{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:10:04Z","timestamp":1790100604686,"version":"4.0.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T00:00:00Z","timestamp":1253145600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotechnol Lett"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1007\/s10529-009-0123-1","type":"journal-article","created":{"date-parts":[[2009,9,16]],"date-time":"2009-09-16T05:14:56Z","timestamp":1253078096000},"page":"59-66","source":"Crossref","is-referenced-by-count":75,"title":["Preparation of cross-linked carboxymethyl chitosan for repairing sciatic nerve injury in rats"],"prefix":"10.1007","volume":"32","author":[{"given":"Gan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Ao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yandao","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiufang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,9,17]]},"reference":[{"key":"123_CR1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1163\/1568562053992496","volume":"16","author":"W Cao","year":"2005","unstructured":"Cao W, Cheng M, Ao Q, Gong Y, Zhao N, Zhang X (2005) Physical, mechanical and degradation properties, and Schwann cell affinity of cross-linked chitosan films. J Biomater Sci Polym Ed 16:791\u2013807","journal-title":"J Biomater Sci Polym Ed"},{"key":"123_CR2","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S0142-9612(98)00018-0","volume":"15","author":"LJ Chamberlain","year":"1998","unstructured":"Chamberlain LJ, Yannas IV, Arrizabalaga A, Hsu HP, Norregaard TV, Spector M (1998) Early peripheral nerve healing in collagen and silicone tube implants: myofibroblasts and the cellular response. Biomaterials 15:1393\u20131403","journal-title":"Biomaterials"},{"key":"123_CR3","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/(SICI)1097-4547(20000601)60:5<666::AID-JNR12>3.0.CO;2-0","volume":"60","author":"LJ Chamberlain","year":"2000","unstructured":"Chamberlain LJ, Yannas IV, Hsu HP, Strichartz GR, Spector M (2000) Near-terminus axonal structure and function following rat sciatic nerve regeneration through a collagen\u2013GAG matrix in a ten-millimeter gap. J Neurosci Res 60:666\u2013677","journal-title":"J Neurosci Res"},{"key":"123_CR4","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1016\/S0142-9612(02)00207-7","volume":"23","author":"X Chen","year":"2002","unstructured":"Chen X, Wang Z, Liu W, Park H (2002) The effect of carboxymethyl chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts. Biomaterials 23:4609\u20134614","journal-title":"Biomaterials"},{"key":"123_CR5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0167-7799(97)01165-7","volume":"16","author":"CA Heath","year":"1998","unstructured":"Heath CA, Rutkowski GE (1998) The development of bioartificial nerve grafts for peripheral nerve regeneration. Trends Biotechnol 16:163\u2013168","journal-title":"Trends Biotechnol"},{"key":"123_CR6","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1016\/S0142-9612(03)00026-7","volume":"24","author":"E Khor","year":"2003","unstructured":"Khor E, Lim LY (2003) Implantable applications of chitin and chitosan. Biomaterials 24:2339\u20132349","journal-title":"Biomaterials"},{"key":"123_CR7","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1016\/j.eurpolymj.2006.08.009","volume":"42","author":"LJ Kong","year":"2006","unstructured":"Kong LJ, Gao Y, Lu GY, Gong YD, Zhao NM, Zhang XF (2006) A study on the bioactivity of chitosan\/nano-hydroxyapatite composite scaffolds for bone tissue engineering. Eur Polym J 42:3171\u20133179","journal-title":"Eur Polym J"},{"key":"123_CR8","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1016\/j.eurpolymj.2007.06.016","volume":"43","author":"GY Lu","year":"2007","unstructured":"Lu GY, Kong LJ, Sheng BY, Wang G, Gong YD, Zhang XF (2007) Degradation of covalently cross-linked carboxymethyl chitosan and its potential application for peripheral nerve regeneration. Eur Polym J 43:3807\u20133818","journal-title":"Eur Polym J"},{"key":"123_CR9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0142-9612(01)00094-1","volume":"23","author":"F Mi","year":"2002","unstructured":"Mi F, Tan Y, Liang H, Sung H (2002) In vivo biocompatibility and degradability of a novel injectable chitosan based implant. Biomaterials 23:181\u2013191","journal-title":"Biomaterials"},{"key":"123_CR10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0144-8617(97)00113-6","volume":"34","author":"J Ragnhild","year":"1997","unstructured":"Ragnhild J, Hjerde N, Varum KM (1997) Chemical composition of O-(carboxymethyl) chitins in relation to lysozyme degradation rate. Carbohydr Polym 34:131\u2013139","journal-title":"Carbohydr Polym"},{"key":"123_CR11","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0142-9612(96)00167-6","volume":"18","author":"K Tomihata","year":"1997","unstructured":"Tomihata K, Ikada Y (1997) In vitro and in vivo degradation of films of chitin and its deacetylated derivatives. Biomaterials 18:567\u2013575","journal-title":"Biomaterials"},{"key":"123_CR12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/jbm.1270","volume":"59","author":"PJV Vord","year":"2002","unstructured":"Vord PJV, Matthew HWT, DeSilva SP, Mayton L, Wu B, Wooley PH (2002) Evaluation of the biocompatibility of a chitosan scaffold in mice. J Biomed Mater Res 59:585\u2013590","journal-title":"J Biomed Mater Res"},{"key":"123_CR13","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1016\/S0142-9612(03)00109-1","volume":"24","author":"X Xu","year":"2003","unstructured":"Xu X, Yee WC, Hwang PY, Yu H, Wan AC, Gao S, Boon KL, Mao HQ, Leong KW, Wang S (2003) Peripheral nerve regeneration with sustained release of poly(phosphoester) microencapsulated nerve growth factor within nerve guide tubes. Biomaterials 24:2405\u20132412","journal-title":"Biomaterials"},{"key":"123_CR14","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1021\/bm050328q","volume":"6","author":"A Zhu","year":"2005","unstructured":"Zhu A, Fang N (2005) Adhesion dynamics, morphology, and organization of 3T3 fibroblast on chitosan and its derivative: the effect of O-carboxymethylation. Biomacromolecules 6:2607\u20132614","journal-title":"Biomacromolecules"}],"container-title":["Biotechnology Letters"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-009-0123-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10529-009-0123-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10529-009-0123-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T16:03:10Z","timestamp":1559145790000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10529-009-0123-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,17]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["123"],"URL":"https:\/\/doi.org\/10.1007\/s10529-009-0123-1","relation":{},"ISSN":["0141-5492","1573-6776"],"issn-type":[{"value":"0141-5492","type":"print"},{"value":"1573-6776","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,17]]}}}