (2019) The tumor microenvironment innately modulates cancer progression. Cancer Res 79(18):4557\u20134566","journal-title":"Cancer Res"},{"issue":"9","key":"11186_CR10","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41571-020-0363-5","volume":"17","author":"WJ Ho","year":"2020","unstructured":"Ho WJ, Jaffee EM, Zheng L (2020) The tumour microenvironment in pancreatic cancer - clinical challenges and opportunities. Nat Rev Clin Oncol 17(9):527\u2013540","journal-title":"Nat Rev Clin Oncol"},{"issue":"9","key":"11186_CR11","doi-asserted-by":"publisher","first-page":"e12509","DOI":"10.1002\/jev2.12509","volume":"13","author":"S Kewitz-Hempel","year":"2024","unstructured":"Kewitz-Hempel S, Windisch N, Hause G, M\u00fcller L, Sunderk\u00f6tter C, Gerloff D (2024) Extracellular vesicles derived from melanoma cells induce carcinoma-associated fibroblasts via miR-92b-3p mediated downregulation of PTEN. J Extracell Vesicles 13(9):e12509","journal-title":"J Extracell Vesicles"},{"issue":"3","key":"11186_CR12","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1007\/s12029-022-00877-1","volume":"54","author":"IA Khan","year":"2023","unstructured":"Khan IA, Saraya A (2023) Circulating MicroRNAs as noninvasive diagnostic and prognostic biomarkers in pancreatic cancer: a review. J Gastrointest Cancer 54(3):720\u2013730","journal-title":"J Gastrointest Cancer"},{"issue":"10","key":"11186_CR13","doi-asserted-by":"publisher","first-page":"3777","DOI":"10.7150\/thno.97755","volume":"14","author":"EH Kim","year":"2024","unstructured":"Kim EH, Choi J, Jang H, Kim Y, Lee JW, Ryu Y, Choi J, Choi Y, Chi SG, Kwon IC et al (2024) Targeted delivery of anti-miRNA21 sensitizes PD-L1(high) tumor to immunotherapy by promoting immunogenic cell death. Theranostics 14(10):3777\u20133792","journal-title":"Theranostics"},{"key":"11186_CR14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.semcancer.2024.02.001","volume":"99","author":"Y Li","year":"2024","unstructured":"Li Y, Sui S, Goel A (2024) Extracellular vesicles associated microRNAs: their biology and clinical significance as biomarkers in gastrointestinal cancers. Semin Cancer Biol 99:5\u201323","journal-title":"Semin Cancer Biol"},{"key":"11186_CR15","doi-asserted-by":"publisher","first-page":"e2405872","DOI":"10.1002\/smll.202405872","volume":"21","author":"Z Liu","year":"2024","unstructured":"Liu Z, Pang B, Wang Y, Zheng J, Li Y, Jiang J (2024) Advances of new extracellular vesicle isolation and detection technologies in cancer diagnosis. Small 21:e2405872","journal-title":"Small"},{"issue":"1","key":"11186_CR16","doi-asserted-by":"publisher","first-page":"691","DOI":"10.3892\/mmr.2014.2689","volume":"11","author":"Y Lu","year":"2015","unstructured":"Lu Y, Lin N, Chen Z, Xu R (2015) Hypoxia-induced secretion of platelet-derived growth factor-BB by hepatocellular carcinoma cells increases activated hepatic stellate cell proliferation, migration and expression of vascular endothelial growth factor-A. Mol Med Rep 11(1):691\u2013697","journal-title":"Mol Med Rep"},{"issue":"13","key":"11186_CR17","doi-asserted-by":"publisher","first-page":"e2308688","DOI":"10.1002\/smll.202308688","volume":"20","author":"C Lu","year":"2024","unstructured":"Lu C, Xie L, Qiu S, Jiang T, Wang L, Chen Z, Xia Y, Lv J, Li Y, Li B et al (2024) Small extracellular vesicles derived from helicobacter pylori-infected gastric cancer cells induce lymphangiogenesis and lymphatic remodeling via transfer of miR-1246. Small 20(13):e2308688","journal-title":"Small"},{"issue":"10242","key":"11186_CR18","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1016\/S0140-6736(20)30974-0","volume":"395","author":"JD