{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:53:28Z","timestamp":1789386808878,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"19","license":[{"start":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T00:00:00Z","timestamp":1153872000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotechnol Lett"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1007\/s10529-006-9122-7","type":"journal-article","created":{"date-parts":[[2006,7,25]],"date-time":"2006-07-25T09:22:25Z","timestamp":1153819345000},"page":"1527-1535","source":"Crossref","is-referenced-by-count":110,"title":["Methylglyoxal Bypass Identified as Source of Chiral Contamination in l(+) and d(\u2212)-lactate Fermentations by Recombinant Escherichia coli"],"prefix":"10.1007","volume":"28","author":[{"given":"T. B.","family":"Grabar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. T.","family":"Shanmugam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. P.","family":"Yomano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. O.","family":"Ingram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,7,26]]},"reference":[{"key":"9122_CR1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1081\/MC-120025975","volume":"4","author":"AK Agrawal","year":"2003","unstructured":"Agrawal AK (2003) Advances in the production of poly(lactic acid) fibers. A review. J Macromol Sci Polym Rev 4:479\u2013503","journal-title":"J Macromol Sci Polym Rev"},{"key":"9122_CR2","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.1128\/jb.173.16.5144-5150.1991","volume":"173","author":"J Badia","year":"1991","unstructured":"Badia J, Gimenez R, Baldoma L, Barnes E, Fessner WD, Aguilar J (1991) l-Lyxose metabolism employs the l-rhamnose pathway in mutant-cells of Escherichia coli-adapted to grow on xylose. J Bacteriol 173:5144\u20135150","journal-title":"J Bacteriol"},{"key":"9122_CR3","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.1128\/AEM.67.12.5621-5625.2001","volume":"67","author":"MM Bianchi","year":"2001","unstructured":"Bianchi MM, Brambilla L, Protani F, Liu C, Lievense, Porro D (2001) Efficient homolactic fermentation by Kluveromyces lactis strains defective in pyruvate utilization and transformed with heterologous LDH gene. Appl Environ Microbiol 67:5621\u20135625","journal-title":"Appl Environ Microbiol"},{"key":"9122_CR4","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1042\/bst0311406","volume":"31","author":"IR Booth","year":"2003","unstructured":"Booth IR, Ferguson GP, Miller S, Li C, Gunasekera B, Kinghorn S (2003) Bacterial production of methylglyoxal: a survival strategy or death by misadventure?. Biochem Soc Trans 31:1406\u20131408","journal-title":"Biochem Soc Trans"},{"key":"9122_CR5","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1073\/pnas.0308171100","volume":"101","author":"TB Causey","year":"2004","unstructured":"Causey TB, Shanmugam KT, Yomano LP, Ingram LO (2004) Engineering Escherichia coli for efficient conversion of glucose to pyruvate. Proc Natl Acad Sci USA 101:2235\u20132240","journal-title":"Proc Natl Acad Sci USA"},{"key":"9122_CR6","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1128\/AEM.65.4.1384-1389.1999","volume":"65","author":"DE Chang","year":"1999","unstructured":"Chang DE, Jung HC, Rhee JS, Pan JG (1999) Homofermentative production of d(\u2212) or l(+) lactate in metabolically engineered Escherichia coli RR1. Appl Environ Microbiol 65:1384\u20131389","journal-title":"Appl Environ Microbiol"},{"key":"9122_CR7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1146\/annurev.mi.45.100191.003033","volume":"45","author":"LN Csonka","year":"1991","unstructured":"Csonka LN (1991) Prokaryotic osmoregulation: genetics and physiology. Annu Rev Microbiol 45:569\u2013606","journal-title":"Annu