{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:01:46Z","timestamp":1784624506547,"version":"3.55.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Zhejiang Medical and Health Science Project","award":["2023RC114"],"award-info":[{"award-number":["2023RC114"]}]},{"name":"the Public welfare project of Lishui Science and Technology Bureau","award":["2023GYX69"],"award-info":[{"award-number":["2023GYX69"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s10528-026-11333-1","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T15:21:38Z","timestamp":1771341698000},"page":"6077-6092","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ERBB2 as a Prognostic Biomarker in Prostate Cancer: Integration of Single-Cell Transcriptomics, Deep Learning, and Immunohistochemical Validation"],"prefix":"10.1007","volume":"64","author":[{"given":"Chen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Bo","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng-Fei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Ping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Tao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Lin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Peng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"issue":"2","key":"11333_CR15","doi-asserted-by":"publisher","first-page":"101399","DOI":"10.1016\/j.xcrm.2024.101399","volume":"5","author":"X Bao","year":"2024","unstructured":"Bao X, Li Q, Chen D, Dai X, Liu C, Tian W et al (2024) A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer. Cell Rep Med 5(2):101399","journal-title":"Cell Rep Med"},{"issue":"6","key":"11333_CR27","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1016\/j.immuni.2023.05.008","volume":"56","author":"AE Baxter","year":"2023","unstructured":"Baxter AE, Huang H, Giles JR, Chen Z, Wu JE, Drury S et al (2023) The SWI\/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8(+) T cells. Immunity 56(6):1320\u201340e10","journal-title":"Immunity"},{"issue":"4","key":"11333_CR34","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41419-021-03686-9","volume":"12","author":"Y Bi","year":"2021","unstructured":"Bi Y, Gong L, Liu P, Xiong X, Zhao Y (2021) Nuclear ErbB2 represses DEPTOR transcription to inhibit autophagy in breast cancer cells. Cell Death Dis 12(4):397","journal-title":"Cell Death Dis"},{"issue":"2","key":"11333_CR5","doi-asserted-by":"publisher","first-page":"240","DOI":"10.2967\/jnumed.120.261886","volume":"63","author":"JJ Cerci","year":"2022","unstructured":"Cerci JJ, Fanti S, Lobato EE, Kunikowska J, Alonso O, Medina S et al (2022) Diagnostic performance and clinical impact of (68)Ga-PSMA-11 PET\/CT imaging in early relapsed prostate cancer after radical therapy: a prospective multicenter study (IAEA-PSMA study). J Nucl Med 63(2):240\u2013247","journal-title":"J Nucl Med"},{"issue":"1","key":"11333_CR3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/biomedicines13010025","volume":"13","author":"CF Chang","year":"2024","unstructured":"Chang CF, Chen LC, Chen YT, Huang CY, Yu CC, Lin VC et al (2024) Unveiling DENND2D as a novel prognostic biomarker for prostate cancer recurrence: from gene to prognosis. Biomedicines 13(1):25","journal-title":"Biomedicines"},{"issue":"1","key":"11333_CR36","doi-asserted-by":"publisher","first-page":"6377","DOI":"10.1038\/s41467-021-26612-1","volume":"12","author":"M Che","year":"2021","unstructured":"Che M, Chaturvedi A, Munro SA, Pitzen SP, Ling A, Zhang W et al (2021) Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer. Nat Commun 12(1):6377","journal-title":"Nat Commun"},{"key":"11333_CR20","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/978-1-4939-7493-1_12","volume":"1711","author":"B Chen","year":"2018","unstructured":"Chen B, Khodadoust MS, Liu CL, Newman AM, Alizadeh AA (2018) Profiling tumor infiltrating immune cells with CIBERSORT. Methods Mol Biol 1711:243\u2013259","journal-title":"Methods Mol Biol"},{"issue":"11","key":"11333_CR28","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.2967\/jnumed.119.241109","volume":"61","author":"AC de Jong","year":"2020","unstructured":"de Jong AC, Smits M, van Riet J, F\u00fctterer JJ, Brabander T, Hamberg P