Mizrahi","year":"2020","unstructured":"Mizrahi JD, Surana R, Valle JW, Shroff RT (2020) Pancreatic cancer. Lancet (London, England) 395(10242):2008\u20132020","journal-title":"Lancet (London, England)"},{"issue":"45","key":"11186_CR19","doi-asserted-by":"publisher","first-page":"30943","DOI":"10.1021\/acsnano.3c12967","volume":"18","author":"Z Peng","year":"2024","unstructured":"Peng Z, Zhao T, Gao P, Zhang G, Wu X, Tian H, Qu M, Tan X, Zhang Y, Zhao X et al (2024) Tumor-derived extracellular vesicles enable tumor tropism chemo-genetherapy for local immune activation in triple-negative breast cancer. ACS Nano 18(45):30943\u201330956","journal-title":"ACS Nano"},{"issue":"7","key":"11186_CR20","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/S2468-1253(19)30416-9","volume":"5","author":"SP Pereira","year":"2020","unstructured":"Pereira SP, Oldfield L, Ney A, Hart PA, Keane MG, Pandol SJ, Li D, Greenhalf W, Jeon CY, Koay EJ et al (2020) Early detection of pancreatic cancer. Lancet Gastroenterol Hepatol 5(7):698\u2013710","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"11186_CR21","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.addr.2014.10.020","volume":"81","author":"S Rachagani","year":"2015","unstructured":"Rachagani S, Macha MA, Heimann N, Seshacharyulu P, Haridas D, Chugh S, Batra SK (2015) Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer. Adv Drug Deliv Rev 81:16\u201333","journal-title":"Adv Drug Deliv Rev"},{"issue":"6","key":"11186_CR22","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.1158\/0008-5472.CAN-06-3362","volume":"67","author":"V Ramachandran","year":"2007","unstructured":"Ramachandran V, Arumugam T, Hwang RF, Greenson JK, Simeone DM, Logsdon CD (2007) Adrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the adrenomedullin receptor. ADMR Cancer Res 67(6):2666\u20132675","journal-title":"ADMR Cancer Res"},{"issue":"6","key":"11186_CR23","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/hepr.12872","volume":"47","author":"Y Saito","year":"2017","unstructured":"Saito Y, Morine Y, Shimada M (2017) Mechanism of impairment on liver regeneration in elderly patients: role of hepatic stellate cell function. Hepatol Res 47(6):505\u2013513","journal-title":"Hepatol Res"},{"issue":"3","key":"11186_CR24","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nrclinonc.2014.5","volume":"11","author":"H Schwarzenbach","year":"2014","unstructured":"Schwarzenbach H, Nishida N, Calin GA, Pantel K (2014) Clinical relevance of circulating cell-free microRNAs in cancer. Nat Rev Clin Oncol 11(3):145\u2013156","journal-title":"Nat Rev Clin Oncol"},{"issue":"4","key":"11186_CR25","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","volume":"126","author":"K Takahashi","year":"2006","unstructured":"Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126(4):663\u2013676","journal-title":"Cell"},{"issue":"1","key":"11186_CR26","first-page":"10","volume":"1","author":"X Tian","year":"2023","unstructured":"Tian X, Liu G, Yang Y (2023) Status and prospect of comprehensive treatment for pancreatic cancer with oligometastatic disease. Transl Surg Oncol 1(1):10\u201314","journal-title":"Transl Surg Oncol"},{"issue":"2","key":"11186_CR27","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.jhep.2009.03.016","volume":"51","author":"YW Tien","year":"2009","unstructured":"Tien YW, Wu YM, Lin WC, Lee HS, Lee PH (2009) Pancreatic carcinoma cells stimulate proliferation and matrix synthesis of hepatic stellate cells. J Hepatol 51(2):307\u2013314","journal-title":"J Hepatol"},{"issue":"1","key":"11186_CR28","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/s41580-018-0059-1","volume":"20","author":"T