Rev Microbiol"},{"key":"9122_CR8","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","volume":"97","author":"KA Datsenko","year":"2000","unstructured":"Datsenko KA, Wanner BL (2000) One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci USA 97:6640\u20136645","journal-title":"Proc Natl Acad Sci USA"},{"key":"9122_CR9","first-page":"23","volume":"11","author":"A Demirci","year":"1992","unstructured":"Demirci A, Pometto AL (1992) Enhanced production of d(\u2212)-lactic acid by mutants of Lactobacillus delbrueckii ATCC9649. J Ind Microbiol Biotechnol 11:23\u201328","journal-title":"J Ind Microbiol Biotechnol"},{"key":"9122_CR10","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/sj.jim.7000195","volume":"27","author":"BS Dien","year":"2001","unstructured":"Dien BS, Nichols NN, Bothast RJ (2001) Recombinant Escherichia coli engineered for production of l-lactic acid from hexose and pentose sugars. J Indus Microbiol Biotechnol 27:259\u2013264","journal-title":"J Indus Microbiol Biotechnol"},{"key":"9122_CR11","unstructured":"Eddington JM, Johnson KB, Liaw HJ, Rowe M, Yang Y (2004) Novel lactobacillus strains and use thereof in fermentation process for l-lactic acid production. US Patent Application No. 20040005677"},{"key":"9122_CR12","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1128\/AEM.66.9.3835-3841.2000","volume":"66","author":"K Kyla-Nikkila","year":"2000","unstructured":"Kyla-Nikkila K, Hujanen M, Leisola M, Palva A (2000) Metabolic engineering of Lactobacillus helveticus CNR32 for production of pure l(+)-lactic acid. Appl Environ Microbiol 66:3835\u20133841","journal-title":"Appl Environ Microbiol"},{"key":"9122_CR13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/mabi.200300096","volume":"4","author":"SY Lee","year":"2004","unstructured":"Lee SY, Hong SH, Lee SH, Park SJ (2004) Fermentative production of chemicals that can be used for polymer synthesis. Macromol Biosci 4:157\u2013164","journal-title":"Macromol Biosci"},{"key":"9122_CR14","unstructured":"Liaw HJ (2003) Novel strains of Rhizopus oryzae and uses thereof US Patent Application No. 20030003553"},{"key":"9122_CR15","unstructured":"Liu CL, Lievense JC (2005) Lactic acid producing yeast. US Patent Application No. 20050112737"},{"key":"9122_CR16","doi-asserted-by":"crossref","first-page":"7143","DOI":"10.1128\/JB.181.22.7143-7148.1999","volume":"181","author":"F Martinez-Morales","year":"1999","unstructured":"Martinez-Morales F, Borges AG, Martinez A, Shanmugam KT, Ingram LO (1999) Chromosomal integration of heterologous DNA in Escherichia coli with precise removal of markers and replicons during construction. J Bacteriol 181:7143\u20137148","journal-title":"J Bacteriol"},{"key":"9122_CR17","volume-title":"A short course in bacterial genetics: a laboratory manual and handbook for Escherichia Coli and related bacteria","author":"JH Miller","year":"1992","unstructured":"Miller JH, (1992) A short course in bacterial genetics: a laboratory manual and handbook for Escherichia Coli and related bacteria. Cold Spring Harbor Press, Cold Spring Harbor, NY"},{"key":"9122_CR18","first-page":"167","volume":"7","author":"N Narayanan","year":"2004","unstructured":"Narayanan N, Roychoudhury PK, Srivastava A (2004) l(+) lactic acid fermentation and its product polymerization. Electron J Biotechnol 7:167\u2013179","journal-title":"Electron J Biotechnol"},{"key":"9122_CR19","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1128\/AEM.65.9.4211-4215.1999","volume":"65","author":"D Porro","year":"1999","unstructured":"Porro D, Michele MB, Luca B, Rossella M, Davide B, Vittorio C, Jefferson L, Liu CL, Bianca MR, Laura F, Lillia A (1999) Replacement of a metabolic pathway for large-scale production of lactic acid from engineered