{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T20:30:23Z","timestamp":1793478623279,"version":"4.5.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"2023 Jiangxi Provincial Natural Science Foundation General Project","award":["20232BAB206039"],"award-info":[{"award-number":["20232BAB206039"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Biochem Genet"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10528-026-11442-x","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:07:45Z","timestamp":1786691265000},"page":"8461-8479","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["miR-4632-5p Alleviates Lumbar Disc Degeneration by Targeting MAP3K11: A Novel Role in Mitigating Nucleus Pulposus Cell Degeneration"],"prefix":"10.1007","volume":"64","author":[{"given":"Xinfei","family":"Lan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mianlong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canhua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"issue":"21","key":"11442_CR1","doi-asserted-by":"publisher","first-page":"18338","DOI":"10.18632\/oncotarget.4274","volume":"6","author":"AL Binch","year":"2015","unstructured":"Binch AL, Cole AA, Breakwell LM, Michael AL, Chiverton N, Creemers LB, Cross AK, Le Maitre CL (2015) Class 3 semaphorins expression and association with innervation and angiogenesis within the degenerate human intervertebral disc. Oncotarget 6(21):18338\u201318354","journal-title":"Oncotarget"},{"issue":"1","key":"11442_CR2","first-page":"134","volume":"45","author":"JL Chen","year":"2023","unstructured":"Chen JL, Wang S, Wang MC, Wang X (2023) [Research Progressin the Relationship between Interleukin-6 and Intervertebral Disc Degeneration]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 45(1):134\u2013142","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"11442_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154928","volume":"123","author":"H Chen","year":"2024","unstructured":"Chen H, Han X, Zhang Y, Wang K, Liu D, Hu Z, Wang J (2024) Bruceine D suppresses CAF-promoted TNBC metastasis under TNF-\u03b1 stimulation by inhibiting Notch1-Jagged1\/NF-\u03baB(p65) signaling. Phytomedicine 123:154928","journal-title":"Phytomedicine"},{"issue":"1","key":"11442_CR4","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1186\/s13018-024-05280-z","volume":"19","author":"H Chen","year":"2024","unstructured":"Chen H, Tang T, Xue C, Liu X, Xi Z, Xie L, Kang R (2024) Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration. J Orthop Surg Res 19(1):825","journal-title":"J Orthop Surg Res"},{"key":"11442_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10121063","author":"S Cui","year":"2020","unstructured":"Cui S, Zhou Z, Liu X, Richards RG, Alini M, Peng S, Liu S, Zou X, Li Z, Grad S (2020) Identification and characterization of serum microRNAs as biomarkers for human disc degeneration: an RNA sequencing analysis. Diagnostics (Basel). https:\/\/doi.org\/10.3390\/diagnostics10121063","journal-title":"Diagnostics (Basel)"},{"issue":"5","key":"11442_CR6","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12664","volume":"52","author":"W Dong","year":"2019","unstructured":"Dong W, Liu J, Lv Y, Wang F, Liu T, Sun S, Liao B, Shu Z, Qian J (2019) MiR-640 aggravates intervertebral disc degeneration via NF-\u03baB and WNT signalling pathway. Cell Prolif 52(5):e12664","journal-title":"Cell Prolif"},{"issue":"1","key":"11442_CR7","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1186\/s12951-024-02556-8","volume":"22","author":"C Fan","year":"2024","unstructured":"Fan C, Wang W, Yu Z, Wang J, Xu W, Ji Z, He W, Hua D, Wang W, Yao L et al (2024) M1 macrophage-derived exosomes promote intervertebral disc degeneration by enhancing nucleus pulposus cell senescence through LCN2\/NF-\u03baB signaling axis. J Nanobiotechnol 22(1):301","journal-title":"J Nanobiotechnol"},{"key":"11442_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2024.115214","volume":"207","author":"HH Genedy","year":"2024","unstructured":"Genedy HH, Humbert P, Laoulaou B, Le Moal B, Fusellier M, Passirani C, Le Visage C, Guicheux J, Lepeltier \u00c9, Clouet J (2024) MicroRNA-targeting nanomedicines for the treatment of intervertebral disc degeneration. Adv Drug Deliv Rev 207:115214","journal-title":"Adv Drug Deliv Rev"},{"key":"11442_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101902","volume":"87","author":"L