{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:02:02Z","timestamp":1784624522612,"version":"3.55.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"crossref","award":["FRGS\/1\/2019\/SKK10\/UM\/02\/2"],"award-info":[{"award-number":["FRGS\/1\/2019\/SKK10\/UM\/02\/2"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s10528-025-11279-w","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T02:58:17Z","timestamp":1765162697000},"page":"5602-5631","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Annexin-A1 Regulates Apoptosis-Autophagy Switch in a 5-FU-Resistant Colorectal Cancer Stem-Like Model Through the PI3K\/AKT\/mTOR Axis"],"prefix":"10.1007","volume":"64","author":[{"given":"Thanusha","family":"Ganesan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamil Selvee","family":"Ramasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Abdullah","family":"Alshawsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajantha","family":"Sinniah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"11279_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12092111","author":"SK Acharya","year":"2024","unstructured":"Acharya SK et al (2024) Cancer stem cells in oral squamous cell carcinoma: a narrative review on experimental characteristics and methodological challenges. Biomedicines. https:\/\/doi.org\/10.3390\/biomedicines12092111","journal-title":"Biomedicines"},{"key":"11279_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24010644","author":"OS Al-Odat","year":"2022","unstructured":"Al-Odat OS et al (2022) Autophagy and apoptosis: current challenges of treatment and drug resistance in multiple myeloma. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms24010644","journal-title":"Int J Mol Sci"},{"issue":"10","key":"11279_CR3","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.3748\/wjg.v10.i10.1466","volume":"10","author":"XF Bai","year":"2004","unstructured":"Bai XF et al (2004) Overexpression of annexin 1 in pancreatic cancer and its clinical significance. World J Gastroenterol 10(10):1466\u20131470","journal-title":"World J Gastroenterol"},{"key":"11279_CR4","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2741\/4264","volume":"19","author":"DV Brown","year":"2014","unstructured":"Brown DV, Mantamadiotis T (2014) Insights into the next generation of cancer stem cell research. Front Biosci (Landmark Ed) 19:1015\u20131027","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"7","key":"11279_CR5","doi-asserted-by":"crossref","first-page":"12036","DOI":"10.1021\/acsomega.9b01142","volume":"4","author":"L Cai","year":"2019","unstructured":"Cai L et al (2019) Comparison of cytotoxicity evaluation of anticancer drugs between real-time cell analysis and CCK-8 method. ACS Omega 4(7):12036\u201312042","journal-title":"ACS Omega"},{"key":"11279_CR6","doi-asserted-by":"crossref","first-page":"1506426","DOI":"10.3389\/fimmu.2024.1506426","volume":"15","author":"Z Cao","year":"2024","unstructured":"Cao Z et al (2024) Beclin-1: a therapeutic target at the intersection of autophagy, immunotherapy, and cancer treatment. Front Immunol 15:1506426","journal-title":"Front Immunol"},{"key":"11279_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26154683","author":"GR Chang","year":"2021","unstructured":"Chang GR et al (2021) Anti-cancer effects of Zotarolimus combined with 5-fluorouracil treatment in HCT-116 colorectal cancer-bearing BALB\/c nude mice. Molecules. https:\/\/doi.org\/10.3390\/molecules26154683","journal-title":"Molecules"},{"issue":"9","key":"11279_CR8","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1038\/leu.2010.143","volume":"24","author":"Y Chen","year":"2010","unstructured":"Chen Y et al (2010) Critical molecular pathways in cancer stem cells of chronic myeloid leukemia. Leukemia 24(9):1545\u20131554","journal-title":"Leukemia"},{"issue":"6","key":"11279_CR9","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/aps.2013.27","volume":"34","author":"K Chen","year":"2013","unstructured":"Chen K, Huang YH, Chen JL (2013) Understanding and targeting cancer stem cells: therapeutic implications and challenges. Acta Pharmacol Sin 34(6):732\u2013740","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"11279_CR10","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41392-024-01851-y","volume":"9","author":"X Chu","year":"2024","unstructured":"Chu X et al (2024) Cancer stem cells: advances in knowledge and implications for cancer therapy. Signal Transduct Target Ther 9(1):170","journal-title":"Signal Transduct Target Ther"},{"key":"11279_CR11","doi-asserted-by":"crossref","first-page":"113904","DOI":"10.1016\/j.ab.2020.113904","volume":"608","author":"J Cort\u00e9s-R\u00edos","year":"2020","unstructured":"Cort\u00e9s-R\u00edos J et al (2020) Protein quantification by bicinchoninic acid (BCA) assay follows complex kinetics and can be performed at short incubation times. Anal Biochem 608:113904","journal-title":"Anal Biochem"},{"issue":"1","key":"11279_CR12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.cellsig.2013.09.020","volume":"26","author":"CW D'Acunto","year":"2014","unstructured":"D\u2019Acunto CW et al (2014) The complex understanding of Annexin A1 phosphorylation. Cell Signal 26(1):173\u2013178","journal-title":"Cell Signal"},{"issue":"9\u201310","key":"11279_CR13","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1007\/s10495-021-01687-9","volume":"26","author":"S Das","year":"2021","unstructured":"Das S et al (2021) Mechanism of interaction between autophagy and apoptosis in cancer. Apoptosis 26(9\u201310):512\u2013533","journal-title":"Apoptosis"},{"issue":"2","key":"11279_CR14","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/sj.bjc.6604128","volume":"98","author":"R Duncan","year":"2008","unstructured":"Duncan R et al (2008) Characterisation and protein expression profiling of annexins in colorectal cancer. Br J Cancer 98(2):426\u2013433","journal-title":"Br J Cancer"},{"issue":"1","key":"11279_CR15","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/biof.1708","volume":"47","author":"RK Dutta","year":"2021","unstructured":"Dutta RK et al (2021) Catalase deficiency induces reactive oxygen species mediated pexophagy and cell death in the liver during prolonged fasting. BioFactors 47(1):112\u2013125","journal-title":"BioFactors"},{"issue":"4","key":"11279_CR16","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","volume":"35","author":"S Elmore","year":"2007","unstructured":"Elmore S (2007) Apoptosis: a review of programmed cell death. Toxicol Pathol 35(4):495\u2013516","journal-title":"Toxicol Pathol"},{"key":"11279_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17030382","author":"M El-Tanani","year":"2025","unstructured":"El-Tanani M et al (2025) Deciphering the role of cancer stem cells: drivers of tumor evolution, therapeutic resistance, and precision medicine strategies. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers17030382","journal-title":"Cancers (Basel)"},{"issue":"2","key":"11279_CR18","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1021\/acs.chemrestox.3c00339","volume":"37","author":"J Fan","year":"2024","unstructured":"Fan J et al (2024) Cell via cell viability assay changes cellular metabolic characteristics by intervening with glycolysis and pentose phosphate pathway. Chem Res Toxicol 37(2):208\u2013211","journal-title":"Chem Res Toxicol"},{"issue":"5","key":"11279_CR19","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2015","unstructured":"Ferlay J et al (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 136(5):E359\u2013E386","journal-title":"Int J Cancer"},{"issue":"37","key":"11279_CR20","doi-asserted-by":"crossref","first-page":"6750","DOI":"10.3748\/wjg.v23.i37.6750","volume":"23","author":"TN Flores-T\u00e9llez","year":"2017","unstructured":"Flores-T\u00e9llez TN, Villa-Trevi\u00f1o S, Pi\u00f1a-V\u00e1zquez C (2017) Road to stemness in hepatocellular carcinoma. World J Gastroenterol 23(37):6750\u20136776","journal-title":"World J Gastroenterol"},{"key":"11279_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20081817","author":"MG Francipane","year":"2019","unstructured":"Francipane MG, Bulanin D, Lagasse E (2019) Establishment and characterization of 5-fluorouracil-resistant human colorectal cancer stem-like cells: tumor dynamics under selection pressure. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms20081817","journal-title":"Int J Mol Sci"},{"key":"11279_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25163700","author":"T Ganesan","year":"2020","unstructured":"Ganesan T et al (2020) Annexin A1: a bane or a boon in cancer? A systematic review. Molecules. https:\/\/doi.org\/10.3390\/molecules25163700","journal-title":"Molecules"},{"issue":"5","key":"11279_CR23","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.stem.2007.08.014","volume":"1","author":"C Ginestier","year":"2007","unstructured":"Ginestier C et al (2007) ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1(5):555\u2013567","journal-title":"Cell Stem Cell"},{"issue":"5","key":"11279_CR24","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.devcel.2005.09.010","volume":"9","author":"MV Gustafsson","year":"2005","unstructured":"Gustafsson MV et al (2005) Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell 9(5):617\u2013628","journal-title":"Dev Cell"},{"key":"11279_CR25","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/978-1-4939-2694-7_47","volume":"1312","author":"VM Harris","year":"2015","unstructured":"Harris VM (2015) Protein detection by Simple Western\u2122 analysis. Methods Mol Biol 1312:465\u2013468","journal-title":"Methods Mol Biol"},{"issue":"8","key":"11279_CR26","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s12276-018-0128-8","volume":"50","author":"L He","year":"2018","unstructured":"He L et al (2018) Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells. Exp Mol Med 50(8):101","journal-title":"Exp Mol Med"},{"issue":"1","key":"11279_CR27","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41392-021-00828-5","volume":"6","author":"Y He","year":"2021","unstructured":"He Y et al (2021) Targeting PI3K\/Akt signal transduction for cancer therapy. Signal Transduct Target Ther 6(1):425","journal-title":"Signal Transduct Target Ther"},{"key":"11279_CR28","doi-asserted-by":"crossref","first-page":"846","DOI":"10.3389\/fphar.2018.00846","volume":"9","author":"KW Hon","year":"2018","unstructured":"Hon KW et al (2018) MiRNAs and lncRNAs as predictive biomarkers of response to FOLFOX therapy in colorectal cancer. Front Pharmacol 9:846","journal-title":"Front Pharmacol"},{"issue":"1","key":"11279_CR29","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/sj.onc.1209016","volume":"25","author":"L Hummerich","year":"2006","unstructured":"Hummerich L et al (2006) Identification of novel tumour-associated genes differentially expressed in the process of squamous cell cancer development. Oncogene 25(1):111\u2013121","journal-title":"Oncogene"},{"issue":"8_Supplement","key":"11279_CR30","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1158\/1538-7445.AM2013-526","volume":"73","author":"AR Hussain","year":"2013","unstructured":"Hussain AR et al (2013) Abstract 526: combined inhibition of mTOR and AKT activity induces potent apoptosis in epithelial ovarian cancer cells. Cancer Res 73(8_Supplement):526\u2013526","journal-title":"Cancer Res"},{"issue":"1","key":"11279_CR31","first-page":"117","volume":"8","author":"JS Kang","year":"2002","unstructured":"Kang JS et al (2002) Dysregulation of annexin I protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer. Clin Cancer Res 8(1):117\u2013123","journal-title":"Clin Cancer Res"},{"issue":"4","key":"11279_CR32","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.3892\/or.2016.4597","volume":"35","author":"J Kim","year":"2016","unstructured":"Kim J et al (2016) Effects of HSP27 downregulation on PDT resistance through PDT-induced autophagy in head and neck cancer cells. Oncol Rep 35(4):2237\u20132245","journal-title":"Oncol