yeasts. Appl Environ Microbiol 65:4211\u20134215","journal-title":"Appl Environ Microbiol"},{"key":"9122_CR20","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1128\/AEM.71.7.3761-3769.2005","volume":"71","author":"JE Purvis","year":"2005","unstructured":"Purvis JE, Yomano LP, Ingram LO (2005) Enhanced trehalose production improves growth of Escherichia coli under osmotic stress. Appl Environ Microbiol 71:3761\u20133769","journal-title":"Appl Environ Microbiol"},{"key":"9122_CR21","doi-asserted-by":"crossref","first-page":"4426","DOI":"10.1128\/jb.179.13.4426-4428.1997","volume":"179","author":"G. Posfai","year":"1997","unstructured":"Posfai G., Koob MD, Kirkpatrick HA, Blattner FC (1997) Versatile insertion plasmids for targeted genome manipulations in bacteria: Isolation, deletion, and rescue of the pathogenicity island LEE of the Escherichia coli O157:H7 genome. J Bacteriol 179:4426\u20134428","journal-title":"J Bacteriol"},{"key":"9122_CR22","unstructured":"Rajgarhia V, Dundon CA, Olson S, Suominen P, Hause B (2004) Methods and materials for the production of d-lactic acid in yeast. US Patent Application No. 20040029256"},{"key":"9122_CR23","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.pmatsci.2005.05.002","volume":"50","author":"SS Ray","year":"2005","unstructured":"Ray SS, Bousmina M (2005) Biodegradable polymers and their layered silicate nano composites: in greening the 21st century world. Prog Mat Sci 50:962\u20131079","journal-title":"Prog Mat Sci"},{"key":"9122_CR24","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1128\/AEM.71.5.2789-2792.2005","volume":"71","author":"S Saitoh","year":"2005","unstructured":"Saitoh S, Ishida N, Onishi T, Tokuhiro, Nagamori E, Kitamota K, Takahashi H (2005) Genetically engineered wine yeast produces a high concentration of l-lactic acid of extremely high optical purity. Appl Environ Microbiol 71:2789\u20132792","journal-title":"Appl Environ Microbiol"},{"key":"9122_CR25","volume-title":"Molecular cloning: a laboratory manual","author":"J Sambrook","year":"2001","unstructured":"Sambrook J, Russell DW (2001) Molecular cloning: a laboratory manual. Cold Spring Harbor Press, Cold Spring Harbor, NY"},{"key":"9122_CR26","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1128\/AEM.66.6.2343-2348.2000","volume":"66","author":"CD Skory","year":"2000","unstructured":"Skory CD (2000) Isolation and expression of lactate dehydrogenase genes from Rhizopus oryzae. Appl Environ Microbiol 66:2343\u20132348","journal-title":"Appl Environ Microbiol"},{"key":"9122_CR27","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1046\/j.1365-2958.1998.00700.x","volume":"27","author":"S Totemeyer","year":"1998","unstructured":"Totemeyer S, Booth NA, Nichols WW, Dunbar B, Booth IR (1998) From famine to feast: the role of methylglyoxal production in Escherichia coli. Mol Microbiol 27:553\u2013562","journal-title":"Mol Microbiol"},{"key":"9122_CR28","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1080\/10643380590966181","volume":"35","author":"AN Vaidya","year":"2005","unstructured":"Vaidya AN, Pandey RA, Mudliar S, Kumar MS, Chakrabarti T, Devotta S (2005) Production and recovery of lactic acid for polylactide\u2014an overview. Crit Rev Environ Sci Technol 35:429\u2013467","journal-title":"Crit Rev Environ Sci Technol"},{"key":"9122_CR29","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1128\/AEM.70.5.2898-2905.2004","volume":"70","author":"AJA Maris van","year":"2004","unstructured":"van Maris AJA, Winkler AA, Porro D, van Dijken JP, Pronk JT (2004) Homofermentative lactate production cannot sustain anaerobic growth of engineered Saccharomyces cerevisiae: possible consequence of energy-dependent lactate export. Appl Environ Microbiol 70:2898\u20132905","journal-title":"Appl