et al (2020) (68)Ga-PSMA-guided bone biopsies for molecular diagnostics in patients with metastatic prostate cancer. J Nucl Med 61(11):1607\u20131614","journal-title":"J Nucl Med"},{"key":"11333_CR22","doi-asserted-by":"publisher","first-page":"152219","DOI":"10.1016\/j.anndiagpath.2023.152219","volume":"67","author":"F Estephan","year":"2023","unstructured":"Estephan F, Lap CJ, Banagan J, Antonio M, Liu S, Diao G et al (2023) The prevalence and clinical significance of HER2 expression in prostate adenocarcinoma. Annals Diagn Pathol 67:152219","journal-title":"Annals Diagn Pathol"},{"key":"11333_CR37","doi-asserted-by":"crossref","unstructured":"Fang H, Ren W, Cui Q, Liang H, Yang C, Liu W et al (2023) Integrin \u03b24 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2\/IQGAP1\/RAC1. eLife. 12:RP88483","DOI":"10.7554\/eLife.88483.3"},{"issue":"14","key":"11333_CR32","doi-asserted-by":"publisher","first-page":"3672","DOI":"10.1158\/1078-0432.CCR-15-2309","volume":"22","author":"S Gao","year":"2016","unstructured":"Gao S, Ye H, Gerrin S, Wang H, Sharma A, Chen S et al (2016) ErbB2 signaling increases androgen receptor expression in abiraterone-resistant prostate cancer. Clin Cancer Res 22(14):3672\u20133682","journal-title":"Clin Cancer Res"},{"issue":"8","key":"11333_CR7","doi-asserted-by":"publisher","first-page":"e006343","DOI":"10.1136\/jitc-2022-006343","volume":"11","author":"G Gao","year":"2023","unstructured":"Gao G, Liao W, Shu P, Ma Q, He X, Zhang B et al (2023) Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of Proinflammatory macrophages to improve antitumor efficacy of CAR-T cells against solid tumor. J Immunother Cancer 11(8):e006343","journal-title":"J Immunother Cancer"},{"issue":"1","key":"11333_CR29","doi-asserted-by":"publisher","first-page":"pbad001","DOI":"10.1093\/pcmedi\/pbad001","volume":"6","author":"T Guo","year":"2023","unstructured":"Guo T, Yuan Z, Wang T, Zhang J, Tang H, Zhang N et al (2023) Integrative analysis of ferroptosis regulators for clinical prognosis based on deep learning and potential chemotherapy sensitivity of prostate cancer. Precision Clin Med 6(1):pbad001","journal-title":"Precision Clin Med"},{"issue":"1","key":"11333_CR25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12920-022-01172-5","volume":"15","author":"D Hu","year":"2022","unstructured":"Hu D, Cao Q, Tong M, Ji C, Li Z, Huang W et al (2022) A novel defined risk signature based on pyroptosis-related genes can predict the prognosis of prostate cancer. BMC Med Genom 15(1):24","journal-title":"BMC Med Genom"},{"issue":"1","key":"11333_CR19","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12874-018-0482-1","volume":"18","author":"JL Katzman","year":"2018","unstructured":"Katzman JL, Shaham U, Cloninger A, Bates J, Jiang T, Kluger Y (2018) DeepSurv: personalized treatment recommender system using a Cox proportional hazards deep neural network. BMC Med Res Methodol 18(1):24","journal-title":"BMC Med Res Methodol"},{"key":"11333_CR1","doi-asserted-by":"publisher","first-page":"101132","DOI":"10.1016\/j.neo.2025.101132","volume":"61","author":"E Lehtonen","year":"2025","unstructured":"Lehtonen E, Vertanen M, Syv\u00e4l\u00e4 H, Tolonen T, Auriola S, Tammela T et al (2025) The impact of Atorvastatin on intraprostatic biomarkers - prognostic value of 3LS-score - follow-up of ESTO1-trial. Neoplasia 61:101132","journal-title":"Neoplasia"},{"issue":"16","key":"11333_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms23169325","volume":"23","author":"C Li","year":"2022","unstructured":"Li C, Dou P, Lu X, Guan P, Lin Z, Zhou Y et al (2022) Identification and validation of TRIM25 as a glucose metabolism regulator in prostate cancer. Int J Mol Sci 23(16):1\u20139","journal-title":"Int J Mol Sci"},{"key":"11333_CR9","doi-asserted-by":"publisher","first-page":"1168191","DOI":"10.3389\/fimmu.2023.1168191","volume":"14","author":"C Li","year":"2023","unstructured":"Li C, Guan R, Li W, Wei D, Cao S, Xu C et al (2023) Single-cell RNA sequencing reveals tumor immune microenvironment in human hypopharygeal squamous cell carcinoma and lymphatic metastasis. Front Immunol 14:1168191","journal-title":"Front