Rep"},{"issue":"8","key":"11279_CR33","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.4161\/auto.6.8.13549","volume":"6","author":"J Lian","year":"2010","unstructured":"Lian J, Karnak D, Xu L (2010) The Bcl-2-Beclin 1 interaction in (-)-gossypol-induced autophagy versus apoptosis in prostate cancer cells. Autophagy 6(8):1201\u20131203","journal-title":"Autophagy"},{"issue":"13","key":"11279_CR34","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1128\/MCB.05160-11","volume":"31","author":"CG Liao","year":"2011","unstructured":"Liao CG et al (2011) Characterization of basigin isoforms and the inhibitory function of basigin-3 in human hepatocellular carcinoma proliferation and invasion. Mol Cell Biol 31(13):2591\u20132604","journal-title":"Mol Cell Biol"},{"issue":"6","key":"11279_CR35","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/jso.20992","volume":"97","author":"CY Lin","year":"2008","unstructured":"Lin CY et al (2008) Nuclear localization of annexin A1 is a prognostic factor in oral squamous cell carcinoma. J Surg Oncol 97(6):544\u2013550","journal-title":"J Surg Oncol"},{"issue":"12","key":"11279_CR36","doi-asserted-by":"crossref","first-page":"6063","DOI":"10.1158\/0008-5472.CAN-06-0054","volume":"66","author":"S Liu","year":"2006","unstructured":"Liu S et al (2006) Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res 66(12):6063\u20136071","journal-title":"Cancer Res"},{"issue":"9","key":"11279_CR37","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/s41419-020-02998-6","volume":"11","author":"R Liu","year":"2020","unstructured":"Liu R et al (2020) PI3K\/AKT pathway as a key link modulates the multidrug resistance of cancers. Cell Death Dis 11(9):797","journal-title":"Cell Death Dis"},{"issue":"140","key":"11279_CR38","first-page":"880","volume":"62","author":"Q Ma","year":"2015","unstructured":"Ma Q et al (2015) Rapamycin-mediated mTOR inhibition reverses drug resistance to Adriamycin in colon cancer cells. Hepatogastroenterology 62(140):880\u2013886","journal-title":"Hepatogastroenterology"},{"issue":"12","key":"11279_CR39","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1158\/1078-0432.CCR-09-2846","volume":"16","author":"AA Merchant","year":"2010","unstructured":"Merchant AA, Matsui W (2010) Targeting hedgehog\u2013a cancer stem cell pathway. Clin Cancer Res 16(12):3130\u20133140","journal-title":"Clin Cancer Res"},{"key":"11279_CR40","doi-asserted-by":"crossref","first-page":"114398","DOI":"10.1016\/j.biopha.2023.114398","volume":"160","author":"S Mukherjee","year":"2023","unstructured":"Mukherjee S et al (2023) Targeting mitochondria as a potential therapeutic strategy against chemoresistance in cancer. Biomed Pharmacother 160:114398","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"11279_CR41","doi-asserted-by":"crossref","first-page":"551","DOI":"10.34172\/apb.2023.053","volume":"13","author":"S Najafi","year":"2023","unstructured":"Najafi S et al (2023) CD44 suppression improved the chemosensitivity of HT-29 colorectal cancer cells to 5-fluorouracil and inhibited cell migration. Adv Pharm Bull 13(3):551\u2013562","journal-title":"Adv Pharm Bull"},{"key":"11279_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13174363","author":"CM Neophytou","year":"2021","unstructured":"Neophytou CM et al (2021) Apoptosis deregulation and the development of cancer multi-drug resistance. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers13174363","journal-title":"Cancers (Basel)"},{"issue":"12","key":"11279_CR43","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/nrc1232","volume":"3","author":"R Pardal","year":"2003","unstructured":"Pardal R, Clarke MF, Morrison SJ (2003) Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 3(12):895\u2013902","journal-title":"Nat Rev Cancer"},{"key":"11279_CR44","doi-asserted-by":"crossref","first-page":"819128","DOI":"10.3389\/fonc.2022.819128","volume":"12","author":"Y Peng","year":"2022","unstructured":"Peng Y et al (2022) PI3K\/Akt\/mTOR pathway and its role in cancer therapeutics: are we making headway? Front Oncol 