Environ Microbiol"},{"key":"9122_CR30","first-page":"159","volume":"19","author":"KL Wasewar","year":"2005","unstructured":"Wasewar KL (2005) Separation of lactic acid: recent advances. Chem Biochem Eng Quart 19:159\u2013172","journal-title":"Chem Biochem Eng Quart"},{"key":"9122_CR31","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1099\/mic.0.27482-0","volume":"151","author":"J Weber","year":"2005","unstructured":"Weber J, Kayser A, Rinas U (2005) Metabolic flux analysis of Escherichia coli in glucose-limited continuous culture. II. Dynamic response to famine and feast, activation of the methylglyoxal pathway and oscillatory behaviour. Microbiology 151:707\u2013716","journal-title":"Microbiology"},{"key":"9122_CR32","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1128\/AEM.69.1.399-407.2003","volume":"69","author":"S Zhou","year":"2003a","unstructured":"Zhou S, Causey TB, Hasona A, Shanmugam KT, Ingram LO (2003a) Production of optically pure d-lactic acid in mineral salt medium by metabolically engineered Escherichia coli W3110. Appl Environ Microbiol 69:399\u2013407","journal-title":"Appl Environ Microbiol"},{"key":"9122_CR33","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1128\/AEM.69.4.2237-2244.2003","volume":"69","author":"S Zhou","year":"2003b","unstructured":"Zhou S, Shanmugam KT, Ingram LO (2003b) Functional replacement of the Escherichia coli d(-)-lactate dehydrogenase gene (ldhA) with the l(+)-lactate dehydrogenase gene (ldhL) from Pediococcus acidilactici. Appl Environ Microbiol 69:2237\u20132244","journal-title":"Appl Environ Microbiol"},{"key":"9122_CR34","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1007\/s10529-005-3899-7","volume":"27","author":"S Zhou","year":"2005","unstructured":"Zhou S, Yomano LP, Shanmugam KT, Ingram LO (2005) Fermentation of 10% (w\/v) sugar to d(\u2212)-lactate by engineered Escherichia coli B. Biotechnol Lett 27:1891\u20131896","journal-title":"Biotechnol Lett"},{"key":"9122_CR35","doi-asserted-by":"crossref","unstructured":"Zhou S, Grabar TB, Shanmugam KT, Ingram LO (2006a) Betaine tripled the volumetric productivity of d(\u2212)-lactate by Escherichia coli B strain SZ132 in mineral salts medium. Biotechnol Lett 28:000\u2013000","DOI":"10.1007\/s10529-006-0033-4"},{"key":"9122_CR36","doi-asserted-by":"crossref","unstructured":"Zhou S, Shanmugam KT, Yomano LP, Grabar TB, Ingram LO (2006b) Fermentation of 12% (w\/v) glucose to 1.2\u00a0M lactate by Escherichia coli B strain SZ194 using mineral salts medium. Biotechnol Lett 28:000\u2013000","DOI":"10.1007\/s10529-006-0032-5"},{"key":"9122_CR37","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1006\/mben.2001.0186","volume":"3","author":"MM Zhu","year":"2001","unstructured":"Zhu MM, Skraly FA, Cameron DC (2001) Accumulation of methylglyoxal in anaerobically grown Escherichia coli and its detoxification by expression of the Pseudomonas putida glyoxalase I gene. Metab Eng 3:218\u2013225","journal-title":"Metab Eng"}],"container-title":["Biotechnology Letters"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-006-9122-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10529-006-9122-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-006-9122-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T12:10:51Z","timestamp":1587125451000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10529-006-9122-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,26]]},"references-count":37,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["9122"],"URL":"https:\/\/doi.org\/10.1007\/s10529-006-9122-7","relation":{},"ISSN":["0141-5492","1573-6776"],"issn-type":[{"value":"0141-5492","type":"print"},{"value":"1573-6776","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,26]]}}}