{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T09:09:57Z","timestamp":1788685797640,"version":"build-2803163510"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"2023 Autonomous Region Health Commission Science and Technology Project for the Development of High-Level Clinical Specialties in Public Hospitals in the Capital Region","award":["2023SGGZ076-02"],"award-info":[{"award-number":["2023SGGZ076-02"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s10528-026-11395-1","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:38:27Z","timestamp":1780324707000},"page":"7449-7464","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LncRNA CCAT1\/miR-490-3p\/VDAC1 Axis Promotes Colorectal Cancer Progression by Activating Glycolysis"],"prefix":"10.1007","volume":"64","author":[{"given":"Yongli","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"11395_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15010033","author":"S Argueti-Ostrovsky","year":"2024","unstructured":"Argueti-Ostrovsky S, Barel S, Kahn J et al (2024) VDAC1: a key player in the mitochondrial landscape of neurodegeneration. Biomolecules. https:\/\/doi.org\/10.3390\/biom15010033","journal-title":"Biomolecules"},{"key":"11395_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/biom14101304","author":"T Arif","year":"2024","unstructured":"Arif T, Shteinfer-Kuzmine A, Shoshan-Barmatz V (2024) Decoding cancer through silencing the mitochondrial gatekeeper VDAC1. Biomolecules. https:\/\/doi.org\/10.3390\/biom14101304","journal-title":"Biomolecules"},{"issue":"4","key":"11395_CR3","doi-asserted-by":"publisher","first-page":"e159","DOI":"10.1038\/mtna.2014.9","volume":"3","author":"T Arif","year":"2014","unstructured":"Arif T, Vasilkovsky L, Refaely Y et al (2014) Silencing VDAC1 expression by siRNA inhibits cancer cell proliferation and tumor growth in vivo. Mol Ther Nucleic Acids 3(4):e159","journal-title":"Mol Ther Nucleic Acids"},{"key":"11395_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/biom10010135","author":"R Avolio","year":"2020","unstructured":"Avolio R, Matassa DS, Criscuolo D et al (2020) Modulation of mitochondrial metabolic reprogramming and oxidative stress to overcome chemoresistance in cancer. Biomolecules. https:\/\/doi.org\/10.3390\/biom10010135","journal-title":"Biomolecules"},{"issue":"19","key":"11395_CR5","doi-asserted-by":"publisher","first-page":"9199","DOI":"10.1111\/jcmm.16815","volume":"25","author":"J Chen","year":"2021","unstructured":"Chen J, Alduais Y, Zhang K et al (2021) CCAT1\/FABP5 promotes tumour progression through mediating fatty acid metabolism and stabilizing PI3K\/AKT\/mTOR signalling in lung adenocarcinoma. J Cell Mol Med 25(19):9199\u2013213","journal-title":"J Cell Mol Med"},{"issue":"10207","key":"11395_CR6","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","volume":"394","author":"E Dekker","year":"2019","unstructured":"Dekker E, Tanis PJ, Vleugels JLA et al (2019) Colorectal cancer. Lancet 394(10207):1467\u20131480","journal-title":"Lancet"},{"key":"11395_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/cells8121492","author":"L Ding","year":"2019","unstructured":"Ding L, Gu H, Xiong X et al (2019) MicroRNAs involved in carcinogenesis, prognosis, therapeutic resistance and applications in human triple-negative breast cancer. Cells Basel. https:\/\/doi.org\/10.3390\/cells8121492","journal-title":"Cells Basel"},{"key":"11395_CR8","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12935-019-1081-x","volume":"20","author":"S Ding","year":"2020","unstructured":"Ding S, Jin Y, Hao Q et al (2020) LncRNA BCYRN1\/miR-490-3p\/POU3F2, served as a ceRNA network, is connected with worse survival rate of hepatocellular carcinoma patients and promotes tumor cell growth and metastasis [J]. Cancer Cell Int 20:6","journal-title":"Cancer Cell