12:819128","journal-title":"Front Oncol"},{"issue":"1","key":"11279_CR45","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/nri2470","volume":"9","author":"M Perretti","year":"2009","unstructured":"Perretti M, D\u2019Acquisto F (2009) Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. Nat Rev Immunol 9(1):62\u201370","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"11279_CR46","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/j.1476-5381.2009.00483.x","volume":"158","author":"M Perretti","year":"2009","unstructured":"Perretti M, Dalli J (2009) Exploiting the Annexin A1 pathway for the development of novel anti-inflammatory therapeutics. Br J Pharmacol 158(4):936\u2013946","journal-title":"Br J Pharmacol"},{"issue":"4","key":"11279_CR47","doi-asserted-by":"crossref","first-page":"e94621","DOI":"10.1371\/journal.pone.0094621","volume":"9","author":"SH Sahlberg","year":"2014","unstructured":"Sahlberg SH et al (2014) Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells. PLoS ONE 9(4):e94621","journal-title":"PLoS ONE"},{"issue":"5","key":"11279_CR48","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3109\/07357907.2012.659925","volume":"30","author":"AB Sarmento-Ribeiro","year":"2012","unstructured":"Sarmento-Ribeiro AB et al (2012) Apoptosis deregulation influences chemoresistance to azaguanine in human leukemic cell lines. Cancer Invest 30(5):331\u2013342","journal-title":"Cancer Invest"},{"issue":"8","key":"11279_CR49","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1111\/bph.12183","volume":"169","author":"A Sinclair","year":"2013","unstructured":"Sinclair A, Latif AL, Holyoake TL (2013) Targeting survival pathways in chronic myeloid leukaemia stem cells. Br J Pharmacol 169(8):1693\u20131707","journal-title":"Br J Pharmacol"},{"issue":"12","key":"11279_CR50","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1158\/1078-0432.CCR-09-2943","volume":"16","author":"F Takahashi-Yanaga","year":"2010","unstructured":"Takahashi-Yanaga F, Kahn M (2010) Targeting Wnt signaling: can we safely eradicate cancer stem cells? Clin Cancer Res 16(12):3153\u20133162","journal-title":"Clin Cancer Res"},{"issue":"1","key":"11279_CR51","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1182\/blood-2007-03-080796","volume":"111","author":"J Tamburini","year":"2008","unstructured":"Tamburini J et al (2008) Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase\/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways. Blood 111(1):379\u2013382","journal-title":"Blood"},{"issue":"1","key":"11279_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10495-007-0154-9","volume":"13","author":"A Thorburn","year":"2008","unstructured":"Thorburn A (2008) Apoptosis and autophagy: regulatory connections between two supposedly different processes. Apoptosis 13(1):1\u20139","journal-title":"Apoptosis"},{"key":"11279_CR53","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-1-61779-080-5_20","volume":"731","author":"J van Meerloo","year":"2011","unstructured":"van Meerloo J, Kaspers GJ, Cloos J (2011) Cell sensitivity assays: the MTT assay. Methods Mol Biol 731:237\u2013245","journal-title":"Methods Mol Biol"},{"issue":"15","key":"11279_CR54","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1158\/1078-0432.CCR-06-0483","volume":"12","author":"KL Wang","year":"2006","unstructured":"Wang KL et al (2006) Expression of annexin A1 in esophageal and esophagogastric junction adenocarcinomas: association with poor outcome. Clin Cancer Res 12(15):4598\u20134604","journal-title":"Clin Cancer Res"},{"issue":"4","key":"11279_CR55","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1177\/147323000803600407","volume":"36","author":"LD Wang","year":"2008","unstructured":"Wang LD et al (2008) Decreased expression of annexin A1 during the progression of cervical neoplasia. J Int Med Res 36(4):665\u2013672","journal-title":"J Int Med Res"},{"issue":"1","key":"11279_CR56","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3390\/ph16010070","volume":"16","author":"X Wang","year":"2023","unstructured":"Wang X et al (2023) Targeting Annexin A1 as a druggable player to enhance the anti-tumor role of Honokiol in colon cancer through autophagic pathway. Pharmaceuticals 16(1):70","journal-title":"Pharmaceuticals"},{"key":"11279_CR57","unstructured":"(WHO), W.H.O. Cancer. 