Immunol"},{"issue":"1","key":"11333_CR14","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1186\/s12967-024-05503-1","volume":"22","author":"G Li","year":"2024","unstructured":"Li G, Liu X, Gu C, Ma G, Li S, Ma Z et al (2024) Mutual exclusivity and co-occurrence patterns of immune checkpoints indicate NKG2A relates to anti-PD-1 resistance in gastric cancer. J Transl Med 22(1):718","journal-title":"J Transl Med"},{"issue":"1","key":"11333_CR13","doi-asserted-by":"publisher","first-page":"10849","DOI":"10.1038\/s41467-024-55146-5","volume":"15","author":"X Liao","year":"2024","unstructured":"Liao X, Kang L, Peng Y, Chai X, Xie P, Lin C et al (2024) Multivariate stochastic modeling for transcriptional dynamics with cell-specific latent time using SDEvelo. Nat Commun 15(1):10849","journal-title":"Nat Commun"},{"issue":"6","key":"11333_CR2","doi-asserted-by":"publisher","first-page":"3429","DOI":"10.1016\/j.acra.2024.12.006","volume":"32","author":"NB Lomer","year":"2024","unstructured":"Lomer NB, Ashoobi MA, Ahmadzadeh AM, Sotoudeh H, Tabari A, Torigian DA (2024) MRI-based radiomics for predicting prostate cancer grade groups: a systematic review and meta-analysis of diagnostic test accuracy studies. Acad Radiol 32(6):3429\u20133452","journal-title":"Acad Radiol"},{"issue":"5","key":"11333_CR18","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1093\/bib\/bbae466","volume":"25","author":"R Rajadnya","year":"2024","unstructured":"Rajadnya R, Sharma N, Mahajan A, Ulhe A, Patil R, Hegde M et al (2024) Novel systems biology experimental pipeline reveals matairesinol\u2019s antimetastatic potential in prostate cancer: an integrated approach of network pharmacology, bioinformatics, and experimental validation. Brief Bioinform 25(5):5","journal-title":"Brief Bioinform"},{"issue":"13","key":"11333_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/JCI180071","volume":"134","author":"JB Rubin","year":"2024","unstructured":"Rubin JB, Abou-Antoun T, Ippolito JE, Llaci L, Marquez CT, Wong JP et al (2024) Epigenetic developmental mechanisms underlying sex differences in cancer. J Clin Investig 134(13):1\u201310","journal-title":"J Clin Investig"},{"issue":"1","key":"11333_CR21","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.celrep.2018.03.086","volume":"23","author":"J Saltz","year":"2018","unstructured":"Saltz J, Gupta R, Hou L, Kurc T, Singh P, Nguyen V et al (2018) Spatial organization and molecular correlation of tumor-infiltrating lymphocytes using deep learning on pathology images. Cell Rep 23(1):181\u201393e7","journal-title":"Cell Rep"},{"issue":"1","key":"11333_CR10","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/s41392-024-01885-2","volume":"9","author":"X Shi","year":"2024","unstructured":"Shi X, Wang X, Yao W, Shi D, Shao X, Lu Z et al (2024) Mechanism insights and therapeutic intervention of tumor metastasis: latest developments and perspectives. Signal Transduct Target Therapy 9(1):192","journal-title":"Signal Transduct Target Therapy"},{"key":"11333_CR31","doi-asserted-by":"publisher","first-page":"175883592412993","DOI":"10.1177\/17588359241299324","volume":"17","author":"B Shouki","year":"2025","unstructured":"Shouki B, Abdelsalam A, Abdullah AS, Kanan A, Ahmed AS, Emad D et al (2025) Management of metastatic colorectal cancer: consensus in the Gulf Cooperation Council countries. Therapeutic Adv Med Oncol 17:17588359241299324","journal-title":"Therapeutic Adv Med Oncol"},{"issue":"17","key":"11333_CR4","doi-asserted-by":"publisher","first-page":"13603","DOI":"10.3390\/ijms241713603","volume":"24","author":"JX Sun","year":"2023","unstructured":"Sun JX, An Y, Xiang JC, Xu JZ, Hu J, Wang SG et al (2023) The prognosis-predictive and immunoregulatory role of sumoylation related genes: potential novel targets in prostate cancer treatment. Int J Mol Sci 24(17):13603","journal-title":"Int J Mol Sci"},{"issue":"6","key":"11333_CR33","doi-asserted-by":"publisher","first-page":"e99525","DOI":"10.1371\/journal.pone.0099525","volume":"9","author":"J Tome-Garcia","year":"2014","unstructured":"Tome-Garcia J, Li D, Ghazaryan S, Shu L, Wu L (2014) ERBB2 increases metastatic potentials specifically in androgen-insensitive prostate