Kang","year":"2023","unstructured":"Kang L, Zhang H, Jia C, Zhang R, Shen C (2023) Epigenetic modifications of inflammation in intervertebral disc degeneration. Ageing Res Rev 87:101902","journal-title":"Ageing Res Rev"},{"key":"11442_CR10","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.wneu.2021.09.066","volume":"157","author":"S Kirnaz","year":"2022","unstructured":"Kirnaz S, Capadona C, Wong T, Goldberg JL, Medary B, Sommer F, McGrath LB Jr., H\u00e4rtl R (2022) Fundamentals of intervertebral disc degeneration. World Neurosurg 157:264\u2013273","journal-title":"World Neurosurg"},{"key":"11442_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2023.112181","volume":"177","author":"H Li","year":"2023","unstructured":"Li H, Wang X, Pan H, Xiao C, Wang C, Guo S, Long L, Shi H, Chen H, Li S (2023) The mechanisms and functions of IL-1\u03b2 in intervertebral disc degeneration. Exp Gerontol 177:112181","journal-title":"Exp Gerontol"},{"issue":"1","key":"11442_CR12","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1186\/s13018-025-06069-4","volume":"20","author":"Y Liu","year":"2025","unstructured":"Liu Y, Huang L, Gao Z, Hou Y, Kong F, Hou S, Li Z (2025) miR-340-5p alleviates the damage effect of LPS on nucleus pulposus cells by negatively regulating the expression of SOX4. J Orthop Surg Res 20(1):690","journal-title":"J Orthop Surg Res"},{"issue":"1","key":"11442_CR13","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1186\/s13018-024-05017-y","volume":"19","author":"C Liu","year":"2024","unstructured":"Liu C, Ge X, Li Y (2024) Repair of annulus fibrosus defects using decellularized annulus fibrosus matrix\/chitosan hybrid hydrogels. J Orthop Surg Res 19(1):535","journal-title":"J Orthop Surg Res"},{"issue":"1","key":"11442_CR14","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12916-025-03849-x","volume":"23","author":"S Mitsunaga","year":"2025","unstructured":"Mitsunaga S, Ikeda M, Ueno M, Kobayashi S, Tsuda M, Miki I, Kuwahara T, Hara K, Takayama Y, Matsunaga Y et al (2025) Robust circulating microRNA signature for the diagnosis and early detection of pancreatobiliary cancer. BMC Med 23(1):23","journal-title":"BMC Med"},{"issue":"1","key":"11442_CR15","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1093\/bmb\/ldz015","volume":"130","author":"A Oliviero","year":"2019","unstructured":"Oliviero A, Della Porta G, Peretti GM, Maffulli N (2019) MicroRNA in osteoarthritis: physiopathology, diagnosis and therapeutic challenge. Br Med Bull 130(1):137\u2013147","journal-title":"Br Med Bull"},{"issue":"4","key":"11442_CR16","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1080\/15548627.2023.2274205","volume":"20","author":"Y Song","year":"2024","unstructured":"Song Y, Liang H, Li G, Ma L, Zhu D, Zhang W, Tong B, Li S, Gao Y, Wu X et al (2024) The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn(2+) trafficking. Autophagy 20(4):809\u2013829","journal-title":"Autophagy"},{"key":"11442_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.857164","volume":"10","author":"K Suyama","year":"2022","unstructured":"Suyama K, Sakai D, Watanabe M (2022) The role of IL-17-mediated inflammatory processes in the pathogenesis of intervertebral disc degeneration and herniation: a comprehensive review. Front Cell Dev Biol 10:857164","journal-title":"Front Cell Dev Biol"},{"issue":"4","key":"11442_CR18","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1002\/cbin.11767","volume":"46","author":"JH Tan","year":"2022","unstructured":"Tan JH, Li ZP, Liu LL, Liu H, Xue JB (2022) IL-17 in intervertebral disc degeneration: Mechanistic insights and therapeutic implications. Cell Biol Int 46(4):535\u2013547","journal-title":"Cell Biol Int"},{"key":"11442_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/cells13242103","author":"W Taylor","year":"2024","unstructured":"Taylor W, Erwin WM (2024) Intervertebral disc degeneration and regeneration: new molecular mechanisms and therapeutics: obstacles and potential breakthrough technologies. Cells. https:\/\/doi.org\/10.3390\/cells13242103","journal-title":"Cells"},{"key":"11442_CR20","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1186\/1756-0500-4-470","volume":"4","author":"M Uhl","year":"2011","unstructured":"Uhl M, Mellert K, Striegl B, Deibler M, Lamla M, Spatz JP, Kemkemer R, Kaufmann D (2011) Cyclic stretch increases splicing noise rate in cultured human fibroblasts. BMC Res Notes 4:470","journal-title":"BMC Res Notes"},{"key":"11442_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26073226","author":"L Vajarintarangoon","year":"2025","unstructured":"Vajarintarangoon L, Limthongkul W, Singhatanadgige W, Kotheeranurak V, Yingsakmongkol W, Thongtan T, Dechsupa S, Honsawek S (2025) Downregulation and hypermethylation of vitamin D receptor in lumbar disc degeneration. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms26073226","journal-title":"Int J Mol Sci"},{"issue":"2","key":"11442_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.111505","volume":"28","author":"Y Wang","year":"2025","unstructured":"Wang Y, Peng Y, Hao W, He C, Gao X, Liang P, Zhao H, Wang Y, Wang L, Yu Z et al (2025) Trillin inhibits MAP3K11\/NF-\u03baB\/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer. iScience 28(2):111505","journal-title":"iScience"},{"issue":"1","key":"11442_CR23","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1186\/s13018-024-05196-8","volume":"19","author":"B Zhang","year":"2024","unstructured":"Zhang B, Dong B, Wang L, Wang Y, Gao Z, Li Y, Wang H, Lu X (2024) Comparison of the efficacy of autologous Lp-PRP and Lr-PRP for treating intervertebral disc degeneration: in vitro and in vivo study. J Orthop Surg Res 19(1):731","journal-title":"J Orthop Surg Res"},{"key":"11442_CR24","doi-asserted-by":"publisher","DOI":"10.2174\/0115665240370788250617070218","author":"W Zhang","year":"2025","unstructured":"Zhang W, Zhang P, Zhan J, Wei X, Du Y, Zhao K, Zhu L, Xie R, Xie H, Zhou S et al (2025) Role of exosomes from nucleus pulposus cells in attenuating intervertebral disc degeneration by inhibiting nucleus pulposus cell apoptosis via the miR-8485\/GSK-3\u03b2\/Wnt\/\u03b2-catenin signaling axis. Curr Mol Med. https:\/\/doi.org\/10.2174\/0115665240370788250617070218","journal-title":"Curr Mol Med"},{"issue":"18","key":"11442_CR25","doi-asserted-by":"publisher","first-page":"22459","DOI":"10.18632\/aging.203553","volume":"13","author":"Y Zhao","year":"2021","unstructured":"Zhao Y, Li A (2021) miR-19b-3p relieves intervertebral disc degeneration through modulating PTEN\/PI3K\/Akt\/mTOR signaling pathway. Aging 13(18):22459\u201322473","journal-title":"Aging"},{"issue":"1","key":"11442_CR26","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1186\/s13018-025-05999-3","volume":"20","author":"C Zhao","year":"2025","unstructured":"Zhao C, Li Q, Shen C (2025) Therapeutic potential of miR-204-5p in intervertebral disc degeneration: targeting the SSRP1\/NF-\u03baB pathway to inhibit apoptosis. J Orthop Surg Res 20(1):586","journal-title":"J Orthop Surg Res"},{"issue":"4","key":"11442_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.1221","volume":"12","author":"Y Zhu","year":"2024","unstructured":"Zhu Y, He J, Wei R, Liu J (2024) Construction and experimental validation of a novel ferroptosis-related gene signature for myelodysplastic syndromes. Immun Inflamm Dis 12(4):e1221","journal-title":"Immun Inflamm Dis"}],"container-title":["Biochemical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-026-11442-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-026-11442-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10528-026-11442-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T20:02:14Z","timestamp":1793476934000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10528-026-11442-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,14]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["11442"],"URL":"https:\/\/doi.org\/10.1007\/s10528-026-11442-x","relation":{},"ISSN":["0006-2928","1573-4927"],"issn-type":[{"value":"0006-2928","type":"print"},{"value":"1573-4927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,14]]},"assertion":[{"value":"30 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by The Ethics Committee of Beijing University of Chinese Medicine Third Affiliated Hospital (JDF-IRB-2020110403). All procedures performed in studies involving human participants were in accordance with the 1964 Helsinki Declaration and later versions. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.","order":2,"name":"Ethics","label":"Ethics Approval and Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All patients provided written informed consent.","order":3,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}