2022 13 January 2022]; https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cancer"},{"issue":"10","key":"11279_CR58","doi-asserted-by":"crossref","first-page":"101174","DOI":"10.1016\/j.tranon.2021.101174","volume":"14","author":"Y Xi","year":"2021","unstructured":"Xi Y, Xu P (2021) Global colorectal cancer burden in 2020 and projections to 2040. Transl Oncol 14(10):101174","journal-title":"Transl Oncol"},{"issue":"2","key":"11279_CR59","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s00253-019-10257-8","volume":"104","author":"Z Xu","year":"2020","unstructured":"Xu Z et al (2020) Targeting PI3K\/AKT\/mTOR-mediated autophagy for tumor therapy. Appl Microbiol Biotechnol 104(2):575\u2013587","journal-title":"Appl Microbiol Biotechnol"},{"issue":"12","key":"11279_CR60","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1016\/j.biocel.2012.08.022","volume":"44","author":"Z Yu","year":"2012","unstructured":"Yu Z et al (2012) Cancer stem cells. Int J Biochem Cell Biol 44(12):2144\u20132151","journal-title":"Int J Biochem Cell Biol"},{"key":"11279_CR61","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.semcancer.2021.06.019","volume":"85","author":"L Yu","year":"2022","unstructured":"Yu L, Wei J, Liu P (2022) Attacking the PI3K\/Akt\/mTOR signaling pathway for targeted therapeutic treatment in human cancer. Semin Cancer Biol 85:69\u201394","journal-title":"Semin Cancer Biol"},{"issue":"41","key":"11279_CR62","doi-asserted-by":"publisher","first-page":"5497","DOI":"10.1038\/onc.2008.245","volume":"27","author":"TL Yuan","year":"2008","unstructured":"Yuan TL, Cantley LC (2008) PI3K pathway alterations in cancer: variations on a theme. Oncogene 27(41):5497\u20135510","journal-title":"Oncogene"},{"issue":"70","key":"11279_CR63","doi-asserted-by":"crossref","first-page":"33403","DOI":"10.18632\/oncotarget.23607","volume":"9","author":"Y Zhou","year":"2018","unstructured":"Zhou Y et al (2018) Cancer stem cells in progression of colorectal cancer. Oncotarget 9(70):33403\u201333415","journal-title":"Oncotarget"},{"issue":"12","key":"11279_CR64","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/s41419-018-1204-7","volume":"9","author":"JF Zhu","year":"2018","unstructured":"Zhu JF et al (2018) Annexin A1-suppressed autophagy promotes nasopharyngeal carcinoma cell invasion and metastasis by PI3K\/AKT signaling activation. Cell Death Dis 9(12):1154","journal-title":"Cell Death Dis"},{"issue":"7","key":"11279_CR65","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1111\/jcmm.17221","volume":"26","author":"W Zou","year":"2022","unstructured":"Zou W et al (2022) SiRNA-induced CD44 knockdown suppresses the proliferation and invasion of colorectal cancer stem cells through inhibiting epithelial-mesenchymal transition. J Cell Mol Med 26(7):1969\u20131978","journal-title":"J Cell Mol Med"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-025-11279-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-025-11279-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-025-11279-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:08:05Z","timestamp":1784621285000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10528-025-11279-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["11279"],"URL":"https:\/\/doi.org\/10.1007\/s10528-025-11279-w","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]},"assertion":[{"value":"24 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no potential conflicts of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"During the preparation of this work the authors used GPT-4 to improve sentence structures where needed. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.","order":2,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}