Treiber","year":"2019","unstructured":"Treiber T, Treiber N, Meister G (2019) Regulation of microRNA biogenesis and its crosstalk with other cellular pathways. Nat Rev Mol Cell Biol 20(1):5\u201320","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"11186_CR29","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1002\/hep.31848","volume":"74","author":"SS Wang","year":"2021","unstructured":"Wang SS, Tang XT, Lin M, Yuan J, Peng YJ, Yin X, Shang G, Ge G, Ren Z, Zhou BO (2021a) Perivenous stellate cells are the main source of myofibroblasts and cancer-associated fibroblasts formed after chronic liver injuries. Hepatology 74(3):1578\u20131594","journal-title":"Hepatology"},{"issue":"2","key":"11186_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/ijo.2021.5244","volume":"59","author":"J Wang","year":"2021","unstructured":"Wang J, Li T, Wang B (2021b) Exosomal transfer of miR-25-3p promotes the proliferation and temozolomide resistance of glioblastoma cells by targeting FBXW7. Int J Oncol 59(2):1\u201315","journal-title":"Int J Oncol"},{"issue":"1","key":"11186_CR31","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/s41392-024-01937-7","volume":"9","author":"Y Wang","year":"2024","unstructured":"Wang Y, Jia J, Wang F, Fang Y, Yang Y, Zhou Q, Yuan W, Gu X, Hu J, Yang S (2024a) Pre-metastatic niche: formation, characteristics and therapeutic implication. Signal Transduct Target Ther 9(1):236","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"11186_CR32","doi-asserted-by":"publisher","first-page":"111","DOI":"10.32604\/biocell.2023.046903","volume":"48","author":"D Wang","year":"2024","unstructured":"Wang D, Shi Y, Wang Z, Zhang J, Wang L, Ma H, Shi S, Lian X, Huang H, Wang X et al (2024b) Meiotic nuclear divisions 1 suppresses the proliferation and invasion of pancreatic cancer cells via regulating H2A.X variant histone. Biocell 48(1):111\u2013122","journal-title":"Biocell"},{"issue":"9","key":"11186_CR33","doi-asserted-by":"publisher","first-page":"9351","DOI":"10.1021\/acsnano.5c00674","volume":"19","author":"D Wang","year":"2025","unstructured":"Wang D, Wang Y, Zhang S, Yang X, Yang Y, Han T, Luo Y, Shui C, Yang M, Lin Y et al (2025) Tetrahedral-DNA-nanostructure-modified engineered extracellular vesicles enhance oral squamous cell carcinomas therapy by targeting GPX4. ACS Nano 19(9):9351\u20139366","journal-title":"ACS Nano"},{"issue":"2","key":"11186_CR34","doi-asserted-by":"publisher","first-page":"e12404","DOI":"10.1002\/jev2.12404","volume":"13","author":"JA Welsh","year":"2024","unstructured":"Welsh JA, Goberdhan DCI, O\u2019Driscoll L, Buzas EI, Blenkiron C, Bussolati B, Cai H, Di Vizio D, Driedonks TAP, Erdbr\u00fcgger U et al (2024) Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches. J Extracell Vesicles 13(2):e12404","journal-title":"J Extracell Vesicles"},{"key":"11186_CR35","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.semcancer.2021.05.011","volume":"74","author":"J Weng","year":"2021","unstructured":"Weng J, Xiang X, Ding L, Wong AL, Zeng Q, Sethi G, Wang L, Lee SC, Goh BC (2021) Extracellular vesicles, the cornerstone of next-generation cancer diagnosis? Semin Cancer Biol 74:105\u2013120","journal-title":"Semin Cancer Biol"},{"issue":"11","key":"11186_CR36","doi-asserted-by":"publisher","first-page":"3006","DOI":"10.1016\/j.celrep.2018.11.065","volume":"25","author":"X Xiong","year":"2018","unstructured":"Xiong X, Schober M, Tassone E, Khodadadi-Jamayran A, Sastre-Perona A, Zhou H, Tsirigos A, Shen S, Chang M, Melamed J et al (2018) KLF4, a gene regulating prostate stem cell