Int"},{"key":"11395_CR9","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.omtn.2020.07.005","volume":"21","author":"D Fu","year":"2020","unstructured":"Fu D, Shi Y, Liu JB (2020) Targeting long non-coding RNA to therapeutically regulate gene expression in cancer. Mol Ther Nucleic Acids 21:712\u201324","journal-title":"Mol Ther Nucleic Acids"},{"issue":"10","key":"11395_CR10","doi-asserted-by":"publisher","first-page":"17975","DOI":"10.1002\/jcb.29064","volume":"120","author":"J Guo","year":"2019","unstructured":"Guo J, Ma Y, Peng X et al (2019) LncRNA CCAT1 promotes autophagy via regulating ATG7 by sponging miR-181 in hepatocellular carcinoma. J Cell Biochem 120(10):17975\u201383","journal-title":"J Cell Biochem"},{"issue":"4","key":"11395_CR11","doi-asserted-by":"publisher","first-page":"790","DOI":"10.7150\/ijms.105553","volume":"22","author":"K He","year":"2025","unstructured":"He K, Tao F, Lu Y et al (2025) The Role of HK2 in tumorigenesis and development: potential for targeted therapy with natural products. Int J Med Sci 22(4):790\u2013805","journal-title":"Int J Med Sci"},{"issue":"1","key":"11395_CR12","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s10020-023-00663-0","volume":"29","author":"L Huang","year":"2023","unstructured":"Huang L, Wei B, Zhao Y et al (2023) DYNLT1 promotes mitochondrial metabolism to fuel breast cancer development by inhibiting ubiquitination degradation of VDAC1. Mol Med 29(1):72","journal-title":"Mol Med"},{"issue":"12","key":"11395_CR13","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/s41575-019-0189-8","volume":"16","author":"N Keum","year":"2019","unstructured":"Keum N, Giovannucci E (2019) Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies. Nat Rev Gastroenterol Hepatol 16(12):713\u201332","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"9","key":"11395_CR14","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1002\/ijc.26218","volume":"130","author":"R Kumarswamy","year":"2012","unstructured":"Kumarswamy R, Mudduluru G, Ceppi P et al (2012) MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer. Int J Cancer 130(9):2044\u20132053","journal-title":"Int J Cancer"},{"issue":"2","key":"11395_CR15","first-page":"322","volume":"22","author":"XJ Lai","year":"2018","unstructured":"Lai XJ, Cheng HF (2018) LncRNA colon cancer-associated transcript 1 (CCAT1) promotes proliferation and metastasis of ovarian cancer via miR-1290. Eur Rev Med Pharmacol Sci 22(2):322\u20138","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"11395_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-021-02226-1","volume":"19","author":"J Li","year":"2021","unstructured":"Li J, Mo R, Zheng L (2021) MicroRNA-490-3p inhibits migration and chemoresistance of colorectal cancer cells via targeting TNKS2. World J Surg Oncol 19(1):117","journal-title":"World J Surg Oncol"},{"issue":"8","key":"11395_CR17","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s13238-019-0618-z","volume":"10","author":"T Li","year":"2019","unstructured":"Li T, Han J (2019) PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation. Protein Cell 10(8):583\u2013594","journal-title":"Protein Cell"},{"issue":"1","key":"11395_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.541","volume":"6","author":"MZ Ma","year":"2015","unstructured":"Ma MZ, Chu BF, Zhang Y et al (2015) Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p. Cell Death Dis 6(1):e1583","journal-title":"Cell Death Dis"},{"issue":"1","key":"11395_CR19","first-page":"31","volume":"58","author":"Z Ning","year":"2020","unstructured":"Ning Z, Tan G (2020) [Cancer metabolism: a novel perspective on precision diagnosis and treatment for liver cancer]. Zhonghua Wai Ke Za Zhi 58(1):31\u20136","journal-title":"Zhonghua Wai Ke Za Zhi"},{"issue":"Pt 3","key":"11395_CR20","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1016\/j.semcancer.2022.09.007","volume":"86","author":"S