cancer cells. PLoS ONE 9(6):e99525","journal-title":"PLoS ONE"},{"issue":"1","key":"11333_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/bib\/bbad507","volume":"25","author":"S Wang","year":"2023","unstructured":"Wang S, Shen B, Guo L, Shang M, Liu J, Sun Q et al (2023) ScFed: federated learning for cell type classification with scRNA-seq. Brief Bioinform 25(1):1\u20139","journal-title":"Brief Bioinform"},{"issue":"1","key":"11333_CR6","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41420-025-02354-7","volume":"11","author":"G Wei","year":"2025","unstructured":"Wei G, Huang Y, Li W, Xie Y, Zhang D, Niu Y et al (2025) SREBF1-based metabolic reprogramming in prostate cancer promotes tumor ferroptosis resistance. Cell Death Discovery 11(1):75","journal-title":"Cell Death Discovery"},{"issue":"1","key":"11333_CR16","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1186\/s12967-023-04663-w","volume":"21","author":"F Yan","year":"2023","unstructured":"Yan F, Jiang L, Ye F, Ping J, Bowley TY, Ness SA et al (2023) Deep neural network based tissue Deconvolution of Circulating tumor cell RNA. J Transl Med 21(1):783","journal-title":"J Transl Med"},{"issue":"8","key":"11333_CR8","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/s41419-023-06050-1","volume":"14","author":"C Yang","year":"2023","unstructured":"Yang C, Ou Y, Zhou Q, Liang Y, Li W, Chen Y et al (2023) Methionine orchestrates the metabolism vulnerability in cisplatin resistant bladder cancer microenvironment. Cell Death Dis 14(8):525","journal-title":"Cell Death Dis"},{"issue":"12","key":"11333_CR35","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s00262-024-03846-8","volume":"73","author":"J Yang","year":"2024","unstructured":"Yang J, Chen Y, Zhang X, Tong Z, Weng S, Zhu N et al (2024) Immunotherapy May be more appropriate for ERBB2 low-expressing extramammary paget\u2019s disease patients: a prognosis analysis and exploration of targeted therapy and immunotherapy of extramammary paget\u2019s disease patients. Cancer Immunol Immunother 73(12):252","journal-title":"Cancer Immunol Immunother"},{"issue":"1","key":"11333_CR24","doi-asserted-by":"publisher","first-page":"17064","DOI":"10.1038\/s41598-022-20775-7","volume":"12","author":"B Ye","year":"2022","unstructured":"Ye B, Ding K, Li K, Zhu Q (2022) Study on the role of SLC14A1 gene in biochemical recurrence of prostate cancer. Sci Rep 12(1):17064","journal-title":"Sci Rep"},{"issue":"5","key":"11333_CR30","doi-asserted-by":"publisher","first-page":"477","DOI":"10.24272\/j.issn.2095-8137.2020.095","volume":"41","author":"L Zeng","year":"2020","unstructured":"Zeng L, Li W, Chen CS (2020) Breast cancer animal models and applications. Zool Res 41(5):477\u2013494","journal-title":"Zool Res"},{"issue":"1","key":"11333_CR17","doi-asserted-by":"publisher","first-page":"5261","DOI":"10.1038\/s41467-021-25534-2","volume":"12","author":"Y Zhao","year":"2021","unstructured":"Zhao Y, Cai H, Zhang Z, Tang J, Li Y (2021) Learning interpretable cellular and gene signature embeddings from single-cell transcriptomic data. Nat Commun 12(1):5261","journal-title":"Nat Commun"},{"issue":"2","key":"11333_CR11","doi-asserted-by":"publisher","first-page":"596","DOI":"10.7150\/thno.78687","volume":"13","author":"Y Zhao","year":"2023","unstructured":"Zhao Y, Wen S, Li H, Pan CW, Wei Y, Huang T et al (2023) Enhancer RNA promotes resistance to radiotherapy in bone-metastatic prostate cancer by m(6)A modification. Theranostics 13(2):596\u2013610","journal-title":"Theranostics"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-026-11333-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-026-11333-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-026-11333-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:07:48Z","timestamp":1784621268000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10528-026-11333-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,17]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["11333"],"URL":"https:\/\/doi.org\/10.1007\/s10528-026-11333-1","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,17]]},"assertion":[{"value":"19 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}