homeostasis, is a barrier to malignant progression and predictor of good prognosis in prostate cancer. Cell Rep 25(11):3006-3020.e3007","journal-title":"Cell Rep"},{"issue":"12","key":"11186_CR37","doi-asserted-by":"publisher","first-page":"942","DOI":"10.20892\/j.issn.2095-3941.2023.0483","volume":"20","author":"Y Xu","year":"2024","unstructured":"Xu Y, Lv Y, Zhu Z, Chen Y, Zhou P, Ye L, Tang W, Xu J (2024) Precision medicine in the treatment of colorectal cancer with liver metastases. Cancer Biol Med 20(12):942\u2013946","journal-title":"Cancer Biol Med"},{"issue":"1","key":"11186_CR38","doi-asserted-by":"publisher","first-page":"5395","DOI":"10.1038\/s41467-018-07810-w","volume":"9","author":"Z Zeng","year":"2018","unstructured":"Zeng Z, Li Y, Pan Y, Lan X, Song F, Sun J, Zhou K, Liu X, Ren X, Wang F et al (2018) Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis. Nat Commun 9(1):5395","journal-title":"Nat Commun"},{"issue":"1","key":"11186_CR39","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1038\/s41467-019-09712-x","volume":"10","author":"J Zhang","year":"2019","unstructured":"Zhang J, Bai R, Li M, Ye H, Wu C, Wang C, Li S, Tan L, Mai D, Li G et al (2019a) Excessive miR-25-3p maturation via N(6)-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression. Nat Commun 10(1):1858","journal-title":"Nat Commun"},{"issue":"1","key":"11186_CR40","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s10120-018-0833-y","volume":"22","author":"J Zhang","year":"2019","unstructured":"Zhang J, Zhu Z, Wu H, Yu Z, Rong Z, Luo Z, Xu Y, Huang K, Qiu Z, Huang C (2019b) PODXL, negatively regulated by KLF4, promotes the EMT and metastasis and serves as a novel prognostic indicator of gastric cancer. Gastric Cancer 22(1):48\u201359","journal-title":"Gastric Cancer"},{"issue":"3","key":"11186_CR41","first-page":"62","volume":"1","author":"X Zhang","year":"2024","unstructured":"Zhang X, Chen Y, Tian X, Ma Y, Liu W (2024) Diagnosis and treatment of pancreatic metastases from renal cancer: current status. Transl Surg Oncol 1(3):62\u201371","journal-title":"Transl Surg Oncol"},{"issue":"1","key":"11186_CR42","doi-asserted-by":"publisher","first-page":"e12186","DOI":"10.1002\/jev2.12186","volume":"11","author":"S Zhao","year":"2022","unstructured":"Zhao S, Mi Y, Zheng B, Wei P, Gu Y, Zhang Z, Xu Y, Cai S, Li X, Li D (2022) Highly-metastatic colorectal cancer cell released miR-181a-5p-rich extracellular vesicles promote liver metastasis by activating hepatic stellate cells and remodelling the tumour microenvironment. J Extracell Vesicles 11(1):e12186","journal-title":"J Extracell Vesicles"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-025-11186-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-025-11186-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-025-11186-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:03:02Z","timestamp":1779184982000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10528-025-11186-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["11186"],"URL":"https:\/\/doi.org\/10.1007\/s10528-025-11186-0","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,21]]},"assertion":[{"value":"24 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethical approval for this study was obtained from the Ethics Committee of Ruijin Hospital [Approval No. (2019) Lin Lun Shen (158)], with Dr. Wei-Yan Yao as the principal investigator. Animal experiments were approved by the Animal Ethics and Welfare Committee of Nanjing University (Approval No. IACUC-2009006).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Obtained.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}}]}}