Paul","year":"2022","unstructured":"Paul S, Ghosh S, Kumar S (2022) Tumor glycolysis, an essential sweet tooth of tumor cells. Semin Cancer Biol 86(Pt 3):1216\u201330","journal-title":"Semin Cancer Biol"},{"issue":"4","key":"11395_CR21","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1158\/0008-5472.CAN-14-1301","volume":"75","author":"J Shen","year":"2015","unstructured":"Shen J, Xiao Z, Wu WK et al (2015) Epigenetic silencing of miR-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-induced gastric carcinogenesis [J]. Cancer Res 75(4):754\u2013765","journal-title":"Cancer Res"},{"issue":"40","key":"11395_CR22","doi-asserted-by":"publisher","first-page":"4435","DOI":"10.2174\/0929867324666170616105200","volume":"24","author":"V Shoshan-Barmatz","year":"2017","unstructured":"Shoshan-Barmatz V, Krelin Y, Chen Q (2017) VDAC1 as a player in mitochondria-mediated apoptosis and target for modulating apoptosis. Curr Med Chem 24(40):4435\u201346","journal-title":"Curr Med Chem"},{"issue":"1","key":"11395_CR23","doi-asserted-by":"publisher","first-page":"767","DOI":"10.3892\/ol.2017.6210","volume":"14","author":"R Song","year":"2017","unstructured":"Song R, Cong L, NI G et al (2017) MicroRNA-195 inhibits the behavior of cervical cancer tumors by directly targeting HDGF. Oncol Lett 14(1):767\u2013775","journal-title":"Oncol Lett"},{"key":"11395_CR24","doi-asserted-by":"publisher","first-page":"108939","DOI":"10.1016\/j.cbi.2020.108939","volume":"317","author":"M Song","year":"2020","unstructured":"Song M, Wang X, Luo Y et al (2020) Cantharidin suppresses gastric cancer cell migration\/invasion by inhibiting the PI3K\/Akt signaling pathway via CCAT1. Chem Biol Interact 317:108939","journal-title":"Chem Biol Interact"},{"key":"11395_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/cells8111465","author":"CJ Stavast","year":"2019","unstructured":"Stavast CJ, Erkeland SJ (2019) The non-canonical aspects of MicroRNAs: many roads to gene regulation. Cells Basel. https:\/\/doi.org\/10.3390\/cells8111465","journal-title":"Cells Basel"},{"issue":"6","key":"11395_CR26","first-page":"2343","volume":"53","author":"W Sun","year":"2018","unstructured":"Sun W, Shi Y, Wang Z (2018) Interaction of long-chain non-coding RNAs and important signaling pathways on human cancers (review). Int J Oncol 53(6):2343\u201355","journal-title":"Int J Oncol"},{"issue":"7","key":"11395_CR27","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1080\/09553002.2019.1589653","volume":"95","author":"P Vaupel","year":"2019","unstructured":"Vaupel P, Schmidberger H, Mayer A (2019) The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression. Int J Radiat Biol 95(7):912\u20139","journal-title":"Int J Radiat Biol"},{"issue":"3","key":"11395_CR28","first-page":"1247","volume":"53","author":"B Wang","year":"2018","unstructured":"Wang B, Yin M, Cheng C et al (2018) Decreased expression of miR\u2011490\u20113p in colorectal cancer predicts poor prognosis and promotes cell proliferation and invasion by targeting RAB14. Int J Oncol 53(3):1247\u201356","journal-title":"Int J Oncol"},{"issue":"1","key":"11395_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0909-7","volume":"17","author":"H Wang","year":"2018","unstructured":"Wang H, Chen W, Jin M et al (2018) CircSLC3A2 functions as an oncogenic factor in hepatocellular carcinoma by sponging miR-490-3p and regulating PPM1F expression. Mol Cancer 17(1):165","journal-title":"Mol Cancer"},{"key":"11395_CR30","volume":"2022","author":"Z Wang","year":"2022","unstructured":"Wang Z, Cheng Y, Song Z et al (2022) Pan-cancer analysis of voltage-dependent anion channel (VDAC1) as a cancer therapeutic target or diagnostic biomarker. Dis Markers 2022:5946110","journal-title":"Dis Markers"},{"issue":"3","key":"11395_CR31","doi-asserted-by":"publisher","first-page":"143","DOI":"10.21873\/cgp.20027","volume":"14","author":"UH Weidle","year":"2017","unstructured":"Weidle UH, Birzele F, Kollmorgen G et al (2017) Long Non-coding RNAs and their role in metastasis. Cancer Genom Proteom 14(3):143\u2013160","journal-title":"Cancer Genom Proteom"},{"issue":"10","key":"11395_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101174","volume":"14","author":"Y Xi","year":"2021","unstructured":"Xi Y, Xu P (2021) Global colorectal cancer burden in 2020 and projections to 2040. Transl Oncol 14(10):101174","journal-title":"Transl Oncol"},{"issue":"1","key":"11395_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-11644-4","volume":"12","author":"C Xia","year":"2022","unstructured":"Xia C, Sun Y, Li Y et al (2022) LncRNA CCAT1 enhances chemoresistance in hepatocellular carcinoma by targeting QKI-5. Sci Rep 12(1):7826","journal-title":"Sci Rep"},{"issue":"3","key":"11395_CR34","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/cpr.12252","volume":"49","author":"Y Xin","year":"2016","unstructured":"Xin Y, LI Z, Shen J et al (2016) CCAT1: a pivotal oncogenic long non-coding RNA in human cancers. Cell Prolif 49(3):255\u2013260","journal-title":"Cell Prolif"},{"issue":"2","key":"11395_CR35","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.18632\/aging.102634","volume":"12","author":"W Xu","year":"2020","unstructured":"Xu W, Yu S, Xiong J et al (2020) CeRNA regulatory network-based analysis to study the roles of noncoding RNAs in the pathogenesis of intrahepatic cholangiocellular carcinoma. Aging 12(2):1047\u20131086","journal-title":"Aging"},{"issue":"2","key":"11395_CR36","first-page":"975","volume":"18","author":"Z Yang","year":"2019","unstructured":"Yang Z, Ji G (2019) Fusobacterium nucleatum-positive colorectal cancer. Oncol Lett 18(2):975\u201382","journal-title":"Oncol Lett"},{"issue":"8","key":"11395_CR37","doi-asserted-by":"publisher","first-page":"3725","DOI":"10.1007\/s10620-021-07187-9","volume":"67","author":"F Yang","year":"2022","unstructured":"Yang F, Peng ZX, Ji WD et al (2022) LncRNA CCAT1 upregulates ATG5 to enhance autophagy and promote gastric cancer development by absorbing miR-140-3p. Dig Dis Sci 67(8):3725\u201341","journal-title":"Dig Dis Sci"},{"issue":"3","key":"11395_CR38","doi-asserted-by":"publisher","first-page":"e3470","DOI":"10.1002\/jgm.3470","volume":"25","author":"N Yu","year":"2023","unstructured":"Yu N, Qin H, Zhang F et al (2023) The role and mechanism of long non-coding RNAs in homologous recombination repair of radiation-induced DNA damage. J Gene Med 25(3):e3470","journal-title":"J Gene Med"},{"issue":"1","key":"11395_CR39","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-023-02827-6","volume":"42","author":"C Zhang","year":"2023","unstructured":"Zhang C, Wang H, Liu Q et al (2023) LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement. J Exp Clin Cancer Res 42(1):246","journal-title":"J Exp Clin Cancer Res"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-026-11395-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-026-11395-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-026-11395-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T08:11:06Z","timestamp":1788682266000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10528-026-11395-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["11395"],"URL":"https:\/\/doi.org\/10.1007\/s10528-026-11395-1","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]},"assertion":[{"value":"27 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures were approved by the Animal Ethics Committee of People\u2019s Hospital of Inner Mongolia Autonomous Region (Approval No.: KY202410) and complied with the ARRIVE guidelines and national standards for laboratory animal welfare.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}